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Recurrence after neoadjuvant chemoradiation and surgery for esophageal cancer: Does the pattern of recurrence differ for patients with complete response and those with partial or no response?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Most esophageal cancer recurrences after neoadjuvant therapy and surgery are distant, and survival time after recurrence is short regardless of pathologic response. Fewer patients achieving complete response had recurrences, and distant recurrences in these patients manifest later than in patients showing partial response and those showing no response. Only pathologic response is significantly associated with disease recurrence, suggesting that tumor biology and chemosensitivity are critical in long-term patient outcome. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - November 20, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Robert A. Meguid, Craig M. Hooker, Joshua T. Taylor, Laurence R. Kleinberg, Stephen M. Cattaneo, Marc S. Sussman, Stephen C. Yang, Richard F. Heitmiller, Arlene A. Forastiere, Malcolm V. Brock Tags: General Thoracic Surgery Source Type: journals

Pneumonectomy After Neoadjuvant Chemotherapy and Radiation for Advanced-Stage Lung CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Using a multidisciplinary team approach at a tertiary care center, pneumonectomy can be performed successfully after neoadjuvant chemotherapy and radiation for advanced-stage lung cancer. Vascularized flap for bronchial stump coverage may be important in this regard. Content Type Journal ArticleCategory Thoracic OncologyDOI 10.1245/s10434-009-0810-0Authors Thomas Ng, The Warren Alpert Medical School of Brown University Brown University Oncology Group Providence RI USAAriel E. Birnbaum, The Warren Alpert Medical School of Brown University Brown University Oncology Group Providence RI USAJac...
Source: Annals of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Revisiting the prognostic value of preoperative 18F-fluoro-2-deoxyglucose (18F-FDG) positron emission tomography (PET) in early-stage (I & II) non-small cell lung cancers (NSCLC)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Each doubling of SUVmax as determined by preoperative PET is associated with a 1.28-fold increase in hazard of death in early-stage (I & II) NSCLC. Preoperative SUVmax is not an independent predictor of overall survival. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-009-1291-xAuthors Mohit Agarwal, Oakland University William Beaumont School of Medicine Hospital Department of Internal Medicine 3601 W 13 Mile Rd Royal Oak MI 48073-6769 USAGovinda Brahmanday, Oakland University William Beaumont School of Medicine Hospital Department of Internal Medicine 3601 W 13 Mile ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - November 13, 2009 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

Antagonistic interaction between bicalutamideTM (Casodex®) and radiation in androgen-positive prostate cancer LNCaP cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BicalutamideTM (Casodex®) reportedly improves high-risk prostate cancer survival as an adjuvant treatment following radiotherapy. However, biological data for the interaction between bicalutamide and ionizing radiation in concomitant association are lacking.To explore this issue, androgen-dependent (LNCaP) and -independent (DU145) human prostate cancer cells were exposed for 48 hr to 20, 40, or 80 µM bicalutamide introduced before (neoadjuvant), during (concomitant), or following (adjuvant) radiation. Growth inhibition and cytotoxicity, cell cycle distribution and expression of the prostate serum antigen (PSA) and androg...
Source: The Prostate - November 9, 2009 Category: Urology & Nephrology Authors: Laurent Quéro, Nicole Giocanti, Christophe Hennequin, Vincent Favaudon Source Type: journals

Modified neoadjuvant short-course radiation therapy in uT3 rectal carcinoma: low local recurrence rate with unchanged overall survival and frequent morbidityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Compared to the literature-modified 8 × 3 Gy neoadjuvant SCRT and surgery in uT3, rectal carcinoma was associated with low local recurrence but frequent peri-operative complications. The decisive prognostic factor, distant metastasis, was unaffected. Difficulties included overestimation of tumour invasion depth by endosonography. Possible clinical consequences of the results are discussed. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0823-yAuthors Rainer Kube, An-Institut für Qualitätssicherung in der operativen Medizin (gGmbH) an der Otto-von-Gu...
Source: International Journal of Colorectal Disease - October 30, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals

Thymidine phosphorylase to dihydropyrimidine dehydrogenase ratio as a predictive factor of response to preoperative chemoradiation with capecitabine in patients with advanced rectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To identify if thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and ratio TP/DPD levels in tumor tissues are potential predictive factors for response to combined preoperative chemoradiation with capecitabine, in patients with locally advanced rectal cancer (LARC).Between 2004 and 2006, 28 patients with LARC (cT2-T4, N0-N2) were treated with neoadjuvant chemoradiation. Total radiation dose was 50.4 Gy and daily dose was 1.8 Gy in 5.5 weeks. Capecitabine was administrated 1,650 mg/m2/day, 7 days/week. Preoperative staging was based on combined computer tomography and endorectal ultrasound. Tissue samples...
Source: Journal of Surgical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: C.S. Boskos, C. Liacos, D. Korkolis, K. Aygerinos, I. Lamproglou, E. Terpos, E. Stoupa, G. Baltatzis, K. Beroukas, P. Papasavvas, M.A. Dimopoulos, A. Bamias Source Type: journals

Cardiac safety of trastuzumab as adjuvant treatment for Japanese patients with early breast cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The incidence of cardiac events caused by trastuzumab treatment was low in our analysis. Adjuvant trastuzumab treatment for up to at least 1 year should be safe for Japanese breast cancer patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-009-0898-zAuthors Mikiya Ishihara, National Cancer Center Hospital East Division of Oncology/Hematology 6-5-1 Kashiwanoha, Kashiwa Chiba 277-8577 JapanHirofumi Mukai, National Cancer Center Hospital East Division of Oncology/Hematology 6-5-1 Kashiwanoha, Kashiwa Chiba 277-8577 JapanShunji Nagai, National Cancer Center Hospital...
Source: International Journal of Clinical Oncology - October 24, 2009 Category: Cancer & Oncology Tags: International Journal of Clinical Oncology Source Type: journals

A Systematic Review of Resectability and Survival After Concurrent Chemoradiation in Primarily Unresectable Pancreatic CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The finding of a high proportion of R0 resection among all resections performed confirms the activity of neoadjuvant radiochemotherapy and should not be neglected. Based on these data, patients with unresectable pancreatic cancer without disease progression after chemoradiotherapy should be considered for radical surgery. Content Type Journal ArticleCategory Radiation OncologyDOI 10.1245/s10434-009-0762-4Authors Alessio G. Morganti, Catholic University Department of Radiation Oncology, “John Paul II” Center for High Technology Research and Education in Biomedical Sciences Campobasso It...
Source: Annals of Surgical Oncology - October 24, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Short-term outcomes of laparoscopic total mesorectal excision following neoadjuvant chemoradiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In our experience, laparoscopic TME for mid and lower rectal cancer is feasible and safe. Patients benefit from the short-term advantages of laparoscopy, including shorter length of hospital stay, time to tolerating a regular diet, and time to first bowel movement or stoma function. Although there were no short-term differences in oncologic parameters, the long-term oncologic outcome requires further investigation. Content Type Journal ArticleDOI 10.1007/s00464-009-0702-1Authors P. Denoya, Cleveland Clinic Blvd Department of Colorectal Surgery 2950 Weston Fl 33331 USAH. Wang, Cleveland Cl...
Source: Surgical Endoscopy - October 22, 2009 Category: Surgery Tags: Surgical Endoscopy Source Type: journals

Notes from the 8th International SymposiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patient advocates generously volunteered their time to take notes at the recent 8th International Kidney Cancer Symposium, in Chicago. These notes are intended to capture the essence of this important medical meeting and convey it in a way that is useful to patients, survivors, and their families. The first installment sumarizes the Saturday morning session. Integration of Surgical and Systemic Therapy in Metastatic RCC This session was opened by Dr. Bradley Leibovich who presented two cases on which the audience voted on methods to integrate surgery with systemic treatment int...
Source: Kidney Cancer Association - October 14, 2009 Category: Cancer & Oncology Source Type: organizations

Mesothelioma: Path to Multimodality TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Multimodality treatment of malignant pleural mesothelioma (MPM) with surgery, radiation therapy, and adjuvant or neoadjuvant chemotherapy is the sole path to extended survival for select patients with favorable prognostic factors. No single-modality approach has produced equivalent results. Much effort has been expended since first recognition of this insidious pleural cancer to elucidate the underlying cause and optimal treatment strategy. Despite recent breakthroughs, the principal barrier to achieving a cure rests with the propensity for disease recurrence in the ipsilateral hemithorax. Despite these limitations, howeve...
Source: Seminars in Thoracic and Cardiovascular Surgery - October 12, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Stacey Su Tags: Multimodality Management of Malignant Pleural Mesothelioma - David J. Sugarbaker, MD, Guest Editor Source Type: journals

Locally advanced rectal cancer: added value of diffusion-weighted MR imaging in the evaluation of tumor response to neoadjuvant chemo- and radiation therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Adding DW MR imaging to conventional MR imaging yields better diagnostic accuracy than use of conventional MR imaging alone in the evaluation of CR to neoadjuvant CRT in patients with locally advanced rectal cancer. PMID: 19789256 [PubMed - in process] (Source: Radiology)
Source: Radiology - September 30, 2009 Category: Radiology Authors: Kim SH, Lee JM, Hong SH, Kim GH, Lee JY, Han JK, Choi BI Tags: Radiology Source Type: journals

