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Milestone biodefense publication by Elsevier journal VaccineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Elsevier) Last week during the Vaccines for Biothreats and Emerging and Neglected Diseases Symposium in Galveston Texas, the Elsevier journal Vaccine released a supplement dedicated to vaccines for biodefense. This publication provides a comprehensive, state-of-the-art overview on vaccines that have been developed against a diverse group of human and veterinary pathogens, including Bacillus anthracis, smallpox and blue tongue. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 19, 2009 Category: Global & Universal Source Type: news

Facebook crowdsourced investigation exposes vaccine denials of SIGA TechnologiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) When you publish a hard-hitting story containing links to lots of little-known documents, you never know what kind of bizarre blow-back you'll receive. The latest episode of reactive strangeness occurred following our publication of the story about SIGA Technologies and the conflicts of interest found in Dr. Mehmet Oz's holding of 150,000 option shares in that company (http://www.naturalnews.com/027451_Dr_Mehmet_Oz_vaccines.html) even while pushing vaccines on TV. Shortly after publishing this article, NaturalNews was contacted by a public relations firm called KCSA Strategic Communications, which represents ...
Source: NaturalNews.com - November 13, 2009 Category: Consumer Health Advice Source Type: news

Laboratory-Acquired Vaccinia Virus Infection -- Virginia, 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This case report supports current US recommendations for smallpox vaccination at least every 10 years for laboratory workers at high risk of vaccinia virus infection. Morbidity & Mortality Weekly Report (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - November 11, 2009 Category: Allergy & Immunology Tags: Public Health & Prevention Source Type: info

H1N1 vaccines too little, too late; most people already exposed and immune (opinion)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) The Big Pharma frenzy over H1N1 vaccines has turned into a circus of hilarious medical quackery thanks to the fact that by the time the vaccines are available, most people will have already been exposed to the virus. Hence, most people will have already built up their own H1N1 antibodies, rendering the vaccine not just useless, but downright laughable.Even with the outlandish rush to get these vaccines approved by the FDA -- a hurry that saw the complete abandonment of the principles of "scientific testing" -- Big Pharma just couldn't get these vaccines produced quickly enough to beat the virus itself. Taking...
Source: NaturalNews.com - November 6, 2009 Category: Consumer Health Advice Source Type: news

A mouse-based assay for the pre-clinical neurovirulence assessment of vaccinia virus-based smallpox vaccines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Post-vaccinal encephalitis, although relatively uncommon, is a known adverse event associated with many live, attenuated smallpox vaccines. Although smallpox vaccination ceased globally in 1980, vaccine manufacture has resumed in response to concerns over the possible use of smallpox virus as an agent of bioterrorism. To better support the production of safer smallpox vaccines, we previously reported the development of a mouse model in which a relatively attenuated vaccine strain (Dryvax((R))) could be discerned from a more virulent laboratory strain (WR). Here we have further tested the performance of this assay by ev...
Source: Biologicals : Journal of the International Association of Biological Standardization - November 5, 2009 Category: Biotechnology Authors: Zhang CX, Sauder C, Malik T, Rubin SA Tags: Biologicals Source Type: journals

Vaccines as a trigger for myopathies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vaccines are considered to be among the greatest medical discoveries, credited with the virtual eradication of some diseases and the consequent improved survival and quality of life of the at-risk population. With that, vaccines are among the environmental factors implicated as triggers for the development of inflammatory myopathies. The sporadic reports on vaccine-induced inflammatory myopathies include cases of hepatitis B virus, bacillus Calmette-Guérin, tetanus, influenza, smallpox, polio, diphtheria, diphtheria-pertussis-tetanus, combination of diphtheria with scarlet fever and diphtheria-pertussis-tetanus wi...
Source: Lupus - November 1, 2009 Category: Rheumatology Authors: Orbach H, Tanay A Tags: Lupus Source Type: journals

Smallpox vaccines for biodefense.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Few diseases can match the enormous impact that smallpox has had on mankind. Its influence can be seen in the earliest recorded histories of ancient civilizations in Egypt and Mesopotamia. With fatality rates up to 30%, smallpox left its survivors with extensive scarring and other serious sequelae. It is estimated that smallpox killed 500 million people in the 19th and 20th centuries. Given the ongoing concerns regarding the use of variola as a biological weapon, this review will focus on the licensed vaccines as well as current research into next-generation vaccines to protect against smallpox and other poxviruses. ...
Source: Vaccine - October 22, 2009 Category: Allergy & Immunology Authors: Kennedy RB, Ovsyannikova I, Poland GA Tags: vaccine Source Type: journals

CDC: Vaccines a public health successEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ATLANTA, Oct. 20 (UPI) -- Vaccines are one of the greatest success stories in public health, having eliminated smallpox and nearly rid the world of polio, U.S. health officials said. (Source: Health News - UPI.com)
Source: Health News - UPI.com - October 20, 2009 Category: Consumer Health News Source Type: news

Outfoxing Pox: Developing A New Class Of Vaccine CandidatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists have taken a fresh look at cowpox. Their findings demonstrate that this ancient pathogen still has much to teach us, and may hasten development of novel vaccines against smallpox and other pox-like diseases. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 17, 2009 Category: Science Source Type: news

Outfoxing Pox: Developing A New Class Of Vaccine CandidatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the annals of medicine, Edward Jenner's 1796 vaccination of a young boy against smallpox, using fluid from cowpox blisters, remains a landmark case. In a new study, Kathryn Sykes, a researcher at Arizona State University's Biodesign Institute and her colleagues have taken a fresh look at cowpox. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 16, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Flu vaccines revealed as the greatest quackery ever pushed in the history of medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) Prepare to have your world rocked. What you're about to read here will leave you astonished, inspired and outraged all at the same time. You're about to be treated to some little-known information demonstrating why seasonal flu vaccines are utterly worthless and why their continued promotion is based entirely on fabricated studies and medical mythology.If the whole world knew what you're about to read here, the vaccine industry would collapse overnight.This information comes to you courtesy of a brilliant article published in The Atlantic (November 2009). The article, written by Shannon Brownlee and Jeanne Le...
Source: NaturalNews.com - October 14, 2009 Category: Consumer Health Advice Source Type: news

Outfoxing pox: Developing a new class of vaccine candidatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Arizona State University) In a new study, Kathryn Sykes, a researcher at Arizona State University's Biodesign Institute and her colleagues have taken a fresh look at cowpox. Their findings, appearing in the advanced online issue of Virology, demonstrate that this ancient pathogen still has much to teach us, and may hasten development of novel vaccines against smallpox and other pox-like diseases. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 14, 2009 Category: Infectious Diseases Source Type: news

Smallpox vaccine: Myopericarditis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 12, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Historical Data Shows Vaccines are Not what Saved UsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) With all of the hype surrounding the H1N1 swine flu virus lately, everyone is very concerned with the safety and effectiveness of vaccines, and rightly so. This is a very important question that we must all ask ourselves and find out what the truth is. As the debate rages on an even more important question has rarely been asked. Do vaccines even protect you from the viruses and illnesses that they claim to?If you only get your news and information from mainstream news and educational sources, then the question about whether vaccines are effective is never even raised. This lack of discussion give the percepti...
Source: NaturalNews.com - October 9, 2009 Category: Consumer Health Advice Source Type: news

New classes of orthopoxvirus vaccine candidates by functionally screening a synthetic library for protective antigens.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The licensed smallpox vaccine, comprised of infectious vaccinia, is no longer popular as it is associated with a variety of adverse events. Safer vaccines have been explored such as further attenuated viruses and component designs. However, these alternatives typically provide compromised breadth and strength of protection. We conducted a genome-level screening of cowpox, the ancestral poxvirus, in the broadly immune-presenting C57BL/6 mouse as an approach to discovering novel components with protective capacities. Cowpox coding sequences were synthetically built and directly assayed by genetic immunization for open-re...
Source: Virology - September 29, 2009 Category: Virology Authors: Borovkov A, Magee DM, Loskutov A, Cano JA, Selinsky C, Zsemlye J, Lyons CR, Sykes K Tags: Virology Source Type: journals

