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Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Acta Biomaterialia)
Source: Acta Biomaterialia - October 19, 2009 Category: Materials Science Source Type: journals

2010 Acta Materialia Materials and Society AwardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Acta Biomaterialia)
Source: Acta Biomaterialia - August 31, 2009 Category: Materials Science Source Type: journals

Recipients of the 2008 acta student awards.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Acta Biomaterialia)
Source: Acta Biomaterialia - August 27, 2009 Category: Materials Science Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Acta Biomaterialia)
Source: Acta Biomaterialia - August 27, 2009 Category: Materials Science Source Type: journals

Fabrication and characterization of oxygen-diffused titanium for biomedical applicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study a novel oxygen-diffused titanium (ODTi), fabricated by introducing oxygen into the titanium crystal lattice by thermal treatment, was investigated. The fabricated material is the result of a surface modification made on commercially pure titanium (cp Ti) previously coated with poly(vinyl alcohol) (PVA) by means of a thermal treatment performed at 700°C in an ultra-pure argon atmosphere. The thermal treatment at 700°C led to the formation of an anatase TiO2 film on the cp Ti surface and a concentration gradient of oxygen into titanium. The surface of the fabricated ODTi consisted of an outer nanometric layer...
Source: Acta Biomaterialia - June 10, 2009 Category: Materials Science Authors: Osamu Yamamoto, Kelly Alvarez, Tamotsu Kikuchi, Masayuki Fukuda Source Type: journals

Fluoride-containing bioactive glasses: Surface reactivity in simulated body fluids solutionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The issue of the contribution of the addition of F to glass bioactivity is not well resolved. This work reports on the surface reactivity in different solutions (DMEM and Tris) for some potentially bioactive glasses based on the composition of 45S5 glass, in which CaF2 is substituted alternately for (part of) CaO and Na2O. The reactivity of F-containing glasses has been compared with that of the reference 45S5 system. The aim of this study is to explain in detail the mechanism of formation of an apatitic crystalline phase at the interface between the inorganic material and simulated biological media. A multi-tech...
Source: Acta Biomaterialia - June 10, 2009 Category: Materials Science Authors: G. Lusvardi, G. Malavasi, L. Menabue, V. Aina, C. Morterra Source Type: journals

Direct effect of alginate purification on the survival of islets immobilized in alginate-based microcapsulesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Alginate purification has been shown to decrease the host immune response to implanted alginate-based microcapsules, but the direct effect of contaminants on islet cell survival remains unknown. Wistar rat islets were immobilized in calcium alginate beads made with crude vs. purified alginate and then incubated in CMRL culture medium. Islet survival was evaluated at 1, 4, 7, 14 and 27days post-encapsulation. Islet viability was investigated using a dual staining assay (propidium iodide and orange acridine). The islet cell necrosis and the proportion of apoptotic cells were quantified under optical microscopy and ...
Source: Acta Biomaterialia - June 9, 2009 Category: Materials Science Authors: Geneviève Langlois, Julie Dusseault, Stéphanie Bilodeau, Susan K. Tam, Dalla Magassouba, Jean-Pierre Hallé Source Type: journals

Comparative corrosion study of Ti–Ta alloys for dental applicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Besides other important material features, the corrosion parameters and corrosion products are responsible for limiting the biocompatibility of metallic materials, and can produce undesirable reactions in implant-adjacent and/or more distant tissues. Titanium and some of its alloys are known as being the most biocompatible metallic materials due to their high strength, low modulus, high corrosion resistance in biological media, etc. More recently, Ti–Ta alloys have been developed, and these are expected to become more promising candidates for biomedical and dental applications than commercially pure Ti, Ti–6A...
Source: Acta Biomaterialia - June 7, 2009 Category: Materials Science Authors: Daniel Mareci, Romeu Chelariu, Doina-Margareta Gordin, Gina Ungureanu, Thierry Gloriant Source Type: journals

Porous TiNbZr alloy scaffolds for biomedical applicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In the present study, porous Ti–10Nb–10Zr alloy scaffolds with different porosities were successfully fabricated by a “space-holder” sintering method. By the addition of biocompatible alloying elements the porous TiNbZr scaffolds achieved significantly higher strength than unalloyed Ti scaffolds of the same porosity. In particular, the porous TiNbZr alloy with 59% porosity exhibited an elastic modulus and plateau stress of 5.6GPa and 137MPa, respectively. The porous alloys exhibited excellent ductility during compression tests and the deformation mechanism is mainly governed by bending and buckling of the...
Source: Acta Biomaterialia - June 7, 2009 Category: Materials Science Authors: Xiaojian Wang, Yuncang Li, Jianyu Xiong, Peter D. Hodgson, Cui’e Wen Source Type: journals

Radio-opaque bioactive glass markers for radiostereometric analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the study was to test the hypothesis that resorbable radio-opaque bioactive glass markers can be used in radiostereometric analysis (RSA). Cones made from (1) bioactive glass 1-06 with 2.5wt.% BaSO4, (2) glass 1-06 with 10wt.% BaSO4, (3) glass 1-06 without any additives and (4) nearly inert glass were created. The in vitro surface reactivity, as a surrogate of bioactivity, was analyzed using a simulated body fluid (SBF) immersion test. The in vivo performance was evaluated in the rat femur using biomechanical testing as well as histological and microcomputed tomography analysis of marker incorporation into...
Source: Acta Biomaterialia - June 7, 2009 Category: Materials Science Authors: Rami Madanat, Niko Moritz, Erik Vedel, Erkki Svedström, Hannu T. Aro Source Type: journals

Biodegradable hydrogels based on novel photopolymerizable guar gum–methacrylate macromonomers for in situ fabrication of tissue engineering scaffoldsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Guar gum (GG) is a non-ionic polysaccharide that is found abundantly in nature and has many properties desirable for biomedical applications. In the present work GG with molecular weights ranging from 74 to 210kDa was modified with glycidyl methacrylate (GMA) to produce a series of water-soluble photopolymerizable guar gum–methacrylate (GG–MA) macromonomers of different molecular weights. We investigated the effects of molecular weight of GG–MA macromonomers from 102 to 216kDa and with percent degree of methacrylation (%DM) ranging from 14% to 56% on the properties of GG–MA hydrogels. GG–MA hydrogels ex...
Source: Acta Biomaterialia - June 7, 2009 Category: Materials Science Authors: Ashutosh Tiwari, Jamison J. Grailer, Srikanth Pilla, Douglas A. Steeber, Shaoqin Gong Source Type: journals

A novel nanostructured poly(lactic-co-glycolic-acid)–multi-walled carbon nanotube composite for blood-contacting applications: Thrombogenicity studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Composite films of poly(lactic-co-glycolic-acid) with multi-walled carbon nanotubes (PLGA–MWCNT) having two different nanotube orientations, namely random and vertically aligned, have been fabricated and characterized. The effect of these nanostructured surfaces on platelet adhesion is evaluated. In particular, the thrombogenicity of the nanostructured composite films is compared with that of pristine graphite (a low thrombogenic material) and PLGA film, in order to determine the influence of surface chemistry and topography on platelet adhesion. The results in this study show that the PLGA–MWCNT composite wi...
Source: Acta Biomaterialia - June 7, 2009 Category: Materials Science Authors: Li Buay Koh, Isabel Rodriguez, Subbu S. Venkatraman Source Type: journals

Cell–matrix interactions and dynamic mechanical loading influence chondrocyte gene expression and bioactivity in PEG-RGD hydrogelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The pericellular matrix (PCM) surrounding chondrocytes is thought to play an important role in transmitting biochemical and biomechanical signals to the cells, which regulates many cellular functions including tissue homeostasis. To better understand chondrocytes interactions with their PCM, three-dimensional poly(ethylene glycol) (PEG) hydrogels containing Arg–Gly–Asp (RGD), the cell-adhesion sequence found in fibronectin and which is present in the PCM of cartilage, were employed. RGD was incorporated into PEG hydrogels via tethers at 0.1, 0.4 and 0.8mM concentrations. Bovine chondrocytes were encapsulated ...
Source: Acta Biomaterialia - June 7, 2009 Category: Materials Science Authors: Idalis Villanueva, Courtney A. Weigel, Stephanie J. Bryant Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Acta Biomaterialia)
Source: Acta Biomaterialia - June 6, 2009 Category: Materials Science Source Type: journals

