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4438 records returned

Cytotoxic and antibacterial activities of endophytic fungi isolated from plants at the National Park, Pahang, MalaysiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Results indicate the potential for production of bioactive agents from endophytes of the tropical rainforest flora. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - November 21, 2009 Category: Complementary Medicine Authors: Nurul HazalinKalavathy RamasamyLim MengIbtisam Abdul WahabAnthony ColeAbu Abdul Majeed Source Type: journals

Quantitative Diffusion-Weighted Imaging as an Adjunct to Conventional Breast MRI for Improved Positive Predictive ValueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION. DWI shows potential for improving the PPV of breast MRI for lesions of varied types and sizes. However, considerable overlap in ADC of benign and malignant lesions necessitates validation of these findings in larger studies. (Source: American Journal of Roentgenology)
Source: American Journal of Roentgenology - November 20, 2009 Category: Radiology Authors: Partridge, S. C., DeMartini, W. B., Kurland, B. F., Eby, P. R., White, S. W., Lehman, C. D. Tags: Women's Imaging Source Type: journals

Short-Term Follow-Up of Palpable Breast Lesions With Benign Imaging Features: Evaluation of 375 Lesions in 320 WomenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION. Short-term follow-up is a reasonable alternative to biopsy of palpable breast lesions with benign imaging features, particularly for young women with probable fibroadenoma. (Source: American Journal of Roentgenology)
Source: American Journal of Roentgenology - November 20, 2009 Category: Radiology Authors: Harvey, J. A., Nicholson, B. T., LoRusso, A. P., Cohen, M. A., Bovbjerg, V. E. Tags: Women's Imaging Source Type: journals

Breast Cancer-derived Factors Stimulate Osteoclastogenesis through the Ca2+/Protein Kinase C and Transforming Growth Factor-{beta}/MAPK Signaling Pathways [Mechanisms Of Signal Transduction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breast cancer commonly metastasizes to bone where its growth depends on the action of bone-resorbing osteoclasts. We have previously shown that breast cancer cells secrete factors able to directly stimulate osteoclastogenesis from receptor activator of nuclear factor B ligand (RANKL)-primed precursors and that transforming growth factor-β (TGFβ) plays a permissive role in this process. Now, we evaluate the signaling events triggered in osteoclast precursors by soluble factors produced by MDA-MB-231 human breast carcinoma cells. In mouse bone marrow cultures and RAW 264.7 murine monocytic cells, MDA-MB-231-derived...
Source: Journal of Biological Chemistry - November 20, 2009 Category: Chemistry Authors: Tiedemann, K., Hussein, O., Sadvakassova, G., Guo, Y., Siegel, P. M., Komarova, S. V. Tags: Mechanisms Of Signal Transduction Source Type: journals

In vitro cytotoxic effects of Senecio stabianus Lacaita (Asteraceae) on human cancer cell lines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is aimed to evaluate the in vitro cytotoxicity of Senecio stabianus Lacaita (Asteraceae) against renal adenocarcinoma ACHN, hormone-dependent prostate carcinoma LNCaP, amelanotic melanoma C32 and human breast adenocarcinoma MCF-7 cell lines. The n-hexane extract showed an interesting activity with IC(50) values of 62.7 and 71.1 mug mL(-1) against C32 and LNCaP, respectively. Two compounds identified in the n-hexane extract, linalool and beta-caryophyllene, were found to be active against C32 cells (IC(50) values of 23.2 and 20.1 mug mL(-1), respectively). Among tested constituents, the highest activity was found...
Source: Natural Product Research - November 20, 2009 Category: Biochemistry Authors: Tundis R, Loizzo MR, Bonesi M, Menichini F, Dodaro D, Passalacqua NG, Statti G, Menichini F Tags: Nat Prod Res Source Type: journals

Anaphylaxis to patent blue V: a case series and proposed diagnostic protocolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patent blue V is widely used in the identification of sentinel lymph nodes in patients with breast cancer and other malignancies. Individual case reports of allergy to patent blue V have been described in the medical literature since the 1960s. However, there is little data on clinical features and little experience of which allergy tests are appropriate or useful. We gathered all cases of patent blue V allergy that had been seen and diagnosed in the Department of Allergy, Addenbrooke's Hospital over a 3-year period. We collected clinical details of each case including skin test results. For comparison we recruited 12 heal...
Source: Allergy - November 20, 2009 Category: Allergy & Immunology Authors: R. A. Haque, A. Wagner, J. A. Whisken, S. M. Nasser, P. W. Ewan Source Type: journals

