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Effect of non-nutritive sweeteners on insulin regulation, glycemic response, appetite and weight management: a systematic review
This study was, thus, designed with the objective of examining the usefulness of NNSs in human population, especially with respect to insulin regulation, glycemic control and weight management. Well-designed randomized control trials which control for confounding variables are needed to generate high quality evidence.
Source: Nutrition and Food Science - September 23, 2023 Category: Nutrition Authors: Pulkit Mathur Anjani Bakshi Source Type: research

Sequencing Quadruple Therapy for Heart Failure with Reduced Ejection Fraction: Does It Really Matter?
The conventional sequence of guideline-directed medical therapy (GDMT) initiation in heart failure with reduced ejection fraction (HFrEF) assumes that the effectiveness and tolerability of GDMT agents mirror their order of discovery, which is not true. In this review, the authors discuss flexible GDMT sequencing that should be permitted in special populations, such as patients with bradycardia, chronic kidney disease, or atrial fibrillation. Moreover, the initiation of certain GDMT medications may enable tolerance of other GDMT medications. Most importantly, the achievement of partial doses of all four pillars of GDMT is b...
Source: Cardiology Clinics - September 23, 2023 Category: Cardiology Authors: Jiun-Ruey Hu, Alexandra N. Schwann, Jia Wei Tan, Abdulelah Nuqali, Ralph J. Riello, Michael H. Beasley Source Type: research

What It Will Take to Avoid a Tripledemic This Winter
Over the coming months, more than 100,000 Americans will likely die, mostly unnecessarily, from respiratory infections. Yes, that is the reality we are now facing this fall and winter—and likely every fall and winter for the foreseeable future. Unless we act. Between flu, COVID-19, and RSV, we are likely looking at a very large number of Americans getting sick, ending up in the hospital, and dying. Most of these Americans will be our most vulnerable: older Americans, the youngest children, and those with chronic diseases. And that number of 100,000 may be an underestimate, given that many of these infections go undet...
Source: TIME: Health - September 22, 2023 Category: Consumer Health News Authors: Dr. Ashish K. Jha Tags: Uncategorized COVID-19 freelance Source Type: news

Sustainable healthcare is better for patients
Acting on climate change is often framed as having to give stuff up, to cost more money, to make sacrifices. Yet in healthcare we find the opposite can often be true: there are many actions we can take which reduce the carbon footprint of healthcare which actually end up with better outcomes for our patients. In this episode, we hear from two examples of that. Singing for breathing is a type of social prescribing to help people with chronic lung disease manage their breathlessness, reducing their need to be reliant on healthcare to do this, while also finding joy and a sense of community. Stephen is one patient who has be...
Source: The BMJ Podcast - September 22, 2023 Category: General Medicine Authors: BMJ Group Source Type: podcasts

Hepatitis C Linked to Cognitive Impairment in Older Adults
Older adults who have hepatitis C may have a higher risk of developing cognitive impairment, astudy in theAmerican Journal of Geriatric Psychiatry has found.Fu-Hsiung Su, M.D., Ph.D., of Fu Jen Catholic University in New Taipei City, Taiwan, and colleagues examined data from 23,781 participants aged 60 years or older whose information was available in the Taiwan Biobank in 2012. Among the participants, 912 had cognitive impairment as measured by the Taiwanese version of the Mini-Mental State Examination (MMSE). Participants received blood tests for hepatitis B and C as well as genetic testing.The researchers found the foll...
Source: Psychiatr News - September 22, 2023 Category: Psychiatry Tags: American Journal of Geriatric Psychiatry APOE cognitive impairment hepatitis B hepatitis C Source Type: research

Flexible Attention Sensory Training for Youth With Chronic Pain
Condition:   Persistent Pain Intervention:   Behavioral: Sensory Training Sponsor:   Stanford University Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Care Transitions App for Patients With Multiple Chronic Conditions
Conditions:   Heart Failure;   Congestive Heart Failure;   Diabetes;   Diabetes Mellitus;   Chronic Kidney Diseases Intervention:   Behavioral: Care Transitions App Sponsors:   Brigham and Women's Hospital;   Agency for Healthcare Research and Quality (AHRQ) Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Observational Study to Evaluate Efficacy, Safety and Biomarkers of Bulevirtide Treatment in Chronic Hepatitis D Patients
Condition:   Chronic Hepatitis D Intervention:   Drug: Bulevirtide Sponsor:   Karolinska University Hospital Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Reduced Intensive Idarubicin and Cytarabine Plus Venetoclax as First-line Treatment for Adults With Acute Myeloid Leukaemia and Myelodysplastic Syndrome
Conditions:   Acute Myeloid Leukemia;   Myelodysplastic Syndromes Interventions:   Drug: idarubicin;   Drug: Cytarabine Sponsor:   First Affiliated Hospital of Zhejiang University Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Phase 1b, Open-Label Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of EP262 in Subjects With Chronic Inducible Urticaria
Condition:   Chronic Inducible Urticaria Intervention:   Drug: Oral EP262 Sponsor:   Escient Pharmaceuticals, Inc Recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Progressive Relaxation Training Effect On Pain, Activity And Social Participation In Women With Tension-Type Headache And Migraine
Conditions:   Pain, Chronic;   Migraine Disorders;   Tension-Type Headache Intervention:   Other: PROGRESSIVE RELAXATION TRAINING Sponsor:   Hacettepe University Recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Digital Clinical Hypnosis for Chronic Pain Management
Condition:   Chronic Low-back Pain Intervention:   Behavioral: Hypnosis audio recordings Sponsors:   University of Washington;   National Center for Complementary and Integrative Health (NCCIH) Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Can Patients With Chronic Stroke Regain Living Independence by Daily Energizing With Biophoton Generators
Condition:   Chronic Stroke Intervention:   Device: Biophoton Energizing Brain and Whole Body Sponsor:   First Institute of All Medicines Recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
Conditions:   Obesity;   Hyperlipidemias;   Polycystic Ovary Syndrome;   Hypertension;   Coronary Heart Disease;   Heart Failure;   Depression, Anxiety;   Type II Diabetes;   Metabolic Syndrome Intervention:   Behavioral: Lifestyle counseling and coaching Sponsor:   West Virginia School of Osteopathic Medicine Not yet recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials

Scapular Stabilization vs Functional Exercises on Chronic Neck Pain
Condition:   Neck Pain Interventions:   Other: baseline physical therapy treatment along with scapular stabilization exercises;   Other: baseline physical therapy treatment along with scapular functional exercises Sponsor:   Riphah International University Recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials