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This page shows you the latest news and research items in this category.

Clinical management of atypical polypoid adenomyoma of the uterus. A clinicopathological review of 29 cases.
CONCLUSION: The clinical outcome of APAM is benign. However, differential diagnosis should be performed because of its histological similarity to invasive endometrial carcinoma and the possibility of coexistence with other endometrial neoplasms. TCR is a recommended diagnostic and treatment option for patients who desire to preserve fertility. PMID: 23290989 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - January 3, 2013 Category: Cancer & Oncology Authors: Matsumoto T, Hiura M, Baba T, Ishiko O, Shiozawa T, Yaegashi N, Kobayashi H, Yoshikawa H, Kawamura N, Kaku T Tags: Gynecol Oncol Source Type: research

Recurrence-free and 5-year survival following robotic-assisted surgical staging for endometrial carcinoma.
CONCLUSIONS: The results from this study demonstrate that robotic-assisted surgical staging for endometrial cancer does not adversely affect rates of recurrence or survival. These findings provide further evidence that robotic-assisted laparoscopic surgical staging is not associated with inferior results when compared to laparotomy or traditional laparoscopy. PMID: 23262377 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - December 20, 2012 Category: Cancer & Oncology Authors: Kilgore JE, Jackson AL, Ko EM, Soper JT, Van Le L, Gehrig PA, Boggess JF Tags: Gynecol Oncol Source Type: research

Technical challenges and limitations of current mouse models of ovarian cancer
The development of genetically engineered models (GEM) of epithelial ovarian cancer (EOC) has been very successful, with well validated models representing high grade and low grade serous adenocarcinomas and endometrioid carcinoma (EC). Most of these models were developed using technologies intended to target the ovarian surface epithelium (OSE), the cell type long believed to be the origin of EOC. More recent evidence has highlighted what is likely a more prevalent role of the secretory cell of the fallopian tube in the ontogeny of EOC, however none of the GEM of EOC have demonstrated successful targeting of this importan...
Source: Journal of Ovarian Research - November 29, 2012 Category: Cancer & Oncology Authors: Kenneth GarsonLisa GamwellElizabeth PitreBarbara Vanderhyden Source Type: research

Endometrioid adenocarcinoma of the ovary arising in atypical endometriosis.
In this study, the author reviewed 15 cases of endometrioid adenocarcinoma of the ovary in the last 15 years of our pathology laboratory in search for the presence of endometriosis within the tumor. Six (40%) of the 15 endometrioid adenocarcinoma were found to have endometriosis in the tumor. All of the endometriosis were atypical. The age of the 6 patients ranged from 44 year to 78 year with a median of 59 years. Grossly, the endometrial adenocarcinomas with endometriosis were characterized by unilocular cystic tumors in 5 cases and multilocular cystic tumor in one case. Histologically, the grade of endometrioid carcinoma...
Source: International Journal of Clinical and Experimental Pathology - November 15, 2012 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Trop-2 protein overexpression is an independent marker for predicting disease recurrence in endometrioid endometrial carcinoma
Background: Endometrial cancer is the most common gynecologic malignancy in developed countries. Trop-2 is a glycoprotein involved in cellular signal transduction and is differentially overexpressed relative to normal tissue in a variety of human adenocarcinomas, including endometrioid endometrial carcinomas (EEC). Trop-2 overexpression has been proposed as a marker for biologically aggressive tumor phenotypes. Methods: Trop-2 protein expression was quantified using tissue microarrays consisting of formalin-fixed paraffin-embedded specimens from 118 patients who underwent surgical staging from 2001--9 by laparotomy for EEC...
Source: BMC Clinical Pathology - Latest articles - November 14, 2012 Category: Pathology Authors: Eliana BignottiLaura ZanottiStefano CalzaMarcella FalchettiSilvia LonardiAntonella RavaggiChiara RomaniPaola TodeschiniElisabetta BandieraRenata TassiFabio FacchettiEnrico SartoriSergio PecorelliDana RoqueAlessandro Santin Source Type: research

Prognostic value of tgfb1 protein in endometrioid adenocarcinoma
In this study, the mRNA and protein expression profiles of two key regulators of angiogenesis, vascular endothelial growth factor (VEGF) and transforming growth factor beta‐1 (TGFB1), were evaluated by real‐time PCR and Western blot analysis in twenty‐three endometrial cancer tissue‐paired specimens (malignant versus adjacent normal tissues). We aimed to investigate whether VEGF and TGFB1 serve as markers of the malignant transformation of the endometrium and whether VEGF or TGFB1 expression can constitute a useful prognostic marker of survival in patients with endometrial carcinoma. Results: Tissue‐pair analy...
Source: European Journal of Clinical Investigation - October 10, 2012 Category: Journals (General) Authors: Giannoula Soufla, Stavros Sifakis, Filippos Porichis, Demetrios A. Spandidos Source Type: research

Adenocarcinoma of the lower female genital tract in patients with Herlyn-Werner-Wunderlich syndrome
We report 2 patients with Herlyn-Werner-Wunderlich syndrome, 1 with advanced endometrioid adenocarcinoma of the semiobstructed side of the uterine cervix and 1 with primary clear cell carcinoma of the obstructed side of the upper vagina. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - September 17, 2012 Category: OBGYN Authors: Yoh Watanabe, Tomomaro Etoh, Hidekatsu Nakai Tags: Case Reports Source Type: research

microRNAs related to angiogenesis are dysregulated in endometrioid endometrial cancer
STUDY QUESTION Which is the role of microRNAs (miRNAs) related to several angiogenesis regulators such as VEGF-A (Vascular endothelial growth factor-A) and TSP-1 (Thrombospondin-1) in endometrial cancer? SUMMARY ANSWER A dysregulated expression of miRNAs related to angiogenesis and an increase in the VEGF-A levels were observed in endometrial cancer in comparison with control. The different expression of miRNAs could modulate the expression of angiogenic and antiangiogenic factors, which may play an important role in the pathogenesis of endometrial cancer. WHAT IS KNOWN ALREADY Dysregulated miRNA expression has been prev...
Source: Human Reproduction - September 14, 2012 Category: Reproduction Medicine Authors: Ramon, L. A., Braza-Boils, A., Gilabert, J., Chirivella, M., Espana, F., Estelles, A., Gilabert-Estelles, J. Tags: Reproductive biology Source Type: research

High grade serous carcinoma of the ovary with a yolk sac tumour component in a postmenopausal woman: report of an extremely rare phenomenon
High grade serous carcinoma is the most common ovarian epithelial malignancy.1 Ovarian yolk sac tumours (YST) are much more uncommon and are morphologically heterogeneous, primitive teratoid neoplasms differentiating into multiple endodermal structures.2 They almost always occur before age 30 and are extremely rare in perimenopausal and postmenopausal women. Rare examples have been reported in elderly patients, sometimes associated with an ovarian surface epithelial-stromal tumour, most commonly endometrioid adenocarcinoma but occasionally carcinosarcoma, clear cell carcinoma or a mucinous neoplasm; rarely the epithelial c...
Source: Journal of Clinical Pathology - August 28, 2012 Category: Pathology Authors: Varia, M., McCluggage, W. G., Oommen, R. Tags: PostScript Source Type: research

Phase I Study of the Anti-Angiogenic Antibody Bevacizumab and the mTOR / Hypoxia-Inducible Factor Inhibitor Temsirolimus Combined with Liposomal Doxorubicin.
CONCLUSIONS: Patients tolerated bevacizumab and temsirolimus together with liposomal doxorubicin. Further evaluation, especially in patients with parotid, metaplastic breast and endometrial endometrioid cancer, and in patients with PIK3CA and/or PTEN aberrations is warranted. PMID: 22927482 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - August 27, 2012 Category: Cancer & Oncology Authors: Moroney J, Fu S, Moulder SL, Falchook GS, Helgason T, Levenback CF, Hong DS, Naing A, Wheler JJ, Kurzrock R Tags: Clin Cancer Res Source Type: research

The clinical significance of inflammatory cytokines in primary cell culture in endometrial carcinoma
This study was therefore undertaken to determine the relationship between cytokine production in primary cell culture and clinical outcome in endometrial adenocarcinoma. Fresh endometrial tissues were fractionated into epithelial and stromal fractions and cultured. After 6–7 days, supernatants were collected and cells enumerated. Batched aliquots were assayed using ELISA kits specific for CSF-1, GMCSF, G-CSF, TNF-α, IL-6, IL-8, and VEGF. Data were compared using ANOVA, Fisher's exact, and log rank tests. Increased epithelial VEGF production was observed more often in tumors with Type 2 variants (p = 0.039) and when GP...
Source: Molecular Oncology - August 20, 2012 Category: Cancer & Oncology Authors: Harriet O. Smith, Nicole D. Stephens, Clifford R. Qualls, Tal Fligelman, Tao Wang, Chang-Yun Lin, Elizabeth Burton, Jeffrey K. Griffith, Jeffrey W. Pollard Tags: Papers Source Type: research

