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S100A9 is not essential for disease expression in an acute (K/BxN) or chronic (CIA) model of inflammatory arthritis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: S100A8 and S100A9 are not essential for disease expression in either the K/BxN serum transfer or the CIA model of inflammatory arthritis. PMID: 19922019 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - November 21, 2009 Category: Rheumatology Authors: Rampersad R, Esserman D, McGinnis M, Lee D, Patel D, Tarrant T Tags: Scand J Rheumatol Source Type: journals

Spectrum of Magnetic Resonance Imaging Appearances of Juvenile Temporomandibular Joints (TMJ) in Non-Rheumatic Children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The vast majority of juvenile TMJ in non-rheumatic children shows no MRI abnormalities. Exceptions, including a discrete enhancement of the synovial membrane (3%) or small joint effusions (3%), can occur in a minority of patients, but none of them are accompanied by other signs of inflammation or morphological changes of the TMJ. PMID: 19922317 [PubMed - as supplied by publisher] (Source: Acta Radiologica)
Source: Acta Radiologica - November 21, 2009 Category: Radiology Authors: Tzaribachev N, Fritz J, Horger M Tags: Acta Radiol Source Type: journals

Eli Sercarz dies at 75; UCLA scientist made key discoveries in immunologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sercarz studied the concepts behind autoimmune diseases. Eli E. Sercarz, who explored the mechanisms of autoimmunity and developed key concepts about how the body's immune system attacks its own tissues, died of renal cell cancer Nov. 3 in Topanga. He was 75. (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - November 21, 2009 Category: Science Source Type: news

Rituximab-induced nonspecific interstitial pneumonia like reaction in a patient with idiopathic thrombocytopenic purpuraEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the second case to develop this complication for a non-malignant disorder. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - November 20, 2009 Category: Respiratory Medicine Authors: Charalambos Protopapadakis, Katerina M. Antoniou, Argiro Voloudaki, Katerina Samara, Athanasia Proklou, Giorgos Margaritopoulos, Nikolaos M. Siafakas Source Type: journals

Auditory function in women with autoimmune inner ear diseases and their offspringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These preliminary findings suggest that the prevalence of congenital ASNHL may be increased in offspring born to women with AIED. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - November 20, 2009 Category: ENT & OMF Authors: Chang-qiang Tan, Wei-da Dong, Lang Guo, He Huang, Deng-yuan Wang Tags: Research papers Source Type: journals

Environmentally-acquired bacteria influence microbial diversity and natural innate immune responses at gut surfacesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Early-life environment significantly affects both microbial composition of the adult gut and mucosal innate immune function. We observed that a microbiota dominated by lactobacilli may function to maintain mucosal immune homeostasis and limit pathogen colonization. (Source: BMC Biology - Latest articles)
Source: BMC Biology - Latest articles - November 20, 2009 Category: Biology Authors: Imke MulderBettina SchmidtChristopher StokesMarie LewisMick BaileyRustam AminovJames ProsserBhupinder GillJohn PluskeClaus-Dieter MayerCorran MuskDenise Kelly Source Type: journals

VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hairy cell leukemia variant (HCLv) presents with high disease burden, lack of typical antigens like CD25, and poor response to standard treatments like cladribine. Occasionally, patients with classic HCL respond poorly. Clinical and molecular features of HCL and HCLv has not been compared. Rearrangements expressing immunoglobulin VH chain were sequenced, including 22 from 20 patients with HCLv and 63 from 62 patients with classic HCL. Most patients were seeking relapsed/refractory trials, representing a poor-prognosis population. VH4-34, a gene commonly used in autoimmune disorders, was observed in 8 (40%) HCLv and 6 (10%)...
Source: Blood - November 19, 2009 Category: Hematology Authors: Arons, E., Suntum, T., Stetler-Stevenson, M., Kreitman, R. J. Tags: Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: journals

HMGB1, an innate alarmin, in the pathogenesis of type 1 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HMGB1, an evolutionarily conserved chromosomal protein, was recently re-discovered to act as a "danger signal" (alarmin) to alert the innate immune system for the initiation of host defense or tissue repair. Extracellular HMGB1 can be either passively released from damaged/necrotic cells or secreted by activated immune cells. Upon stimulation, dendritic cells (DCs), macrophages and natural killer (NK) cells secrete high levels of HMGB1 into the intercellular milieu. HMGB1 is potent to target DCs, macrophages, neutrophils and CD4(+) T cells. It also upregulates the expression of BCL-XL by which it may prevent the elimin...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Zhang S, Zhong J, Yang P, Gong F, Wang CY Tags: Int J Clin Exp Pathol Source Type: journals

Disparate distribution of activating and inhibitory killer cell immunoglobulin-like receptor genes in patients with systemic lupus erythematosus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The genes of killer cell immunoglobulin-like receptors (KIRs), which are involved in the activation of T cells and natural killer cells, are highly variable. In recent years, the role of KIRs in autoimmune diseases has received increasing attention. The present study was undertaken to determine the association of the polymorphism of KIR genes with the susceptibility to systemic lupus erythematosus (SLE). The polymorphism of KIR genes of 93 patients with SLE together with 123 healthy donors as the control group was determined by polymerase chain reaction with sequence-specific primers. Twenty-seven novel gene ...
Source: Lupus - November 19, 2009 Category: Rheumatology Authors: Hou YF, Zhang YC, Jiao YL, Wang LC, Li JF, Pan ZL, Yang QR, Sun HS, Zhao YR Tags: Lupus Source Type: journals

Recent advances in autoimmune pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Autoimmune pancreatitis (AIP) is distinct from calcifying and obstructive forms of chronic pancreatitis. Clinically and histologically it has two distinct subsets: (i) lymphoplasmacytic sclerosing pancreatitis or type 1 AIP which appears to be a systemic disease characterised by abundant infiltration of affected organs with immunoglobulin G4 (IgG4)-positive plasma cells and (2) duct-centric or type 2 AIP characterised by granulocyte epithelial lesions in the pancreas without systemic involvement. In AIP a marked lymphoplasmacytic infiltrate that responds dramatically to steroid therapy suggests an autoimmune aetiology. How...
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Park, D H, Kim, M-H, Chari, S T Tags: GUT Recent advances in basic science, Pancreas and biliary tract, Pancreatitis Source Type: journals

Identification of GP2, the major zymogen granule membrane glycoprotein, as the autoantigen of pancreatic antibodies in Crohn's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Anti-GP2 autoantibodies constitute novel Crohn’s disease-specific markers, the quantification of which could significantly improve the serological diagnosis of IBD. The expression of GP2 in human enterocytes suggests an important role for anti-GP2 response in the pathogenesis of Crohn’s disease. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Roggenbuck, D, Hausdorf, G, Martinez-Gamboa, L, Reinhold, D, Buttner, T, Jungblut, P R, Porstmann, T, Laass, M W, Henker, J, Buning, C, Feist, E, Conrad, K Tags: Ulcerative colitis, Pancreas and biliary tract Inflammatory bowel disease Source Type: journals

The Evaluation of Lower-Extremity UlcersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Semin intervent Radiol 2009; 26: 286-295DOI: 10.1055/s-0029-1242204ABSTRACTLower-limb ulceration is prevalent in Western countries. There are many different types of ulcers with several causes. The most prevalent are those due to vascular disease, of which venous is the most common, accounting for over two-thirds of all types of ulcers. There are also many other causes for ulceration such as malignancy, infections, and skin, drug-induced, and autoimmune diseases. The ulcers have different characteristics, which may be differentiated by the history and clinical examination of the patients. However, objective documentation f...
Source: Seminars in Interventional Radiology - November 18, 2009 Category: Radiology Source Type: journals

Extracorporeal photo-apheresis for the treatment of steroid-resistant graft versus host diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Acute and chronic graft versus host disease are frequent and potentially severe complications of allogeneic hematopoietic stem cell transplantation and are among the leading causes of non-relapse transplant-related mortality. For patients with steroid refractory disease, prognosis is particularly poor and although a variety of treatment options are available, responses are commonly transient and the side effects often intolerable. Since it was first introduced for the treatment of cutaneous T-cell lymphoma, extracorporeal photo-apheresis has been utilized as an immunomodulatory therapy for certain autoimmune dise...
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Kristin Baird, Alan S. Wayne Tags: Guest Editor: Stephen J. Wagner Source Type: journals

