Neoadjuvant Radiation Therapy This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest news and research items in this category.

Androgen deprivation for prostate cancer.
Abstract Androgen deprivation therapy (ADT) is the mainstay systemic treatment of prostate cancer because of the androgen dependence of the disease. Although ADT has long been used to manage prostate cancer, its use continues to evolve as data from clinical trials mature and long-term effects are recognized. For patients with localized disease and high-risk features, short and long courses of ADT as neoadjuvant/adjuvant therapy have been shown to improve survival when used with radiation therapy, but this has not been demonstrated with radical prostatectomy. The role of ADT with salvage radiotherapy after radical p...
Source: Clinical Prostate Cancer - June 16, 2013 Category: Cancer & Oncology Authors: Chi KN, Nguyen PL, Higano CS Tags: Am Soc Clin Oncol Educ Book Source Type: research

The Role of Chemotherapy in the Management of Stage IIIA Non-Small Cell Lung Cancer.
Abstract Patients with confirmed stage IIIA non-small cell lung cancer (NSCLC) represent a very heterogeneous group which includes those with limited microscopic ipsilateral mediastinal lymph node involvement discovered after a surgical resection, as well as those who have radiologically evident bulky subcarinal lymph node involvement at presentation. Different therapeutic options in stage IIIA disease include neoadjuvant chemo- or chemoradiotherapy followed by surgery, primary surgery followed by adjuvant chemotherapy with or without sequential adjuvant radiation therapy or definitive chemoradiation without surger...
Source: Clinical Lung Cancer - June 12, 2013 Category: Cancer & Oncology Authors: Baik CS, Vallières E, Martins RG Tags: Am Soc Clin Oncol Educ Book Source Type: research

Radiation Therapy and Esophageal CancerRadiation Therapy and Esophageal Cancer
Neoadjuvant chemoradiotherapy followed by surgical resection is the current standard of care for localized cancer of the esophagus. What's on the horizon? Cancer Control: Journal of the Moffitt Cancer Center (Source: Medscape Radiology Headlines)
Source: Medscape Radiology Headlines - June 3, 2013 Category: Radiology Tags: Hematology-Oncology Journal Article Source Type: news

Status of Sentinel Lymph Node for Breast Cancer
This article highlights the overall survival and disease-free survival data as reported from the clinical trials. This article also reviews the status of SLN procedures and the following: male breast cancer, the roles of various imaging modalities (single-photon emission computed tomography/computed tomography, positron emission tomography/computed tomography, and ultrasound), ductal carcinoma in situ, extra-axillary SLNs, SLNB after neoadjuvant chemotherapy, radiation exposure to patients and medical personnel, and a new radiotracer that is the first to label SLNs not by particle trapping but by specific macrophage recept...
Source: Seminars in Nuclear Medicine - June 3, 2013 Category: Radiology Authors: Valeria M. Moncayo, John N. Aarsvold, Sandra F. Grant, Scott C. Bartley, Naomi P. Alazraki Source Type: research

[Radiation therapy in thyroid cancer].
Abstract Anaplastic thyroid cancers represent 1-2% of all thyroid tumours and are of very poor prognosis even with multimodality treatment including external beam radiation therapy. Conversely, differentiated thyroid carcinomas (at least 80% of thyroid cancers) hamper good prognosis with surgery with or without radioiodine and there is hardly any room for external beam radiation therapy. Insular and medullar carcinomas have intermediary prognosis and are rarely irradiated. We aimed to update recommendations for external beam irradiation in these different clinical situations and put in light the benefits of new irr...
Source: Cancer Radiotherapie - June 1, 2013 Category: Cancer & Oncology Authors: Sun XS, Guevara N, Fakhry N, Sun SR, Marcy PY, Santini J, Bosset JF, Thariat J Tags: Cancer Radiother Source Type: research

Population-based validation of a policy change to use long-term androgen deprivation therapy for cT3-4 prostate cancer: Impact of the EORTC22863 and RTOG 85-31 and 92-02 trials.
CONCLUSIONS: This population-based study demonstrated improved overall survival following a policy change to use of prolonged ADT with curative RT for patients with T3-T4 prostate cancer. PMID: 23726114 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 29, 2013 Category: Radiology Authors: Tran E, Paquette M, Pickles T, Jay J, Hamm J, Liu M, Lim J, Keyes M, Kwan W, Tyldesley S Tags: Radiother Oncol Source Type: research