Clinicopathologic study of endometrial dedifferentiated endometrioid adenocarcinoma: a case report.
We report herein a first case of endometrial dedifferentiated endometrioid carcinoma in a 51-year old woman in Chinese population. We performed immunoperoxidase studies for 12 markers. Among them, cytokeratins, keratin 7, keratin 18, EMA, estrogen receptor (ER), progesterone receptor (PR), and vimentin show significantly differential expression between differentiated and undifferentiated area. PMID: 22295150 [PubMed - indexed for MEDLINE] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - August 10, 2012 Category: Pathology Authors: Shen Y, Wang Y, Shi Y, Liu J, Liu Y Tags: Int J Clin Exp Pathol Source Type: research

A novel low dose fractionation regimen for adjuvant vaginal brachytherapy in early stage endometrioid endometrial cancer.
CONCLUSION: Vaginal brachytherapy alone in early-stage endometrial cancer provides excellent results in terms of locoregional control and disease-free survival. The fractionation scheme of 24Gy in 6 fractions prescribed to the cylinder surface was well-tolerated with minimal late toxicity. PMID: 22850411 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - July 28, 2012 Category: Cancer & Oncology Authors: Townamchai K, Lee L, Viswanathan AN Tags: Gynecol Oncol Source Type: research

UbcH10 Expression in Benign, Hyperplastic, and Malignant Endometrial Curetted Materials: A Tissue Microarray Study
The aim of this study was to investigate the role of UbcH10 expression in the differential diagnosis of benign, hyperplastic, and malignant endometrial tissues and also the relationship of UbcH10 with the clinicopathologic parameters of malignant cases. A tissue microarray was performed for 81 endometrial curettage biopsies, which histological diagnosis had demonstrated to be 13 cases of proliferative endometrium, 7 cases of disordered proliferative endometrium, 5 cases of complex atypical hyperplasia, 24 cases of nonatypical hyperplasia, and 32 cases of endometrioid adenocarcinoma. Expression of UbcH10 was assessed by imm...
Source: International Journal of Surgical Pathology - July 16, 2012 Category: Pathology Authors: Kefeli, M., Yildiz, L., Celik, H., Tosun, M., Karagoz, F. Tags: Original Articles Source Type: research

Port-Site Metastasis After Laparoscopic Surgical Staging of Endometrial Cancer: A Systematic Review of the Published and Unpublished Data
Abstract: Port-site metastases, also called trocar-site metastasis, have been described after laparoscopic surgery for non-gynecological and gynecological cancers. The aim of this review was to obtain evidence for port-site metastases after laparoscopic surgical staging of endometrial cancer. A systematic search of published and unpublished cases of port-site metastases after laparoscopic staging of endometrial cancer was conducted. All the authors responsible for correspondence were contacted to obtain any missing data. The patients' characteristics and oncologic, surgical, and safety data were recorded and analyzed. Twel...
Source: The Journal of Minimally Invasive Gynecology - June 28, 2012 Category: OBGYN Authors: Stefano Palomba, Angela Falbo, Tiziana Russo, Giovanni Battista La Sala Tags: Clinical Case Reviews Source Type: research

Insulin-like growth factors in endometrioid adenocarcinoma: Correlation with clinicopathological features and estrogen receptor expression
Conclusions: Insulin-like growth factor system plays an important role in estrogen-induced endometrial carcinogenesis, and overexpression of insulin-like growth factor-1R in the advanced endometrioid adenocarcinoma is not estrogen-dependent. (Source: BMC Cancer)
Source: BMC Cancer - June 21, 2012 Category: Cancer & Oncology Authors: Qun HaoHui-Ming ZhangYuan-Zhe WuYuan-Jiao Liang Source Type: research

Endometrioid ovarian carcinoma in a woman with a history of infertility and multiple in‐vitro fertilization treatment cycles
We present a case of endometrioid adenocarcinoma that developed during the ovarian stimulation process and show corresponding ultrasound images of its development. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd. (Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - June 15, 2012 Category: Radiology Authors: A. Richards, T. Boogert, M. Livingstone, C. Dalrymple Tags: Case Report Source Type: research