Pre-eclampsia linked to thyroidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This well-conducted research used two separate studies to examine whether pre-eclampsia during pregnancy affects thyroid function. Although both studies found a clear link between pre-eclampsia and blood tests that indicated an underactive thyroid, many questions remain unanswered. Principally, it is unclear whether blood test results that indicated an underactive thyroid were associated with any signs or symptoms of disease. While women had altered levels of one of the thyroid hormones tested, few women were found to have abnormal levels of both. Abnormal levels of just one hormone does not necessarily sugge...
Source: NHS News Feed - November 18, 2009 Category: Consumer Health News Tags: Pregnancy/child Source Type: news

Effect of leflunomide on liver regeneration after partial hepatectomy in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The findings imply that oxidative stress products play a preventive role in liver regeneration after PH and leflunomide ameliorates the regeneration probably by the radical scavenging and antioxidant activities. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00383-009-2529-1Authors Abdurrahman Karaman, Inonu University Department of Pediatric Surgery, Faculty of Medicine, Turgut Ozal Medical Center Malatya TurkeyHale Kirimlioglu, Inonu University Department of Pathology, Faculty of Medicine, Turgut Ozal Medical Center Malatya TurkeyErkan Tas, Inonu University Department of...
Source: Pediatric Surgery International - November 18, 2009 Category: Surgery Tags: Pediatric Surgery International Source Type: journals

Pre-eclampsia, soluble fms-like tyrosine kinase 1, and the risk of reduced thyroid function: nested case-control and population based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Increased serum concentration of soluble fms-like tyrosine kinase 1 during pre-eclampsia is associated with subclinical hypothyroidism during pregnancy. Pre-eclampsia may also predispose to reduced thyroid function in later years. (Source: BMJ Online First)
Source: BMJ Online First - November 18, 2009 Category: Journals (General) Authors: Levine, R. J, Vatten, L. J, Horowitz, G. L, Qian, C., Romundstad, P. R, Yu, K. F, Hollenberg, A. N, Hellevik, A. I, Asvold, B. O, Karumanchi, S A. Tags: Clinical trials (epidemiology), Epidemiologic studies, Pregnancy, Reproductive medicine, Thyroid disease RESEARCH Source Type: journals

Cutting Edge: Depletion of Foxp3+ Cells Leads to Induction of Autoimmunity by Specific Ablation of Regulatory T Cells in Genetically Targeted Mice1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have recently described two independent mouse models in which the administration of diphtheria toxin (DT) leads to specific depletion of regulatory T cells (Tregs) due to expression of DT receptor-enhanced GFP under the control of the Foxp3 promoter. Both mouse models develop severe autoimmune disorders when Foxp3(+) Tregs are depleted. Those findings were challenged in a recent study published in this journal suggesting the expression of Foxp3 in epithelial cells as the cause for disease development. By using genetic, cellular, and immunohistochemical approaches, we do not find evidence for Foxp3-expression in nonh...
Source: Journal of Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Kim J, Lahl K, Hori S, Loddenkemper C, Chaudhry A, Deroos P, Rudensky A, Sparwasser T Tags: J Immunol Source Type: journals

Cutting Edge: Normal Regional Lymph Node Enrichment of Antigen-Specific Regulatory T Cells with Autoimmune Disease-Suppressive Capacity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we quantified disease-specific Treg (DS-Treg) as Treg that preferentially suppress one autoimmune disease over another in day 3 thymectomized recipients. A striking difference was found among individual lymph nodes (LN) of normal mice; Treg from draining LN were 15-50 times more efficient than those of nondraining LN at suppressing autoimmune diseases of ovary, prostate, and lacrimal glands. The difference disappeared upon auto-Ag ablation and returned upon auto-Ag re-expression. In contrast, the CD4(+)CD25(-) effector T cells from different individual LN induced multiorgan inflammation with comparable organ...
Source: Journal of Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Wheeler KM, Samy ET, Tung KS Tags: J Immunol Source Type: journals

