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Infarcted fibroadenoma of the breast: report of two
new cases with review of the literature
Conclusion: Spontaneous infarction within fibroadenoma is a rare phenomenon in younger patients. Thepresence of necrosis on core biopsy or frozen section should be cautiously interpreted and isnot a sign of malignancy.Virtual slidesThe virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/1556060549847356 (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - February 27, 2013 Category: Pathology Authors: Faruk SkenderiFikreta KrakonjaSemir Vranic Source Type: research
Invasive Micropapillary Carcinoma of the Breast: Imaging Features With Clinical and Pathologic Correlation
CONCLUSION. The imaging features of invasive ductal carcinoma of the breast with micropapillary features typically were highly suggestive of malignancy. The malignancies were strongly associated with lymphovascular invasion and lymph node metastases. Radiologists should be aware of the imaging features of this unusual variant and should consider axillary sonography if this entity is found in a core needle biopsy specimen. (Source: American Journal of Roentgenology)
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Jones, K. N., Guimaraes, L. S., Reynolds, C. A., Ghosh, K., Degnim, A. C., Glazebrook, K. N. Tags: Women ' s Imaging Source Type: research
Intrathecal Chemotherapy (Part II): Changes in Procedures and Technique. Evaluation of Results (P01.100)
CONCLUSIONS: There was a low rate of side effects, all minor and with full resolution. The IT-ChT technique here described was safe.Supported by: Scholarship Peruilh-Menvielle, School of Medicine, University of Buenos Aires.Disclosure: Dr. Báez has nothing to disclose. Dr. Baez has nothing to disclose. Dr. Kuchkaryan has nothing to disclose. Dr. Tafur Canabal has nothing to disclose. Dr. Igirio Gamero has nothing to disclose. Dr. Gonzalez Roffo has nothing to disclose. Dr. Torres has nothing to disclose. Dr. Caffaro has nothing to disclose. Dr. Campanucci has nothing to disclose. Dr. Hurevich has nothing to disclose...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Baez, A., Baez, M., Kuchkaryan, V., Tafur Canabal, J., Igirio Gamero, J., Gonzalez Roffo, A., Torres, Z., Caffaro, M., Campanucci, V., Hurevich, P., Casas-Parera, I. Tags: P01 Neuro-Oncology: Therapeutics Source Type: research
Hysterectomy After Childbirth – Laura’s Story
My name is Laura Boot-Handford and I recently turned 30. I grew up in the beautiful town Lewes, East Sussex. I met my Husband there whilst at college. We both went to University in Leicester and settled in Northampton nearby once we had finished. We bought our first house and two cats. We got married and soon thought about starting a family of our own.I was 27 when we had our first son, Harry. I had a consultant led pregnancy as I have Addisons, although I rarely saw the consultant. I started to get high blood pressure and traces of protein in my urine which was indicating the onset of pre eclampsia so the registrar deci...
Source: The Hysterectomy Association - February 13, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Post Birth Your Stories childbirth postpartum haemorrhage Womb transplant Source Type: news
Outcome of pure mucocele‐like lesions diagnosed on breast core biopsy
ConclusionsOur results provide evidence that pure MLL without atypia diagnosed on NCB is usually associated with a benign outcome. (Source: Histopathology)
Source: Histopathology - February 12, 2013 Category: Pathology Authors: Emad A Rakha, Abeer M Shaaban, Syeda Asma Haider, Jacquie Jenkins, Sindhu Menon, Christopher Johnson, Rin Yamaguchi, Alison Murphy, Joyce Liston, Eleanor Cornford, Lisa Hamilton, Jonathan James, Ian O Ellis, Andrew H S Lee Tags: Original Article Source Type: research
Undifferentiated pleomorphic sarcoma with osteoclast-like giant cells of the female breast
The authors describe a case of undifferentiated pleomorphic sarcoma of the breast occurring in a 50-year-old woman who presented with a palpable mass in her right breast. She first noticed the mass one month previously. Core needle biopsy showed connective tissue including epithelioid and spindle cells. The patient underwent total mastectomy without axillary lymph node dissection. Based on examination of the excised tumor, the initial pathologic diagnosis was atypical spindle-shaped and ovoid cells with uncertain malignant potential. Histological findings with immunomarkers led to the final diagnosis of undifferentiated pl...
Source: World Journal of Surgical Oncology - January 26, 2013 Category: Cancer & Oncology Authors: Giancarlo BalbiLuca MartinoGianPaolo PitruzzellaDiego PitruzzellaFlavio GrausoAntonella NapolitanoElisabetta SeguinoFrancesco GioiaPasquale Orabona Source Type: research
Medullary breast carcinoma in an 18‐year‐old female report on one case diagnosed on fine‐needle cytology sample
Abstract Medullary breast carcinoma (MBC) is a rare epithelial malignancy of the breast accounting for about 1–7% of all breast carcinomas. It is characterized by well‐defined borders, a syncytial/solid pattern of growth of high grade atypical cells showing no glandular differentiation and a massive diffuse lympho‐plasmacytic peritumoral infiltrate. Despite the high‐grade atypias characterizing this neoplasm, MBC has been reported to have a better prognosis when compared with the common infiltrating duct carcinoma. MBCs typically lack estrogen and progesterone receptor (ER and PgR) expression and have a low inciden...