A multi‐institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer
CONCLUSIONSPreoperative therapy with full‐dose gemcitabine, oxaliplatin, and RT was feasible and resulted in a high percentage of R0 resections. The current results are particularly encouraging, because the majority of patients had borderline resectable disease. Cancer 2013. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - May 29, 2013 Category: Cancer & Oncology Authors: Edward J. Kim, Edgar Ben‐Josef, Joseph M. Herman, Tanios Bekaii‐Saab, Laura A. Dawson, Kent A. Griffith, Isaac R. Francis, Joel K. Greenson, Diane M. Simeone, Theodore S. Lawrence, Daniel Laheru, Christopher L. Wolfgang, Terence Williams, Mark Bloomst Tags: Original Article Source Type: research

A phase II trial of neoadjuvant IMRT-based chemoradiotherapy followed by one cycle of capecitabine for stage II/III rectal adenocarcinoma
Conclusions: Our study indicates that neoadjuvant chemoradiation followed by one cycle of capecitabine before surgery has a good treatment efficacy, with only mild toxicities associated with chemoradiation and acceptable surgical complications. Treatment response was an early surrogate marker and correlated to oncologic prognosis. (Source: Radiation Oncology)
Source: Radiation Oncology - May 29, 2013 Category: Cancer & Oncology Authors: Ji ZhuWeilie GuPeng LianWeiqi ShengGang CaiDebing ShiSanjun CaiZhen Zhang Source Type: research

Neoadjuvant-intensified treatment for rectal cancer: Time to change?
CONCLUSION: The results of this study suggest oxaliplatin chemotherapy has a beneficial effect on overall survival, likely due to an increase in local tumor control. PMID: 23716984 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 28, 2013 Category: Gastroenterology Authors: Musio D, De Felice F, Bulzonetti N, Guarnaccia R, Caiazzo R, Bangrazi C, Raffetto N, Tombolini V Tags: World J Gastroenterol Source Type: research

[Palliative Plastic Surgery in Multidisciplinary Therapeutic Concepts.]
Discussion: Opportunities and limitations in plastic and reconstructive surgery should be continuously presented in tumour boards, to clarify these important procedures for palliative patients to all members of the tumour board. There is an increasing impact of plastic surgery for improving the quality of life in palliative patients in a multimodal therapeutical concept. PMID: 23696204 [PubMed - as supplied by publisher] (Source: Zentralblatt fur Chirurgie)
Source: Zentralblatt fur Chirurgie - May 21, 2013 Category: Surgery Authors: Kippenhan T, Hirche C, Lehnhardt M, Daigeler A Tags: Zentralbl Chir Source Type: research

Dose-volumetric parameters and prediction of severe acute esophagitis in patients with locally-advanced non small-cell lung cancer treated with neoadjuvant concurrent hyperfractionated-accelerated chemoradiotherapy
Conclusion: Increase of absolute oesophageal volume included in the 95%-isodose correlates with severity of acute esophagitis in LA-NSCLC patients treated with neo-adjuvant concurrent HA-CRT. (Source: Radiation Oncology)
Source: Radiation Oncology - May 17, 2013 Category: Cancer & Oncology Authors: Farkhad ManapovSusanna SepeMaximilian NiyaziClaus BelkaGodehard FriedelWilfried Budach Source Type: research

Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers.
CONCLUSION: These results warrant further investigation into the possible clinical benefit of CD44+/CD24- as a predictive marker in EC patients for the response to chemoradiation. PMID: 23684587 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 14, 2013 Category: Radiology Authors: Smit JK, Faber H, Niemantsverdriet M, Baanstra M, Bussink J, Hollema H, van Os RP, Plukker JT, Coppes RP Tags: Radiother Oncol Source Type: research

