Immature Teratoma
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32 records returned
Imaging of ovarian teratomas: Appearances and complications
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Ovarian teratomas are the most common germ cell neoplasm. Subtypes of teratoma include mature cystic, immature and the monodermal teratomas. The benign cystic teratoma shows typical imaging manifestations and can be complicated by torsion, rupture and uncommonly malignant degeneration. Uncommon subtypes of teratomas include the immature, which is usually malignant at diagnosis. The growing teratoma syndrome is an uncommon complication reported in patients treated for immature teratomas. The monodermal teratomas which include the struma ovarii may also have specific imaging characteristics that should be recognised on imagi...
Source: Australasian Radiology - September 27, 2009 Category: Radiology Authors: S Choudhary, N Fasih, M Mc Innes, C Marginean Tags: RADIOLOGY Source Type: journals
Intrathoracic glial implants in a child with gliomatosis peritonei
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This report provides evidence to bolster the metaplastic theory. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - August 31, 2009 Category: Surgery Authors: Aaron M. Lipskar, David H. Rothstein, Samuel Z. Soffer, Morris Edelman, Richard D. Glick Tags: Case Reports Source Type: journals
Management of primary intracranial germ cell tumors
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Abstract Primary intracranial germ cell tumors are rare and usually localized in the pineal and the suprasellar regions. They are divided
into the following histologic types: germinoma, teratoma (mature, immature, malignant), choriocarcinoma, embryonal carcinoma,
endodermal sinus tumor (yolk sac tumor), and mixed tumors. Clinically, they are manifested with ocular signs or signs of obstructive
hydrocephalus. Localized germinomas are treated with radiation therapy and exhibit a relatively good prognosis. Chemotherapy
is reserved for disseminated germinomas. Mature teratomas are treated with surgery. The rest ...
Source: Journal of Neuro-Oncology - July 9, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals
[Epidemiology and pathological profile of childhood ovary tumours in Togo: about 32 cases.]
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ConclusionThe childhood ovary tumours although rare, exist in Togo dominated by Burkitt lymphoma.
PMID: 19457758 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 19, 2009 Category: Cancer & Oncology Authors: Amégbor K, Darre T, Alfa AK, Napo-Koura G Tags: Bull Cancer Source Type: journals
Ovarian Immature Teratoma
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Immature teratomas of the ovary are rare germ cell malignancies. They are very different from the more common mature cystic teratoma, which is not malignant. (Source: About.com Ovarian Cancer)
Source: About.com Ovarian Cancer - March 7, 2009 Category: Cancer & Oncology Tags: health Source Type: consumer
Alpha-fetoprotein levels correlate with the pathologic grade and surgical outcomes of pediatric retroperitoneal teratomas
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Conclusion We conclude that AFP levels correlate with tumor immaturity and predict operative morbidity even in patients less than 2 months
of age. Despite the increased morbidity associated with surgical excision of high-grade RTs, complete resection results in
long-term disease-free survival in the majority of infants with this rare pediatric neoplasm.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00383-009-2321-2Authors
Catherine Jane Hunter, University of Southern California, Keck School of Medicine, Childrens Hospital Los Angeles Department of Surgery 4650 Sunset Blvd., Mail St...
Source: Pediatric Surgery International - February 7, 2009 Category: Surgery Tags: Pediatric Surgery International Source Type: journals
[AFIP Archives] From the Archives of the AFIP: Fat-containing Lesions of the Retroperitoneum: Radiologic-Pathologic Correlation
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Retroperitoneal lesions represent a broad, diverse collection of entities; when they contain fat, the differential diagnosis, which ranges from benign to fully malignant lesions, substantially narrows. Lipomas rarely occur in the retroperitoneum; thus, fat-containing lesions in this location should never be dismissed as lipoma. Pelvic lipomatosis is the overgrowth of histologically normal fat in the extraabdominal compartments of the pelvis along the perirectal and perivesicular spaces. Infants and young children develop lipoblastomas rather than liposarcomas, which occur in older patients. Liposarcomas typically occur in ...
