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The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study demonstrates that bindarit is effective in reducing neointima formation in both non-hyperlipidaemic and hyperlipidaemic animal models of vascular injury by a direct effect on VSMC proliferation and migration and by reducing neointimal macrophage content. All of these data were associated with the inhibition of MCP-1 production. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Grassia, G., Maddaluno, M., Guglielmotti, A., Mangano, G., Biondi, G., Maffia, P., Ialenti, A. Tags: ORIGINAL ARTICLES Source Type: journals

Thirty-Day Outcome Following Carotid Artery Stenting: A 10-Year Experience from a Single CenterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, CAS can be performed safely and effectively, with acceptable mortality, stroke/death, and cardiovascular complication rates. Although technological advances (stent design, cerebral protection devices), perioperative pharmacological management, and increasing experience are all clinically significant factors influencing the short-term results, none appeared to be statistically significant in this patient sample. Content Type Journal ArticleCategory Clinical InvestigationDOI 10.1007/s00270-009-9746-9Authors Christos D. Karkos, Aristotle University of Thessaloniki Fifth Department of Surgery, Medical Sc...
Source: CardioVascular and Interventional Radiology - November 12, 2009 Category: Radiology Tags: CardioVascular and Interventional Radiology Source Type: journals

Systematic Review of Randomized Controlled Trials of Patch Angioplasty Versus Primary Closure During Carotid Endarterectomy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19910540 [PubMed - as supplied by publisher] (Source: Stroke)
Source: Stroke - November 12, 2009 Category: Neurology Authors: Rerkasem K, Rothwell PM Tags: Stroke Source Type: journals

MMP-2 and MMP-9 Alteration in Response to Collaring in Rabbits: The Effects of Endothelin Receptor AntagonismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigate the possible role of gelatinases and the effect of a nonselective ETA/ETB receptor antagonist, TAK-044 (5 mg/kg body weight/day, subcutaneously [sc]), on these enzymes. Our results demonstrated that both MMP-2 and MMP-9 activities increased in response to collaring in placebo group, while treatment with TAK-044 significantly suppressed both gelatinase activities and proMMP-2 levels, and inhibited intimal thickening in collared arteries. These results suggest that either enhanced MMP expression or endothelin receptor antagonism may be involved in the formation of intimal thickening in this mode...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - November 11, 2009 Category: Cardiology Authors: Reel, B., Oktay, G., Ozkal, S., Islekel, H., Ozer, E., Ozsarlak-Sozer, G., Cavdar, Z., Akhisaroglu, S. T., Kerry, Z. Tags: Articles Source Type: journals

Systematic Review of the Perioperative Risks of Stroke or Death After Carotid Angioplasty and Stenting.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Risks of CAS vary substantially across studies. Risks are overall higher than those of CEA in symptomatic patients. Some factors are likely to help select good candidates for CAS. PMID: 19892997 [PubMed - as supplied by publisher] (Source: Stroke)
Source: Stroke - November 5, 2009 Category: Neurology Authors: Touzé E, Trinquart L, Chatellier G, Mas JL Tags: Stroke Source Type: journals

Carotid angioplasty and stenting: will it ever replace endarterectomy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: International Journal of Stroke)
Source: International Journal of Stroke - November 4, 2009 Category: Neurology Authors: B. Chambers Tags: Leading opinions Source Type: journals

