Neoadjuvant Chemotherapy TherapyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Treatment outcome in patients undergoing surgery for carcinoma larynx and hypopharynx - a follow-up study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Compared with larynx cancers salvage rates are poorer for hypopharyngeal cancers and the role of primary surgery seems to be significantly higher and more decisive in overall survival (OS). Hypopharyngeal cancers therefore warrant a closer follow-up after an organ preservation protocol, to detect recurrence at the earliest stage and plan for an effective salvage surgery. Objective: To evaluate the survival and morbidity of patients treated by surgery for carcinoma of the larynx and hypopharynx according to site. Patients and methods: All patients who had undergone laryngectomy at the Division of Surgical Oncol...
Source: Acta Oto-Laryngologica - November 21, 2009 Category: ENT & OMF Authors: Varghese BT, Sebastian P, Mathew A Tags: Acta Otolaryngol Source Type: journals

Recurrence after neoadjuvant chemoradiation and surgery for esophageal cancer: Does the pattern of recurrence differ for patients with complete response and those with partial or no response?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Most esophageal cancer recurrences after neoadjuvant therapy and surgery are distant, and survival time after recurrence is short regardless of pathologic response. Fewer patients achieving complete response had recurrences, and distant recurrences in these patients manifest later than in patients showing partial response and those showing no response. Only pathologic response is significantly associated with disease recurrence, suggesting that tumor biology and chemosensitivity are critical in long-term patient outcome. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - November 20, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Robert A. Meguid, Craig M. Hooker, Joshua T. Taylor, Laurence R. Kleinberg, Stephen M. Cattaneo, Marc S. Sussman, Stephen C. Yang, Richard F. Heitmiller, Arlene A. Forastiere, Malcolm V. Brock Tags: General Thoracic Surgery Source Type: journals

[Advanced ovarian cancer: criteria of resectability.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Residual disease is the first predictive factor for survival in women with ovarian cancer. Neoadjuvant chemotherapy still has not proved superiority in terms of overall survival compared with complete initial resection. Hence, initial surgery remains the cornerstone of management for patients with advanced ovarian cancer. Various parameters have been proposed to evaluate the ability of complete resection. Clinical evaluation of peritoneal carcinomatosis and ascite is not relevant enough while general status (ASA score) is correlated with the risk of postoperative complications. Preoperative dosage of CA-125 higher than...
Source: Bulletin du Cancer - November 18, 2009 Category: Cancer & Oncology Authors: Chéreau E, Ballester M, Rouzier R, Coutant C, Daraï E Tags: Bull Cancer Source Type: journals

Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment StrategyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. From our data, postirradiation sarcoma should not be managed differently from primary sarcoma. Chemotherapy has to be included in the treatment plan of postirradiation sarcoma, in future studies. (Source: Sarcoma)
Source: Sarcoma - November 17, 2009 Category: Cancer & Oncology Source Type: journals

MRI Versus Ultrasonography And Mammography For Preoperative Assessment Of Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Accurate assessment of primary tumor size is an essential part of management in breast cancer patients. Tumor size is part of the TNM system used to stage breast cancer and provide prognostic information. Adaptation of the principles of breast conservation surgery requires evaluation of tumor size to judge appropriateness and extent of surgery. Precise measurement of tumor size is also important to monitor response to neoadjuvant chemotherapy for locally advanced tumors. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news

Randomized Clinical Trials in Gastric CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Minimally invasive resection has emerged as a surgical technique for gastric cancer, and there has been continued investigation to determine the appropriate extent of lymphadenectomy in gastric cancer patients. There has also been significant progress in evaluating the role of chemotherapeutic regimens used in the neoadjuvant and adjuvant settings for patients with resectable disease. We also summarize a selection of RCT trials focused on the perioperative care of the gastric cancer patient. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: James J. Mezhir, Venu G. Pillarisetty, Manish A. Shah, Daniel G. Coit Source Type: journals

An Update on Randomized Clinical Trials in Advanced and Metastatic Colorectal CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During the past eight years, there have been significant advances in the treatment and outcome of patients with metastatic colorectal cancer. This is likely the result of improved imaging, staging, chemotherapy, and surgery. After conducting a standardized MEDLINE literature search, this article reviews the prospective randomized controlled trials in advanced colorectal cancer published between May 2001 and October 2008. There are a total of 96 studies, all chemotherapy-related trials, divided into five categories based on trial focus: (1) types of chemotherapy; (2) administration of adjuvant or neoadjuvant chemotherapy fo...
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: Shishir K. Maithel, Michael I. D'Angelica Source Type: journals