Mesenchymal Stem Cells Derived from Human Gingiva Are Capable of Immunomodulatory Functions and Ameliorate Inflammation-Related Tissue Destruction in Experimental Colitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we isolated a new population of stem cells from human gingiva, a tissue source easily accessible from the oral cavity, namely, gingiva-derived mesenchymal stem cells (GMSCs), which exhibited clonogenicity, self-renewal, and multipotent differentiation capacities. Most importantly, GMSCs were capable of immunomodulatory functions, specifically suppressed peripheral blood lymphocyte proliferation, induced expression of a wide panel of immunosuppressive factors including IL-10, IDO, inducible NO synthase (iNOS), and cyclooxygenase 2 (COX-2) in response to the inflammatory cytokine, IFN-gamma. Cell-based therapy...
Source: Journal of Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Shi S, Le AD Tags: J Immunol Source Type: journals

Pulsed Intravenous Cyclophosphamide and Methylprednisolone Therapy in Refractory Pemphigus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Pulsed intravenous therapy with cyclophosphamide and methylprednisolone can be an effective treatment for refractory pemphigus but its adverse effects should be considered prior to therapy and closely monitored in patients on treatment. PMID: 19922532 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 18, 2009 Category: Dermatology Authors: Saha M, Powell AM, Bhogal B, Black MM, Groves RW Tags: Br J Dermatol Source Type: journals

Fetal microchimerism: the cellular and immunological legacy of pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Review ArticlesDavid M. Lissauer, Karen P. Piper, Paul A.H. Moss, Mark D. Kilby, Expert Reviews in Molecular Medicine, Volume 11 , pp e33AbstractDuring pregnancy there is transplacental traffic of fetal cells into the maternal circulation. Remarkably, cells of fetal origin can then persist for decades in the mother and are detectable in the circulation and in a wide range of tissues. Maternal CD8 T cell responses directed against fetal antigens can also be detected following pregnancy. However, the impact that the persistence of allogenic cells of fetal origin and the maternal immune response towards them has on the mother...
Source: Expert Reviews in Molecular Medicine - November 17, 2009 Category: Molecular Biology Source Type: journals

Treatment of Chronic Hepatitis C in a Patient Affected by Systemic SclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The currently recommended treatment for patients infected with hepatitis C virus (HCV) is pegilated interferon α (IFN α) plus ribavirin. Despite the numerous benefits of this therapy, there is an increasing concern regarding his tolerance. Among the most common side effects, interferon may trigger the onset or exacerbation of autoimmune diseases. When chronic hepatitis C coexists with an autoimmune disorder, it is not clear whether using interferon is better than avoiding it. We evaluated the disease state of a 55-year old female affected by sistemic sclerosis (SSc), during and after therapy with IFN;...
Source: Gastroenterology Research and Practice - November 17, 2009 Category: Gastroenterology Source Type: journals

Functional activation of proline-rich tyrosine kinase2 (PYK2) in peripheral blood mononuclear cells from patients with systemic lupus erythematosusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings indicate that phosphorylated PYK2 in SLE PBMCs may induce the expression of CD40L and CTLA4, and subsequently the cell proliferation. PYK2 signaling enhances the autoreactive lymphocyte activation and plays an important role in the pathogenesis of SLE. (Source: BioMed Central)
Source: BioMed Central - November 17, 2009 Category: Journals (General) Authors: Meiying WangHongsheng SunWei ZhangYuanchao Zhang Source Type: journals

Functional polymorphism of cytotoxic T-lymphocyte antigen 4 and nasopharyngeal carcinoma susceptibility in a Chinese populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we performed a case[ndash]control study in a Chinese population. Our result showed that the CTLA-4 +49 A>G polymorphism is associated with NPC susceptibility. The subjects carrying the CTLA-4 +49 AA genotype have a [sim]1.8-fold increased risk of NPC (adjust OR 1.83; 95% CI, 1.16[ndash]2.93) when compared with the GG genotype. (Source: International Journal of Immunogenetics)
Source: International Journal of Immunogenetics - November 17, 2009 Category: Genetics & Stem Cells Authors: M. Xiao, F. Qi, X. Chen, Z. Luo, L. Zhang, C. Zheng, S. Hu, X. Jiang, M. Zhou, J. Tang Source Type: journals

