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Cancers, Vol. 15, Pages 4689: Estrogen Receptor Signaling in Breast Cancer
rzej Stepulak
Estrogen receptor (ER) signaling is a critical regulator of cell proliferation, differentiation, and survival in breast cancer (BC) and other hormone-sensitive cancers. In this review, we explore the mechanism of ER-dependent downstream signaling in BC and the role of estrogens as growth factors necessary for cancer invasion and dissemination. The significance of the clinical implications of ER signaling in BC, including the potential of endocrine therapies that target estrogens’ synthesis and ER-dependent signal transmission, such as aromatase inhibitors or selective estrogen receptor modul...
Source: Cancers - September 23, 2023 Category: Cancer & Oncology Authors: Paulina Miziak Marzena Baran Ewa B łaszczak Alicja Przybyszewska-Podstawka Joanna Ka łafut Jolanta Smok-Kalwat Magdalena Dmoszy ńska-Graniczka Micha ł Kiełbus Andrzej Stepulak Tags: Review Source Type: research
Viruses, Vol. 15, Pages 1982: Molecular Imaging of ACE2 Expression in Infectious Disease and Cancer
J. Thorek
Angiotensin-converting enzyme 2 (ACE2) is a cell-surface receptor that plays a critical role in the pathogenesis of SARS-CoV-2 infection. Through the use of ligands engineered for the receptor, ACE2 imaging has emerged as a valuable tool for preclinical and clinical research. These can be used to visualize the expression and distribution of ACE2 in tissues and cells. A variety of techniques including optical, magnetic resonance, and nuclear medicine contrast agents have been developed and employed in the preclinical setting. Positron-emitting radiotracers for highly sensitive and quantitative tomography have ...
Source: Viruses - September 23, 2023 Category: Virology Authors: Zhiyao Li Abbie Hasson Lasya Daggumati Hanwen Zhang Daniel L. J. Thorek Tags: Review Source Type: research
Viruses, Vol. 15, Pages 1983: Exploring the Comprehensive Kozak Sequence Landscape for AAV Production in Sf9 System
hin
The widespread successful use of recombinant Adeno-associated virus (rAAV) in gene therapy has driven the demand for scale-up manufacturing methods of vectors with optimized yield and transduction efficiency. The Baculovirus/Sf9 system is a promising platform for high yield production; however, a major drawback to using an invertebrate cell line compared to a mammalian system is a generally altered AAV capsid stoichiometry resulting in lower biological potency. Here, we introduce a term of the structural and biological “fitness” of an AAV capsid as a function of two interdependent parame...
Source: Viruses - September 23, 2023 Category: Virology Authors: Oleksandr Kondratov Sergei Zolotukhin Tags: Article Source Type: research
Good Oral Health Linked to Improved Survival in Head & Neck Cancer
FRIDAY, Sept. 22, 2023 -- For patients with head and neck squamous cell carcinoma, good oral health is associated with improved survival, according to a study published online Sept. 19 in the Journal of the National Cancer Institute.
Jason Tasoulas,...
Source: Drugs.com - Pharma News - September 22, 2023 Category: Pharmaceuticals Source Type: news
Mesenchymal Stem Cell –Originated Exosomal Lnc A2M-AS1 Alleviates Hypoxia/Reperfusion-Induced Apoptosis and Oxidative Stress in Cardiomyocytes
ConclusionLnc A2M-AS1 delivery via MSC-derived exosomes ameliorated H/R-induced cardiomyocyte apoptosis and oxidative stress via regulating miR-556-5p/XIAP, opening a new window into the pathogenesis of myocardial I/R injury.
Source: Cardiovascular Drugs and Therapy - September 22, 2023 Category: Cardiology Source Type: research
A Call for Matching Donors for the LEV Foundation " Robust Mouse Rejuvenation 2 " Fundraiser
The Longevity Escape Velocity (LEV) Foundation was founded by Aubrey de Grey to address an important missing aspect of the ongoing work to produce treatments that target the underlying mechanisms of aging. While the research and development community has made sizable strides in the past decade, and the first rejuvenation therapies now exist in at least prototype form, it remains the case that next to no-one is conducting combination studies that use two or more of these interventions. When considering therapies that can repair forms of the cell and tissue damage that cause aging, it seems plausible that two different thera...
