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This page shows you the latest news and research items in this category.

Impact of the introduction of rotavirus vaccine on the timeliness of other scheduled vaccines: The Australian experience.
Abstract Strict age limits for receipt of rotavirus vaccines and simultaneous use of vaccines requiring two (Rotarix(®)) and three (RotaTeq(®)) doses in Australia may impact on coverage and timeliness of other vaccines in the infant schedule. Using data from the Australian Childhood Immunisation Register (ACIR), coverage and timeliness of rotavirus vaccines and changes in timeliness of other infant vaccines following rotavirus vaccine introduction was examined, with particular emphasis on Indigenous infants in whom coverage is less optimal. Final dose rotavirus coverage reached 83% within 21 months of program com...
Source: Vaccine - February 16, 2013 Category: Allergy & Immunology Authors: Hull BP, Menzies R, Macartney K, McIntyre PB Tags: Vaccine Source Type: research

New study highlights Chagas disease as a growing health and socio-economic challenge
(Sabin Vaccine Institute) Today, The Lancet Infectious Diseases published a new report that examines the global economic burden of Chagas disease. In the first study of its kind, researchers measured the health and economic impact of Chagas disease and found that the total economic burden of Chagas disease matches or exceeds that of many more well-known diseases such as rotavirus, Lyme disease and cervical cancer. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 7, 2013 Category: Global & Universal Source Type: news

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Arch Pediatr. 2013 Feb 5; Authors: Aubert M, Beytout J, Callamand P, Cheymol J, Combadière B, Dahlab A, Denis F, Dodet B, Dommergues MA, Gagneur A, Gaillat J, Gavazzi G, Gras-le-Guen C, Haas H, Hau-Rainsard I, Malvy D, de Monléon JV, Picherot G, Pinquier D, Pretet JL, Pulcini C, Rabaud C, Regnier F, Rogeaux O, Savagner C, Soubeyrand B, Valdiguié M, Weil-Olivier C, Groupe Avancées Vaccinales Abstract Every year, the National Foundation for Infectious Diseases brings together more than 300 participants to review progress in vaccine research and development and identify the most promising avenues of research. ...
Source: Archives de Pediatrie - February 5, 2013 Category: Pediatrics Authors: Aubert M, Beytout J, Callamand P, Cheymol J, Combadière B, Dahlab A, Denis F, Dodet B, Dommergues MA, Gagneur A, Gaillat J, Gavazzi G, Gras-le-Guen C, Haas H, Hau-Rainsard I, Malvy D, de Monléon JV, Picherot G, Pinquier D, Pretet JL, Pulcini C, Rabaud C Tags: Arch Pediatr Source Type: research

[Comment] Prediction of immunisation performance
Vaccines are extremely powerful disease prevention agents and have the potential to save millions of lives. Tremendous scientific progress has been made in the past decade with several new vaccines licensed, including those to prevent pneumococcal and rotavirus disease—the two leading killers of young children in developing countries. Thanks to concerted efforts by stakeholders through the GAVI Alliance, many of these new vaccines are now accessible to the lowest-income countries and the children who live there. (Source: LANCET)
Source: LANCET - February 1, 2013 Category: Journals (General) Authors: Celina M Hanson, Eliane Furrer, Nina Schwalbe, Seth Berkley Tags: Comment Source Type: research

Developing country applications of molecular farming: Case studies in South Africa and Argentina.
Abstract Molecular farming is a technology that is very well suited to being applied in developing countries, given the reasonably high level of expertise in recombinant plant development in many centres. In addition, there is an urgent need for products such as inexpensive vaccines and therapeutics for livestock and for some human diseases-and especially those that do not occur or are rare in developed regions. South Africa and Argentina have been at the fore in this area among developing nations, as researchers have been able to use plants to produce experimental therapeutics such as nanoantibodies against rotavi...
Source: Current Pharmaceutical Design - February 1, 2013 Category: Drugs & Pharmacology Authors: Rybicki EP, Hitzeroth II, Meyers A, Dus Santos MJ, Wigdorovitz A Tags: Curr Pharm Des Source Type: research

