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CT colonography tops colonoscopy for mapping colon cancer segmentationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CT colonography can pinpoint cancerous colorectal segments more accurately than colonoscopy, according to Italian investigators. They say virtual, not optical, colonoscopy should be the gold standard for the preoperative staging of colorectal cancer. (Source: Diagnostic Imaging)
Source: Diagnostic Imaging - November 21, 2009 Category: Radiology Source Type: info

Eat and drink your way to a healthy colon?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW YORK (Reuters Health) - Eating fruits and vegetables, and drinking tea and red wine may offer overweight men and normal weight women some protection from colon and rectal cancers, hint study findings from the Netherlands. (Source: Reuters: Health)
Source: Reuters: Health - November 20, 2009 Category: Consumer Health News Tags: healthNews Source Type: news

A Cancer-associated Aurora A Mutant Is Mislocalized and Misregulated Due to Loss of Interaction with TPX2 [Protein Structure and Folding]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we show that Aurora A kinase activity is altered in different ways in three somatic cancer-associated mutations located within the catalytic domain; Aurora A(V174M) shows constitutively increased kinase activity, Aurora A(S155R) activity is decreased primarily due to misregulation, and Aurora A(S361*) activity is ablated due to loss of structural integrity. These alterations suggest vastly different mechanisms for the role of these three mutations in human cancer. We have further characterized the Aurora A(S155R) mutant protein, found that its reduced cellular activity and mislocalization are due to loss of i...
Source: Journal of Biological Chemistry - November 20, 2009 Category: Chemistry Authors: Bibby, R. A., Tang, C., Faisal, A., Drosopoulos, K., Lubbe, S., Houlston, R., Bayliss, R., Linardopoulos, S. Tags: Protein Structure and Folding Source Type: journals

Screening for colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A record from the CRD Health Techology Assessment Database. Published in July 2009. (Source: Gastroenterology and Liver Diseases Specialist Library - Colon and rectum)
Source: Gastroenterology and Liver Diseases Specialist Library - Colon and rectum - November 20, 2009 Category: Gastroenterology Source Type: organizations

Obesity and CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exp Clin Endocrinol Diabetes 2009; 117: 563-566DOI: 10.1055/s-0029-1241870AbstractEpidemiological studies have suggested that obesity is associated with increased risk of several cancer types including colon, esophagus, breast (in postmenopausal women), endometrium, kidney, liver, gallbladder and pancreas. Suggested mechanisms include increased intake of potentially carcinogenic food ingredients along with excessive amount of calories, loss of cancer protective effects due to reduced physical activity, carcinogenic factors released from increased adipose tissue mass and “secondary” associations via “precu...
Source: Experimental and Clinical Endocrinology and Diabetes - November 19, 2009 Category: Endocrinology Tags: Mini-Review Source Type: journals

Avoiding midazolam overdose: summary of a safety report from the National Patient Safety AgencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ Online First)
Source: BMJ Online First - November 19, 2009 Category: Journals (General) Authors: Lamont, T., Matthew, L., Cousins, D., Green, J. Tags: Endoscopy, Patients, colon cancer, Child and adolescent psychiatry (paedatrics), Child health, Hospice, Child and adolescent psychiatry, Adult intensive care, Dentistry and oral medicine, Gastrointestinal surgery, General surgery, Poisoning, Medical error Source Type: journals

Association between Helicobacter pylori seropositivity and digestive tract cancers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma. PMID: 19916178 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Wu IC, Wu DC, Yu FJ, Wang JY, Kuo CH, Yang SF, Wang CL, Wu MT Tags: World J Gastroenterol Source Type: journals

Estrogen Deprivation Therapy and Colon Cancer Risk in Breast Cancer PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The Breast Journal)
Source: The Breast Journal - November 19, 2009 Category: Cancer & Oncology Authors: David O. Malaka, Olufunmilayo I. Olopade Source Type: journals

iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest that chemo- and immuno-resistance to anthracyclines are associated in colon cancer cells and rely on a common mechanism, that is the inability of doxorubicin to induce iNOS. Therefore NO donors might represent a promising strategy to restore both chemosensitivity and immunosensitivity to doxorubicin in resistant cells. (Source: Molecular Cancer)
Source: Molecular Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Sara De BooJoanna KopeckaDavide BrusaElena GazzanoLina MateraDario GhigoAmalia BosiaChiara Riganti Source Type: journals

Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Colonic cell proliferation was promoted via the JNK pathway in the presence of a HFD but not in the presence of a ND. This novel mechanism may explain the involvement of the JNK pathway in the effect of dietary fat intake on colon carcinogenesis. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Endo, H, Hosono, K, Fujisawa, T, Takahashi, H, Sugiyama, M, Yoneda, K, Nozaki, Y, Fujita, K, Yoneda, M, Inamori, M, Wada, K, Nakagama, H, Nakajima, A Tags: colon cancer Colorectal cancer Source Type: journals

International trials: Panitumumab delays disease progression in colon cancer metsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BERLIN—A pair of colon cancer trials using panitumumab (Vectibix) not only proved the efficacy of the drug in patients with nonmutated KRAS but also highlighted the importance of ascertaining KRAS status. Trial 181 evaluated panitumumab in combination with FOLFIRI as a second-line treatment for metastatic colorectal cancer, while trial 203 paired the anti-EGFR agent with FOLFOX4 as first-line treatment. (Source: Cancer Network)
Source: Cancer Network - November 18, 2009 Category: Cancer & Oncology Source Type: info

Ovarian cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ Online First)
Source: BMJ Online First - November 18, 2009 Category: Journals (General) Authors: Hamilton, W., Menon, U. Tags: Neurogastroenterology, Clinical trials (epidemiology), Epidemiologic studies, Stomach and duodenum, General practice / family medicine, Pain (neurology), Menopause (including HRT), colon cancer, Gynecological cancer, Screening (oncology), Radiology, Disab Source Type: journals

Novel nitro-oxy derivatives of celecoxib for the regulation of colon cancer cell growth.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) developed as a selective inhibitor of cyclooxygenase-2 (COX-2). Despite the associated cardiovascular toxicity risk, celecoxib has been found to be effective in reducing cancer risk in animal and human studies. In the present study the antiproliferative activity of novel nitro-oxy-methyl substituted analogues of celecoxib (NO-cel), potentially less cardiotoxic, has been investigated in vitro on human colon cancer cells and compared with action of the parent drug. Moreover, experiments were performed in order to evaluate whether COX-2 pharmacological inhibition...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Bozzo F, Bassignana A, Lazzarato L, Boschi D, Gasco A, Bocca C, Miglietta A Tags: Chem Biol Interact Source Type: journals

Clinical relevance associated to the analysis of circulating tumour cells in patients with solid tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The distant growth of tumour cells escaping from primary tumours, a process termed metastasis, represents the leading cause of death among patients affected by malignant neoplasias from breast and colon. During the metastasis process, cancer cells liberated from primary tumour tissue, also termed circulating tumour cells (CTCs), travel through the circulatory and/or lymphatic systems to reach distant organs. The early detection and the genotypic and phenotypic characterisation of such CTCs could represent a powerful diagnostic tool of the disease, and could also be considered an important predictive...
Source: Clinical and Translational Oncology - November 18, 2009 Category: Cancer & Oncology Tags: Clinical and Translational Oncology Source Type: journals

Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative statesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Colon tumors show differential expression of miRNAs depending on mismatch repair status. miRNA expression in colon tumors has an epigenetic component and altered expression that may reflect a reversion to regulatory programs characteristic of undifferentiated proliferative developmental states. (Source: BMC Cancer)
Source: BMC Cancer - November 18, 2009 Category: Cancer & Oncology Authors: Aaron SarverAmy FrenchPedro BorralhoVenugopal ThayanithyAnn ObergKevin SilversteinBruce MorlanShaun RiskaLisa BoardmanJulie CunninghamSubbaya SubramanianLiang WangTom SmyrkCecilia RodriguesStephen ThibodeauClifford Steer Source Type: journals

Systemic hernial disease protects against cancer: an hypothesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Research by herniologists from around the world has shown that abdominal defects, in the adult, are not caused by wear and tear but systemic hernial disease (herniosis), a disorder of connective tissue which affects the extracellular matrix (ECM). Wound healing may be affected, leading to recurrences after hernia repair or primary incisional herniation. Women with genitourinary prolapse show signs of herniosis in the pelvis. Diverticulosis coli, commonly seen in the elderly, like hernia, was once attributed to stress and strain from constipation. It is now suspected that herniosis weakens the coloni...
Source: Hernia - November 17, 2009 Category: Sports Medicine Tags: Hernia Source Type: journals

Patents on breast cancer genes are illegal and stymie research, say scientistsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ Online First)
Source: BMJ Online First - November 17, 2009 Category: Journals (General) Authors: Lenzer, J. Tags: Immunology (including allergy), Breast cancer, colon cancer, Molecular biology, Asthma NEWS Source Type: journals

Acute lower gastrointestinal haemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: BMJ Online First)
Source: BMJ Online First - November 17, 2009 Category: Journals (General) Authors: Edwards, A. J, Maskell, G. F Tags: Endoscopy, GI bleeding, Epidemiologic studies, Drugs: cardiovascular system, Stroke, Hypertension, colon cancer, Interventional cardiology, Radiology, Surgical diagnostic tests, Gastrointestinal surgery, General surgery, Radiology (diagnostics), Resuscita Source Type: journals

Unexplained liver hemorrhage after metastasis radiofrequency ablationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(World Journal of Gastroenterology) Radiofrequency ablation is a minimally invasive treatment of hepatic metastases from colon carcinoma, and can achieve good outcomes with low morbidity and mortality rates. Although relatively safe, liver radiofrequency ablation may have several complications, many of which are potentially grave. The most common complication is intra-abdominal hemorrhage with a rate of approximately 1.6 percent. Liver lacerations may also occur but only occasionally. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 17, 2009 Category: Global & Universal Source Type: news

Does Specialized Surgical Training Increase Lymph Node Yield in Colon Cancer?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The number of lymph nodes analyzed in specimens from patients undergoing resection for colon cancer has diagnostic and therapeutic importance. Low lymph node number is a risk factor for poor survival, particularly in patients with Stage II and Stage III disease. (Source: Cancercompass News: Colorectal Cancer)
Source: Cancercompass News: Colorectal Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news

Facile Synthesis and In-Vitro Antitumor Activity of Some Pyrazolo[3,4-b]pyridines and Pyrazolo[1,5-a]pyrimidines Linked to a Thiazolo[3,2-a]benzimidazole MoietyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The key precursor E-3-(N,N-dimethylamino)-1-(3-methylthiazolo[3,2-a]benzimidazol-2-yl)prop-2-en-1-one 4 was synthesized in good yield using Gold's reagent. The reaction of enaminone 4 with 5-amino-3-aryl-1-phenylpyrazoles 5a, b in refluxing acetic acid in the presence of sulphuric acid, yielded pyrazolo[3,4-b]pyridines 7a, b. Similarly, pyrazolo[1,5-a]pyrimidines 10a, b and 14a-f were prepared by reaction of enaminone 4 with 5-amino-1H-pyrazoles 8a, b and 12a-f, respectively. The structure of pyrazolo[1,5-a]pyrimidine 10b was determined by X-ray diffraction. The synthesized compounds were tested for their in-vitro antitumo...
Source: Archiv der Pharmazie - November 17, 2009 Category: Drugs & Pharmacology Authors: Hatem A. Abdel-Aziz, Tamer S. Saleh, Heba S. A. El-Zahabi Source Type: journals

Are patients with non-muscle-invasive bladder cancer a suitable population for a lung cancer screening trial?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To estimate the relative risk of developing a second primary neoplasm, in particular lung cancer, after having non-muscle-invasive bladder cancer (NMIBC). Patients were included in the study if they had developed NMIBC between 1995 and 2003. All clinical data were extracted from the medical records of our institution's database. The interval between neoplasms, smoking habits, histological subtypes and survival were also analysed. Patient follow-up was [ge]5 years. We found 231 patients with NMIBC, 39 of which had a second primary neoplasm: 10 lung cancer, one pancreas, one gastric, one pharynx, one liver, one parathyroid, ...
Source: BJU International - November 17, 2009 Category: Urology & Nephrology Authors: Javier del Rey, José Placer, Felip Vallmanya, Núria Pujol, Esther Prat, Rosa Miró, Antoni Gelabert Source Type: journals

Death After Colectomy: It's Later Than We Think [Original Article]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The 30-day mortality significantly underreports the true risk of death after CRS. The 90-day mortality rate should be included as a standard outcome measure after CRS because it serves as a better estimation of risk for counseling patients. (Source: Archives of Surgery)
Source: Archives of Surgery - November 16, 2009 Category: Surgery Authors: Visser, B. C., Keegan, H., Martin, M., Wren, S. M. Tags: Oncology, colon cancer, Surgery, Surgical Interventions, Colorectal Surgery, Prognosis/ Outcomes Original Article Source Type: journals

Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal AdenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, increased apoptosis and expression of Bax, not Bcl-2 or the Bax/Bcl-2 ratio, may play some role in the relatively lower incidence of human small intestinal carcinomas. However, more studies are required for a better understanding of these changes. (J Histochem Cytochem 57:1139–1148, 2009) (Source: Journal of Histochemistry and Cytochemistry)
Source: Journal of Histochemistry and Cytochemistry - November 16, 2009 Category: Biochemistry Authors: Gao, C., Wang, A.-Y. Tags: Articles Source Type: journals

Therapeutic Delay Reduces Survival of Rectal Cancer, but Not Colon CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A therapeutic delay of 60 days or longer is associated with decreased survival from rectal cancer, say researchers from Denmark in the October issue of the British Journal of Surgery. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 16, 2009 Category: Consumer Health News Tags: General Surgery Source Type: news

Randomized Clinical Trials in Colon CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Surgery remains the mainstay of treatment for colon cancer and surgical resection alone results in 5-year survival in more than 60% of patients. However, the use of fluorouracil (5-FU)-based adjuvant chemotherapy for patients at high risk of recurrence further prolongs disease-free survival and has become the standard of care. New areas of research focus on decreasing the surgical trauma with minimally invasive approaches, improving the surgical staging of patients with colon cancer, and improving adjuvant treatment regimens. We review those randomized controlled trials that have most impacted the clinical management of pa...
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: Heather B. Neuman, Jason Park, Martin R. Weiser Source Type: journals

Protein Might Prevent CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One difficulty with fighting cancer cells is that they are similar in a number of respects to the body's stem cells. By focusing on the differences, scientists at Karolinska Institutet have found a new way of tackling colon cancer. The study is presented in the prestigious journal Cell. Molecular signal pathways that stimulate the division of stem cells are generally the same as those active in tumour growth. This limits the possibility of treating cancer as the drugs that kill cancer cells also often adversely affect the body's healthy cells, especially stem cells. A newly released study from Karolinska Institutet, conduc...
Source: Medicineworld.org: New Article Alert - November 16, 2009 Category: Consumer Health News Source Type: info