Source: Diagnostic Cytopathology - January 22, 2013 Category: Pathology Authors: Antonio Galzerano, Nicola Rocco, Antonello Accurso, Giuseppe Ciancia, Anna Cipolletta Campanile, Ferdinando Caccavello, Franco Fulciniti Tags: Brief Report Source Type: research
Role of Acoustic Shear Wave Velocity Measurement in Characterization of Breast Lesions
Conclusions Acoustic radiation force impulse imaging has potential to characterize breast lesions, both internally and within the boundary zone, and to reflect changes in stiffness within surrounding glandular and subcutaneous fatty tissues caused by malignant tumors. (Source: Journal of Ultrasound in Medicine)
Source: Journal of Ultrasound in Medicine - January 22, 2013 Category: Radiology Authors: Zhou, J., Zhan, W., Chang, C., Zhang, J., Yang, Z., Dong, Y., Zhou, C., Song, Y. Tags: Original Research Source Type: research
Clinical Experience With Elasticity Imaging in a Community-Based Breast Center
Conclusions In this study, elasticity imaging had high sensitivity for malignant and benign lesions. Elasticity imaging in the clinical setting may prove to be an additional tool that is helpful to the breast clinician for characterization of lesions as benign or malignant. At this time, we are continuing our data collection because additional research is still necessary. (Source: Journal of Ultrasound in Medicine)
Source: Journal of Ultrasound in Medicine - January 22, 2013 Category: Radiology Authors: Destounis, S., Arieno, A., Morgan, R., Murphy, P., Seifert, P., Somerville, P., Young, W. Tags: Original Research Source Type: research
Comparison of Sonographically Guided Core Needle Biopsy and Excision in Breast Papillomas: Clinical and Sonographic Features Predictive of Malignancy
Conclusions Prediction of papilloma with atypia, not malignancy, was challenging because there were no associated clinical or radiologic factors to predict papilloma with atypia before excision. However, there was no malignancy after excision. Therefore, intensive surveillance is preferable to immediate surgical excision for benign papillomas diagnosed on core needle biopsy. (Source: Journal of Ultrasound in Medicine)
Source: Journal of Ultrasound in Medicine - January 22, 2013 Category: Radiology Authors: Sohn, Y.-M., Park, S. H. Tags: Original Research Source Type: research
Biomarker Analysis of Neoadjuvant Doxorubicin/Cyclophosphamide Followed by Ixabepilone or Paclitaxel in Early-stage Breast Cancer.
CONCLUSION: These results indicate that βIII-tubulin protein and mRNA expression, MDR1 protein expression, TACC3 and CAPG gene expression, and multi-gene expression models (20- and 26-gene) are not predictive markers for differentiating treatment benefit between ixabepilone and paclitaxel in early-stage breast cancer. PMID: 23340299 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - January 22, 2013 Category: Cancer & Oncology Authors: Horak CE, Pusztai L, Xing G, Trifan OC, Saura C, Tseng LM, Chan S, Welcher R, Liu D Tags: Clin Cancer Res Source Type: research
Incidental Intraductal Papillomas (
Abstract Most authors recommend excision of intraductal papillomas diagnosed on core needle biopsy. This leads to the question of whether or not excision is necessary for incidental intraductal papillomas on core needle biopsy as opposed to those corresponding to imaging findings. Using the pathology computerized data base we retrospectively identified 46 incidental intraductal papillomas diagnosed on core needle biopsy from 1/2000 to 12/2008. Clinical, radiologic, and pathologic information was gathered and correlated. All core needle biopsies were reviewed to confirm the diagnosis of incidental intraductal papillomas, an...