Source: Fight Aging! - September 22, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Patients With Rheumatism Have Premature Immune System Aging Patients With Rheumatism Have Premature Immune System Aging
Researchers have studied how the T-cell aging process translates into metabolic reprogramming of the T-cells in patients with rheumatoid arthritis.Medscape Medical News
Source: Medscape Allergy Headlines - September 22, 2023 Category: Allergy & Immunology Tags: Rheumatology News Source Type: news
PET/MR Imaging in Head and Neck Cancer
Head and neck squamous cell carcinoma (HNSCC) can either be examined with hybrid PET/MR imaging systems or sequentially, using PET/CT and MR imaging. Regardless of the acquisition technique, the superiority of MR imaging compared to CT lies in its potential to interrogate tumor and surrounding tissues with different sequences, including perfusion and diffusion. For this reason, PET/MR imaging is preferable for the detection and assessment of locoregional residual/recurrent HNSCC after therapy. In addition, MR imaging interpretation is facilitated when combined with PET. Nevertheless, distant metastases and distant second p...
Source: Magnetic Resonance Imaging Clinics of North America - September 22, 2023 Category: Radiology Authors: Minerva Becker, Claudio de Vito, Nicolas Dulguerov, Habib Zaidi Source Type: research
WellSky Acquires Experience Care to Enhance Long-Term Care Providers ’ Ability to Operate Efficiently, Advance Resident Care
Together, the Healthcare Technology Companies will Continue to Innovate and Strengthen Solutions that Position Organizations to Succeed Against Industry Challenges and Thrive in Value-Based Care
WellSky, a leading health and community care technology company, announced today that it has acquired Experience Care, an innovative technology company offering a suite of software solutions for post-acute and long-term care providers. With the addition of Experience Care, WellSky expands its commitment and investment in the long-term care market.
Experience Care has a proven track record with its leading electronic health record ...
Source: EMR and HIPAA - September 22, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Bill Miller Experience Care Gina Barrett Health IT Acquisitions Healthcare Growth Partners Healthcare M&A WellSky Source Type: blogs
Saving lives, preventing health risks and restoring health care services in the aftermath of ...
Tripoli, Libya, 22 September 2023 – In the wake of catastrophic floods that had a devastating impact on Libya's east coast, the World Health Organization (WHO) is taking swift action to assist affected communities. WHO is supporting urgent efforts to restore access to health care and control the spread of infectious diseases, especially among the tens of thousands of people who have been displaced and are now living in shelters.
“The magnitude of this catastrophe is staggering,” said Dr Ahmed Zouiten, WHO Representative in Libya. “The need for swift, unified action cannot be overstated. We are collaborating closel...
Source: WHO EMRO News - September 22, 2023 Category: Middle East Health Source Type: news
The role of miR-139-5p in radioiodine-resistant thyroid cancer
ConclusionsOur study provides evidence of miR-139-5p involvement in iodine uptake metabolism and suggests its possible role as a therapeutic target in restoring iodine uptake in RAI-refractory DTC.
Source: Journal of Endocrinological Investigation - September 22, 2023 Category: Endocrinology Source Type: research
Ceruloplasmin regulating fibrosis in orbital fibroblasts provides a novel therapeutic target for Graves ’ orbitopathy
ConclusionCP was downregulated in GO and suppressed the expression of fibrosis-associated proteins in both GO and normal OFs. CP might serve as a promising therapeutic agent in the treatment regimens for GO.
Source: Journal of Endocrinological Investigation - September 22, 2023 Category: Endocrinology Source Type: research
Skin and gut microbial associations with squamous cell carcinoma in solid organ transplant recipients
AbstractSolid organ transplant recipients (SOTRs) are burdened with a significantly higher risk of squamous cell carcinoma (SCC) compared to the general population. Accumulating evidence suggests the potential influence of microbial dysbiosis on transplant outcomes. Based on these observations, we sought to identify differences in the cutaneous and gut microbiomes of SOTRs with and without a history of SCC. This case –control study collected and analyzed non-lesional skin and fecal samples of 20 SOTRs > 18 years old with either ≥ 4 diagnoses of SCC since most recent transplant (n = 10) or 0 diagnoses o...
Source: Archives of Dermatological Research - September 22, 2023 Category: Dermatology Source Type: research
Posaconazole and risk of cutaneous squamous cell carcinoma after lung transplantation: a single institution, retrospective cohort study
Source: Archives of Dermatological Research - September 22, 2023 Category: Dermatology Source Type: research
The Adaptation-Maladaptation Framework of Aging
While a great deal is known about the ways in which old tissues differ from young tissues, there remains considerable room to theorize on how exactly aging is caused and progresses. Which manifestations are causative, and which downstream consequences, which mechanisms are important, which are side-effects or diversions. Theories of aging abound, alongside frameworks intended to steer thinking about aging. We stand in the opening years of a new era of medicine, in which the first rejuvenation therapies exist or are under development, senolytics that can clear senescent cells, alongside reprogramming strategies and potentia...
Source: Fight Aging! - September 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