Improved patient and regimen selection in locally advanced rectal cancer: who, how, and what next?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Before the advent of neoadjuvant chemoradiation therapy (NCRT) for locally advanced rectal cancer, local failure represented half of treatment failures. The German Rectal Cancer Study Group trial demonstrated that NCRT along with total mesorectal excision can improve local control and the rate of sphincter-preserving surgery. Thus, the National Comprehensive Cancer Network now recommends NCRT as the standard of care for stage III and IV rectal cancer. Recent trials and analysis have questioned accepted wisdom regarding patient selection for NCRT and methods of administration. EORTC 22921 demonstrated that the addition ...
Source: Clinical Colorectal Cancer - September 30, 2009 Category: Cancer & Oncology Authors: Weiss J, Moghanaki D, Plastaras JP, Haller DG Tags: Clin Colorectal Cancer Source Type: journals

Downsizing to resectabilty of a large solid and cystic papillary tumor of the pancreas by single-agent chemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 14-year-old female with SCPT who was successfully downsized with gemcitabine before definitive surgical resection. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - September 30, 2009 Category: Surgery Authors: Julie Kanter, David B. Wilson, Steven Strasberg Tags: Journal of Pediatric Surgery Electronic Pages (Available only online at www.jpedsurg.org) Source Type: journals

Effects of preoperative chemoradiotherapy on anal sphincter functions and quality of life in rectal cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Both total mesorectal excision and preoperative chemoradiotherapy may adversely affect the anorectal function. Careful selection of the patients who will benefit from neoadjuvant therapy and identifying the patients with a high risk of developing functional problems may help to improve functional outcomes for the treatment of rectal cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-009-0807-yAuthors Aras Emre Canda, Dokuz Eylul University School of Medicine Department of Surgery 35340 Inciralti Izmir TurkeyCem Terzi, Dokuz Eylul University School of Medicine D...
Source: International Journal of Colorectal Disease - September 28, 2009 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: journals

Toxicity and outcomes after chemoradiation for esophageal cancer in patients age 75 or olderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, elderly patients experienced substantial morbidity from chemoradiation, and long-term survival was low. Future efforts to improve treatment tolerability in the elderly are needed. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - September 25, 2009 Category: Gastroenterology Authors: R. H. Mak, H. J. Mamon, D. P. Ryan, D. T. Miyamoto, M. Ancukiewicz, W. K. Kobayashi, C. G. Willett, N. C. Choi, L. S. Blaszkowsky, T. S. Hong Source Type: journals

Optical tomography of breast cancer—monitoring response to primary medical therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Diffuse optical imaging and spectroscopy use near-infrared light to derive physiological parameters such as total hemoglobin concentration and tissue oxygen saturation. Numerous clinical studies have been carried out, either using stand-alone optical methods or in combination with alternative imaging techniques. Studies have demonstrated that diffuse optical imaging and spectroscopy are able to distinguish malignant lesions from benign tissues. Breast cancer is characterized by an increase in total hemoglobin and a decrease in tissue oxygen saturation. Benign lesions such as cysts and fibroadenomas ...
Source: Targeted Oncology - September 24, 2009 Category: Cancer & Oncology Tags: Targeted Oncology Source Type: journals

Who Benefits from Neoadjuvant or Adjuvant Hormone Therapy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Neoadjuvant or adjuvant HT to RT may improve treatment outcomes, including OS in appropriately selected patients with PCa.Take Home Message: Neoadjuvant or adjuvant hormone therapy to radiation therapy may improve treatment outcomes in carefully selected patients with prostate cancer. (Source: European Urology Supplements)
Source: European Urology Supplements - September 23, 2009 Category: Urology & Nephrology Authors: Alberto Bossi Source Type: journals

Bladder CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Opinion statement Bladder cancer is a complex disease of older patients with coexisting medical problems requiring multimodal therapy. For patients with localized bladder cancer, standard management for superficial disease includes transurethral resection with or without intravesical therapy, while muscle-invasive cancer is managed with neoadjuvant cisplatin-based chemotherapy followed by radical cystectomy. Comorbid conditions prevent many older patients from receiving cisplatin-based chemotherapy and/or undergoing surgery. Tri-modality bladder preservation approaches including a complete transurethral rese...
Source: Current Treatment Options in Oncology - September 22, 2009 Category: Cancer & Oncology Tags: Current Treatment Options in Oncology Source Type: journals

Age dictates risk when neoadjuvant hormone therapy is added to prostate brachytherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The risks associated with neoadjuvant hormonal therapy may outweigh the benefits of its use in conjunction with brachytherapy in some older men with prostate cancer, according to research from the radiation oncology program at Boston’s Harvard Medical School. (Source: Cancer Network)
Source: Cancer Network - September 22, 2009 Category: Cancer & Oncology Source Type: info

Helical Tomotherapy Significantly Reduces Dose to Normal Tissues When Compared to 3D-CRT for Locally Advanced Rectal Cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we dosimetrically compare helical tomotherapy to 3D-CRT for stage T3 rectal cancer. The helical tomotherapy plans were optimized in the TomoPlan system to achieve an equivalent uniform dose of 45 Gy for 10 patients with T3N0M0 disease that was at least 5cm from the anal verge. The GTV included the rectal thickening and mass evident on colonoscopy and CT scan as well as with the help of a colorectal surgeon. The CTV included the internal iliac, obturator, and pre-sacral lymphatic chains. The OAR that were outlined included the small bowel, pelvic bone marrow, femoral heads, and bladder. Anatom-e system was use...
Source: Technology in Cancer Research and Treatment - September 18, 2009 Category: Cancer & Oncology Authors: Jhaveri PM, Teh BS, Paulino AC, Smiedala MJ, Fahy B, Grant W, McGary J, Butler EB Tags: Technol Cancer Res Treat Source Type: journals

Downstaging of Pancreatic Carcinoma after Neoadjuvant ChemoradiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The current results support randomized testing of neoadjuvant chemoradiation to prove survival prolongation. Compared to the literature this approach seems to reduce the number of positive nodes. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00066-009-1977-9Authors Dominik Tinkl, University of Erlangen-Nuremberg Department of Radiation Oncology, Friedrich Alexander Erlangen GermanyGerhard G. Grabenbauer, University of Erlangen-Nuremberg Department of Radiation Oncology, Friedrich Alexander Erlangen GermanyHenriette Golcher, University of Erlangen-Nuremberg Department o...
Source: Strahlentherapie und Onkologie - September 15, 2009 Category: Cancer & Oncology Tags: Strahlentherapie und Onkologie Source Type: journals

Is postoperative early enteral nutrition with regular or disease-specific enteral formula really beneficial in patients undergoing esophagectomy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Although recent studies have shown that early enteral nutrition (EEN) has certain advantages over parenteral nutrition for preventing postoperative complications, few previous studies have examined the effects of enteral nutrition in patients undergoing esophagectomy. Here we review the effects of EEN with regular polymeric or other disease-specific enteral formulas in patients undergoing esophagectomy. Previously reported data suggest that nutritional management with early enteral feeding may be beneficial and that an appropriate selection of specific enteral formula enriched with disease-specific ...
Source: Esophagus - September 15, 2009 Category: Gastroenterology Tags: Esophagus Source Type: journals

The potential of optical proteomic technologies to individualize prognosis and guide rational treatment for cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Genomics and proteomics will improve outcome prediction in cancer and have great potential to help in the discovery of unknown mechanisms of metastasis, ripe for therapeutic exploitation. Current methods of prognosis estimation rely on clinical data, anatomical staging and histopathological features. It is hoped that translational genomic and proteomic research will discriminate more accurately than is possible at present between patients with a good prognosis and those who carry a high risk of recurrence. Rational treatments, targeted to the specific molecular pathways of an individual’s high-ris...
Source: Targeted Oncology - September 15, 2009 Category: Cancer & Oncology Tags: Targeted Oncology Source Type: journals

Advances in diagnosis, treatment and palliation of cholangiocarcinoma: 1990-2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several advances in diagnosis, treatment and palliation of cholangiocarcinoma (CC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. CC is a relatively rare tumor and the main risk factors are: chronic inflammation, genetic predisposition and congenital abnormalities of the biliary tree. While the incidence of intra-hepatic CC is increasing, the incidence of extra-hepatic CC is trending down. The only curative treatment for CC is surgical resection with negative margins. Liver transplantation has been proposed only for selected patients with hilar CC that cannot b...
Source: World Journal of Gastroenterology - September 13, 2009 Category: Gastroenterology Authors: Aljiffry M, Walsh MJ, Molinari M Tags: World J Gastroenterol Source Type: journals

Surgical resection after TNFerade therapy for locally advanced pancreatic cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Neoadjuvant TNFerade based chemoradiation therapy may be a useful adjunct to treatment of locally advanced pancreatic cancer. PMID: 19734632 [PubMed - in process] (Source: JOP)
Source: JOP - September 9, 2009 Category: Gastroenterology Authors: Chadha MK, Litwin A, Levea C, Iyer R, Yang G, Javle M, Gibbs JF Tags: JOP Source Type: journals