Randomized Clinical Trials in Esophageal CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The treatment of esophageal cancer with curative intent remains highly controversial, with advocates of surgery alone, chemoradiotherapy alone, surgery with adjuvant therapy (including neoadjuvant and postoperative), and trimodality therapy each contributing prospective randomized controlled trials (PRCTs) to the body of scientific publications between 2000 and 2008. Any improvements in survival have been small in absolute percentage terms, and as such PRCTs published over the last decade have met the same primary obstacle encountered by the studies from the two prior decades, namely lack of power to detect small differenc...
Source: Surgical Oncology Clinics of North America - November 16, 2009 Category: Surgery Authors: Stephen A. Barnett, Nabil P. Rizk Source Type: journals

Neoadjuvant chemoradiation and pancreaticoduodenectomy for initially locally advanced head pancreatic adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PD after CRT was safe and resected patients had interesting survival rates. However, resected patients developed metastatic disease and new neoadjuvant regimens are needed to improve the survival of these patients. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: O. Turrini, F. Viret, L. Moureau-Zabotto, J. Guiramand, V. Moutardier, B. Lelong, M. Giovannini, J.R. Delpero Tags: Original Articles Source Type: journals

Influence of neoadjuvant radio-chemotherapy on tumor-infiltrating lymphocytes in squamous esophageal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Neoadjuvant RCT reduced the number of TILs in esophageal SCC. This was primarily seen in the centre of tumors and suggests that the effect of RCT on immunological response is located in the centre of tumors. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: U. Zingg, M. Montani, D.M. Frey, S. Dirnhofer, P. Went, D. Oertli Tags: Original Articles Source Type: journals

Pneumonectomy After Neoadjuvant Chemotherapy and Radiation for Advanced-Stage Lung CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Using a multidisciplinary team approach at a tertiary care center, pneumonectomy can be performed successfully after neoadjuvant chemotherapy and radiation for advanced-stage lung cancer. Vascularized flap for bronchial stump coverage may be important in this regard. Content Type Journal ArticleCategory Thoracic OncologyDOI 10.1245/s10434-009-0810-0Authors Thomas Ng, The Warren Alpert Medical School of Brown University Brown University Oncology Group Providence RI USAAriel E. Birnbaum, The Warren Alpert Medical School of Brown University Brown University Oncology Group Providence RI USAJac...
Source: Annals of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Systematic review of neoadjuvant transarterial chemoembolization for resectable hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Resection of hepatocellular carcinoma (HCC) offers the only hope for cure. However, in patients undergoing resection, recurrences, in particular, intrahepatic recurrence are common. The effectiveness of transarterial chemoembolization (TACE) as a neoadjuvant therapy for unresectable HCC was exploited by numerous liver units and employed preoperatively in the setting of resectable HCC with an aim to prevent recurrence and prolong survival. A systematic literature search of databases (Medline and PubMed) to identify published studies of TACE administered preoperatively as a neoadjuvant treatment for resectable HCC was undert...
Source: Liver International - November 14, 2009 Category: Gastroenterology Authors: Terence C. Chua, Winston Liauw, Akshat Saxena, Francis Chu, Derek Glenn, Alan Chai, David L. Morris Source Type: journals

Revisiting the prognostic value of preoperative 18F-fluoro-2-deoxyglucose (18F-FDG) positron emission tomography (PET) in early-stage (I & II) non-small cell lung cancers (NSCLC)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Each doubling of SUVmax as determined by preoperative PET is associated with a 1.28-fold increase in hazard of death in early-stage (I & II) NSCLC. Preoperative SUVmax is not an independent predictor of overall survival. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-009-1291-xAuthors Mohit Agarwal, Oakland University William Beaumont School of Medicine Hospital Department of Internal Medicine 3601 W 13 Mile Rd Royal Oak MI 48073-6769 USAGovinda Brahmanday, Oakland University William Beaumont School of Medicine Hospital Department of Internal Medicine 3601 W 13 Mile ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - November 13, 2009 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