[Expression of Tiam1 in breast carcinomas and its clinical significance.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Tiam1 is closely related to the metastasis of breast carcinoma, and may play an important role in promoting metastasis of breast carcinoma. PMID: 19923095 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 20, 2009 Category: Universities & Medical Training Authors: Wu YQ, Peng G Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals

[Correlation analysis of vascular endothelial growth factor-C expression and clinicopathology in breast cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The high expressions of VEGF-C and C-erbB-2 are closely related to lymph node metastasis in breast cancer patients, and may cooperate in promoting lymph node metastasis of breast carcinoma. Combined detection of VEGF-C, C-erbB-2, p53, ER and PR may help clinical treatment and prognostic evaluation of breast cancer patients. PMID: 19923084 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 20, 2009 Category: Universities & Medical Training Authors: Fu JM, Shi J, Zhou J Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals

[Abnormal expression of beta-catenin and E-cadherin in Her2-positive breast cancer and its implications.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A direct correlation between positive Her2 expression and abnormal beta-catenin expression exists in human breast carcinoma, and positive Her2 expression may have functional interactions with abnormal activation of Wnt/beta-catenin signaling pathway. PMID: 19923077 [PubMed - as supplied by publisher] (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - November 20, 2009 Category: Universities & Medical Training Authors: Niu LG, He JJ, Wang K, Zhang W, Zhou C Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: journals

Columnar cell lesions and pseudoangiomatous hyperplasia like stroma: is there an epithelial-stromal interaction?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The significance of association between cancer and its microenvironment has been increasingly recognized. It has been shown in animal models that interaction between neoplastic epithelial cells and adjacent stroma can modulate tumor behavior. Carcinoma associated stromal cells can transform normal epithelial cells into neoplastic cells. In breast, columnar cell lesions are non-obligate precursors of low grade ductal carcinoma in situ. Columnar cell lesions can be seen intimately associated with PASH-like-stroma, a lesion we termed as CCPLS. Our aim is to investigate epithelial-stromal interactions in CCPLS and compare ...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Recavarren RA, Chivukula M, Carter G, Dabbs DJ Tags: Int J Clin Exp Pathol Source Type: journals

Early Response to Neo-adjuvant Chemotherapy in Carcinoma of the Breast Predicts Both Successful Breast-Conserving Surgery and Decreased Risk of Ipsilateral Breast Tumor RecurrenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the early response to neo-adjuvant chemotherapy may be a useful predictor of both selection of surgical method and IBTR risk. (Source: The Breast Journal)
Source: The Breast Journal - November 19, 2009 Category: Cancer & Oncology Authors: Makoto Ishitobi, Yoshifumi Komoike, Kazuyoshi Motomura, Hiroki Koyama, Hideo Inaji Source Type: journals

Clinical Implications of Subcategorizing BI-RADS 4 Breast Lesions associated with Microcalcification: A Radiology–Pathology Correlation StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Currently radiologists have the option of subcategorizing BI-RADS 4 breast lesions into 4A (low suspicion for malignancy), 4B (intermediate suspicion of malignancy), and 4C (moderate concern, but not classic for malignancy). To determine the clinical significance of BI-RADS 4 subcategories and the common pathologic changes associated with these mammographic lesions, a retrospective review of 239 consecutive stereotactic-needle core biopsies (SNCB) for microcalcifications was performed. All 239 SNCBs were BI-RADS 4 lesions, and of these, 191 were subcategorized to 4A, 4B or 4C. Ninety-four of 191 (49%) were 4A, 73...
Source: The Breast Journal - November 19, 2009 Category: Cancer & Oncology Authors: Mary Ann Sanders, Lane Roland, Sunati Sahoo Source Type: journals

Magnetic Resonance Imaging Screening of the Contralateral Breast in Women With Newly Diagnosed Breast Cancer: Systematic Review and Meta-Analysis of Incremental Cancer Detection and Impact on Surgical Management [REVIEW ARTICLE]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion MRI detects contralateral lesions in a substantial proportion of women, but does not reliably distinguish benign from malignant findings. Relatively high ICDR may be due to selection bias and/or overdetection. Women must be informed of the uncertain benefit and potential harm, including additional investigations and surgery. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Brennan, Houssami, Lord, Macaskill, Irwig, Dixon, Warren, Ciatto Tags: Diagnosis & Staging REVIEW ARTICLE Source Type: journals

Effect of alpha tocopherol acetate in Walker 256/B cells-induced oxidative damage in a rat model of breast cancer skeletal metastases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The pathophysiological changes and the oxidative-antioxidative status were evaluated in the bone microenvironment of rat inoculated with Walker 256/B mammary gland carcinoma cells, and used alpha-tocopherol acetate (ATA) as a countermeasure. Walker 256/B cells were injected into the right femora of aged male rats. Animals were randomized into three groups: 12 rats were injected with saline (control group); 14 rats were injected with Walker 256/B cells (5x10(4)) in the medullar cavity (W256 group); 14 rats were inoculated with Walker 256/B cells and treated with ATA (45mg/kg BW) (W256+ATA group). After 20 days, rats wer...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Badraoui R, Blouin S, Moreau MF, Gallois Y, Rebai T, Sahnoun Z, Baslé M, Chappard D Tags: Chem Biol Interact Source Type: journals

Extrapulmonary small cell carcinoma in breast and prostateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the evolution of two cases. Content Type Journal ArticleCategory Case ReportsDOI 10.1007/s12094-009-0427-6Authors Juan Quirós Rivero, Hospital Universitario Infanta Cristina Radiation Oncology Service Avda. de Elvas, s/n ES-06006 Badajoz SpainJulia Luisa Muñoz García, Hospital Universitario Infanta Cristina Radiation Oncology Service Avda. de Elvas, s/n ES-06006 Badajoz SpainJoaquín José Cabrera Rodríguez, Hospital Universitario Infanta Cristina Radiation Oncology Service Avda. de Elvas, s/n ES-06006 Badajoz SpainJosé Antonio González Ferreira, Hospital Universitario Infanta Cristina Radiation Oncol...
Source: Clinical and Translational Oncology - November 18, 2009 Category: Cancer & Oncology Tags: Clinical and Translational Oncology Source Type: journals

Declining recurrence among ductal carcinoma in situ patients treated with breast-conserving surgery in the community settingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The marked increase in the 1990s in the use of adjuvant therapy for DCIS patients treated with BCS in the community setting only partially explains the 50% decline in risk of recurrence risk. Changes in pathology factors have likely also contributed to this decline. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 18, 2009 Category: Cancer & Oncology Authors: Laurel HabelNinah AchacosoReina HaqueLarissa NekhlyudovSuzanne FletcherStuart SchnittLaura CollinsAnn GeigerBalaram PuligandlaLuana ActonCharles Quesenberry Source Type: journals

Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment StrategyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. From our data, postirradiation sarcoma should not be managed differently from primary sarcoma. Chemotherapy has to be included in the treatment plan of postirradiation sarcoma, in future studies. (Source: Sarcoma)
Source: Sarcoma - November 17, 2009 Category: Cancer & Oncology Source Type: journals

Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Similar to adenomas, MGA is, at least in some cases, a clonal lesion and may be a non-obligate precursor of a subgroup of high-grade triple-negative and basal-like breast carcinomas. (Source: Histopathology)
Source: Histopathology - November 17, 2009 Category: Pathology Authors: Felipe C Geyer, Yael B Kushner, Maryou B Lambros, Rachael Natrajan, Alan Mackay, Narinder Tamber, Kerry Fenwick, Dave Purnell, Alan Ashworth, Rosemary A Walker, Jorge S Reis-Filho Source Type: journals