Source: Radiographics recent issues - January 23, 2009 Category: Radiology Authors: Craig, W. D., Fanburg-Smith, J. C., Henry, L. R., Guerrero, R., Barton, J. H Tags: Oncologic Imaging, Genitourinary Radiology AFIP Archives Source Type: journals
[AFIP Archives] Fat-containing Lesions of the Retroperitoneum: Radiologic-Pathologic Correlation
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Retroperitoneal lesions represent a broad, diverse collection of entities; when they contain fat, the differential diagnosis, which ranges from benign to fully malignant lesions, substantially narrows. Lipomas rarely occur in the retroperitoneum; thus, fat-containing lesions in this location should never be dismissed as lipoma. Pelvic lipomatosis is the overgrowth of histologically normal fat in the extraabdominal compartments of the pelvis along the perirectal and perivesicular spaces. Infants and young children develop lipoblastomas rather than liposarcomas, which occur in older patients. Liposarcomas typically occur in ...
Source: Radiographics recent issues - January 23, 2009 Category: Radiology Authors: Craig, W. D., Fanburg-Smith, J. C., Henry, L. R., Guerrero, R., Barton, J. H Tags: Oncologic Imaging, Genitourinary Radiology AFIP Archives Source Type: journals
Fat-containing Lesions of the Retroperitoneum: Radiologic-Pathologic Correlation [AFIP Archives]
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Retroperitoneal lesions represent a broad, diverse collection of entities; when they contain fat, the differential diagnosis, which ranges from benign to fully malignant lesions, substantially narrows. Lipomas rarely occur in the retroperitoneum; thus, fat-containing lesions in this location should never be dismissed as lipoma. Pelvic lipomatosis is the overgrowth of histologically normal fat in the extraabdominal compartments of the pelvis along the perirectal and perivesicular spaces. Infants and young children develop lipoblastomas rather than liposarcomas, which occur in older patients. Liposarcomas typically occur in ...
Source: Radiographics recent issues - January 23, 2009 Category: Radiology Authors: Craig, W. D., Fanburg-Smith, J. C., Henry, L. R., Guerrero, R., Barton, J. H Tags: Oncologic Imaging, Genitourinary Radiology AFIP Archives Source Type: journals
Expression of Glial Cell Line-Derived Neurotropic Factor Receptor alpha-1 in Immature Teratomas.
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In this study, we evaluated the expression of glial cell line-derived neurotropic factor receptor alpha-1 (GFRalpha-1) for this purpose. We retrieved 38 cases of germ cell tumors: 26 cases contained immature teratoma, of which 24 had immature neuroepithelium and showed strong membrane staining for GFRalpha-1. No significant staining was seen in other components including embryonal carcinoma, seminoma, yolk sac tumor, choriocarcinoma, immature mesenchyme, and intratubular germ cell neoplasia. Immunohistochemical staining for GFRalpha-1 in immature neuroepithelium may facilitate its identification.
PMID: 19019765 [PubMed...
Source: American Journal of Clinical Pathology - November 21, 2008 Category: Pathology Authors: Bing Z, Pasha TL, Lal P, Tomaszewski JE Tags: Am J Clin Pathol Source Type: journals
Mature and immature ovarian teratomas: CT, US and MR imaging characteristics.
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Ovarian teratomas (OTs) are the most common germ cell neoplasm. They include mature cystic teratomas, monodermal teratomas (neural tumors, struma ovarii, carcinoid tumors) and immature teratomas. Teratomas are the most common benign ovarian neoplasms in women less than 45 years old. OTs are usually characterized by ultrasound (US) and magnetic resonance (MR) whereas they are usually an incidental finding on CT. The purpose of this paper is to review the most common types of teratomas and to describe CT, US and MR imaging features of the various types of mature and immature OTs.
PMID: 18804932 [PubMed - as supplied ...