The Christie Experience of Neoadjuvant Chemotherapy for Invasive Bladder Cancer. Tolerance, Short Term Response and Time to Definitive TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aim/introduction: Neoadjuvant chemotherapy in muscle-invasive bladder cancer has demonstrated a 5% improvement in absolute overall survival (OS) at 5 years. This retrospective study addressed the tolerance and response to this approach. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: B. Jyoti, C. Chan, D. Corgie, A. Choudhury, J. Wylie Tags: Abstracts Source Type: journals

EUS diagnosis of a primary pancreatic metastasis of alveolar rhabdomyosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: To our knowledge this is the first reported case of EUS guided FNA diagnosis of alveolar rhabdomyosarcoma metastatic to the pancreas. This is also the only case report of a primary pancreatic metastasis of this type of tumor in a male patient (which occurs less commonly than in females). PMID: 19890194 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Vanwoerkom RC, Bentz J, Chen L, Adler DG Tags: JOP Source Type: journals

Some reflexions on the modified Appleby procedure.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: CT vascular encasement is not always synonymous with real tumoral vascular invasion. Improvement in the quality of anesthesiological and surgical techniques has allowed vascular resections with lower morbidity. A cholecystectomy should always be performed using the modified Appleby procedure. PMID: 19890192 [PubMed - in process] (Source: JOP)
Source: JOP - November 8, 2009 Category: Gastroenterology Authors: Morera-Ocon FJ, Cárcel-Cárcel I, Ballestín Vicente J, Iranzo González-Cruz V Tags: JOP Source Type: journals

Surgical Management of Colorectal Liver MetastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinics in Colon and Rectal Surgery 2009; 22: 225-232DOI: 10.1055/s-0029-1242462ABSTRACTColorectal cancer is the third most commonly diagnosed cancer with approximately half of the patients developing liver metastases during the course of their disease. Modern multimodal therapies have improved the overall survival. Liver resection remains the most important modality in the treatment of colorectal liver metastases. The evolution of the criteria for resectability has resulted in more patients being offered a hepatectomy. This is further augmented with the utilization of adjuncts to liver resection, including portal vein emb...
Source: Clinics in Colon and Rectal Surgery - November 7, 2009 Category: Surgery Source Type: journals

Neoadjuvant chemotherapy with a combination of docetaxel, cisplatin, fluorouracil, and leucovorin in nonresectable advanced gastric cancer: a short communicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this study was to evaluate the efficacy and toxicity of docetaxel (TAX), cisplatin (CDDP), and fluorouracil (5-FU) plus leucovorin (CF) as the neoadjuvant chemotherapy (NACT) regimens in the treatment of nonresectable advanced gastric cancer. Twelve patients with nonresectable advanced gastric cancer were treated with NACT regimens consisted of docetaxel, cisplatin, fluorouracil, plus leucovorin before operation. Nine of the 12 patients were downstaged and 8 were radically operated after the end of the NACT. The overall response rate was 75% with 8.3% complete response and 66.7% partial r...
Source: Medical Oncology - November 3, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Noninvasive Imaging Surrogate of Angiogenesis in OsteosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests an important role of DCE-MRI as a noninvasive imaging surrogate of tumor angiogenesis in osteosarcoma based on visual inspection of TIC. Pediatr Blood Cancer. © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 3, 2009 Category: Cancer & Oncology Authors: Jyoti Bajpai, Shivanand Gamanagatti, Mehar C. Sharma, Rakesh Kumar, Sreenivas Vishnubhatla, Shah Alam Khan, Shishir Rastogi, Arun Malhotra, Sameer Bakhshi Source Type: journals

Editorial CommentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with invasive upper tract transitional cell carcinoma (UTTCC) pose a difficult management problem with prognosis dependent on the degree of invasion, the relationship, if any, to previous superficial or invasive bladder cancer, and the presence of metastatic nodes. Similar to invasive bladder cancer, preoperative staging can often be inaccurate and distinguishing superficial invasion from deep invasion may not always be possible. Unlike invasive bladder cancer, strategies to improve survival rates using neoadjuvant systemic chemotherapy before nephroureterectomy have not been subjected to clinical trials. However,...
Source: Urology - November 1, 2009 Category: Urology & Nephrology Authors: Paul Russo Tags: Oncology Source Type: journals