Source: The Breast Journal - January 21, 2013 Category: Cancer & Oncology Authors: Shabnam Jaffer, Ira J. Bleiweiss, Chandandeep Nagi Tags: Original Article Source Type: research
Large Core Needle Biopsy with Tomosynthesis Guidance: Another Development in Breast Imaging Technology
(Source: The Breast Journal)
Source: The Breast Journal - January 10, 2013 Category: Cancer & Oncology Authors: D David Dershaw Tags: Editorial Source Type: research
New mutation in the PTEN gene in a Brazilian patient with Cowden's syndrome
Cowden syndrome is characterized by hamartomatous polyps, trichilemmomas, increased risk of developing neoplasms, and is associated with germline mutations in the PTEN gene. We searched for germline mutations in PTEN in a 49-year-old female patient who presented trichilemmoma with previous history of breast carcinoma, and thyroidectomy for a thyroid nodule. We also searched for somatic mutations in breast and thyroid tumoral tissues. DNA was extracted from peripheral leukocytes, paraffin samples of breast carcinoma, and cytological smears of thyroid nodule fine-needle aspiration biopsy, whose final histopathological diagno...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 8, 2013 Category: Endocrinology Source Type: research
Reflectance spectra detect breast calcifications [Applied Biological Sciences]
Microcalcifications geographically target the location of abnormalities within the breast and are of critical importance in breast cancer diagnosis. However, despite stereotactic guidance, core needle biopsy fails to retrieve microcalcifications in up to 15% of patients. Here, we introduce an approach based on diffuse reflectance spectroscopy for detection of microcalcifications... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - January 8, 2013 Category: Science Authors: Soares, J. S., Barman, I., Dingari, N. C., Volynskaya, Z., Liu, W., Klein, N., Plecha, D., Dasari, R. R., Fitzmaurice, M. Tags: Biological Sciences Source Type: research
Necrotizing Infection of the Breast after Core Needle Biopsy
(Source: The Breast Journal)
Source: The Breast Journal - January 7, 2013 Category: Cancer & Oncology Authors: Dario R. Roque, Shannon MacLaughlan, Trevor Tejada‐Berges Tags: Breast Images Source Type: research
Abstract: Cellular pathology is a key component of the breast disease multidisciplinary team, representing the ‘gold standard’ in the diagnosis of breast cancer and providing crucial information for determination of prognosis and management. Material may be obtained for pathological examination using fine needle aspiration (FNA) cytology, needle core biopsy or surgical excision (histopathology). Common benign conditions include fibrocystic change, fibroadenomas, intraduct papillomas and radial scars. Carcinoma is by far the most common malignant tumour and may exist as in situ or invasive forms. The use of mammography ...
Source: Surgery (Medicine Publishing) - January 1, 2013 Category: Surgery Authors: Adrian C. Bateman, Emily C. Shaw Tags: Basic science Source Type: research
The diagnostic utility of the minimal carcinoma triple stain in breast carcinomas.
Abstract Pathologists are expected to accurately diagnose increasingly smaller breast carcinomas. Correct classification (ie, lobular vs ductal or in situ vs invasive) directly affects subsequent management, especially when the focus is near a surgical margin or present in a needle core biopsy and is further challenging if the lesion is morphologically ambiguous. We assessed the diagnostic utility of a multiplex, trichromogen immunostain of 3 commonly employed antibodies (CK7, p63, and E-cadherin) developed in our laboratory to evaluate these small lesions. Of the 147 specimens containing minimal (defined as ≤3 m...
Source: American Journal of Clinical Pathology - January 1, 2013 Category: Pathology Authors: Ross DS, Liu YF, Pipa J, Shin SJ Tags: Am J Clin Pathol Source Type: research
Breast fibromatosis mimicking breast carcinoma.
We present the case of a 30-year-old white woman who presented with a palpable mass within the medial portion of her right breast. She reported breast carcinoma in both her paternal grandmother and maternal aunt. Subsequent mammographic and sonographic evaluation demonstrated an irregular solid mass within the posteromedial portion of the right breast. Ultrasound-guided core needle biopsy revealed low-grade myofibroblastic proliferation consistent with breast fibromatosis. The lesion was surgically resected via wide local excision. Follow-up mammograms performed 1 and 2 years after resection demonstrated no radiographic ev...
Source: Baylor University Medical Center Proceedings - January 1, 2013 Category: Universities & Medical Training Authors: Ha KY, Deleon P, Hamilton R Tags: Proc (Bayl Univ Med Cent) Source Type: research
Discordant HER2 Status Between Primary Breast Carcinoma and Recurrent/Metastatic Tumors Using Fluorescence In Situ Hybridization on Cytological Samples
Conclusions HER2 examination on fluorescence in situ hybridization using fine-needle aspiration cytology samples of tumors in recurrent/metastatic sites or disseminated tumor cells in effusion is beneficial, particularly when the primary tumor is not suitable for the testing of HER2 status or negative for HER2 amplification, because aspiration using a needle is technically feasible and not as traumatic as biopsy. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - December 26, 2012 Category: Cancer & Oncology Authors: Arihiro, K., Oda, M., Ogawa, K., Tominaga, K., Kaneko, Y., Shimizu, T., Matsumoto, S., Oda, M., Kurita, Y., Taira, Y. Tags: Pathology, Original Articles Source Type: research
Disseminated tumor cells as selection marker and monitoring tool for secondary adjuvant treatment in early breast cancer. Descriptive results from an intervention study
Conclusions: After docetaxel treatment, the majority of patients experienced disappearance of DTCs. As this is not a randomized trial, the results can be due to effects of adjuvant (docetaxel/endocrine/trastuzumab) treatment and/or limitations of the methodology. The clinical significance of these results awaits mature FU data, but indicates a possibility for clinical use of DTC-status as a residual disease-monitoring tool and as a surrogate marker of treatment response.Trial registration: Clin Trials Gov NCT00248703. (Source: BMC Cancer)
Source: BMC Cancer - December 22, 2012 Category: Cancer & Oncology Authors: Marit SynnestvedtElin BorgenErik WistGro WiedswangKjetil WeydeTerje RisbergChristian KerstenIngvil MjaalandLise VindiCecilie SchirmerJahn NeslandBjørn Naume Source Type: research
Disseminated tumor cells as selection marker and monitoring tool for secondary adjuvant treatment in early breast cancer. Descriptive results from an intervention study.