Rotavirus vaccines. WHO position paper – January 2013.
Authors: PMID: 23424730 [PubMed - in process] (Source: Weekly Epidemiological Record)
Source: Weekly Epidemiological Record - February 1, 2013 Category: Epidemiology Tags: Wkly Epidemiol Rec Source Type: research

An update of "Cost-effectiveness of rotavirus vaccination in the Netherlands: the results of a Consensus Rotavirus Vaccine model"
Conclusions: We concluded that the results on potentially favourable cost-effectiveness in the previous study remain valid, however, the new data suggested that previous results might represent an underestimation of the economic attractiveness of rotavirus vaccination. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - January 30, 2013 Category: Infectious Diseases Authors: Hong TuMark RozenbaumPieter de BoerAlbert NoortMaarten Postma Source Type: research

Rotavirus vaccination in children impacts on adults
Vaccinating children against rotavirus should be encouraged, say researchers, following findings that the prevalence of the disease has recently halved among unvaccinated adults in the USA. (Source: MedWire News - Infectious Diseases)
Source: MedWire News - Infectious Diseases - January 27, 2013 Category: Infectious Diseases Source Type: news

Rotavirus vaccination in children impacts on adults
Vaccinating children against rotavirus should be encouraged, say researchers, following findings that the prevalence of the disease has recently halved among unvaccinated adults in the USA. (Source: MedWire News - Pediatrics)
Source: MedWire News - Pediatrics - January 27, 2013 Category: Pediatrics Source Type: news

Rotavirus Vaccine Given To Children May Indirectly Protect Adults Too
Pediatric rotavirus vaccination also indirectly protects unvaccinated adults from the highly contagious cause of severe diarrhea and vomiting, suggests a new study published in Clinical Infectious Diseases and available online. The findings suggest pediatric immunization against the virus may be more cost effective than previously thought, given rotavirus-related health care costs among adults. Before the vaccine, rotavirus caused an estimated 24 million outpatient visits, 2.4 million hospitalizations, and 453,000 deaths in infants and young children worldwide each year... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 25, 2013 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

"Decade of Vaccines" Blueprint Ignores High Prices, Lacks Ambition on Better-Adapted Vaccines to Help Reach More Children
Sierra Leone 2012 © Lynsey Addario/VII Mothers await vaccinations for their children at the Bumpe Government Clinic in Bo District. Geneva/New York, January 24, 2013—Governments meeting at the World Health Organization’s Executive Board this week must seize the opportunity to improve serious shortcomings in the document that will drive the global community’s vaccines response for the next decade, said the international medical humanitarian organization Doctors Without Borders/Médecins Sans Frontières (MSF). If they fail to do so, some of the key reasons for why millions of child...
Source: MSF News - January 24, 2013 Category: Global & Universal Source Type: news

Rotavirus Vaccine: Protection for the Family (CME/CE)
(MedPage Today) -- Vaccinating children against rotavirus may help prevent disease in adults, too, researchers found. (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - January 24, 2013 Category: Infectious Diseases Source Type: news

Vaccinating children against rotavirus may indirectly protect adults too, study finds
(Infectious Diseases Society of America) Pediatric rotavirus vaccination also indirectly protects unvaccinated adults from the highly contagious cause of severe diarrhea and vomiting, suggests a new study published in Clinical Infectious Diseases and available online. The findings suggest pediatric immunization against the virus may be more cost effective than previously thought, given rotavirus-related health care costs among adults. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 24, 2013 Category: Global & Universal Source Type: news

[Newsdesk] Rotavirus vaccine roll-out
As rotavirus vaccines continue to be introduced in developing and developed countries, Talha Burki looks at the competing forces that determine their benefit. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - January 22, 2013 Category: Infectious Diseases Authors: Talha Burki Tags: Newsdesk Source Type: research

Characterization of human rotaviruses circulating in Iraq in 2008: Atypical G8 and high prevalence of P[6] strains.
Abstract Fecal samples from 976 children with gastroenteritis were collected and analyzed for group A rotavirus (RVA), in three different cities in Iraq between January 2008 and December 2008. RVA antigen was detected in 394 (40%) of the samples, and 98 samples were available for further genotype analyses using multiplex RT-PCR and sequence analyses for untypeable strains. The G/P-genotype combination was determined for 69 samples, and 19, 2 and 8 samples remained P-untypeable, G-untypeable and G/P-untypeable (UT), respectively. The most prevalent genotype was G2 (40%, 39/98) most often associated with P[6]. G1 was...
Source: Infection, Genetics and Evolution - January 20, 2013 Category: Genetics & Stem Cells Authors: Ahmed S, Klena J, Albana A, Alhamdani F, Oskoff J, Soliman M, Heylen E, Teleb N, Husain T, Matthijnssens J Tags: Infect Genet Evol Source Type: research

A model result for rotavirus vaccination in Turkey
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - January 17, 2013 Category: Health Management Tags: Research article Source Type: research

Uptake of oral rotavirus vaccine and timeliness of routine immunization in Brazil's National Immunization Program.
CONCLUSION: To maximize benefits of rotavirus vaccination, strategies are needed to improve timeliness of routine immunizations; monitoring rotavirus vaccine uptake and intussusception risk is needed to guide further recommendations for rotavirus vaccination. PMID: 23313652 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - January 10, 2013 Category: Allergy & Immunology Authors: Flannery B, Samad S, de Moraes JC, Tate JE, Danovaro-Holliday MC, de Oliveira LH, Rainey JJ Tags: Vaccine Source Type: research

Global Immunization Vision and Strategy (GIVS): a mid-term analysis of progress in 50 countries
Within the overall framework set out in the Global Immunization Vision and Strategy (GIVS) for the period 2006–2015, over 70 countries had developed comprehensive Multi-Year Plans (cMYPs) by 2008, outlining their plans for implementing the GIVS strategies and for attaining the GIVS Goals at the midpoint in 2010 or earlier. These goals are to: (1) reach ≥90% and ≥80% vaccination coverage at national and district level, respectively; and (2) reduce measles-related mortality by 90% compared with the 2000 level. Fifty cMYPs were analysed along the four strategic areas of the GIVS: (1) protecting more people in a ch...
Source: Health Policy and Planning - January 7, 2013 Category: Health Management Authors: Kamara, L., Lydon, P., Bilous, J., Vandelaer, J., Eggers, R., Gacic-Dobo, M., Meaney, W., Okwo-Bele, J.-M. Tags: Original articles Source Type: research

Tanzania: 10,000 Sumbawanga Children to Get Diarrhoea, Pneumonia Vaccinations
[Daily News]Sumbawanga -A TOTAL of 9,959 children below the age of five years in Sumbawanga Municipality in Rukwa Region will be vaccinated against Rotavirus diarrhoea and Pneumonia, the Municipal Medical in-Charge, Dr Ally Makori Mussa, disclosed. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 6, 2013 Category: African Health Source Type: news

Tanzania: Kagera Children to Be Vaccinated
[Daily News]Bukoba -A TOTAL of 109,407 children aged below five in Kagera Region will be vaccinated against Rotavirus diarrhoea and Pneumonia, Acting Kagera Regional Medical Officer (RMO) Dr Salum Sufian has disclosed. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 6, 2013 Category: African Health Source Type: news

Tanzania: Kagera Vaccinates Children
[Daily News]A TOTAL of 109,407 children aged below the age of five years in Kagera Region will be vaccinated against Rotavirus diarhoea and Pneumonia, the Acting Kagera Regional Medical Officer (RMO), Dr Salum Sufian disclosed. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 6, 2013 Category: African Health Source Type: news