Enhanced osteocalcin expression by osteoblast-like cells (MC3T3-E1) exposed to bioactive coating glass (SiO2–CaO–P2O5–MgO–K2O–Na2O system) ionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study tested the hypothesis that bioactive coating glass (SiO2–CaO–P2O5–MgO–K2O–Na2O system), used for implant coatings, enhanced the induction of collagen type 1 synthesis and in turn enhanced the expression of downstream markers alkaline phosphatase, Runx2 and osteocalcin during osteoblast differentiation. The ions from experimental bioactive glass (6P53-b) and commercial BioglassTM (45S5) were added to osteoblast-like MC3T3-E1 subclone 4 cultures as a supplemented ion extract (glass conditioned medium (GCM)). Ion extracts contained significantly higher concentrations of Si and Ca (Si, 47.9±10.4ppm; Ca, 6...
Source: Acta Biomaterialia - June 2, 2009 Category: Materials Science Authors: V.G. Varanasi, E. Saiz, P.M. Loomer, B. Ancheta, N. Uritani, S.P. Ho, A.P. Tomsia, S.J. Marshall, G.W. Marshall Source Type: journals

Polyelectrolyte multilayer films functionalized with peptides for promoting osteoblast functionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Layer-by-layer deposition of polyelectrolyte multilayer (PEM) thin films has recently been applied to biomaterial applications. This simple and versatile technique provides a wide variety of potential utilization by insertion of biomolecules such as cell adhesion peptides. In this work dual peptides containing RGD (a cell-binding domain) and LHRRVKI (a heparin-binding domain) were immobilized onto polystyrene by the PEM technique and the effects on osteoblast cell culture were investigated. These peptides were conjugated to the amino groups of poly(allylamine hydrochloride) and then adsorbed onto the top of a 10 ...
Source: Acta Biomaterialia - June 2, 2009 Category: Materials Science Authors: Wei-Bor Tsai, Rita Pei-Yeh Chen, Kuang-Ling Wei, Yi-Ru Chen, Tai-Yan Liao, Hsuan-Liang Liu, Juin-Yih Lai Source Type: journals

Comparative cytotoxicity of five current dentin bonding agents: Role of cell cycle deregulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: To compare the cytotoxicity of three nano-dentin bonding agents (nano-DBAs) and two non-nano-DBAs using Chinese hamster ovary (CHO-K1) cells. We found that nano fillers were not the major contributing factor in DBA cytotoxicity, as analyzed by colony forming assay and 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. Exposure of CHO-K1 cells to all three tested total-etching DBAs led to G0/G1 cell cycle arrest, whereas exposure to higher concentrations of two tested nano-DBAs induced G2/M arrest. All five DBAs further induced apoptosis at the highest concentration, as analyzed by propidi...
Source: Acta Biomaterialia - June 2, 2009 Category: Materials Science Authors: Hung-Wei Yeh, Mei-Chi Chang, Chun-Pin Lin, Wan-Yu Tseng, Hsiao-Hua Chang, Tong-Mei Wang, Yi-Jane Chen, Chiu-Chun Lin, Ting-Ting Yang, Li-Deh Lin, Jiiang-Huei Jeng Source Type: journals

Cell viability in a wet silica gelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A modified two-step sol–gel route using silicon ethoxide (TEOS) has been used to synthesize amorphous sol–gel-derived silica, which has been successfully used as a cell encapsulation matrix for 3T3 mouse fibroblasts and CRL-2595 epithelial cells due to its non-toxicity. The sol–gel procedure comprised a first, low pH hydrolysis step, followed by a neutral condensation–gelation step. A high water-to-TEOS ratio and the addition of d-glucose as a porogen and source of nutrients were chosen to minimize silica dissolution and improve the biocompatibility of the process. Indeed, the cell integrity in the encaps...
Source: Acta Biomaterialia - May 28, 2009 Category: Materials Science Authors: Alejandra Nieto, Sami Areva, Timothy Wilson, Reeta Viitala, Maria Vallet-Regi Source Type: journals

Peri-implant and systemic release of metallic elements following insertion of a mandibular modular endoprosthesis in Macaca fascicularisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this study quantified the release of only aluminum in lymph nodes and distant organs, when using a modular endoprosthesis made of Ti–6Al–4V for mandibular reconstruction. (Source: Acta Biomaterialia)
Source: Acta Biomaterialia - May 27, 2009 Category: Materials Science Authors: S. Lee, B.T. Goh, S.H. Lai, H. Tideman, P.J.W. Stoelinga, J.A. Jansen Source Type: journals