Old Drugs, New Ways (XELIRI) to Treat Colon CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A newly published study highlights how combining existing cancer treatment medications in new ways can improve survival for those with advanced colorectal cancer. The chemotherapy combined two medications, capecitabine and irinotecan, in a treatment referred to as XELIRI. Researchers studied XELIRI treatment in 53 patients, more than half (55%) of whom were 65 years of age or older. The overall response rate (ORR) to XELIRI in this group was 32% and the disease control rate was estimated to be 66%. The median (similar to "average") survival in the group was 19.2 months, showing that even in people with metastatic (advanced...
Source: About.com Colon Cancer - November 16, 2009 Category: Cancer & Oncology Source Type: consumer

100,500 Cancers Per Year Due to ObesityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The American Institute for Cancer Research recently released new numbers on how obesity is linked to the number of cancer cases in the US each year. Not surprisingly, the numbers aren't good. When it comes to colon cancer, it is estimated that at least 13,200 cases each year are due to obesity. In other words, studies suggest that nearly 10%, or one-tenth, of all colon cancer cases never would occur each year if obesity were not a problem in the US. Other health experts believe this estimate is even on the low side. Another study on this topic suggests that about 30% of all colon cancer cases in the United States are due t...
Source: About.com Colon Cancer - November 16, 2009 Category: Cancer & Oncology Source Type: consumer

Aspirin Lengthens Survival in Patients With Nonmetastatic Colorectal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aspirin therapy inhibits the development of pre-cancerous colon adenomas. Does it also offer protection after colorectal cancer develops? Journal Watch (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 16, 2009 Category: Consumer Health News Tags: Internal Medicine Source Type: news

Prometheus releases trio of tissue-specific microRNA testsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prometheus Laboratories has launched the ProOncDx line of cancer diagnostic tests. ProOncDx TumorSource pinpoints the tissue of origin in metastatic tumors in a number of cancers including breast, brain, kidney, colon, liver, ovary, lung, pancreas, and prostate. The test measures the expression level of 48 microRNA biomarkers. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info

Therapeutic delay reduces survival of rectal cancer, but not colon cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW YORK (Reuters Health), Nov 16 - A therapeutic delay of 60 days or longer (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 16, 2009 Category: Radiology Source Type: info

Qigong Benefits People with CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
For people with cancer, a decrease in quality of life is one of the most difficult aspects of the disease to manage. Many struggle with fatigue and feelings of stress, anxiety, and depression. For people seeking non-medical ways of coping with cancer side effects, Qigong may offer relief. Qigong ("chee-kung") is a Chinese meditative practice which uses slow graceful movements and controlled breathing techniques to promote feeling calm, peaceful, and more content. The latest research on Qigong shows that when cancer patients regularly practice Qigong, it improves their overall quality of life, lessens fatigue, and helps dec...
Source: About.com Colon Cancer - November 16, 2009 Category: Cancer & Oncology Source Type: consumer

Malignancy Is Associated with Dermatomyositis But Not Polymyositis in Northern New England, USA.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The risk of cancer in IIM is concentrated among patients with DM. The association between DM and cancer was enhanced by its temporal relationship (< 1 year) in 87.5% of these cases. Patients with malignancy-associated DM were more frequently male and over age 45 and less likely to have interstitial lung disease. PMID: 19918034 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 16, 2009 Category: Rheumatology Authors: Antiochos BB, Brown LA, Li Z, Tosteson TD, Wortmann RL, Rigby WF Tags: J Rheumatol Source Type: journals

Folic Acid and B12 Supplements Increase Cancer RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study showed harm from folic acid supplements in a country that does not fortify its food supply with folic acid. The United States does fortify the food supply with folic acid. This means that we already get a supplemental form of this nutrient in our diets in high amounts. This also means that the harms of taking additional folic acid supplements are more likely to occur in people who are living in the US. The bottom line is that we should get our folic acid from foods naturally high in this nutrient, not from pills. No studies have ever shown that getting plenty of folic acid from food increases cancer risk. Plus, ...
Source: About.com Colon Cancer - November 16, 2009 Category: Cancer & Oncology Source Type: consumer

