Fear extinction is impaired in aged rats
AbstractNormal aging is accompanied by broad loss of cognitive function in humans and rodents, including declines in cognitive flexibility. In extinction, a conditional stimulus (CS) that was previously paired with a footshock is presented alone. This procedure reliably reduces conditional freezing behavior in young adult rats. Here, we aimed to investigate how normal aging affects extinction learning. Using young (3 months) and aged (20 months) male and female Long Evans rats, we compared extinction (using 20 CS-alone presentations) to a no extinction control (equal exposure to the conditioning chamber without CS prese...
Source: AGE - April 12, 2024 Category: Geriatrics Source Type: research
Molecular cross-talk between long COVID-19 and Alzheimer ’s disease
AbstractThe long COVID (coronavirus disease), a multisystemic condition following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, is one of the widespread problems. Some of its symptoms affect the nervous system and resemble symptoms of Alzheimer ’s disease (AD)—a neurodegenerative condition caused by the accumulation of amyloid beta and hyperphosphorylation of tau proteins. Multiple studies have found dependence between these two conditions. Patients with Alzheimer’s disease have a greater risk of SARS-CoV-2 infection due to increased levels of angiotensin-converting enzyme 2 (ACE2), and the ...
Source: AGE - April 12, 2024 Category: Geriatrics Source Type: research
Senolytic treatment fails to improve ovarian reserve or fertility in female mice
AbstractSenescent cell number increases with age in different tissues, leading to greater senescent cell load, proinflammatory stress, and tissue dysfunction. In the current study, we tested the efficacy of senolytic drugs to reduce ovarian senescence and improve fertility in reproductive age female mice. In the first experiment, 1-month-old C57BL/6 female mice were treated every other week with D + Q (n = 24) or placebo (n = 24). At 3 and 6 months of age, female mice were mated with untreated males to evaluate pregnancy rate and litter size. In the second experiment, 6-month-old C57BL/6 female mice were trea...
Source: AGE - April 12, 2024 Category: Geriatrics Source Type: research
Performance of digital technologies in assessing fall risks among older adults with cognitive impairment: a systematic review
AbstractOlder adults with cognitive impairment (CI) are twice as likely to fall compared to the general older adult population. Traditional fall risk assessments may not be suitable for older adults with CI due to their reliance on attention and recall. Hence, there is an interest in using objective technology-based fall risk assessment tools to assess falls within this population. This systematic review aims to evaluate the features and performance of technology-based fall risk assessment tools for older adults with CI. A systematic search was conducted across several databases such as PubMed and IEEE Xplore, resulting in...
Source: AGE - April 12, 2024 Category: Geriatrics Source Type: research
Correction to: Ultra ‑processed food consumption and nutritional frailty in older age
(Source: AGE)
Source: AGE - April 12, 2024 Category: Geriatrics Source Type: research
Correction to: The influence of APOE status on rate of cognitive decline
(Source: AGE)
Source: AGE - April 12, 2024 Category: Geriatrics Source Type: research
Sex differences in interacting genetic and functional connectivity biomarkers in Alzheimer ’s disease
AbstractAs of 2023, it is estimated that 6.7 million individuals in the United States live with Alzheimer ’s disease (AD). Prior research indicates that AD disproportionality affects females; females have a greater incidence rate, perform worse on a variety of neuropsychological tasks, and have greater total brain atrophy. Recent research shows that hippocampal functional connectivity differs by sex a nd may be related to the observed sex differences in AD, and apolipoprotein E (ApoE) ε4 carriers have reduced hippocampal functional connectivity. The purpose of this study was to determine if the ApoE genotype plays a rol...
Source: AGE - April 10, 2024 Category: Geriatrics Source Type: research
Spousal bereavement and its effects on later life physical and cognitive capability: the Troms ø study
AbstractSpousal bereavement is associated with health declines and increased mortality risk, but its specific impact on physical and cognitive capabilities is less studied. A historical cohort study design was applied including married Troms ø study participants (N=5739) aged 50 –70 years with baseline self-reported overall health and health-related factors and measured capability (grip strength, finger tapping, digit symbol coding, and short-term recall) at follow-up. Participants had data from Tromsø4 (1994–1995) and Tromsø5 (2001), or Tromsø6 (2007–2008) and Tro msø7 (2015–2016). Propensity score matching, ...