Long-term Use and Follow-up of Irradiated Homologous Costal Cartilage Grafts in the Nose [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Based on careful and extensive review of the data, we have concluded that IHCC is well tolerated as a grafting material in rhinoplasty and yields superb functional, structural, and cosmetic results in the most complex and challenging operative cases necessitated by previous unsuccessful nasal surgery, septal perforations, and even in autoimmune diseases that led to nasal deformity. Not only did very few complications occur following the use of 1025 IHCC grafts in 357 patients after 386 rhinoplasties over 24 years (rate, 3.25%), but the rate of complications was no greater than rhinoplasty complication rat...
Source: Archives of Facial Plastic Surgery - November 16, 2009 Category: Cosmetic Surgery Authors: Kridel, R. W. H., Ashoori, F., Liu, E. S., Hart, C. G. Tags: Transplantation, Transplantation, Other, Facial Plastic Surgery, Biomaterials and Implants, Cosmetic Surgery/ Procedures, Nasal Surgery, Rhinoplasty Original Article Source Type: journals

Detection of myelin autoantibodies: evaluation of an assay system for diagnosis of multiple sclerosis in differentiation from other central nervous system diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The ELISA kit we evaluated is suitable for the measurement of neuronal autoantibodies. The initial validation demonstrates its potential use in the differential diagnosis of central neuronal system diseases. Clin Chem Lab Med 2009;47:1395–400. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These results suggest that although IL-23 may have pathogenic activity in a proportion of patients with late-stage RA, it is not abundantly produced in this inflammatory tissue, nor does it have a dominant role in all patient tissues analysed. (Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Hillyer, P., Larche, M. J., Bowman, E. P., McClanahan, T. K., de Waal Malefyt, R., Schewitz, L. P., Giddins, G., Feldmann, M., Kastelein, R. A., Brennan, F. M. Tags: Rheumatoid Arthritis CLINICAL Source Type: journals

Autoimmunity and atherosclerosis: the presence of antinuclear antibodies is associated with decreased carotid elasticity in young women. The Cardiovascular Risk in Young Finns StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Our results indicate that ANA positivity is associated with decreased carotid elasticity in women, suggesting that mechanisms resulting in ANA production may be involved in the development of early atherosclerosis. (Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Pertovaara, M., Kahonen, M., Juonala, M., Laitinen, T., Taittonen, L., Lehtimaki, T., Viikari, J. S. A., Raitakari, O. T., Hurme, M. Tags: Vasculitis, Systemic Lupus Erythematosus and Autoimmunity CLINICAL Source Type: journals

CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. This study provides further evidence that CTLA-4, a susceptibility locus for a number of common autoimmune diseases, may also be involved in the development of ANCA-associated SVV. (Source: Rheumatology)
Source: Rheumatology - November 16, 2009 Category: Rheumatology Authors: Kamesh, L., Heward, J. M., Williams, J. M., Gough, S. C. L., Chavele, K.-M., Salama, A., Pusey, C., Savage, C. O. S., Harper, L. Tags: Vasculitis BASIC SCIENCE Source Type: journals

The PANDAS subgroup of tic disorders and childhood-onset obsessive–compulsive disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Diagnosis and treatment of the PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) variant of Gilles de la Tourette syndrome (GTS) and childhood-onset obsessive–compulsive disorder (OCD) are still controversial issues. Most cross-sectional studies confirm a significant association between GTS and the development of an immune response against group A β-hemolytic streptococcus (GABHS). Moreover, longitudinal retrospective studies suggest that a recent exposure to GABHS might be a risk factor for the onset of tics and obsessive–compulsive symptoms. However, further ...
Source: Journal of Psychosomatic Research - November 16, 2009 Category: Psychiatry & Psychology Authors: Davide Martino, Giovanni Defazio, Gavin Giovannoni Tags: Original Articles Source Type: journals

Lack of Association Between TRAF1/C5 Gene Polymorphisms and Biopsy-proven Giant Cell Arteritis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our results showed no influence of rs10818488 and rs2900180 TRAF1/C5 gene polymorphisms in susceptibility to and clinical expression of GCA. PMID: 19918040 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 16, 2009 Category: Rheumatology Authors: Torres O, Palomino-Morales R, Vazquez-Rodriguez TR, Castañeda S, Morado IC, Miranda-Filloy JA, Ortego-Centeno N, Gonzalez-Alvaro I, Fernandez-Gutierrez B, Martin J, Gonzalez-Gay MA Tags: J Rheumatol Source Type: journals