LMX1A as a Prognostic Marker in Ovarian Mucinous Cystadenocarcinoma.
This study aimed to evaluate the relationship of LMX1A and osteopontin (OPN) expression with clinicopathologic parameters for the 4 most common ovarian surface epithelial carcinomas. Both biomarkers were investigated immunohistochemically using tissue microarrays of 249 specimens including 91 serous cystadenocarcinomas, 56 mucinous cystadenocarcinomas, 64 endometrioid adenocarcinomas, 26 clear cell carcinomas, and 12 normal ovarian tissues. All 4 carcinomas showed significant expression of LMX1A and OPN. In addition, higher immunostaining scores and percentage of cells stained for LMX1A in mucinous cystadenocarcinomas corr...
Source: American Journal of Clinical Pathology - May 16, 2012 Category: Pathology Authors: Lin CK, Chao TK, Lai HC, Lee HS Tags: Am J Clin Pathol Source Type: research

Discovered on gastrointestinal stromal tumours 1 (DOG1) expression in non‐gastrointestinal stromal tumour (GIST) neoplasms
Conclusions: Our study supports that DOG‐1 is a highly sensitive and specific marker for GISTs and also highlights hitherto unrecognized and unusual patterns of expression in non‐mesenchymal neoplasms. (Source: Histopathology)
Source: Histopathology - May 9, 2012 Category: Pathology Authors: Jessica Hemminger, O Hans Iwenofu Source Type: research

Atypical polypoid adenomyomas progressed to endometrial endometrioid adenocarcinomas
Conclusions The truth that APA may have a chance to progress to carcinoma suggests that APA is at least an indicator lesion for the development of EEC, and highlights that clinicians should carefully monitor the patients, and a meticulous follow-up examination is mandatory. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-4DOI 10.1007/s00404-012-2355-xAuthors Hong Kai Zhang, Department of Pathology, Beijing Fuxing Hospital affiliated to the Capital University of Medical Sciences, Beijing Fuxing Menwai Street #20, Beijing, 100038 ChinaWei Dong Chen, Department of Pathology, Beijing Fux...
Source: Archives of Gynecology and Obstetrics - May 3, 2012 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: research

Overexpression and ratio disruption of ΔNp63 and TAp63 isoform equilibrium in endometrial adenocarcinoma: correlation with obesity, menopause, and grade I/II tumors
Conclusions These results indicate that both p63 isoforms and especially ΔNp63 play an important role in the development and progression of grade I/II endometrial adenocarcinoma, especially in obese and late-menopause women. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00432-012-1200-8Authors Eleni Vakonaki, Laboratory of Clinical Virology, Medical School, University of Crete, P.O. Box 2208, Heraklion, 71003 Crete, GreeceNikolaos Soulitzis, Laboratory of Clinical Virology, Medical School, University of Crete, P.O. Box 2208, Heraklion, 71003 Crete, GreeceStavros Sifakis, D...
Source: Journal of Cancer Research and Clinical Oncology - March 23, 2012 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: research

Mucinous histology is a risk factor for nodal metastases in endometrial cancer.
CONCLUSION: Mucinous differentiation was found to be an independent predictor of lymph node metastasis in the study population. Comprehensive surgical staging including retroperitoneal node dissection should be strongly considered in all endometrial cancer patients with predominantly mucinous histology. PMID: 22410328 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - March 9, 2012 Category: Cancer & Oncology Authors: Musa F, Huang M, Adams B, Pirog E, Holcomb K Tags: Gynecol Oncol Source Type: research

MicroRNA‐34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma
In this study, we compared miRNA expression levels in ESC with the levels in endometrial endometrioid adenocarcinoma (EEC) and normal endometria. Six miRNAs were identified as having aberrant down‐regulation specific to ESC with miR‐34b being most pronounced. miR‐34b was found to have promoter hypermethylation, which when reversed, restored miR‐34b expression in the cell lines treated with 5‐aza‐2′ deoxycytidine (DAC). Ectopic expression of miR‐34b in turn inhibited cell growth, migration and most notably invasion. Our findings suggest a relationship among p53 mutation, miR‐34b promoter methylation and tu...
Source: International Journal of Cancer - February 28, 2012 Category: Cancer & Oncology Authors: Eri Hiroki, Fumihiko Suzuki, Jun‐ichi Akahira, Satoru Nagase, Kiyoshi Ito, Jun‐ichi Sugawara, Yasuhiro Miki, Takashi Suzuki, Hironobu Sasano, Nobuo Yaegashi Tags: Cancer Cell Biology Source Type: research

Colonic Carcinoma Metastatic to the Endometrium: The Importance of Clinical History in Averting Misdiagnosis as a Primary Endometrial Carcinoma
Metastases to endometrium are a rare event. A case of a 53-year-old woman with a previous colon cancer presenting with a dysfunctional uterine bleeding is reported. The curettage specimens consisted of multiple fragments of proliferative endometrial tissue mixed with irregular glands, focally amputated, lined by very cells with elongated, hyperchromatic nuclei and solid sheets of neoplastic cells often filled with necrotic debris and inflammatory cells, resembling endometrioid adenocarcinoma. Neoplastic cells resulted positive at immunohistochemical reaction for CK20, CDX2, p53 and negative for CK7, vimentin, ER, and PR su...
Source: International Journal of Surgical Pathology - February 15, 2012 Category: Pathology Authors: Zannoni, G. F., Vellone, V. G., Fadda, G., Petrillo, M., Scambia, G. Tags: Case Reports Source Type: research

Lymphadenectomy in endometrial cancer: what's the right question?
We read, with great interest, the article by Sharma et al, in which, in a large retrospective study on data from the National Cancer Institute's Surveillance, Epidemiology, and End Results database, the authors analyzed women with stages I-II endometrioid adenocarcinomas of the uterine corpus treated between 1988 and 2006. Findings suggest that, especially among women with high- to intermediate-risk tumors, patients who undergo lymphadenectomy are less likely to receive external-beam radiation. According to the authors, data support lymphadenectomy for the majority of women with endometrial carcinoma, thus sparing radiatio...
Source: American Journal of Obstetrics and Gynecology - February 10, 2012 Category: OBGYN Authors: Stefano Basile, Maria Giovanna Salerno, Pierluigi Benedetti Panici Tags: Letters to the Editors Source Type: research

Clinicopathologic study of endometrial dedifferentiated endometrioid adenocarcinoma: a case report.
We report herein a first case of endometrial dedifferentiated endometrioid carcinoma in a 51-year old woman in Chinese population. We performed immunoperoxidase studies for 12 markers. Among them, cytokeratins, keratin 7, keratin 18, EMA, estrogen receptor (ER), progesterone receptor (PR), and vimentin show significantly differential expression between differentiated and undifferentiated area. PMID: 22295150 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 7, 2012 Category: Pathology Authors: Shen Y, Wang Y, Shi Y, Liu J, Liu Y Tags: Int J Clin Exp Pathol Source Type: research

Progestin intrauterine device in an adolescent with grade 2 endometrial cancer.
CONCLUSION: : A progestin-releasing IUD may be a valid treatment option for grade 2 endometrial cancer in young women who desire to retain fertility. PMID: 22270425 [PubMed - in process] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - January 26, 2012 Category: OBGYN Authors: Brown AJ, Westin SN, Broaddus RR, Schmeler K Tags: Obstet Gynecol Source Type: research

Claudin7 and moesin in endometrial Adenocarcinoma; a retrospective study of 265 patients
Conclusion: A significant prognostic value of MSN and CLDN7 in predicting disease outcomes in patients with EC was not demonstrated. Nevertheless, the high percentage of EC cases with MSN and CLDN7 immunoexpression, and their association with tumor grade and subtypes, suggests that these proteins might play a role in tumorigenesis of endometrial adenocarcinomas. Future studies are needed to shed light on their mechanistic properties in EC cells. (Source: BMC Research Notes)
Source: BMC Research Notes - January 24, 2012 Category: Research Authors: Paulette Mhawech-FaucegliaDan WangShashikant LelePeter FrederickTanja PejovicSong Liu Source Type: research

Pathology of endometrioid carcinoma.
This article describes anatomopathological and molecular features of this disease. Type I carcinoma, the most frequent, develops in a context of hyperoestrogenia. Endometrial glandular hyperplasia is the precursor lesion. The histological type is an endometrioid carcinoma. Its prognosis is good. Type II carcinoma is less frequent. It occurs on an atrophic mucosa. It is usually a more aggressive tumor like serous adenocarcinoma, clear cells carcinoma or carcinosarcoma with a poor prognosis. Type I and type II carcinoma also present different molecular pathways. PTEN inactivation, an early event in carcinogenesis, is the mos...
Source: Bulletin du Cancer - January 9, 2012 Category: Cancer & Oncology Authors: Albertini AF, Devouassoux-Shisheboran M, Genestie C Tags: Bull Cancer Source Type: research

Collision of three histologically distinct endometrial cancers of the uterus.
We described a 70-yr-old patient who complained of abnormal vaginal bleeding with a collision tumor of the uterine corpus. The patient received total hysterectomy, bilateral salphingo-oophorectomy, bilateral pelvic-paraaortic lymphadenectomy, omentectomy, and intraperitoneal chemotherapy. The uterine corpus revealed three separate masses, which were located at the fundus, anterior and posterior wall. Each tumor revealed three pathologically different components, which were malignant mixed müllerian tumor, papillary serous carcinoma, and endometrioid adenocarcinoma. Among these components, only the papillary serous carcino...
Source: J Korean Med Sci - January 1, 2012 Category: Journals (General) Authors: Jang KS, Lee WM, Kim YJ, Cho SH Tags: J Korean Med Sci Source Type: research