A Case of Capecitabine-induced Hyperpigmentation and Radiation Recall PhenomenonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an unusual case of skin hyperpigmentation and radiation recall phenomenon after the administration of capecitabine. A 44-year-old patient with a previous history of right mastectomy for an invasive ductal carcinoma underwent neoadjuvant chemotherapy (six cycles of adriamycin and cyclophosphamide), left mastectomy, chest wall and supraclavicular fossa radiotherapy for a T3, oestrogen receptor-positive second primary invasive lobular carcinoma in the left breast. She developed pleural, liver and bone metastasis while still on adjuvant anastrazole about 28 months from the completion of her left chest wall radiother...
Source: Clinical Oncology - September 7, 2009 Category: Radiology Authors: N. Ghosal, V. Misra Tags: Letters Source Type: journals

Radiation Techniques and Toxicities for Locally Advanced Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the technical aspects of radiation therapy for locally advanced breast cancer with emphasis on 3-dimensional radiotherapy techniques and discusses potential toxicities and how to reduce them. (Source: Seminars in Radiation Oncology)
Source: Seminars in Radiation Oncology - September 3, 2009 Category: Cancer & Oncology Authors: Meena S. Moran, Bruce G. Haffty Source Type: journals

Inflammatory Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inflammatory breast cancer (IBC) represents the most virulent form of breast cancer, characterized by involvement of the skin and rapid progression of the disease. Management involves careful coordination of all multidisciplinary modalities, including imaging, systemic chemotherapy, surgery, and radiation therapy. The use of neoadjuvant chemotherapy has contributed significantly to improvement in overall survival since the first descriptions of this entity and has made the role of locoregional therapy, including surgery and radiation critical to continued improvements in this disease. In this article, we examine the unique...
Source: Seminars in Radiation Oncology - September 3, 2009 Category: Cancer & Oncology Authors: Wendy A. Woodward, Massimo Cristofanilli Source Type: journals

Workup and Staging of Locally Advanced Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews current approaches for workup and staging in patients with locally advanced breast cancer (LABC). Careful clinical examination and detailed imaging are discussed to accurately classify the extent of local, regional, and distant disease. Most patients with LABC receive neoadjuvant chemotherapy as initial treatment, and, in such patients, it is critical to accurately delineate the initial extent of disease because the initial clinical stage affects subsequent local-regional treatment decisions. Emphasis is placed on sonography, which is used extensively at the University of Texas M. D. Anderson Cancer Ce...
Source: Seminars in Radiation Oncology - September 3, 2009 Category: Cancer & Oncology Authors: Gary J. Whitman, Eric A. Strom Source Type: journals

Neoadjuvant Chemotherapy for Locally Advanced Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Preoperative systemic therapy is the standard of care in locally advanced breast cancer. In this setting, the intent of preoperative systemic therapy is to expand surgical options and to improve survival. Locally advanced and inflammatory breast cancer have different biological features, but they share the use of preoperative (primary, neoadjuvant) systemic therapy as the initial treatment of choice. The management of these patients necessitates involvement of a multidisciplinary team from the onset and during therapy. The eradication of invasive cancer from the breast and axillary lymph nodes, pathologic complete response...
Source: Seminars in Radiation Oncology - September 3, 2009 Category: Cancer & Oncology Authors: Jennifer Specht, Julie R. Gralow Source Type: journals

Breast Conservation Therapy for Patients With Locally Advanced Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neoadjuvant chemotherapy achieves high response rates in patients with breast cancer and has been used to reduce tumor size and allow for breast conservation in individuals who initially required mastectomy. The goals of this approach are to achieve optimal locoregional control together with acceptable cosmesis. In the setting of locally advanced disease, breast preservation appears to be feasible for appropriately selected patients whose tumors show adequate downstaging in response to induction chemotherapy. Nevertheless, further prospective randomized trials are warranted to better evaluate the results of this approach a...
Source: Seminars in Radiation Oncology - September 3, 2009 Category: Cancer & Oncology Authors: Mohamed A. Alm El-Din, Alphonse G. Taghian Source Type: journals

[Risk factors related to lymph node metastases after neoadjuvant therapy for locally advanced rectal cancer.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Pathologic T stage is the most reliable predictor of lymph node stage in rectal cancer patients received preoperative RT or CRT. Oxaliplatin-containing regimens could significantly reduce the risks of lymph node metastases and potentially improve the prognosis. PMID: 19728908 [PubMed - in process] (Source: Ai Zheng)
Source: Ai Zheng - August 31, 2009 Category: Cancer & Oncology Authors: Zeng ZF, Ding PR, Pan ZZ, Lin JZ, Li LR, Lu ZH, Wu XJ, Kong LH, Zhou ZG, Wan DS Tags: Ai Zheng Source Type: journals