Association of Interleukin 23 Receptor Polymorphisms with Anti-Topoisomerase-I Positivity and Pulmonary Hypertension in Systemic Sclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Polymorphisms in IL23R are associated with susceptibility to ATA-positive SSc and protective against development of PHT in patients with SSc. PMID: 19918037 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 16, 2009 Category: Rheumatology Authors: Agarwal SK, Gourh P, Shete S, Paz G, Divecha D, Reveille JD, Assassi S, Tan FK, Mayes MD, Arnett FC Tags: J Rheumatol Source Type: journals

Primary immunodeficiency diseases: relevant aspects for pulmonologistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
As imunodeficiências primárias são um grupo de doenças geneticamente heterogêneas que afetam diferentes componentes da imunidade inata e adaptativa, como neutrófilos, macrófagos, células dendríticas, proteínas do sistema complemento, células natural killer e linfócitos B e T. O estudo dessas doenças tem fornecido importantes entendimentos sobre o funcionamento do sistema imune. Mais de 120 diferentes genes já foram identificados, cujas anormalidades são responsáveis aproximadamente 180 diferentes formas de imunodeficiências primárias. Pacientes com imunodeficiências primárias são frequentemente reconhe...
Source: Jornal Brasileiro de Pneumologia - November 14, 2009 Category: Respiratory Medicine Source Type: journals

Gingival Nikolsky's Sign is Useful for Clinical DiagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Article Title and Bibliographic Information: Nikolsky's sign on the gingival mucosa: a clinical tool for oral health practitioners.Mignogna MD, Fortuna G, Leuci S, Ruoppo E, Marasca F, Matarasso S.J Periodontol 2008;79(12):2241-6.Reviewer: Michael D. Martin, DMD, MSD, MPH, MA, PhDPurpose/Question: What is the specificity and sensitivity of the gingival Nikolsky's sign in oral autoimmune mucocutaneous blistering disease?Source of Funding: Information not availableType of Study/Design: Cohort studyLevel of Evidence: Level 2: Limited-quality, patient-oriented evidenceStrength of Recommendation Grade: Not applicable (Source: T...
Source: The Journal of Evidence-Based Dental Practice - November 14, 2009 Category: Dentistry Authors: Michael D. Martin Tags: Diagnosis/Treatment/Prognosis Source Type: journals

Sex Hormones and Immunity to InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Why sex mattersAmong human and nonhuman animals, the prevalence and intensity of infection typically is higher in males than females and may reflect differences in exposure as well as susceptibility to pathogens. Elevated immunity among females is a double-edged sword in which it is beneficial against infectious diseases but is detrimental in terms of increased development of autoimmune ... (Source: Springer Biomedical Sciences titles)
Source: Springer Biomedical Sciences titles - November 14, 2009 Category: Biomedical Science Tags: Immunology Source Type: organizations

Iron deficiency, Helicobacter infection and gastritis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite elegant regulatory mechanisms, iron deficiency anemia (IDA) remains one of the most common nutritional deficiencies of mankind. Iron deficiency is the result of an interplay between increased host requirements, limited external supply, and increased blood loss. When related to increased physiologic needs associated with normal development, iron deficiency is designated physiologic or nutritional. By contrast, pathological iron deficiency, with the exception of gross menorrhagia, is most often the result of gastrointestinal disease associated with abnormal blood loss or malabsorption. If gastroenterologic evalua...
Source: Acta Haematologica - November 13, 2009 Category: Hematology Authors: Hershko C, Ronson A Tags: Acta Haematol Source Type: journals

Stiff-Man-Syndrome: Association of an autoimmune-encephalomyelitis with endocrinopathies and organ-specific antibodiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stiff-Man-Syndrome (SMS) is a complex neuroimmunological disease of the Central Nervous System (CNS) with endocrinological, motoric, vegetative symptoms and is associated with autoantibodies to glutamate decarboxylase (GAD). SMS and its variants, stiff limb syndrome (SLS) and progressive encephalomyelitis with rigidity and myoclonus (PERM), appear to occur more frequently than hitherto thought. The cause of SMS is unknown.In a retrospective assessment of 92 patients (1989–2005) we investigated the correlation between SMS/SLS/PERM, associated autoimmune disorders, organ-specific antibodies and immungenetic HLA-association...
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: N. Keilbar Source Type: journals