CONCLUSIONS: After docetaxel treatment, the majority of patients experienced disappearance of DTCs. As this is not a randomized trial, the results can be due to effects of adjuvant (docetaxel/endocrine/trastuzumab) treatment and/or limitations of the methodology. The clinical significance of these results awaits mature FU data, but indicates a possibility for clinical use of DTC-status as a residual disease-monitoring tool and as a surrogate marker of treatment response.Trial registration: Clin Trials Gov NCT00248703. PMID: 23259667 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - December 22, 2012 Category: Cancer & Oncology Authors: Synnestvedt M, Borgen E, Wist E, Wiedswang G, Weyde K, Risberg T, Kersten C, Mjaaland I, Vindi L, Schirmer C, Nesland JM, Naume B Tags: BMC Cancer Source Type: research
False Negative Results in Axillary Lymph Nodes by Ultrasonography and Ultrasonography-Guided Fine-Needle Aspiration in Patients with Invasive Ductal Carcinoma.
Conclusion: More than half of patients with FNALN showed only one metastatic ALN. LVI and high T-stages were the most important factors attributed to FNALN on US and US-FNA in patients with invasive ductal carcinoma. PMID: 23258771 [PubMed - as supplied by publisher] (Source: Ultraschall in der Medizin)
Source: Ultraschall in der Medizin - December 20, 2012 Category: Radiology Authors: Park SH, Kim EK, Park BW, Kim SI, Moon HJ, Kim MJ Tags: Ultraschall Med Source Type: research
Statin-induced decrease in proliferation depends on HMG-CoA reductase expression in breast cancer
Conclusions: HMGCR, the target of statin treatment, was up-regulated in breast cancer samples after atorvastatin treatment. This indicates HMGCR targeting within the tumor, which resulted in increased enzymatic activity. This study supports previous reports of statin-induced anti-proliferative effects in breast cancer, and suggests that HMGCR could be used as a predictive marker for selection of breast cancer patients with beneficial anti-tumoral effects from statin treatment.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr PD03-07. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Bjarnadottir, O., Romero, Q., Bendahl, P.-O., Ryden, L., Rose, C., Loman, N., Uhlen, M., Jirstrom, K., Grabau, D., Borgquist, S. Tags: Poster Discussion 3 - Metformin / Statins Source Type: research
Standardized Assessment of Ki-67 Using Virtual Slides and Automated Analyzer for Breast Cancer Patients: Comparison of Automated and Central/Local Pathology Assessment
Conclusion: The concordance rate of Ki-67 in preoperative core needle biopsy and surgical specimens was lower compared with other biological markers. However, they were nearly equal with reassessment using central review and an automated analyzer. Clinical application of Ki-67 and its standardization are challenging due to variable counting methods and measurement sites. Conducting central reviews in general clinical facilities is difficult, but introducing an automated analyzer with a Ki-67 labeling index is shown to achieve that goal.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr PD06-02. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Mizuno, Y., Yamada, J., Abe, H., Natori, T., Sato, K. Tags: Poster Discussion 6 - Ki67 Source Type: research
A phase II study of neoadjuvant epirubicin/cyclophosphamide (EC) followed by weekly nanoparticle albumin-bound paclitaxel with or without trastuzumab for node-positive breast cancer
Background: Paclitaxel is considered standard treatment for metastatic breast cancer (MBC) and is often used as adjuvant and neoadjuvant chemotherapy for patients with early-stage disease. Conventional paclitaxel requires solvents such as polyoxyethylated castor oil; however, such solvents are associated with toxicity including peripheral neuropathy and hypersensitivity reaction. Moreover, the use of the drug requires special tubing and in-line filters. Therefore, nanoparticle albumin-bound paclitaxel (nab-PTX) requiring no solvent has been developed. Nab-PTX was effective in patients with MBC and as a neoadjuvant therapy....
