Macrophage polarization: an important role in inflammatory diseases
Front Immunol. 2024 Apr 10;15:1352946. doi: 10.3389/fimmu.2024.1352946. eCollection 2024.ABSTRACTMacrophages are crucial cells in the human body's innate immunity and are engaged in a variety of non-inflammatory reactions. Macrophages can develop into two kinds when stimulated by distinct internal environments: pro-inflammatory M1-like macrophages and anti-inflammatory M2-type macrophages. During inflammation, the two kinds of macrophages are activated alternatively, and maintaining a reasonably steady ratio is critical for maintaining homeostasis in vivo. M1 macrophages can induce inflammation, but M2 macrophages suppress...
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Min Luo Fukun Zhao Huan Cheng Mu Su Yuanmin Wang Source Type: research
Case report: Shingles-associated probable Bickerstaff brainstem encephalitis with IgM anti-sulfatide positivity
CONCLUSIONS: We emphasize the importance of a careful medical history and assessment of clinical symptoms, performing MRI, testing autoimmune antibodies for rapid diagnosis, and ruling out differential diagnoses. Further studies involving more patients with BBE with IgM anti-sulfatide autoantibodies will increase the understanding of the clinical characteristics and advance the diagnosis and treatment of this syndrome. Meanwhile, it is crucial for dermatologists to know about this severe neurological complication following shingles.PMID:38660303 | PMC:PMC11041370 | DOI:10.3389/fimmu.2024.1358886 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Xiaoxue Fu Qianli Zhan Linjie Zhang Xiaoyan Tian Source Type: research
Hepatic micro ‐abscesses as an unusual initial presentation of systemic lupus erythematosus: A case report
We report the case of a 27-year-old female who presented with persistent high-grade fever, bilateral exudative lymphocytic pleural effusion, hepatic micro-abscesses, anemia, and lymphopenia. Despite extensive investigations and antibiotic therapy, the patient's condition continued to worsen. The diagnosis of hepatic vasculitis, a rare manifestation of SLE, was ultimately made based on clinical suspicion, positive autoimmune markers, and negative septic workup. The patient responded well to high-dose corticosteroid therapy and intravenous immunoglobulin, with resolution of liver lesions and clinical improvement. Hepatic inv...
Source: Clinical Case Reports - April 25, 2024 Category: General Medicine Authors: Sreethish Sasi,
Mugahid Eltahir,
Ezzeddin Ibrahim,
Aishwariya Padmakumari,
Jouhar Kolleri,
Tasneem Abdallah,
Ahmed Labib Shehatta,
Nawal Hadwan,
Hani Jaouni,
Muna Al ‐Maslamani Tags: CASE REPORT Source Type: research
Successful treatment of concurrent cold agglutinin disease and myelodysplastic syndrome
Herein, we describe a case of severe anemia presenting with myelodysplastic syndrome with cold agglutinin disease that was successfully treated by a moderate dose of steroids followed by cyclosporine. In patients with myelodysplastic syndrome, autoimmunity in erythroid cells is occasionally demonstrated, and autoimmune hemolytic anemia is seen in some patients. However, hemolytic anemia with cold agglutinin in patients with myelodysplastic syndrome is less common, and the effect of corticosteroids for autoimmune hemolytic anemia caused by cold agglutinin is thought to be limited. (Source: Transfusion and Apheresis Science)
Source: Transfusion and Apheresis Science - April 25, 2024 Category: Hematology Authors: Rie Tabata, Chiharu Tabata Source Type: research
Guillain –Barre syndrome following scrub typhus: a case report and literature review
Scrub typhus is an acute infectious disease caused by Orientia tsutsugamushi. Guillain –Barre syndrome (GBS) is an autoimmune-mediated peripheral neuropathy with a frequent history of prodromal infections, but ... (Source: BMC Neurology)
Source: BMC Neurology - April 25, 2024 Category: Neurology Authors: Shijun Hu, Zhichuan lin, Tao Liu, Shixiong Huang and Hui Liang Tags: Case Report Source Type: research
Acute myocardial infarction due to spontaneous coronary artery dissection in a young male with systemic lupus erythematosus: A case report
Exp Ther Med. 2024 Apr 9;27(6):246. doi: 10.3892/etm.2024.12534. eCollection 2024 Jun.ABSTRACTSystemic lupus erythematosus (SLE) is an autoimmune disease which typically presents in young women. Patients with SLE exhibit features of accelerated atherosclerosis. Here, the present study reported a rare case of acute myocardial infarction (AMI) in a male patient diagnosed with SLE. A 29-year-old male with no cardiovascular history was diagnosed with AMI and underwent coronary angiography, which showed a long-extended spiral-shaped dissection of the right coronary artery (RCA). The patient's autoimmune panel tested positive fo...