Mistletoe therapy as a therapeutic option in a child with lymphomatoid papulosis/CD 30-positive cutaneous lymphoproliferative papulosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion we present a patient with a rare skin disease (LP) with lymph node involvement who is successful treated with mistletoe as a new promising therapeutic option for patients with lymphomatoid papulosis. Further studies should be initiated. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: G. Kameda, K. Michael, A. Längler Source Type: journals

Antigen-Based Therapy for the Treatment of Type 1 DiabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of ABTs for autoimmune disease is still in its infancy, but recent results from clinical studies hold promise that this approach may be able to delay the onset of type 1 diabetes. Diabetes (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - November 13, 2009 Category: Endocrinology Tags: Diabetes & Endocrinology Source Type: info

A case of bullous disease limited to the skin illustrates the spectrum of neoplasia induced autoimmunity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a patient with fatal autoimmune blistering disease with absence of mucous membrane lesions. The pattern of complement indirect immunofluoresence helped identify the prognosis prospectively. This case illustrates yet another presentation of the neoplasia-induced autoimmunity. PMID: 19903433 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - November 13, 2009 Category: Dermatology Authors: Grover RK, Stites PC, Helm TN, Hashimoto T, Beutner EH Tags: Dermatol Online J Source Type: journals

Modulation of experimental autoimmune encephalomyelitis by endogenous Annexin A1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Together these findings suggest that Annexin A1 null mice have an impaired capacity to develop EAE. Furthermore strategies aiming at reducing Annexin A1 functions or expression in T cells might represent a novel therapeutic approach for multiple sclerosis. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - November 13, 2009 Category: Neurology Authors: Nikolaos PaschalidisAsif IqbalFrancesco MaioneElisabeth WoodMauro PerrettiRod FlowerFulvio D'Acquisto Source Type: journals

Chapter 33: Geoepidemiology of Myasthenia Gravis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Myasthenia Gravis (MG) is an autoimmune disease that affects the post synaptic area of the neuromuscular junction. Its hallmark is weakness that worsens with activity. MG incidence is rising in the recent decades, mostly the late onset sub type, which is considered to be due to the aging population or unknown environmental factors. The disease has several subtypes which defer slightly in the clinical characteristics, immunological markers, population distribution and the suitable treatments. The autoimmune nature of the disease is manifested by a decrease in the number of acetylcholine receptors in the muscle receptors...
Source: Autoimmunity Reviews - November 13, 2009 Category: Allergy & Immunology Authors: Meyer A, Levy Y Tags: Autoimmun Rev Source Type: journals

Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In a methotrexate-naive population with early RA and poor prognostic factors, the combination of abatacept and methotrexate provided significantly better clinical and radiographic efficacy compared with methotrexate alone and had a comparable, favourable safety profile. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - November 12, 2009 Category: Rheumatology Authors: Westhovens, R, Robles, M, Ximenes, A C, Nayiager, S, Wollenhaupt, J, Durez, P, Gomez-Reino, J, Grassi, W, Haraoui, B, Shergy, W, Park, S-H, Genant, H, Peterfy, C, Becker, J-C, Covucci, A, Helfrick, R, Bathon, J Tags: Unlocked, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: journals

Prolactin and AutoimmunityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The relationship between prolactin and the immune system has been demonstrated in the last two decades, opening new windows in the field of the immunoendocrinology. Prolactin has an important role in the innate and adaptive immune response. Increased prolactin levels have been described in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, and systemic sclerosis among others. Hyperprolactinemia is associated with active disease and organ involvement in systemic lupus erythematosus. Therefore, prolactin is an integral member of the immunoneuroendocrinol...
Source: Clinical Reviews in Allergy and Immunology - November 12, 2009 Category: Allergy & Immunology Tags: Clinical Reviews in Allergy and Immunology Source Type: journals

