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QUINAPRIL HYDROCHLORIDEtablet, Film Coated [Greenstone LLC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 19, 2009 Category: Drugs & Pharmacology Source Type: organizations

ACCUPRIL (Quinapril Hydrochloride) Tablet, Film Coated [Parke-Davis Div Of Pfizer Inc]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 19, 2009 Category: Drugs & Pharmacology Source Type: organizations

ACCURETIC (Quinapril Hydrochloride And Hydrochlorothiazide) Tablet, Film Coated [Parke-Davis Div Of Pfizer Inc]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 19, 2009 Category: Drugs & Pharmacology Source Type: organizations

QUINAPRIL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDEtablet, Film Coated [Greenstone LLC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 19, 2009 Category: Drugs & Pharmacology Source Type: organizations

Stabilization of quinapril by incorporating hydrogen bonding interactionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Roy B N, Singh G P, Godbole H M, Nehate S PIndian Journal of Pharmaceutical Sciences 2009 71(4):395-405In the present study stability of various known solvates of quinapril hydrochloride has been compared with nitromethane solvate. Nitromethane solvate was found to be more stable compared to other known solvates. Single crystal X-ray diffraction analysis of quinapril nitromethane solvate shows intermolecular hydrogen bonding between quinapril molecule and nitromethane. Stabilization of quinapril by forming strong hydrogen bonding network as in case of co-crystals was further studied by forming co-crystal with tris(hydroxym...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Roy B N, Singh G P, Godbole H M, Nehate S P Source Type: journals

The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions/interpretation This study demonstrates that ETA blockade with avosentan may provide an alternate therapeutic strategy for the treatment of diabetic micro- and macrovascular complications. Content Type Journal ArticleCategory ArticleDOI 10.1007/s00125-009-1540-3Authors A. M. D. Watson, Baker IDI Heart and Diabetes Institute PO Box 6492 St Kilda Road Central Melbourne 8008 VIC AustraliaJ. Li, Baker IDI Heart and Diabetes Institute PO Box 6492 St Kilda Road Central Melbourne 8008 VIC AustraliaC. Schumacher, Novartis Pharma Basel SwitzerlandM. de Gasparo, MG Consulting Rossemaison Switzerland...
Source: Diabetologia - October 27, 2009 Category: Endocrinology Tags: Diabetologia Source Type: journals

Accupril (Quinapril Hydrochloride) - updated on RxListEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Accupril (Quinapril Hydrochloride) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - October 9, 2009 Category: Drugs & Pharmacology Source Type: consumer

Ion pair-HPLC method for the simultaneous estimation of quinapril and hydrochlorothiazide in tabletsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gandhimathi M, Ravi T KIndian Journal of Pharmaceutical Sciences 2009 71(3):311-313A simple, precise and rapid HPLC method has been developed and validated for the estimation of quinapril and hydrochlorothiazide simultaneously in combined dosage form. The mobile phase used was a mixture of 0.1% v/v triethylamine (pH 3.5), containing 1 mM of hexane sulphonic acid: acetonitrile (30:70% v/v). The detection of quinapril and hydrochlorothiazide was carried out on photo diode array detector at 220 nm. Results of the analysis were validated statistically and by recovery studies. The proposed method can be successful...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Gandhimathi M, Ravi T K Source Type: journals

QUINAPRIL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDEtablet, Film Coated [Mylan Pharmaceuticals Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 24, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 24, 2009 Category: Drugs & Pharmacology Source Type: organizations

QUINAPRIL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDEtablet, Film Coated [Greenstone LLC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Jul 2, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - July 2, 2009 Category: Drugs & Pharmacology Source Type: organizations

Sun Pharma USFDA nod for anti hypertensive drugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sun Pharmaceutical Industries said it has got approval for its Abbreviated New Drug Application for generic version of Quinapril Hydrochloride tablets used in treatment of hypertension and congested heart failure. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - June 19, 2009 Category: Pharmaceuticals Source Type: news

Sex-dependent impairment of cardiac action potential conduction in type 1 diabetic ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the slowing of cardiac impulse propagation in type 1 diabetes is smaller in female rats, partly due to the presence of female sex hormones. This difference is (partly) mediated by sex differences in activation of the cardiac renin-angiotensin system. (Source: AJP: Heart and Circulatory Physiology)
Source: AJP: Heart and Circulatory Physiology - May 1, 2009 Category: Cardiology Authors: Shimoni, Y., Emmett, T., Schmidt, R., Nygren, A., Kargacin, G. Tags: ARTICLES Source Type: journals