When Does the Rash of Roseola Occur?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion Rashes, particularly ones caused by viruses, are common presenting problems. In his first edition of Pediatrics, Dr. Rotch spent 72 pages describing infectious exanthemata. The cause of the exanthemata was unknown at the time, and thankfully many of those that he wrote of have been eradicated (smallpox), have effective vaccines to prevent (measles, rubella, varicella) or effective antibiotics for treatment (streptococcus). Dr. Rotch ends his extensive treatise with a table describing “the chief points of differential diagnosis in the exanthemata.” This is what was state-of-the-art in 1896 with his s...
Source: PediatricEducation.org - September 28, 2009 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: info

If AIDS Went the Way of SmallpoxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite a promising and expensive study, a vaccine is not around the corner, and no expert will say it is. (Source: NYT > Health)
Source: NYT > Health - September 26, 2009 Category: Consumer Health News Authors: By DONALD G. McNEIL Jr. Tags: Acquired Immune Deficiency Syndrome vaccination and Immunization Thailand Medicine and Health Source Type: news

Boosting Vaccines: The Power of Adjuvants (preview)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The thought of birth defects caused by rubella, rows of iron lungs housing children crippled by polio, or the horrific sound of a baby struggling with whooping cough can still evoke dread among people who have seen firsthand the damage inflicted by these and other vaccine-preventable diseases. Fortunately, those scourges are virtually unknown to modern generations that have had access to vaccines all their lives.For more than 200 years vaccines have proved to be one of the most successful, lifesaving and economical methods of preventing infectious disease, second only to the sanitization of water. Vaccines have spared mill...
Source: Scientific American - Official RSS Feed - September 23, 2009 Category: Science Tags: Biology,Chemistry,Health,Technology,What ' s Next,Science in Service Source Type: journals

ImmunizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Immunization against infectious agents to induce a specific, protective immune response can be achieved actively or passively.Passive immunization is the administration of preformed protective antibodies; this immunity is short lived. Active immunization involves the administration of antigens to induce humoral and/or cell-mediated immune responses to a specific micro-organism; this provides more enduring immunity. The first description of active immunization is attributed to Edward Jenner, who, in 1796, induced protective immunity to smallpox by inoculating cowpox (vaccinia) vesicle fluid into the skin of suscep...
Source: Medicine - September 22, 2009 Category: Internal Medicine Authors: Matthijs Backx, Andrew Freedman Tags: Defence against infection Source Type: journals

ST-246(R) inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Orthopoxvirus infections, such as smallpox, can lead to severe systemic disease and result in considerable morbidity and mortality in immunologically naïve individuals. Treatment with ST-246(R), a small molecule inhibitor of virus egress, has been shown to provide protection against severe disease and death induced by several members of the poxvirus family, including vaccinia, variola, and monkeypox viruses. Here we show that ST-246 treatment not only results in the significant inhibition of vaccinia virus dissemination from the site of inoculation to distal organs, such as the spleen and liver, but it also reduce...
Source: Antimicrobial Agents and Chemotherapy - September 13, 2009 Category: Microbiology Authors: Berhanu A, King DS, Mosier S, Jordan R, Jones KF, Hruby DE, Grosenbach DW Tags: Antimicrob Agents Chemother Source Type: journals

NFkappaB inhibitors: Strategies from poxviruses.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The orchestration of the inflammatory responses to both infection and tissue damage is arguably the key physiological function of NFkappaB, and thus interference with the activation of NFkappaB represents an exceptional strategy for a successful pathogen to exploit to counter multiple host innate defense processes through the targeting of a single host regulatory pathway. Because of their large genomes, which typically encode approximately 200 proteins, and their unusual independence from the host nuclear transcriptional machinery, poxviruses are especially well suited to manipulate the cytoplasmic activation of NFkapp...
Source: Cell Cycle - September 11, 2009 Category: Cytology Authors: Mohamed MR, McFadden G Tags: Cell Cycle Source Type: journals

