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What Role Does the Route of Immunization Play in the Generation of Protective Immunity against Mucosal Pathogens?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The route of vaccination is important in influencing immune responses at the initial site of pathogen invasion where protection is most effective. Immune responses required for mucosal protection can differ vastly depending on the individual pathogen. For some mucosal pathogens, including acute self-limiting infections, high-titer neutralizing Abs that enter tissue parenchyma or transude into the mucosal lumen are sufficient for clearing cell-free virus. However, for pathogens causing chronic infections such as HIV, hepatitis C virus, herpes viruses, mycobacteria, and fungal and parasitic infections, a single arm of th...
Source: Journal of Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Belyakov IM, Ahlers JD Tags: J Immunol Source Type: journals

Primary antiphospholipid syndrome and hepatitis B and C infectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A small percentage of patients with primary APS had positive serology for hepatitis B and C, and all represented cases post-vaccine or serology scar. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals

GAVI Alliance Drives Down Pentavalent Vaccine Costs, Data ShowsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The "co-ordinated buying policy" of the GAVI Alliance has driven down "[t]he price of a vaccine that helps babies fight off killer diseases," according to data released by the group, Reuters reports. In 2010, the price of pentavalent vaccine, which protects against Hib (Haemophilus influenzae type b), diphtheria, whooping cough, tetanus and hepatitis B, will fall "below $3.0 - a drop of almost $0. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Immune System / vaccines Source Type: news

GAVI Alliance Drives Down Pentavalent Vaccine Costs, Data ShowsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The "co-ordinated buying policy" of the GAVI Alliance has driven down "[t]he price of a vaccine that helps babies fight off killer diseases," according to data released by the group, Reuters reports. In 2010, the price of pentavalent vaccine, which protects against Hib (Haemophilus influenzae type b), diphtheria, whooping cough, tetanus and hepatitis B, will fall "below $3.0 - a drop of almost $0. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Immune System / vaccines Source Type: news

Hepatitis B markers and vaccination-induced protection rate among Albanian pregnant women in Greece.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatitis B has long been a serious public health problem both in Greece and in Albania. In the February 2009 issue of World Journal of Gastroenterology, Resuli et al presented the interesting epidemiological data concerning hepatitis B virus infection in Albania. The results of this study were discussed and several data from our similar research were provided. PMID: 19916183 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Elefsiniotis IS, Vezali E, Brokalaki H, Tsoumakas K Tags: World J Gastroenterol Source Type: journals

Introduction of human papillomavirus (HPV) vaccination in Belgium, 2007-2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper documents the progress of human papillomavirus (HPV) vaccine introduction in Belgium. Information on vaccine use is based on sales statistics and reimbursement claims. From November 2007 to November 2008, the National Institute for Health and Disability Insurance reimbursed the HPV vaccine for girls aged between 12-15 years. In December 2008, the age limit was extended to include girls up to the age of 18. In November 2008, the total number of HPV vaccines sold exceeded 530,000 doses. The number of vaccines reimbursed in Belgium, for the period November 2007-November 2008, corresponds to the amount required to f...
Source: Eurosurveillance latest news - November 19, 2009 Category: Infectious Diseases Source Type: journals

Swine flu vaccine uptakeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several newspapers have reported that pregnant women and other vulnerable people are refusing to have the swine flu vaccine. The Times reported that a poll of GPs found that only 46% of people who were offered the vaccine have accepted it, and one doctor estimated that only 5% of pregnant women have had it. The news reports are based on a “snapshot” survey of 107 GPs. The survey asked how likely they were to hit the government’s target of vaccinating at least half of their patients who are under 65 and in high-risk groups this winter. GPs were also asked to estimate how many of the people who were offered the vacci...
Source: NHS News Feed - November 18, 2009 Category: Consumer Health News Tags: Swine flu Source Type: news

