Xist-ing Data: Why Might Autoimmune Diseases Be More Common in Women?
The purpose of the OADR-ORWH Science Talks series is to examine the state of the science in specific areas impacting research on autoimmune disease and women ’ s health. This session of Science Talks is focused on Xist research and will bring together experts in the field to generate discussion and identify opportunities to advance Xist research as it pertains to autoimmune diseases.For more information go tohttps://orwh.od.nih.gov/about/newsroom/events/oadr-orwh-science-talksAir date: 4/23/2024 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - April 1, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
60th Meeting of the Advisory Committee on Research on Women's Health
Biannual meeting of the Advisory Committee on Research on Women ’ s Health (ACRWH). The NIH Revitalization Act of 1993 established the ACRWH, a Federal Advisory Act (FACA) committee, to give advice and make recommendations on priority issues affecting women ’ s health and sex differences research. ACRWH members are selected from physicians, practitioners, scientists, and other health professionals with balanced representation from across the US. The topic of the meeting is the Middle-Life Health of Women and Menopause. The meeting will include an ORWH Director's Report, panel discussion on the middle life health of wom...
Source: Videocast - All Events - March 7, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Evolution of pathogenic autoantibodies and B cell clones
Autoimmune disease presents a major clinical challenge due to limited treatment options and difficulties predicting adverse events like nephritis and lymphoma. Serum autoantibodies are unreliable prognosticators because they are often detected in patients with mild and severe disease alike. My research combines analysis of clinical samples and mouse models to understand how pathogenic autoantibodies develop and identify therapeutic targets specific to autoreactive B cells. We have developed a multi-omics single cell approach to longitudinally track autoreactive B cell clones harbouring lymphoma mutations in patients with S...
Source: Videocast - All Events - March 6, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
8th Annual Vivian W. Pinn Symposium
The Vivian W. Pinn Symposium honors the first full-time director of National Institutes of Health (NIH) Office of Research on Women's Health (ORWH), Dr. Vivian Pinn, and is held every year during National Women ’ s Health Week. This event serves as a critical forum for experts across sectors to communicate and collaborate for the advancement of women ’ s health. The title of this year ’ s symposium is “ Synergy in Science: Innovations in Autoimmune Disease Research and Care. "For more information go tohttps://orwh.od.nih.gov/about/newsroom/events/8th-annual-vivian-w-pinn-symposium hereAir date: 5/15/2024 1:00:0...
Source: Videocast - All Events - February 27, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG seminar - Neutrophils: acute responders in chronic inflammatory diseases
Dr. Kaplan's research has focused on identifying mechanisms of immune dysregulation, organ damage, and premature vascular disease in systemic autoimmunity. More specifically, she investigates how innate immunity (in particular, type I interferons and myeloid cells) promote autoimmune responses and end-organ damage in systemic lupus erythematosus, rheumatoid arthritis, and other systemic autoimmune diseases. Recently, her research has focused on identifying abnormalities of neutrophil subsets, aberrant myeloid immunometabolism and the role of neutrophil extracellular traps (NETs) in systemic autoimmune disorders and chronic...
Source: Videocast - All Events - December 12, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
The dark side of DNA - how the immune system senses DNA as a danger signal
Zhijian “ James ” Chen ’ s research into complex cellular biochemistry has led to the discovery of pathways and proteins that trigger immune and stress responses. Chen has identified proteins, such as the mitochondrial protein MAVS, that are crucial to the body ’ s defense against RNA viruses such as influenza and Ebola. Now, Chen and his team are dissecting a signaling pathway involving a novel DNA sensor – cyclic GMP-AMP (cGAMP) synthase, or cGAS – which activates an interferon response that may play a role in immune defense against pathogens and malignant cells, as well as in autoimmune diseases such as lupu...
Source: Videocast - All Events - July 26, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - MHC-II heterozygosity limits T1D susceptibility through non-cognate negative selection.
The ability of T cells to distinguish highly similar peptide ligands bound to a specific class of MHC proteins is the underlying basis for a functioning adaptive immune system. Why TCRs - which are structurally very similar to antibodies - only bind MHC proteins is poorly understood. The Huseby lab is focused on the molecular and cellular pathways that govern the generation, maintenance and function of a self-tolerant T cell repertoire and the autoimmune consequences of self-tolerance failure. To understand how T cell repertoires develop and how defects in the process lead to autoimmune disease, Dr. Huseby ’ s group has ...
Source: Videocast - All Events - May 11, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Cornelia Bergmann
The Bergmann lab researches innate and adaptive immune responses to viral infection of the central nervous system (CNS), with an emphasis on mechanisms contributing to viral persistence and demyelinating disease, similar to multiple sclerosis in human. Control of viral encephalomyelitis or latent/persisting viruses in the central nervous system (CNS) poses a challenge to provide protection while minimizing immune-mediated damage to neurons and glia. Dr. Bergmann ’ s research interests reside in two broad areas of neuroinflammation and central nervous system (CNS) pathology: one investigates innate and adaptive immune res...
Source: Videocast - All Events - February 15, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH – FDA COVID SIG Lecture with Helen Su, M.D., Ph.D.
Helen Su, M.D., Ph.D., is chief of the Human Immunological Diseases Section in NIAID. The Human Immunological Diseases Section (HIDS) carries out research to understand the molecular mechanisms regulating the human immune system and how their derangements cause disease. They study patients with poorly characterized, inherited immunodeficiencies and autoimmune diseases, often lacking molecular diagnoses.
Major Areas of Research: Defining the molecular mechanisms of new inherited human immunological diseases; Understanding DOCK8 function in health and human disease; Elucidating innate immunoregulatory mechanisms for contro...
Source: Videocast - All Events - February 10, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH/FDA IIG Seminar - Cornelia Bergmann
The Bergmann lab researches innate and adaptive immune responses to viral infection of the central nervous system (CNS), with an emphasis on mechanisms contributing to viral persistence and demyelinating disease, similar to multiple sclerosis in human. Control of viral encephalomyelitis or latent/persisting viruses in the central nervous system (CNS) poses a challenge to provide protection while minimizing immune-mediated damage to neurons and glia. Dr. Bergmann ’ s research interests reside in two broad areas of neuroinflammation and central nervous system (CNS) pathology: one investigates innate and adaptive immune res...
Source: Videocast - All Events - February 6, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Immunology Interest Group: Balancing tolerance and immunity downstream of the antigen receptor
This reporter serves as an in vivo sensor of both self and foreign antigen encounter, and serves to unmask enormous clonal heterogeneity among superficially uniform populations of B cells. Recent work has focused on dissecting the distinct roles of the IgM and IgD B cell receptor isotypes in regulating the immune responses of self-reactive B cells.For more information go tohttps://www.niaid.nih.gov/research/immunology-seminarsAir date: 12/7/2022 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 28, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Julie Zikherman - Balancing tolerance and immunity downstream of the antigen receptor
This reporter serves as an in vivo sensor of both self and foreign antigen encounter, and serves to unmask enormous clonal heterogeneity among superficially uniform populations of B cells. Recent work has focused on dissecting the distinct roles of the IgM and IgD B cell receptor isotypes in regulating the immune responses of self-reactive B cells.For more information go tohttps://www.niaid.nih.gov/research/immunology-seminarsAir date: 12/7/2022 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 22, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
NIDCR Clinical Research Fellowship Grand Rounds
Dear Colleagues,
Please join us for the NIDCR Clinical Research Fellowship Grand Rounds.
Lecture Title: " Complications and Diagnosis of Sj ö gren ’ s Syndrome and Clinical Trials for Treatment "
Presenter: Athena Papas, DMD, PhD, FACD
Date: Friday, November 4, 2022
Time: 10:00am -11:00am
Location: Lipsett Amphitheater – Videocast
Overview:
Sj ö gren ’ s Syndrome is an autoimmune disease that causes salivary gland dysfunction and subsequent severe dry mouth, which can lead to a significant reduction in quality of life. Dr. Papas will discuss her research that considers the cognitive issues and oral complications...
Source: Videocast - All Events - October 28, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
NIMHD Director's Seminar Series - Dr. Judith A. James
As Vice President of Clinical Affairs and Chair of Arthritis and Clinical Immunology, Judith A. James, M.D., Ph.D., leads the largest research program at the Oklahoma Medical Research Foundation (OMRF). Dr. James and her research group focus on understanding the causes and mechanisms of autoimmune disease onset, the evolution of autoantibodies, and the interplay of genes and environment in systemic autoimmunity.
Her talk is entitled, “ Improve Rheumatic Disease/Decrease Disability in American Indians. ”Air date: 11/3/2022 2:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 14, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Demystifying Medicine: Epigenetic Contribution to Autoimmune Diseases / Anticytokine Autoantibodies: Important Underappreciated Cofactors in Rare and Common Conditions
Jointly sponsored by FAES and NIH, the Demystifying Medicine course aims to bridge exciting developments in medicine with advances in the basic biological and engineering sciences. When possible, a live patient introduces the course topic by discussing their disease, followed by a physician scientist who describes clinical aspects of the disease including therapy and challenges, followed by bench scientist who describes what we know and don't know regarding mechanism. The course is designed to excite as well as inform medical and Ph.D. students, fellows, basic and physician scientists, and program planners.For more informa...
Source: Videocast - All Events - December 21, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