Incidence of anastomotic leak in patients undergoing elective colon resection without mechanical bowel preparation: our updated experience and two-year review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a prospective study evaluating the anastomotic leak rate in patients undergoing elective colorectal surgery without preoperative mechanical bowel preparation. One hundred fifty-three patients undergoing elective colon resection from July 2006 to June 2008 were enrolled into this Institutional Review Board-approved study. All patients were operated on by a single surgeon at a single institution. No patients received mechanical bowel preparation. Of the 153 patients enrolled, 51.6 per cent had a colorectostomy, 32 per cent had an ileocolostomy, 10.4 per cent had a colocolostomy, 5.2 per cent had an ileoanal anastom...
Source: The American Surgeon - August 31, 2009 Category: Surgery Authors: Harris LJ, Moudgill N, Hager E, Abdollahi H, Goldstein S Tags: Am Surg Source Type: journals

Neoadjuvant chemotherapy for resectable non-small-cell lung cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lung cancer generally has an unfavorable prognosis. For those with resectable disease, the use of neoadjuvant chemotherapy has the potential to reduce tumor volume, address micrometastatic disease early, and improve outcomes. Randomized trials comparing neoadjuvant platinum-based regimens with surgery alone were able to demonstrate the feasibility and safety of this modality. These trials supported evidence found in phase II trials that utilized third-generation chemotherapies. Still, limitations to these studies exist, such as the inclusion of various disease stages in one study, inter- and intratrial variability of t...
Source: Oncology (Williston Park, N.Y.) - August 31, 2009 Category: Cancer & Oncology Authors: Gray J, Sommers E, Alvelo-Rivera M, Robinson L, Bepler G Tags: Oncology (Williston Park) Source Type: journals

The Incidence of Perioperative Anastomotic Complications After Sleeve Lobectomy Is Not Increased After Neoadjuvant Chemoradiotherapy [ORIGINAL ARTICLES: GENERAL THORACIC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Anastomosis-related complications were not increased among the patients receiving neoadjuvant therapy compared with those who did not. In addition, local recurrence was also similar between the two groups. Furthermore, the survival of the two groups was not statistically different. Sleeve lobectomy after chemoradiotherapy for advanced non–small cell lung cancer can be performed with acceptable morbidity and mortality. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - August 30, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Milman, S., Kim, A. W., Warren, W. H., Liptay, M. J., Miller, C., Basu, S., Faber, L. P. Tags: Lung - cancer ORIGINAL ARTICLES: GENERAL THORACIC Source Type: journals

Role of surgery in a multidisciplinary approach to Superior Sulcus Tumors (SST): morbidity and prognostic factors for long-term success after resection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Surgery has a role in the multidisciplinary approach, especially when we consider long-term survival. A multidisciplinary approach using neoadjuvant chemo and radiotherapy has a high rate of complete pathological response. It is also associated with a high incidence of postoperative distress syndrome. The 5-year survival is acceptable. PMID: 19707978 [PubMed - in process] (Source: The Thoracic and Cardiovascular Surgeon)
Source: The Thoracic and Cardiovascular Surgeon - August 29, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Torre W, Garcia-Franco C, Tamura A, Gurpide A, Lopez-Picazo J, Aristu J, Moreno M, Pardo J Tags: Thorac Cardiovasc Surg Source Type: journals

Role of Surgery in a Multidisciplinary Approach to Superior Sulcus Tumors (SST): Morbidity and Prognostic Factors for Long-Term Success after ResectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thorac cardiovasc Surg 2009; 57: 353-357DOI: 10.1055/s-0029-1185786Abstract Optimal management of SST is still controversial several years after the proposal of a multidisciplinary approach including neoadjuvant chemotherapy and external radiation. Our objective is to report our experience of this multidisciplinary approach from the surgical point of view. From January 1997 to January 2008, 24 patients were treated surgically (18 with induction chemotherapy and 15 with radiotherapy). The surgical approach was thoracic (14 cases, 1 with a spinal approach) or cervical (10 patients, 2 thoracotomies). Pulmonary surgery perform...
Source: The Thoracic and Cardiovascular Surgeon - August 26, 2009 Category: Cardiovascular & Thoracic Surgery Tags: Original Thoracic Source Type: journals

The incidence of perioperative anastomotic complications after sleeve lobectomy is not increased after neoadjuvant chemoradiotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Anastomosis-related complications were not increased among the patients receiving neoadjuvant therapy compared with those who did not. In addition, local recurrence was also similar between the two groups. Furthermore, the survival of the two groups was not statistically different. Sleeve lobectomy after chemoradiotherapy for advanced non-small cell lung cancer can be performed with acceptable morbidity and mortality. PMID: 19699925 [PubMed - in process] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - August 25, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Milman S, Kim AW, Warren WH, Liptay MJ, Miller C, Basu S, Faber LP Tags: Ann Thorac Surg Source Type: journals

ORIGINAL CONTRIBUTION: Hormonal Therapy Use for Prostate Cancer and Mortality in Men With Coronary Artery Disease-Induced Congestive Heart Failure or Myocardial InfarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Neoadjuvant HT use is significantly associated with an increased risk of all-cause mortality among men with a history of CAD-induced CHF or MI but not among men with no comorbidity or a single CAD risk factor. (Source: JAMA)
Source: JAMA - August 24, 2009 Category: Journals (General) Authors: Nanda, A., Chen, M.-H., Braccioforte, M. H., Moran, B. J., D'Amico, A. V. Tags: Men's Health, Prostate Disease, Oncology, Prostate Cancer, Cardiovascular System, Cardiovascular Disease/ Myocardial Infarction, Drug Therapy, Adverse Effects, Congestive Heart Failure/ Cardiomyopathy Original Contribution Source Type: journals

A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on the quality of life (QOL) outcomes for this trial.From December 1997 through February 2003, 244 men with newly diagnosed localized prostate cancer were randomly assigned to cryoablation or EBRT (median dose 68 Gy). All patients received neoadjuvant antiandrogen therapy. Patients completed the EORTC QLQ C30 and the Prostate Cancer Index (PCI) before treatment and at 1.5, 3, 6, 12, 18, 24, and 36 months post-treatment.Regardless of treatment arm, participants reported high levels of QOL with few exceptions. cryoablation was associated with more acute urinary dysfunction (mean PCI urinary function cryoablation = ...
Source: Cancer - August 17, 2009 Category: Cancer & Oncology Authors: John W. Robinson, Bryan J. Donnelly, Jodi E. Siever, John C. Saliken, Scott D. Ernst, John C. Rewcastle, Kiril Trpkov, Harold Lau, Cheryl Scott, Bejoy Thomas Source Type: journals

Why are pretreatment prostate-specific antigen levels and biochemical recurrence poor predictors of prostate cancer survival?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The value of pretreatment (initial) prostate-specific antigen (iPSA) and biochemical recurrence (BR) as prognostic factors for survival remains unclear. The authors sought to determine why using randomized trial data with 7-year minimum follow-up.In the Trans-Tasman Radiation Oncology Group 96.01 trial, 802 men with T2b, T2c, T3, or T4 N0 prostate cancer (PC) were randomized to radiotherapy alone or with 3 or 6 months neoadjuvant androgen deprivation between 1996 and 2000. Cox modeling was used to identify outcome predictors at follow-up landmark points.Higher iPSA was found to be a potent predictor of BR-free survival (P ...
Source: Cancer - August 17, 2009 Category: Cancer & Oncology Authors: James W. Denham, Allison Steigler, Chantelle Wilcox, David S. Lamb, David Joseph, Chris Atkinson, Keen-Hun Tai, Nigel A. Spry, Paul S. Gleeson, Catherine D'Este Source Type: journals

Lymphovascular invasion in rectal cancer following neoadjuvant radiotherapy: a retrospective cohort study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Neoadjuvant radiotherapy does not reduce LVI significantly; however, the prognostic meaning of LVI has changed. Patients with LVI may benefit from neoadjuvant radiotherapy. PMID: 19673022 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 13, 2009 Category: Gastroenterology Authors: Du CZ, Xue WC, Cai Y, Li M, Gu J Tags: World J Gastroenterol Source Type: journals

Chemoradiotherapy in Gastrointestinal MalignanciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Over the past 30 years, significant advances have been made in the integration of radiation therapy and chemotherapy in the treatment of patients with localised gastrointestinal malignancies. The therapeutic goal of chemoradiotherapy is to enhance local control resulting in improved survival and outcome of these patients. To define the optimal sequence, agents and efficacy of these modalities, an array of randomised studies have been conducted in malignancies of the oesophagus, stomach, pancreas, colon, rectum and anus. In oesophageal cancer, recent studies from Germany and France indicate that patients treated w...
Source: Clinical Oncology - August 8, 2009 Category: Radiology Authors: C.G. Willett, B.G. Czito Tags: Gastrointestinal Tumours Source Type: journals