Targeting TGF-[beta]1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intestinal fibrosis and stricture formation are major complications of inflammatory bowel disease (IBD), for which there are currently few effective treatments. We sought to investigate whether targeting transforming growth factor-beta1 (TGF-[beta]1), a key profibrotic mediator, with a peptide-based virus-like particle vaccine would be effective in suppressing intestinal fibrosis by using a mouse model of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced chronic colitis.The vaccine was prepared by inserting a peptide derived from mouse TGF-[beta]1 into a carrier hepatitis B core antigen using gene recombination methods. C...
Source: Inflammatory Bowel Diseases - November 18, 2009 Category: Gastroenterology Authors: Yanbing Ma, Qingdong Guan, Aiping Bai, Carolyn R. Weiss, China-Li Hillman, Allan Ma, Gang Zhou, Gefei Qing, Zhikang Peng Source Type: journals

Viruses within the Flaviviridae Decrease CD4 Expression and Inhibit HIV Replication in Human CD4+ Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Viral infections alter host cell homeostasis and this may lead to immune evasion and/or interfere with the replication of other microbes in coinfected hosts. Two flaviviruses are associated with a reduction in HIV replication or improved survival in HIV-infected people (dengue virus (DV) and GB virus type C (GBV-C)). GBV-C infection and expression of the GBV-C nonstructural protein 5A (NS5A) and the DV NS5 protein in CD4(+) T cells inhibit HIV replication in vitro. To determine whether the inhibitory effect on HIV replication is conserved among other flaviviruses and to characterize mechanism(s) of HIV inhibition, the ...
Source: Journal of Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Xiang J, McLinden JH, Rydze RA, Chang Q, Kaufman TM, Klinzman D, Stapleton JT Tags: J Immunol Source Type: journals

Hepatitis A vaccine/yellow fever vaccine: Autoimmune hepatitis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 16, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Generation of infectious and pathogenic Duck Hepatitis Virus Type 1 from cloned full-length cDNA.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A full-length cDNA clone of duck hepatitis virus type 1 (DHV-1) isolated from duck was assembled in the plasmid vector pBluescript II SK+. RNA synthesized in vitro by means of a Sp6 promoter inserted in front of the cDNA produced infectious particles after transfection of BHK-21 cells, as shown by the appearance of cytopathic effect. The rescued virus was also found to be highly pathogenic to young ducks by intradermal injection and resulted in a fatal disease indistinguishable from that of wild-type virus. The availability of the first cDNA clone of DHV-1 will allow examination of the molecular mechanisms behind DHV-1...
Source: Virus Research - November 14, 2009 Category: Virology Authors: Yun T, Ni Z, Liu GQ, Yu B, Chen L, Huang JG, Zhang YM, Chen JP Tags: Virus Res Source Type: journals

PEDIARIX (Diphtheria And Tetanus Toxoids And Acellular Pertussis Adsorbed, Hepatitis B (Recombinant) And Inactivated Poliovirus Vaccine Combined) Injection, Suspension [GlaxoSmithKline Biologicals SA]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 12, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 12, 2009 Category: Drugs & Pharmacology Source Type: organizations

Invited Commentary: Evaluating Vaccination Programs Using Genetic Sequence Data.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genomic data will become an increasingly important component of epidemiologic studies in coming years. The authors of the accompanying Journal article, van Ballegooijen et al. (Am J Epidemiol. 2009;XXX(XX):000-000), are to be commended for attempting to use the coalescent analysis of viral sequence data to evaluate a hepatitis B vaccination program. Coalescent theory attempts to link the phylogenetic history of populations with rates of population growth and decline. In particular, under certain assumptions, a reduction in genetic diversity can be interpreted as a reduction in disease incidence. However, the authors of...
Source: Am J Epidemiol - November 12, 2009 Category: Epidemiology Authors: Halloran ME, Holmes EC Tags: Am J Epidemiol Source Type: journals

