Acta Biochimica et Biophysica Sinica 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
Prostate cancer-associated transcript 6 (PCAT6) promotes epithelial-mesenchymal transition and stemness and worsens prognosis in patients with colorectal cancer
In this study, we find that elevated expression of PCAT6 is independently linked to unfavourable survival outcomes in The Cancer Genome Atlas (TCGA) data, and this finding is further confirmed in CRC samples obtained from Fudan University Shanghai Cancer Center. Cell lines and xenograft mouse models are used to examine the impact of PCAT6 on tumor metastasis. Knockdown of PCAT6 is observed to impede the metastatic phenotype of CRC, as evidenced by functional assays, demonstrating the suppression of epithelial-mesenchymal transition (EMT) and stemness. Our findings show the significance of PCAT6 in mCRC and its potential us...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Xun Sun Yitao Yuan Suyao Li Lu Gan Midie Xu Qingguo Li Mengling Liu Keshu Hu Ke Nan Jiayu Zhang Yu Dong Yufu Lin Xiuping Zhang Pengcong Hou Tianshu Liu Source Type: research
< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
Prostate cancer-associated transcript 6 (PCAT6) promotes epithelial-mesenchymal transition and stemness and worsens prognosis in patients with colorectal cancer
In this study, we find that elevated expression of PCAT6 is independently linked to unfavourable survival outcomes in The Cancer Genome Atlas (TCGA) data, and this finding is further confirmed in CRC samples obtained from Fudan University Shanghai Cancer Center. Cell lines and xenograft mouse models are used to examine the impact of PCAT6 on tumor metastasis. Knockdown of PCAT6 is observed to impede the metastatic phenotype of CRC, as evidenced by functional assays, demonstrating the suppression of epithelial-mesenchymal transition (EMT) and stemness. Our findings show the significance of PCAT6 in mCRC and its potential us...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Xun Sun Yitao Yuan Suyao Li Lu Gan Midie Xu Qingguo Li Mengling Liu Keshu Hu Ke Nan Jiayu Zhang Yu Dong Yufu Lin Xiuping Zhang Pengcong Hou Tianshu Liu Source Type: research
< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
Prostate cancer-associated transcript 6 (PCAT6) promotes epithelial-mesenchymal transition and stemness and worsens prognosis in patients with colorectal cancer
In this study, we find that elevated expression of PCAT6 is independently linked to unfavourable survival outcomes in The Cancer Genome Atlas (TCGA) data, and this finding is further confirmed in CRC samples obtained from Fudan University Shanghai Cancer Center. Cell lines and xenograft mouse models are used to examine the impact of PCAT6 on tumor metastasis. Knockdown of PCAT6 is observed to impede the metastatic phenotype of CRC, as evidenced by functional assays, demonstrating the suppression of epithelial-mesenchymal transition (EMT) and stemness. Our findings show the significance of PCAT6 in mCRC and its potential us...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Xun Sun Yitao Yuan Suyao Li Lu Gan Midie Xu Qingguo Li Mengling Liu Keshu Hu Ke Nan Jiayu Zhang Yu Dong Yufu Lin Xiuping Zhang Pengcong Hou Tianshu Liu Source Type: research
< em > Lycium barbarum < /em > polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism
In this study, we hypothesize that LBP alleviates LD accumulation in adipose tissue (AT) by inhibiting fat-specific protein 27 (Fsp27) through an activating transcription factor-6 (ATF6)/small-molecule sirtuin 1 (SIRT1)-dependent mechanism. LD accumulation in AT is induced in high-fat diet (HFD)-fed mice, and differentiation of 3T3-L1 preadipocytes (PAs) is induced. The ability of LBP to alleviate LD accumulation and the possible underlying mechanism are then investigated both in vivo and in vitro. The influences of LBP on the expressions of LD-associated genes ( ATF6 and Fsp27) are also detected. The results show that HFD...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Rui Zhou Yajing Liu Weiqian Hu Jing Yang Bing Lin Zhentian Zhang Mingyan Chen Jingwen Yi Cuifeng Zhu Source Type: research
Prostate cancer-associated transcript 6 (PCAT6) promotes epithelial-mesenchymal transition and stemness and worsens prognosis in patients with colorectal cancer
In this study, we find that elevated expression of PCAT6 is independently linked to unfavourable survival outcomes in The Cancer Genome Atlas (TCGA) data, and this finding is further confirmed in CRC samples obtained from Fudan University Shanghai Cancer Center. Cell lines and xenograft mouse models are used to examine the impact of PCAT6 on tumor metastasis. Knockdown of PCAT6 is observed to impede the metastatic phenotype of CRC, as evidenced by functional assays, demonstrating the suppression of epithelial-mesenchymal transition (EMT) and stemness. Our findings show the significance of PCAT6 in mCRC and its potential us...
Source: Acta Biochimica et Biophysica Sinica - April 12, 2024 Category: Biochemistry Authors: Xun Sun Yitao Yuan Suyao Li Lu Gan Midie Xu Qingguo Li Mengling Liu Keshu Hu Ke Nan Jiayu Zhang Yu Dong Yufu Lin Xiuping Zhang Pengcong Hou Tianshu Liu Source Type: research
CTNNAL1 promotes the structural integrity of bronchial epithelial cells through the RhoA/ROCK1 pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 11. doi: 10.3724/abbs.2024026. Online ahead of print.ABSTRACTAdhesion molecules play critical roles in maintaining the structural integrity of the airway epithelium in airways under stress. Previously, we reported that catenin alpha-like 1 (CTNNAL1) is downregulated in an asthma animal model and upregulated at the edge of human bronchial epithelial cells (HBECs) after ozone stress. In this work, we explore the potential role of CTNNAL1 in the structural adhesion of HBECs and its possible mechanism. We construct a CTNNAL1 ‒/‒ mouse model with CTNNAL1-RNAi recombinant adeno-a...
Source: Acta Biochimica et Biophysica Sinica - April 11, 2024 Category: Biochemistry Authors: Caixia Liu Jinmei Wang Yurong Tan Chi Liu Xiangping Qu Huijun Liu Meiling Tan Changqing Deng Xiaoqun Qin Yang Xiang Source Type: research
CTNNAL1 promotes the structural integrity of bronchial epithelial cells through the RhoA/ROCK1 pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 11. doi: 10.3724/abbs.2024026. Online ahead of print.ABSTRACTAdhesion molecules play critical roles in maintaining the structural integrity of the airway epithelium in airways under stress. Previously, we reported that catenin alpha-like 1 (CTNNAL1) is downregulated in an asthma animal model and upregulated at the edge of human bronchial epithelial cells (HBECs) after ozone stress. In this work, we explore the potential role of CTNNAL1 in the structural adhesion of HBECs and its possible mechanism. We construct a CTNNAL1 ‒/‒ mouse model with CTNNAL1-RNAi recombinant adeno-a...
Source: Acta Biochimica et Biophysica Sinica - April 11, 2024 Category: Biochemistry Authors: Caixia Liu Jinmei Wang Yurong Tan Chi Liu Xiangping Qu Huijun Liu Meiling Tan Changqing Deng Xiaoqun Qin Yang Xiang Source Type: research
GroEL triggers NLRP3 inflammasome activation through the TLR/NF- κB p-p65 axis in human periodontal ligament stem cells
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 10. doi: 10.3724/abbs.2024050. Online ahead of print.ABSTRACTThe interaction between bacteria and the host plays a vital role in the initiation and progression of systemic diseases, including gastrointestinal and oral diseases, due to the secretion of various virulence factors from these pathogens. GroEL, a potent virulence factor secreted by multiple oral pathogenic bacteria, is implicated in the damage of gingival epithelium, periodontal ligament, alveolar bone and other peripheral tissues. However, the underlying biomechanism is still largely unknown. In the present study, w...
Source: Acta Biochimica et Biophysica Sinica - April 10, 2024 Category: Biochemistry Authors: Li Zhang Mengmeng Duan Xiaohua Pu Huiling Zheng Xinjie Ning Ying Tu Chunming Xu Demao Zhang Chengcheng Liu Jing Xie Source Type: research
GroEL triggers NLRP3 inflammasome activation through the TLR/NF- κB p-p65 axis in human periodontal ligament stem cells
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 10. doi: 10.3724/abbs.2024050. Online ahead of print.ABSTRACTThe interaction between bacteria and the host plays a vital role in the initiation and progression of systemic diseases, including gastrointestinal and oral diseases, due to the secretion of various virulence factors from these pathogens. GroEL, a potent virulence factor secreted by multiple oral pathogenic bacteria, is implicated in the damage of gingival epithelium, periodontal ligament, alveolar bone and other peripheral tissues. However, the underlying biomechanism is still largely unknown. In the present study, w...
Source: Acta Biochimica et Biophysica Sinica - April 10, 2024 Category: Biochemistry Authors: Li Zhang Mengmeng Duan Xiaohua Pu Huiling Zheng Xinjie Ning Ying Tu Chunming Xu Demao Zhang Chengcheng Liu Jing Xie Source Type: research
Carfilzomib activates ER stress and JNK/p38 MAPK signaling to promote apoptosis in hepatocellular carcinoma cells
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 9. doi: 10.3724/abbs.2024040. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the most prevalent and deadly cancers in the world, which is frequently diagnosed at a late stage. HCC patients have a poor prognosis due to the lack of an efficacious therapeutic strategy. Approved drug repurposing is a way for accelerating drug discovery and can significantly reduce the cost of drug development. Carfilzomib (CFZ) is a second-generation proteasome inhibitor, which is highly efficacious against multiple myeloma and has been reported to possess potential antitumo...
Source: Acta Biochimica et Biophysica Sinica - April 9, 2024 Category: Biochemistry Authors: Yao Deng Yujie Li Mingyue Yang Yang Gao Xuling Luo Hanbin Chen Meng Guo Xuefeng Yang Yongzhang Liu Jun He Bin Lu Naxin Liu Source Type: research
20(S)-Ginsenoside Rh2 inhibits hepatocellular carcinoma by suppressing angiogenesis and the GPC3-mediated Wnt/ β‑catenin signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 7. doi: 10.3724/abbs.2024038. Online ahead of print.ABSTRACT20(S)-Ginsenoside Rh2 has significant anti-tumor effects in various types of cancers, including human hepatocellular carcinoma (HCC). However, its molecular targets and mechanisms of action remain largely unknown. Here, we aim to elucidate the potential mechanisms by which Rh2 suppresses HCC growth. We first demonstrate the role of Rh2 in inhibiting angiogenesis. We observe that Rh2 effectively suppresses cell proliferation and induces apoptosis in HUVECs. Furthermore, Rh2 significantly inhibits HepG2-stimulated HUVEC ...
Source: Acta Biochimica et Biophysica Sinica - April 8, 2024 Category: Biochemistry Authors: Linfei Xu Jing Li Ningning Hou Fang Han Xiaodong Sun Qinying Li Source Type: research
20(S)-Ginsenoside Rh2 inhibits hepatocellular carcinoma by suppressing angiogenesis and the GPC3-mediated Wnt/ β‑catenin signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 7. doi: 10.3724/abbs.2024038. Online ahead of print.ABSTRACT20(S)-Ginsenoside Rh2 has significant anti-tumor effects in various types of cancers, including human hepatocellular carcinoma (HCC). However, its molecular targets and mechanisms of action remain largely unknown. Here, we aim to elucidate the potential mechanisms by which Rh2 suppresses HCC growth. We first demonstrate the role of Rh2 in inhibiting angiogenesis. We observe that Rh2 effectively suppresses cell proliferation and induces apoptosis in HUVECs. Furthermore, Rh2 significantly inhibits HepG2-stimulated HUVEC ...
Source: Acta Biochimica et Biophysica Sinica - April 8, 2024 Category: Biochemistry Authors: Linfei Xu Jing Li Ningning Hou Fang Han Xiaodong Sun Qinying Li Source Type: research