Chromogenic in situ hybridization for Her-2/neu-oncogene in breast cancer: comparison of a new dual-colour chromogenic in situ hybridization with immunohistochemistry and fluorescence in situ hybridizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CISH, using dual-colour probes (ZytoVision®) is as good as FISH for Her-2/neu analysis. The few discrepant results are likely to be caused by polysomy or tumour heterogeneity. (Source: Histopathology)
Source: Histopathology - November 17, 2009 Category: Pathology Authors: Doris Mayr, Sibylle Heim, Kerstin Weyrauch, Evelyn Zeindl-Eberhart, Anne Kunz, Jutta Engel, Thomas Kirchner Source Type: journals

Skin metastasis: a pathologist's perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study presents a literature review concerning these issues as well as this author's experience encountered throughout 19 years of surgical pathology and dermatopathology practice. Several conclusions are evident. Generally, skin metastases are encountered in 0.7[ndash]9% of all patients with cancer and as such the skin is an uncommon site of metastatic disease when compared to other organs. There is usually a long-time lag between the diagnosis of the primary malignancy and the recognition of the skin metastases. However, these metastases may be the first indication of the clinically silent visceral malignancies. The ...
Source: Journal of Cutaneous Pathology - November 17, 2009 Category: Pathology Authors: Mahmoud Rezk Abdelwahed Hussein Source Type: journals

Fusion genes and chromosome translocations in the common epithelial cancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It has been known for 25 years that fusion genes play a central role in leukaemias and sarcomas but they have been neglected in the common carcinomas, largely because of technical limitations of cytogenetics. In the last few years it has emerged that gene fusions, caused by chromosome translocations, inversions, deletions, etc., are important in the common epithelial cancers, such as prostate and lung carcinoma. Most prostate cancers, for example, have an androgen-regulated fusion of one of the ETS transcription factor gene family. Early results of genome-wide searches for gene fusions in breast and other epithelial cancer...
Source: The Journal of Pathology - November 17, 2009 Category: Pathology Authors: Paul AW Edwards Source Type: journals

3,5,3′,4′,5′-Pentamethoxystilbene (MR-5), a Synthetically Methoxylated Analogue of Resveratrol, Inhibits Growth and Induces G1 Cell Cycle Arrest of Human Breast Carcinoma MCF-7 CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Agricultural and Food Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - November 16, 2009 Category: Food Science Tags: article Source Type: journals

Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study of 108 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The differences in the expression of cyclin D1 and retinoblastoma may indicate the differences in the pathogenesis of PDV and PDB. (Source: Histopathology)
Source: Histopathology - November 16, 2009 Category: Pathology Authors: Patricia E Ellis, Allan B MacLean, Julie C Crow, L F Wong Te Fong, Kerstin J Rolfe, Christopher W Perrett Source Type: journals

Concordant HER2 status between metastatic breast cancer cells in CSF and primary breast cancer tissueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract It is not known whether the HER2 status of malignant CSF cells coincides with that of the original breast carcinoma cells. We investigated whether CSF cytology specimens were suitable to evaluate HER2 status by fluorescence in situ hybridization (FISH) in patient with leptomeningeal metastasis (LM). Both formalin-fixed paraffin-embedded (FFPE) breast cancer tissue and liquid based CSF cytology specimens were evaluated for HER2 status in 16 patients with LM. We evaluated HER2 gene amplification using FISH on destained CSF cytology slides containing a minimum of 20 malignant cells per slide, and compa...
Source: Breast Cancer Research and Treatment - November 14, 2009 Category: Cancer & Oncology Tags: breast Cancer Research and Treatment Source Type: journals

