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Novel insights about class 2 integrons from experimental and genomic epidemiology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In order to contribute to the knowledge of the architecture and epidemiology of class 2 integrons, we performed a class 2 integron molecular survey analyzing 726 isolates in two bacterial populations, from environmental and non-epidemiologically related clinical samples, respectively, collected during 1982-2007. We recovered the intI2 gene in 130 out of 726 isolates, of which most were clinical isolates, and only one (a psychrophilic Pseudomonas spp.) was from a water sample. Unlike the widespread distribution of class 1 integrons within gram-negative bacilli, only Acinetobacter baumannii and Enterobacter cloacae harbor...
Source: Antimicrobial Agents and Chemotherapy - November 16, 2009 Category: Microbiology Authors: Ramírez MS, Piñeiro S, , Centrón D Tags: Antimicrob Agents Chemother Source Type: journals

The allergy-protective properties of Acinetobacter lwoffii F78 are imparted by its lipopolysaccharideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We found evidence that the allergy-protecting effects of A. lwoffii F78 are because of the activation of a TH1-polarizing program in human dendritic cells, and that the LPS of A. lwoffii F78 is responsible for these beneficial effects. (Source: Allergy)
Source: Allergy - November 12, 2009 Category: Allergy & Immunology Authors: J. Debarry, A. Hanuszkiewicz, K. Stein, O. Holst, H. Heine Source Type: journals

Meropenem: Lack of efficacy in an elderly patient with Acinetobacter baumannii infection: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 11, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Enhancing antibiotic activity: a strategy to control Acinetobacter infectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Susceptibility of MDR A. baumannii to a variety of antibiotics was enhanced in the presence of ellagic and tannic acids. The use of such plant compounds might provide effective treatments for resistant Gram-negative bacterial infections. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Chusri, S., Villanueva, I., Voravuthikunchai, S. P., Davies, J. Tags: Original research Source Type: journals

In vitro effect of physiological concentrations of human albumin on the antibacterial activity of tigecyclineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Correcting the total concentration for the reported literature binding values is unreliable since tigecycline antibacterial activity was greater than that suggested by the free fraction of the drug. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Alou, L., Gimenez, M.-J., Cafini, F., Aguilar, L., Sevillano, D., Gonzalez, N., Torrico, M., Prieto, J., Garcia-Rey, C., Garcia-Escribano, N. Tags: Original research Source Type: journals

Anti-Infective Strategies of the Future: Is there Room for Species-Specific Antibacterial Agents?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Broad-spectrum antibiotics, directed against conserved bacterial targets, are the mainstay of antibacterial therapy. Increasing resistance, however, demands new strategies. Over time a number of therapeutic concepts have evolved, starting out with the use of polyclonal antisera, which were rapidly replaced by the easier to use antibiotics. Other concepts, such as immunotherapy, radioimmunotherapy, anti-virulence agents, phage therapy and others are under evaluation and often limited in application. In the discovery process of new antibiotics in the pharmaceutical industry quite a number of new agents have emerged, whic...
Source: Current Pharmaceutical Design - November 10, 2009 Category: Drugs & Pharmacology Authors: Then RL, Sahl HG Tags: Curr Pharm Des Source Type: journals

Epidemiology and Impact of Imipenem Resistance in Acinetobacter baumannii • Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Many A. baumannii isolates exhibit imipenem resistance, which is strongly associated with prior use of carbapenems. Given the high mortality rate associated with A. baumannii infection or colonization, interventions to curb further emergence of cases of IRAB infection and strategies to optimize therapy are needed. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - November 4, 2009 Category: Epidemiology Tags: article Original Article Source Type: journals

Multidrug-Resistant Acinetobacter Infections Remain Prevalent In and Out of HospitalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Infection control practices reduced the rate of multidrug resistant Acinetobacter in an intensive care unit and should be implemented in patients at risk for community-onset infections. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 4, 2009 Category: Consumer Health News Tags: Infectious Diseases Source Type: news

C-reactive protein and interleukin-6 responses for differentiating fungal and bacterial aetiology in late-onset neonatal sepsisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the predictive value of the combined evaluation of the C-reactive protein (CRP) and interleukin-6 (IL-6) responses for differentiating fungal and bacterial aetiologies in patients with NS. From January to September 2007, neonates who were diagnosed with NS and had their CRP and IL-6 levels measured were selected. Based on their blood culture results, the neonates were divided into two groups: group of fungal sepsis (FS) and group of bacterial sepsis (BS). FS included 14 Candida albicans and one non-albicans Candida isolates and BS included five Klebsiella pneumoniae, three Pseudomonas aeruginosa, three ...
Source: Mycoses - November 3, 2009 Category: Research Authors: Suna Serife Oguz, Erden Sipahi, Ugur Dilmen Source Type: journals