Endoplasmic reticulum stress is activated in endometrial adenocarcinoma.
CONCLUSIONS: The increased expression of ER stress markers in endometrioid endometrial carcinomas suggests a role for ER stress, the UPR and, possibly, GRP78 in endometrial cancer. Whether this mechanisms have a substantial function in the pathogenesis of malignant transformation of human endometrium is still under investigation in our laboratory. PMID: 22146569 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - December 3, 2011 Category: Cancer & Oncology Authors: Bifulco G, Miele C, Di Jeso B, Beguinot F, Nappi C, Di Carlo C, Capuozzo S, Terrazzano G, Insabato L, Ulianich L Tags: Gynecol Oncol Source Type: research

A prospective blinded comparison of the accuracy of transvaginal sonography and frozen section in the assessment of myometrial invasion in endometrial cancer.
CONCLUSION: Intraoperative FS performed better than preoperative TVS in the assessment of myometrial invasion by endometrial cancer. Despite being time-consuming, FS can be regarded as a useful modality in order to decide whether to perform lymphadenectomy in cases with poor visualization of the endometrium at TVS and when TVS gives inconclusive results. PMID: 22108256 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - November 18, 2011 Category: Cancer & Oncology Authors: Savelli L, Testa AC, Mabrouk M, Zannoni L, Ludovisi M, Seracchioli R, Scambia G, De Iaco P Tags: Gynecol Oncol Source Type: research

Dedifferentiated Endometrioid Adenocarcinoma of the Uterus: A Clinicopathologic Study of a Case
We report herein a case of endometrial dedifferentiated endometrioid carcinoma in a 45-year old lady with ovarian metastasis from the undifferentiated component. The primary endometrial tumor showed an undifferentiated component in an otherwise low grade endometrioid carcinoma. The undifferentiated component of these tumors can be misdiagnosed as the solid component of FIGO grade 3 in a pure endometrioid carcinoma. The recognition of an undifferentiated component in an otherwise low grade endometrioid carcinoma is very important, since dedifferentiated endometrioid adenocarcinoma has a worse prognosis when compared with FI...
Source: International Journal of Surgical Pathology - November 15, 2011 Category: Pathology Authors: Vita, G., Borgia, L., Di Giovannantonio, L., Bisceglia, M. Tags: Case Reports Source Type: research

E-cadherin nuclear staining is useful for the diagnosis of ovarian adult granulosa cell tumor
Summary: We recently have demonstrated nuclear localization of E-cadherin in ovarian adult granulosa cell tumors (Histopathology 2011;58:423). The purpose of the present study is to investigate the diagnostic utility of E-cadherin nuclear staining for the differential diagnosis between ovarian adult granulosa cell tumor and its morphological mimics. Tissue samples taken from 81 ovarian tumors and 20 extraovarian tumors were immunohistochemically stained using monoclonal anti–E-cadherin antibody recognizing cytoplasmic domain (clone 36 supplied by BD Biosciences, San Jose, CA). The ovarian tumors consisted of 30 adult gra...
Source: Human Pathology - November 14, 2011 Category: Pathology Authors: Yoshihiro Ohishi, Shuichi Kurihara, Tadahisa Takeuchi, Murasaki Aman, Tsunehisa Kaku, Hiroaki Kobayashi, Norio Wake, Yoshinao Oda Tags: Original Contributions Source Type: research

Prognostic evaluation of tumour type and other histopathological characteristics in advanced epithelial ovarian cancer, treated with surgery and paclitaxel/carboplatin chemotherapy: Cell type is the most useful prognostic factor
Conclusion: The proposed model of ovarian tumourigenesis does not reflect tumour behaviour in advanced disease. Tumour-cell type is the most relevant histopathological prognostic factor in advanced ovarian cancer treated with platinum/paclitaxel. (Source: European Journal of Cancer)
Source: European Journal of Cancer - November 2, 2011 Category: Cancer & Oncology Authors: A. Bamias, M. Sotiropoulou, F. Zagouri, P. Trachana, K. Sakellariou, E. Kostouros, K. Kakoyianni, A. Rodolakis, G. Vlahos, D. Haidopoulos, N. Thomakos, A. Antsaklis, M.A. Dimopoulos Tags: Gynecologic oncology Source Type: research