[Analysis of postoperative morbidity in patients with gastric adenocarcinoma treated using a protocol of preoperative chemoradiotherapy and surgery.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Preoperative treatment with chemoradiotherapy in patients with locally advanced stomach cancer does not increase the incidence of post-surgical complication. The preoperative condition of the patient (BMI) and extending the surgery to the spleen and pancreas are prognostic factors of early postoperative complications. PMID: 19880100 [PubMed - as supplied by publisher] (Source: Cirugia eEspanola)
Source: Cirugia eEspanola - October 30, 2009 Category: Surgery Authors: Valentí V, Hernández-Lizoain JL, Martínez Regueira F, Gil A, Martí P, Zozaya G, Bueno A, Pedano N, Arredondo J, Beorlegui MC, Alvarez-Cienfuegos J Tags: Cir Esp Source Type: journals

Preoperative Multimodality Therapy Improves Disease-Free Survival in Patients With Carcinoma of the Rectum: NSABP R-03 [Gastrointestinal Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Preoperative chemoradiotherapy, compared with postoperative chemoradiotherapy, significantly improved DFS and showed a trend toward improved OS. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Roh, Colangelo, O'Connell, Yothers, Deutsch, Allegra, Kahlenberg, Baez-Diaz, Ursiny, Petrelli, Wolmark Tags: chemotherapy Gastrointestinal Cancer Source Type: journals

Diagnostic performance of fluorodeoxyglucose-positron emission tomography/computed tomography of breast cancer in detecting axillary lymph node metastasis: comparison with ultrasonography and contrast-enhanced CTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions PET/CT showed poor sensitivity and high specificity in the detection of axillary lymph node metastasis of breast cancer. Diagnostic performance of PET/CT was not superior to that of ultrasonography and contrast-enhanced CT. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12149-009-0314-9Authors Shuichi Monzawa, Hyogo Cancer Center Department of Radiology Kitaohji 13-70 Akashi Hyogo 673-8558 JapanShuji Adachi, Hyogo Cancer Center Department of Radiology Kitaohji 13-70 Akashi Hyogo 673-8558 JapanKayo Suzuki, Hyogo Cancer Center Department of Radiology Kitaohji 13-70 Akashi H...
Source: Annals of Nuclear Medicine - October 29, 2009 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: journals

Concordant Gene Expression Signatures Predict Clinical Outcomes of Cancer Patients Undergoing Systemic TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conventional development of multivariate gene expression models (GEM) predicting therapeutic response of cancer patients is based on analysis of patients treated with specific regimens, which limits generalization to different or novel drug combinations. We overcome this limitation by developing GEMs based on in vitro drug sensitivities and microarray analyses of the NCI-60 cancer cell line panel. These GEMs were evaluated in blind fashion as predictors of tumor response and/or patient survival in seven independent cohorts of patients with breast (n = 275), bladder (n = 59), and ovarian (n= 143) cancer treated with multiag...
Source: Cancer Research - October 29, 2009 Category: Cancer & Oncology Authors: Williams, P. D., Cheon, S., Havaleshko, D. M., Jeong, H., Cheng, F., Theodorescu, D., Lee, J. K. Tags: Clinical Research Source Type: journals

Thymidine phosphorylase to dihydropyrimidine dehydrogenase ratio as a predictive factor of response to preoperative chemoradiation with capecitabine in patients with advanced rectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To identify if thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and ratio TP/DPD levels in tumor tissues are potential predictive factors for response to combined preoperative chemoradiation with capecitabine, in patients with locally advanced rectal cancer (LARC).Between 2004 and 2006, 28 patients with LARC (cT2-T4, N0-N2) were treated with neoadjuvant chemoradiation. Total radiation dose was 50.4 Gy and daily dose was 1.8 Gy in 5.5 weeks. Capecitabine was administrated 1,650 mg/m2/day, 7 days/week. Preoperative staging was based on combined computer tomography and endorectal ultrasound. Tissue samples...
Source: Journal of Surgical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: C.S. Boskos, C. Liacos, D. Korkolis, K. Aygerinos, I. Lamproglou, E. Terpos, E. Stoupa, G. Baltatzis, K. Beroukas, P. Papasavvas, M.A. Dimopoulos, A. Bamias Source Type: journals