Source: European Journal of Radiology - September 19, 2008 Category: Radiology Authors: Saba L, Guerriero S, Sulcis R, Virgilio B, Melis G, Mallarini G Tags: Eur J Radiol Source Type: journals
Expression of glypican 3 in ovarian and extragonadal germ cell tumors.
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Germ cell tumors (GCTs), rare malignancies that occur in a wide range of locations and display variable histologic patterns, may pose diagnostic challenges. Glypican 3 (GPC3), a membrane-bound heparan sulfate proteoglycan, has been shown to be a novel diagnostic marker in testicular GCT. However, GPC3 expression in ovarian and extragonadal GCT has not been reported. We evaluated GPC3 immunoreactivity in GCTs from 63 patients (57 children and 6 adults), including 14 ovarian and 20 extragonadal primary GCTs and 8 metastases along with 21 primary testicular GCTs for comparison. All 33 yolk sac tumors (YSTs) and both chori...
Source: American Journal of Clinical Pathology - July 17, 2008 Category: Pathology Authors: Zynger DL, Everton MJ, Dimov ND, Chou PM, Yang XJ Tags: Am J Clin Pathol Source Type: journals
The distinction of bronchogenic cyst from metastatic testicular teratoma: a light microscopic and immunohistochemical study.
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Bronchogenic cyst (BC), a rare developmental abnormality of the primitive foregut and usually found above the diaphragm, can occur in the retroperitoneum and other unusual locations where distinction from metastatic teratoma is essential. We studied 22 BCs and 34 teratomas metastatic to the retroperitoneum in men. Of 22 BCs, 17 (77%) showed well or moderate architectural differentiation toward normal tracheobronchial structures, whereas none of the teratomas did. In addition, 20 (91%) of the BCs had respiratory-type epithelium and none had enteric-type epithelium. Immature elements, atypia, and tumor necrosis were abse...
Source: American Journal of Clinical Pathology - July 17, 2008 Category: Pathology Authors: Roma A, Varsegi M, Magi-Galluzzi C, Ulbright T, Zhou M Tags: Am J Clin Pathol Source Type: journals
[Pediatric Oncology] Mature and Immature Extracranial Teratomas in Children: The UK Children's Cancer Study Group Experience
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Conclusion
Treatment remains primarily surgical, with JEB chemotherapy for YST relapse. No definite response followed JEB for pure MT and IT. Adjuvant chemotherapy after surgery for sacrococcygeal patients is not advocated. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - July 17, 2008 Category: Cancer & Oncology Authors: Mann, Gray, Thornton, Raafat, Robinson, Collins, Gornall, Huddart, Hale, Oakhill Tags: Germ Cell Tumors Pediatric Oncology Source Type: journals
[RSNA Education Exhibits] Imaging Findings of Complications and Unusual Manifestations of Ovarian Teratomas
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Ovarian teratomas can be associated with various complications and demonstrate a wide spectrum of clinical and imaging features. The complications include torsion (16% of ovarian teratomas), rupture (1%–4%), malignant transformation (1%–2%), infection (1%), and autoimmune hemolytic anemia (<1%). These complications require different therapeutic strategies; therefore, timely and accurate diagnosis of these complications is important for optimal patient treatment. In cases of complicated ovarian teratomas, the clinical manifestations provide only limited information and often overlap with those of other diseas...
Source: Radiographics recent issues - July 17, 2008 Category: Radiology Authors: Park, S. B., Kim, J. K., Kim, K.-R., Cho, K.-S. Tags: Obstetric/Gynecologic Radiology, Oncologic Imaging, Genitourinary Radiology RSNA Education Exhibits Source Type: journals
First description of malignant retrobulbar and intracranial teratoma in a lesser kestrel (Falco naumanni).