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Hirano, A., Hattori, A., Kamimura, M., Ogura, K., Kim, N., Setoguchi, Y., Okubo, F., Inoue, H., Jibiki, N., Miyamoto, R., Kinoshita, J., Kimura, K., Fujibayashi, M., Shimizu, T. Tags: Ongoing Trials 1 - Her2 Source Type: research
Feasibility of sentinel node detection after neoadjuvant chemotherapy for patient with proved axillary lymph node involvement: the French prospective multiinstitutional GANEA 2 ongoing trial
Background: Half of the patient treated with neoadjuvant chemotherapy (NAC) for a large operable breast cancer have no axillary lymph node involvement at the time of surgery. Sentinel lymph node detection (SLND), performed after NAC, would select patient who might be spared of an axillary lymphadenectomy (AL). In a previous study, we assessed the feasibility of SLND after NAC in the case of patients without axillary involvement1. Previous published series have shown that, for patients with an axillary lymph node involvement before treatment, SLND after NAC bring a low detection rate and a high false negative rate (FNR), ma...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Classe, J.-M., Bordes, V., Gimbergues, P., Tunon de Lara, C., Faure, C., Belichard, C., Houpeau, J.-L., Raro, P., Dupre, P.-F., Houvenaeghel, G., Barranger, E., Marchal, F., Deblay, P., Rouanet, P., Lefebvre, C., Bourcier, C., Alran, S. Tags: Ongoing Trials 2 - Surgery / Nodes Source Type: research
A pilot phase ii study to evaluate the impact of denosumab on disseminated tumor cells (dtc) in patients with early stage breast cancer (esbc)
Background: Bone is the most common site of metastases in breast cancer (BC). The detection of keratin + cells (DTC) in bone marrow (BM) has been shown to correlate with an increased risk of disease recurrence. Receptor activator of nuclear factor kappa b (RANK) is critical to bone turnover. Pre-clinical studies have shown that the ligand to RANK (RANKL) can induce metastases of RANK-expressed tumor cells, and that treatment with a RANKL inhibitor can reduce BC metastases. Our previous study suggests that higher RANK expression in tumor at the time of diagnosis correlates with worse recurrent free survival (RFS). Denosumab...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Li, J., Rugo, H. Tags: Ongoing Trials 2 - Targeted Agents Source Type: research
Prospective neo-adjuvant registry trial linking MammaPrint, subtyping and treatment response: Neo-adjuvant Breast Registry - Symphony Trial (NBRST)
Background: The FDA-approved MammaPrint 70 gene profile is performed on a diagnostic multi-gene array. This platform enables additional gene expression profiles to be analyzed simultaneously on one tumor specimen. One such gene expression profile is BluePrint, an 80 gene molecular subtyping profile that discriminates between three distinctive subtypes; Basal-type, Luminal-type, and HER2-type. By combining MammaPrint and BluePrint, patients can be stratified into the following subgroups: Luminal-type/MammaPrint Low Risk; Luminal-type/MammaPrint High Risk; HER2-type and Basal-type. Marked differences are observed in response...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Whitworth, P., Gittleman, M., Akbari, S., Nguyen, B., Baron, P., Rotkiss, M., Beatty, J., Gibson, J., Stork-Sloots, L., de Snoo, F., Beitsch, P. Tags: Ongoing Trials 3 - Response Prediction Source Type: research
Is OSNA mRNA copy number in sentinel lymph node biopsy predictive of further disease in the axilla?
Conclusion: OSNA CK19 mRNA copy number does not correlate with the cALND metastatic burden. Therefore, raising the copy number threshold may be too simplistic as a method to better select patients with high probability of a positive cALND. A predictive model will be derived based on multivariate analysis of the larger patient population (>400 patients) that will have undergone SLNB with OSNA by the time of SABCS.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-01-11. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Rusby, J., Agabiti, E., Waheed, S., Barry, P., Roche, N., Allum, W., Gui, G., MacNeill, F., Christaki, G., Osin, P., Nerurkar, A. Tags: Poster Session 1 - Detection/Diagnosis: Axillary Staging and Sentinel Nodes Source Type: research
Clinicopathlogic Analysis of Invasive Breast Carcinoma with Micropapillary Component
Conclusion: Our data showed very high rate of LN metastasis in patients with micropapillary component, and this tendency still exists in cases with only focal micropapillary pattern. High positivity of SLNB was observed in these groups, and our data suggests that the findings of micropapillary component in CNB specimen could be used as a predictor of SLN metastasis.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-01-20. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Yamanaka, T., Suganuma, N., Yamanaka, A., Kojima, I., Nishiyama, S., Mukaibashi, T., Nakayama, H., Matsuura, H., Matsuzu, K., Chiba, A., Inaba, M., Rino, Y., Yoshida, A., Shimizu, S., Masuda, M. Tags: Poster Session 1 - Detection/Diagnosis: Axillary Staging and Sentinel Nodes Source Type: research
The utility of axillary ultrasound and sentinel lymph node biopsy in the management of metaplastic breast carcinoma
Conclusions: For clinically node-negative MBC patients, our contemporary data series suggests the incidence of occult LN metastasis is sufficiently high to warrant LN staging especially for patients with intermediate and high-grade tumors. This can be accomplished in a minimally invasive fashion with reasonable accuracy (~97%) with axillary US, FNAB of sonographically suspicious LNs, and SLNB for patients with negative axillary US or FNAB. Axillary LND should be performed for patients with clinically and/or FNAB-positive LN for enhanced disease control.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-01-22...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Hieken, T., Fazzio, R., Reynolds, C., Jones, K., Ghosh, K., Glazebrook, K. Tags: Poster Session 1 - Detection/Diagnosis: Axillary Staging and Sentinel Nodes Source Type: research
Sentinel lymph node biopsy in breast cancer: The approach in day surgery under local anaesthesia for quality-of-life and significant cost reduction
This study was approved by an ethics committee, was discussed with all patients and informed consent was obtained.Purpose of the study is to investigate the approach in DS under LA for quality of life and significant cost reduction.Results: Six patients underwent pre-operative lymphoscintigraphy the radiotracer did not show any sentinel lymph node (SLN), in five cases we performed axillary dissection (AD). In one case of young patient who had previously been treated with chemotherapy for non-Hodgkin's lymphoma, negative positron emission tomography (PET), we performed quadrantectomy without AD. In three cases the axilla wa...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Ricci, F., Capuano, L., Saralli, E., Di Legge, P., Violante, A., Polistena, A., Scala, T., Pacchiarotti, A., Cannas, P., Cianni, R., Fanelli, G., Bellardini, P., De Masi, C. Tags: Poster Session 1 - Detection/Diagnosis: Axillary Staging and Sentinel Nodes Source Type: research
Conclusions: The use of a larger gauge core biopsy needle (e.g. 9-gauge) may yield superior tissue sampling and should likely be considered as the standard of care in the evaluation of image-detected breast abnormalities. In addition, biopsy results should not be considered definitively non-malignant when a high-risk lesion is identified. While there may be a trend towards not excising some of these high-risk lesions, we believe that a core biopsy demonstrating FEA still warrants surgical excision.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-02-01. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Tags: Poster Session 1 - Detection/Diagnosis: Biopsy Techniques Source Type: research
Conclusions: Our results show the low level of discordance for ER and HER2 between the primary and metastatic tumor. But re-biopsy should be considered in the patients with long TTR, since it is likely to impact treatment choice. Further study is needed to determine the value of re-biopsy.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-02-02. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Tags: Poster Session 1 - Detection/Diagnosis: Biopsy Techniques Source Type: research
Effect of biospecimen variables on proteomic biomarker assessment in breast cancer
Conclusions: There is remarkable homogeneity in expression of biomarkers within a tumor. However, proteomic markers are differentially expressed by biospecimen type and other preanalytic variables. PI3K pathway activation is greater in CNB compared to surgical samples.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-07-06. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Meric-Bernstam, F., Akcakanat, A., Chen, H., Sahin, A., Tarco, E., Carkaci, S., Adrada, B., Singh, G., Anh-Do, K., Garces, Z., Mittendorf, E., Babiera, G., Wagner, J., Bedrosian, I., Krishnamurthy, S., Symmans, W., Gonzalez-Angulo, A., Mills, G. Tags: Poster Session 1 - Prognostic and Predictive Factors: Biomarkers - Methods Source Type: research
Inflammatory gene expression variations in the interval between core needle biopsy and excisional biopsy in early breast cancer
Conclusions: In this study we found significant gene expression variations between CNBs and EBs in 9% of the genes tested, without any therapeutic intervention. Our findings suggest that when conducting a "Window of Opportunity" clinical study to evaluate for biomarkers of response or resistance, changes in expression of inflammatory genes cannot be attributed to treatment and a control arm should be considered.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-07-07. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Jeselsohn, R., Regan, M., Werner, L., Fatima, A., He, H., Brown, M., Iglehart, J., Richardson, A., Come, S. Tags: Poster Session 1 - Prognostic and Predictive Factors: Biomarkers - Methods Source Type: research
Down-regulation of trefoil protein 1(TFF1) in normal breast tissue of postmenopausal women at increased risk for breast cancer on exemestane
Discussion: Assessing tissue biomarkers with repeat core needle biopsies in a phase II prevention trial in high risk women is feasible. Since prevention agents are not universally protective, determining biomarkers of effect may allow tailored therapy. TFF1 is a biologically plausible biomarker of AI activity that was down-regulated in 77% of breast tissue following exemestane therapy. This is the first study to evaluate this tissue marker in the prevention setting. Further study is needed to correlate with other biomarkers of interest, e.g. change in mammographic density, serum hormone levels and clinical outcomes.Citatio...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Gatti-Mays, M., Kallakury, B., Makariou, E., Venzon, D., Permaul, E., Isaacs, C., Cohen, P., Warren, R., Gallagher, A., Eng-Wong, J. Tags: Poster Session 1 - Epidemiology, Risk, and Prevention: Prevention - Clinical Trials Source Type: research
Immunohistochemical classification of intrinsic subtypes as a predictive biomarker of pathological compelete response in breast cancer patients treated with preoperative chemotherapy.