Oral agent improves survival in advanced bladder cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A drug that is commonly used to treat lung and colon cancer may prolong survival in patients with invasive bladder cancer, researchers reported at the American College of Surgeons clinical congress in Chicago. (Source: Modern Medicine)
Source: Modern Medicine - November 14, 2009 Category: Journals (General) Source Type: info

Conversion from laparoscopic to open colonic cancer resection – Associated factors and their influence on long-term oncological outcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Conversion of laparoscopic colon cancer resection worsens DFS in locally advanced stage II carcinoma. There is a need to reduce the conversion rate by adequate patient selection for laparoscopic resection by experienced surgeons. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: H. Ptok, R. Kube, U. Schmidt, F. Köckerling, I. Gastinger, H. Lippert, the “colon/Rectum carcinoma (Primary Tumor)” Study Group Tags: Original Articles Source Type: journals

Paradoxical Protein Might Prevent CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One difficulty with fighting cancer cells is that they are similar in many respects to the body's stem cells. By focusing on the differences, researchers at Karolinska Institutet have found a new way of tackling colon cancer. The study is presented in the prestigious journal Cell. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 14, 2009 Category: Consumer Health News Tags: Colorectal cancer Source Type: news

Paradoxical Protein Might Prevent CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One difficulty with fighting cancer cells is that they are similar in many respects to the body's stem cells. By focusing on the differences, researchers at Karolinska Institutet have found a new way of tackling colon cancer. The study is presented in the prestigious journal Cell. Molecular signal pathways that stimulate the division of stem cells are generally the same as those active in tumour growth. (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - November 14, 2009 Category: Biochemistry Tags: Colorectal cancer Source Type: news

Compound In Coffee Brewing New Research In Colon, Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A compound in coffee has been found to be estrogenic in studies by Texas AgriLife Research scientists. Though the studies have not been conducted to determine recommended consumption amounts, scientists say the compound, called trigonelline or "trig," may be a factor in estrogen-dependent breast cancer but beneficial against colon cancer development. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 14, 2009 Category: Consumer Health News Tags: Colorectal cancer Source Type: news

Compound In Coffee Brewing New Research In Colon, Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A compound in coffee has been found to be estrogenic in studies by Texas AgriLife Research scientists. Though the studies have not been conducted to determine recommended consumption amounts, scientists say the compound, called trigonelline or "trig," may be a factor in estrogen-dependent breast cancer but beneficial against colon cancer development. "The important thing to get from this is that 'trig' has the ability to act like a hormone," said Dr. (Source: Breast Cancer News From Medical News Today)
Source: Breast Cancer News From Medical News Today - November 14, 2009 Category: Cancer & Oncology Tags: Colorectal cancer Source Type: news

Optimizing lymphadenectomy in laparoscopic surgery for colon cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory LetterDOI 10.1007/s00464-009-0747-1Authors Christof Hottenrott, Chirurgische Klinik St. Elisabethenkrankenhaus Frankfurt Germany Journal Surgical EndoscopyOnline ISSN 1432-2218Print ISSN 0930-2794 (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - November 14, 2009 Category: Surgery Tags: Surgical Endoscopy Source Type: journals

Coffee Break: Compound Brewing New Research In Colon, Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A compound in coffee has been found to be estrogenic. Scientists say the compound, called trigonelline or "trig," may be a factor in estrogen-dependent breast cancer but beneficial against colon cancer development. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 13, 2009 Category: Science Source Type: news

Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The family of mammalian chitinases includes members both with and without glycohydrolase enzymatic activity against chitin, a polymer of N-acetylglucosamine. Chitin is the structural component of fungi, crustaceans, insects and parasitic nematodes, but is completely absent in mammals. Exposure to antigens containing chitin- or chitin-like structures sometimes induces strong T helper type-I responses in mammals, which may be associated with the induction of mammalian chitinases. Chitinase 3-like-1 (CHI3L1), a member of the mammalian chitinase family, is induced specifically during the course of inflammation in such diso...
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Eurich K, Segawa M, Toei-Shimizu S, Mizoguchi E Tags: World J Gastroenterol Source Type: journals