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Teratomas are defined as germ cell origin neoplasms that can be rarely found in either humans or animals. Their most common localization is the gonads, although extragonadal localization has also been observed. In avian medicine, there is scarce literature about the occurrence of teratomas and their clinical implications, and this is mainly in wildlife birds . For this reason, we report the first description of a teratoma with both retrobulbar and intracranial locations in a 10-day-old chick of a lesser kestrel (Falco naumanni) born in captivity. The raptor was treated in a centre of wildlife rehabilitation because of ...
Source: Avian Pathology - July 16, 2008 Category: Pathology Authors: López RM, Múrcia DB Tags: Avian Pathol Source Type: journals
Murine embryonic stem cell-derived hepatic progenitor cells engraft in recipient livers with limited capacity of liver tissue formation.
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In conclusion, the limited repopulation capacity of ES-HPC is not caused by a failure of primary engraftment, but may be due to an immature hepatic phenotype of the transplanted ES-HPC.
PMID: 18522234 [PubMed - in process] (Source: Cell Transplantation)
Source: Cell Transplantation - July 16, 2008 Category: Cytology Authors: Sharma AD, Cantz T, Vogel A, Schambach A, Haridass D, Iken M, Bleidissel M, Manns MP, Schöler HR, Ott M Tags: Cell Transplant Source Type: journals
Bifocal mixed germ-cell tumor with growing teratoma syndrome and metachronous mature metastases: case report
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Abstract The authors report the case of a 16-year-old male who presented with a bifocal diencephalic tumor arising both in the neurohypophysis
and the pineal region with hydrocephalus. The histological diagnosis obtained during endoscopic ventriculocisternostomy was
germinoma. MRI revealed an increase of the neoplasm during chemotherapy with recurrent obstructive hydrocephalus. A new ventriculostomy
was performed followed by total surgical resection. The final histopathological analysis demonstrated an immature teratoma.
Subsequently, this patient developed metachronous cystic metastases in the cerebello-pon...
Source: Journal of Neuro-Oncology - June 24, 2008 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals
The influence of conservative surgical practices for malignant ovarian germ cell tumors
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To evaluate demographics, survival, and surgical trends for patients with malignant ovarian germ cell tumors.SEER data abstracted from 1988 to 2001 and analyzed using Kaplan-Meier and Cox regression models.Of 760 patients, the median age was 23 years. Seventy-six percent of patients presented with stage I-II disease, and 24% with stage III-IV. Fifty-five percent were immature teratomas, 32% dysgerminomas, and 13% yolk sac tumors. Fertility-preserving surgery was performed in 41.2% (n = 313) of patients. In those (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - June 18, 2008 Category: Cancer & Oncology Authors: John K. Chan, Krishnansu S. Tewari, Sarah Waller, Michael K. Cheung, Jacob Y. Shin, Kathryn Osann, Daniel S. Kapp Source Type: journals
Accumulation of gallium-67 within mature and immature teratoma in pediatric patients: investigation for the uptake mechanism
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Conclusions A high-uptake ratio of 67Ga in benign teratoma was indicated. A close correlation between gallium scan and CT helps to ascertain whether 67Ga uptake results from malignant and/or immature elements, or mature tissue components.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12149-007-0095-yAuthors
Etsuo Kunieda, Tokyo Metropolitan Kiyose Children’s Hospital Department of Radiology Kiyose, Tokyo JapanHiroko Hara, Kawaguchi Municipal Hospital Department of Radiology Kawaguchi, Saitama JapanYukihiko Morikawa, Tokyo Metropolitan Kiyose Children’s Hospital Department of Path...
Source: Annals of Nuclear Medicine - May 23, 2008 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: journals
Influence of Tumor Site and Histology on Long-Term Survival in 193 Children with Extracranial Germ Cell Tumors
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Eur J Pediatr Surg 2008; 18: 1-6DOI: 10.1055/s-2007-989399Abstract Although germ cell tumors (GCT) supposedly share the same cell type of origin, their clinical course differs considerably depending on tumor site and histology. The aim of this work was to study long-term survival stratified for tumor site and tumor histology. The medical records of 193 consecutive infants and children with extracranial GCT were studied. The GCT arose in the following anatomical sites: sacrococcygeal (n = 70), ovary (n = 66), testis (n = 20), retroperitoneum (n = 12), neck (n = 8), mediastinum (n = 7), and miscellaneous (n = 10). Histologic...