Src-dependent STAT-3-mediated Expression of Monocyte Chemoattractant Protein-1 Is Required for 15(S)-Hydroxyeicosatetraenoic Acid-induced Vascular Smooth Muscle Cell Migration [Mechanisms Of Signal Transduction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To understand the role of human 15-lipoxygenase 1 (15-LOX1) in vascular wall remodeling, we have studied the effect of the major 15-LOX1 metabolite of arachidonic acid, 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), on vascular smooth muscle cell (VSMC) migration both in vitro and in vivo. Among 5(S)-HETE, 12(S)-HETE, and 15(S)-HETE, 15(S)-HETE potentially stimulated more vascular smooth muscle cell (VSMC) migration. In addition, 15(S)-HETE-induced VSMC migration was dependent on Src-mediated activation of signal transducer and activator of transcription-3 (STAT-3). 15(S)-HETE also induced monocyte chemoattractant protei...
Source: Journal of Biological Chemistry - October 30, 2009 Category: Chemistry Authors: Potula, H. S. K., Wang, D., Van Quyen, D., Singh, N. K., Kundumani-Sridharan, V., Karpurapu, M., Park, E. A., Glasgow, W. C., Rao, G. N. Tags: Mechanisms Of Signal Transduction Source Type: journals

Carotid Endarterectomy versus Carotid Angioplasty Cui Bono.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: At the present time, CEA remains the intervention of choice in the management of carotid bifurcation disease. PMID: 19879167 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - October 28, 2009 Category: Surgery Authors: Moore WS Tags: Eur J Vasc Endovasc Surg Source Type: journals

Arterial gene transfer of the TGF-{beta} signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGFEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Medial gene transfer of Smad3 promotes adaptive remodelling by indirectly influencing the behaviour of adventitial fibroblasts. This arterial cell–cell communication is likely to be mediated by Smad3-dependent production of CTGF. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Kundi, R., Hollenbeck, S. T., Yamanouchi, D., Herman, B. C., Edlin, R., Ryer, E. J., Wang, C., Tsai, S., Liu, B., Kent, K. C. Tags: ORIGINAL ARTICLES Source Type: journals

Carotid angioplasty and stenting in anatomically high-risk patients: Safe and durable except for radiation-induced stenosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: CAS is as technically feasible, safe, and durable in anatomically high-risk patients as in medically high-risk patients, with similar rates of periprocedural stroke and death and late restenosis. However, patients with radiation-induced stenosis appear to be at an increased risk for restenosis. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - September 28, 2009 Category: Surgery Authors: Susanna H. Shin, Christopher L. Stout, Albert I. Richardson, Richard J. DeMasi, Rasesh M. Shah, Jean M. Panneton Tags: From the Southern Association for Vascular Surgery Source Type: journals

Angioplasty and stenting of symptomatic and asymptomatic vertebral artery stenosis: to treat or not to treatEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Angioplasty and stenting appears to be technically feasible and safe in asymptomatic and symptomatic vertebral stenosis. More studies are needed in order to clarify its role in primary and secondary prevention of vertebrobasilar stroke. High risk anterior circulation lesions should be taken into account as a possible indication in patients with asymptomatic vertebral stenosis. (Source: European Journal of Neurology)
Source: European Journal of Neurology - September 16, 2009 Category: Neurology Authors: V. Parkhutik, A. Lago, JI. Tembl, F. Aparici, V. Vazquez, E. Mainar Source Type: journals

Immediate and 30-Day Clinical Outcome of Patients Treated with the TwinOne Cerebral Protection System: Multicenter Experience in 217 CasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this cerebral protection system is simple to use, allows a quick intervention and short occlusion time, and has a low rate of complications. Content Type Journal ArticleCategory Clinical InvestigationDOI 10.1007/s00270-009-9686-4Authors Jacques Theron, CHU Côte de Nacre Department of Neuroradiologie Avenue de la Côte de Nacre Caen 14000 FranceCarlo Venturi, Policlinico “Le Scotte,” Azienda Ospedaliera Senese Department of Neuroradiology Viale M. Bracci 1 53100 Siena ItalyJuergen Reul, Klinik für Neuroradiologie–KKH Siegen Weidenauer Strasse 76 57074 Siegen GermanyZoran Milosevic, University Cl...
Source: CardioVascular and Interventional Radiology - September 16, 2009 Category: Radiology Tags: CardioVascular and Interventional Radiology Source Type: journals

Percutaneous versus surgical revascularization for symptomatic carotid artery diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Stroke is the third leading cause of death worldwide and the number one disease associated with permanent disability. In 2006, the estimated total cost of stroke in the United States was a staggering $60 billion. Significant stenosis of the internal carotid artery is responsible for 10% to 20% of all strokes, and current recommendations suggest that patients with symptomatic carotid artery stenosis undergo revascularization for stroke prevention or risk reduction. Since the 1950s, carotid endarterectomy (CEA) has been the dominant modality of revascularization. However, carotid artery angioplasty, i...
Source: Current Cardiology Reports - September 16, 2009 Category: Cardiology Tags: Current Cardiology Reports Source Type: journals

Computed tomography angiography, perfusion computed tomography, and a drug-eluting stent for the treatment of in-stent restenosis of the middle cerebral artery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors report a case of in-stent restenosis (ISR) of the middle cerebral artery (MCA) following bare-metal stent (BMS) deployment and subsequent treatment using a drug-eluting stent (DES). This 65-year-old woman presented with frequent transient ischemic attacks. Initial studies revealed occlusion of the left internal carotid artery and severe stenosis of the right MCA with decreased cerebral perfusion in the bilateral MCA territories. Stent-assisted angioplasty of the right MCA was performed using a BMS, and satisfactory results were obtained with no complications. Six months after the procedure the patient prese...
Source: Journal of Neurosurgery - September 10, 2009 Category: Neurosurgery Authors: Kim SR, You SH, Yoon WK, Kim YW, Kim SD, Park IS, Baik MW Tags: J Neurosurg Source Type: journals

Clinical Trial Summary: Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CAVATAS was a randomized, prospective, multicenter, exploratory, clinical trial designed to compare endovascular treatment (percutaneous transluminal angioplasty and stenting) with conventional surgery in patients with severe carotid artery stenosis. (Source: Cardiosource)
Source: Cardiosource - September 8, 2009 Category: Cardiology Source Type: organizations

[Articles] Endovascular treatment with angioplasty or stenting versus endarterectomy in patients with carotid artery stenosis in the Carotid And Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endovascular treatment (angioplasty with or without stenting) is an alternative to carotid endarterectomy for carotid artery stenosis but there are scarce long-term efficacy data showing that it prevents stroke. We therefore report the long-term results of the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS). (Source: Lancet Neurology)
Source: Lancet Neurology - September 7, 2009 Category: Neurology Authors: Jörg Ederle, Leo H Bonati, Joanna Dobson, Roland L Featherstone, Peter A Gaines, Jonathan D Beard, Graham S Venables, Hugh S Markus, Andrew Clifton, Peter Sandercock, Martin M Brown, on behalf of the CAVATAS Investigators Tags: Articles Source Type: journals

[Articles] Long-term risk of carotid restenosis in patients randomly assigned to endovascular treatment or endarterectomy in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS), early recurrent carotid stenosis was more common in patients assigned to endovascular treatment than it was in patients assigned to endarterectomy (CEA), raising concerns about the long-term effectiveness of endovascular treatment. We aimed to investigate the long-term risks of restenosis in patients included in CAVATAS. (Source: Lancet Neurology)
Source: Lancet Neurology - September 7, 2009 Category: Neurology Authors: Leo H Bonati, Jörg Ederle, Dominick JH McCabe, Joanna Dobson, Roland L Featherstone, Peter A Gaines, Jonathan D Beard, Graham S Venables, Hugh S Markus, Andrew Clifton, Peter Sandercock, Martin M Brown, on behalf of the CAVATAS Investigators Tags: Articles Source Type: journals

Carotid surgery better long-term than angioplasty and stentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from CAVATAS are in, and they suggest that carotid endarterectomy provides superior long-term outcomes over endovascular treatment. (Source: theHeart.org)
Source: theHeart.org - September 4, 2009 Category: Cardiology Source Type: info

