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This page shows you the latest news and research items in this category.

Neurobiological insight into hyperbaric hyperoxia
ConclusionsThe present study firstly confirmed the rCBF distribution increase during HBO in sensory‐motor and visual cortices and it showed for the first time a higher perfusion tracer distribution in areas encompassed in dorsal attention system and in default mode network. These findings unfold both the externally directed cognition performance improvement related to the HBO and the internally directed cognition states during resting state conditions, suggesting possible beneficial effects in TBI and stroke patients.This article is protected by copyright. All rights reserved. (Source: Acta Physiologica)
Source: Acta Physiologica - May 21, 2013 Category: Physiology Authors: Alessandro Micarelli, Hans Jacobsson, Stig A Larsson, Cathrine Jonsson, Marco Pagani Tags: Regular Paper Source Type: research

Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats
In conclusion, acute oral administration of BD-AcAc2 produced sustained ketosis and significantly delayed CNS-OT seizures by elevating AcAc and acetone. (Source: AJP: Regulatory, Integrative and Comparative Physiology)
Source: AJP: Regulatory, Integrative and Comparative Physiology - May 15, 2013 Category: Physiology Authors: D'Agostino, D. P., Pilla, R., Held, H. E., Landon, C. S., Puchowicz, M., Brunengraber, H., Ari, C., Arnold, P., Dean, J. B. Tags: Obesity, Diabetes and Energy Homeostasis Source Type: research

The Center for Wound Healing, Inc. Changes Name to RestorixHealth(R)
The Center for Wound Healing, Inc. has changed its name to RestorixHealth, giving further distinction to their expertise in developing and managing comprehensive wound care centers of excellence Tarrytown, NY--(Healthcare Sales & Marketing Network)--The... Devices, Wound CareRestorixHealth, Center for Wound Healing, hyperbaric oxygen (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 1, 2013 Category: Pharmaceuticals Source Type: news

Complementary and alternative medicine for autism spectrum disorders: Rationale, safety and efficacy
Abstract Complementary and alternative medicine is widely used for children with autism spectrum disorder, despite uncertainty regarding efficacy. This review describes complementary and alternative practices commonly used among this population, the rationale for the use of each practice, as well as the side‐effect profile and evidence for efficacy. The existing evidence base indicates that melatonin can be recommended as a treatment for sleeping disturbances associated with autism spectrum disorder, while secretin can be rejected as an efficacious treatment for broader autistic symptoms. There is insufficient evidence t...
Source: Journal of Paediatrics and Child Health - May 1, 2013 Category: Pediatrics Authors: Andrew JO Whitehouse Tags: Review Article Source Type: research

Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats.
In conclusion, acute oral administration of BD-AcAc2 produced sustained ketosis and significantly delayed CNS-OT seizures by elevating AcAc and acetone. PMID: 23552496 [PubMed - in process] (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - May 1, 2013 Category: Physiology Authors: D'Agostino DP, Pilla R, Held HE, Landon CS, Puchowicz M, Brunengraber H, Ari C, Arnold P, Dean JB Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Inhalation injury: epidemiology, pathology, treatment strategies
Lung injury resulting from inhalation of smoke or chemical products of combustion continues to be associated with significant morbidity and mortality. Combined with cutaneous burns, inhalation injury increases fluid resuscitation requirements, incidence of pulmonary complications and overall mortality of thermal injury. While many products and techniques have been developed to manage cutaneous thermal trauma, relatively few diagnosis-specific therapeutic options have been identified for patients with inhalation injury. Several factors explain slower progress for improvement in management of patients with inhalation injury....
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - April 19, 2013 Category: Emergency Medicine Authors: David DriesFrederick Endorf Source Type: research

A potential early physiological marker for CNS oxygen toxicity: hyperoxic hyperpnea precedes seizure in unanesthetized rats breathing hyperbaric oxygen
Hyperbaric oxygen (HBO2) stimulates presumptive central CO2-chemoreceptor neurons, increases minute ventilation (Vmin), decreases heart rate (HR) and, if breathed sufficiently long, produces central nervous system oxygen toxicity (CNS-OT; i.e., seizures). The risk of seizures when breathing HBO2 is variable between individuals and its onset is difficult to predict. We have tested the hypothesis that a predictable pattern of cardiorespiration precedes an impending seizure when breathing HBO2. To test this hypothesis, 27 adult male Sprague-Dawley rats were implanted with radiotelemetry transmitters to assess diaphragmatic/ab...
Source: Journal of Applied Physiology - April 15, 2013 Category: Physiology Authors: Pilla, R., Landon, C. S., Dean, J. B. Tags: ARTICLES Source Type: research