Gelation studies of a cellulose-based biohydrogel: The influence of pH, temperature and sterilizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The present paper investigates the rheological properties of silated hydroxypropylmethylcellulose (Si-HPMC) biohydrogel used for biomaterials and tissue engineering applications. The general property of this modified cellulose ether is the occurrence of self-hardening due to silanol condensation subsequent to a decrease in pH (from 12.4 to nearly 7.4). The behavior of unsterilized and sterilized Si-HPMC solutions in diluted and concentrated domains is first described and compared. In addition, the influence of physiological parameters such as pH and temperature on the rate of the gelation process is studied. In d...
Source: Acta Biomaterialia - May 27, 2009 Category: Materials Science Authors: Ahmed Fatimi, Jean-François Tassin, Roman Turczyn, Monique A.V. Axelos, Pierre Weiss Source Type: journals

In vitro integration of human skin dermis with porous cationic hydrogelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Porous poly(DMAA-co-AMTAC) hydrogels, fabricated using the inverted colloid crystal method, were used to observe their integration with human skin. Full thickness human breast skin explants discarded from surgeries were cultured for up to 10days at the air–liquid interface using a Transwell culture system. Cylindrical, disk- or other shaped hydrogels were placed inside the skin explants fitting punctures produced by punch biopsies or scalpels and full section histological analysis of the skin explants with the inserted hydrogel was then performed. In addition, separated hydrogels were cultured up to 7days with ...
Source: Acta Biomaterialia - May 27, 2009 Category: Materials Science Authors: Antonio Peramo, Joong Hwan Bahng, Cynthia L. Marcelo, Nicholas Kotov, David C. Martin Source Type: journals

Investigation of surface endothelialization on biomedical nitinol (NiTi) alloy: Effects of surface micropatterning combined with plasma nanocoatingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, endothelialization on biomedical nitinol alloy surfaces was systematically investigated. Our study focuses on elucidating the effects of surface micropatternings with micropores and microgrooves combined with plasma nanocoating. Plasma nanocoatings with controlled thickness between 40 and 50nm were deposited onto micropatterned nitinol surface in a direct current plasma reactor. Bovine aortic endothelial cells were cultured in vitro on these nitinol samples for 1, 3 and 5days. It was found that rougher surfaces could enhance cell adhesion compared with the smoother surfaces; the surfaces patterned with micro...
Source: Acta Biomaterialia - May 26, 2009 Category: Materials Science Authors: Yang Shen, Guixue Wang, Liang Chen, Hao Li, Ping Yu, Mengjun Bai, Qin Zhang, James Lee, Qingsong Yu Source Type: journals

Characterization, physicochemical properties and biocompatibility of La-incorporated apatitesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the physicochemical properties and biocompatibilities of La-containing apatites were intensively investigated together with their characterizations in terms of composition, structure, valent state and morphology using X-ray diffraction, Fourier-transform infrared spectra, X-ray photoelectron spectroscopy, scanning electron microscopy and energy dispersive X-ray spectroscopy, respectively. The results indicate that the La3+ ion can be incorporated into the crystal lattice of hydroxyapatite resulting in the production of La-incorporated apatites (LaxCa10−x(PO4)6(OH)2+x−2yOy□y−x (x⩽0.5, y (Source: Acta Biomaterialia)
Source: Acta Biomaterialia - May 26, 2009 Category: Materials Science Authors: D.G. Guo, A.H. Wang, Y. Han, K.W. Xu Source Type: journals

Guided bone regeneration by poly(lactic-co-glycolic acid) grafted hyaluronic acid bi-layer films for periodontal barrier applicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A novel protocol for the synthesis of biocompatible and degradation controlled poly(lactic-co-glycolic acid) grafted hyaluronic acid (HA-PLGA) was successfully developed for periodontal barrier applications. HA was chemically modified with adipic acid dihydrazide (ADH) in the mixed solvent of water and ethanol, which resulted in a high degree of HA modification up to 85mol.%. The stability of HA-ADH to enzymatic degradation by hyaluronidase increased with ADH content in HA-ADH. When the ADH content in HA-ADH was higher than 80mol.%, HA-ADH became soluble in dimethyl sulfoxide and could be grafted to the activated...
Source: Acta Biomaterialia - May 26, 2009 Category: Materials Science Authors: Jung Kyu Park, Junseok Yeom, Eun Ju Oh, Mallikarjuna Reddy, Jong Young Kim, Dong-Woo Cho, Hyun Pil Lim, Nam Sook Kim, Sang Won Park, Hong-In Shin, Dong Jun Yang, Kwang Bum Park, Sei Kwang Hahn Source Type: journals