From the Radiologic Pathology Archives: Ewing Sarcoma Family of Tumors: Radiologic-Pathologic Correlation [Musculoskeletal Imaging]
The Ewing sarcoma family of tumors includes osseous Ewing sarcoma, extraskeletal Ewing sarcoma, primitive neuroectodermal tumor, and Askin tumor. They share a karyotype abnormality with translocation involving chromosomes 11 and 22. Histologically, these lesions demonstrate crowded sheets of small round blue cells. Imaging features of osseous Ewing sarcoma often suggest the diagnosis, with aggressive long-bone destruction in the metadiaphysis of an adolescent or young adult and an associated soft-tissue mass. Focal areas of cortical destruction are frequent, allowing continuity between the intraosseous and extraosseous com...
Source: Radiographics recent issues - May 14, 2013 Category: Radiology Authors: Murphey, M. D., Senchak, L. T., Mambalam, P. K., Logie, C. I., Klassen-Fischer, M. K., Kransdorf, M. J. Tags: Magnetic Resonance Imaging, Musculoskeletal Radiology, Pediatric Radiology, Oncologic Imaging Musculoskeletal Imaging Source Type: research

Stereotactic body radiotherapy for localized prostate cancer: disease control and quality of life at 6 years
Conclusions: In this large series with long-term follow-up, we found excellent biochemical control rates and low and acceptable toxicity, outcomes consistent with those reported for from high dose rate brachytherapy (HDR BT). Provided that measures are taken to account for prostate motion, SBRT's distinct advantages over HDR BT include its noninvasiveness and delivery to patients without anesthesia or hospitalization. (Source: Radiation Oncology)
Source: Radiation Oncology - May 13, 2013 Category: Cancer & Oncology Authors: Alan KatzMichael SantoroFred DiblasioRichard Ashley Source Type: research

In Regard to Jakobsen et al
To the Editor: I congratulate Jakobsen et al for the first randomized clinical study of dose escalation during neoadjuvant chemoradiation for rectal adenocarcinoma. Several important details warrant discussion. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - May 6, 2013 Category: Radiology Authors: Zsolt Fekete Tags: Comments Source Type: research

[Tolerance and efficacy of preoperative radiation therapy for elderly patients treated for rectal cancer.]
CONCLUSION: Neoadjuvant treatment is feasible with encouraging survival rates for patients aged 70 years and older. Short scheme radiation therapy seems to be an interesting option in this population. PMID: 23643361 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - May 2, 2013 Category: Cancer & Oncology Authors: Le Fur E, Chatellier G, Berger A, Emile JF, Dousset B, Nordlinger B, Berges O, Deberne M, Dessard-Diana B, Henni M, Giraud P, Housset M, Durdux C Tags: Cancer Radiother Source Type: research

Stage IIIA Non-Small Cell Lung Cancer: Morbidity and Mortality of Three Distinct Multimodality Regimens [ORIGINAL ARTICLES: GENERAL THORACIC]
Conclusions Chemoradiotherapy carries a significant morbidity profile. However, high-dose neoadjuvant radiation is not associated with increased postoperative morbidity or mortality relative to standard-dose radiation in patients selected for anatomic resection. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - April 30, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Seder, C. W., Allen, M. S., Cassivi, S. D., Deschamps, C., Nichols, F. C., Olivier, K. R., Shen, K. R., Wigle, D. A. Tags: Lung - cancer ORIGINAL ARTICLES: GENERAL THORACIC Source Type: research

Vascular endothelial growth factor (VEGF) expression in locally advanced prostate cancer: secondary analysis of radiation therapy oncology group (RTOG) 8610
Conclusions: This study revealed no statistically significant prognostic or predictive value of VEGF expression for locally advanced prostate cancer. This analysis is among one of the largest sample bases with long-term follow-up in a well-characterized patient population. There is an urgent need to establish multidisciplinary initiatives for coordinating further research in the area of human prostate cancer biomarkers. (Source: Radiation Oncology)
Source: Radiation Oncology - April 25, 2013 Category: Cancer & Oncology Authors: Larry PanSeunghee BaekPamela EdmondsMack RoachHarvey WolkovSatish ShahAlan PollackM HammondAdam Dicker Source Type: research

Magnetic resonance-guided histopathology for improved accuracy of tumor response evaluation of neoadjuvant treatment in organ-infiltrating rectal cancer
Conclusion: This response data to neoadjuvant RT/CRT in organ-infiltrating rectal cancer indicate that tumor down-staging is over-estimated by conventional evaluation. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 19, 2013 Category: Radiology Authors: Knut Håkon Hole, Stein Gunnar Larsen, Krystyna Kotanska Grøholt, Karl-Erik Giercksky, Anne Hansen Ree Tags: Original Articles Source Type: research