The role of PET CT to evaluate the response to neoadjuvant chemotherapy in advanced breast cancer: Comparison with ultrasonography and magnetic resonance imagingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is aimed to estimate the predictive role of PET CT and other imaging modalities (ultrasound, MRI) through NAC.PET CT was acquired before and after NAC from 41 patients. Pathologic results were classified as pathological complete response (pCR) and non-pCR. The results of clinical responses were assessed with imaging indexes (postTx, postchemotherapy size or peak standardized uptake values (pSUV); delta, the size difference between treatment; RR, reduction rate of tumor size or pSUV), and they were compared with pathologic results.Seven patients (17.1%) showed pCR. As a result of comparison of the image index, al...
Source: Journal of Surgical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Jae Hyuck Choi, Hye In Lim, Se Kyung Lee, Wan Wook Kim, Sang Min Kim, EunYoon Cho, Eun Young Ko, Boo-Kyung Han, Yeon Hee Park, Jin-Seok Ahn, Young-Hyuck Im, Jeong Eon Lee, Jung-Hyun Yang, Seok Jin Nam Source Type: journals

Rectal cancer: quo vadis, neoadjuvant and adjuvant (chemo) radiotherapy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Invited CommentaryDOI 10.1007/s00384-009-0825-9Authors Rainer Fietkau, University of Erlangen Department of Radiotherapy Erlangen Germany Journal International Journal of Colorectal DiseaseOnline ISSN 1432-1262Print ISSN 0179-1958 (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - October 26, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals

Successful treatment of neoadjuvant therapy for papillary tumor of the pineal regionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a boy who in 1994, at the age of 11, presented with headache and vomiting. The fi nal diagnosis was papillary tumor of the pineal region (PTPR). Magnetic resonance imaging (MRI) revealed a heterogeneous mass. Hydrocephalus was addressed by immediate ventricle drainage; subsequently, we attempted tumor removal. As the intraoperative diagnosis of the hemorrhagic tumor was primitive neuroectodermal tumor (PNET), we did not proceed to total removal. After the delivery of radiotherapy (50.4 Gy) and one course of Nimustine hydrochloride (ACNU) chemotherapy, the residual tumor was completely resected. The diagnosis ...
Source: Brain Tumor Pathology - October 26, 2009 Category: Neurology Tags: Brain Tumor Pathology Source Type: journals

Chemoradiotherapy for cancer of the esophagus: contribution of the leucovorin, 5-fluorouracil bolus, and infusion–cisplatin–radiotherapy schedule starting with two neoadjuvant chemotherapy cycles: results from a pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To assess feasibility and tolerance of a modification in the usual radiochemotherapy regimen for esophageal cancer by using a leucovorin, 5-fluorouracil bolus, and infusion[ndash]cisplatin regimen (six cycles), beginning with two cycles of chemotherapy before conventional radiotherapy (50 Gy), 33 patients, 30 were men, 62.8 ± 9.5 years, were treated for an esophageal carcinoma (29 squamous cell), 27 of these were in stage III (based on computed tomography scan). Neoadjuvant chemotherapy was well tolerated; concomitant radiochemotherapy was associated with severe adverse events mostly hematological in 23 patients. Complete...
Source: Diseases of the Esophagus - October 26, 2009 Category: Gastroenterology Authors: T. N. Tran Vuong, E. Le Prisé, E. Vauléon, E. Boucher, O. Audrain, J.-L. Raoul Source Type: journals

Cardiac safety of trastuzumab as adjuvant treatment for Japanese patients with early breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The incidence of cardiac events caused by trastuzumab treatment was low in our analysis. Adjuvant trastuzumab treatment for up to at least 1 year should be safe for Japanese breast cancer patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-009-0898-zAuthors Mikiya Ishihara, National Cancer Center Hospital East Division of Oncology/Hematology 6-5-1 Kashiwanoha, Kashiwa Chiba 277-8577 JapanHirofumi Mukai, National Cancer Center Hospital East Division of Oncology/Hematology 6-5-1 Kashiwanoha, Kashiwa Chiba 277-8577 JapanShunji Nagai, National Cancer Center Hospital...
Source: International Journal of Clinical Oncology - October 24, 2009 Category: Cancer & Oncology Tags: International Journal of Clinical Oncology Source Type: journals

Systematic Review of Randomized and Nonrandomized Trials of the Clinical Response and Outcomes of Neoadjuvant Systemic Chemotherapy for Resectable Colorectal Liver MetastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Current evidence suggests that objective response to neoadjuvant chemotherapy may be achieved with improvement in DFS in patients with resectable CLM. A prospective randomized trial of neoadjuvant therapy versus adjuvant therapy after liver resection is required to determine the optimal perisurgical treatment regimen. Content Type Journal ArticleCategory Hepatobiliary TumorsDOI 10.1245/s10434-009-0781-1Authors Terence C. Chua, University of New South Wales Department of Surgery, St George Hospital Kogarah Sydney AustraliaAkshat Saxena, University of New South Wales Department of Surgery, St...
Source: Annals of Surgical Oncology - October 24, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