Molecular Sequence Data of Hepatitis B Virus and Genetic Diversity After Vaccination.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effect of vaccination programs on transmission of infectious disease is usually assessed by monitoring programs that rely on notifications of symptomatic illness. For monitoring of infectious diseases with a high proportion of asymptomatic cases or a low reporting rate, molecular sequence data combined with modern coalescent-based techniques offer a complementary tool to assess transmission. Here, the authors investigate the added value of using viral sequence data to monitor a vaccination program that was started in 1998 and was targeted against hepatitis B virus in men who have sex with men in Amsterdam, the Neth...
Source: Am J Epidemiol - November 12, 2009 Category: Epidemiology Authors: van Ballegooijen WM, van Houdt R, Bruisten SM, Boot HJ, Coutinho RA, Wallinga J Tags: Am J Epidemiol Source Type: journals

A mathematical model to study the effect of hepatitis B virus vaccine and antivirus treatment among the Canadian Inuit populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study will use a mathematical model to compare the roles of vaccination and therapy to predict future prevalence and incidence among the Canadian Inuit population for the next 50 years. We applied a mathematical model developed by Medley et al. (Nat Med 7(5):619–624, 2001), combined with data on hepatitis B incidence, prevalence, and vaccination coverage, to predict trends of hepatitis B virus (HBV) among the Inuit population over the next 50 years. The current estimated prevalence of HBV is 6.04% and the incidence is 3.4/100,000 persons among Canadian Inuit. If HBV vaccination coverage levels of 47.2...
Source: European Journal of Clinical Microbiology & Infectious Diseases - November 11, 2009 Category: Microbiology Tags: European Journal of Clinical Microbiology & Infectious Diseases Source Type: journals

Management of Hepatitis B Virus Reactivation in Patients with Hematological Malignancies Treated with ChemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Essential to the management of patients with hematological malignancies undergoing chemotherapy are surveillance and prophylaxis of HBV infection together with prompt administration of nucleoside/nucleotide analogs in cases of reactivation and/or seroreversion. Content Type Journal ArticleCategory Brief ReportDOI 10.1007/s15010-009-9019-1Authors D. Francisci, University of Perugia Division of Infectious Diseases, Dept. of Experimental Medicine and Biochemical Science Ospedale “Santa Maria della Misericordia”, P.zzle Menghini 1 06132 Perugia ItalyF. Falcinelli, University of Perugia Sect...
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

Health News of the DayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day:How long does hepatitis B vaccine protection last? More than 2 decades http://bit.ly/4lhMlHLarge trials required to clarify whether sodium bicarbonate has value for prevention of contrast-induced nephropathy http://bit.ly/yOE45List of Medical Journal Feeds Arranged by Topic - the University of Wisconsin http://bit.ly/4zxxdgNYT interviews researcher behind Gleevec for CML, "converting a fatal cancer into a manageable chronic ...
Source: Clinical Cases and Images - November 3, 2009 Category: Journals (General) Tags: Health News of the Day Source Type: info

ProQuadEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Approval Letter and Approved Final Draft Labeling for Merck's Efficacy Supplement for Measles, Mumps, Rubella, and Varicella Vaccine, Live, (ProQuad®), to include concomitant administration with hepatitis A vaccine (VAQTA®) and/or pneumococcal conjugate vaccine (Prevnar®), use of ProQuad® in children 15 months to 12 years of age if a second dose of measles, mumps, rubella, and varicella is needed, additional safety data after a first or second dose of ProQuad®, and to comply with the Physician’s Labeling Rule format, have been issued. (Source: What's New at CBER)
Source: What's New at CBER - November 3, 2009 Category: Biomedical Science Source Type: organizations

How long does hepatitis B vaccine protection last?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW YORK (Reuters Health) - The hepatitis B vaccine - given to protect against infection by a virus that can cause severe liver damage and cancer - may protect for more than two decades, according to a new study. (Source: Reuters: Health)
Source: Reuters: Health - November 2, 2009 Category: Consumer Health News Tags: healthNews Source Type: news

How Long Does Hepatitis B Vaccine Protection Last?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The hepatitis B vaccine - given to protect against infection by a virus that can cause severe liver damage and cancer - may protect for more than two decades, according to a new study. Source: Reuters Health Related MedlinePlus Topics: Childhood Immunization, Hepatitis B (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - November 2, 2009 Category: Consumer Health News Source Type: consumer