Source: Experimental and Therapeutic Medicine - April 24, 2024 Category: General Medicine Authors: Yunyi Li Quan Zhou Xiao Meng Source Type: research
Acute myocardial infarction due to spontaneous coronary artery dissection in a young male with systemic lupus erythematosus: A case report
Exp Ther Med. 2024 Apr 9;27(6):246. doi: 10.3892/etm.2024.12534. eCollection 2024 Jun.ABSTRACTSystemic lupus erythematosus (SLE) is an autoimmune disease which typically presents in young women. Patients with SLE exhibit features of accelerated atherosclerosis. Here, the present study reported a rare case of acute myocardial infarction (AMI) in a male patient diagnosed with SLE. A 29-year-old male with no cardiovascular history was diagnosed with AMI and underwent coronary angiography, which showed a long-extended spiral-shaped dissection of the right coronary artery (RCA). The patient's autoimmune panel tested positive fo...
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Yunyi Li Quan Zhou Xiao Meng Source Type: research
Acute myocardial infarction due to spontaneous coronary artery dissection in a young male with systemic lupus erythematosus: A case report
Exp Ther Med. 2024 Apr 9;27(6):246. doi: 10.3892/etm.2024.12534. eCollection 2024 Jun.ABSTRACTSystemic lupus erythematosus (SLE) is an autoimmune disease which typically presents in young women. Patients with SLE exhibit features of accelerated atherosclerosis. Here, the present study reported a rare case of acute myocardial infarction (AMI) in a male patient diagnosed with SLE. A 29-year-old male with no cardiovascular history was diagnosed with AMI and underwent coronary angiography, which showed a long-extended spiral-shaped dissection of the right coronary artery (RCA). The patient's autoimmune panel tested positive fo...
Source: Experimental and Therapeutic Medicine - April 24, 2024 Category: General Medicine Authors: Yunyi Li Quan Zhou Xiao Meng Source Type: research
A new vision of the efficacy of both CAR-NK and CAR-T cells in treating cancers and autoimmune diseases
AbstractChimeric Antigen Receptor (CAR) based therapies are becoming increasingly important in treating patients. CAR-T cells have been shown to be highly effective in the treatment of hematological malignancies. However, harmful therapeutic barriers have been identified, such as the potential for graft-versus-host disease (GVHD), neurotoxicity, and cytokine release syndrome (CRS). As a result, CAR NK-cell therapy is expected to be a new therapeutic option. NK cells act as cytotoxic lymphocytes, supporting the innate immune response against autoimmune diseases and cancer cells by precisely detecting and eliminating maligna...