Risk of lymphoma and leukaemia after bacille Calmette-Guérin and smallpox vaccination: A Danish case-cohort study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective was to examine the effects of BCG and smallpox vaccinations on subsequent risk of lymphoma and leukaemia in a Danish population experiencing rapid out-phasing of these vaccines. In a background cohort (N=47,622) from the Copenhagen School Health Records Register, cases of leukaemia (N=20) and lymphoma (N=51) were identified through the Danish Cancer Registry. The vaccination status of the cases was compared with the vaccination status of a 5% random sample (N=2073) of the background cohort and analysed in a case-cohort design. BCG vaccination reduced the risk of lymphomas (HR=0.49 (95% CI: 0.26-0.93)), wherea...
Source: Vaccine - September 7, 2009 Category: Allergy & Immunology Authors: Villumsen M, Sørup S, Jess T, Ravn H, Relander T, Baker JL, Benn CS, Sørensen TI, Aaby P, Roth A Tags: vaccine Source Type: journals

SIGA Technologies Receives a $3 Million Research Grant From the National Institutes of HealthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW YORK, Sept. 2, 2009 (GLOBE NEWSWIRE) -- SIGA Technologies, Inc. (Nasdaq:SIGA), a company specializing in the development of pharmaceutical agents to fight bio-warfare pathogens, today announced that it has received a Phase II grant of approximately $3 million from the National Institutes of Health (NIH), to continue exploring the use of ST-246(r) as an adjunct to the current smallpox vaccine for prevention of smallpox vaccine-related adverse events. (Source: Medical News (via PRIMEZONE))
Source: Medical News (via PRIMEZONE) - September 2, 2009 Category: Pharmaceuticals Source Type: news

Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response [Immunology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eczema vaccinatum (EV) is a complication of smallpox vaccination occurring in patients with atopic dermatitis. In affected individuals, vaccinia virus... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 31, 2009 Category: Science Authors: Oyoshi, M. K., Elkhal, A., Kumar, L., Scott, J. E., Koduru, S., He, R., Leung, D. Y. M., Howell, M. D., Oettgen, H. C., Murphy, G. F., Geha, R. S. Tags: Immunology Source Type: journals

Historical facts about the dangers (and failures) of vaccinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) Vaccines are the quackery of modern medicine. Mass vaccination programs not only fail to protect the population from infectious disease, they actually accelerate the spread of disease in many cases.Many website have cropped up over the last few years to counter the pro-vaccine propaganda put out by drug companies (who profit from vaccines) and health regulators (who serve the drug companies). One of those sites is www.VaccinationDebate.com , which lists the following historical facts about vaccines:• In the USA in 1960, two virologists discovered that both polio vaccines were contaminated with the SV 40 ...
Source: NaturalNews.com - August 29, 2009 Category: Consumer Health Advice Source Type: news

Bioterrorism and Infectious AgentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A New Dilemma for the 21st Century series: Emerging Infectious Diseases of the 21st Century This volume in the series Emerging Infectious Diseases of the 21st Century provides the most up-to-date and comprehensive information available on bioterrorism agents such as:Anthrax, smallpox, plague, and SARS Vaccine development New anti-viral drug development Treatment and protection Threat analysis and response Biological and chemical agents Compiled by two of the leading ... (Source: Springer Medicine titles)
Source: Springer Medicine titles - August 20, 2009 Category: Databases & Libraries Tags: Infectious Diseases Source Type: organizations

Governments, off-patent vaccines, smallpox and universal childhood vaccination.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
WHO is now celebrating 30 years of freedom from smallpox. What was originally seen as a victory over an ancient scourge can now be viewed as an epidemiologically driven programme to overcome governmental inertia and under-achievement in delivering an off-patent vaccine. Though efforts are accelerating global vaccine use, a plea is made to push the world's governments to commit to universal childhood vaccination via a proposed new programme. The latter should begin by exploiting a long list of ever more affordable off-patent vaccines, vaccines that can virtually eliminate the bulk of the world's current vaccine-preventa...
Source: Vaccine - August 18, 2009 Category: Allergy & Immunology Authors: Music S Tags: vaccine Source Type: journals

SmallpoxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
— Comprehensive overview covers symptoms, causes, vaccine prevention of this devastating disease. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - August 14, 2009 Category: Consumer Health News Source Type: news