Effect of hyperbaric oxygenation on intervertebral disc degeneration: An in vivo study with Sprague-Dawley rats. Wang IC, Liu HT, Yu CM, et al. Spine (Phila Pa 1976) 2013 Feb 1;38(3):E137–42
An in vivo study was conducted to test the effect of hyperbaric oxygenation (HBO) on intervertebral disc degeneration in Sprague-Dawley rats. To observe the changes in intervertebral disc height and levels of glycosaminoglycan, collagen, interleukin-1β (IL-1β), prostaglandin E2 (PGE2), and inducible nitric oxide synthase (iNOS) in degenerated intervertebral discs after HBO therapy. (Source: The Spine Journal)
Source: The Spine Journal - April 1, 2013 Category: Orthopaedics Tags: Journal Reports Source Type: research

Phase II Clinical Trial Of Combined HBO2/NBH Treatment For Severe Traumatic Brain Injury
Researchers at the Hennepin County Medical Center, University of Minnesota, and Minneapolis Medical Research Foundation (Minneapolis, Minnesota) report that the combined use of hyperbaric oxygen and normobaric hyperoxia therapies provides better outcomes in patients with severe traumatic brain injury (TBI) than the standard intensive neurosurgical care recommended for this injury... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 20, 2013 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography.
Abstract Isopenicillin N synthase (IPNS) converts the linear tripeptide δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (ACV) into bicyclic isopenicillin N (IPN) in the central step in the biosynthesis of penicillin and cephalosporin antibiotics. Solution-phase incubation experiments have shown that IPNS turns over analogues with a diverse range of side chains in the third (valinyl) position of the substrate, but copes less well with changes in the second (cysteinyl) residue. IPNS thus converts the homologated tripeptides δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-valine (AhCV) and δ-(L-α-aminoadipoyl)-L-homocysteinyl-...
Source: Chembiochem - March 18, 2013 Category: Biochemistry Authors: Daruzzaman A, Clifton IJ, Adlington RM, Baldwin JE, Rutledge PJ Tags: Chembiochem Source Type: research

Factor V Leiden Mutation-Related Chronic Skin Ulcers
Chronic skin ulcers require extensive, systemic differential diagnosis; thus, they are difficult to diagnose and treat. Transient or persistent hypercoagulable states are among the rare causes of skin ulcers. Here, we present the case of a 27-year-old woman patient with recurrent, nonhealing skin ulcers of 8 years’ duration, who had been treated unsuccessfully with various medications under different diagnoses at different clinics. On admission, a skin biopsy demonstrated occlusive vasculopathy, and the search for an inherited hypercoagulable state revealed a heterozygous factor V Leiden mutation. The patient was tre...
Source: The International Journal of Lower Extremity Wounds - March 15, 2013 Category: Surgery Authors: Kayatas, K., Cebeci, F., Karatoprak, C., Benzer, M., Demirtunc, R., Demirkesen, C. Tags: Case Report Source Type: research

Hyperbaric oxygen treatment therapy
(Source: Annals of Neurology)
Source: Annals of Neurology - March 8, 2013 Category: Neurology Authors: Pierre Marois MD Tags: Letter to the Editor Source Type: research

American Brachytherapy Society–Groupe Européen de Curiethérapie–European Society of Therapeutic Radiation Oncology (ABS-GEC-ESTRO) consensus statement for penile brachytherapy
Conclusions: The good tumor control rates, acceptable morbidity, and functional organ preservation warrant recommendation of brachytherapy as the initial treatment for invasive T1, T2, and selected T3 penile cancers. (Source: Brachytherapy)
Source: Brachytherapy - March 4, 2013 Category: Cancer & Oncology Authors: Juanita M. Crook, Christine Haie-Meder, D. Jeffrey Demanes, Jean-Jacques Mazeron, Alvaro A. Martinez, Mark J. Rivard Source Type: research