Distinguishing clinical and imaging features of nodular regenerative hyperplasia and large regenerative nodules of the liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: NRH and LRN can have distinct clinical presentations and imaging appearances. LRN often result in enhancing liver nodules, whereas NRH usually does not. Clinical and imaging information enables the distinction of LRN and NRH in many cases. (Source: Clinical Radiology)
Source: Clinical Radiology - November 12, 2009 Category: Radiology Authors: J.T. Ames, M.P. Federle, K. Chopra Tags: Original Articles Source Type: journals

Gene expression profiles for the human pancreas and purified islets in Type 1 diabetes: new findings at clinical onset and in long-standing diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Type 1 diabetes (T1D) is caused by the selective destruction of the insulin-producing [beta] cells of the pancreas by an autoimmune response. Due to ethical and practical difficulties, the features of the destructive process are known from a small number of observations, and transcriptomic data are remarkably missing. Here we report whole genome transcript analysis validated by quantitative reverse transcription[ndash]polymerase chain reaction (qRT[ndash]PCR) and correlated with immunohistological observations for four T1D pancreases (collected 5 days, 9 months, 8 and 10 years after diagnosis) and for purified islets from ...
Source: Clinical and Experimental Immunology - November 12, 2009 Category: Allergy & Immunology Authors: R. Planas, J. Carrillo, A. Sanchez, M. C. Ruiz de Villa, F. Nuñez, J. Verdaguer, R. F. L. James, R. Pujol-Borrell, M. Vives-Pi Source Type: journals

Staphylococcus aureus and autoimmune uveitis reactivation in childhood: a possible correlation?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The role of infectious agents in autoimmune diseases has been the subject of several studies and is still under investigation. Here a paediatric case series of autoimmune uveitis is reported. An exacerbation of the ocular inflammation occurred in concomitance with nasal colonisation by Staphylococcus aureus (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - November 12, 2009 Category: Pediatrics Authors: Paolo MoraErilda KamberiFrancesca ManzottiLaura ZavotaJelka Orsoni Source Type: journals

Induction of T cells suppression by dendritic cells transfected with VSIG4 recombinant adenovirus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
VSIG4 has been recently described as a B7 family-related protein. The immunotherapeutic potential of dendritic cells (DCs) transfected with VSIG4 recombinant adenovirus has not been characterized. In the present study, DCs were transfected with human VSIG4 (hVSIG4) recombinant adenovirus, a novel costimulatory molecule known to be a potent inhibitor of T cell activation. Transfected DCs were cocultured with allogeneic T cells and proliferation, cytokine production and T cell activation marker expression were assessed. The results showed that T cell proliferation potential, cytokine production and activation marker expr...
Source: Immunology Letters - November 12, 2009 Category: Allergy & Immunology Authors: Xu S, Sun Z, Wu X, Liu J, He J, Song D, Shan G, Liu H, Yang Z Tags: Immunol Lett Source Type: journals

Mouse Schwann cells activate MHC class I and II restricted T-cell responses, but require external peptide processing for MHC class II presentation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, however, Schwann cells lacked the ability to process exogenous antigen or cross-present endogenous antigen into the MHC class II presentation pathway. Thus, antigen presentation may be a pathological function of Schwann cells exacerbating nerve damage in inflammatory neuropathies. PMID: 19914379 [PubMed - as supplied by publisher] (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - November 12, 2009 Category: Neurology Authors: Zu Hörste GM, Heidenreich H, Mausberg AK, Lehmann HC, Ten Asbroek AL, Saavedra JT, Baas F, Hartung HP, Wiendl H, Kieseier BC Tags: Neurobiol Dis Source Type: journals

Manipulating Antigenic Ligand Strength to Selectively Target Myelin-Reactive CD4+ T Cells in EAEEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The development of antigen-specific therapies for the selective tolerization of autoreactive T cells remains the Holy Grail for the treatment of T-cell-mediated autoimmune diseases such as multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). This quest remains elusive, however, as the numerous antigen-specific strategies targeting myelin-specific T cells over the years have failed to result in clinical success. In this review, we revisit the antigen-based therapies used in the treatment of myelin-specific CD4+ T cells in the context of the functional avidity ...
Source: Journal of NeuroImmune Pharmacology - November 11, 2009 Category: Drugs & Pharmacology Tags: Journal of Neuroimmune Pharmacology Source Type: journals