Carotid Surgery Better Long-Term Than Angioplasty and StentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from CAVATAS are in, and they suggest that carotid endarterectomy provides long-term outcomes superior to those of endovascular treatment. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 4, 2009 Category: Consumer Health News Tags: Neurology & Neurosurgery Source Type: news

Patients Who Have Material Causing Narrowing In Neck Artery Removed Rather Than Angioplasty Have Lower Chance Of Narrowing Recurring And StrokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two Articles published Online First and in the October edition of The Lancet Neurology provide long-term data that show that, for patients with a narrowing of the carotid artery supplying blood to brain (carotid stenosis), removal of the material causing the narrowing(endarterectomy [surgery]) could be a better option than balloon angioplasty with or without stenting (endovascular treatment [ET]). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 3, 2009 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

Lancet: Carotid surgery may best stenting in stroke preventionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two studies published Aug. 28 in Lancet Neurology provide long-term data showing that for patients with carotid stenosis, endarterectomy could be a better option than balloon angioplasty with or without stenting (endovascular treatment). Surgery reduces the risk of both short-term and long-term stroke, and reduces the risk of repeat stenosis—which itself reduces the risk of stroke. (Source: Cardiovascular Business News)
Source: Cardiovascular Business News - September 1, 2009 Category: Cardiology Tags: Latest News Source Type: news

Stent-assisted percutaneous angioplasty for extra-cranial carotid disease:experience at Singapore General Hospital.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: CAS is a technically feasible and a relatively safe alternative to endarterectomy to treat extracranial carotid stenosis, especially in patients who are inoperable or at high surgical risk. PMID: 19816633 [PubMed - in process] (Source: Annals of the Academy of Medicine, Singapore)
Source: Annals of the Academy of Medicine, Singapore - August 31, 2009 Category: Journals (General) Authors: Gogna A, Lath N, Chang HM, Tan BS, Wong MC, Koh TH, Lim ST, Htoo MM, Lim WE Tags: Ann Acad Med Singapore Source Type: journals

Surgery Better Than Angioplasty for Narrowed Neck ArteryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
British study finds a reduced risk of stroke afterwards Source: HealthDay Related MedlinePlus Topics: Angioplasty, Carotid Artery Disease, Stroke (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - August 31, 2009 Category: Consumer Health News Source Type: consumer

Long-Term Outcome Of Endovascular Treatment Versus Endarterectomy In Patients With Carotid Stenosis (CAVATAS Study)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with carotid stenosis, a narrowing of the carotid artery that supplies blood to the brain, could have a better treatment outcome by removing the material causing the narrowing with a surgery called endarterectomy. The other alternative is balloon angioplasty with or without the placing of a stent (small wire mesh tube in the artery) also known as endovascular treatment (ET). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 31, 2009 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

Restenosis More Common After Angioplasty Than SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although patients treated for carotid artery stenosis with endovascular treatment are significantly more likely to have restenosis than those treated with carotid endarterectomy, stroke risk for both groups is low, according to two papers from the Carotid And Vertebral Artery Transluminal Angioplasty Study published online Aug. 29 in The Lancet. (Source: Modern Medicine)
Source: Modern Medicine - August 30, 2009 Category: Journals (General) Source Type: info

Long-term Risks Lower for Surgical Treatment of Carotid Stenosis (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Carotid endarterectomy was more effective than balloon angioplasty at preventing restenosis and showed a trend toward reducing the risk of stroke, according to two studies reporting on a long-running, randomized trial of treatments for carotid stenosis. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - August 28, 2009 Category: Cardiology Source Type: news

Treatment of limb-shaking TIAs with external carotid artery stentingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case in which a patient with preexisting left internal carotid artery (ICA) occlusion developed limb-shaking TIAs secondary to severe stenosis of her left external carotid artery (ECA). After angioplasty and stenting of her left ECA, her symptoms resolved. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - August 27, 2009 Category: Neurosurgery Authors: L. Christine Turtzo, Philippe Gailloud, Rebecca F. Gottesman Tags: Case reports Source Type: journals