Prognostic factors predicting ischemic wound healing following hyperbaric oxygenation therapy
Abstract Identifying patients who benefit from hyperoxygenation therapy is important, because treatment is time‐consuming and involves high costs and complications (minor). Our objective was to develop a model for predicting therapy outcome based on population of patients with and without diabetes. A retrospective cohort study was carried out in a major hospital in Israel. All 385 patients treated between 1/1/1998 and 1/1/2007 for ischemic nonhealing lower extremities wounds were included. Data on medical history, demographic, transcutaneous oximetry, wounds, treatment, and outcome characteristics were collected. Eight f...
Source: Wound Repair and Regeneration - March 1, 2013 Category: Surgery Authors: Yulie Feldman‐Idov, Yehuda Melamed, Shai Linn, Liora Ore Tags: Original Research‐Clinical Science Source Type: research

Microfluidic wound bandage: Localized oxygen modulation of collagen maturation
Abstract Restoring tissue oxygenation has the potential to improve poorly healing wounds with impaired microvasculature. Compared with more established wound therapy using hyperbaric oxygen chambers, topical oxygen therapy has lower cost and better patient comfort, although topical devices have provided inconsistent results. To provide controlled topical oxygen while minimizing moisture loss, a major issue for topical oxygen, we have devised a novel wound bandage based on microfluidic diffusion delivery of oxygen. In addition to modulating oxygen from 0 to 100% in 60 seconds rise time, the microfluidic oxygen bandage provi...
Source: Wound Repair and Regeneration - February 25, 2013 Category: Surgery Authors: Joe F. Lo, Martin Brennan, Zameer Merchant, Lin Chen, Shujuan Guo, David T. Eddington, Luisa A. DiPietro Tags: Original Research‐Basic Science Source Type: research

Effects of hyperbaric oxygen (HBO), as pre-conditioning in liver of rats submitted to periodic liver ischemia/reperfusion.
CONCLUSION: In this process of periodic ischemia and reperfusion, hyperbaric pre-conditioning did not improve significantly hepatic mitochondrial function. PMID: 23381827 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - February 22, 2013 Category: Surgery Authors: Caldeira DE, Souza ME, Gomes MC, Picinato MA, Fina CF, Feres O, Castro E Silva O Tags: Acta Cir Bras Source Type: research

Effect of hyperbaric oxygen therapy on liver function during intermittent ischemia.
CONCLUSION: The whole analysis of the mitochondiral function indicators permits us to conclude that the hyperbaric oxygen therapy acted as a protective agent of the mitochondrial function, minimizing the ischemia-reperfusion injury of the hepatic parenchyma. PMID: 23381826 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - February 22, 2013 Category: Surgery Authors: Baldim LB, Nejo R, Souza ME, Gomes MC, Picinato MA, Fina CF, Castro-E-Silva O Tags: Acta Cir Bras Source Type: research

Cohort study: Hyperbaric oxygen therapy not effective for diabetic foot ulcers and the prevention of amputation
Source: Diabetes Care Area: News A cohort study has found that hyperbaric oxygen (HBO) did not improve wound healing or prevent lower extremity amputation in patients with diabetic foot ulceration The researchers studied 6,259 individuals representing 767,060 person-days of wound care. In propensity score-adjusted models, individuals receiving HBO were less likely to have healing of their foot ulcer (hazard ratio, 0.68; 95% confidence interval, 0.63-0.73) and more likely to have an amputation (2.37 [1.84-3.04]) than those patients who did not receive HBO. The authors concluded that the usefulness of HB...
Source: NeLM - News - February 20, 2013 Category: Drugs & Pharmacology Source Type: news

Lack of Effectiveness of Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcer and the Prevention of Amputation: A cohort study.
CONCLUSIONSUse of HBO neither improved the likelihood that a wound would heal nor prevented amputation in a cohort of patients defined by Centers for Medicare and Medicaid Services eligibility criteria. The usefulness of HBO in the treatment of diabetic foot ulcers needs to be reevaluated. PMID: 23423696 [PubMed - as supplied by publisher] (Source: Diabetes Care)
Source: Diabetes Care - February 19, 2013 Category: Endocrinology Authors: Margolis DJ, Gupta J, Hoffstad O, Papdopoulos M, Glick HA, Thom SR, Mitra N Tags: Diabetes Care Source Type: research