A Systematic Review of Resectability and Survival After Concurrent Chemoradiation in Primarily Unresectable Pancreatic CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The finding of a high proportion of R0 resection among all resections performed confirms the activity of neoadjuvant radiochemotherapy and should not be neglected. Based on these data, patients with unresectable pancreatic cancer without disease progression after chemoradiotherapy should be considered for radical surgery. Content Type Journal ArticleCategory Radiation OncologyDOI 10.1245/s10434-009-0762-4Authors Alessio G. Morganti, Catholic University Department of Radiation Oncology, “John Paul II” Center for High Technology Research and Education in Biomedical Sciences Campobasso It...
Source: Annals of Surgical Oncology - October 24, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Study Finds No Relationship Between PCR Rate And Race In Women With Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Locally advanced breast cancer patients who received the same class of neoadjuvant chemotherapy were found to have no evidence of disease at the time of their surgery, or achieved pathological complete response, at the same rate regardless of race, according to researchers at The University of Texas M. D. Anderson Cancer Center. (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - October 24, 2009 Category: Cancer & Oncology Source Type: news

Neoadjuvant Capecitabine Added to Standard Treatment Helps to Eradicate Tumors in PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Data from the Austrian Breast and Colorectal Cancer Study Group (ABCSG)-24 study presented at the joint 15th ECCO and 34th ESMO congress in Berlin, show that adding capecitabine (Xeloda) to anthracycline- and taxane-containing regimens prior to surgery completely eradicated the tumor in 24% of women with HER2-positive or HER2-negative early breast cancer. This is an impressive finding since the proportion of women achieving total tumor eradication with standard chemotherapy for HER2-positive or HER2-negative early breast cancer is less than 20% (range = 6%–18%). (Source: Cancer Network)
Source: Cancer Network - October 23, 2009 Category: Cancer & Oncology Source Type: info

Primary chemotherapy patterns for ovarian cancer treatment in JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Adherence to standardized chemotherapy was comparable to rates in European countries, although rates among hospitals differed significantly. Elderly patients were more likely to receive divided-dose regimens. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - October 22, 2009 Category: OBGYN Authors: Takako Shirai, Yuichi Imanaka, Miho Sekimoto, Tatsuro Ishizaki Tags: Clinical Investigations Source Type: journals

Short-term outcomes of laparoscopic total mesorectal excision following neoadjuvant chemoradiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In our experience, laparoscopic TME for mid and lower rectal cancer is feasible and safe. Patients benefit from the short-term advantages of laparoscopy, including shorter length of hospital stay, time to tolerating a regular diet, and time to first bowel movement or stoma function. Although there were no short-term differences in oncologic parameters, the long-term oncologic outcome requires further investigation. Content Type Journal ArticleDOI 10.1007/s00464-009-0702-1Authors P. Denoya, Cleveland Clinic Blvd Department of Colorectal Surgery 2950 Weston Fl 33331 USAH. Wang, Cleveland Cl...
Source: Surgical Endoscopy - October 22, 2009 Category: Surgery Tags: Surgical Endoscopy Source Type: journals

Is carcinoma in situ (cis), a contra-indication for neoadjuvant chemotherapy for Transitional Cell Carcinoma (TCC) of the bladder?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Neoadjuvant chemotherapy has been combined with radical cystectomy to improve survival from occult metastatic disease. The purpose of this study was to evaluate disease response to neoadjuvant Gemcitabine and Cisplastin chemotherapy in muscle-invasive TCC compared to muscle-invasive TCC with CIS. (Source: British Journal of Medical and Surgical Urology)
Source: British Journal of Medical and Surgical Urology - October 22, 2009 Category: Urology & Nephrology Authors: M.S. Ahmad, J. Cresswell, N. Umer Eronini, J.E. Whiteway, A.C. Thorpe Tags: Abstracts Source Type: journals