An integrative approach of cancer treatment with mistletoe therapy, surgery, irradiation and chemotherapy in CAM settingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In the settings investigated, an integrative approach was predominantly chosen when VA was administered. VA is used on a large variety of entities, predominantly by sc application. It is possible to differentiate between short- and long-term users but no data are yet available if there is a correlation between the length of treatment and either a curative use or the intention to improve quality. These data will provide a solid basis for the comparison of clinical trial data with routine use.Acknowledgements: This project was supported by Weleda AG, Helixor GmbH, and Abnoba GmbH. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: F. Schad, A. Merkle, V. Hoffmann, G. Lenneweit, G. Spahn, M. Hesse, C. Paxino, G. Wellmann, B. Matthes, R. Baute, T. Breitkreuz, H. Matthes Source Type: journals

Paradoxical protein might prevent cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Karolinska Institutet) One difficulty with fighting cancer cells is that they are similar in many respects to the body's stem cells. By focusing on the differences, researchers at Karolinska Institutet have found a new way of tackling colon cancer. The study is presented in the prestigious journal Cell. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 13, 2009 Category: Global & Universal Source Type: news

Bacillus calmette-guerin cell wall cytoskeleton enhances colon cancer radiosensitivity through autophagy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The cell wall skeleton of Mycobacterium bovis Bacillus Calmette-Guerin (BCG/CWS) is an effective antitumor immunotherapy agent. Here, we demonstrate that BCG/CWS has a radiosensitizing effect on colon cancer cells through the induction of autophagic cell death. Exposure of HCT116 colon cancer cells to BCG/CWS before ionizing radiation (IR) resulted in increased cell death in a caspase-independent manner. Treatment with BCG/CWS plus IR resulted in the induction of autophagy in colon cancer cells. Either the autophagy inhibitor 3-methyladenine or knockdown of beclin 1 or Atg7 significantly reduced tumor cell death induce...
Source: Autophagy - November 13, 2009 Category: Cytology Authors: Yuk JM, Shin DM, Song KS, Lim K, Kim KH, Lee SH, Kim JM, Lee JS, Paik TH, Kim JS, Jo EK Tags: Autophagy Source Type: journals

Short-term outcomes from a prospective randomized trial comparing laparoscopic and open surgery for colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Randomized trials in low-risk populations have failed to show any benefit for laparoscopic compared with open colorectal resection in terms of morbidity. Furthermore, it is not known whether laparoscopic colorectal resection would yield advantages if randomization were revealed during surgery after a diagnostic laparoscopy.Patients with cancer of the colon or upper rectum were randomly assigned to laparoscopic or open resection. All patients underwent diagnostic laparoscopy to assess whether laparoscopic resection was feasible and the result of randomization was then revealed to the surgeon. Main endpoints were overall, ge...
Source: British Journal of Surgery - November 13, 2009 Category: Surgery Authors: J. Neudecker, F. Klein, R. Bittner, T. Carus, A. Stroux, W. Schwenk, on behalf of the LAPKON II Trialists Tags: Original Articles Source Type: journals

[The impact of obesity on the histopathological characteristics of colorectal tumours. An observational study.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Patients with a higher BMI have more lymph node metastasis when submitted to elective colorectal cancer surgery. In the case of colon cancer they also have worst tumour grades, and in the case of rectal cancer, a more advanced tumour stage. PMID: 19914612 [PubMed - as supplied by publisher] (Source: Cirugia eEspanola)
Source: Cirugia eEspanola - November 13, 2009 Category: Surgery Authors: García-Oria Serrano MJ, Armengol Carrasco M, Ortiz R, Codina Cazador A Tags: Cir Esp Source Type: journals