Magnetic resonance-guided histopathology for improved accuracy of tumor response evaluation of neoadjuvant treatment in organ-infiltrating rectal cancer.
CONCLUSION: This response data to neoadjuvant RT/CRT in organ-infiltrating rectal cancer indicate that tumor down-staging is over-estimated by conventional evaluation. PMID: 23602370 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 17, 2013 Category: Radiology Authors: Hole KH, Larsen SG, Grøholt KK, Giercksky KE, Ree AH Tags: Radiother Oncol Source Type: research

Clinicopathological features of young patients (
CONCLUSIONS: In this study, young patients with breast cancer were diagnosed at more advanced stages and had more endocrine-unresponsive tumors than non-young patients. Further prognostic analyses should be conducted in this cohort. PMID: 23588791 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 16, 2013 Category: Cancer & Oncology Authors: Kataoka A, Tokunaga E, Masuda N, Shien T, Kawabata K, Miyashita M Tags: Breast Cancer Source Type: research

Neoadjuvant treatment for unresectable rectal cancer: An interim analysis of a multicentre randomized study
Conclusions: The interim analysis revealed no major differences in acute toxicity and local efficacy between the two evaluated strategies. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - April 15, 2013 Category: Radiology Authors: Krzysztof Bujko, Anna Nasierowska-Guttmejer, Lucjan Wyrwicz, Małgorzata Malinowska, Jacek Krynski, Ewa Kosakowska, Andrzej Rutkowski, Lucyna Pietrzak, Lucyna Kepka, Jakub Radziszewski, Marta Olszyna-Serementa, Magdalena Bujko, Anna Danek, Mariusz Kryj, J Tags: Original Articles Source Type: research

Neoadjuvant treatment for unresectable rectal cancer: An interim analysis of a multicentre randomized study.
CONCLUSIONS: The interim analysis revealed no major differences in acute toxicity and local efficacy between the two evaluated strategies. PMID: 23590986 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 13, 2013 Category: Radiology Authors: Bujko K, Nasierowska-Guttmejer A, Wyrwicz L, Malinowska M, Krynski J, Kosakowska E, Rutkowski A, Pietrzak L, Kepka L, Radziszewski J, Olszyna-Serementa M, Bujko M, Danek A, Kryj M, Wydmanski J, Zegarski W, Markiewicz W, Lesniak T, Zygulski I, Porzuczek-Zu Tags: Radiother Oncol Source Type: research

Favourable long‐term outcomes with brachytherapy‐based regimens in men ≤60 years with clinically localized prostate cancer
Conclusions Brachytherapy provides patients aged ≤ 60 years with low‐ and intermediate‐risk prostate cancer with excellent outcomes and has a low risk of significant long‐term GU or GI morbidity. Erectile function is preserved in >50% of patients and the majority do not require erectile dysfunction medication. (Source: BJU International)
Source: BJU International - April 3, 2013 Category: Urology & Nephrology Authors: Marisa A. Kollmeier, Anthony Fidaleo, Xin Pei, Gil'ad Cohen, Marco Zaider, Quincy Mo, Brett Cox, Yoshiya Yamada, Michael J. Zelefsky Tags: Urological Oncology Source Type: research

Efficacy and toxicity of conventionally fractionated pelvic radiation with a hypofractionated simultaneous versus conventionally fractionated sequential boost for patients with high-risk prostate cancer.
Conclusion. Initial follow-up indicates equivalent biochemical control between regimens. Patients receiving hRT experienced fewer late rectal complications. PMID: 23544356 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 2, 2013 Category: Cancer & Oncology Authors: McDonald AM, Jacob R, Dobelbower MC, Kim RY, Fiveash JB Tags: Acta Oncol Source Type: research

Post‐esophagectomy gastric conduit cancers: treatment experiences and literature review
In this report, four patients who developed gastric conduit cancers are presented. They were treated with either surgery alone or combined with chemoradiotherapy. All four patients were still alive after at least 21 months, with three patients currently still alive (21–48 months). The literature is also reviewed, in particular addressing the incidence, possible underlying causes, prognosis and options of treatment for this specific clinical scenario. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - April 2, 2013 Category: Gastroenterology Authors: C. Ho, D. K. H. Tong, J. S. Tsang, S. Y. K. Law Tags: Case Report Source Type: research

Surgical management of the breast: breast conservation therapy and mastectomy.
Abstract The twentieth century has witnessed dramatic changes in the surgical management of breast cancer. Herein we focus on the evolution of breast conservation surgery and current surgical trends of lumpectomy, mastectomy and contralateral prophylactic mastectomy. Margin analysis, specimen localization and processing, and the benefits of magnetic resonance imaging remain controversial. Neoadjuvant chemotherapy can offer prognostic information and aid in surgical planning while radiation therapy continues to reduce the risk of local recurrence after breast conserving surgery. Despite these advances, mastectomy re...
Source: The Surgical Clinics of North America - April 1, 2013 Category: Surgery Authors: McLaughlin SA Tags: Surg Clin North Am Source Type: research

Neoadjuvant Chemoradiation for Distal Rectal Cancer: 5-Year Updated Results of a Randomized Phase 2 Study of Neoadjuvant Combined Modality Chemoradiation for Distal Rectal Cancer
Conclusions: High rates of disease-specific survival were seen in each arm. Overall survival appears affected by the development of unrelated second cancers. The high pCR rates with 5-FU and higher dose radiation in T4 cancers provide opportunity for increased R0 resections and improved survival. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 1, 2013 Category: Radiology Authors: Mohammed Mohiuddin, Rebecca Paulus, Edith Mitchell, Nader Hanna, Albert Yuen, Romaine Nichols, Salochna Yalavarthi, Cherie Hayostek, Christopher Willett Tags: Gastrointestinal Cancers Source Type: research

A Rash Decision?
Question: A 60-year-old man presented for evaluation of dysphagia secondary to a persistent esophageal stricture. He had a long history of gastroesophageal reflux and subsequently developed a T3N1 esophageal adenocarcinoma 4 years before his current presentation. He received neoadjuvant radiation/chemotherapy (5-FU/cisplatin) and underwent Ivor-Lewis esophagectomy at an outside institution. Within 12 months of surgery, he developed an anastomotic stricture refractory to endoscopic dilations. (Source: Gastroenterology)
Source: Gastroenterology - March 25, 2013 Category: Gastroenterology Authors: Ryan Law, Karthik Ravi, Jeffrey A. Alexander Tags: Clinical Challenges and Images in GI Source Type: research

Biochemical Response to Androgen Deprivation Therapy Before External Beam Radiation Therapy Predicts Long-term Prostate Cancer Survival Outcomes
Purpose: To determine whether the response to neoadjuvant androgen deprivation therapy (ADT) defined by a decline in prostate-specific antigen (PSA) to nadir values is associated with improved survival outcomes after external beam radiation therapy (EBRT) for prostate cancer.Methods and Materials: One thousand forty-five patients with localized prostate cancer were treated with definitive EBRT in conjunction with neoadjuvant and concurrent ADT. A 6-month course of ADT was used (3 months during the neoadjuvant phase and 2 to 3 months concurrently with EBRT). The median EBRT prescription dose was 81 Gy using a conformal-base...
Source: International Journal of Radiation Oncology * Biology * Physics - March 25, 2013 Category: Radiology Authors: Michael J. Zelefsky, Daniel R. Gomez, William R. Polkinghorn, Xin Pei, Marisa Kollmeier Tags: Genitourinary Cancers Source Type: research

Who Benefits From Adjuvant Radiation Therapy for Gastric Cancer? A Meta-Analysis
Purpose: Large randomized trials have demonstrated significant survival benefits with the use of adjuvant chemotherapy or chemoradiation therapy for gastric cancer. The importance of adjuvant radiation therapy (RT) remains unclear. We performed an up-to-date meta-analysis of randomized trials testing the use of RT for resectable gastric cancer.Methods and Materials: We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials for randomized trials testing adjuvant (including neoadjuvant) RT for resectable gastric cancer. Hazard ratios describing the impact of adjuvant RT on overall survival (OS) and ...
Source: International Journal of Radiation Oncology * Biology * Physics - March 21, 2013 Category: Radiology Authors: Nitin Ohri, Madhur K. Garg, Santiago Aparo, Andreas Kaubisch, Wolfgang Tome, Timothy J. Kennedy, Shalom Kalnicki, Chandan Guha Tags: Gastrointestinal Cancers Source Type: research

Radiation Therapy in Anal and Rectal Cancer
Historically, squamous cell carcinoma of the anal canal was treated with abdominoperineal resection. Nigro discovered that radiation therapy combined with 5-fluorouracil and mitomycin resulted in high rates of local control and colostomy-free and overall survival without surgical intervention. Recent advances include the integration of PET into staging, radiation treatment planning, disease monitoring, and the use of intensity-modulated radiation therapy. For rectal cancer, clinical trials have established the role for neoadjuvant therapy for T3-4 and/or node-positive tumor presentations. Chemotherapy and targeted agents a...
Source: Surgical Oncology Clinics of North America - March 21, 2013 Category: Surgery Authors: Brian G. Czito, Jeffrey Meyer Source Type: research

Neoadjuvant interferon‐based chemoradiation for borderline resectable and locally advanced pancreas cancer: a Phase II pilot study
ConclusionsInterferon‐based neoadjuvant CRT may allow for resection of locally advanced pancreatic cancer, but with significant toxicity. In the absence of surgical resection, survival remains dismal. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - March 19, 2013 Category: Gastroenterology Authors: Eric H. Jensen, Leonard Armstrong, Chung Lee, Todd M. Tuttle, Selwyn M. Vickers, Timothy Sielaff, Edward W. Greeno Tags: Original Article Source Type: research

Salvage HDR Brachytherapy for Recurrent Prostate Cancer After Previous Definitive Radiation Therapy: 5-Year Outcomes
Conclusions: Prostate HDRB is an effective salvage modality with relatively few long-term toxicities. We provide potential predictors of biochemical control for prostate salvage HDRB. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 7, 2013 Category: Radiology Authors: Chien Peter Chen, Vivian Weinberg, Katsuto Shinohara, Mack Roach, Marc Nash, Alexander Gottschalk, Albert J. Chang, I-Chow Hsu Tags: Genitourinary Cancers Source Type: research

[Primary Interdisciplinary Reconstruction of Perineal Defects to Reduce Wound Complications after Abdominoperineal Resection.]
This study was designed to retrospectively evaluate wound complications after abdominoperineal resection by comparing a group with and one without primary perineal reconstruction. Between 2005 and 2011, patients were analysed and divided into cohorts 1 and 2. Cohort 1 included n = 33 patients without primary perineal reconstruction. Cohort 2 included n = 4 patients with primary perineal reconstruction. Risk factors were identified for increased wound complications and delay of adjacent therapy.Results: Subgroup analysis revealed that 18 out of 33 patients of cohort 1 had wound complications. In five cases, prolonged wound ...
Source: Zentralblatt fur Chirurgie - March 4, 2013 Category: Surgery Authors: Mohr Z, Palmer B, Zender FJ, Willis S, Lehnhardt M, Daigeler A, Kremer T, Hirche C Tags: Zentralbl Chir Source Type: research

Chemotherapy of vulvar cancer: a review.
Abstract Squamous cell carcinoma of the vulva is a rare disease with good prognosis if diagnosed early. The standard primary therapy is surgery. Neoadjuvant radiation or chemotherapy has been used to achieve resectability of the tumor and to decrease the radicality of the surgery. Chemotherapy with platinum compounds, paclitaxel and targeted therapy (erlotinib) has shown activity. International collaborative trials are needed to identify the best therapeutic strategy for patients with squamous cell cancer of the vulva who are not candidates for primary surgery or concomitant chemoradiation. We review the various tr...
Source: Wiener Klinische Wochenschrift - March 1, 2013 Category: Journals (General) Authors: Deppe G, Mert I, Belotte J, Winer IS Tags: Wien Klin Wochenschr Source Type: research

Treatment Strategies for Esophageal Cancer
The treatment of esophageal cancer has evolved considerably in the past decade and depends largely on the extent of disease at the time of presentation. For disease confined to the esophageal mucosa, endoscopic therapy is replacing esophagectomy as the standard of care. For locoregional disease, neoadjuvant chemoradiation followed by esophagectomy is the best strategy for optimizing long-term survival. In the minority of patents who present with metastatic disease, the prognosis is poor. Palliative therapies available for these patients include chemotherapy, radiation, endoscopic therapies to ameliorate obstruction or blee...
Source: Gastroenterology Clinics of North America - March 1, 2013 Category: Gastroenterology Authors: Dylan R. Nieman, Jeffrey H. Peters Source Type: research

Salvage high-intensity focused ultrasound ablation for prostate cancer local recurrence after external-beam radiation therapy: Prognostic value of prostate MRI
Aim: To assess the prognostic value of magnetic resonance imaging (MRI) before salvage high-intensity focused ultrasound (HIFU) for locally recurrent prostate cancer after external-beam radiotherapy (EBRT).Materials and methods: Forty-six patients who underwent prostate MRI before salvage HIFU for locally recurrent prostate cancer after EBRT were retrospectively studied. HIFU failure was defined as a prostate-specific antigen (PSA) value >nadir + 2 ng/ml (Phoenix criteria) or positive follow-up biopsy or initiation of any other salvage therapy. The following prognostic parameters were assessed: neoadjuvant hormone thera...
Source: Clinical Radiology - March 1, 2013 Category: Radiology Authors: O. Rouvière, L. Sbihi, A. Gelet, J.-Y. Chapelon Tags: Original Papers Source Type: research

Preoperative Cetuximab, Irinotecan, Cisplatin, and Radiation Therapy for Patients with Locally Advanced Esophageal Cancer.
Conclusions. This schedule of cetuximab in combination with irinotecan, cisplatin, and radiation therapy was toxic and did not achieve a sufficient pCR rate in patients with localized esophageal adenocarcinoma to undergo further evaluation. PMID: 23429739 [PubMed - as supplied by publisher] (Source: The Oncologist)
Source: The Oncologist - February 21, 2013 Category: Cancer & Oncology Authors: Lee MS, Mamon HJ, Hong TS, Choi NC, Fidias PM, Kwak EL, Meyerhardt JA, Ryan DP, Bueno R, Donahue DM, Jaklitsch MT, Lanuti M, Rattner DW, Fuchs CS, Enzinger PC Tags: Oncologist Source Type: research

Osteosarcomas of the mandible: multidisciplinary management of a rare tumor of the young adult a cooperative study of the GSF-GETO, Rare Cancer Network, GETTEC/REFCOR and SFCE
Conclusion This homogeneous series is the largest to date and emphasizes the major impact of clear margins and multidisciplinary management. Neoadjuvant chemotherapy improves disease-free survival and should be recommended for both high and intermediate grade MOS. (Source: Annals of Oncology)
Source: Annals of Oncology - February 16, 2013 Category: Cancer & Oncology Authors: Thariat, J., Schouman, T., Brouchet, A., Sarini, J., Miller, R. C., Reychler, H., Ray-Coquard, I., Italiano, A., Verite, C., Sohawon, S., Bompas, E., Dassonville, O., Salas, S., Aldabbagh, K., Maingon, P., de La MotteRouge, T., Kurtz, J. E., Usseglio, J., Tags: sarcomas Source Type: research

CT Texture Analysis Of Tumors May Be A Valuable Biomarker In Localized Esophageal Cancer
CT texture analysis of primary tumors may be a potential imaging biomarker in localized esophageal cancer following neoadjuvant chemotherapy, according to research presented at the 2013 Cancer Imaging and Radiation Therapy Symposium. This Symposium is sponsored by the American Society for Radiation Oncology (ASTRO) and the Radiological Society of North American (RSNA)... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 12, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Tumoral Texture Features May Be A Valuable Biomarker In Localized Esophageal Cancer
CT texture analysis of primary tumors may be a potential imaging biomarker in localized esophageal cancer following neoadjuvant chemotherapy, according to research presented at the 2013 Cancer Imaging and Radiation Therapy Symposium. This Symposium is sponsored by the American Society for Radiation Oncology (ASTRO) and the Radiological Society of North American (RSNA)... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 12, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

CT texture analysis of tumors may be a valuable biomarker in localized esophageal cancer
(American Society for Radiation Oncology) CT texture analysis of primary tumors may be a potential imaging biomarker in localized esophageal cancer following neoadjuvant chemotherapy, according to research being presented at the 2013 Cancer Imaging and Radiation Therapy Symposium. This Symposium is sponsored by the American Society for Radiation Oncology and the Radiological Society of North America. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 8, 2013 Category: Global & Universal Source Type: news