Source: Medical Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
The Economic Iceberg of Celiac Disease: More than the Cost of Gluten-Free Food
Celiac disease (CeD) is a chronic autoimmune disorder of global relevance, with the potential for acute and long-term complications. However, the economic burden of CeD is rarely considered and largely thought of as limited to the cost of gluten-free food. Fortunately, recent research has shed light on the various societal costs of CeD across the healthcare continuum.In this article, we summarize the current evidence on the economic impacts of CeD which suggest that the societal economic burden of CeD stretches beyond the cost of gluten-free food. (Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Soran R. Bozorg, Anne Lee, Karl M årild, Joseph Murray Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research
Contributions of Synthetic Chemicals to Autoimmune Disease Development and Occurrence
AbstractPurpose of ReviewExposure to many synthetic chemicals has been linked to a variety of adverse human health effects, including autoimmune diseases. In this scoping review, we summarize recent evidence detailing the effects of synthetic environmental chemicals on autoimmune diseases and highlight current research gaps and recommendations for future studies.Recent FindingsWe identified 68 recent publications related to environmental chemical exposures and autoimmune diseases. Most studies evaluated exposure to persistent environmental chemicals and autoimmune conditions including rheumatoid arthritis (RA), systemic lu...
Source: Current Environmental Health Reports - April 24, 2024 Category: Environmental Health Source Type: research
Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: a role for netting neutrophils with resident memory T cells in situ
AbstractNeuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the CNS characterized by the production of disease-specific autoantibodies against aquaporin-4 (AQP4) water channels. Animal model studies suggest that anti-AQP4 antibodies cause a loss of AQP4-expressing astrocytes, primarily via complement-dependent cytotoxicity. Nonetheless, several aspects of the disease remain unclear, including: how anti-AQP4 antibodies cross the blood –brain barrier from the periphery to the CNS; how NMOSD expands into longitudinally extensive transverse myelitis or optic neuritis; how multiphasic courses occur; and...
Source: Acta Neuropathologica - April 24, 2024 Category: Neurology Source Type: research
Serum vitamins and homocysteine levels in autoimmune liver disease: A systematic review and meta ‐analysis
ConclusionMost vitamins are deficient in AILD, so appropriate vitamin supplementation should be necessary. Further studies with larger sample sizes are needed to validate these findings. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 23, 2024 Category: Allergy & Immunology Authors: Jiahuan Li,
Shan Tian,
Bai Ci,
Yuwen Xi,
Xiaoling Deng Tags: REVIEW ARTICLE Source Type: research
NK-like CD8 T Cell: One Potential Evolutionary Continuum between Adaptive Memory and Innate Immunity
Clin Exp Immunol. 2024 Apr 23:uxae038. doi: 10.1093/cei/uxae038. Online ahead of print.ABSTRACTCD8 T cells are crucial adaptive immune cells with cytotoxicity to fight against pathogens or abnormal self-cells via major histocompatibility complex class I-dependent priming pathways. The composition of the memory CD8 T cell pool is influenced by various factors. Physiological aging, chronic viral infection, and autoimmune diseases promote the accumulation of CD8 T cells with highly differentiated memory phenotypes. Accumulating studies have shown that some of these memory CD8 T cells also exhibit innate-like cytotoxicity and ...
Source: Clinical and Developmental Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Qiulei Wang Shaodan Chen Zhenhong Guo Sheng Xia Minghui Zhang Source Type: research
IL-22, a vital cytokine in autoimmune diseases
Clin Exp Immunol. 2024 Apr 23:uxae035. doi: 10.1093/cei/uxae035. Online ahead of print.ABSTRACTInterleukin-22 (IL-22) is a vital cytokine that is dysregulated in various autoimmune conditions including rheumatoid arthritis (RA), multiple sclerosis (MS), and Alzheimer's disease (AD). As the starting point for the activation of numerous signaling pathways, IL-22 plays an important role in the initiation and development of autoimmune diseases. Specifically, imbalances in IL-22 signaling can interfere with other signaling pathways, causing cross regulation of target genes which ultimately leads to the development of immune dis...
Source: Clinical and Developmental Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Jiajin Li Zhen Wu Yuxin Wu Xin Yu Hu Jun Yang Dacheng Zhu Mingyue Wu Xin Li Lutterodt Bentum-Ennin Wanglai Hu Source Type: research