Conclusion: This study indicated that immunohistochemical classification of intrinsic subtype might be a useful predictive biomarker of pCR in breast cancer patients treated with preoperative chemotherapy.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-14-09. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Nagayama, A., Jinno, H., Takahashi, M., Hayashida, T., Hirose, S., Kitagawa, Y. Tags: Poster Session 1 - Treatment: Neoadjuvant Chemotherapy Source Type: research
Determination of HER2 amplification by dual-color in situ hybridization before and after neoadjuvant chemotherapy
Conclusion: DISH revealed a stable HER2 status in pretreatment breast tumors and in residual tumors. However, we found a discrepancy in the HER2 status between the immunohistochemical analysis and DISH.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-05-08. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Niikura, N., Kumaki, N., Iwamoto, T., Tsuda, B., Okamura, T., Yuki, S., Suzuki, Y., Tokuda, Y. Tags: Poster Session 2 - Tumor Cell and Molecular Biology: Biomarkers Source Type: research
Continuous association of a 200-gene prognostic risk score with probability of neoadjuvant chemotherapy response and translation from fresh frozen to FFPE tissue for clinical use.
BreastPRS is a suite of complimentary gene signatures that resolves several of the significant limitations of current gene expression signatures in breast cancer. Notably, BreastPRS can accurately provide prognosis prediction, histological grade resolution and molecular subtyping of invasive breast cancer. The 200-gene prognostic component was previously validated in an independent retrospective series of 1,016 previously published fresh-frozen breast cancers and has now been applied to data from over 6,000 patients.In part one of this study, a meta-analysis of 890 previously published neoadjuvant treated breast cancer pat...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: van Laar, R., DiPaola, J., Carbaugh, H., Murphy, T., DiRamio, A., Flinchum, R., Brown, N., Albino, T. Tags: Poster Session 2 - Prognostic and Predictive Factors: Prognostic Factors - Clinical Source Type: research
Expression of lipid metabolism genes in contralateral unaffected breast associated with estrogen receptor status of breast cancer
Conclusion: Differential expression of lipid metabolism genes my be involved in the risk for subtypes of breast cancer, which might be potential biomarkers of ER specific breast cancer risk.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-10-30. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Wang, J., Scholtens, D., Holko, M., Ivancic, D., Lee, O., Hu, H., Chatterton, R., Khan, S. Tags: Poster Session 2 - Prognostic and Predictive Factors: Prognostic Factors - Clinical Source Type: research
Development and validation of ClinicoMolecular Triad Classification (CMTC), a platform for breast cancer (BC) prognostic and predictive gene signature portfolios.
This study aimed to validate the CMTC classification using an independent BC cohort.Study design/ results: RNA from fine needle aspirates were collected in a prospective BC cohort (n = 340) between 2008 and 2010 at Princess Margaret Hospital and Mount Sinai Hospital, Toronto, we included all newly diagnosed BC patients going for surgery who consented to join the study. DNA microarray analyses were carried out using genome-wide Illumina Human Ref-8 version 3 Beadarrays, which contained >24K oligonucleotide probes. After excluding tumors with low RNA yield (n = 8, success rate 97%), non-invasive cancers (n = 27), insuffic...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Leong, W., Wang, D.-Y., Done, S., McCready, D. Tags: Poster Session 2 - Prognostic and Predictive Factors: Prognostic Factors - Clinical Source Type: research
Prognostic factors uPA/PAI-1: measurement in core needle biopsies
Conclusion: Most important, low uPA/PAI-1 results in core-needle biopsies predict low results in the surgical specimen. In some cases, core-needle biopsies and surgical specimen show discordant data. These cases do not correlate with any clinical or pathological factors such as time between needling and surgery, grading, tumor size or hospital. We assume that these discordances are caused by pre-surgical manipulations, which change expression patterns in the remaining tissue as it is reported also from multi-gene tests.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-10-38. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Vetter, M., Landstorfer, B., Lantzsch, T., Buchmann, J., Grosse, R., Ruschke, K., Holzhausen, H.-J., Thomssen, C., Kantelhardt, E.-J. Tags: Poster Session 2 - Prognostic and Predictive Factors: Prognostic Factors - Clinical Source Type: research
The Role of Mammographic Calcification in the Neo-adjuvant Therapy of Breast Cancer Imaging Evaluation
