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Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We review whether endometriosis-associated ovarian cancer is a specific entity compared with ovarian cancer not associated with endometriosis, with respect to epidemiology, natural history, and clinical diagnosis; we present a review of the English-language literature for ovarian cancer in endometriosis with respect to these three features. A recent prospective study in Japan directly showed that, during a follow-up of up to 17 years of an ovarian endometrioma cohort (n = 6398), 46 incident ovarian cancers were identified, showing that the ovarian cancer risk was significantly elevated in patients w...
Source: International Journal of Clinical Oncology - October 24, 2009 Category: Cancer & Oncology Tags: International Journal of Clinical Oncology Source Type: journals

CDX-2 expression is a common event in primary intestinal-type endocervical adenocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We studied the expression of cytokeratin (CK) 7, CK20, CDX-2, and p16 in 119 cervical adenocarcinomas (65 usual type [50 invasive; 15 in situ], 37 intestinal type [21 invasive; 16 in situ], 10 endometrioid, 5 adenosquamous, and 2 signet-ring carcinomas) in comparison with 55 cases of rectal adenocarcinomas. The percentage of cells staining was considered negative if 0% to 5% stained; more than 5% was considered positive. For p16, staining of more than 50% was considered positive. CK7 was expressed in all cervical cases and in 12 rectal adenocarcinomas (22%). CK20 was expressed in 17 cervical adenocarcinomas (14.3%) and...
Source: American Journal of Clinical Pathology - September 21, 2009 Category: Pathology Authors: Saad RS, Ismiil N, Dubé V, Nofech-Mozes S, Khalifa MA Tags: Am J Clin Pathol Source Type: journals

Adenosquamous carcinoma of the ovary arising from endometriosis: two case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The author reports two cases of adenosquamous carcinoma arising from endometriosis of ovaries. The tumor patients were 38-year-old and 53-year-old women. Both patients underwent hysterectomy and bilateral salpingo-oophorectomy for ovarian carcinomas. Grossly, both ovarian tumors were located in the left ovaries, and were cystic tumors with mural tumors. Histologically, the cystic areas consisted of endometrial glandular epithelium. Both mural tumors were composed of grade I endometroid adenocarcinoma and squamous cell carcinoma. These two elements were admixed in some areas. A differentiation of endometrioid adenocarcinoma...
Source: Cases Journal - August 2, 2009 Category: Journals (General) Source Type: journals

Clinicopathological significance of cyclin A, p27 and Skp2 in ovarian epithelial tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cyclin A and skp2 expression is related to the development of ovarian carcinomas. However, we could not find a significant alteration of p27 expression in ovarian adenocarcinomas. (Source: Basic and Applied Pathology)
Source: Basic and Applied Pathology - May 18, 2009 Category: Pathology Authors: Jin Hyung Heo, Kwang Il Kim, Sun Young Lee, Tae Heon Kim, Haeyoun Kang, Hee Jung An Source Type: journals

PRK1 distribution in normal tissues and carcinomas: overexpression and activation in ovarian serous carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Protein kinase C–related kinases are regulated by phosphatidylinositol-3-kinase and Rho family GTPases. The isoform PRK1 has been characterized in detail in prostate cancer, but not in other carcinomas. We analyzed our prior microarray data for PRK1 gene expression in 175 carcinomas and evaluated tissue microarrays for protein expression in 251 carcinomas and a comprehensive group of normal tissues. We also used immunoblotting to determine the levels and phosphoactivation status of PRK1, PRK2, and PDK1 in 12 ovarian serous carcinomas, SKOV3 cells, and 3 samples of normal ovarian surface epithelium (OSE). The hig...
Source: Human Pathology - May 7, 2009 Category: Pathology Authors: Mary T. Galgano, Mark Conaway, Adam M. Spencer, Bryce M. Paschal, Henry F. Frierson Tags: Original Contributions Source Type: journals

Miscellaneous Uterine Malignant Neoplasms Detected during Hysteroscopic SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Resectoscopic surgery in women with miscellaneous uterine malignant lesions not adversely affect 5-year survival and long-term prognosis. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - May 1, 2009 Category: OBGYN Authors: George A. Vilos, Fawaz Edris, Basim Abu-Rafea, Jackie Hollett-Caines, Helen C. Ettler, Awatif Al-Mubarak Tags: Original Articles Source Type: journals