Predictors of clinically significant postprocedural hypotension after carotid endarterectomy and carotid angioplasty with stentingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Postprocedural hypotension occurs more commonly with CAS than CEA and is associated with increased postprocedural myocardial infarction and length of stay, and death. Nitrates and tobacco use predict a higher incidence of postprocedural hypotension. High-risk patients should be aggressively managed to prevent the increased morbidity and mortality due to postprocedural hypotension. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - August 26, 2009 Category: Surgery Authors: Brian D. Park, Thomas Divinagracia, Olga Madej, Caitlin McPhelimy, Bryan Piccirillo, Michael S. Dahn, Steven Ruby, James O. Menzoian Tags: From the Society for Clinical Vascular Surgery Source Type: journals

Mild glucose intolerance in pregnancy and risk of cardiovascular disease: a population-based cohort study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BACKGROUND: Pregnant women commonly receive screening for gestational diabetes mellitus by use of a 50 g glucose challenge test, followed by a diagnostic oral glucose tolerance test for those whose glucose challenge test result is abnormal. Although women with gestational diabetes have an increased risk of cardiovascular disease, it is not known whether mild glucose intolerance during pregnancy is also associated with cardiovascular disease. Thus, we sought to determine whether pregnant women with an abnormal glucose challenge test result but without gestational diabetes have an increased risk of cardiovascular disease...
Source: cmaj - August 23, 2009 Category: Journals (General) Authors: Retnakaran R, Shah BR Tags: CMAJ Source Type: journals

Medical (Nonsurgical) Intervention Alone Is Now Best for Prevention of Stroke Associated With Asymptomatic Severe Carotid Stenosis. Results of a Systematic Review and Analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, current vascular disease medical intervention alone is now best for stroke prevention associated with asymptomatic severe carotid stenosis given this new evidence, other cardiovascular benefits, and because high-risk patients who benefit from additional carotid surgery or angioplasty/stenting cannot be identified. PMID: 19696421 [PubMed - as supplied by publisher] (Source: Stroke)
Source: Stroke - August 19, 2009 Category: Neurology Authors: Abbott AL Tags: Stroke Source Type: journals

Magnetic Tagging Increases Delivery of Circulating Progenitors in Vascular InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Using an externally applied magnetic device, we have been able to enhance EPC localization at a site of common carotid artery injury. This technology could be more widely adapted to localize cells in other organs and may provide a useful tool for the systemic injection of cell therapies. (Source: Journal of the American College of Cardiology: Cardiovascular Interventions)
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - August 16, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Kyrtatos, P. G., Lehtolainen, P., Junemann-Ramirez, M., Garcia-Prieto, A., Price, A. N., Martin, J. F., Gadian, D. G., Pankhurst, Q. A., Lythgoe, M. F. Tags: Clinical Research Source Type: journals

Stent-protected angioplasty in asymptomatic carotid artery stenosis vs. endarterectomy: SPACE2 – a three-arm randomised-controlled clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Moderate to severe ([ge]70%) asymptomatic stenosis of the extracranial carotid artery leads to an increased rate of stroke of approximately 11% in 5 years. Patients with asymptomatic carotid stenosis, however, are also at a higher risk of nonstroke vascular events. The estimated annual risks of such events in patients with asymptomatic stenosis are 7% for a coronary ischaemic event and 4[ndash]7% for overall mortality. The superiority of carotid endarterectomy compared with medical treatment in symptomatic carotid disease is established, provided that the surgical procedure can be performed with a perioperative morbidity a...
Source: International Journal of Stroke - August 11, 2009 Category: Neurology Authors: T. Reiff, R. Stingele, H. H. Eckstein, G. Fraedrich, O. Jansen, H. Mudra, U. Mansmann, W. Hacke, P. Ringleb Tags: Clinical trial protocols Source Type: journals

Neurofibromatosis type 1 and multiple traumatic cervical arterial injuries : a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Patients with medical history of neurofibromatosis type I, are at risk to develop blunt cervical vascular injury. This association has to be known by emergency and intensivist physicians to optimize screening of cerebrovascular injuries and treat early such devastating lesions. (Source: Cases Journal)
Source: Cases Journal - August 6, 2009 Category: Journals (General) Source Type: journals

Change in Cerebral Perfusion after Carotid Angioplasty with Stenting Is Related to Cerebral Vasoreactivity: A Study Using Dynamic Susceptibility-Weighted Contrast-Enhanced MR Imaging and Functional MR Imaging with a Breath-Holding Paradigm [FUNCTIONAL]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: fMRI could be a reproducible tool in evaluating CVR. After CAS, early CBF changes on the lesion side are more prominent in patients with impaired CVR. Baseline CVR might predict early CBF increase after CAS. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - August 6, 2009 Category: Radiology Authors: Chang, T.-Y., Liu, H.-L., Lee, T.-H., Kuan, W.-C., Chang, C.-H., Wu, H.-C., Wu, T.-C., Chang, Y.-J. Tags: FUNCTIONAL Source Type: journals

Placement of Covered Stents for the Treatment of Direct Carotid Cavernous Fistulas [INTERVENTIONAL]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although a larger sample and expanded follow-up are needed, our series shows that covered stents can be used in the treatment of DCCFs with symptomatic relief. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - August 6, 2009 Category: Radiology Authors: Wang, C., Xie, X., You, C., Zhang, C., Cheng, M., He, M., Sun, H., Mao, B. Tags: INTERVENTIONAL Source Type: journals

Acute Cerebrovascular Accident Presenting as Possible Carotid Artery Dissection After Motor Vehicle Crash: Report of a CaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a patient who had a potentially confusing presentation, with features consistent with an acute cerebrovascular accident, and also consistent with a traumatic arterial dissection. Case: A 43-year-old diabetic, hypertensive man arrived at our Emergency Department after a single-vehicle, frontal-impact motor vehicle crash. Emergency Medical Services first responders found the man seated in his crashed van, stating that he sneezed and then crashed into a tree at approximately 60 kilometers per hour, after veering leftward off the road. The patient denied any difficulty controlling the car before the sneeze ...
Source: The Journal of Emergency Medicine - July 31, 2009 Category: Emergency Medicine Authors: Ruben Font, Gary Gaddis Tags: Humanities and Medicine Source Type: journals

Outcome of carotid endarterectomy under local anaesthesia with respect to the patients' risk profile.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: With the routine use of LA, CEA was not associated with worse outcome in high-risk patients. Considering the data reported in the literature, it does not appear justified to refer high-risk patients principally to carotid angioplasty and stenting (CAS) when LA can be chosen to perform CEA. PMID: 19736633 [PubMed - in process] (Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases)
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - July 31, 2009 Category: Surgery Authors: Aleksic M, Luebke T, Brunkwall J Tags: Vasa Source Type: journals

Proposed duplex velocity criteria for carotid restenosis following carotid endarterectomy with patch closureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study includes 200 CEAs randomized into 100 with polytetrafluoroethylene (PTFE) ACUSEAL patch and 100 with Hemashield Finesse patch. All patients underwent immediate postoperative duplex ultrasounds, which were repeated at 1 month and every 6 months thereafter. Patients with a peak systolic velocity (PSV) of the internal carotid artery ([ICA], just distal to the patch) of ≥130 c/s underwent computed tomography angiogram (CTA). PSVs, end diastolic velocities (EDV), and internal carotid artery/common carotid artery (ICA/CCA) ratios were correlated to completion arteriograms/CTAs. Receiver operator characteristic curve...
Source: Journal of Vascular Surgery - July 28, 2009 Category: Surgery Authors: Ali F. AbuRahma, Patrick Stone, Samuel Deem, L. Scott Dean, Tammi Keiffer, Emily Deem Tags: From the Southern Association for Vascular Surgery Source Type: journals