MicroRNA‐34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma
AbstractEndometrial serous adenocarcinoma (ESC) is aggressive and carries a poor prognosis. p53 is frequently mutated in ESC. microRNAs (miRNAs) are a direct p53 target and have been implicated in cancer cell behavior. In the present study, we compared miRNA expression levels in ESC with the levels in endometrial endometrioid adenocarcinoma (EEC) and normal endometria. Six miRNAs were identified as having aberrant downregulation specific to ESC with miR‐34b being most pronounced. miR‐34b was found to have promoter hypermethylation, which when reversed, restored miR‐34b expression in the cell lines treated with 5‐az...
Source: International Journal of Cancer - November 2, 2011 Category: Cancer & Oncology Authors: Eri HirokiFumihiko SuzukiJun‐ichi AkahiraSatoru NagaseKiyoshi ItoJunichi SugawaraYasuhiro MikiTakashi SuzukiHironobu SasanoNobuo Yaegashi Tags: Cancer Cell Biology Source Type: research

Synuclein-γ (SNCG) protein expression is associated with poor outcome in endometrial adenocarcinoma.
CONCLUSION: Overexpression of SNCG seemed to be a predictor biomarker for aggressive tumor behavior and adverse outcome in patients with endometrial cancer. Future exploration of SNCG as a potential therapeutic target for selected patients could be of interest. PMID: 22015044 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - October 18, 2011 Category: Cancer & Oncology Authors: Mhawech-Fauceglia P, Wang D, Syriac S, Godoy H, Dupupont N, Liu S, Odunsi K Tags: Gynecol Oncol Source Type: research

Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix
We report the case of a 59‐year‐old Japanese woman with cervical LCNEC combined with small cell carcinoma (SmCC). Cytologic specimens from the uterine cervix demonstrated large cells with coarse chromatin and prominent nucleoli. Frequent mitotic figures were also observed. Curettage of the uterine endometrium revealed an endometrioid adenocarcinoma with squamous differentiation; i.e., an adenoacanthoma. Histologic examination of surgically resected uterine cervical tissue revealed LCNEC with minor foci of SmCC. Neuroendocrine differentiation in LCNEC was confirmed by immunohistochemistry for synaptophysin and CD56. Cyt...
Source: Diagnostic Cytopathology - October 11, 2011 Category: Pathology Authors: Naoto Kuroda, Yukari Wada, Kaori Inoue, Masahiko Ohara, Keiko Mizuno, Makoto Toi, Azusa Tanaka, Yoji Wani, Hiroyuki Yanai Tags: Brief Report Source Type: research

Differential expression of alpha 2 macroglobulin in response to dietylstilbesterol and in ovarian carcinomas in chickens
Conclusions: Collectively, results of the present study indicate that A2M is novel estrogen-stimulated gene expressed in LE and GE of the chicken oviduct and may be used for monitoring effects of therapies for ovarian cancer in laying hens. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - October 7, 2011 Category: Endocrinology Authors: Whasun LimWooyoung JeongJi-Hye KimJin-Young LeeJinyoung KimFuller BazerJae Yong HanGwonhwa Song Source Type: research

Poorly Differentiated Ovarian Adenocarcinoma Developing in a Case of Well-Differentiated Endometrioid Carcinoma of the Contralateral Ovary
Journal of Gynecologic Surgery , Vol. 0, No. 0. (Source: Journal of Gynecologic Surgery)
Source: Journal of Gynecologic Surgery - August 30, 2011 Category: OBGYN Tags: article Source Type: research

Nuclear characteristics of the endometrial cytology: Liquid‐based versus conventional preparation
AbstractThe aim of this study was to assess the utility of liquid‐based cytologic preparation (LP) compared with conventional preparation (CP) for the assessment of nuclear findings in endometrial glandular and stromal breakdown (EGBD) which may be misdiagnosed as carcinoma in EGBD cases. The material consists of cytologic smears including 20 cases of proliferative endometrium (PE), 20 cases of EGBD, and 20 cases of endometrioid adenocarcinoma grade1 (G1) for which histopathological diagnosis was obtained by endometrial curettage at the JA Suzuka General Hospital. Nuclear findings were examined in PE cells, EGBD‐stroma...
Source: Diagnostic Cytopathology - August 26, 2011 Category: Pathology Authors: Yoshiaki Norimatsu, Yumie Shigematsu, Shingo Sakamoto, Hiroyuki Ohsaki, Kenji Yanoh, Namiki Kawanishi, Tadao K. Kobayashi Tags: Original Article Source Type: research