Reproducibility determination of WHO classification of endometrial hyperplasia / well differentiated adenocarcinoma and comparison with computerized morphometric data in curettage specimens In Iran.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: It may be necessary to make some revisions in WHO classification for endometrial hyperplasia and precancerous lesions. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - March 25, 2009 Category: Pathology Authors: Narges Izadi-Mood, Maryam Yarmohammadi, Seyed Ali Ahmadi, Guity Irvanloo, Hayedeh Haeri, Ali Pasha Meysamie and Mahmood Khaniki Source Type: journals

Comparative proteomic study of two closely related ovarian endometrioid adenocarcinoma cell lines using cIEF fractionation and pathway analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The proteomic profiles from two distinct ovarian endometrioid tumor-derived cell lines, (MDAH-2774 and TOV-112D) each with different morphological characteristics and genetic mutations, have been studied. Characterization of the differential global protein expression between these two cell lines has important implications for the understanding of the pathogenesis of ovarian endometrioid carcinoma. In this comparative proteomic study, extensive fractionation of peptides generated from whole-cell trypsin digestion was achieved by coupling cIEF in the first-dimensional separation with capillary LC (RP-HPLC) in the second dime...
Source: Electrophoresis - March 16, 2009 Category: Biochemistry Authors: Lan Dai, Chen Li, Kerby A. Shedden, David E. Misek, David M. Lubman Source Type: journals

Clinicopathological characteristics of mucinous adenocarcinoma of the ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The diagnosis of mucinous invasive adenocarcinoma was difficult. Since patients with mucinous invasive adenocarcinoma had a lower response to chemotherapy, aggressive cytoreductive surgery was an effective treatment to improve the prognosis for advanced stage patients. A new chemotherapeutic regimen should be established for mucinous adenocarcinoma of the ovary. PMID: 19275957 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 9, 2009 Category: Cancer & Oncology Authors: Shimada M, Kigawa J, Ohishi Y, Yasuda M, Suzuki M, Hiura M, Nishimura R, Tabata T, Sugiyama T, Kaku T Tags: Gynecol Oncol Source Type: journals

Synchronous primary cancers of the endometrium and ovary: review of 43 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Synchronous primary cancers of the endometrium and ovary were different from either the primary endometrial or ovarian cancer, while usually it can be detected in early stage with a good prognosis. The impact of the CA125 level on prognosis needs to be further studied. Surgery treatment alone may be enough for early stage patients. Chemotherapy plus radiotherapy may be necessary for advanced patients. Content Type Journal ArticleDOI 10.1007/s10330-008-0146-4Authors Shaokang Ma, Chinese Academy of Medical Sciences Department of Gynecologic Oncology, Caner Hospital, Peking Union Medical Coll...
Source: The Chinese-German Journal of Clinical Oncology - February 14, 2009 Category: Cancer & Oncology Tags: The Chinese-German Journal of Clinical Oncology Source Type: journals

Primary Undifferentiated Ovarian Carcinoma Diagnosed by its Metastasis to Brain: An Unusual Case Report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Although metastasis from undifferentiated ovarian carcinomas to the central nervous system have been published with the CNS disease often developing long after the initial diagnosis of primary tumour; simultaneous diagnosis of primary undifferentiated carcinoma of the ovary and its CNS metastasis as described in our case may rarely occur. PMID: 19107695 [PubMed - as supplied by publisher] (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - December 26, 2008 Category: Neurosurgery Authors: Bakar B, Tekkök IH Tags: Turk Neurosurg Source Type: journals

[Gynecologic Cancer] Carcinoma of the Lower Uterine Segment: A Newly Described Association With Lynch SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The prevalence of Lynch syndrome in patients with LUS endometrial carcinoma (29%) is much greater than that of the general endometrial cancer patient population (1.8%) or in endometrial cancer patients younger than age 50 years (8% to 9%). On the basis of our results, the possibility of Lynch syndrome should be considered in women with LUS tumors. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - December 18, 2008 Category: Cancer & Oncology Authors: Westin, Lacour, Urbauer, Luthra, Bodurka, Lu, Broaddus Tags: Epidemiology, Diagnosis & Staging Gynecologic Cancer Source Type: journals

Primary sex cord-like variant of endometrioid adenocarcinoma arising from endometriosis Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kauppila S, Altinörs M, Väre P, Liakka A, Knuuti E, Nissi R. Primary sex cord-like variant of endometrioid adenocarcinoma arising from endometriosis. Case report. APMIS 2008;116:842[ndash]5. Endometriosis, a relatively common disease generally affecting women in the reproductive age group, is mostly found in the pelvic organs. Although endometriosis is a benign disease, some malignant tumors have been reported to develop in endometriotic lesions, most commonly in the ovary. The relationship between endometriosis and malignancy is not well known, but the majority of endometriosis-associated ovarian malignancies are usuall...
Source: APMIS - December 5, 2008 Category: Research Authors: SAILA KAUPPILA, MEHMET ALTINÖRS, PÄIVI VÄRE, ANNIKKI LIAKKA, EILA KNUUTI, RITVA NISSI Tags: Case report Source Type: journals

Cyr61, a member of ccn (connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed) family, predicts survival of patients with endometrial cancer of endometrioid subtype.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Cyr61 is highly expressed in some endometrial cancer of endometrioid subtype. Cyr61 expression and positive LNM were independent prognostic factors for patients with endometrioid adenocarcinoma. Cyr61 might be a new molecular marker to predict the prognosis of patients with endometrioid adenocarcinoma. PMID: 19007976 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - November 11, 2008 Category: Cancer & Oncology Authors: Watari H, Xiong Y, Hassan MK, Sakuragi N Tags: Gynecol Oncol Source Type: journals

Combined large cell neuroendocrine carcinoma and papillary serous carcinoma of the endometrium with pagetoid spread.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the first case, to our knowledge, of combined large cell neuroendocrine carcinoma and papillary serous carcinoma of the endometrium, with an unusual pagetoid spread of the neuroendocrine component into normal endometrial and endocervical glands. The endometrial carcinoma had a small serous component, but most of the tumor was characterized by solid sheets of medium to large cells with abundant mitotic figures, numerous apoptotic bodies, and foci of necrosis. This component was diffusely positive for neuroendocrine markers. Following surgery, the patient was treated with radiation therapy and chemotherapy. She was...
Source: Archives of Pathology and Laboratory Medicine - November 1, 2008 Category: Laboratory Medicine Authors: Posligua L, Malpica A, Liu J, Brown J, Deavers MT Tags: Arch Pathol Lab Med Source Type: journals

Association between ovarian endometriosis and malignancy in the peri-menopausal period: report of two cases and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two cases of peri-menopausal women in which endometriosis was associated to ovarian malignancy. The first case was a 49-year-old woman who underwent laparoscopic oophorectomy for an ovarian endometrioid cyst. Definitive histology showed ovarian endometrioid cyst with endometrioid and clear cell carcinoma. Subsequently, surgical restaging was performed. The other case was a 49-year-old woman who underwent hysterectomy and bilateral oophorectomy for an ovarian mass suggestive of endometriosis and uterine myomas. At frozen section examination, ovarian adenocarcinoma was found and staging procedure was performed...
Source: Gynecological Surgery - September 25, 2008 Category: OBGYN Tags: Gynecological Surgery Source Type: journals

High frequency of RASSF1A and RARb2 gene promoter methylation in morphologically normal endometrium adjacent to endometrioid adenocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Promoter region methylation of RASSF1A and RARb2 genes is an early event in endometrial carcinogenesis. PMID: 18783461 [PubMed - as supplied by publisher] (Source: Histopathology)
Source: Histopathology - September 8, 2008 Category: Pathology Authors: Arafa M, Kridelka F, Mathias V, Vanbellinghen JF, Renard I, Foidart JM, Boniver J, Delvenne P Tags: Histopathology Source Type: journals

Endometrial Effects of Tibolone in Elderly, Osteoporotic Women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Tibolone treatment during 3 years minimally increased endometrial thickness, hyperplastic polyps, endometrial carcinoma, and vaginal bleeding. CLINICAL TRIAL REGISTRATION: ClinicalTrials.org, www.clinicaltrials.org, NCT00519857 LEVEL OF EVIDENCE: I. PMID: 18757665 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - September 1, 2008 Category: OBGYN Authors: Ettinger B, Kenemans P, Johnson SR, Mol-Arts M, Van Os S, Seifert W, Verweij PJ, Cummings SR Tags: Obstet Gynecol Source Type: journals

CD10 Immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this study demonstrated differences in the CD10 immunoreactivity or immunostaining pattern between the stromal components of APA and myoinvasive endometrial carcinoma. This difference should lead to a more accurate diagnosis of APA (pseudo-myoinvasive lesion). Furthermore, the histogenesis of APA may perhaps be explained by "myofibromatous metaplasia" of the endometrial stromal cells. PMID: 18619643 [PubMed - as supplied by publisher] (Source: American Journal of Surgery)
Source: American Journal of Surgery - July 10, 2008 Category: Surgery Authors: Ohishi Y, Kaku T, Kobayashi H, Aishima S, Umekita Y, Wake N, Tsuneyoshi M Tags: Hum Pathol Source Type: journals

Transitional cell carcinoma of the endometrium and endometrial carcinoma with transitional cell differentiation: a clinicopathologic study of 5 cases and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To date, only 16 cases of transitional cell carcinoma of the endometrium and endometrial carcinoma with transitional cell differentiation have been reported in the literature. We reviewed the clinicopathologic features of 5 cases of endometrial carcinoma with transitional cell differentiation. The mean age was 68 years, and all patients presented with postmenopausal bleeding. Macroscopically, the tumors were intracavitary and friable. Microscopically, the tumors were composed of tightly packed papillary structures with thin fibrovascular cores, resembling a transitional cell carcinoma of the urinary tract. One tumor sh...
Source: Human Pathology - July 10, 2008 Category: Pathology Authors: Mariño-Enríquez A, González-Rocha T, Burgos E, Stolnicu S, Mendiola M, Nogales FF, Hardisson D Tags: Hum Pathol Source Type: journals

Uterine Carcinosarcomas and Grade 3 Endometrioid Cancers: Evidence for Distinct Tumor Behavior.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Carcinosarcomas present at more advanced stage and have worse survival than grade 3 endometrioid carcinomas. Carcinosarcomas may represent a distinct biologic entity. LEVEL OF EVIDENCE: II. PMID: 18591309 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - July 1, 2008 Category: OBGYN Authors: Bansal N, Herzog TJ, Seshan VE, Schiff PB, Burke WM, Cohen CJ, Wright JD Tags: Obstet Gynecol Source Type: journals

[Expression and methylation of adenomatous polyposis coli gene in endometrioid adenocarcinoma.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The expression and DNA methylation of APC gene are certainly related with the occurrence and development of endometrioid adenocarcinoma. PMID: 18570730 [PubMed - in process] (Source: Chinese Journal of Cancer)
Source: Chinese Journal of Cancer - June 1, 2008 Category: Cancer & Oncology Authors: Qian B, Ke PQ, Wang L, Liu WJ, Li MX Tags: Ai Zheng Source Type: journals

Imaging of endometrioid adenocarcinoma of the uterus metastatic to the ciliary body.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 60-year-old woman with endometrioid adenocarcinoma (stage FIGO II) presented with left eye pain. A hysterectomy was to be preceded by pelvic radiation therapy (45 Gy). Ophthalmic examination with high frequency ultrasonography revealed a ciliary body tumor with iris extension. Positron emission tomography and computed tomography fusion revealed multifocal metastatic disease. A Finger iridectomy technique ciliary body tumor biopsy revealed metastatic endometrioid adenocarcinoma. Treatment with external beam radiation therapy (3,060 cGy in 17 daily fractions) resolved her ocular disease. Subsequent and rapidly evolving...
Source: Ophthalmic Surgery, Lasers and Imaging : the Official Journal of the International Society for Imaging in the Eye - May 1, 2008 Category: Opthalmology Authors: Akcaer M, Milman T, Finger PT Tags: Ophthalmic Surg Lasers Imaging Source Type: journals

Biopsy histomorphometry predicts uterine myoinvasion by endometrial carcinoma: a Gynecologic Oncology Group study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A barrier to nonsurgical management of premalignant endometrial disease is the need to perform hysterectomy to exclude concurrent myoinvasive endometrioid adenocarcinoma. Occult adenocarcinoma rates for premalignant disease diagnosed by biopsy or curettage are approximately 40%. We applied the histomorphometric 4-class rule ("4C," which measures epithelial abundance, thickness, and nuclear variation) to diagnostic biopsies to predict myoinvasive cancer outcomes at hysterectomy. Women with endometrial biopsies or curettages having a community diagnosis of atypical endometrial hyperplasia were enrolled in a clinical tria...
Source: Human Pathology - April 22, 2008 Category: Pathology Authors: Mutter GL, Kauderer J, Baak JP, Alberts D Tags: Hum Pathol Source Type: journals

Endometrioid endometrial adenocarcinoma recurring as carcinosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Obstetrics and Gynaecology Research, Volume 34, Issue 2, Page 279-282, April 2008. Abstract Müllerian carcinosarcoma is currently regarded as a metaplastic (sarcomatous) carcinoma. Only five cases of pure ovarian adenocarcinoma recurring as carcinosarcoma have been documented in the literature. There are no documented cases of ... (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - April 16, 2008 Category: OBGYN Tags: article Source Type: journals

The role of omentectomy during the surgical staging in patients with clinical stage I endometrioid adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We conclude that despite the presence of normal-appearing omentum, omentectomy should be performed as a component of surgical staging in the presence of positive peritoneal cytology. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-008-0389-zAuthors Jale Metindir, Ankara Oncology Education and Research Hospital Department of Gynecology Ahmet Mithat Efendi Sok No: 58/11 06550 Çankaya/Ankara TurkeyGülay Bilir Dilek, Ankara Oncology Education and Research Hospital Department of Pathology Ankara Turkey Journal Journal of Cancer Research and Clinical OncologyOnline ...
Source: Journal of Cancer Research and Clinical Oncology - April 3, 2008 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: journals

Lymphovascular space invasion does not predict vaginal relapses in stage I endometrioid adenocarcinoma of the endometrium.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was conducted to determine whether, in a pure population of patients with International Federation of Gynecology and Obstetrics stage I endometrioid endometrial (S1EE) carcinoma that is confined to the uterus and without lymph node metastases, the presence of lymphovascular space invasion (LVSI) is positively associated with vaginal relapses. Pathologic reports for all S1EE diagnosed in a hysterectomy specimen during a 9-year period (1997-2005) were reviewed. Cases with LVSI were selected and immunohistochemical staining for CD34, factor VIII-related antigen and pancytokeratin were performed on the relevant slid...
Source: Annals of Diagnostic Pathology - March 8, 2008 Category: Pathology Authors: Desrosiers L, Fadare O, Xiao ZF, Dresser K, Wang SA Tags: Ann Diagn Pathol Source Type: journals

Precise measurement of the E-cadherin repressor Snail in formalin-fixed endometrial carcinoma using protein lysate microarraysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our results fit to the proposed function of Snail as a transcriptional repressor of E-cadherin and Cytokeratin 18 in primary human carcinomas and demonstrate the usefulness of protein lysate microarrays for the precise determination of proteins involved in epithelial-mesenchymal-transition. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s10585-008-9149-3Authors Susanne Hipp, Technical University of Munich Institute of Pathology Trogerstrasse 18 81675 Munich GermanyAxel Walch, GSF-National Research Centre for Environment and Health Institute of Pathology Neuherberg GermanyTibor Schuster...
Source: Clinical and Experimental Metastasis - February 29, 2008 Category: Cancer & Oncology Tags: Clinical and Experimental Metastasis Source Type: journals

Expression of aquaporin-1 in normal, hyperplasic, and carcinomatous endometria.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: AQP1 may be involved in the tumorigenesis and progression of endometrioid adenocarcinoma by promoting angiogenesis, and AQP1 level may be both a tumor indicator and a new therapeutic target. PMID: 18313673 [PubMed - as supplied by publisher] (Source: International Journal of Gynaecology and Obstetrics)
Source: International Journal of Gynaecology and Obstetrics - February 28, 2008 Category: OBGYN Authors: Pan H, Sun CC, Zhou CY, Huang HF Tags: Int J Gynaecol Obstet Source Type: journals

Tumor-associated macrophages correlate with vascular space invasion and myometrial invasion in endometrial carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Although on univariate analysis TAMs are associated with other poor prognosticators, on a multivariate analysis, TAMs appear only to be associated with MI and VI. TAMs may play a significant role in the biology of tumor progression of endometrial adenocarcinoma, but do not appear to be independent prognostic indicators of patient's survival. PMID: 18289648 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 18, 2008 Category: Cancer & Oncology Authors: Soeda S, Nakamura N, Ozeki T, Nishiyama H, Hojo H, Yamada H, Abe M, Sato A Tags: Gynecol Oncol Source Type: journals

[My approach] My approach to and thoughts on the typing of ovarian carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian carcinomas of epithelial type comprise a heterogeneous group of neoplasms, each with a different underlying pathogenesis and natural behaviour. Accurate classification of ovarian carcinomas is important since each type may be associated with a different behaviour, natural history and outcome. Precise classification is also critical to determine whether alternative therapeutic strategies are appropriate for different tumour types. Previous studies have shown significant interobserver variation in the typing of ovarian carcinomas. There are several areas where there are particular difficulties; these include the dist...
Source: Journal of Clinical Pathology - January 25, 2008 Category: Pathology Authors: McCluggage, W G Tags: My approach Source Type: journals

[Original articles] BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1{alpha} pathway and prognosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: BNIP3 seems to be an important hypoxia-regulated molecule involved in endometrial cancer pathology. Given that high BNIP3 reactivity, being linked with poor post-operative outcome, has been linked with a favourable response to cytotoxic therapy (as previously indicated in experimental studies), high BNIP3 expression may be an indicator for adjuvant chemoradiotherapy in stage I endometrial carcinomas. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - January 25, 2008 Category: Pathology Authors: Giatromanolaki, A, Koukourakis, M I, Gatter, K C, Harris, A L, Sivridis, E Tags: Original articles Source Type: journals

Primary fallopian tube carcinoma associated with ovulation induction; a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of a 38-year-old woman with primary infertility and a history of three ovulation inductions with gonadotropin-releasing hormone agonist and gonadotrophins, referred for treatment of bilateral ovarian cysts, which were discovered in the beginning of the last cycle. During laparotomy, bilateral adnexal masses were identified, presumed to be of ovarian origin, and total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy, and retroperitoneal lymph nodes sampling were performed. Histologic examination showed a primary right fallopian tube endometrioid adenocarcinoma and bilateral ...
Source: International Journal of Gynecological Cancer - January 22, 2008 Category: Cancer & Oncology Authors: A. DELIVELIOTOU, D. HASSIAKOS, S. FOTIOU, E. KARVOUNI, G. CREATSAS Tags: ORIGINAL ARTICLES Source Type: journals

Neoangiogenesis and expression of hypoxia-inducible factor 1alpha, vascular endothelial growth factor, and glucose transporter-1 in endometrioid type endometrium adenocarcinomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: HIF-1alpha was increasingly expressed from early stages through advance stages of endometrioid adenocarcinoma, paralleled by activation of its downstream genes such as GLUT-1, VEGF and increased angiogenesis. These results highlight the importance of hypoxia and related pathways in progression of endometrial carcinoma. PMID: 18191183 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - January 10, 2008 Category: Cancer & Oncology Authors: Ozbudak IH, Karaveli S, Simsek T, Erdogan G, Pestereli E Tags: Gynecol Oncol Source Type: journals

Prohibitin silencing reverses stabilization of mitochondrial integrity and chemoresistance in ovarian cancer cells by increasing their sensitivity to apoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current approaches to the treatment of ovarian cancer are limited because of the development of resistance to chemotherapy. Prohibitin (Phb1) is a possible candidate protein that contributes to development of drug resistance, which could be targeted in neoplastic cells. Phb1 is a highly conserved protein that is associated with a block in the G0/G1 phase of the cell cycle and also with cell survival. Our study was designed to determine the role of Phb1 in regulating cellular growth and apoptosis in ovarian cancer cells. Our results showed that Phb1 content is differentially overexpressed in papillary serous ovarian carcino...
Source: International Journal of Cancer - January 8, 2008 Category: Cancer & Oncology Authors: Rosalind C. Gregory-Bass, Moshood Olatinwo, Wei Xu, Roland Matthews, Jonathan K. Stiles, Kelwyn Thomas, Dong Liu, Benjamin Tsang, Winston E. Thompson Source Type: journals

Ovarian endometrioma-Risks factors of ovarian cancer development.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Some endometriosis lesions may predispose to clear cell and endometrioid ovarian cancers. Advancing age and the size of endometriomas were independent predictors of development of ovarian cancer among women with ovarian endometrioma. PMID: 18162283 [PubMed - as supplied by publisher] (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - December 24, 2007 Category: OBGYN Authors: Kobayashi H, Sumimoto K, Kitanaka T, Yamada Y, Sado T, Sakata M, Yoshida S, Kawaguchi R, Kanayama S, Shigetomi H, Haruta S, Tsuji Y, Ueda S, Terao T Tags: Eur J Obstet Gynecol Reprod Biol Source Type: journals

No Metastatic Cervical Adenocarcinomas in a Series of p16INK4a-Positive Mucinous or Endometrioid Advanced Ovarian Carcinomas: An Analysis of the AGO Ovarian Cancer Study Group.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 18DOI: 10.1097/pgp.0b013e318074b83fAuthors: Wentzensen, Nicolas M.D.; Bois, Andreas du M.D.; Kommoss, Stefan M.D.; Pfisterer, Jacobus M.D.; von Knebel Doeberitz, Magnus M.D.; Schmidt, Dietmar M.D.; Kommoss, Friedrich M.D. (Source: International Journal of Gynecological Pathology)
Source: International Journal of Gynecological Pathology - December 22, 2007 Category: Pathology Tags: Abstract HTML PDF (1.612 M) Source Type: journals

Four synchronous female genital malignancies: the ovary, cervix, endometrium and fallopian tubeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion When compared with patients having metastatic lesions, most synchronous female malignancies are accompanied with early stage and low-grade with a more favorable prognosis. However, there is paucity of data for the exact criterion to distinguish primary tumors from metastatic lesions. In such cases, the validity of immunohistochemical and cloning studies are not clear. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-007-0520-4Authors Arzu Saglam, Hacettepe University School of Medicine Department of Pathology Ankara TurkeyGurkan Bozdag, Hacettepe University School of Med...
Source: Archives of Gynecology and Obstetrics - December 8, 2007 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Endometrioid carcinoma of the endometrium with choriocarcinomatous differentiation: a case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Although endometrioid adenocarcinoma with choriocarcinomatous differentiation is known to behave in a more aggressive course, this disease may have a good prognosis with a clinically indolent course when it is small, and without elevated serum hCG levels. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-007-0526-yAuthors Metin Akbulut, Pamukkale University School of Medicine Department of Pathology Morfoloji Binasi, Kinikli 20070 Denizli TurkeyHulya Tosun, Pamukkale University School of Medicine Department of Pathology Morfoloji Binasi, Kinikli 20070 Denizli TurkeyMehmet E...
Source: Archives of Gynecology and Obstetrics - December 8, 2007 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Neither ovariectomy nor progestin treatment prevents endometrial neoplasia in pten(+/-) mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS.: Development of endometrial neoplasms and constitutive activation of the PI3K pathway in pten(+/-) mice is not affected by hormonal ablation or by progestin treatment. Loss of PTEN expression is common during human endometrial cancer development, and this may render lesions resistant to the effects of hormonal manipulation leading to treatment failure. PMID: 18048091 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - November 27, 2007 Category: Cancer & Oncology Authors: Fyles A, Wood G, Li M, Manoukian AS, Gowing K, Khokha R, Chapman W, Tsao MS Tags: Gynecol Oncol Source Type: journals

Molecular alterations in the pathogenesis of endometrial adenocarcinoma. Therapeutic implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Molecular genetic evidence indicates that endometrial carcinoma likely develops as the result of a multistep process of oncogene activation and tumor suppressor gene inactivation. These molecular alterations appear to be specific for Type I (endometrioid) and Type II (non endometrioid) cancers. Type I cancers are characterized by mutation of PTEN, KRAS2, defects in DNA mismatch repair, as evidenced by the microsatellite instability phenotype, and a near diploid karyotype. Type II cancers often contain mutations of TP53 and Her-2/neu and are usually nondiploid. The clinical value of many of these mole...
Source: Clinical and Translational Oncology - August 4, 2007 Category: Cancer & Oncology Tags: Clinical and Translational Oncology Source Type: journals

Adenomyosis involved by endometrial adenocarcinoma is a significant risk factor for deep myometrial invasion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study of grade 1 endometrioid adenocarcinoma investigates whether patients with cancer-positive adenomyosis are at a different risk for deep myometrial invasion compared with those with cancer-negative adenomyosis. Ninety-three hysterectomy specimens with FIGO (International Federation of Gynecologists and Obstetricians) grade 1 endometrial endometrioid adenocarcinoma associated with adenomyosis were studied. Four experienced gynecologic pathologists retrospectively reviewed all hematoxylin and eosin-stained sections. Myometrial invasion was confirmed by CD10-negative staining around glands with jagged outline surroun...
Source: Annals of Diagnostic Pathology - July 17, 2007 Category: Pathology Authors: Ismiil N, Rasty G, Ghorab Z, Nofech-Mozes S, Bernardini M, Ackerman I, Thomas G, Covens A, Khalifa MA Tags: Ann Diagn Pathol Source Type: journals

The Pathology of Endometriosis: A Survey of the Many Faces of a Common Disease Emphasizing Diagnostic Pitfalls and Unusual and Newly Appreciated AspectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although the histologic diagnosis of endometriosis is usually straightforward, many diagnostic problems can arise as a result of alterations or absence of its glandular or stromal components. The diagnostic difficulty in such cases can be compounded by tissue that is limited to a small biopsy specimen. The appearance of the glandular component can be altered by hormonal and metaplastic changes, as well as cytologic atypia and hyperplasia. Although the last 2 findings are often referred to collectively as "atypical endometriosis," they should be separately recognized as their premalignant potential likely differs. In some c...
Source: Advances in Anatomic Pathology - June 30, 2007 Category: Pathology Tags: Review Articles Source Type: journals

Small primary adenocarcinoma in adenomyosis with nodal metastasis: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Adenocarcinoma in adenomyosis may be affected by local hormonal influence and, despite its small size, may metastasize. (Source: BioMed Central)
Source: BioMed Central - June 20, 2007 Category: Journals (General) Authors: Giacomo Puppa, Makio Shozu, Tiziana Perin, Kazuhito Nomura, Annunziata Gloghini, Elio Campagnutta and Vincenzo Canzonieri Source Type: journals

B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS.: B7-H4 is overexpressed in hyperplastic and malignant endometrial epithelium and is correlated with the number T cells associated with the tumor. These results suggest that B7-H4 overexpression may reflect a more aggressive biologic potential and may play a role in tumor immune surveillance mechanisms. PMID: 17509674 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 15, 2007 Category: Cancer & Oncology Authors: Miyatake T, Tringler B, Liu W, Liu SH, Papkoff J, Enomoto T, Torkko KC, Dehn DL, Swisher A, Shroyer KR Tags: Gynecol Oncol Source Type: journals

Malignant ovarian tumor composed of endometrioid adenocarcinoma, clear cell adenocarcinoma, squamous cell carcinoma, yolk sac tumor and immature teratoma with prominent neuroectodermal and rhabdomyosarcomatous differentiation: A case study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION.: No previous cases with an identical composition have been found in the literature. Correct diagnosis of this complex and aggressive tumor is paramount. PMID: 17341430 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 1, 2007 Category: Cancer & Oncology Authors: Ohishi Y, Kaku T, Kaneki E, Wake N, Tsuneyoshi M Tags: Gynecol Oncol Source Type: journals

From Krukenberg to Today: The Ever Present Problems Posed by Metastatic Tumors in the Ovary. Part IIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This is the second of a two-part consideration of metastatic tumors to the ovary. Here, the matter is considered in 16 categories, largely site-specific. The first tumor discussed is gastric carcinoma of intestinal-type whose ovarian manifestations have been the subject of a recent paper which emphasized its differences from the Krukenberg tumor. Coverage of intestinal adenocarcinoma emphasizes the landmark 1987 paper of RH Lash and WR Hart. The section on pancreatic neoplasms reemphasizes the problems caused by metastatic ductal carcinoma, considered primarily in Part I, and discusses less common issues such as spread of ...
Source: Advances in Anatomic Pathology - April 30, 2007 Category: Pathology Tags: Review Articles Source Type: journals

[Article] Mouse Model of Human Ovarian Endometrioid Adenocarcinoma Based on Somatic Defects in the Wnt/β-Catenin and PI3K/Pten Signaling PathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
By Rong Wu, Neali Hendrix-Lucas, Rork Kuick, Yali Zhai, Donald R. Schwartz, Aytekin Akyol, Samir Hanash, David E. Misek, Hidetaka Katabuchi, Bart O. Williams, Eric R. Fearon, and Kathleen R. Cho. One histologic subtype of ovarian carcinoma, ovarian endometrioid adenocarcinoma (OEA), frequently harbors mutations that constitutively activate Wnt/β-catenin-dependent signaling. We now show that defects in the... (Source: Cancer Cell)
Source: Cancer Cell - April 10, 2007 Category: Cancer & Oncology Source Type: journals

Localized amyloidosis in endometrioid carcinoma of the uterus: a rare associationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This is an unusual case of amyloidosis associated with endometrioid carcinoma of the uterus. Content TypeJournal Article JournalArchives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - April 5, 2007 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Immunocytochemistry for hepatocyte nuclear factor-1[beta] (HNF-1[beta]): A marker for ovarian clear cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent microarray studies have shown that the expression of hepatocyte nuclear factor-1[beta] (HNF-1[beta]) was significantly up-regulated in clear cell carcinoma (CCC) of the ovary. HNF-1[beta] may be a useful marker for CCC in peritoneal fluid cytology. We designed an experimental study using three CCC cell lines to evaluate the influence of alcohol fixation or air drying on immunocytochemistry for HNF-1[beta]. Each cell line was cultured on chamber slides or transplanted into the abdominal cavity of nude mice, then the slides or ascites smears of nude mice were immunostained with or without microwave-mediated epitope re...
Source: Diagnostic Cytopathology - April 1, 2007 Category: Pathology Authors: Noriko Kato, Michiko Toukairin, Izumi Asanuma, Teiichi Motoyama Source Type: journals