QUINAPRIL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDEtablet, Film Coated [Ranbaxy Pharmaceuticals Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Apr 2, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - April 2, 2009 Category: Drugs & Pharmacology Source Type: organizations

Ranbaxy Secures Usfda Approval For Quinapril+Hctz TabletsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ranbaxy Laboratories Limited (Ranbaxy), announced that the company has received an approval from the U.S. Food and Drug Administration (USFDA) for its Abbreviated New Drug Application (ANDA) for Quinapril Hydrochloride & Hydrochlorothiazide (Quinapril + HCTZ) Tablets, 10mg/12.5mg, 20mg/12.5mg and 20mg/25mg. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 19, 2009 Category: Consumer Health News Tags: Hypertension Source Type: news

Gender-Dependent Impairment of Cardiac Action Potential Conduction in Type 1 Diabetic Rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the slowing of cardiac impulse propagation in type 1 diabetes is smaller in female rats, partly due to the presence of female sex hormones. This difference is (partly) mediated by gender differences in activation of the cardiac renin-angiotensin system. Key words: Diabetes, gender, impulse propagation, gap junction. PMID: 19286947 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 13, 2009 Category: Physiology Authors: Shimoni Y, Emmett T, Schmidt R, Nygren A, Kargacin GJ Tags: Am J Physiol Heart Circ Physiol Source Type: journals

Validated HPTLC method for simultaneous determination of quinapril hydrochloride and hydrochlorothiazide in a tablet dosage formEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bhavar Girija B, Chatpalliwar V A, Patil D D, Surana S JIndian Journal of Pharmaceutical Sciences 2008 70(4):529-531Quinapril hydrochloride and hydrochlorothiazide were simultaneously determined by HPTLC in pharmaceutical formulations. The drugs were separated on silica gel 60 F<sub> 254</sub> plates using suitable combination of solvents as mobile phase. The validation parameters, tested in accordance with the requirements of ICH guidelines, prove the suitability of methods. (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - December 20, 2008 Category: Drugs & Pharmacology Authors: Bhavar Girija B, Chatpalliwar V A, Patil D D, Surana S J Source Type: journals

Determination of quinapril and quinaprilat in human plasma by ultraperformance liquid chromatography-electrospray ionization mass spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel, specific and sensitive ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed for the simultaneous determination of quinapril and its active metabolite quinaprilat in human plasma. The method involves a simple, one-step extraction procedure coupled with an Acquity UPLCtrade mark BEH C(18 )column (100 x 2.1 mm, i.d., 1.7 microm) with isocratic elution at a flow-rate of 0.2 mL/min and lisinopril as the internal standard. Detection was performed on a triple-quadrupole tandem mass spectrometer in multiple reaction monitoring mode via electrospray ionization. Using 250 mi...
Source: Biomedical Chromatography : BMC - November 17, 2008 Category: Biomedical Science Authors: Dasandi B, Shah S, Tags: Biomed Chromatogr Source Type: journals

Amlodipine a safe add-on to quinapril, losartan in hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Inpharma)
Source: Inpharma - October 13, 2008 Category: Drugs & Pharmacology Tags: Research article Source Type: journals

Amlodipine a safe add-on to quinapril, losartan in hypertension.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 14 (Source: Inpharma Weekly)
Source: Inpharma Weekly - October 11, 2008 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Quinaretic(Quinapril Hydrochloride And Hydrochlorothiazide) Tablet [Actavis Totowa LLC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Jul 28, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - July 28, 2008 Category: Drugs & Pharmacology Source Type: organizations

Quinapril Hydrochloride(Quinapril Hydrochloride) Tablet, Film Coated [Greenstone LLC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Jul 25, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - July 25, 2008 Category: Drugs & Pharmacology Source Type: organizations

Quinapril Improves Endothelial Function in Postmenopausal Hypertensive PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Kidney Blood Press Res 2008;31:226-233 (DOI:10.1159/000141927) (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 27, 2008 Category: Urology & Nephrology Source Type: journals

Ranbaxy and Pfizer Settle Lipitor Litigation WorldwideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ranbaxy Will Market Generic Atorvastatin in the U.S. With 180 Days Exclusivity From Nov. 30, 2011 Agreement Also Resolves Caduet, Accupril Litigation in the US GURGAON, Harayana, India and PRINCETON, N.J., June 18 (HSMN NewsFeed) -- Ranbaxy Laborat... Biopharmaceuticals, Generics, Litigation, LicensingRanbaxy Laboratories, Pfizer, Lipitor (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - June 18, 2008 Category: Pharmaceuticals Source Type: news

Potential advantages of cell administration on the inflammatory response compared to standard ACE inhibitor treatment in experimental myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: After myocardial infarction, both BMMNCs and ACE-I reduce the pattern of pro-Ck response, probably contributing to prevent the deterioration of LV function observed in UT rats. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 12, 2008 Category: Research Authors: Michele M Ciulla, Elisa Montelatici, Stefano Ferrero, Paola Braidotti, Roberta Paliotti, Giuseppe Annoni, Elisa De Camilli, Giuseppe Busca, Luisa Chiappa, Paolo Rebulla, Fabio Magrini and Lorenza Lazzari Source Type: journals

Effect of different angiotensin-converting-enzyme inhibitors on mortality among elderly patients with congestive heart failure.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BACKGROUND: Existing clinical trial data do not address whether all angiotensin-converting-enzyme (ACE) inhibitors are similarly beneficial in improving survival and reducing the rate of readmission among patients with congestive heart failure. We sought to answer this question using administrative databases from Canada's 3 most populous provinces. METHODS: Using linked hospital discharge and prescription claims databases in Quebec, Ontario and British Columbia, we identified all patients 65 years or older who were admitted to hospital because of congestive heart failure between Jan. 1, 1998, and Mar. 31, 2002, and who...
Source: cmaj - May 6, 2008 Category: Journals (General) Authors: Pilote L, Abrahamowicz M, Eisenberg M, Humphries K, Behlouli H, Tu JV Tags: CMAJ Source Type: journals

Lack of efficacy of quinapril on vascular damage in limited cutaneous systemic sclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gliddon et al. conducted a randomized, double-blind, multicenter, placebo-controlled study to evaluate the efficacy of the angiotensin-converting enzyme inhibitor quinapril for the management of vascular damage in systemic sclerosis (SSc). The trial comprised 213 patients with limited cutaneous SSc or Raynaud's phenomenon (mean age 54 years, 182 females) who were randomly assigned to receive 80 mg/day, or the maximum tolerated dose, of quinapril (n = 105) or placebo (n = 108) for 2-3 years. Patients were assessed every 3 months. The number of new ischemic digital ulcers was recorded as the primary end point, while the ...
Source: Nature Clinical Practice. Rheumatology. - May 6, 2008 Category: Rheumatology Authors: Guiducci S, Cerinic MM Tags: Nat Clin Pract Rheumatol Source Type: journals

Quinapril Hydrochloride(Quinapril Hydrochloride) Tablet, Film Coated [GENPHARM ULC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Apr 25, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - April 26, 2008 Category: Drugs & Pharmacology Source Type: organizations

Quinapril(Quinapril Hydrochloride) Tablet, Film Coated [Actavis Totowa LLC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Mar 25, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - March 25, 2008 Category: Drugs & Pharmacology Source Type: organizations

Impact of previous percutaneous transluminal coronary angioplasty and/or stenting revascularization on outcomes after surgical revascularization: insights from the imagine studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Patients with left ventricular ejection fraction ≥40% having a history of PCI prior to surgery had a worse outcome post-CABG than those with no prior PCI. Further studies are needed to investigate whether these results apply for drug eluting stents. (Source: European Heart Journal)
Source: European Heart Journal - March 1, 2008 Category: Cardiology Authors: Chocron, S., Baillot, R., Rouleau, J. L., Warnica, W. J., Block, P., Johnstone, D., Myers, M. G., Calciu, C. D., Nozza, A., Martineau, P., van Gilst, W. H., for the IMAGINE Investigators Tags: Cardiovascular surgery Source Type: journals

Angiotensin converting enzyme inhibition enhances collateral artery remodeling in rats with femoral artery occlusion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Evidence from experimental animal studies indicate that ACE inhibition expands collateral blood flow both in ischemic hearts and peripheral limbs. The present study evaluates whether ACE inhibitor induces collateral blood flow expansion and change of angiogenic gene expression profile in collateral arteries during remodeling. Male Sprague-Dawley rats, weighing 350 g were treated with vehicle (control) or quinapril (ACE inhibitor) at either low dose (3.0 mg/kg) or high dose (18 mg/kg) for 1, 3, 7, 14 days (gene expression) or 16 days (blood flow). All rats received bilateral occlusions of the femoral arteries. Collatera...
Source: The American Journal of the Medical Sciences - March 1, 2008 Category: Journals (General) Authors: Ren J, Li H, Prior BM, Yang HT Tags: Am J Med Sci Source Type: journals

Quinapril Hydrochloride(Quinapril Hydrochloride) Tablet, Film Coated [Mylan Pharmaceuticals Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Feb 15, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 15, 2008 Category: Drugs & Pharmacology Source Type: organizations

Comparison of Selective AT1-Receptor Blockade Versus ACE Inhibition for Restenosis Prophylaxis in Patients With Peripheral Occlusive Arterial Disease After Stent Angioplasty: A Randomized, Controlled, Proof-of-Concept StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study revealed significant benefit of a pharmacological restenosis regimen using the AT1-receptor antagonist candesartan in patients with severe atherosclerosis after superficial femoral artery stenting compared with treatment with the ACE inhibitor quinapril. Further prospective studies in patients are required to confirm these results. (Source: Angiology)
Source: Angiology - January 23, 2008 Category: Cardiology Authors: Schindler, C., Mueller, A., Bramlage, P., Boecking, W., Kirch, W., Schweizer, J. Tags: Article Source Type: journals

Early initiation of ACEIs in low-risk patients after coronary artery bypass surgery of no benefit?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
According to research published early online in Circulation, routine early initiation of angiotensin-converting enzyme inhibitor (ACEI) therapy does not appear to improve clinical outcome up to 3 years after coronary artery bypass surgery (CABG), but does increase the incidence of adverse events, particularly after CABG. The Ischaemia Management with Accupril post-bypass Graft via Inhibition of the coNverting Enzyme (IMAGINE) trial investigated whether early initiation (</= 7 days) of an ACEI after CABG reduced cardiovascular events in stable patients with left ventricular ejection fraction >/= 40%. The double-blind...
Source: NeLM Headline News - December 12, 2007 Category: Drugs & Pharmacology Source Type: organizations

Quinapril Fails to Prevent Vascular Damage in SclerodermaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The long-acting angiotensin-converting enzyme (ACE) inhibitor quinapril does not appear to prevent upper limb digital ulcers or other vascular manifestations in patients with limited cutaneous systemic sclerosis (lcSSc), according to UK researchers. Reuters Health Information (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - December 10, 2007 Category: Dermatology Tags: Rheumatology Source Type: info

Effects of Angiotensin-Converting Enzyme Inhibition in Low-Risk Patients Early After Coronary Artery Bypass Surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions-In patients at low risk of cardiovascular events after CABG, routine early initiation of angiotensin-converting enzyme inhibitor therapy does not appear to improve clinical outcome up to 3 years after CABG; however, it increases the incidence of adverse events, particularly early after CABG. Thus, early after CABG, initiation of angiotensin-converting enzyme inhibitor therapy should be individualized and continually reassessed over time according to risk. PMID: 18071079 [PubMed - as supplied by publisher] (Source: Circulation)
Source: Circulation - December 10, 2007 Category: Cardiology Authors: Rouleau JL, Warnica WJ, Baillot R, Block PJ, Chocron S, Johnstone D, Myers MG, Calciu CD, Dalle-Ave S, Martineau P, Mormont C, van Gilst WH, Tags: Circulation Source Type: journals

Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiogensin-converting enzyme inhibitionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acute physiological hyperinsulinemia increases skeletal muscle capillary blood volume (CBV), presumably to augment glucose and insulin delivery. We hypothesized that insulin-mediated changes in CBV are impaired in type 2 diabetes mellitus (DM) and are improved by angiotensin-converting enzyme inhibition (ACE-I). Zucker obese diabetic rats (ZDF, n = 18) and control rats (n = 9) were studied at 20 wk of age. One-half of the ZDF rats were treated with quinapril (ZDF-Q) for 15 wk prior to study. CBV and capillary flow in hindlimb skeletal muscle were measured by contrast-enhanced ultrasound (CEU) at baseline and at 30 and 120 ...
Source: AJP: Endocrinology and Metabolism - December 7, 2007 Category: Endocrinology Authors: Clerk, L. H., Vincent, M. A., Barrett, E. J., Lankford, M. F., Lindner, J. R. Tags: ARTICLES Source Type: journals

A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Celecoxib, 200 mg/d, for 6 weeks did not alter proteinuria. Few adverse events were noted in this high-risk population. PMID: 18037095 [PubMed - in process] (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - November 28, 2007 Category: Urology & Nephrology Authors: Sinsakul M, Sika M, Rodby R, Middleton J, Shyr Y, Chen H, Han E, Lehrich R, Clyne S, Schulman G, Harris R, Lewis J Tags: Am J Kidney Dis Source Type: journals

Differences in the Effect of Angiotensin-converting Enzyme Inhibitors on the Rate of Endothelial Cell Apoptosis: In Vitro and In Vivo StudiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our experiments suggest differences between ACE inhibitors in terms of inhibition of endothelial apoptosis in vivo. Content Type Journal ArticleDOI 10.1007/s10557-007-6068-5Authors C. Ceconi, University of Ferrara Department of Cardiology Corso Giovecca 203 44100 Ferrara ItalyG. Francolini, Foundation Salvatore Maugeri IRCCS Cardiovascular Pathophysiology Research Center Gussago ItalyD. Bastianon, Foundation Salvatore Maugeri IRCCS Cardiovascular Pathophysiology Research Center Gussago ItalyG.L. Gitti, Foundation Salvatore Maugeri IRCCS Cardiovascular Pathophysiology Research Center Gussago I...
Source: Cardiovascular Drugs and Therapy - November 15, 2007 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Prevention of vascular damage in scleroderma and autoimmune Raynaud's phenomenon: A multicenter, randomized, double-blind, placebo-controlled trial of the angiotensin-converting enzyme inhibitor quinaprilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate the efficacy and tolerability of prolonged administration of quinapril, a long-acting angiotensin-converting enzyme inhibitor, in the management of the peripheral vascular manifestations of limited cutaneous systemic sclerosis (lcSSc) and in the prevention of the progression of visceral organ involvement in the disease.This was a multicenter, randomized, double-blind, placebo-controlled study evaluating quinapril 80 mg/day, or the maximum tolerated dosage, in 210 patients with lcSSc or with Raynaud's phenomenon (RP) and the presence of SSc-specific antinuclear antibodies. Treatment was for 2-3 years. The primar...
Source: Arthritis and Rheumatism - October 29, 2007 Category: Rheumatology Authors: A. E. Gliddon, C. J. Doré, C. M. Black, N. McHugh, R. Moots, C. P. Denton, A. Herrick, T. Barnes, J. Camilleri, K. Chakravarty, P. Emery, B. Griffiths, N. D. Hopkinson, P. Hickling, P. Lanyon, C. Laversuch, T. Lawson, R. Mallya, M. Nisar, C. Rhys-Dillon, Source Type: journals

Does blockade of the Renin Angiotensin system affect sympathetic and blood pressure responses to amlodipine in young hypertensive patients?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: It appears that amlodipine does not activate the renin-angiotensin system to counteract its BP-lowering effect in young hypertensives. Similarly, no angiotensin II-dependent component in MSNA appears to be present at baseline or to be induced by amlodipine. PMID: 17954368 [PubMed - in process] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - October 24, 2007 Category: Cardiology Authors: Ruzicka M, Coletta E, Leenen FH Tags: Am J Hypertens Source Type: journals

Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiogensin converting enzyme inhibition.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SKELETAL MUSCLE CAPILLARY RESPONSES TO INSULIN ARE ABNORMAL IN LATE-STAGE DIABETES AND ARE RESTORED BY ANGIOGENSIN CONVERTING ENZYME INHIBITION. Am J Physiol Endocrinol Metab. 2007 Oct 2; Authors: Clerk LH, Vincent MA, Barrett E, Lankford MF, Lindner JR Acute physiologic hyperinsulinemia increases skeletal muscle capillary blood volume (CBV), presumably in order to augment glucose and insulin delivery. We hypothesized that insulin-mediated changes in CBV are impaired in type-2 diabetes mellitus (DM) and are improved by angiotensin converting enzyme inhibition (ACE-I). Zucker obese diabetic rats (ZDF, n=18) and ...
Source: Am J Physiol Endocri... - October 2, 2007 Category: Endocrinology Authors: Clerk LH, Vincent MA, Barrett E, Lankford MF, Lindner JR Tags: Am J Physiol Endocrinol Metab Source Type: journals

Effects of 2 Years Treatment with Quinapril on Carotid Intima Media in Type 1 Diabetes Mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 145Authors: Whisstock, C; Viscardi, L; Bianchi, F; Galbiati, M; Capra, A; Gamba, P L; Paleari, F; Giannattasio, C; Mancia, G (Source: High Blood Pressure & Cardiovascular Prevention)
Source: High Blood Pressure & Cardiovascular Prevention - September 29, 2007 Category: Cardiology Tags: HTML PDF (96 K) Source Type: journals

Degradation mechanism for a trace impurity in quinapril drug by tandem mass and precursor ions studies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 17708525 [PubMed - in process] (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - September 25, 2007 Category: Chemistry Authors: Shinde V, Trivedi A, Upadhayay PR, Gupta NL, Kanase DG, Chikate RC Tags: Rapid Commun Mass Spectrom Source Type: journals

The combination of ACE inhibition plus sympathetic denervation is superior to ACE inhibitor monotherapy in the rat renal ablation model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In angiotensin-converting enzyme inhibitor-treated SNX animals, abrogation of sympathetic overactivity provides additional renoprotection and less nitro-oxidative stress of podocytes than single interventions. The added benefits were partially blood pressure independent. PMID: 17347582 [PubMed - indexed for MEDLINE] (Source: Nephron Experimental Nephrology)
Source: Nephron Experimental Nephrology - September 6, 2007 Category: Urology & Nephrology Authors: Hamar P, Kokeny G, Liptak P, Krtil J, Adamczak M, Amann K, Ritz E, Gross ML Tags: Nephron Exp Nephrol Source Type: journals

FDA approves Teva's generic hypertension drugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Teva Pharmaceutical Industries Ltd. has received Food and Drug Administration approval to market a generic version of Pfizer's Accupril drug for hypertension. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - August 27, 2007 Category: Pharmaceuticals Source Type: journals

Quinapril for Treatment of Hypertension in Turkey: Dose Titration and Diuretic Combination Treatment StrategiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - August 22, 2007 Category: Drugs & Pharmacology Authors: Yener, GulAran, SinanBahceci, MithatOzdemir, KurtulusGultekin, FusunLowe, Wing Tags: Original Research Article Source Type: journals

Quinapril for Treatment of Hypertension in Turkey: Dose Titration and Diuretic Combination Treatment Strategies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 613Authors: Yener, Gul 1; Aran, Sinan 2; Bahceci, Mithat 3; Ozdemir, Kurtulus 4; Gultekin, Fusun 5; Lowe, Wing 6 (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - August 22, 2007 Category: Drugs & Pharmacology Tags: Abstract HTML PDF (247 K) Source Type: journals

Quinaretic(Quinapril Hydrochloride And Hydrochlorothiazide) Tablet [Actavis Totowa LLC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Aug 15, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - August 15, 2007 Category: Drugs & Pharmacology Source Type: organizations

Influence of enalapril, quinapril and losartan on lipopolysaccharide (LPS)-induced serum concentrations of TNF-alpha, IL-1beta, IL-6 in spontaneously hypertensive rats (SHR).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immunopharmacological studies of drugs used in cardiovascular diseases provide new data concerning their modulating effect on the levels of proinflammatory cytokines, chemokines and adhesion molecules. Therefore, we have made an attempt to find out whether enalapril, quinapril and losartan (drugs used in the treatment of arterial hypertension) are able to modulate lipopolysaccharide (LPS)-induced proinflammatory cytokine serum concentrations (tumor necrosis factor alpha - TNF-alpha, interleukin-1beta _ IL-1beta, interleukin-6 - IL-6) in spontaneously hypertensive rats (SHR). The animals were divided into four groups as...
Source: Pharmacological Reports - July 1, 2007 Category: Drugs & Pharmacology Authors: Andrzejczak D, Górska D, Czarnecka E Tags: Pharmacol Rep Source Type: journals

Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study sought to determine whether ACE inhibitors can directly regulate MMP activity and whether this results in positive structural and functional adaptations to the heart. To this end, MMP-2 activity in LV tissue extracted from rats with an aortocaval (AV) fistula was assessed by in vitro incubation as well as in vivo treatment with captopril, lisinopril, or quinapril. Furthermore, LV size and function were determined in untreated AV fistula rats, AV fistula rats treated with lisinopril (3, 5, and 8 wk), and age-matched sham-operated controls. In vitro incubation with captopril, lisinopril, or quinapril significantly...
Source: AJP: Heart and Circulatory Physiology - June 11, 2007 Category: Cardiology Authors: Brower, G. L., Levick, S. P., Janicki, J. S. Tags: ARTICLES Source Type: journals