Africa: Unicef Tender Supports Middle Income Country Access to Affordable New Vaccines
[Unicef]Copenhagen -To help improve global access to new vaccines that protect children against the leading killers of pneumonia and diarrhoea, UNICEF is inviting manufacturers to participate in a tender that will help establish affordable, sustainable supplies of Pneumococcal conjugate and Rotavirus vaccines for Middle Income Countries from 2013 to 2015. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 4, 2013 Category: African Health Source Type: news

Winter vomiting bug cases 72 per cent higher than this time last year
Further surge expected over next few weeksRelated items from OnMedicaTexting can improve flu jab uptakeOlder people eating food past its sell by dateAlso in the pressUK rotavirus vaccination programme for next yearMalaria cases rise sharply (Source: OnMedica Latest News)
Source: OnMedica Latest News - January 3, 2013 Category: UK Health Source Type: news

[Management of acute diarrhea in children].
Abstract Diarrhea in childhood is very frequent (two episodes/year/children less of 5 years), rarely fatale (mostly mild) and not requiring additional exploration. But it can justify a hospitalization in case of dehydration (delay of care) or risk of dehydration. It is mainly of viral origin (rotavirus +++) and it has for main complication dehydration. Diagnosis and evaluation of the dehydration, in percentage of loss of weight, must be fast and lead (drive) to a premature correction of hypovolumic shock (or to an accurate fluid management). Main treatment is oral rehydration solutions (ORS), which considerably up...
Source: Presse Medicale - January 1, 2013 Category: Journals (General) Authors: Van Trieu T, De Pontual L Tags: Presse Med Source Type: research

Development of a stable insect cell line constitutively expressing rotavirus VP2.
Abstract An insect High-Five cell line was generated constitutively and stably expressing the VP2 protein of rotavirus RF strain leading to the formation of core-like particles. The integration of the VP2 gene was confirmed by PCR, Real-time PCR and Southern blot, and the protein expression was confirmed by Western blot and immunofluorescence microscopy. Integrity and self assembly of VP2 as core-like particles was demonstrated by electron microscopy. The High-Five cell system stably expressing rotavirus core-like particles can be applied to the study of viral protein structure and functions; it may be useful for v...
Source: Virus Research - December 31, 2012 Category: Virology Authors: Shoja Z, Tagliamonte M, Jalilvand S, Mokhtari-Azad T, Hamkar R, Shahmahmoodi S, Rezaei F, Tornesello M, Buonaguro FM, Buonaguro L, Nategh R Tags: Virus Res Source Type: research

New rotavirus strains may hit India's vaccination plans
Strains of rotavirus earlier found only in animals are now infecting human beings. (Source: SciDev.Net)
Source: SciDev.Net - December 28, 2012 Category: Global & Universal Source Type: news

Tanzania: PM Touts Vaccine for Children
[Daily News]PREMIER Mizengo Pinda has pleaded with all Tanzanians to take their children for Pneumococcal and Rotavirus vaccinations set to start early next year. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 26, 2012 Category: African Health Source Type: news

Vaccine preventable viral diseases and risks associated with waterborne transmission.
Abstract Rotavirus and poliovirus are paradigmatic viruses for causing major diseases affecting the human population. The impact of poliovirus is remarkably diminished because of vaccination during the last half century. Poliomyelitis due to wild polio currently affects a limited number of countries, and since 2000 sporadic outbreaks have been associated to neurovirulent vaccine-derived polioviruses. Conversely, rotavirus is presently very diffuse, accounting for the largest fraction of severe gastroenteritis among children <5 years-old. Vaccination towards rotavirus is still in its dawn, and zoonotic strains co...
Source: Annali dell'Istituto Superiore di Sanita - December 22, 2012 Category: Global & Universal Authors: Ruggeri FM, Fiore L Tags: Ann Ist Super Sanita Source Type: research

A Dual Chicken IgY Against Rotavirus and Norovirus.
In this study, we developed a dual IgY against both RV and NoV through immunization of chickens with a divalent vaccine comprising neutralizing antigens of both RV and NoV. This divalent vaccine, named P-VP8∗ particle, is made of the NoV P particle as a carrier with the RV spike protein VP8∗ as a surface insertion. Approximately 45 mg of IgY were readily obtained from each yolk with high titers of anti-P particle and anti-VP8∗ antibodies detected by ELISA, Western blot, HBGA blocking (NoV and RV) and neutralization (RV) assays. Reductions of RV replication were observed with viruses treated with the IgY before and af...
Source: Antiviral Research - December 22, 2012 Category: Virology Authors: Dai YC, Zhang XF, Tan M, Huang P, Lei W, Fang H, Zhong W, Jiang X Tags: Antiviral Res Source Type: research

Adoption of Rotavirus Vaccine by U.S. Physicians: Progress and Challenges
Background: Pentavalent rotavirus vaccine (RV5) was recommended for routine use in 2006 followed by monovalent rotavirus vaccine (RV1) in 2008. Purpose: To describe, among a U.S. sample of pediatricians (n=289 respondents) and family medicine physicians (n=243 respondents), (1) current practices regarding rotavirus vaccine (RV) and barriers to use with comparison to a 2007 survey and (2) knowledge of recent safety concerns regarding RV1 and their impact on its use. Methods: A mail and Internet survey was conducted with the physicians, from November 2010 to January 2011; analyses were conducted March–September 2011. ...
Source: American Journal of Preventive Medicine - December 19, 2012 Category: Global & Universal Authors: Sean T. O'Leary, Umesh D. Parashar, Lori A. Crane, Mandy A. Allison, Shannon Stokley, Brenda L. Beaty, Michaela Brtnikova, Laura P. Hurley, Allison Kempe Tags: Research Articles Source Type: research

Rotavirus W179-9 vaccine: Ileostomy fluid loss (first report) in an infant: case report
(Source: Reactions)
Source: Reactions - December 17, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

What Are Common Presentations of Primary Immunodeficiencies?
Discussion Of the various primary immunodeficiencies (PIDs), primary antibody deficiencies are the most common. B-cell deficiencies that occur early in the maturational process (i.e. Bruton’s or X-linked agammaglobulinaemia) tend to be more severe than those that occur later (selective IgA and IgG subclass deficiencies.) X-linked agammaglobulinaemia (XLA) was first described by Bruton in 1952 and is caused by the gene BTK, a protein tyrosine kinase that blocks B-cell maturation resulting in severely decreased B-cells and all classes of antibodies. Female carriers are asymptomatic generally and males have clinical ma...
Source: PediatricEducation.org - December 16, 2012 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Pharmacoeconomic Spotlight on Rotavirus Vaccine RIX4414 (Rotarix) in Developed Countries
This article is currently available as a free download on ingentaconnect (Source: Drugs in R)
Source: Drugs in R - December 13, 2012 Category: Drugs & Pharmacology Authors: Plosker, Greg L. Tags: Adis Spotlight Source Type: research

The evolving epidemiology of rotavirus gastroenteritis in central Portugal with modest vaccine coverage
Conclusions: Our results demonstrate fluctuations in RVAG incidence with no clear progressive trends or seasonal RV shifts among our surveillance subjects over five years, in the context of limited rotavirus vaccine coverage. Significant annual changes in genotype distributions were detected. Higher vaccine coverage may be necessary than at present for consistent impact on disease. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - December 13, 2012 Category: Virology Authors: Fernanda Rodrigues, Miren Iturriza-Gómara, Robin Marlow, Jim Gray, Sameena Nawaz, Luís Januário, Adam Finn Tags: Full length articles Source Type: research