Hyperoxia and Neutrophil {beta}2 Integrin Inhibition [Membrane Biology]
This investigation was to elucidate the basis for augmentation of nitric-oxide synthesis in neutrophils exposed to hyperbaric oxygen. Hyperoxia increases synthesis of reactive species leading to S-nitrosylation of β-actin, which causes temporary inhibition of β2 integrin adherence. Impaired β2 integrin function and actin S-nitrosylation do not occur in neutrophils from mice lacking type-2 nitric-oxide synthase (iNOS) or when incubated with 1400W, an iNOS inhibitor. Similarly, effects of hyperoxia were abrogated in cells depleted of focal adhesion kinase (FAK) by treatment with small inhibitory RNA and those exposed to a...
Source: Journal of Biological Chemistry - February 15, 2013 Category: Chemistry Authors: Thom, S. R., Bhopale, V. M., Milovanova, T. N., Yang, M., Bogush, M., Buerk, D. G. Tags: Cell Biology Source Type: research

DTB: Tinnitus
Source: DTB Area: Evidence > Disease Focused Reviews This review in the Drug and Therapeutics Bulletin (DTB) on tinnitus discusses assessment and referral, and symptomatic drug and non-drug treatments for subjective in adults. Non-drug treatment covered include: acupuncture, auditory perceptual training, cognitive behavioural therapy, hearing aids, hyperbaric oxygen therapy, hypnotherapy, information/education, low-power laser therapy, relaxation therapy, repetitive transcranial magnetic stimulation, sound enrichment or masking therapy, tinnitus retraining therapy, ultrasound. Drug treatments dis...
Source: NeLM - Disease Focused Reviews - February 14, 2013 Category: Internal Medicine Source Type: news

High altitude pulmonary edema-clinical features, pathophysiology, prevention and treatment
Swapnil J ParalikarIndian Journal of Occupational and Environmental Medicine 2012 16(2):59-62High altitude pulmonary edema (HAPE) is a noncardiogenic pulmonary edema which typically occurs in lowlanders who ascend rapidly to altitudes greater than 2500-3000 m. Early symptoms of HAPE include a nonproductive cough, dyspnoea on exertion and reduced exercise performance. Later, dyspnoea occurs at rest. Clinical features are cyanosis, tachycardia, tachypnoea and elevated body temperature generally not exceeding 38.5°C. Rales are discrete initially and located over the middle lung fields. HAPE mainly occurs due to ex...
Source: Indian Journal of Occupational and Environmental Medicine - February 13, 2013 Category: Occupational Health Authors: Swapnil J Paralikar Source Type: research

Severe blood loss anemia in a Jehovah's Witness treated with adjunctive hyperbaric oxygen therapy
We describe the case of a 39-year-old African-American woman who developed sudden onset, near-term placental abruption with severe blood loss anemia whose religious beliefs precluded her from receiving any blood products. The patient had lost most of her blood volume, with a reported hemoglobin level of 1.9 g/dL, developed multisystem failure, and disseminated intravascular coagulation with bilateral deep venous thrombosis. Adjunctive hyperbaric oxygenation (HBO) therapy was considered, and the patient was referred for treatment. The patient required ventilatory support as well as vasopressors and hemodialysis. HBO therapy...
Source: The American Journal of Emergency Medicine - February 4, 2013 Category: Emergency Medicine Authors: Charles Graffeo, William Dishong Tags: Case Reports Source Type: research

Hyperbaric oxygen therapy and ischemia and reperfusion: a valuable association to attenuate ischemic lesion and hepatic reperfusion.
CONCLUSION: The association between hyperbaric oxygen therapy and hepatic ischemia and reperfusion process was positive. PMID: 23370926 [PubMed - as supplied by publisher] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - February 1, 2013 Category: Surgery Authors: Losada DM, Souza ME, Jordani MC, Picinato MA, Fina CF, Feres O, Michelone PR, Silva OD Tags: Acta Cir Bras Source Type: research