Vacuum-assisted closure and bilateral pectoralis muscle flaps for different stages of mediastinitis after cardiac surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Early BPMMF is an effective surgical treatment for DSWI in patients with an unstable sternum and osteomyelitis. VAC may be considered for patients without osteomyelitis but a stable sternum, or as adjuvant therapy in patients with comorbidity. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00595-008-3982-5Authors Zeynep Eyileten, University of Ankara School of Medicine Department of Cardiovascular Surgery, Heart Centre Dikimevi, Ankara 06340 TurkeyAhmet Ruchan Akar, University of Ankara School of Medicine Department of Cardiovascular Surgery, Heart Centre Dikimevi, Ankara...
Source: Surgery Today - November 2, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Screening and Quantification of the Expression of Antibiotic Resistance Genes in Acinetobacter baumannii with a Microarray.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An oligonucleotide-based DNA microarray was developed to evaluate expression of genes for efflux pumps in Acinetobacter baumannii and to detect acquired antibiotic resistance determinants. The microarray contained probes for 205 genes including those for 47 efflux systems, 55 resistance determinants, and 35 housekeeping genes. The microarray was validated by comparative analysis of mutants overexpressing or deleted for the pumps relative to the parental strain. The performance of the microarray was also evaluated using in vitro single step mutants obtained on various antibiotics. Overexpression, confirmed by quantitati...
Source: Antimicrobial Agents and Chemotherapy - November 2, 2009 Category: Microbiology Authors: Coyne S, Guigon G, Courvalin P, Périchon B Tags: Antimicrob Agents Chemother Source Type: journals

First isolation of the blaOXA-23 carbapenemase gene from an environmental Acinetobacter baumannii.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acinetobacter baumannii is frequently associated with nosocomial infections and its increasing resistance to carbapenems, may significantly reduce the choice of effective antibiotics (2). ... PMID: 19884362 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - November 2, 2009 Category: Microbiology Authors: Girlich D, Poirel L, Nordmann P Tags: Antimicrob Agents Chemother Source Type: journals

Genetic diversity of phthalic acid esters-degrading bacteria isolated from different geographical regions of China.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thirty-two strains of phthalic acid ester (PAEs)-degrading bacteria were isolated from thirteen geographically diverse sites by enrichment using mixtures of PAEs as the sole source of carbon and energy. Sequence analyses of the 16S rRNA gene indicated that these isolates were from six genera (Arthrobacter, Gordonia, Rhodococcus, Acinetobacter, Pseudomonas, and Delftia). To evaluate the genetic diversity among them, the molecular typing method rep-PCR with primers based on enterobacterial repetitive intergenic consensus, repetitive extragenic palindromes, and BOXAIR sequences was performed. Strain-specific and unique ge...
Source: Antonie van Leeuwenhoek - October 29, 2009 Category: Microbiology Authors: Liang R, Wu X, Dai Q, Jin D, Wang Y Tags: Antonie Van Leeuwenhoek Source Type: journals

Epidemiology and Impact of Imipenem Resistance in Acinetobacter baumanniiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Many A. baumannii isolates exhibit imipenem resistance, which is strongly associated with prior use of carbapenems. Given the high mortality rate associated with A. baumannii infection or colonization, interventions to curb further emergence of cases of IRAB infection and strategies to optimize therapy are needed. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - October 27, 2009 Category: Epidemiology Tags: article Original Article Source Type: journals

Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii in a Newly Established Greek HospitalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Microbial Drug Resistance Dec 2009, Vol. 15, No. 4: 257-260. (Source: Microbial Drug Resistance)
Source: Microbial Drug Resistance - October 26, 2009 Category: Microbiology Tags: article Source Type: journals

Specificity and Mechanism of Acinetobacter baumanii Nicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug Pyrazinamide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19859929 [PubMed - as supplied by publisher] (Source: Angewandte Chemie)
Source: Angewandte Chemie - October 26, 2009 Category: Chemistry Authors: Fyfe PK, Rao VA, Zemla A, Cameron S, Hunter WN Tags: Angew Chem Int Ed Engl Source Type: journals