Pupils could be immunised against swine flu in schoolsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Every pupil in Britain could be immunised against swine flu in school under plans being considered by the Government. (Source: The Telegraph : Swine Flu A H1N1)
Source: The Telegraph : Swine Flu A H1N1 - August 7, 2009 Category: Infectious Diseases Tags: swine flu sir liam donaldson mass vaccination schools 1964 smallpox GPs bedrock Source Type: news

Rush to get national swine flu jabs readyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
• At least 15 million people in priority categories• Planning for bird flu in 2003 serves as blueprintGovernment officials are working urgently to put arrangements in place that could see all 60 million citizens rolling up a sleeve to receive the H1N1 vaccine when it becomes generally available – the first campaign on such a scale since 1964, when every Briton was vaccinated against smallpox.Although the media focus on the pandemic has diminished as the first wave of infection has begun to recede, officials at the Department of Health (DH) have been planning to try to ensure both that the inoculation campaign goes sm...
Source: Guardian Unlimited Science - August 6, 2009 Category: Science Authors: James Sturcke, Denis Campbell Tags: Swine flu Health & wellbeing World news Life and style Flu pandemic Society Health policy Politics Labour UK news guardian.co.uk Source Type: news

Laboratory-acquired vaccinia virus infection--Virginia, 2008.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes the subsequent investigations conducted by the Virginia Department of Health and CDC to identify the source of infection and any cases of contact transmission. Of the patient's 102 possible contacts, seven had underlying risk factors for developing serious vaccinia infection. Investigators found no evidence of contact transmission and, based on the results of molecular typing, further concluded that the patient had been exposed to a VACV strain that had contaminated the seed stock from the laboratory where the patient worked. This case underscores the importance of adherence to ACIP vaccination recomm...
Source: MMWR Morb Mortal Wkl... - July 30, 2009 Category: Epidemiology Tags: MMWR Morb Mortal Wkly Rep Source Type: journals

Evaluation of the efficacy of modified vaccinia Ankara (MVA)/IMVAMUNE((R)) against aerosolized rabbitpox virus in a rabbit model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study shows that IMVAMUNE((R)) can be a very effective vaccine against aerosolized RPXV. PMID: 19632316 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - July 22, 2009 Category: Allergy & Immunology Authors: Garza NL, Hatkin JM, Livingston V, Nichols DK, Chaplin PJ, Volkmann A, Fisher D, Nalca A Tags: vaccine Source Type: journals

Comparative evaluation of the immune response and protection engendered by LC16m8 and Dryvax smallpox vaccines in a mouse model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The immune response elicited by LC16m8, a candidate smallpox vaccine that was developed in Japan by cold selection during serial passage of the Lister vaccine virus in primary rabbit kidney cells, was compared to Dryvax in a mouse model. LC16m8 carries a mutation resulting in the truncation of the B5 protein, an important neutralizing target of the extracellular envelope (EV) form of vaccinia virus. LC16m8 elicited a broad-spectrum IgG response that neutralized both the EV and intracellular mature (MV) form of vaccinia virus, and provoked cell-mediated immune responses, including the activation of CD4(+) and CD8(+) cel...
Source: Clinical and Vaccine Immunology - July 14, 2009 Category: Allergy & Immunology Authors: Meseda CA, Mayer AE, Kumar A, Garcia AD, Campbell J, Listrani P, Manischewitz J, King LR, Golding H, Merchlinsky M, Weir JP Tags: Clin vaccine Immunol Source Type: journals

Oncolytic vaccinia viral therapy of squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results demonstrate significant efficacy by an attenuated vaccinia virus for infecting and lysing head and neck SCC both in vitro and in vivo, and support its continued investigation in future clinical trials. (Source: Molecular Cancer)
Source: Molecular Cancer - July 5, 2009 Category: Cancer & Oncology Authors: Zhenkun YuSen LiPeter BraderNanhai ChenYong YuQian ZhangAladar SzalayYuman FongRichard Wong Source Type: journals