Hyperbaric oxygen treatment new player in stroke rehabilitation
Treatment with hyperbaric oxygen therapy can lead to significant neurologic improvements for stroke patients, show study results. (Source: MedWire News - Stroke)
Source: MedWire News - Stroke - January 30, 2013 Category: Neurology Source Type: news

Hyperbaric Oxygen Therapy Has Significantly Resuscitated Activity In Damaged Brains
Stroke, traumatic injury, and metabolic disorder are major causes of brain damage and permanent disabilities, including motor dysfunction, psychological disorders, memory loss, and more. Current therapy and rehab programs aim to help patients heal, but they often have limited success. Now Dr. Shai Efrati of Tel Aviv University's Sackler Faculty of Medicine has found a way to restore a significant amount of neurological function in brain tissue thought to be chronically damaged - even years after initial injury. Theorizing that high levels of oxygen could reinvigorate dormant neurons, Dr... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 25, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Oxygen chamber can boost brain repair years after stroke or trauma
Through the use of hyperbaric, oxygen-rich chambers, medical researchers have found a way to restore a significant amount of neurological function in brain tissue thought to be chronically damaged by stroke, traumatic injury, and metabolic disorder -- even years after the original injury. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 23, 2013 Category: Science Source Type: news

Oxygen chamber can boost brain repair
(American Friends of Tel Aviv University) Through the use of hyperbaric, oxygen-rich chambers, Tel Aviv University's Dr. Shai Efrati has found a way to restore a significant amount of neurological function in brain tissue thought to be chronically damanged by stroke, traumatic injury, and metabolic disorder -- even years after the original injury. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 23, 2013 Category: Global & Universal Source Type: news

Hypothermia and xenon: Novel noble guardians in hypoxic–ischemic encephalopathy?
Abstract The financial and emotional cost of caring for children affected by hypoxic–ischemic encephalopathy (HIE) is enormous, and developing therapeutic strategies to prevent or ameliorate the severity of HI‐related brain injury remains a major priority. In the past, supportive management was the mainstay of treatment, but considerable progress has been made in identifying and developing neuroprotective strategies for neonates with HIE. The neuroprotective effects of several therapeutic modalities, including anticonvulsants, hyperbaric oxygen, and erythropoietin, have been investigated. This Mini‐Review discusses t...
Source: Journal of Neuroscience Research - January 18, 2013 Category: Neuroscience Authors: N. Lobo, B. Yang, M. Rizvi, Daqing Ma Tags: Mini‐Review Source Type: research

Vasoconstrictor responsiveness during hyperbaric hyperoxia in contracting human muscle
Large increases in systemic oxygen content cause substantial reductions in exercising forearm blood flow (FBF) due to increased vascular resistance. We hypothesized that 1) functional sympatholysis (blunting of sympathetic α-adrenergic vasoconstriction) would be attenuated during hyperoxic exercise and 2) α-adrenergic blockade would limit vasoconstriction during hyperoxia and increase FBF to levels observed under normoxic conditions. Nine male subjects (age 28 ± 1 yr) performed forearm exercise (20% of maximum) under normoxic and hyperoxic conditions. Studies were performed in a hyperbaric chamber at 1 a...
Source: Journal of Applied Physiology - January 15, 2013 Category: Physiology Authors: Casey, D. P., Joyner, M. J., Claus, P. L., Curry, T. B. Tags: ARTICLES Source Type: research

Effect of hyperbaric oxygen on neurological recovery of neonatal rats following hypoxic-ischemic brain damage and its underlying mechanism.
CONCLUSION: HBO may promote the neurological recovery in neonatal rats with HIBD, which may be attributed to the increased protein and mRNA expression of BMP-4 and nestin in the hippocampus and the inhibition of neural apoptosis. PMID: 23236544 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 14, 2013 Category: Pathology Authors: Yin X, Meng F, Wang Y, Wei W, Li A, Chai Y, Feng Z Tags: Int J Clin Exp Pathol Source Type: research