Surgical Management of the Breast: Breast Conservation Therapy and Mastectomy
The twentieth century has witnessed dramatic changes in the surgical management of breast cancer. Herein we focus on the evolution of breast conservation surgery and current surgical trends of lumpectomy, mastectomy and contralateral prophylactic mastectomy. Margin analysis, specimen localization and processing, and the benefits of magnetic resonance imaging remain controversial. Neoadjuvant chemotherapy can offer prognostic information and aid in surgical planning while radiation therapy continues to reduce the risk of local recurrence after breast conserving surgery. Despite these advances, mastectomy remains a popular c...
Source: Surgical Clinics of North America - February 4, 2013 Category: Surgery Authors: Sarah A. McLaughlin Source Type: research

Clinical Relevance of PET/CT positive inguinal nodes in rectal cancer after neoadjuvant chemoradiation
ConclusionUptake of inguinal nodes at PET/CT may be present in up to 17% of patients with distal rectal cancer, particularly with ultra‐low tumours. Nearly half of these nodes no longer show uptake after CRT despite the groin area not being included in the radiation field. Persistence of inguinal node uptake after 12 weeks of CRT completion may be a marker for worse oncological outcome.© 2013 The Authors. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland (Source: Colorectal Disease)
Source: Colorectal Disease - February 1, 2013 Category: Gastroenterology Authors: Rodrigo O. Perez, Angelita Habr‐Gama, Guilherme P. São Julião, Igor Proscurshim, Carla Rachel Ono, Patricio Lynn, Patricia Bailão Aguilar, Sergio Carlos Nahas, Joaquim Gama‐Rodrigues, Carlos Alberto Buchpiguel Tags: Original Article Source Type: research

Pathological response to neoadjuvant chemotherapy for muscle‐invasive micropapillary bladder cancer
Conclusions Almost half of the patients responded completely to neoadjuvant chemotherapy with a pT0 rate of 45%; therefore, patients with the micropapillary variant of urothelial carcinoma should not be excluded from consideration for neoadjuvant chemotherapy. (Source: BJU International)
Source: BJU International - February 1, 2013 Category: Urology & Nephrology Authors: Joshua J. Meeks, Jennifer M. Taylor, Kazuhito Matsushita, Harry W. Herr, S. Machele Donat, Bernard H. Bochner, Guido Dalbagni Tags: Urological Oncology Source Type: research

Novel aspects of preoperative chemo(radiation)therapy improving anti‐tumor immunity in pancreatic cancer
Conclusion, preoperative chemo(radiation)therapy in pancreatic adenocarcinoma is useful for reducing regulatory T cell levels in combination with it's direct cytotoxic effects. (Source: Cancer Science)
Source: Cancer Science - January 31, 2013 Category: Cancer & Oncology Authors: Takahiro Tsuchikawa, Satoshi Hirano, Eiichi Tanaka, Joe Matsumoto, Kentaro Kato, Toru Nakamura, Yuma Ebihara, Toshiaki Shichinohe Tags: Original Article Source Type: research

Utilization of surgery in trimodality‐eligible patients with locally advanced esophageal adenocarcinoma in a nonprotocol setting
Summary Trimodality therapy with neoadjuvant chemoradiation followed by surgery significantly improves the survival of locally advanced (clinical stage IIA–III) esophageal cancer patients compared to treatment with surgery alone. This has resulted in an increased use of neoadjuvant therapy in recent years, yet little is known regarding how this increase has impacted the utilization of surgery in the treatment of locally advanced disease. Although previous reports of experimental protocols suggest that 90–95% of patients complete trimodality therapy including a surgical resection, trimodality therapy completion among ad...
Source: Diseases of the Esophagus - January 25, 2013 Category: Gastroenterology Authors: C. C. Murphy, W. L. Hofstetter, A. M. Correa, J. A. Ajani, R. U. Komaki, S. G. Swisher Tags: Original article Source Type: research

Neuroendocrine carcinoma of the uterine cervix: The role of multimodality therapy in early-stage disease.
CONCLUSIONS: Cervical NEC is an aggressive disease associated with a high mortality rate. Patients with advanced-stage disease have a poor prognosis regardless of therapy. However, multimodality with consideration of triple-modality therapy in early-stage disease has the potential for complete response and long-term survival, supporting the goal of curative intent in these patients. PMID: 23357610 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - January 25, 2013 Category: Cancer & Oncology Authors: McCann GA, Boutsicaris CE, Preston MM, Backes FJ, Eisenhauer EL, Fowler JM, Cohn DE, Copeland LJ, Salani R, O'Malley DM Tags: Gynecol Oncol Source Type: research