Source: European Journal of Pediatric Surgery - February 27, 2008 Category: Surgery Tags: Original Article Source Type: journals
Nestin expression in central nervous system germ cell tumors
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In this study, we examined for the first time nestin expression in 19 CNS germ cell tumors (nine pure germinomas,
five germinomas with syncytiotrophoblastic giant cells, one yolk sac tumor, one choriocarcinoma, one embryonal carcinoma,
and two mature teratomas). Nestin was expressed in 14 cases but was not expressed in three pure germinomas and two mature
teratomas. Clinically, nestin-negative tumors did not exhibit dissemination, while all tumors that exhibited dissemination
also strongly expressed nestin protein. These findings suggest that the detection of nestin expression could be useful in
the management of CNS ...
Source: Urosurgical Review - December 19, 2007 Category: Urology & Nephrology Tags: Neurosurgical Review Source Type: journals
A patient with bilateral immature ovarian teratoma presenting with paraneoplastic encephalitis.
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CONCLUSION.: In case a young woman presents with encephalitis of unknown origin she should also be referred to the gynecologist to rule out ovarian pathology, especially since surgical removal of a teratoma may result in clinical improvement or even complete recovery.
PMID: 18029289 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - November 19, 2007 Category: Cancer & Oncology Authors: van Altena AM, Wijnberg GJ, Kolwijck E, de Hullu JA, Massuger LF Tags: Gynecol Oncol Source Type: journals
Uterine cervical teratoma with divergent neuroepithelial differentiation and development of an oligodendroglioma: report of a case and review of the literature.
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We describe a case of uterine cervical teratoma exhibiting ectodermal, endodermal, mesodermal, and various types of neuroepithelial differentiation and development of a small oligodendroglioma in a 38-year-old female. The presence of immature neuroepithelium defines this teratoma as immature, and the development of a low-grade malignant neoplasm from one of its components makes it malignant. The pertinent literature is reviewed.
PMID: 17630116 [PubMed - in process] (Source: Annals of Diagnostic Pathology)
Source: Annals of Diagnostic Pathology - July 17, 2007 Category: Pathology Authors: Panesar NK, Sidhu JS Tags: Ann Diagn Pathol Source Type: journals
Primary malignant teratoma with a primitive neuroectodermal tumor component in thyroid gland: a case report.
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We report a case of a 31-yr-old female with a huge neck mass. Pathologic examination revealed it to be malignant teratoma composed of primitive neuroepithelial tissue with primitive neural tubes and loose myxoid to fibrous immature mesenchymal stroma. The patient underwent extensive evaluation of the thyroid gland with computed tomography (CT) scan and positron emission tomography (PET) scan, which revealed no evidence of metastatic disease. She underwent total thyroidectomy with bilateral modified radical neck dissection, intensive chemotherapy and radiotherapy. At 22-months of follow-up, the patient has remained euthyroi...
Source: J Korean Med Sci - June 1, 2007 Category: Journals (General) Authors: Kim E, Bae TS, Kwon Y, Kim TH, Chung KW, Kim SW, Ro J, Lee ES Tags: J Korean Med Sci Source Type: journals
Expression of Sox2 in mature and immature teratomas of central nervous system
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& Kyu-Chang Wang (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - April 27, 2007 Category: Pathology Authors: Ji Hoon PhiSung-Hye ParkSun Ha PaekSeung-Ki KimYun Jin LeeChul-Kee ParkByung-Kyu ChoDo-Hun LeeKyu-Chang Wang Source Type: journals
Prognostic factors and role of salvage surgery in chemorefractory ovarian germ cell malignancies: A study in Chinese patients.