Effects of hyperbaric oxygen and N-acetylcysteine in survival of random pattern skin flaps in rats
Conclusion: HBO is associated with reduced area of necrosis of skin flap. The G-NAC group was associated with poor results when examined in isolation. The association between HBO and NAC did not produce favourable results with respect to the use of HBO alone. These findings suggest that the diffusion of oxygen through the interstitial space was the determining factor of more favourable results of HBO. (Source: Indian Journal of Plastic Surgery)
Source: Indian Journal of Plastic Surgery - January 12, 2013 Category: Cosmetic Surgery Authors: Fernando P da RochaDjalma J FagundesJefferson A PiresFernanda Salim T da Rocha Source Type: research

SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain
& Lize Xiong (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - January 9, 2013 Category: Neurology Authors: Wenjun YanZongping FangQianzi YangHailong DongYan LuChong LeiLize Xiong Tags: cerebral ischemia/reperfusion hyperbaric oxygen preconditioning neuroprotection oxygen–glucose deprivation SirT1 Source Type: research

Hyperbaric oxygen and hyperbaric air treatment result in comparable neuronal death reduction and improved behavioral outcome after transient forebrain ischemia in the gerbil.
Abstract Anoxic brain injury resulting from cardiac arrest is responsible for approximately two-thirds of deaths. Recent evidence suggests that increased oxygen delivered to the brain after cardiac arrest may be an important factor in preventing neuronal damage, resulting in an interest in hyperbaric oxygen (HBO) therapy. Interestingly, increased oxygen supply may be also reached by application of normobaric oxygen (NBO) or hyperbaric air (HBA). However, previous research also showed that the beneficial effect of hyperbaric treatment may not directly result from increased oxygen supply, leading to the conclusion th...
Source: Experimental Brain Research - January 1, 2013 Category: Neuroscience Authors: Malek M, Duszczyk M, Zyszkowski M, Ziembowicz A, Salinska E Tags: Exp Brain Res Source Type: research

Adjunctive hyperbaric oxygen therapy in the treatment of thermal burns.
Abstract A significant and consistently positive body of evidence from animal and human studies of thermal injury support the use of hyperbaric oxygen as a means of preventing dermal ischemia, reducing edema, modulating the zone of stasis, preventing partial- to full-thickness conversion, preserving cellular metabolism and promoting of healing. The vast majority of clinical reports have shown reduction in mortality, length of hospital stay, number of surgeries and cost of care. Hyperbaric oxygen has been demonstrated to be safe in the hands of those thoroughly trained in rendering therapy in the critical care setti...
Source: Undersea and Hyperbaric Medicine - January 1, 2013 Category: Sports Medicine Authors: Cianci P, Slade JB, Sato RM, Faulkner J Tags: Undersea Hyperb Med Source Type: research

Treatment of carbon monoxide poisoning with hyperbaric oxygen and therapeutic hypothermia.
We present a preliminary case report series of severe, acute carbon monoxide poisoning in which both hyperbaric oxygen (HBO2) and therapeutic hypothermia (TH) were used to ameliorate neurological sequelae. Carbon monoxide poisoning is a standard indication for HBO2. While typically used postcardiac arrest, TH has been used for other types of hypoxic-ischemic brain injury. Four patients were found comatose from carbon monoxide exposure. They were intubated and treated with high-flow oxygen before transfer to our hospital for HBO2. All received three HBO2 treatments and 24 hours of TH with a goal temperature of 33 degrees C ...
Source: Undersea and Hyperbaric Medicine - January 1, 2013 Category: Sports Medicine Authors: Feldman J, Renda N, Markovitz GH, Chin W, Sprau SE Tags: Undersea Hyperb Med Source Type: research

Development of underwater and hyperbaric medicine as a medical specialty in Turkey.
Abstract Underwater and hyperbaric medicine focuses on diving physiology, prevention and treatment of health problems related to the exposure to high ambient pressure and therapeutic use of hyperbaric oxygen for several medical conditions. Adequate educational standards should be developed for physicians working in the field of underwater and hyperbaric medicine. In Turkey, underwater and hyperbaric medicine is one of the medical specialties. The history of underwater and hyperbaric medicine as a medical specialty is dated back to the 1960s. In this paper, we review standards and the development of underwater and h...
Source: Undersea and Hyperbaric Medicine - January 1, 2013 Category: Sports Medicine Authors: Aktaş S, Toklu AS, Yildiz S, Uzun G Tags: Undersea Hyperb Med Source Type: research