Expression of metalloproteases and their inhibitors in different histological types of breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We found variations in MMP/TIMP expressions among the different histological subtypes of breast carcinomas suggesting differences in their tumor pathophysiology Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-0721-2Authors J. M. Del Casar, Fundación Hospital de Jove Unidad de Investigación Avda. Eduardo Castro s/n 33290 Gijón Asturias SpainS. González-Reyes, Fundación Hospital de Jove Unidad de Investigación Avda. Eduardo Castro s/n 33290 Gijón Asturias SpainL. O. González, Fundación Hospital de Jove Unidad de Investigación Avda. Eduardo Castro s/n 33290 ...
Source: Journal of Cancer Research and Clinical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Avoiding Axillary Treatment in Sentinel Lymph Node Micrometastases of Breast Cancer: A Prospective Analysis of Axillary or Distant RecurrenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Breast cancer patients with SLN micrometastases in whom ALND was omitted had a very low locoregional failure rate. This study supports the theory that ALND might be avoided in these patients, providing that adjuvant systemic treatment equal to treatment provided to treat node-positive disease is administered. However, longer follow-up and results of additional prospective studies are needed. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-009-0804-yAuthors Sonia Pernas, Institut Català d’Oncologia Medical Oncology Department L’Hospitalet Barcelona SpainMarta Gi...
Source: Annals of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells [Research Articles]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we found that Compound C treatment of MCF7 cells led to Bax redistribution from the cytoplasm to mitochondria and cell death. However, this effect does not involve AMPK. In addition, we found that treatment with this compound leads to an enhanced ceramide production. Analyses by quantitative PCR and ceramide synthase activity assay suggest that ceramide synthase 5 (LASS/CerS 5) is involved in Compound C-induced ceramide upregulation. Downregulation of LASS/CerS 5 was found to attenuate Compound C-mediated ceramide production, Bax redistribution, and cell death. (Source: The Journal of Lipid Research)
Source: The Journal of Lipid Research - November 13, 2009 Category: Lipidology Authors: Jin, J., Mullen, T. D., Hou, Q., Bielawski, J., Bielawska, A., Zhang, X., Obeid, L. M., Hannun, Y. A., Hsu, Y.-T. Tags: Research Articles Source Type: journals

Durable tumour responses following primary high-dose induction with mistletoe extracts: Two case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mobilising the host's innate defences against established cancer and residual disease is an attractive and rational therapeutic approach to treat solid tumours and their known and occult metastases, from which relapses occur. Over the last decades significant progress has been made in understanding the immunological mechanisms that develop in relationship between the host and a developing tumour. However, the effectiveness of immunotherapy in humans remains quite limited. Tumours have robust mechanisms that disable tumour-specific immunity. It is generally accepted that an effective anti-tumour response of the immune syste...
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: M. Orange, A. Lace, M. Fonseca, H.B. von Laue, S. Geider Source Type: journals

Excision alone inadequate for high grade DCISEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Excision alone is inadequate treatment for patients with high-grade ductal carcinoma in situ, but may be suitable for patients with low- or intermediate-grade lesions, US study findings indicate. (Source: MedWire News - Breast Cancer)
Source: MedWire News - Breast Cancer - November 13, 2009 Category: Cancer & Oncology Source Type: news

A remarkable case of cutaneous metastatic breast carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 50-year-old woman with a 5-month history of multiple asymptomatic papulonodular lesions on the left chest area. Biopsy was consistent with cutaneous metastases from a ductal breast carcinoma. No distant metastatic lesions were detected. The patient was referred to the Gynecologic Oncology Department. Treatment included chemotherapy, radiotherapy and surgery. At present the patient is well with no signs of recurrence. This case reports a clinically remarkable cutaneous metastatic breast carcinoma. PMID: 19903438 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - November 13, 2009 Category: Dermatology Authors: Santiago F, Saleiro S, Brites MM, Frutuoso C, Figueiredo A Tags: Dermatol Online J Source Type: journals

Effect of comorbidity on urinary neopterin in patients with breast carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, present data demonstrate an association between systemic immune activation reflected in increased urinary neopterin concentrations and age or presence of comorbid diseases in patients with breast carcinoma. A cumulative effect was observed with the presence of two or more comorbid conditions resulting in significantly increased urinary neopterin. These observations should be taken into account when interpreting the changes of parameters of systemic immune and inflammatory response in patients with breast carcinoma. (Source: European Journal of Cancer Care)
Source: European Journal of Cancer Care - November 13, 2009 Category: Cancer & Oncology Authors: K. MELICHAROVÁ, H. KALÁBOVÁ, L. KRČMOVÁ, L. URBÁNEK, D. SOLICHOVÁ, B. MELICHAR Source Type: journals

Absence of transforming growth factor-{beta} type II receptor is associated with poorer prognosis in HER2-negative breast tumours.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: To the best of our knowledge, this is the first report indicating the relevance of HER2 status in discriminating TGF-betaRII as a prognostic marker for DFS and OS in human BC. These data indicate that TGF-betaRII protein analysis in tumour cells could be introduced in clinical practice as additional prognostic biomarker in HER2-negative BC. PMID: 19914962 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - November 13, 2009 Category: Cancer & Oncology Authors: Paiva CE, Drigo SA, Rosa FE, Moraes Neto FA, Caldeira JR, Soares FA, Domingues MA, Rogatto SR Tags: Ann Oncol Source Type: journals