Non-Response to HBV Vaccine a Sign of Possible Celiac DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Celiac disease patients often don't respond to hepatitis B virus (HBV) vaccination, leading Italian researchers to recommend that monitoring responses to the vaccine be routine in celiac patients. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 2, 2009 Category: Consumer Health News Tags: Allergy & Clinical Immunology Source Type: news

GlobeImmune's Hepatitis C Therapeutic Vaccine Combined with Standard of Care Increases End of Treatment Response Rate by 15%Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Phase 2b Data Presented at American Association for the Study of Liver Diseases Meeting LOUISVILLE, Colo., Nov. 2, 2009 - GlobeImmune Inc. will present Phase 2b data today at the 60th Annual Meeting of the American Association for the Study of Liver... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - November 2, 2009 Category: Pharmaceuticals Source Type: clinical trials

Prevalence of hepatitis B and C and risk factors for nonvaccination in inflammatory bowel disease patients in Northeast FranceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Data regarding the prevalence of hepatitis C (HCV) and hepatitis B (HBV) in inflammatory bowel disease (IBD) patients are conflicting.In all, 315 IBD (252 Crohn's disease [CD] and 63 ulcerative colitis [UC]) patients were consecutively recruited between June 2005 and May 2009.The median age was 33 years (interquartile range [IQR]: 24-43) and median disease duration was 5 years (IQR: 2-11). Present and/or past HBV and HCV infection was found in 2.86% of 315 patients (CD: HBsAg 0.79%, anti-HBc 2.78%, anti-HCV 0.79%; UC: HBsAg 1.59%, anti-HBc 1.59%, anti-HCV 1.59%). Effective vaccination (anti-HBs without anti-HBc) was presen...
Source: Inflammatory Bowel Diseases - November 2, 2009 Category: Gastroenterology Authors: Jean-Baptiste Chevaux, Abdelbasset Nani, Abderrahim Oussalah, Véronique Venard, Mouni Bensenane, Arthur Belle, Jean-Louis Gueant, Marc-André Bigard, Jean-Pierre Bronowicki, Laurent Peyrin-Biroulet Source Type: journals

HBV-specific T-cell responses in healthy seronegative sexual partners of patients with chronic HBV infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary. The hepatitis B virus (HBV) is frequently transmitted by sexual intercourse. Thus, HBV-guidelines recommend vaccination. However, we have identified healthy hepatitis B surface antigen and anti-HBc-negative unvaccinated sexual partners of patients with chronic hepatitis B. We investigated whether HBV-specific cellular immune responses were present that could explain the apparent protection against HBV infection. In six anti-HBc-negative HBV-exposed sexual partners, HBV-specific T-cell responses were studied by proliferation assay and cytometric bead array after stimulation with 74 overlapping peptides spanning the...
Source: Journal of Viral Hepatitis - November 2, 2009 Category: Infectious Diseases Authors: J. Wiegand, S. Meya, V. Schlaphoff, M. P. Manns, J. Mössner, H. Wedemeyer, H. L. Tillmann Source Type: journals

Infection in the foetus and neonateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Neonates, particularly when premature, are relatively immunocompromised and are therefore prone to more infections, more severe disease, and infection with unusual organisms. Almost all foetal and many neonatal infections are caused by organisms acquired from the mother. Transmission may be transplacental in utero, perinatal during the birth process or postnatal. Neonates can also acquire infections horizontally. This review provides an overview of the epidemiology, clinical features, diagnosis, prevention and treatment of infections in the foetus and neonate with updates on new developments including the identif...
Source: Medicine - November 1, 2009 Category: Internal Medicine Authors: Shunmay Yeung, Julia M. Kenny Tags: Foetal infections Source Type: journals