Diffusion tensor MRI of spinal decompression sickness.
In this study, we measured FA and MD in white and gray matter spinal cord regions in samples taken from sheep following hyperbaric exposure to 60-132 fsw and 0-180 minutes of oxygen pre-breathing treatment before rapid decompression. The main finding of the study was that decompression from >60 fsw resulted in reduced FA that was associated with cell death and disrupted tissue microstructure in spinal cord white matter tracts. Additionally, animals exposed to prolonged oxygen pre-breathing prior to decompression demonstrated reduced MD in spinal cord gray matter regions regardless of dive depth. To our knowledge, this i...
Source: Undersea and Hyperbaric Medicine - January 1, 2013 Category: Sports Medicine Authors: Hutchinson EB, Sobakin AS, Meyerand ME, Eldridge M, Ferrazzano P Tags: Undersea Hyperb Med Source Type: research

Effects of ultra-early stage hyperbaric oxygenation on the hind limb bone mineral density in rats after complete spinal cord transection.
CONCLUSION: Ultra-early stage hyperbaric oxygenation alleviates the hind limb bone loss in femur bone in rats following complete spinal cord transection. PMID: 23397864 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)
Source: Undersea and Hyperbaric Medicine - January 1, 2013 Category: Sports Medicine Authors: Liu M, Wu X, Tong M Tags: Undersea Hyperb Med Source Type: research

Exhaled nitric oxide and lung function after moderate normobaric hyperoxic exposure.
DISCUSSION: Unchanged indices of distribution of ventilation and maximal expiratory flow rates indicate no small airways' dysfunction, and unchanged DLCO suggests preserved gas transfer in the lung despite a significant reduction in FE(NO). FE(NO) might be an index of oxygen exposure, but further studies over a wide range of oxygen exposures are necessary to establish the role of FE(NO) as a marker of pulmonary oxygen toxicity. PMID: 23397863 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)
Source: Undersea and Hyperbaric Medicine - January 1, 2013 Category: Sports Medicine Authors: Caspersen C, Stensrud T, Storebø M, Thorsen E Tags: Undersea Hyperb Med Source Type: research

Hyperbaric oxygen and burns: an editorial perspective.
PMID: 23397862 [PubMed - in process] (Source: Undersea and Hyperbaric Medicine)
Source: Undersea and Hyperbaric Medicine - January 1, 2013 Category: Sports Medicine Authors: Hunt TK Tags: Undersea Hyperb Med Source Type: research

The protective effect of hyperbaric oxygen and Ginkgo biloba extract on Aβ25-35-induced oxidative stress and neuronal apoptosis in rats.
Abstract Alzheimer's disease (AD) is characterized by accumulation and deposition of Aβ peptides in human brains. The present study aimed to determine the protective effect of HBO and EGB761 on Aβ25-35 peptides induced cognitive impairment and neuronal toxicity in rats. Characteristics of AD were induced in rats by the administration of Aβ25-35 in hippocampus. Rats were treated with HBO (2ATA 60min/day), EGB761 (20mg/kg/day), and the combination of HBO+EGB761 (20mg/kg/day+2ATA). The Morris water maze was used to detect the protective effects of HBO and EGB761 against cognitive impairment. The activities of SOD a...
Source: Behavioural Brain Research - December 22, 2012 Category: Neurology Authors: Tian X, Zhang L, Wang J, Dai J, Shen S, Yang L, Huang P Tags: Behav Brain Res Source Type: research

New draft national commissioning policies that impact on medicines issued for consultation
Source: NHS Commissioning Board Area: News The NHS Commissioning Board has issued a number of draft national policies which impact on medicines, including the following: . Rituximab for systemic lupus erythematosus (SLE) . Rituximab for ANCA vasculitis . Targeted therapies for Class II pulmonary hypertension . Siklos® in sickle cell anaemia . Treatment of acute attacks in hereditary angioedema . Disease-modifying therapies for multiple sclerosis . Amifampridine (Firdapse®) for Lambert-Eaton Myasthenic Syndrome (LEMS) . Co-careldopa intestinal ge...
Source: NeLM - Cardiovascular Medicine - December 17, 2012 Category: Cardiology Source Type: news