New vaccinations on the horizon under consideration by the JCVI
Source: Vaccine Update Area: News The most recent issue of Vaccine Update from the Department of Health acknowledges recent articles in the media regarding new vaccinations or vaccination timings that may be under consideration for introduction into the UK schedule in the future. In addition to rotavirus, which is anticipated to be available for use as part of the routine childhood vaccination schedule by early autumn in 2013, these include the following: 1. Shingles for people aged 70 and up to 79 The Joint Committee on Vaccination and Immunisation (JCVI) advised in 2010 that a national shingles vaccina...
Source: NeLM - News - December 10, 2012 Category: Drugs & Pharmacology Source Type: news

Molecular epidemiology of noroviruses associated with acute sporadic gastroenteritis in children: Global distribution of genogroups, genotypes and GII.4 variants
Abstract: Noroviruses are a leading cause of epidemic and sporadic acute gastroenteritis worldwide. The development of sensitive molecular diagnostic techniques has revolutionized our understanding of norovirus epidemiology over the past two decades, but norovirus strain types associated with sporadic gastroenteritis remain poorly described. Therefore, we conducted a systematic review of studies performed after 2000 to clarify the genotypic distribution of noroviruses in children (≤18 years of age) with sporadic acute gastroenteritis. Genogroup GII norovirus was the most prevalent, accounting for 96% of all sporadic infe...
Source: Journal of Clinical Virology - December 7, 2012 Category: Virology Authors: T.N. Hoa Tran, Eamonn Trainor, Toyoko Nakagomi, Nigel A. Cunliffe, Osamu Nakagomi Tags: Full length articles Source Type: research

MSF at the GAVI Alliance "Partners Forum" Vaccination Conference, Tanzania, December 57, 2012
DRC 2008 © Anna Surinyach An MSF staff member vaccinates a child for measles. Three new issue briefs outlining Doctors Without Borders/Médecins Sans Frontières (MSF)’s main concerns regarding the need for adapted vaccines, the need to bring vaccine prices down, and the need to address vaccine supply problems can be accessed at: msfaccess.org/briefings. “There’s no reason children should still be dying of vaccine-preventable diseases. The global vaccines community could be doing a lot better to make sure all babies in developing countries are fully vaccinated against killer d...
Source: MSF News - December 4, 2012 Category: Global & Universal Source Type: news

Australia's contribution to global immunisation.
Conclusions : Australian contributions to vaccines and immunisation have been substantial, and Australia offers a range of good practices in its domestic and development approaches. There are major opportunities to build on this strong track record. These include committing to help roll out important new life-saving vaccines against pneumococcal disease, rotavirus and human papilloma virus (HPV) to the children who need them most, but whose communities can least afford them. Implications : Australia is one of a few countries expanding their aid budgets towards 0.7% development assistance and other development commitments. ...
Source: Australian and New Zealand Journal of Public Health - December 1, 2012 Category: Global & Universal Authors: Ruff TA, Taylor K, Nolan T Tags: Aust N Z J Public Health Source Type: research

Vaccines for preventing rotavirus diarrhoea: vaccines in use.
CONCLUSIONS: RV1 and RV5 prevent episodes of rotavirus diarrhoea. The vaccine efficacy is lower in high-mortality countries; however, due to the higher burden of disease, the absolute benefit is higher in these settings. No increased risk of serious adverse events including intussusception was detected, but post-introduction surveillance studies are required to detect rare events associated with vaccination. PMID: 23152260 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - November 28, 2012 Category: Journals (General) Authors: Soares-Weiser K, Maclehose H, Bergman H, Ben-Aharon I, Nagpal S, Goldberg E, Pitan F, Cunliffe N Tags: Cochrane Database Syst Rev Source Type: research