Ratio Between Positive Lymph Nodes and Total Excised Axillary Lymph Nodes as an Independent Prognostic Factor for Overall Survival in Patients with Nonmetastatic Lymph Node-Positive Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our study demonstrates that ALNR is a stronger factor in predicting OS than the absolute number of positive axillary lymph nodes. Content Type Journal ArticleCategory Breast OncologyDOI 10.1245/s10434-009-0653-8Authors Hassan A. Hatoum, American University of Beirut Medical Center Department of Internal Medicine, Division of Hematology/Oncology Beirut LebanonFaek R. Jamali, American University of Beirut Medical Center Department of Surgery, Division of General Surgery Beirut LebanonNagi S. El-Saghir, American University of Beirut Medical Center Department of Internal Medicine, Division of H...
Source: Annals of Surgical Oncology - August 5, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Impact of surgical staging in locally advanced cervical cancer and subsequent chemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Surgical staging (SS) is the gold standard for determination of the true extent of a patient's disease and is an important prognostic factor in cervical cancer. We investigated whether lymph node dissection (LND) prior to chemotherapy (CT) followed by radical surgery (RS) could modified overall (OS) and disease-free survival (DFS).We performed a cohort analysis of 98 patients with cervical carcinoma. The experimental group consisted of 36 patients who underwent SS followed by neoadjuvant chemotherapy, and then by RS (objective response) or chemo-radiation therapy (with or without subsequent surgery when not possible). The ...
Source: Journal of Surgical Oncology - August 2, 2009 Category: Cancer & Oncology Authors: Heitor Ricardo Cosiski Marana, Jurandyr Moreira de Andrade, Francisco José Cândido dos Reis, Daniel Guimarães Tiezzi, Fábio Eduardo Zola, Willan Simões Clagnan, Alexandre Pavan Garieri Source Type: journals

Sarcomas With Spindle Cell MorphologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the days before the term “high-grade undifferentiated pleomorphic sarcoma” came into use, one of the most common sarcoma diagnoses was “malignant fibrous histiocytoma,” and before that, in an era before immunohistochemistry, “fibrosarcoma” was used to describe most sarcomas. “Spindle cell” is a descriptive phrase that denotes the cellular shape of many of the sarcomas encountered in the adult population. As a result, they are usually treated differently from small round cell sarcomas, and have different biological characteristics than those tumors and sarcomas with epithelioid morphology. As a very broad...
Source: Seminars in Oncology - July 31, 2009 Category: Cancer & Oncology Authors: Paola Collini, Poul H.B. Sorensen, Shreyaskumar Patel, Jean-Yves Blay, Rolf D. Issels, Robert G. Maki, Mikael Eriksson, Xavier Garcia del Muro Source Type: journals

Pleural Mesothelioma Patients’ Survival Rate May Improve with Trimodality TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Results from a study reported in the June 20, 2009 issue of the Journal of Clinical Oncology states that the survival rate of patients with pleural mesothelioma may improve following a trimodality therapy treatment approach. Patients with Stage I through Stage III pleural mesothelioma, a rare cancer that affects the lining of the lungs, may benefit from the trimodality approach, which uses three different forms of treatment to combat the cancer. The study evaluated 77 patients with Stage I – III pleural mesothelioma, and began the trimodality therapy approach with neoadjuvant (pre-surgery) chemotherapy using Alimta and P...
Source: Asbestos and Mesothelioma News - July 30, 2009 Category: Environmental Health Authors: JBream Tags: Mesothelioma Mesothelioma Treatment Malignant Mesothelioma Mesothelioma Research Pleural Mesothelioma Source Type: news

POINT: Operative risk of pneumonectomy—Influence of preoperative induction therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A regimen of induction radiation and chemotherapy does not increase the operative mortality of pneumonectomy in carefully selected patients. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - July 22, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Henning A. Gaissert, Dong Yoon Keum, Cameron D. Wright, Marek Ancukiewicz, Eric Monroe, Dean M. Donahue, John C. Wain, Michael Lanuti, James S. Allan, Noah C. Choi, Douglas J. Mathisen Tags: Point/Counterpoint Source Type: journals

Adjuvant chemotherapy after neoadjuvant chemoradiation and surgery: A quest to improve survival for stage II and III rectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Combined multimodality treatments, including radiation, chemotherapy, and total mesorectal excision have been studied extensively over the past few decades, with efforts toward improving rates of locoregional recurrence and disease-free and overall survival in rectal cancer. Predictive and prognostic markers to adjuvant systemic chemotherapy have been identified, with the goal of tailoring therapy and continuing improvement in survival. In our article, we discuss these factors, including tumor downstaging, pathologic node status, gene expression, and future directions in therapy of rectal cancer. ...
Source: Current Colorectal Cancer Reports - July 14, 2009 Category: Cancer & Oncology Tags: Current Colorectal Cancer Reports Source Type: journals