Vaccines as a trigger for myopathies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vaccines are considered to be among the greatest medical discoveries, credited with the virtual eradication of some diseases and the consequent improved survival and quality of life of the at-risk population. With that, vaccines are among the environmental factors implicated as triggers for the development of inflammatory myopathies. The sporadic reports on vaccine-induced inflammatory myopathies include cases of hepatitis B virus, bacillus Calmette-Guérin, tetanus, influenza, smallpox, polio, diphtheria, diphtheria-pertussis-tetanus, combination of diphtheria with scarlet fever and diphtheria-pertussis-tetanus wi...
Source: Lupus - November 1, 2009 Category: Rheumatology Authors: Orbach H, Tanay A Tags: Lupus Source Type: journals

Transverse myelitis and vaccines: a multi-analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transverse myelitis is a rare clinical syndrome in which an immune-mediated process causes neural injury to the spinal cord. The pathogenesis of transverse myelitis is mostly of an autoimmune nature, triggered by various environmental factors, including vaccination. Our aim here was to search for and analyze reported cases of transverse myelitis following vaccination. A systematic review of PubMed, EMBASE and DynaMed for all English-language journals published between 1970 and 2009 was preformed, utilizing the key words transverse myelitis, myelitis, vaccines, post-vaccination, vaccination and autoimmunity. We have dis...
Source: Lupus - November 1, 2009 Category: Rheumatology Authors: Agmon-Levin N, Kivity S, Szyper-Kravitz M, Shoenfeld Y Tags: Lupus Source Type: journals

Ten cases of systemic lupus erythematosus related to hepatitis B vaccine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this article is to identify common and atypical features of systemic lupus erythematosus diagnosed following hepatitis B vaccination. We analyzed retrospectively the medical records of 10 systemic lupus erythematosus patients from different centers, who developed the disease following hepatitis B vaccination and determined the prevalence of different manifestations and the time association to vaccination. In this case series, 80% of the patients were female, mean age 35 +/- 9 years, of which 20% received one inoculation, 20% received two doses and 60% received all three inoculations. The mean latency perio...
Source: Lupus - November 1, 2009 Category: Rheumatology Authors: Agmon-Levin N, Zafrir Y, Paz Z, Shilton T, Zandman-Goddard G, Shoenfeld Y Tags: Lupus Source Type: journals

Epidemiology of hepatitis a virus infections, Germany, 2007-2008.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Approximately 60% of hepatitis A virus infections in Germany occur in persons without a travel history to disease-endemic areas and for whom sources of infection are unknown. Recommendation of pretravel vaccination fails to prevent the remaining imported infections. Using enhanced surveillance in 2007-2008, we analyzed epidemiologic patterns of hepatitis A in Germany and appropriateness and adequacy of current immunization recommendations. Young patients with a migration background who had visited friends and family in their ancestral countries accounted for most imported cases. Phylogenetic analysis showed high divers...
Source: Emerging Infectious Diseases - November 1, 2009 Category: Infectious Diseases Authors: Faber MS, Stark K, Behnke SC, Schreier E, Frank C Tags: Emerg Infect Dis Source Type: journals

Profit Drive Swine Flu Propaganda - Pump Up the Volume - Part VIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article is part five in a six-part series. Be sure to read part five at http://www.naturalnews.com/027363_autism_vaccines_swine_flu.htmlMost American are unaware that flu vaccines still contain thimerosal and that to avoid mercury, they have to ask for mercury-free shots. On November 13, 2007, the Milwaukee Journal Sentinel ran the headline: "Most flu shots contain mercury, but few know it."Thimerosal consists of 49.6% ethyl mercury. The Environmental Protection Agency and Food and Drug Administration have not set an exposure limit for ethyl mercury."The federal agencies have, however, set exposure limits for another ...
Source: NaturalNews.com - October 31, 2009 Category: Consumer Health Advice Source Type: news