Thrombotic microangiopathy following docetaxel and trastuzumab chemotherapy: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 47-year-old patient with localised breast cancer who developed thrombotic microangiopathy (HUS/TTP) acutely following concurrent neoadjuvant therapy with trastuzumab and docetaxel. We demonstrate from our case that mild confusion occurring on a background of mild anaemia and thrombocytopenia may sometimes be the only clue to the diagnosis. Clinicians should be aware of the possibility of thrombotic microangiopathy associated with trastuzumab and docetaxel therapy, as early intervention can improve clinical outcome. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9333-6Authors ...
Source: Medical Oncology - October 22, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Detection of >/=1 CTC/7.5 ml before neoadjuvant chemotherapy can accurately predict OS. Our findings may change the clinical management of nonmetastatic breast cancer and indicate that the metastatic efficiency of CTC could be higher than previously reported. PMID: 19850639 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 22, 2009 Category: Cancer & Oncology Authors: Bidard FC, Mathiot C, Delaloge S, Brain E, Giachetti S, de Cremoux P, Marty M, Pierga JY Tags: Ann Oncol Source Type: journals

Retrospective analysis of 119 Chinese noninflammatory locally advanced breast cancer cases treated with intravenous combination of vinorelbine and epirubicin as a neoadjuvant chemotherapy: a median follow-up of 63.4 monthsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is a retrospective evaluation of the efficacy of neoadjuvant chemotherapy (NC) with a vinorelbine (V) and epirubicin (E) intravenous combination regimen and is aimed at identification of predictive markers for the long-term outcome in noninflammatory locally advanced breast cancer (NLABC). Methods: One-hundred-and-nineteen patients with NLABC were identified from September 2001 to May 2006. Analysis was performed in March 2008, with a median follow-up of 63.4 months (range, 9-76 months). All patients were diagnosed with invasive breast cancer using 14G core needle biopsy and treated with three cycles of VE befor...
Source: BMC Cancer - October 20, 2009 Category: Cancer & Oncology Authors: Ou HuangCanMing ChenJiaYi WuShuJie ChenXiaoSong ChenGuangYu LiuZhen HuJingSong LuJiong WuZhiMin ShaoZhenZhou ShenKunWei Shen Source Type: journals

Stage-for-stage comparison of definitive chemoradiotherapy, surgery alone and neoadjuvant chemotherapy for oesophageal carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Definitive chemoradiotherapy (dCRT) has been proposed as an alternative therapy for selected patients with oesophageal cancer. The aim of this study was to determine the outcomes of dCRT, surgery alone, and neoadjuvant chemotherapy followed by surgery (CS) in patients with oesophageal cancer.Consecutive patients diagnosed with oesophageal cancer and managed by a multidisciplinary team were staged by computed tomography and endoluminal ultrasonography. Those deemed unsuitable for surgery on the grounds of performance status, bulky local disease or personal choice received dCRT. The primary outcome measure was overall surviv...
Source: British Journal of Surgery - October 20, 2009 Category: Surgery Authors: M. A. Morgan, W. G. Lewis, A. Casbard, S. A. Roberts, R. Adams, G. W. B. Clark, T. J. Havard, T. D. L. Crosby Tags: Original Articles Source Type: journals

Effect of neoadjuvant chemoradiotherapy on prognosis and surgery for esophageal carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Compared with surgery alone, neoadjuvant chemoradiotherapy can improve the long-term survival and reduce local-regional cancer recurrence. Concurrent administration of neoadjuvant chemoradiotherapy was superior to sequential chemoradiotherapy. PMID: 19842230 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 20, 2009 Category: Gastroenterology Authors: Lv J, Cao XF, Zhu B, Ji L, Tao L, Wang DD Tags: World J Gastroenterol Source Type: journals

Stage-for-stage comparison of definitive chemoradiotherapy, surgery alone and neoadjuvant chemotherapy for oesophageal carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION:: These findings support the need for a randomized trial of dCRT versus CS for resectable oesophageal cancer. Copyright (c) 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. PMID: 19847875 [PubMed - as supplied by publisher] (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - October 20, 2009 Category: Surgery Authors: Morgan MA, Lewis WG, Casbard A, Roberts SA, Adams R, Clark GW, Havard TJ, Crosby TD Tags: Br J Surg Source Type: journals