Jabs for babies: Pig virus-contaminated vaccine for stomach virus to be administered to small infants in UK
The push is on to get as many newborn babies as possible vaccinated for rotavirus in the U.K., as health officials unveil a new vaccine program that they claim will reduce hospital admissions for the stomach bug. BBC News reports that the U.K. Department of Health will... (Source: NaturalNews.com)
Source: NaturalNews.com - November 26, 2012 Category: Consumer Health Advice Source Type: news

[Immunisation schedule of the Spanish Association of Paediatrics: 2013 Recommendations.]
Comité Asesor de Vacunas de la Asociación Española de Pediatría, España Abstract The Advisory Committee on Vaccines of the Spanish Association of Paediatrics (CAV-AEP) updates the immunisation schedule every year, taking into account epidemiological data as well as evidence on the safety, effectiveness and efficiency of vaccines. The present schedule includes levels of recommendation. We have graded as routine vaccinations those that the CAV-AEP consider all children should receive; as recommended those that fit the profile for universal childhood immunisation and would ideally be given to all children, but t...
Source: Anales de Pediatria - November 24, 2012 Category: Pediatrics Authors: Moreno-Pérez D, Alvarez García FJ, Arístegui Fernández J, Barrio Corrales F, Cilleruelo Ortega MJ, Corretger Rauet JM, González-Hachero J, Hernández-Sampelayo Matos T, Merino Moína M, Ortigosa Del Castillo L, Ruiz-Contreras J, en representación de Tags: An Pediatr (Barc) Source Type: research

A time-resolved immunoassay to measure serum antibodies to the rotavirus VP6 capsid protein.
This study demonstrates the suitability of using recombinant proteins to measure anti-RV immune responses and serves as a "proof of principle" to examine the antibody responses generated to other recombinant RV proteins and thereby possibly identify a correlate of protection. PMID: 23183143 [PubMed - as supplied by publisher] (Source: Journal of Virological Methods)
Source: Journal of Virological Methods - November 23, 2012 Category: Virology Authors: Kavanagh O, Zeng XL, Ramani S, Mukhopadhya I, Crawford SE, Kang G, Estes MK Tags: J Virol Methods Source Type: research

One Of My Favorite Charts On The Power Of Vaccines
I'm posting this because I found the graphic in a file folder on my computer and didn't want to lose it. It's originally from my profile of Bill Gates from last year's Forbes Power List issue. The data (and the original version of the graph) come from the New England Journal of Medicine. This is a graph of what happened when the vaccine against rotavirus, a major cause of infant diarrhea, was introduced in Mexico. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - November 20, 2012 Category: Pharmaceuticals Authors: Matthew Herper Source Type: news

Dose sparing and enhanced immunogenicity of inactivated rotavirus vaccine administered by skin vaccination using a microneedle patch.
Abstract Skin immunization is effective against a number of infectious diseases, including smallpox and tuberculosis, but is difficult to administer. Here, we assessed the use of an easy-to-administer microneedle (MN) patch for skin vaccination using an inactivated rotavirus vaccine (IRV) in mice. Female inbred BALB/c mice in groups of six were immunized once in the skin using MN coated with 5μg or 0.5μg of inactivated rotavirus antigen or by intramuscular (IM) injection with 5μg or 0.5μg of the same antigen, bled at 0 and 10 days, and exsanguinated at 28 days. Rotavirus-specific IgG titers increased over time ...
Source: Vaccine - November 19, 2012 Category: Allergy & Immunology Authors: Moon S, Wang Y, Edens C, Gentsch JR, Prausnitz MR, Jiang B Tags: Vaccine Source Type: research

More vaccines please; we're British!
In the UK, the Department of Health has announced that all children will receive a vaccination for Rotavirus beginning in September 2013; bringing the number of vaccines administered by the age of one to a staggering 24. Rotavirus causes diarrhea, vomiting and intestinal... (Source: NaturalNews.com)
Source: NaturalNews.com - November 16, 2012 Category: Consumer Health Advice Source Type: news