Inhibition of S100A11 gene expression impairs keratinocyte response against vaccinia virus through downregulation of the IL-10 receptor 2 chainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Inhibition of S100A11 gene expression impairs the ability of keratinocytes to control VV replication via downregulation of IFN-λ receptor IL-10R2. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - July 5, 2009 Category: Allergy & Immunology Authors: Lianghua Bin, Michael D. Howell, Byung Eui Kim, Clifton F. Hall, Joanne E. Streib, Donald Y.M. Leung Tags: Atopic dermatitis and skin disease Source Type: journals

Eczema Patients Most At Risk For Dangerous Viral InfectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eczema patients at risk for serious viral infections have more severe disease, are more likely to be allergic to food and other allergens, and have a frequent history of staph infections, according to researchers. The findings could help identify people at risk for serious complications of smallpox vaccinations, and point to defects in the skin barrier and antimicrobial-protein production as possible causes for the increased susceptibility. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 29, 2009 Category: Science Source Type: news

Recent advances in tropical medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: There have been significant advances in both the classical and neglected tropical diseases, with Guinea worm looking set to be the next disease after smallpox to be eradicated. Aided by a combination of enhanced understanding of the biology of the pathogens, intensification of immunisation activities or mass drug administration, together with the development of synergies with control programmes for co-endemic tropical diseases, polio, lymphatic filariasis, trachoma and onchocerciasis all appear to be in global decline, with good prospects for eventual successful elimination. While the global incidence of new cases...
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene - June 25, 2009 Category: Tropical Medicine Authors: Anthony W. Solomon, Shevanthi Nayagam, Geoffrey Pasvol Tags: Reviews Source Type: journals

Study characterizes eczema patients most at risk for dangerous viral infectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(National Jewish Medical and Research Center) Eczema patients at risk for serious viral infections have more severe disease, are more likely to be allergic to food and other allergens, and have a frequent history of staph infections, according to researchers at National Jewish Health. The findings could help identify people at risk for serious complications of smallpox vaccinations, and point to defects in the skin barrier and antimicrobial-protein production as possible causes for the increased susceptibility. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 25, 2009 Category: Global & Universal Source Type: news

Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Threats of bioterrorism have renewed efforts to better understand poxvirus pathogenesis and to develop a safer vaccine against smallpox. Individuals with atopic dermatitis are excluded from smallpox vaccination because of their propensity to develop eczema vaccinatum, a disseminated vaccinia virus (VACV) infection. To study the underlying mechanism of the vulnerability of atopic dermatitis patients to VACV infection, we developed a mouse model of eczema vaccinatum. Virus infection of eczematous skin induced severe primary erosive skin lesions, but not in the skin of healthy mice. Eczematous mice exhibited lower natural kil...
Source: The Journal of Experimental Medicine - June 8, 2009 Category: Internal Medicine Authors: Kawakami, Y., Tomimori, Y., Yumoto, K., Hasegawa, S., Ando, T., Tagaya, Y., Crotty, S., Kawakami, T. Tags: Brief Definitive Reports Source Type: journals

Cardiac Complications after Smallpox Vaccination.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article describes a report of myopericarditis following smallpox immunization and provides a review of all cardiac complications associated with vaccination.Page: 615DOI: 10.1097/SMJ.0b013e31819fe55bAuthors: Mora, Luis F. MD; Khan, Akbar H. MD; Sperling, Laurence S. MD, FACC, FACP, FAHA (Source: Southern Medical Journal)
Source: Southern Medical Journal - June 7, 2009 Category: Journals (General) Tags: Abstract HTML PDF (186 K) Source Type: journals

The immunology of smallpox vaccines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In spite of the eradication of smallpox over 30 years ago; orthopox viruses such as smallpox and monkeypox remain serious public health threats both through the possibility of bioterrorism and the intentional release of smallpox and through natural outbreaks of emerging infectious diseases such as monkeypox. The eradication effort was largely made possible by the availability of an effective vaccine based on the immunologically cross-protective vaccinia virus. Although the concept of vaccination dates back to the late 1800s with Edward Jenner, it is only in the past decade that modern immunologic tools have been applie...
Source: Current Opinion in Immunology - May 31, 2009 Category: Allergy & Immunology Authors: Kennedy RB, Ovsyannikova IG, Jacobson RM, Poland GA Tags: Curr Opin Immunol Source Type: journals