Carotid angioplasty and stentingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
— Overview covers definition, risks and results of this stroke treatment. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - July 25, 2009 Category: Consumer Health News Source Type: news

Video: Carotid angioplasty and stentingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Carotid angioplasty and stenting — See how this stroke treatment is done. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - July 24, 2009 Category: Consumer Health News Source Type: news

Combined carotid stenting and urgent coronary artery surgery in unstable angina patients with severe carotid stenosis [Institutional report - Coronary]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report in-hospital and 30-day outcomes of 23 consecutive patients admitted with unstable angina, who underwent carotid angioplasty and stenting (CAS) immediately prior to urgent coronary artery surgery, from October 2007 to October 2008. Aspirin and unfractioned heparin were administrated during carotid stenting and clopidogrel was only started after cardiac surgery. All patients remained event-free during and immediately after the carotid stenting procedure. One patient died due to sepsis 22 days after cardiac surgery. There was neither stroke nor myocardial infarction at follow-up. No patient needed a cardiac or ...
Source: Interactive CardioVascular and Thoracic Surgery - July 22, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Guerra, M., Mota, J. C., Veloso, M., Gama, V., Vouga, L. Tags: Institutional report - Coronary Source Type: journals

Optimal cut-off criteria for duplex ultrasound for the diagnosis of restenosis in stented carotid arteries: review and protocol for a diagnostic studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DiscussionTo address the deficiencies of the existing studies, we propose a prospective cohort study nested within the International Carotid Stenting Study (ICSS), an international multi-centre trial in which over 1,700 patients have been randomised between stenting and CEA. In this cohort we will enrol a minimum of 300 patients treated with a stent. All patients undergo regular DUS examination at the yearly follow-up visit according to the ICSS protocol. To avoid verification bias, an additional computed tomography angiography (CTA) will be performed as a reference test in all consecutive patients, regardless the degree o...
Source: BMC Neurology - July 21, 2009 Category: Neurology Authors: Paul NederkoornMartin Brown Source Type: journals

Carotid endarterectomy (CEA), carotid artery stenting (CAS) and stroke recovery which of them are better for recovery of brain functions or prevention of cognitive decline?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction. For many years CEA has been considered the gold standard concerning surgical approach for symptomatic and asymptomatic ICA stenosis. Despite this, there still remains some risk of CI or death and complications resulting from surgery. In recent years, there has been increasing enthusiasm for carotid angioplasty and CAS as an alternative or complementary method to CEA for these situations. It has some advantages, and showed promising results but with a higher complication rate compared to CEA. At present, there are no data concerning the relationship between these procedures and recovery of brain functions. (So...
Source: Journal of the Neurological Sciences - July 17, 2009 Category: Neurology Authors: D. Bartko, I. Combor, O. Pechanova, M. Boselova Tags: Abstracts Source Type: journals

Carotid angioplasty and stenting: Treatment of postcarotid endarterectomy restenosis is at least as safe as primary stenosis treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CAS for restenosis after CEA has a complication rate lower than primary CAS. The time interval between CEA and CAS did not influence micro embolic load. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - July 5, 2009 Category: Surgery Authors: Jan Albert Vos, Gert Jan de Borst, Tim T. Overtoom, Jean Paul P. de Vries, Eric D. van de Pavoordt, Pieter Zanen, Rob G. Ackerstaff, Antonius carotid Endarterectomy, angioplasty, and Stenting Study Group Tags: From the Society for Vascular Surgery Source Type: journals

Patches for carotid artery endarterectomy: Current materials and prospectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patch angioplasty is commonly performed after carotid endarterectomy. Randomized prospective trials and meta-analyses have documented improved rates of perioperative and long-term stroke prevention as well as reduced rates of restenosis for patches compared with primary closure of the arteriotomy. Although use of vein patches is considered to be the gold standard for patch closure, newer generations of synthetic and biologic materials rival outcomes associated with vein patches. Future bioengineered patches are likely to optimize patch performance, both by achieving minimal stroke risk and long-term rates of restenosis as ...
Source: Journal of Vascular Surgery - June 29, 2009 Category: Surgery Authors: Akihito Muto, Toshiya Nishibe, Herbert Dardik, Alan Dardik Tags: Review article Source Type: journals