Source: AGE - April 9, 2024 Category: Geriatrics Source Type: research
The association between blood biological age at rehabilitation admission and physical activity during rehabilitation in geriatric inpatients: RESORT
In conclusion, high er biological age was associated with higher levels of SB and trended towards lower PA. Incorporating blood biological age could facilitate resource allocation and the development of more tailored rehabilitation plans. (Source: AGE)
Source: AGE - April 9, 2024 Category: Geriatrics Source Type: research
Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans
AbstractReduced insulin/IGF-1 signalling (rIIS) improves survival across diverse taxa and there is a growing interest in its role in regulating immune function. Whilst rIIS can improve anti-bacterial resistance, the consequences for anti-viral immunity are yet to be systematically examined. Here, we show that rIIS in adultCaenorhabditis elegans increases the expression of key genes in two different anti-viral immunity pathways, whilst reducing viral load in old age, increasing survival and reducing rate-of-senescence under infection by naturally occurring positive-sense single-stranded RNA Orsay virus. We found that bothdr...
Source: AGE - April 8, 2024 Category: Geriatrics Source Type: research
Yoga-based lifestyle intervention for healthy ageing in older adults: a two-armed, waitlist randomized controlled trial with multiple primary outcomes
AbstractYoga-based clinical research has shown considerable promise in varied ageing-related health outcomes in older adults. However, robust frameworks have yet to be used in intervention research to endorse yoga as a healthy ageing intervention to test the multidimensional construct of healthy ageing. This was an assessor-masked, randomized controlled trial conducted among 258 sedentary, community-dwelling older adults aged 60 –80 years, randomly allocated to 26-week yoga-based intervention (YBI) (n = 132) or waitlist control (WLC) (n = 126). The effectiveness of YBI was assessed through two separate global st...
Source: AGE - April 7, 2024 Category: Geriatrics Source Type: research
Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging
In this study, we investigated two molecules: mycothiazole (MTZ) - from the marine spongeC. mycofijiensis and its more stable semisynthetic analog 8-O-acetylmycothiazole (8-OAc) as potent and selective chemical probes based on their high efficiency to inhibit ETC complex I function. Similar to rotenone (Rote), MTZ, a newly employed ETC complex I inhibitor, exhibited higher cytotoxicity against cancer cell lines compared to certain non-cancer cell lines. Interestingly, 8-OAc demonstrated greater selectivity for cancer cells when compared to both MTZ and Rote, which has promising potential for anticancer therapeutic developm...
Source: AGE - April 3, 2024 Category: Geriatrics Source Type: research
The behavioural effect of short-term cognitive and physical intervention therapies in old dogs
We examined the impact of three-month-long intervention therapies (cognitive, physical, combined) on the cognitive performance and behaviour of old, healthy dogs (N = 72; aged 7.68–14.54 years) using a 12-subtest behavioural test battery. We did not find the combined intervention group outperforming either the cognitive-only or physical-only therapy groups. Physical interventions, either alone or in combination, improved dogs' behavioural flexibility an d social behaviour. Cognitive interventions, either alone or in combination, increased neophilia. Furthermore, all intervention therapies made dogs more engaged wit...
Source: AGE - April 3, 2024 Category: Geriatrics Source Type: research
DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson ’s disease
In conclusion, these studies support further evaluation of the repurposing of clinically approved gliptins as a treatment strategy for PD. (Source: AGE)
Source: AGE - April 2, 2024 Category: Geriatrics Source Type: research
Therapeutic efficacies of mitochondria-targeted esculetin and metformin in the improvement of age-associated atherosclerosis via regulating AMPK activation
AbstractAtherosclerosis, in general, is an age-associated cardiovascular disease wherein a progressive decline in mitochondrial function due to aging majorly contributes to the disease development. Mitochondria-derived ROS due to dysregulated endothelial cell function accentuates the progression of atherosclerotic plaque formation. To circumvent this, mitochondrially targeted antioxidants are emerging as potential candidates to combat metabolic abnormalities. Recently, we synthesized an alkyl TPP+ tagged esculetin (Mito-Esc), and in the current study, we investigated the therapeutic efficacies of Mito-Esc and metformin, a ...
Source: AGE - March 5, 2024 Category: Geriatrics Source Type: research