Mystery Of Potentially Fatal Reaction To Smallpox Vaccine Unlocked By La Jolla InstituteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers from the La Jolla Institute for Allergy & Immunology have pinpointed the cellular defect that increases the likelihood, among eczema sufferers, of developing eczema vaccinatum, a severe and potentially fatal reaction to the smallpox vaccine. The research, conducted in mouse models, was funded under a special research network created by the National Institutes of Health in 2004. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 26, 2009 Category: Consumer Health News Tags: Eczema / Psoriasis Source Type: news

Research developing smallpox vaccine for eczema sufferersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers from the La Jolla Institute for Allergy & Immunology have pinpointed the cellular defect that increases the likelihood, among eczema sufferers, of developing eczema vaccinatum, a severe and potentially fatal reaction to the smallpox vaccine. The research, conducted in mouse models, was funded under a special research network created by the National Institutes of Health in 2004. (Source: Huliq Health News)
Source: Huliq Health News - May 25, 2009 Category: Consumer Health News Authors: harminka Tags: Health eczema smallpox vaccine Source Type: news

La Jolla Institute unlocks mystery of potentially fatal reaction to smallpox vaccineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(La Jolla Institute for Allergy and Immunology) Researchers from the La Jolla Institute for Allergy & Immunology have pinpointed the cellular defect that increases the likelihood, among eczema sufferers, of developing eczema vaccinatum, a severe and potentially fatal reaction to the smallpox vaccine. The research, conducted in mouse models, was funded under a special research network created by the National Institutes of Health in 2004. The network is working toward the development of a new smallpox vaccine that could be administered to eczema sufferers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 25, 2009 Category: Global & Universal Source Type: news

Progressive vaccinia in a military smallpox vaccinee - United States, 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report summarizes the patient's protracted clinical course and the military and civilian interagency governmental, academic, and industry public health contributions to his complex medical management. The quantities of investigational and licensed therapeutics and diagnostics used were greater than anticipated based on existing smallpox preparedness plans. To support future public health needs adequately, the estimated national supply of therapeutics and diagnostic resources required to care for smallpox vaccine adverse events should be reevaluated. PMID: 19478722 [PubMed - indexed for MEDLINE] (Source: MMWR Morb Mortal Wkl...)
Source: MMWR Morb Mortal Wkl... - May 21, 2009 Category: Epidemiology Tags: MMWR Morb Mortal Wkly Rep Source Type: journals

Scientists Discover How Smallpox May Derail Human Immune SystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
University of Florida researchers have learned more about how smallpox conducts its deadly business - discoveries that may reveal as much about the human immune system as they do about one of the world's most feared pathogens. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 12, 2009 Category: Consumer Health News Tags: Immune System / vaccines Source Type: news

Smallpox revaccination of 21000 first responders in Israel: lessons learnedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The campaign achieved all its basic goals and provided useful lessons for any mass-vaccination programs that might be necessary in the future. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 22, 2009 Category: Infectious Diseases Authors: Emilia Anis, Alex Leventhal, Paul E. Slater, Eilat Shinar, Vered Yahalom, Zahava Smetana, Ruth Zach, Shmuel Reznikovich, Ella Mendelson, Yehuda Danon, Boaz Lev Tags: Original Reports Source Type: journals

Smallpox vaccine: Regional folliculitis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - April 18, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Smallpox vaccine: Regional folliculitis: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 31 (Source: Reactions Weekly)
Source: Reactions Weekly - April 18, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

New Smallpox Vaccine Immunogenic and SafeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The third-generation smallpox vaccine LC16m8 was found to be as immunogenic as existing smallpox vaccines but appeared to be safer in a study of more than 3,000 Japanese adults. (Source: Internal Medicine News)
Source: Internal Medicine News - April 15, 2009 Category: Internal Medicine Authors: MARY ANN MOON Tags: Infectious Diseases Source Type: journals