Role of endothelial progenitor cell mobilization after percutaneous angioplasty procedure.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Circulating endothelial progenitor cells (EPCs) are bone marrow-derived cells, contributing to endothelial cell regeneration of injured vessels as well as neovascularization of ischemic lesions. EPC levels and function are inversely correlated with cardiovascular risk factors, can predict the occurrence of adverse events and atherosclerotic disease progression. Ischemia and inflammation are the primary triggers for EPC mobilization and homing, however, vascular trauma, as it occurs during surgical procedures, has been demonstrated to stimulate EPC mobilization even in absence of tissue ischemia. The effect of angioplas...
Source: Current Pharmaceutical Design - June 27, 2009 Category: Drugs & Pharmacology Authors: Barsotti MC, Di Stefano R, Spontoni P, Chimenti D, Balbarini A Tags: Curr Pharm Des Source Type: journals

Utility of Intravascular Ultrasound Examination during Carotid StentingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: IVUS examination provides complementary information to that obtained using conventional diagnostic procedures. It may be useful for characterizing the composition and measurement of the target lesion, choosing the type and size of the stent, and evaluating the results after the procedure. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - June 23, 2009 Category: Surgery Authors: M. Mellado Joan, B. Gómez Moya, F. Pañella Agustí, R. García Vidal, Y. Abril Arjona, M.P. Fariñas Alija, V. Martín Paredero Tags: Clinical Research Source Type: journals

Texas Governor Signs Landmark Early Heart Disease Detection Screening LegislationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Today Governor Rick Perry of Texas signed the nation's first preventive cardiovascular screening bill for early detection of coronary artery disease. The legislation, which will take effect on September 1, requires Texas insurers to pay up to $200 for a either a non-contrast computed tomography (CT) scan measuring coronary artery calcification, commonly known as a Calcium scoring exam, or ultrasonography for measuring carotid intima-media thickness and plaque. (Source: News from Angioplasty.Org)
Source: News from Angioplasty.Org - June 23, 2009 Category: Cardiology Source Type: news

Refractory In-stent Restenosis Following Carotid Artery Stenting: A Case Report and Review of Operative ManagementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In-stent restenosis following carotid artery stenting is a challenging problem that vascular surgeons will likely encounter with increasing frequency. The following describes a patient who developed progressive in-stent restenosis 3 years after carotid artery stenting, which was treated with operative therapy after failed balloon angioplasty. A review of the literature describing surgical approaches to the treatment of in-stent restenosis was also performed. (Source: Vascular and Endovascular Surgery)
Source: Vascular and Endovascular Surgery - June 21, 2009 Category: Surgery Authors: King, B. N., Scher, L. A., Lipsitz, E. C. Tags: Article Source Type: journals

Endovascular Treatment of Carotid Stenosis Associated with Incidental Intracranial AneurysmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a 73-year-old woman with a history of arterial hypertension and diabetes who had a severe symptomatic ICA stenosis (>90%) and an incidental ipsilateral cerebral aneurysm. The carotid stenosis was treated with angioplasty and stenting using a distal cerebral protection system. The patient was anticoagulated and maintained on antiplatelet therapy according to a standard protocol. Microcoil embolization of the aneurysm was performed 5 months after an intracranial stent was implanted. No growth has been observed in the aneurysm of the arterial lumen since the carotid intervention. There were no complicatio...
Source: Annals of Vascular Surgery - June 18, 2009 Category: Surgery Authors: Gaudencio Espinosa, Lukasz Dzieciuchowicz, Lukasz Grochowicz Tags: Basic Science Research Source Type: journals