Coverage of and influences on timely administration of hepatitis B vaccine birth dose in remote rural areas of the People's Republic of China.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A survey was conducted in 2006 to assess the coverage and timeliness of the birth dose of hepatitis B vaccine (HepB(1)) and related influences among children in rural areas of Guangxi, Guizhou, Tibet, and Shaanxi provinces, People's Republic of China. A total of 3,390 children born in 2004 were surveyed in four counties in each province, where a project to strengthen routine immunization is being implemented by the China Ministry of Health, supported by the United National Children's Fund. Two-stage stratified cluster sampling was undertaken to select those surveyed. A questionnaire was administered to parents or guard...
Source: Rural Remote Health - October 30, 2009 Category: Rural Health Authors: Zhou Y, Wang H, Zheng J, Zhu X, Xia W, Hipgrave DB Tags: Am J Trop Med Hyg Source Type: journals

Construction of HCV-polytope vaccine candidates harbouring immune-enhancer sequences and primary evaluation of their immunogenicity in BALB/c miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract An efficient vaccine against hepatitis-C virus (HCV) infection requires vigorous and focused CD8+ T-cell responses against viral antigens. Due to immunosuppressive effect of HCV antigens, polytope vaccines comprising the minimal CD8+CTL epitopes are of peculiar concern. Herein, to provide information for construction of efficient HCV polytope vaccine candidates, one H-2Dd (E2405–414:E2) and two HLA-A*0201 (E1363–372:E1 and Core35-44:C)-restricted CD8+ T-cell epitopes of HCV were selected. By employing number of in silico analyses, the E2E1C linear format was predicted as optimum epitope consecutio...
Source: Virus Genes - October 30, 2009 Category: Genetics & Stem Cells Tags: Virus Genes Source Type: journals

Pediarix (Diphtheria, Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B and Inactivated Poliovirus Vaccine) - updated on RxListEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pediarix (Diphtheria, Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B and Inactivated Poliovirus Vaccine) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 29, 2009 Category: Drugs & Pharmacology Source Type: consumer

Engerix-B (Hepatitis B Vaccine Recombinant) - updated on RxListEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Engerix-B (Hepatitis B Vaccine Recombinant) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 29, 2009 Category: Drugs & Pharmacology Source Type: consumer

Nabi-HB (Hepatitis B Vaccine Recombinant) - updated on RxListEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nabi-HB (Hepatitis B Vaccine Recombinant) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 29, 2009 Category: Drugs & Pharmacology Source Type: consumer

Bloodborne virus infections among drug users in Ireland: a retrospective cross-sectional survey of screening, prevalence, incidence and hepatitis B immunisation uptakeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The proportion of clients screened for HCV, HBV and HIV infection has increased since the introduction of a screening protocol in 1998. Targeted vaccination for opiate users against hepatitis B is more successful than previously shown in Ireland. The prevalence and incidence of bloodborne viruses remains high among opiate users attending addiction treatment services, despite an increase in availability of harm reduction interventions. Content Type Journal ArticleCategory Original PapersDOI 10.1007/BF03169123Authors L. Grogan, Bridge House, Cherry Orchard Hospital Addiction Services Dublin ...
Source: Irish Journal of Medical Science - October 28, 2009 Category: Journals (General) Tags: Irish Journal of Medical Science Source Type: journals

Immunization with a DNA vaccine candidate in chronic hepatitis C patients is safe, well tolerated and does not impair immune response induction after anti-hepatitis B vaccinationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the present study, we evaluated the safety of CIGB-230, a novel vaccine candidate based on the mixture of a plasmid for DNA immunization, expressing hepatitis C virus (HCV) structural antigens, with a recombinant HCV Core protein.Fifteen HCV chronically-infected volunteers with detectable levels of HCV RNA genotype 1b, who were nonresponders to previous treatment with interferon plus ribavirin, were intramuscularly injected with CIGB-230 on weeks 0, 4, 8, 12, 16 and 20. Individuals were also immunized at weeks 28, 32 and 36 with a recombinant vaccine against hepatitis B. Adverse events were recorded and analyzed. Blood ...
Source: The Journal of Gene Medicine - October 28, 2009 Category: Genetics & Stem Cells Authors: Marlen Castellanos, Zurina Cinza, Zaily Dorta, Gloria Veliz, Héctor Vega, Irma Lorenzo, Sergio Ojeda, Santiago Dueñas-Carrera, Liz Alvarez-Lajonchere, Gillian Martínez, Elena Ferrer, Miladys Limonta, Marbelis Linares, Odalis Ruiz, Boris Acevedo, Dinora Source Type: journals

Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite the existence of effective vaccines, HBV infection remains a major health problem with 2 billion people infected worldwide. Among them, 350 million are chronically infected, a major risk factor for the development of hepatocellular carcinoma (HCC). There is a strong need to develop new and efficient treatments against chronic infection and HCC. It is therefore important to understand HBV replication and persistence as well as the role of HBV in liver carcinogenesis. This chapter focuses on the regulatory protein HBx which is thought to play a central role in HBV regulation and pathogenesis. HBx has been shown t...
Source: Advances in Cancer Research - October 27, 2009 Category: Cancer & Oncology Authors: Benhenda S, Cougot D, Buendia MA, Neuveut C Tags: Adv Cancer Res Source Type: journals

Hepatitis b vaccine and the risk of cns inflammatory demyelination in childhoodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - October 26, 2009 Category: Neurology Authors: Lievre, M., Members of the Epidemiology Working Group of the French Pharmacovigilance Commission, Costagliola, D., Evans, S., Fourrier, A., Imbs, J. -L., Levy-Bruhl, D., Merle, L., Micallef, J., Oger, E. Tags: CORRESPONDENCE Source Type: journals

Vaccination Program Cuts HBV Infection in Children of Foreign-Born Asian ParentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The hepatitis B virus (HBV) infant vaccination program in the US appears to have reduced chronic infection, morbidity and mortality among populations at high risk, a paper in the October 9th issue of the journal Vaccine suggests. Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - October 26, 2009 Category: Gastroenterology Tags: Allergy & Clinical Immunology Source Type: info

What Problems Do I Need to Screen This New International Adoptee or Domestic Foster Care Child For?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion There is much overlap between immigrant children and children in foster care - particularly around adoption. Immigrant children are defined as those who are legal and undocumented immigrants, refugees and international adoptees. Children in domestic foster care if not reunified with their parents may be adopted by relatives (kinship permanency) or with non-relatives (national adoptees). Additionally, international adoptees and children initially or recently placed into foster care need similar medical evaluations. Children that are adopted, including those who had been in foster care, have higher rates of asthm...
Source: PediatricEducation.org - October 26, 2009 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: info

Pediatric Hepatitis B Vaccination Has Lasting EffectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Booster doses of hepatitis B vaccine up to 10 years after the original pre-adolescent vaccination prompt a robust hepatitis B virus surface antibody (anti-HBs) response in almost all recipients, Canadian researchers report in the October issue of Vaccine. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 23, 2009 Category: Consumer Health News Tags: Allergy & Clinical Immunology Source Type: news

Hepatitis B immunization coverage and risk behaviour among Danish travellers: Are immunization strategies based on single journey itineraries rational?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The rationale and efficacy of current immunization strategies are challenged. Based on the results presented here and the availability of vaccines with long-lasting coverage, the authors find that recommendations of immunization should be based on lifetime risk instead of single journey itineraries. The authors find that a recommendation and/or cost-benefit discussion would be relevant in the pre-travel counselling of most – especially younger – travellers to endemic areas. (Source: Journal of Infection)
Source: Journal of Infection - October 23, 2009 Category: Infectious Diseases Authors: Ulla Schierup Nielsen, Eskild Petersen, Carsten Schade Larsen Tags: Original Articles Source Type: journals

[Vaccination rate of premature infants at 6 and 24 months of age: A pilot study.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The vaccine practices do not follow the postnatal chronological age of the premature baby according to the schedule recommended for full-term infants and vaccination is begun late. Based on the CSHPF vaccination recommendations, nearly 7 premature infants out of 10 have an incomplete immunization status for DTPCoqHib, hepatitis B, and ROR at 2 years of age. According to the pertussis coverage observed in premature infants, the new recommendations on vaccination of the newborn's care giver and family should be completed before the infant's discharge from the hospital using a new acellular vaccine for adult immun...
Source: Archives de Pediatrie - October 23, 2009 Category: Pediatrics Authors: Pinquier D, Adde-Michela C, Ploin D, Levêque C, Marret S, Tags: Arch Pediatr Source Type: journals