Expression and Significance of bag-1, bcl-2 in Non-small Cell Lung Cancer and the Correlation with Multi-drug ResistanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The high expression of bag-1, bcl-2 protein and the low expression of bax protein exist in nonsmall cell lung cancer. The expression level of bag-1 protein is closely related to the differentiation degree of non-small cell lung cancer. A highly positive correlation exists between bag-1 and bcl-2 expression, and a highly negative correlation is observed between bcl-2 and bax expression. The study doesn’t provide the evidence that there is a close correlation between the expression levels of bag-1, bcl-2, bax and the multi-drug resistance in non-small cell lung cancer. (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - October 19, 2009 Category: Cancer & Oncology Source Type: journals

The Clinical Application of Video Mediastinoscopy and CT in the N Staging of Preoperative Lung CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion VM is superior to CT in the diagnosis of N staging of preoperative lung cancer; Due to its safety and effectiveness, VM will be wildly used in the field of thoracic surgery. (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - October 19, 2009 Category: Cancer & Oncology Source Type: journals

Sentinel Lymph Node Surgery After Neoadjuvant Chemotherapy Is Accurate and Reduces the Need for Axillary Dissection in Breast Cancer PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study of 3746 women with node-negative T1-T3 breast cancer, sentinel lymph node surgery after neoadjuvant chemotherapy had similar detection rates and false-negative rates when compared with surgery... Objective:... (Source: OncologySTAT Journal Scans)
Source: OncologySTAT Journal Scans - October 17, 2009 Category: Cancer & Oncology Source Type: journals

Impact of Preoperative Bevacizumab on Complications After Resection of Colorectal Liver Metastases: Case-Matched Control StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions No impact on the incidence or severity of complications by bevacizumab could be shown. Bevacizumab may even reduce the incidence of liver failure after liver surgery. Content Type Journal ArticleDOI 10.1007/s00268-009-0251-8Authors Mahfud Mahfud, University Hospital Zurich Department of Surgery, Swiss HPB (Hepato-Pancreatico-Biliary) Center Raemistrasse 100 8091 Zurich SwitzerlandStefan Breitenstein, University Hospital Zurich Department of Surgery, Swiss HPB (Hepato-Pancreatico-Biliary) Center Raemistrasse 100 8091 Zurich SwitzerlandAshraf Mohammad El-Badry, University Hospital Zurich Depa...
Source: World Journal of Surgery - October 17, 2009 Category: Surgery Tags: World Journal of Surgery Source Type: journals

Phase II, Randomized, Placebo-Controlled Trial of Neoadjuvant Celecoxib in Men With Clinically Localized Prostate Cancer: Evaluation of Drug-Specific Biomarkers [Genitourinary Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Treatment with 4 to 6 weeks of celecoxib had no effect on intermediate biomarkers of prostate carcinogenesis, despite the achievement of measurable tissue levels. We caution against using celecoxib 400 mg twice daily as a preventive agent for prostate cancer in additional studies. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Antonarakis, Heath, Walczak, Nelson, Fedor, De Marzo, Zahurak, Piantadosi, Dannenberg, Gurganus, Baker, Parnes, DeWeese, Partin, Carducci Tags: Clinical Trials, chemoprevention studies, Surgery, Genitourinary Genitourinary Cancer Source Type: journals

Effect of neoadjuvant chemotherapy on oestrogen, progesterone and HER 2 receptor expression in breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction: Neoadjuvant chemotherapy (NC) is used in treating locally advanced operable breast cancer. After surgery, further adjuvant treatment is offered based on the estrogen receptor(ER), progesterone receptor(PR) and HER2 status of the core biopsy taken preoperatively. However a change in ER/PR or HER2 status following NC could have profound effect on adjuvant treatment. The aim of our study was to determine the percentage of patients whose ER/PR, HER2 receptor expression change with NC and if these changes lead to change in their adjuvant treatment. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Tapan Sircar, S. Chaudhry, A. Francis Tags: Abstracts Source Type: journals

Locally Recurrent Rectal Cancer: Prognostic Factors and Long-Term Outcomes of Multimodal TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Surgical resection still remains the most important therapeutic and prognostic factor for patients with locally recurrent rectal cancer. Multimodal treatments can be safely performed by an experienced team in referral tertiary centers and can result in a safer outcome, better local disease control, and even long-term survival in carefully selected patients. Content Type Journal ArticleCategory Colorectal CancerDOI 10.1245/s10434-009-0737-5Authors Fabio Pacelli, Catholic University of Rome, “A. Gemelli” Hospital Department of Digestive Surgery Rome ItalyAntonio P. Tortorelli, Catholic U...
Source: Annals of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals