Accutane
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Ranbaxy recalls over 4,000 cartons of acne drug in US
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Ranbaxy Laboratories has initiated a voluntary recall of 4,348 cartons of its best-selling drug Sotret (isotretinoin, 40 mg) used to treat acne in the US, as they are a part of one batch of tablets which were found to be ‘out of specification’. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - November 20, 2009 Category: Pharmaceuticals Source Type: news
Porokeratosis palmaris et plantaris disseminata or a disseminated late-onset variant of porokeratotic eccrine ostial and dermal ductal nevus (PEODDN) with follicular involvement.
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A 48-year-old woman presented with a four-year history of pruritic, hyperkeratotic, spiny papules that began on her chest and spread to her extremities, groin, palms, face, and scalp where it caused non-scarring alopecia. Histopathologic features included cornoid lamella, which is the hallmark of porokeratosis. However, the patient's constellation of findings does not meet diagnostic criteria for any of the five clinical variants of porokeratosis. Her presentation is most compatible with either porokeratosis palmaris et plantaris disseminata (PPPD), which is a rare variant of punctate porokeratosis that can involve any...
Source: Dermatol Online J - November 7, 2009 Category: Dermatology Authors: Hartman R, Rizzo C, Patel R, Kamino H, Shupack JL Tags: Dermatol Online J Source Type: journals
New study may deal final blow to acne drug Accutane
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The study bolstered evidence of a link between the drug, pulled from the market in June, and inflammatory bowel disease. No medication is as effective in treating severe cases of acne.
Teenagers and young adults suffering from severe, scarring acne may ultimately lose the most effective treatment for the condition. (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - November 7, 2009 Category: Science Source Type: news
New study may deal final blow to acne drug Accutane
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The study bolstered evidence of a link between the drug, pulled from the market in June, and inflammatory bowel disease. No medication is as effective in treating severe cases of acne.
Teenagers and young adults suffering from severe, scarring acne may ultimately lose the most effective treatment for the condition. (Source: L.A. Times - Health)
Source: L.A. Times - Health - November 7, 2009 Category: Consumer Health News Source Type: news
Isotretinoin's Mechanism of Action Explored
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PHILADELPHIA — Isotretinoin appears to derive its effectiveness from increased production of the antimicrobial protein neutrophil-gelatinase associated lipocalin in the skin, reducing sebum levels, and in turn reducing levels of Propionibacterium acnes, according to new data. (Source: Skin and Allergy News)
Source: Skin and Allergy News - November 1, 2009 Category: Dermatology Authors: KERRI WACHTER Tags: Pediatric Dermatology Source Type: journals
ACG: Acne Drug Tied to IBD (CME/CE)
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SAN DIEGO (MedPage Today) -- Use of the acne medication isotretinoin (Accutane) is associated with an increased risk of inflammatory bowel disease, researchers said here. (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - October 29, 2009 Category: Gastroenterology Source Type: news
Management of acne vulgaris: an evidence-based update
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This review summarizes clinically important findings from 3 systematic reviews, 1 updated guideline and a selection from the 62 randomized controlled trials (RCTs) published between February 2007 and January 2009 on the topic of acne vulgaris. Low glycaemic-load diets might reduce acne severity but this remains unproven. Written patient information leaflets have not been surpassed by other communication methods. New combination topical treatments have not shown convincing advantages over current combination products such as clindamycin/benzoyl peroxide. Topical dapsone is superior to placebo but has yet to be compared with...
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: J. R. Ingram, D. J. C. Grindlay, H. C. Williams Source Type: journals
CLARAVIS (Isotretinoin) Capsule [Barr Laboratories Inc.]
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Updated Date: Oct 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 20, 2009 Category: Drugs & Pharmacology Source Type: organizations
Roaccutane 10mg, 20mg capsules (isotretinoin) - Revised SPC
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Source: eMC (electronic Medicines Compendium)
Area: Other Library Updates > SPC Changes
Revised SPC - change to section 4.3. In addition to soya, isotretinoin is now also contra-indicated in patients allergic to peanuts. (Source: NeLM - SPC Changes)
Source: NeLM - SPC Changes - October 19, 2009 Category: Drugs & Pharmacology Source Type: organizations
Isotretinoin: Unmasking of autoimmune diabetes: case report
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(Source: Reactions)
Source: Reactions - October 19, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals
Isotretinoin/anti-GD2 monoclonal antibody interaction: First report of an interaction, leading to hypercalcaemia and osteoblastic lesions in a child: case report
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(Source: Reactions)
Source: Reactions - October 19, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals
Notes from the 8th International Symposium
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Patient advocates generously volunteered their time to take notes at the recent 8th International Kidney Cancer Symposium, in Chicago. These notes are intended to capture the essence of this important medical meeting and convey it in a way that is useful to patients, survivors, and their families. The first installment sumarizes the Saturday morning session.
Integration of Surgical and Systemic Therapy in Metastatic RCC
This session was opened by Dr. Bradley Leibovich who presented two cases on which the audience voted on methods to integrate surgery with systemic treatment int...
Source: Kidney Cancer Association - October 14, 2009 Category: Cancer & Oncology Source Type: organizations
As many as 68% of Dutch women taking the teratogen isotretinoin may not be concomitantly receiving hormonal contraception
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(Source: Reactions)
Source: Reactions - October 6, 2009 Category: Drugs & Pharmacology Tags: Research article Source Type: journals
Isotretinoin: Keloids: case report
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(Source: Reactions)
Source: Reactions - October 6, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals
Cervical and Vulvar Intraepithelial Neoplasia after Treatment with Oral Isotretinoin for Severe Acne Vulgaris
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Case Rep Dermatol 2009;1:49-51 (DOI:10.1159/000236034) (Source: Karger Publishers)
Source: Karger Publishers - September 29, 2009 Category: Cancer & Oncology Source Type: journals
Idiopathic pustular vulvitis
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A 31-year-old woman presented in the 23rd week of her third pregnancy with extremely painful pustular vulvitis, unresponsive to antibiotics. Although the histological findings were was consistent with a diagnosis of hidradenitis suppurativa (HS), bridged comedones, the hallmark of this disease, were absent and there were no dermal sinuses. Incision and drainage of the pustules provided only temporary improvement, which was briefly maintained with oral clindamycin and topical steroids. After the birth, a course of isotretinoin produced almost total clearance, a response not typically found in HS. This patient's condition ma...
Source: Clinical And Experimental Dermatology - September 21, 2009 Category: Dermatology Authors: M. Dhanjal, F. Teixeira, O. Dadzie, G. Rose Source Type: journals
Isotretinoin: Psychiatric disorders: 3 case reports
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(Source: Reactions)
Source: Reactions - September 21, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals
Depressive symptoms and suicidal ideation during isotretinoin treatment: a 12-week follow-up study of male Finnish military conscripts. - Rehn L, Meririnne E, Höök-Nikanne J, Isometsä E, Henriksson M.
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Objective: To investigate the putative association between isotretinoin treatment and depressive symptoms or suicidal ideation among Finnish male military conscripts. Methods Consecutive acne patients were enrolled into an uncontrolled, prospective 12-week... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - September 13, 2009 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: info
Isotretinoin: Congenital ear malformation following in utero exposure: case report
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(Source: Reactions)
Source: Reactions - September 7, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals
Specific gel-cream as adjuvant to oral isotretinoin improved hydration and prevented TEWL increase – a double-blind, randomized, placebo-controlled study
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Conclusions Compared with placebo, the specific gel-cream with active products as an adjuvant to oral isotretinoin improved hydration, prevented TEWL increase, and reduced inflammatory acne lesions after 30 days. (Source: Journal of Cosmetic Dermatology)
Source: Journal of Cosmetic Dermatology - August 31, 2009 Category: Dermatology Authors: María Isabel Herane, Héctor Fuenzalida, Emilia Zegpi, Carolina De Pablo, Maria José Espadas, Carles Trullás, Alfons Mirada, Guillermo González Martin Tags: Original Contributions Source Type: journals
Prescription "Sharing" Among Teens Widespread, Dangerous
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08/10/2009, Journal of Adolescent Health, What if a teenager with acne who is taking Accutane - a drug linked to birth defects - gives some to her friend, who is pregnant but does not yet realize it? Unfortunately, this is a realistic scenario. (Source: Health Behavior News Service)
Source: Health Behavior News Service - August 28, 2009 Category: Consumer Health News Source Type: news
IBD Causation Expert Again Excluded From Accutane MDL
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TAMPA, Fla. - "Re-asserted" general causation testimony by plaintiff expert Dr. Ronald Fogel was excluded from the Accutane multidistrict litigation for a second time on Aug. 11 when a judge found that his opinion that the acne drug causes inflammatory bowel disease (IBD) still overreaches data on which it is based (In Re: Accutane Products Liability, MDL Docket No. 1626, No. 04-md-2523, M.D. Fla., Tampa Div.; See 3/5/09, Page 15).
Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)
Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News - August 22, 2009 Category: Medical Law Source Type: info
Generic Accutane Case Remanded In Illinois; Doctor's Joinder Proper
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CHICAGO - An Illinois federal judge on Aug. 6 remanded an Accutane case to state court after finding that the plaintiff is a state resident and that two medical co-defendants are not fraudulently misjoined (Stephen Livingston v. Hoffman-La Roche Inc., et al., No. 09-2611, N.D. Ill., Eastern Div.; 2009 U.S. Dist. LEXIS 70242).
Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)
Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News - August 22, 2009 Category: Medical Law Source Type: info
Standard guidelines of care: Lasers for tattoos and pigmented lesions
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Aurangabadkar Sanjeev, Mysore VenkataramIndian Journal of Dermatology, Venereology, and Leprology 2009 75(8):111-126<b>Introduction: </b> Lasers have revolutionized the treatment of pigmentary disorders and have become the mainstay of therapy for many of them. <b> Machines:</b> Though different laser machines are used, Quality-switched (QS) lasers are considered as the gold standard for treatment of pigmented lesions. Proper knowledge of the physics of laser machine, methodology, dosage schedules, etc., is mandatory. <b> Phy...
Source: Indian Journal of Dermatology, Venereology and Leprology - August 12, 2009 Category: Dermatology Authors: Aurangabadkar Sanjeev, Mysore Venkataram Source Type: journals
ADRAC is reminding prescribers that isotretinoin has been linked to acquired hearing impairment.
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(Source: Reactions)
Source: Reactions - August 10, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals
40% Of US Teenagers Share Diverse Prescription Drugs, With Possibly Dangerous And Even Deadly Consequences
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Imagine one teenager who has acne giving some Accutane, a prescription medication, to a friend. The friend is pregnant and does not know it yet. Accutane is linked to birth defects. This kind of scenario among adolescents is much more common than people realize in the USA. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 10, 2009 Category: Consumer Health News Tags: Pediatrics / Children's Health Source Type: news
Roche Cites New Study Finding Accutane Not Linked To IBD In Users
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TAMPA - Hoffman-La Roche Inc. on July 24 notified the federal and New Jersey Accutane courts of a July 21 medical journal article that concluded that it is unlikely that Accutane (isotretinoin) is associated with the development of inflammatory bowel disease (IBD), one of the central claims in the litigation (In Re: Accutane Products Liability, MDL Docket No. 1626, No. 04-md-2523, M.D. Fla., Tampa Div., and In Re: Accutane Litigation, No. 271 MT, Jordan Speisman v. Hoffman-La Roche Inc., No. ATL-L-196-05 MT, Lance Speisman v. Hoffman-La Roche Inc., No. ATL-L-197-05 MT, Kelly Mace v. Hoffman-La Roche Inc., No. ATL-L-199-05 ...
Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News - August 8, 2009 Category: Medical Law Source Type: info
Accutane Pull Won't Affect Access to Isotretinoin
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Citing a significant loss of market share, Roche announced that it will cease manufacturing the retinoid Accutane, but dermatologists say that the company's pullout will not affect patients' access to the drug and will not have any impact on the risk management program known as iPledge. (Source: Skin and Allergy News)
Source: Skin and Allergy News - July 31, 2009 Category: Dermatology Authors: ALICIA AULT Tags: News Source Type: journals
Demise of Accutane Won't Affect Access to Isotretinoin
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Citing a significant loss of market share, Roche announced in June that it will cease manufacturing the retinoid Accutane, but dermatologists say that the company's pullout will not affect patients' access to the drug and will not have any impact on the risk management program known as iPledge. (Source: Family Practice News)
Source: Family Practice News - July 31, 2009 Category: Primary Care Authors: ALICIA AULT Tags: Skin Disorders Source Type: news
Association between oral isotretinoin therapy and unmasked latent immuno-mediated diabetes.
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PMID: 19638521 [PubMed - in process] (Source: Diabetes Care)
Source: Diabetes Care - July 31, 2009 Category: Endocrinology Authors: Dicembrini I, Bardini G, Rotella CM Tags: Diabetes Care Source Type: journals
Accutane Retrial Postponed 1 Week, But Pending Appeal May Put It Off Longer
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ATLANTIC CITY, N.J. - The retrial of a New Jersey Accutane inflammatory bowel disease (IBD) case will be postponed by one week to accommodate a defense attorney whose father died, the defense decided July 21 after the Atlantic County Superior Court judge refused a defense request to move the retrial to October or December (Andrew McCarrell v. Hoffman-La Roche Inc., et al., No. ATL-L-1951-03 MT, N.J. Super., Atlantic Co.; See 7/2/09, Page 25).
Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)
Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News - July 25, 2009 Category: Medical Law Source Type: info
N.J. Accutane Plaintiff Again Seeks Exclusion Of Numbers Of Drug Users
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ATLANTIC CITY, N.J. - A plaintiff in an Accutane retrial on July 10 asked a New Jersey state trial court to again exclude evidence about the over number of Accutane users - the very issue that sent the case back for retrial (Andrew McCarrell v. Hoffman-La Roche Inc., et al., No. ATL-L:-1951-03, N.J. Super., Atlantic Co.; See 7/2/09, Page 25).
Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)
Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News - July 25, 2009 Category: Medical Law Source Type: info
Neuroblastoma: treatment outcome after incomplete resection of primary tumors
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Conclusions For intermediate risk, conventional chemotherapy appears to be acceptable treatment. However, for high-risk patients, every
effort should be made to control residual disease including the use of myeloablative chemotherapy, differentiating agents
and immune-modulating agents.
Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00383-009-2417-8Authors
Suk-Bae Moon, Seoul National University Children’s Hospital Department of Pediatric Surgery Seoul KoreaKwi-Won Park, Seoul National University Children’s Hospital Department of Pediatric Surgery Seoul KoreaSung-Eun Jung, Seoul...
Source: Pediatric Surgery International - July 25, 2009 Category: Surgery Tags: Pediatric Surgery International Source Type: journals
[Original articles] Treatment of acne with oral isotretinoin in patients with cystic fibrosis
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Conclusions:
Adolescents with cystic fibrosis and acne can be treated with oral isotretinoin. Oral isotretinoin should be considered for adolescents with cystic fibrosis who have acne associated with scarring, acne not clearing with topical and antibiotic treatment, acne associated with depression or severe cystic acne. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 22, 2009 Category: Pediatrics Authors: Perera, E, Massie, J, Phillips, R J Tags: Liver disease, Pancreas and biliary tract, Drugs: infectious diseases, Malnutrition, Child and adolescent psychiatry (paedatrics), Cystic fibrosis, Dermatology Original articles Source Type: journals
OBSERVATION: Cyclosporine-Induced Infantile Nodulocystic Acne
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Conclusions Nodulocystic acne may be induced by the use of cyclosporine in children as well as adults. When it occurs, it can be managed with cessation of cyclosporine therapy and treatment with isotretinoin. Because this management approach may influence other outcomes in children with transplants, it is best to treat these patients using a multidisciplinary approach. (Source: Archives of Dermatology)
Source: Archives of Dermatology - July 19, 2009 Category: Dermatology Authors: Strahan, J. E., Burch, J. M. Tags: Dermatology, Dermatologic Disorders, Acne, Pediatrics, Neonatology and Infant Care, Surgery, Surgical Interventions, Cardiovascular/ Cardiothoracic Surgery, Transplantation, Cardiac Transplantation, Dermatologic Disorders, Other, Drug Therapy, Adverse Eff Source Type: journals
Treatment Options For Acne Patients Post Accutane's Withdrawal From US Market
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Roche Holding AG, the world's biggest maker of cancer drugs, recently announced the withdrawal of its Accutane acne medicine from the US Market. (Source: Pharmaceutical Online News)
Source: Pharmaceutical Online News - July 15, 2009 Category: Pharmaceuticals Source Type: news
Accutane (Isotretinoin) - updated on RxList
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Accutane (Isotretinoin) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 9, 2009 Category: Drugs & Pharmacology Source Type: consumer
Acne Drug Accutane No Longer Sold
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Generic versions of the acne drug are still available as isotretinoin. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 8, 2009 Category: Consumer Health News Tags: Dermatology Source Type: news
Acne Drug Accutane No Longer Sold
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Citing "business reasons" -- declining sales and the cost of defending personal injury lawsuits -- Roche has stopped making Accutane. Generic versions are available. (Source: WebMD Health)
Source: WebMD Health - July 8, 2009 Category: Consumer Health News Source Type: news
N.J. Accutane Retrial Won't Be Stayed To Allow Appeal
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ATLANTIC CITY, N.J. - The July 27 retrial of a $2.6 million Accutane inflammatory bowel disease (IBD) case will not be stayed so defendant Hoffman-La Roche Inc. can ask the New Jersey Supreme Court to review a trial court order denying its motion to have new experts testify, a state court judge ruled June 24 (In Re: Accutane Litigation, No. 271 MT, N.J. Super., Atlantic Co.).
Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)
Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News - July 7, 2009 Category: Medical Law Source Type: info
Roche Discontinues Accutane Due To Generic Competition
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NUTLEY, N.J. - Hoffman-La Roche Inc. told the Food and Drug Administration on June 26 that it intends to immediately discontinue production of Accutane brand isotretinoin because competition from generic competitors has dropped its market share to 5 percent.
Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)
Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News - July 7, 2009 Category: Medical Law Source Type: info
Isotretinoin: Hypertriglyceridaemia: case report.
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Page: 20 (Source: Reactions Weekly)
Source: Reactions Weekly - July 7, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals
Roche stops selling Accutane, can't compete with generics
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Zurich, Switzerland - Swiss drugmaker Roche Holding AG has decided to stop selling Accutane
(isotretinoin), as it has reached the end of its life cycle and cannot compete with generic alternatives, Reuters
reports. (Source: Modern Medicine)
Source: Modern Medicine - July 6, 2009 Category: Journals (General) Source Type: info
Isotretinoin: Hypertriglyceridaemia: case report
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(Source: Reactions)
Source: Reactions - July 6, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals
Looking to the future: Derms foresee changes connected to practice management, science
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Cosmetic dermatology procedures have dramatically changed the face of dermatology. Accutane, lasers,
sunscreens, biologics, fillers and Botox are just a few of the additions made to the specialty's armamentarium
throughout the past three decades. (Source: Modern Medicine)
Source: Modern Medicine - June 30, 2009 Category: Journals (General) Source Type: info
A case of suspected isotretinoin-induced malformation in a baby of a mother who became pregnant one month after discontinuation of the drug.
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We present a case of both-ear malformation in a newborn whose mother had taken isotretinoin for 2 years until one month prior to the time when she became pregnant. We suggest that further studies of pharmacokinetics and malformation of isotretinoin are needed.
PMID: 19568610 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - June 29, 2009 Category: Universities & Medical Training Authors: Lee SM, Kim HM, Lee JS, Yoon CS, Park MS, Park KI, Namgung R, Lee C Tags: Yonsei Med J Source Type: journals
Roche stops selling acne drug Accutane
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ZURICH (Reuters) - Swiss drugmaker Roche Holding AG is no longer selling its acne drug Accutane as it has reached the end of its life cycle and is losing ground to generic alternatives, the company said on Friday. (Source: Reuters: Health)
Source: Reuters: Health - June 26, 2009 Category: Consumer Health News Tags: healthNews Source Type: news
11th Circuit Upholds Accutane Summary Judgment In Case Involving Congressman's Son
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ATLANTA - The wife of U.S. Rep. Bart Stupak, D-Mich., failed to produce evidence that Hoffman-La Roche Inc. knew or should have known that Accutane could cause suicide without premonitory symptoms, a federal appeals panel ruled June 10 in a case involving the suicide of the couple's son while taking the acne drug (Laurie A. Stupak v. Hoffman-La Roche Inc., et al., No. 07-15980, 11th Cir.; 2009 U.S. App. LEXIS 12482; See 5/15/08.).
Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)
Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News - June 26, 2009 Category: Medical Law Source Type: info
Roche Can't Name New Experts In Accutane IBD Retrial
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ATLANTIC CITY, N.J. - Hoffman-La Roche Inc. on June 12 lost its bid to replace its expert witnesses in an Accutane retrial next month (Andrew McCarrell v. Hoffman-La Roche Inc., et al., No. ATL-L-1951-03-MT, N.J. Super., Atlantic Co.; See 6/4/09.).
Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)
Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News - June 26, 2009 Category: Medical Law Source Type: info