Can breast MRI computer-aided detection (CAD) improve radiologist accuracy for lesions detected at MRI screening and recommended for biopsy in a high-risk population?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The breast MRI CAD system used could not improve the radiologists' accuracy for distinguishing all malignant from benign lesions, due to the poor sensitivity for DCIS detection. (Source: Clinical Radiology)
Source: Clinical Radiology - November 12, 2009 Category: Radiology Authors: T. Arazi-Kleinman, P.A. Causer, R.A. Jong, K. Hill, E. Warner Tags: Original Articles Source Type: journals

Over Expression of RhoA is Associated with Progression in Invasive Breast Duct CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The Breast Journal)
Source: The Breast Journal - November 12, 2009 Category: Cancer & Oncology Authors: Li Ma, Yue-ping Liu, Cui-zhi Geng, Xiao-ling Wang, Yong-jun Wang, Xiang-hong Zhang Source Type: journals

Comparative study of the immunohistochemical expression of metalloproteinases 2, 7and 9between clearly invasive carcinomas and "in situ" trophoblast invasion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, although there seems to be adirect link between cancer invasion and MMP9 immunohistochemical expression, the role of MMP2 and MMP7 appears to be more complicated underlining the complexity of the mechanisms involved in cancer spreading. Keywords: PMID: 19895168 [PubMed - in process] (Source: Neoplasma)
Source: Neoplasma - November 11, 2009 Category: Cancer & Oncology Authors: Ioannidis I, Dimo B, Karameris A, Vilaras G, Gakiopoulou H, Patsouris E, Lazaris AC Tags: Neoplasma Source Type: journals

[Radiofrequency ablation of breast carcinomas: preliminary results of a clinical trial.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Radiofrequency ablation of breast carcinomas is feasible, well tolerated, safe, and efficacious in nearly 90% of invasive tumors. The efficacy of the technique should be confirmed through extended follow-up of patients without subsequent surgical intervention in carefully designed and monitored phase III trials. PMID: 19913265 [PubMed - as supplied by publisher] (Source: Radiologia)
Source: Radiologia - November 11, 2009 Category: Radiology Authors: Apesteguía L, Ovelar A, Domínguez-Cunchillos F, Alfaro C, Trujillo R, Sanz MA, de Miguel C, Reparaz B, Ruiz de Azúa Y Tags: Radiologia Source Type: journals

Inferring tumor progression from genomic heterogeneity [METHODS AND RESOURCES]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cancer progression in humans is difficult to infer because we do not routinely sample patients at multiple stages of their disease. However, heterogeneous breast tumors provide a unique opportunity to study human tumor progression because they still contain evidence of early and intermediate subpopulations in the form of the phylogenetic relationships. We have developed a method we call Sector-Ploidy-Profiling (SPP) to study the clonal composition of breast tumors. SPP involves macro-dissecting tumors, flow-sorting genomic subpopulations by DNA content, and profiling genomes using comparative genomic hybridization (CGH). B...
Source: Genome Research - November 10, 2009 Category: Genetics & Stem Cells Authors: Navin, N., Krasnitz, A., Rodgers, L., Cook, K., Meth, J., Kendall, J., Riggs, M., Eberling, Y., Troge, J., Grubor, V., Levy, D., Lundin, P., Maner, S., Zetterberg, A., Hicks, J., Wigler, M. Tags: METHODS AND RESOURCES Source Type: journals

Basal levels of DNA damage detected by micronuclei and comet assays in untreated breast cancer patients and healthy womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the present work demonstrates higher levels of DNA damage in untreated breast cancer patients than in healthy women. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10238-009-0079-4Authors Raquel A. Santos, University of São Paulo Department of Genetics, Faculty of Medicine of Ribeirão Preto Bloco G. Av. Bandeirantes Ribeirão Preto SP 3900 BrazilAna Cláudia Teixeira, University of São Paulo Department of Genetics, Faculty of Medicine of Ribeirão Preto Bloco G. Av. Bandeirantes Ribeirão Preto SP 3900 BrazilMonica B. Mayorano, University of São Paulo Department of Genetics, Facu...
Source: Clinical and Experimental Medicine - November 10, 2009 Category: Research Tags: Clinical and Experimental Medicine Source Type: journals

Conservative surgery with and without radiotherapy in elderly patients with early-stage breast cancer: A prospective randomised multicentre trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breast conserving therapy (BCT) including postoperative irradiation of the remaining breast tissue is generally accepted as the best treatment for the majority of patients with early-stage breast cancer. The question is whether there is a necessity for irradiating all patients. Between 2001 and 2005, 749 women aged 55-75 years with infiltrating breast carcinoma were randomly assigned to breast conservative surgery, with or without radiotherapy (RT), to evaluate the incidence of in-breast recurrence (IBR). After 5 years of median follow-up, the cumulative incidence of IBR was 2.5% in the surgery-only arm and 0.7% in the...
Source: Breast - November 10, 2009 Category: Cancer & Oncology Authors: Tinterri C, Gatzemeier W, Zanini V, Regolo L, Pedrazzoli C, Rondini E, Amanti C, Gentile G, Taffurelli M, Fenaroli P, Tondini C, Sacchetto G, Sismondi P, Murgo R, Orlandi M, Cianchetti E, Andreoli C Tags: breast Source Type: journals

A unique proteolytic fragment of alpha1-antitrypsin is elevated in ductal fluid of breast cancer patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, elevated C-41/42 is likely the result of elevated AAT synthesis, and the activity of specific MMPs present within the tumor. As other C-terminal fragments of AAT are reported to function as tumor-derived suppressors to the host immune-system, elevated C-41/42 may also be predictive of a poor outcome. Content Type Journal ArticleCategory Preclinical studyDOI 10.1007/s10549-009-0625-5Authors Junma Zhou, Johns Hopkins Medical Institutions Department of Pathology Baltimore MD 21287 USABruce Trock, Johns Hopkins Medical Institutions Department of Urology Baltimore MD 21287 USATheodore N. Tsangaris, Johns H...
Source: Breast Cancer Research and Treatment - November 9, 2009 Category: Cancer & Oncology Tags: breast Cancer Research and Treatment Source Type: journals

From normal cell types to malignant phenotypesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The phenotypic diversity of breast cancer has been proposed to result from different target cell types undergoing oncogenic transformation and giving rise to cancer stem cells (CSCs). Global gene expression profiling revealed distinct molecular phenotypes and some of these signatures were held to reflect the cell of origin with the basal carcinomas arising from basal/progenitor cells. Recent work challenges this view by providing evidence that luminal precursor cells are involved in the pathogenesis of basal breast cancers and made new links between normal cell populations and molecular tumor phenotypes. (Source: Breast Cancer Research)
Source: Breast Cancer Research - November 9, 2009 Category: Cancer & Oncology Authors: Özden Yalcin-OzuysalCathrin Brisken Source Type: journals

Epithelial to Mesenchymal Transition and Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a cohesive secondary mass at a metastatic site. Understanding of the underlying molecular and cellular processes in breast cancer is advancing- they are transcriptionally and epigenetically regulated, can be monitored using an increasing array of marker proteins, and result in characteristic changes in cell behavior. Such plasticity has implications in progression of breast carcinoma to metastasis, and will likely influe...
Source: Breast Cancer Research - November 9, 2009 Category: Cancer & Oncology Authors: Eva Tomaskovic-CrookErik ThompsonJean Paul Thiery Source Type: journals

Comparison of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) assessment for Her-2 status in breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a prospective study to reflect the concordance between IHC and FISH in Guilin city, People's Republic of China. Methods: Fifty cases of invasive ductal carcinoma of breast tested by IHC and scored as 0, 1+, 2+ and 3+ by pathologists were further analyzed by FISH using a commercially available double-color probe, and the FISH findings were compared with IHC testresults. Results: A total concordance of 82.0% was observed with a Kappa coefficient of 0.640 (P (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - November 9, 2009 Category: Cancer & Oncology Authors: Weiguo SuiMinglin OuJiejing ChenYouhua WanHongbo PengMinfang QiHe HuangYong Dai Source Type: journals