Hyperbaric oxygenation alters temporal expression pattern of superoxide dismutase 2 after cortical stab injury in rats.
Conclusion. HBOT alters SOD2 protein and mRNA levels after brain injury in a time-dependent manner. PMID: 23275324 [PubMed - in process] (Source: Croatian Medical Journal)
Source: Croatian Medical Journal - December 15, 2012 Category: Journals (General) Authors: Parabucki AB, Bozic ID, Bjelobaba IM, Lavrnja IC, Brkic PD, Jovanovic TS, Savic DZ, Stojiljkovic MB, Pekovic SM Tags: Croat Med J Source Type: research

Status epilepticus and cardiopulmonary arrest in a patient with carbon monoxide poisoning with full recovery after using a neuroprotective strategy: a case report
Conclusions: Brain protective modalities are very important for the treatment of complicated cases of carbon monoxide poisoning when they present with neurological toxicities or cardiac arrest. They can be adjunctive to normobaric oxygen therapy when the use of hyperbaric oxygen is not feasible. (Source: BioMed Central)
Source: BioMed Central - December 14, 2012 Category: Journals (General) Authors: Salman AbdulazizOusama DabbaghYaseen ArabiSuleiman KojanImad Hassan Source Type: research

Government tyranny vs parental rights in the UK
UK case the latest in a worrying trend toward medical authoritarianism (Source: Alliance for Natural Health)
Source: Alliance for Natural Health - December 12, 2012 Category: Complementary Medicine Authors: Sophie Tags: Brain tumour cancer chenotherapy europe hyperbaric oxygen therapy international medulloblastoma Mrs Roberts Neon Roberts oncology parental rights radiation radiotherapy Source Type: news

Symmetrical peripheral gangrene and the use of systemic hyperbaric oxygen therapy
Journal of Wound Care, Vol. 21, Iss. 12, 11 Dec 2012, pp 615 - 619 (Source: Contents for Journal of Wound Care, Volume 18 Issue 4 (26 March 2009))
Source: Contents for Journal of Wound Care, Volume 18 Issue 4 (26 March 2009) - December 10, 2012 Category: Nursing Authors: S. Stewart Source Type: research

Cosmetic effect of hyperbaric oxygen.
PMID: 23212538 [PubMed - as supplied by publisher] (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - December 2, 2012 Category: Cytology Authors: Ye ZH, Liu WW, Sun XJ Tags: Cell Stress Chaperones Source Type: research

Clinical effectiveness of early treatment with hyperbaric oxygen therapy for severe late‐onset hemorrhagic cystitis after hematopoietic stem cell transplantation in pediatric patients
We report our single center experience with HOT in late‐onset HC after HSCT. Treatment with HOT consisted of daily sessions of breathing 100% O2 for a total of 75 min in the hyperbaric chamber with a minimum of eight sessions. HOT had been associated with a concomitant treatment with oral oxybutynin, hyperhydration and/or irrigation of the bladder through the catheter. Cidofovir had been administered based on the demonstration of viral infection. Between 2004 and 2011, 10 patients developed severe HC after a median of 26 days after HSCT. HOT was started after a median of six days since the clinical diagnosis of HC. Aft...
Source: Pediatric Transplantation - December 1, 2012 Category: Transplant Surgery Authors: Daniele Zama, Riccardo Masetti, Francesca Vendemini, Ferruccio Di Donato, Alessandra Morelli, Arcangelo Prete, Andrea Pession Tags: Original Article Source Type: research

Chronic leg ulcers in adult patients with rheumatological diseases – a 7‐year retrospective review
Chronic leg ulcers in patients with rheumatological diseases can cause significant morbidity. We performed a retrospective case review to describe the epidemiology, clinical features and outcome of chronic leg ulcers in this group of patients. Twenty‐nine patients with underlying rheumatological conditions, namely, rheumatoid arthritis (15 patients), systemic lupus erythematosus (8 patients), overlap syndromes (3 patients), systemic sclerosis (1 patient) and ankylosing spondylitis (1 patient) were included. The ulcers were mostly located around the ankle (55·2%) and calves (37·9%). The predominant aetiology of the ulce...
Source: International Wound Journal - December 1, 2012 Category: Surgery Authors: Hui Y Chia, Mark BY Tang Source Type: research