Endometrioid Adenocarcinoma Metastatic to the Thyroid, Presenting Like Anaplastic Thyroid Cancer
We report what we believe to be the first documented case of endometrioid adenocarcinoma metastasizing to the thyroid gland. An 80-year-old woman was referred to the otolaryngology service with a rapidly growing neck mass. The mass appeared to originate from the thyroid gland. Her clinical presentation was consistent with anaplastic thyroid carcinoma. A tracheostomy was performed. An open biopsy established the diagnosis of moderately differentiated adenocarcinoma, consistent with a gynecologic primary. The patient had undergone a hysterectomy 5 years prior for endometrioid adenocarcinoma. The thyroid tumor histology and i...
Source: Infectious Diseases in Obstetrics and Gynecology - August 15, 2011 Category: OBGYN Source Type: research

Clinicopathologic insight of simultaneously detected primary endometrial and ovarian carcinomas
Conclusions A gynecologist should always keep in mind the possibility of double primary carcinomas of the endometrium and ovary in a young, premenopausal, nulliparous woman presenting with abnormal uterine bleeding and prompt the patient for further evaluation. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-5DOI 10.1007/s00404-011-2046-zAuthors Alexandros Rodolakis, 1st Department of Obstetrics and Gynecology, Gynecologic Oncology Unit, “Alexandra” Hospital, University of Athens, 17, Eslin str., 11523 Athens, GreeceNikolaos Thomakos, 1st Department of Obstetrics and Gynecology, ...
Source: Archives of Gynecology and Obstetrics - August 14, 2011 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: research

Endometrioid Adenocarcinoma Metastatic to the Thyroid, Presenting Like Anaplastic Thyroid Cancer
We report what we believe to be the first documented case of endometrioid adenocarcinoma metastasizing to the thyroid gland. An 80-year-old woman was referred to the otolaryngology service with a rapidly growing neck mass. The mass appeared to originate from the thyroid gland. Her clinical presentation was consistent with anaplastic thyroid carcinoma. A tracheostomy was performed. An open biopsy established the diagnosis of moderately differentiated adenocarcinoma, consistent with a gynecologic primary. The patient had undergone a hysterectomy 5 years prior for endometrioid adenocarcinoma. The thyroid tumor histology and i...
Source: Journal of Cancer Epidemiology - August 11, 2011 Category: Epidemiology Source Type: research

Endometriosis and Ovarian Cancer: A Systematic Review
Conclusion. More evidence is needed before suggesting any change in the current management of endometriosis. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - July 16, 2011 Category: Allergy & Immunology Source Type: research

Hysterectomy for uterine adenocarcinoma in the elderly: Tumor characteristics, and long-term outcome.
CONCLUSION: Despite similar surgical staging and adjuvant radiation treatment, patients ≥75years old diagnosed with FIGO stage I-II uterine endometrioid carcinoma were found to have more adverse pathologic features and worse relapse-free, disease-specific and overall survival than younger patients. Age ≥75years alone may not be an independent significant prognostic factor affecting tumor recurrence. PMID: 21767871 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - July 15, 2011 Category: Cancer & Oncology Authors: Gayar OH, Robbins JR, Parikh K, Lu M, Buekers T, Munkarah A, Elshaikh MA Tags: Gynecol Oncol Source Type: research

Preoperative risk stratification using 18F-FDG PET/CT in women with endometrial cancer.
Conclusion: High-risk endometrial cancer might be differentiated by means of higher SUVmax from low-risk endometrial cancer. 18F-FDG FDG PET/CT can be applied preoperatively for stratification of risk in patients with endometrial cancer. PMID: 21727990 [PubMed - as supplied by publisher] (Source: Nuklearmedizin)
Source: Nuklearmedizin - July 4, 2011 Category: Radiology Authors: Lee HJ, Ahn BC, Hong CM, Song BI, Kim HW, Kang S, Jeong SY, Lee SW, Lee J Tags: Nuklearmedizin Source Type: research

Fascin expression in low‐grade uterine endometrioid adenocarcinoma: correlation with microcystic, elongated and fragmented (MELF)‐type alteration at the deep invasive margin
Conclusions: There are distinct micro‐anatomical variations in fascin immunoreactivity within endometrial carcinoma. The localized increase in fascin expression in MELF‐type epithelium supports the proposal that MELF changes represent areas of active tumour invasion. (Source: Histopathology)
Source: Histopathology - June 30, 2011 Category: Pathology Authors: Colin J R StewartMaxine L CrookLorella Manso Source Type: research