Multiple primary malignancies in patients with Merkel cell carcinoma1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our figures reflect a higher incidence of multiple malignancies in those with Merkel cell tumour than has previously been reported. This has important implications for the care and surveillance of these patients. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - November 9, 2009 Category: Dermatology Authors: JK Gass, SK Chan, E Rytina, DC Greenberg, NP Burrows Source Type: journals

Breast Cancer Deception Month: Hiding the Truth beneath a Sea of Pink, Part VEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) As we near the end of Breast Cancer Awareness Month, once again our country has been awash from shore to shore in a sea of pink - from pink ribbons and donation boxes to pink products, charity promotions, celebrities by the score and even pink cleats on NFL players. Tragically, most people are unaware of the dark history of Breast Cancer Awareness Month (BCAM) and of the players past and present who have misused it to direct people and funds away from finding a true cure, while covering up their own roles in causing and profiting from cancer.In this installment of the series, we will examine the dangers of ov...
Source: NaturalNews.com - November 8, 2009 Category: Consumer Health Advice Source Type: news

GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we determined that GM-CSF was one of the tumor-derived soluble factors that induced differentiation of CD11b-Gr1- progenitor cells from within monocytic/granulocytic bone marrow cells into CD11b+Gr1+ cells. We also showed that CD11b+Gr1+ cells in FVBN202 mice consisted of CD11b+Ly6G-Ly6C+ suppressive and CD11b+Ly6G+Ly6C+ non-suppressive subsets. Previously reported variations between tumor-free and tumor-bearing animals in the function of their CD11b+Gr1+ cells were found to be due to the variations in the proportion of these two subsets. Therefore, increasing ratios of CD11b+Gr1+ cells derived from tumo...
Source: Breast Cancer Research and Treatment - November 7, 2009 Category: Cancer & Oncology Tags: breast Cancer Research and Treatment Source Type: journals

Local Excision Alone Without Irradiation for Ductal Carcinoma In Situ of the Breast: A Trial of the Eastern Cooperative Oncology Group [Breast Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Rigorously evaluated and selected patients with low- to intermediate-grade DCIS with margins 3 mm or wider had an acceptably low rate of ipsilateral breast events at 5 years after excision without irradiation. Patients with high-grade lesions had a much higher rate, suggesting that excision alone is inadequate treatment. Further follow-up is necessary to document long-term results. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Authors: Hughes, Wang, Page, Gray, Solin, Davidson, Lowen, Ingle, Recht, Wood Tags: Combined Modality breast Cancer Source Type: journals

Analysis of the expression of hyaluronan in intraductal and invasive carcinomas of the breastEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our study indicates a proportionally higher area of hyaluronan expression in DCIS with a microinvasive component than in pure DCIS, suggesting a key role of this glycosaminoglycan in the early invasive phase of breast carcinomas. Thus, hyaluronan could play an important function in determining the migratory phenotype of cancer cells. Larger size tumors appear to demonstrate an intricate balance between hyaluronan synthesis and degradation, thus conditioning intratumoral heterogeneity in the hyaluronan metabolism. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-009-071...
Source: Journal of Cancer Research and Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Expression of E-cadherin, Snail and Hakai in epithelial cells isolated from the primary tumor and from peritumoral tissue of invasive ductal breast carcinomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19893985 [PubMed - as supplied by publisher] (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - November 6, 2009 Category: Research Authors: Makdissi FB, Machado LV, Oliveira AG, Benvenuti TT, Katayama ML, Brentani MM, Osório CA, Mourão Netto M, Lyra EC, Carvalho F, Góes JC, Folgueira MA Tags: Braz J Med Biol Res Source Type: journals

Ductal Carcinoma In Situ — A Highly Treatable Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Doctors and their patients with a specific type of breast cancer called ductal carcinoma in situ (DCIS) are successfully employing treatments to beat the disease, with 10-year survival rates approaching nearly 100 percent. (Source: Mayo Clinic Health Information)
Source: Mayo Clinic Health Information - November 5, 2009 Category: Consumer Health Advice Authors: Mayo Clinic Source Type: organizations