Conclusion: Patients with malignant calcification are more likely to have ER positive and Her2 positive diseases. MG should be considered the standard prior to the start of therapy, the distribution and range of the calcification may predict pCR rate. Calcification appearance does not change significantly after neo-adjuvant therapy, therefore MG is not an appropriate method for efficacy evaluation. But MG before surgery is still useful to identify the extent of surgery, especially in breast conserve therapy.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-01-05. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Li, J., Chen, C., Di, G., Wu, J., Lu, J., Shao, Z.-M. Tags: Poster Session 3 - Detection/Diagnosis: Breast Imaging - Mammography Source Type: research
Expression of hormone-responsive genes in benign breast tissue varies with menstrual cycle phase and menopausal status
Conclusion: The expression levels of TNFSF11, DIO2 and MYBPC1 vary with MCP and MPS. These hormone-responsive genes are candidate MCP classifiers which could be applied to archived breast samples to assess whether biomarkers of breast cancer risk are stable across the menstrual cycle, since MCP and MPS variation is likely an important source of biological noise in studies of archived breast biopsy material.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-04-08. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Hu, H., Wang, J., Lee, O., Shidfar, A., Iyer, S., Ivancic, D., Chatterton, R., Stearns, V., Sukumar, S., Khan, S. Tags: Poster Session 3 - Tumor Cell and Molecular Biology: Molecular Profiles Source Type: research
Predictive biomarker of pathologic complete response to neoadjuvant chemotherapy in triple negative breast cancer
Neoadjuvant chemotherapy has been considered valuable beyond its role in facilitating conservative surgery and improving prognosis associated with pathologic complete response. Predictive factors of response would help to assess the expected individual benefit of this treatment. Bcl-2 and p53 have been mostly investigated predictive biomarker for the efficacy of chemotherapy in breast cancer, however, studies documenting predictive significance of biomarkers in triple negative breast cancer(TNBC) are limited by low n values of patients. Furthermore, studies did not provide consistent result to conclude about predictive val...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Kim, T., Han, W., Moon, H.-G., Noh, D.-Y. Tags: Poster Session 3 - Prognostic and Predictive Factors: Response Predictions - Biomarkers and Other Factors Source Type: research
Ki-67 mRNA as a predictor for response to neoadjuvant chemotherapy in primary breast cancer
Conclusion: The Single-Sample-Predictor based on assessment of only five mRNA Markers (ESR1, PGR, HER2, Ki-67 and RACGAP1) reliably stratified into molecular subtypes by using either fixed or fresh pretreatment core needle biopsies. The mRNA based assessment enables objective and highly reproducible subtyping for clinical routine diagnostics.1) Goldhirsch et al., Annals of Oncology 20112) Perou et al., Nature 20003) Sotiriou&Pusztai, NEJM 20094) Schneeweiss et al, Ann Oncol 2011Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-06-19. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Aigner, J., Schneeweiss, A., Marme, F., Eidt, S., Altevogt, P., Sinn, P., Wirtz, R. Tags: Poster Session 3 - Prognostic and Predictive Factors: Response Predictions - Biomarkers and Other Factors Source Type: research
Mechanisms behind trastuzumab resistance as neoadjuvant therapy in HER2-positive operable breast cancer
Conclusions: These data indicate that aberrant downstream signaling caused by loss of PTEN and/or PIK3CA mutation, alternative signaling from IGF-1R and masking with MUC4 were not important mechanisms of resistance to trastuzumab.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-06-22. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Jinno, H., Sato, T., Hayashida, T., Takahashi, M., Hirose, S., Kitagawa, Y. Tags: Poster Session 3 - Prognostic and Predictive Factors: Response Predictions - Biomarkers and Other Factors Source Type: research
Compliance with Recommended Follow-Up after MRI-guided Core Needle Biopsy of Suspicious Breast Lesions: A Retrospective Study
Conclusion: Compliance with follow-up MRI recommendation after core needle biopsy is low. Three characteristics were found to be associated with noncompliance with follow-up imaging: referral from non-affiliated physician, screening MRI, and a focus lesion. Moreover, patients who do not comply with recommended MRI follow-up are more likely to have follow-up mammography. Follow-up imaging among compliant patients found high-risk lesions and malignancy. Facilities performing MRI-guided core biopsies should therefore be aware of a high risk of noncompliance with follow-up.Citation Information: Cancer Res 2012;72(24 Suppl):Abs...
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Thompson, M., Lipson, J., Daniel, B., Harrigal, C., Mullarkey, P., Ikeda, D. Tags: Poster Session 4 - Detection/Diagnosis: Breast Imaging - MRI Source Type: research