Lichen planus in childhood: report of 100 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. Vaccination against hepatitis B has been suggested to be causally related to the onset of LP in various published studies. However, only 16 of our patients had been vaccinated against hepatitis B. If there is a causal relationship, more cases of LP in children may occur in the future, as vaccination against hepatitis B becomes routine in India. (Source: Clinical And Experimental Dermatology)
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: A. J. Kanwar, D. De Source Type: journals

Intramuscular or Intradermal Hepatitis B Vaccine Administration in Hemodialysis Patients?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In prevalent hemodialysis (HD) patients nonresponsive to a primary vaccination series, Barraclough et al detected greater seroconversion rates with revaccination using intradermal (ID) administration of 5 μg of hepatitis B virus vaccine every week for 8 weeks (79%) in comparison to intramuscular (IM) administration of 40 μg of vaccine at weeks 1 and 8 (40%). (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - October 22, 2009 Category: Urology & Nephrology Authors: Regina H. Medeiros, Ana E. Figueiredo, Carlos E. Poli de Figueiredo, Domingos d'Avila, C. Abaeté de los Santos Tags: Correspondence Source Type: journals

In Reply to ‘Intramuscular or Intradermal Hepatitis B Vaccine Administration in Hemodialysis Patients?’Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Medeiros et al contrast their data showing markedly lower seroconversion rates with intradermal (ID) compared with intramuscular (IM) hepatitis B virus vaccination with results from our trial despite differences in study populations and trial methods. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - October 22, 2009 Category: Urology & Nephrology Authors: Katherine A. Barraclough, Carmel M. Hawley, E. Geoffrey Playford Tags: Correspondence Source Type: journals

Worldwide Vaccine Availability Reaches All-Time High: ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Worldwide Vaccine Availability Reaches All-Time High: ReportCategory: Health NewsCreated: 10/21/2009 12:10:00 PMLast Editorial Review: 10/22/2009 (Source: MedicineNet Hepatitis C General)
Source: MedicineNet Hepatitis C General - October 22, 2009 Category: Infectious Diseases Source Type: consumer

M2e-based universal influenza A vaccine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human influenza causes substantial morbidity and mortality. Currently, licensed influenza vaccines offer satisfactory protection if they match the infecting strain, but they come with significant drawbacks. These vaccines are derived from prototype viruses, containing the hemagglutinin of influenza viruses that are likely to cause the next epidemic. Their usefulness against a future pandemic, however, remains problematic. A vaccine based on the ectodomain of influenza matrix protein 2 (M2e) could overcome these drawbacks. M2e is highly conserved in both human and avian influenza A viruses. The low immunogenicity agains...
Source: Vaccine - October 22, 2009 Category: Allergy & Immunology Authors: Fiers W, De Filette M, Bakkouri KE, Schepens B, Roose K, Schotsaert M, Birkett A, Saelens X Tags: vaccine Source Type: journals

Current issues in the management of paediatric viral hepatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Viral hepatitis poses important problems for children. In preschoolers, hepatitis A virus (HAV) infection frequently causes acute liver failure. Vaccinating toddlers against HAV in countries with high endemicity is expected to decrease mortality. HAV vaccine demonstrates efficacy (comparable to immunoglobulin) as post-exposure prophylaxis. A recently developed vaccine against hepatitis E virus (HEV) may benefit fetal health, because pregnant women are most prone to acute liver failure as a result of HEV. Hepatitis B vaccine continues to demonstrate value and versatility for preventing serious liver disease. With chronic in...
Source: Liver International - October 18, 2009 Category: Gastroenterology Authors: Latifa T. F. Yeung, Eve A. Roberts Source Type: journals