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CONCLUSIONS.: Chemorefractory cases with dysgerminoma or immature teratoma appear to have better outcome than the other subtypes. When offered standard BEP/PVB regimen as salvage chemotherapy, patients with chemorefractory disease after non-BEP/PVB primary chemotherapy have better prognosis. Optimal cytoreduction during salvage surgery does benefit chemorefractory patients.
PMID: 17459461 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 23, 2007 Category: Cancer & Oncology Authors: Li J, Yang W, Wu X Tags: Gynecol Oncol Source Type: journals
Mature and immature teratomas: results of the first paediatric Italian study
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Abstract??Teratoma is the most common germ cell tumour in childhood; mature (MT) and immature teratomas (IT) are benign tumours, but if they recur, they can be in some cases malignant. The aim of this paper is to evaluate Italian patients with MT and IT enrolled from 1991 to 2001, in a prospective multicentric study. One hundred and eighty-three patients, observed in 15 Italian Centers of Paediatric Oncology and three Paediatric Surgical Units were enrolled. Clinical data, treatment and results were all analysed. Initial evaluation and subsequent follow up included clinical examination, tumour markers and imaging procedure...
Source: Pediatric Surgery International - March 2, 2007 Category: Surgery Tags: Pediatric Surgery International Source Type: journals
Cytopathologic findings in an immature cystic teratoma: Report of an unusual case
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We describe the cytopathology of an unusual case of a large congenital teratoma in a 6-day-old girl. The patient initially showed signs of abdominal distention and a follow-up ultrasound and computerized-tomography (CT) revealed a cystic mass in the pelvis. An ultrasound-guided fine-needle aspiration (FNA) showed small round blue cells suspicious for a primitive neuronal tumor. Resection of the mass displayed a cystic teratoma with distinct nests of small round blue cells representing immature neuroepithelial and glial tissue. Also noted were admixed mature elements of a cystic teratoma. Cytologic finding of a small round ...
Source: Diagnostic Cytopathology - January 17, 2007 Category: Pathology Authors: Michael T. Balco, Frances H. Burroughs, Syed Z. Ali Source Type: journals
[CASE REPORTS] Treatment of Mediastinal Immature Teratoma in a Child With Precocious Puberty and Klinefelter's Syndrome
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Teratoma is the most common germ cell tumor, which can be divided into the mature and the immature histologically. Concurrent Klinefelter's syndrome may be overlooked in a patient with a germ cell tumor. This is because the tumor that secrets alpha-fetoprotein and beta human chorionic gonadotropin can mimic puberty in a patient with Klinefelter's syndrome, masking the usual clinical signs. In reviewing the literature on the subject, the role of neoadjuvant and adjuvant chemotherapy remains ill-defined for the immature teratoma. Age-dependent prognosis seems to demonstrate that children with immature teratomas have a better...
Source: The Annals of Thoracic Surgery - November 1, 2006 Category: Cardiovascular & Thoracic Surgery Authors: Chen, C.-K., Chang, Y.-L., Jou, S.-T., Tseng, Y.-T., Lee, Y.-C. Source Type: journals
Factors associated with recurrence and metastasis in sacrococcygeal teratoma
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Sacrococcygeal teratoma (SCT) is a relatively uncommon tumour, with a high risk of recurrence and metastasis. The factors associated with recurrence and metastatic disease were studied.A retrospective review was conducted of 173 children with SCT treated between January 1970 and February 2003 at the paediatric surgical centres in the Netherlands. Risk factors were identified by univariate and multivariate analysis.Eight children died shortly after birth or around the time of operation. Nine children, all over 18 months old, had metastases at presentation. Four teratomas with metastasis showed mature histology of the primar...
Source: British Journal of Surgery - October 24, 2006 Category: Surgery Authors: J. P. M. Derikx, A. De Backer, L. van de Schoot, D. C. Aronson, Z. J. de Langen, T. L. van den Hoonaard, N. M. A. Bax, F. van der Staak, L. W. E. van Heurn Source Type: journals