Molecular characterization of rotavirus isolates from select Canadian pediatric hospitals
Conclusions: Although a limited number of samples were obtained from a median of 4 centres during the 4 years of the study, it appears that currently approved rotavirus vaccines are well matched to the rotavirus genotypes identified at these hospitals. Further surveillance to monitor the emergence of rotavirus genotypes in Canada is warranted. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - November 15, 2012 Category: Infectious Diseases Authors: Andrew McDermidNicole Le SauxElsie GrudeskiJulie BettingerKathy ManguiatScott HalperinLily MacDonaldPierre DéryJoanne EmbreeWendy VaudryTimothy Booth Source Type: research

Genetic and antigenic evolution profiles of G1 rotaviruses in Córdoba, Argentina, during a 27‐year period (1980–2006)
Abstract Rotavirus G1 strains represent the most common genotype that causes diarrhea in humans and has been incorporated into both, monovalent and multivalent, rotavirus licensed vaccines. The aim of this study was to determine the evolution profile of G1 rotaviruses in Córdoba, Argentina, over a 27‐year period (1980–2006). Intragenotype diversity, represented by lineages within rotavirus circulating strains, was observed. Phylogenetic analysis of the VP7‐gene of G1 rotavirus clinical strains showed the circulation of G1 lineage IV and V strains in the 1980s, and co‐circulation of lineage I and II strains in the ...
Source: Journal of Medical Virology - November 14, 2012 Category: Virology Authors: Patricia Barril, Laura Martínez, Miguel Giordano, Gisela Masachessi, María Isa, Jorge Pavan, Graciela Glikmann, Silvia Nates Tags: Research Article Source Type: research

Molecular characterization of serotype G9 rotaviruses circulating in South Korea between 2005 and 2010
Abstract A total of 18 rotavirus G9 strains in South Korea were collected during five rotavirus seasons between 2005 and 2010. The relationship between these strains was examined by analyzing the genetic variation of two major structural genes, VP7 and VP4. All the rotavirus isolates were of the G9P[8] genotype. The VP7 phylogenetic analysis demonstrated that all of the G9 rotaviruses circulating in South Korea belonged to lineage IIId and were within three single clusters. The amino acid comparison of the antigenic regions of the VP7 gene suggests possible common progenitors of these strains. Phylogenetic analysis of P[8]...
Source: Journal of Medical Virology - November 14, 2012 Category: Virology Authors: Van Thai Than, Hyeonji Kang, Inseok Lim, Wonyong Kim Tags: Research Article Source Type: research

Determinants of parents' decision to vaccinate their children against rotavirus: results of a longitudinal study
Rotavirus disease is a common cause of health care utilization and almost all children are affected by the age of 5 years. In Canada, at the time of this survey (2008–09), immunization rates for rotavirus were <20%. We assessed the determinants of a parent’s acceptance to have their child immunized against rotavirus. The survey instruments were based on the Theory of Planned Behavior. Data were collected in two phases. In all, 413 and 394 parents completed the first and second interviews, respectively (retention rate 95%). Most parents (67%) intended to immunize their child against rotavirus. Factors signifi...
Source: Health Education Research - November 14, 2012 Category: Research Authors: Dube, E., Bettinger, J. A., Halperin, B., Bradet, R., Lavoie, F., Sauvageau, C., Gilca, V., Boulianne, N. Tags: ORIGINAL ARTICLES Source Type: research

Babies To Be Protected Against Common Diarrhoea Bug
Thousands of young children will be spared hospital stays and hundreds of thousands of GP visits caused by diarrhoea thanks to a new vaccination programme, announced today by the Department of Health. The programme, which is planned to begin in September next year, will see children under four months vaccinated against rotavirus - a highly infectious bug that causes around 140,000 diarrhoea cases a year in under fives. It leads to hospital stays for nearly one in ten - around 14,000 - of those who get it in the UK... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 13, 2012 Category: Consumer Health News Tags: Pediatrics / Children's Health Source Type: news