Community-acquired Acinetobacter baumannii meningitis in a previously healthy 14-month-old boyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a previously healthy 14-month-old boy who developed community-acquired Acinetobacter baumannii meningitis. He had no history of immunodeficiency, and was brought to Konan Kosei Hospital with a high fever and vomiting. His consciousness was clear, but neck stiffness was noted. Examination of the cerebrospinal fluid (CSF) revealed a cell count of 10 112/µl; protein, 216 mg/dl; and glucose, 9 mg/dl. A CSF test kit for bacterial capsular antigens (Pastorex Meningitis; Bio-Rad Laboratories) was positive for Haemophilus influenzae type b antigen. On day 3 of admission, the microorganism isolated by CSF culture was ...
Source: Journal of Infection and Chemotherapy - October 24, 2009 Category: Infectious Diseases Tags: Journal of Infection and Chemotherapy Source Type: journals

Acinetobacter sp. Ud-4 Efficiently Degrades Both Edible and Mineral Oils: Isolation and Characterization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A novel Acinetobacter strain, Ud-4, possessing a strong capacity to degrade edible, lubricating, and heavy oil was isolated from seawater in a fishing port located in Toyama, Japan. It was identified by morphological and physiological analyses and 16S rDNA sequencing. This strain could utilize five types of edible oils (canola oil, olive oil, sesame oil, soybean oil, and lard), lubricating oil, and C-heavy oil as the sole carbon source for growth in M9 medium. The strain grew well and heavily degraded edible oils in Luria-Bertani medium during a 7-day culture at 25 degrees C; it also degraded all kinds of oils in artif...
Source: Current Microbiology - October 21, 2009 Category: Microbiology Authors: Tanaka D, Takashima M, Mizuta A, Tanaka S, Sakatoku A, Nishikawa A, Osawa T, Noguchi M, Aizawa SI, Nakamura S Tags: Curr Microbiol Source Type: journals

Intrathecal colistin for drug-resistant Acinetobacter baumannii central nervous system infection: a case series and systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clin Microbiol Infect Treatment limitations exist for drug-resistant Acinetobacter baumannii central nervous system (CNS) infection. We conducted a retrospective study and systematic literature review to identify patients with drug-resistant A. baumannii CNS infection who received primary or adjunct intrathecal or intraventricular (IT/IVT) colistin. In a case series of seven Thai patients and 17 patients identified in the literature, clinical and microbiological cure rates with IT/IVT colistin therapy were 83% and 92%, respectively. Three patients (13%) developed chemical ventriculitis and one (4%) experienced treatment-as...
Source: Clinical Microbiology and Infection - October 20, 2009 Category: Microbiology Authors: T. Khawcharoenporn, A. Apisarnthanarak, L. M. Mundy Source Type: journals

Med Sci Monit 2009; 15(11):CS163-165 "Successful treatment of a critical burn patient with obstinate hyperglycemia and septic shock from pan-drug-resistant strains"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The critical burn patient developed a series of severe complications during the course of treatment. Correct management of these complications is crucial to success in the treatment of such patients. (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 19, 2009 Category: Research Tags: Case report Source Type: journals

Attributable Hospital Cost and Length of Stay Associated with Healthcare Associated Infections Caused by Antibiotic-Resistant, Gram-Negative Bacteria.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to determine the additional total hospital cost and LOS attributable to healthcare associated infections (HAIs) caused by antibiotic-resistant, gram-negative (GN) pathogens. A single-center, retrospective, observational comparative cohort study was performed involving 662 patients admitted from 2000-2008 who developed HAI caused by one of following pathogens: Acinetobacter spp., Enterobacter spp., E. coli, Klebsiella spp. or Pseudomonas spp. Attributable total hospital cost and LOS for antibiotic- resistant GN HAIs were determined via comparison with a control group having HAIs due to antibi...
Source: Antimicrobial Agents and Chemotherapy - October 18, 2009 Category: Microbiology Authors: Mauldin PD, Salgado CD, Hansen IS, Durup DT, Bosso JA Tags: Antimicrob Agents Chemother Source Type: journals

Summary trends for the Meropenem Yearly Susceptibility Test Information Collection Program: a 10-year experience in the United States (1999–2008)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) Program was a global, longitudinal antimicrobial resistance surveillance network of more than 100 medical centers worldwide monitoring the susceptibility of meropenem and selected other broad-spectrum comparator agents. In 1999, and from 2000 through 2008, a total of 10 or 15 United States (USA) medical centers each forwarded 200 nonduplicate clinical isolates from serious infections to a central processing laboratory. Over the 10-year period of this surveillance program, the activity of meropenem and an average of 11 other antimicrobial age...
Source: Diagnostic Microbiology and Infectious Disease - October 16, 2009 Category: Microbiology Authors: Paul R. Rhomberg, Ronald N. Jones Tags: Antimicrobial Susceptibility Studies Source Type: journals

Serum resistance of Acinetobacter baumannii through the binding of factor H to outer membrane proteinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bacteremia is a common systemic disease caused by Acinetobacter baumannii, an important hospital-acquired pathogen among critically ill patients. The complement system is central to innate immune defense against invading bacteria in the blood. The present study investigated the susceptibility of clinical A. baumannii isolates to normal human sera (NHS), and determined the resistance mechanism of A. baumannii against complement-mediated lysis. The survival of A. baumannii isolates from bacteremic patients was significantly decreased in undiluted NHS, but they were resistant to 40% NHS. The alternative complement pathway was...
Source: FEMS Microbiology Letters - October 13, 2009 Category: Microbiology Authors: Sang Woo Kim, Chul Hee Choi, Dong Chan Moon, Jong Sook Jin, Jung Hwa Lee, Ji-Hyun Shin, Jung Min Kim, Yoo Chul Lee, Sung Yong Seol, Dong Taek Cho, Je Chul Lee Source Type: journals

Leaching and transformability of transgenic DNA in unsaturated soil columns.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Unsaturated soil columns were used to examine the transport of the plasmid pLEPO1 and plant DNA (transplastomic tobacco DNA), both carrying an antibiotic resistance gene (aadA gene), and the capacity of bacteria to incorporate the gene in their genome after its passage through the soil. Soil columns containing a top leaf layer had sterile water percolated through them at a rate of 0.5mLh(-1). DNA from column leachate water was extracted and analyzed. Quantitative measurements included total DNA concentrations in the water and the transformation frequencies of Acinetobacter sp. BD413 by DNA in the column effluent. Quali...
Source: Ecotoxicology and Environmental Safety - October 11, 2009 Category: Environmental Health Authors: Poté J, Teresa Ceccherini M, Rosselli W, Wildi W, Simonet P, Vogel TM Tags: Ecotoxicol Environ Saf Source Type: journals

Acinetobacter spp as emerging pathogen in neonatal septicemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Scientific Letters to the EditorDOI 10.1007/s12098-009-0176-0Authors Madhu Sharma, Pt. B.D. Sharma PGIMS Department of Microbiology Rohtak Haryana IndiaSarita Yadav, Pt. B.D. Sharma PGIMS Department of Microbiology Rohtak Haryana IndiaUma Chaudhary, Pt. B.D. Sharma PGIMS Department of Microbiology Rohtak Haryana India Journal Indian Journal of PediatricsOnline ISSN 0973-7693Print ISSN 0019-5456 Journal Volume Volume 76 Journal Issue Volume 76, Number 8 / August, 2009 (Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - October 3, 2009 Category: Pediatrics Tags: Indian Journal of Pediatrics Source Type: journals

Methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii on computer interface surfaces of hospital wards and association with clinical isolatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: With good hand hygiene compliance, we found relatively low contamination rates of MRSA, P. aeruginosa and A. baumannii on ward computer interface, and without further contribution to nosocomial infection. Our results suggested no necessity of routine culture surveillance in non-outbreak situation. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - September 30, 2009 Category: Infectious Diseases Authors: Po-Liang LuL. k SiuTun-Chieh ChenLing MaWen-Gin ChiangYen-Hsu ChenSheng-Fung LinTyen-Po Chen Source Type: journals

Is the Use of Low-Pressure Pulsatile Lavage for Pressure Ulcer Management Associated With Environmental Contamination With Acinetobacter baumannii?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Low-pressure pulsatile lavage using the infection control methods described is not associated with an increased rate of environmental contamination of A. baumannii in comparison with standard dressing changes. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - September 30, 2009 Category: Rehabilitation Authors: Chester H. Ho, Tova Johnson, Joan Miklacic, Curtis J. Donskey Tags: Original Articles Source Type: journals

Acinetobacter baumannii-Associated Skin and Soft Tissue Infections: Recognizing a Broadening Spectrum of DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Surgical Infections , Vol. 0, No. 0. (Source: Surgical Infections)
Source: Surgical Infections - September 29, 2009 Category: Surgery Tags: article Source Type: journals

First isolation of Enterobacter, Enterococcus, and Acinetobacter spp. as inhabitants of the tsetse fly (Glossina palpalis palpalis) midgut.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper reports the first evidence of the presence of bacteria, other than the three previously described as symbionts, Wigglesworthia glossinidia, Wolbachia, and Sodalis glossinidius, in the midgut of Glossina palpalis palpalis, the tsetse fly, a vector of the chronic form of human African trypanosomiasis in sub-Saharan African countries. Based on morphological, nutritional, physiological, and phylogenetic results, we identified Enterobacter, Enterococcus, and Acinetobacter spp. as inhabitants of the midgut of the tsetse fly. Enterobacter spp. was the most frequently isolated. The role of these bacteria in the gut,...
Source: Infection, Genetics and Evolution - September 28, 2009 Category: Genetics & Stem Cells Authors: Geiger A, Fardeau ML, Grebaut P, Vatunga G, Josénando T, Herder S, Cuny G, Truc P, Ollivier B Tags: Infect Genet Evol Source Type: journals

2-DE analysis indicates that Acinetobacter baumannii displays a robust and versatile metabolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This work indicates that A. baumannii has a versatile and robust metabolism and also reveal a number of proteins that may play a key role in the mechanism of drug resistance and virulence. The data obtained complements earlier reports of A.baumannii proteome and provides new tools to increase our knowledge on the protein expression profile of this pathogen. (Source: BioMed Central)
Source: BioMed Central - September 27, 2009 Category: Journals (General) Authors: Nelson SoaresMaria CabralJose ParreiraCarmen GayosoMaria BarbaGerman Bou Source Type: journals

Antimicrobial Properties of Brevinin-2-Related Peptide and its Analogs: Efficacy Against Multidrug-Resistant Acinetobacter baumanniiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Brevinin-2 related peptide (B2RP; GIWDTIKSMG10KVFAGKILQN20L.NH2), first isolated from skin secretions of the mink frog Lithobates septentrionalis, shows broad-spectrum antimicrobial activity but its therapeutic potential is limited by moderate hemolytic activity. The peptide adopts an [alpha]-helical conformation in a membrane-mimetic solvent but amphipathicity is low. Increasing amphipathicity together with hydrophobicity by the substitutions Lys16[rarr]Leu and Lys16[rarr]Ala increased hemolytic activity approximately fivefold without increasing antimicrobial potency. The substitution Leu18[rarr]Lys increased both cationi...
Source: Chemical Biology and Drug Design - September 27, 2009 Category: Biology Authors: J. Michael Conlon, Eman Ahmed, Eric Condamine Source Type: journals

Bactericidal activity in filtrated supernatant of Streptococcus sanguinis against multidrug-resistant Pseudomonas aeruginosa.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the past decade, multidrug-resistant Pseudomonas aeruginosa (MDRP) infection has become a serious clinical problem, due to the limitation of drug choices to fight against the bacteria. Here we explored the bactericidal activity in the filtrated supernatant of Streptococcus (S.) sanguinis against Pseudomonas (P.) aeruginosa. S. sanguinis is one of the alpha-hemolytic streptococci that commonly reside in the human oral cavity. A strain of S. sanguinis, isolated from the sputum of a pulmonary-disease patient, was cultured for overnight. The filtered supernatant was tested for bactericidal effect using the minimum bacte...
Source: The Tohoku Journal of Experimental Medicine - September 26, 2009 Category: Research Authors: Watanabe K, Senba M, Ichinose A, Yamamoto T, Ariyoshi K, Matsumoto K Tags: Tohoku J Exp Med Source Type: journals

Colistin and polymyxin B: A re-emergenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gupta Sachin, Govil Deepak, Kakar Prem N, Prakash Om, Arora Deep, Das Shibani, Govil Pradeep, Malhotra AshimaIndian Journal of Critical Care Medicine 2009 13(2):49-53One of the greatest achievements of modern medicine is the development of antibiotics against life-threatening infections, but the emergence of multidrug-resistant (MDR) gram negative bacteria has drastically narrowed down the therapeutic options against them. This limitation has led clinicians to reappraise the clinical application of polymyxins, an old class of cationic, cyclic polypeptide antibiotics. Polymyxins are active against selected gram-negative bac...
Source: Indian Journal of Critical Care Medicine - September 26, 2009 Category: Intensive Care Authors: Gupta Sachin, Govil Deepak, Kakar Prem N, Prakash Om, Arora Deep, Das Shibani, Govil Pradeep, Malhotra Ashima Source Type: journals

Non-adherence to guidelines: an avoidable cause of failure of empirical antimicrobial therapy in the presence of difficult-to-treat bacteriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Despite the abundant information for the treatment of VAP and the establishment of guidelines, too many patients with DTT bacteria received inappropriate antimicrobial therapy. Since 45% of the cases are related to non-adherence to the local protocol, there is room for improvement by implementing educational programs. Also, since DTT bacteria are found in 23% of late-onset VAP, empirical antibiotic treatment should be directed against these pathogens. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1660-8Authors Frédéric Garcin, Université de la Méditerranée Servic...
Source: Intensive Care Medicine - September 24, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Differential proteomics of the plasma of individuals with sepsis caused by Acinetobacter baumannii.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examines alterations in the plasma proteome in ten adults affected by sepsis caused by Acinetobacter baumannii as compared to paired healthy controls. 2-DE profiles of plasma from patients and paired healthy donors, depleted of the six most abundant proteins, were analysed by the DIGE technique. Protein spot detection and quantification were performed with the Differential In-gel Analysis and Biological Variation Analysis modules of the DeCyder(TM) software. Differentially expressed proteins were identified by mass spectrometry (MALDI-TOF/TOF) after colloidal Coomassie blue staining. Almost 900 spots were detect...
Source: Journal of Proteomics - September 23, 2009 Category: Biochemistry Authors: Soares AJ, Santos MF, Trugilho MR, Ferreira AG, Perales J, Domont GB Tags: J Proteomics Source Type: journals

Antibiotic resistance in clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus does not impact sensitivity to human beta defensin 4Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Antibiotic usage is essential for infection control but hastens emergence of antibiotic resistant microbes. In particular, Acinetobacter baumannii is an important pathogen because of its heightened ability to acquire drug resistance. The need for novel antibacterial agents led us to evaluate the sensitivity of drug-resistant bacteria to the antimicrobial activity of human beta defensin 4 (HBD-4). Clinical isolates of A. baumannii (N=14), Pseudomonas aeruginosa (N=15), and Staphylococcus aureus (N=20), including 10 methicillin-resistant (MRSA) isolates, were examined. All bacterial strains were susceptible to HBD-...
Source: Burns : Journal of the International Society for Burn Injuries - September 22, 2009 Category: Cosmetic Surgery Authors: Dorothy M. Supp, Jason Gardner, Jennifer M. Klingenberg, Alice N. Neely Tags: Articles Source Type: journals

The role of a novel efflux pump AbeS, member of the SMR family of transporters in resistance to antimicrobial agents in Acinetobacter baumannii.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, a chromosomally-encoded putative drug efflux pump of the SMR family, named AbeS, from a multidrug-resistant strain of Acinetobacter baumannii, was characterized to elucidate its role in antimicrobial resistance. Expression of the cloned abeS gene in hypersensitive Escherichia coli host KAM32 resulted in decreased susceptibility to various classes of antimicrobial agents, detergents and dyes. Deletion of the abeS gene in A. baumannii confirmed its role in conferring resistance to these compounds. PMID: 19770280 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - September 20, 2009 Category: Microbiology Authors: Srinivasan VB, Rajamohan G, Gebreyes WA Tags: Antimicrob Agents Chemother Source Type: journals

OXA-143, a Novel Carbapenem-Hydrolyzing Class D ss-Lactamase in Acinetobacter baumannii.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study identified a novel class D ss-lactamase involved in carbapenem resistance in A. baumannii. This enzyme is the first member of a novel subgroup of CHDLs which prevalence remains to be determined. PMID: 19770279 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - September 20, 2009 Category: Microbiology Authors: Higgins PG, Poirel L, Lehmann M, Nordmann P, Seifert H Tags: Antimicrob Agents Chemother Source Type: journals

Production of cell–cell signalling molecules by bacteria isolated from human chronic woundsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Chronic wound bacteria produce cell[ndash]cell signalling molecules. Based on our findings, we hypothesize that resident species generally produce AI-2 molecules, and aggressive transient species associated with chronic wounds typically produce AHLs. Both these classes of cell[ndash]cell signals are indicated to be present in human chronic wounds.Significance and Impact of the Study: Interbacterial cell[ndash]cell signalling may be an important factor influencing wound development and if this is the case, the presence of AHLs and AI-2 could be used as a predictor of wound severity. Manipulation of cell[ndash]ce...
Source: Journal of Applied Microbiology - September 20, 2009 Category: Microbiology Authors: A.H. Rickard, K.R. Colacino, K.M. Manton, R.I. Morton, E. Pulcini, J. Pfeil, D. Rhoads, R.D. Wolcott, G. James Source Type: journals

Carbapenem-Resistant Acinetobacter baumannii Producing the OXA-23 Enzyme: Dissemination in Southern BrazilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s15010-009-9003-9Authors A. F. Martins, Universidade Federal do Rio Grande do Sul, Coordenadoria de Vigilância em Saúde de Porto Alegre Medical Sciences Post-Graduate Program 372/3 Padre Cacique Avenue Porto Alegre RS 90000-000 BrazilR. Kuchenbecker, Hospital de Clínicas de Porto Alegre Hospital Infection Control Committee Porto Alegre BrazilT. Sukiennik, Complexo HospitalarSanta Casa Hospital Infection Control Committee Porto Alegre BrazilR. Boff, Centro Universitário IPA Metodista Porto Alegre BrazilK. C. Reiter, Universidade Federal do Rio Grande do ...
Source: Infection - September 18, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

In vitro activities of moxifloxacin and tigecycline against bacterial isolates associated with intraabdominal infections at a medical center in Taiwan, 2001–2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study found that moxifloxacin and tigecycline exhibited good in vitro activity against bacterial isolates causing IAIs. Content Type Journal ArticleCategory ArticleDOI 10.1007/s10096-009-0801-xAuthors C.-Y. Liu, National Taiwan University College of Medicine Department of Internal Medicine, National Taiwan University Hospital Taipei TaiwanC.-L. Lu, National Taiwan University College of Medicine Department of Internal Medicine, National Taiwan University Hospital Taipei TaiwanY.-T. Huang, National Taiwan University College of Medicine Department of Laboratory Medicine, National Taiwan University Hospital Taipei T...
Source: European Journal of Clinical Microbiology & Infectious Diseases - September 17, 2009 Category: Microbiology Tags: European Journal of Clinical Microbiology & Infectious Diseases Source Type: journals

The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honeyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Tualang honey exhibited variable activities against different microorganisms, but they were within the same range as those for manuka honey. This result suggests that tualang honey could potentially be used as an alternative therapeutic agent against certain microorganisms, particularly A. baumannii and S. maltophilia. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - September 14, 2009 Category: Complementary Medicine Authors: Hern Tze TanRosliza Abdul RahmanSiew Hua GanAhmad Sukari HalimSiti Asma' HassanSiti Amrah SulaimanKirnpal-Kaur S Source Type: journals

Selection of colistin-resistant Acinetobacter baumannii isolates in postneurosurgical meningitis in an intensive care unit with high presence of heteroresistance to colistinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Colistin heteroresistance in Acinetobacter baumannii (Ab) has been reported, but the clinical impact and the antimicrobial treatment have not been established yet. We observed the selection intratreatment with colistin of Ab colistin-resistant strains from a colistin-heteroresistant isolate in one patient with postneurosurgical meningitis. The presence and the genetic relationship of heteroresistant Ab isolates from intensive care units (ICUs) obtained in the same period of the case report were analyzed. Twenty-eight isolates from patients admitted to the ICUs of an Argentinian university hospital during June to ...
Source: Diagnostic Microbiology and Infectious Disease - September 14, 2009 Category: Microbiology Authors: Rodriguez Carlos Hernan, Bombicino Karina, Granados Gabriela, Nastro Marcela, Vay Carlos, Famiglietti Angela Tags: Case Reports Source Type: journals

Azathioprine/methylprednisolone/methotrexate: Lobular panniculitis due to Acinetobacter and MRSA infections: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 14, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

beta-Lactamase Inhibitors: The Story so Far.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antimicrobial resistance constitutes one of the major threats regarding pathogenic microorganisms. Gram-negative pathogens, such as Enterobacteriaceae (specially those producing extended-spectrum beta-lactamases), Pseudomonas aeruginosa, and Acinetobacter baumannii have acquired an important role in hospital infections, which is of particular concern because of the associated broad spectrum of antibiotic resistance. beta-Lactam antibiotics are considered the most successful antimicrobial agents since the beginning of the antibiotic era. Soon after the introduction of penicillin, microorganisms able to destroy this beta...
Source: Current Medicinal Chemistry - September 12, 2009 Category: Chemistry Authors: Pérez-Llarena FJ, Bou G Tags: Curr Med Chem Source Type: journals

Antimicrobial therapy and aerobic bacteriologic culture patterns in canine intensive care unit patients: 74 dogs (January–June 2006)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Describe antimicrobial therapy and aerobic bacteriologic culture patterns in canine intensive care unit (ICU) patients in a university hospital. Retrospective descriptive. A tertiary university referral hospital. Seventy-four canine ICU patients. From January to June 2006 patient antimicrobial use, minimum inhibitory concentration (MIC) results, and clinical data were recorded. Appropriate antimicrobial use was analyzed relative to the time of culture submission and MIC results. Mean±SD age was 7.2±4.2 years. Median (range) length of ICU and hospital stays were 3 days (1[ndash]25 d) and 4 days (1[ndash]27 d), respectivel...
Source: Journal of Veterinary Emergency and Critical Care - September 10, 2009 Category: Veterinary Research Authors: Dorothy M. Black, Shelley C. Rankin, Lesley G. King Source Type: journals

Impact of early appropriate antimicrobial therapy on survival in Acinetobacter baumannii bloodstream infectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The impact of appropriate empirical antimicrobial therapy for Acinetobacter baumannii bacteraemia on patient outcomes has not been clearly established. We assessed predictors of 30-day mortality and the effect of inappropriate empirical antimicrobial treatment on mortality among patients with A. baumannii bacteraemia between July 2005 and June 2008. Initial empirical antimicrobial therapy was considered to be appropriate if the initial antibiotics that were administered within 48h after the acquisition of a blood culture sample included at least one antibiotic that was active in vitro and when the dosage and rout...
Source: International Journal of Antimicrobial Agents - September 9, 2009 Category: Drugs & Pharmacology Authors: Ayşe Erbay, Aysun İdil, M. Gökhan Gözel, İpek Mumcuoğlu, Neriman Balaban Tags: Full length articles Source Type: journals

Comparison of tigecycline penetration into the epithelial lining fluid of infected and uninfected murine lungsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions While tigecycline exhibits excellent ELF penetration in healthy and infected murine lungs, the presence of infection greatly enhances penetration. Moreover, increased systemic exposures of tigecycline result in greater ELF penetration, regardless of infection status. When future tigecycline clinical trials for the treatment of pneumonia are considered, escalated doses may reap greater than expected benefits towards achieving adequate pharmacodynamic indexes within the lungs. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - September 8, 2009 Category: Microbiology Authors: Crandon, J. L., Kim, A., Nicolau, D. P. Tags: Original research Source Type: journals

Carbapenem-resistant Acinetobacter baumannii infections after organ transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
P. Reddy, T.R. Zembower, M.G. Ison, T.A. Baker, V. Stosor. Carbapenem-resistant Acinetobacter baumannii infections after organ transplantation.Transpl Infect Dis 2009. All rights reservedAbstract: Multi-drug resistant (MDR) gram-negative infections among solid organ transplant (SOT) recipients have long been associated with high morbidity and mortality. Acinetobacter baumannii has emerged as a potent nosocomial pathogen with the recent acquisition of resistance to broad-spectrum [beta]-lactams, aminoglycosides, fluoroquinolones, and most notably, carbapenems. Despite a national rise in carbapenem-resistant A. baumannii (CR...
Source: Transplant Infectious Disease - September 7, 2009 Category: Transplant Surgery Authors: P. Reddy, T.R. Zembower, M.G. Ison, T.A. Baker, V. Stosor Source Type: journals

In vitro Activity of Nemonoxacin, a Novel Non-fluorinated Quinolone, against 2,440 Clinical Isolates.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The in vitro activity of nemonoxacin, a novel non-fluorinated quinolone, was tested against 2,440 clinical isolates. Nemonoxacin was at least 4 fold more active than levofloxacin and moxifloxacin against most Gram-positive cocci tested [MIC90/range (microg/ml): community-associated methicillin-resistant Staphylococcus aureus, 0.5/0.015-2; Staphylococcus epidermidis, 0.5/0.015-4 (methicillin-susceptible), 2/0.12-2 (methicillin-resistant); Streptococcus pneumoniae, 0.015/</=0.008-0.25; Enterococcus faecalis, 1/0.03-128]. Activity against Gram-negative bacilli was similar to levofloxacin and moxifloxacin [MIC90/range (...
Source: Antimicrobial Agents and Chemotherapy - September 7, 2009 Category: Microbiology Authors: Adam HJ, Laing NM, King CR, Lulashnyk B, Hoban DJ, Zhanel GG Tags: Antimicrob Agents Chemother Source Type: journals