Analysis of functionalized polyethylene terephthalate with immobilized NTPDase and cysteineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Polyethylene terephthalate (PET) was functionalized to introduce carboxyl groups onto its surface by a carboxylation technique. Surface and bulk properties, such as possible surface deterioration, surface roughness and the mechanical strength of the carboxylated polymers, were studied and compared with those of aminolyzed and hydrolyzed PET. Atomic force microscopy studies showed that unlike aminolysis and hydrolysis, which increased the surface roughness significantly due to cracking and pitting, the surface roughness of unmodified and carboxylated PET were comparable. While hydrolysis and aminolysis of PET resu...
Source: Acta Biomaterialia - May 26, 2009 Category: Materials Science Authors: Vignesh Muthuvijayan, Jun Gu, Randy S. Lewis Source Type: journals

Chitosan scaffolds incorporating lysozyme into CaP coatings produced by a biomimetic route: A novel concept for tissue engineering combining a self-regulated degradation system with in situ pore formationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study describes an innovative self-regulated degrading material with gradual in situ pore formation ability for bone tissue engineering applications. This approach is based on the incorporation of the lysozyme enzyme into calcium phosphate (CaP) coatings, prepared on the surface of chitosan scaffolds by means of a biomimetic coating technique with the aim of controlling their degradation rate and subsequent formation of pores. However, because lysozyme has antibacterial properties, these coatings may act as a carrier for its sustained release, preventing infection upon implantation. In order to prove the concept of in...
Source: Acta Biomaterialia - May 26, 2009 Category: Materials Science Authors: Ana M. Martins, Rui C. Pereira, Isabel B. Leonor, Helena S. Azevedo, Rui L. Reis Source Type: journals

Interrelationship of micromechanics and morphology of fibroblasts adhered on different polymeric surfacesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The membrane stiffness (ε) of rat lung fibroblasts (RLFs) adhered on different polymeric surfaces was probed by atomic force microscopy. The corresponding cell morphology was also analyzed to probe its interrelationship with ε. Two tyrosine-derived polymer families, poly(DTR glutarate)s and poly(DTE-co-PEG1000 carbonate)s with systematic variations in the chemical composition and physical properties, notably surface hydrophilicity, were used. The cell membrane of adhered RLFs was indented by a probe tip. ε was obtained by best-fitting the relationship of applied tip forces and the indentation depth with the He...
Source: Acta Biomaterialia - May 26, 2009 Category: Materials Science Authors: P. Sidney Sit, Joachim Kohn Source Type: journals

Cyclo-DfKRG peptide modulates in vitro and in vivo behavior of human osteoprogenitor cells on titanium alloysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The first aim of the present study was to investigate the capacity of a cyclo-DfKRG-coated hydroxyapatite–titanium alloy (Ti–HA–RGD) to activate in vitro human osteoprogenitor cells adhesion and differentiation. The second purpose was to examine in vivo the role of a autologous cell seeding on cyclo-DfKRG-functionalized materials to provide bone repair after implantation in femoral condyle of rabbits.Our in vitro results have demonstrated that both titanium alloy functionalized with hydroxyapatite (Ti–HA–RGD and Ti–HA) contributed to higher cell adhesion than titanium alloy alone respectively 85 and 5...
Source: Acta Biomaterialia - May 24, 2009 Category: Materials Science Authors: S. Pallu, J.C. Fricain, R. Bareille, C. Bourget, M. Dard, A. Sewing, J. Amédée Source Type: journals

A physical approach to modify the hydraulic reactivity of α-tricalcium phosphate powderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A microsized α-tricalcium phosphate (α-TCP) powder was calcined at various temperatures (350°C (Source: Acta Biomaterialia)
Source: Acta Biomaterialia - May 24, 2009 Category: Materials Science Authors: Marc Bohner, Reto Luginbühl, Christian Reber, Nicola Doebelin, Gamal Baroud, Egle Conforto Source Type: journals

Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL–PEG–PCL hydrogel. Part 2: Sol–gel–sol transition and drug delivery behaviorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In this work, a biodegradable and injectable in situ gel-forming controlled drug delivery system based on thermosensitive poly(ε-caprolactone)–poly(ethylene glycol)–poly(ε-caprolactone) (PCEC) hydrogel was studied. The prepared PCEC hydrogel undergoes temperature-dependent sol–gel–sol transition, which is a flowing sol at ambient temperature and turns into a non-flowing gel at around physiological body temperature. Furthermore, the sol–gel phase transition mechanism was investigated using 13C-nuclear magnetic resonance imaging and a laser diffraction particle size analyzer. The in vitro release behavi...
Source: Acta Biomaterialia - May 24, 2009 Category: Materials Science Authors: ChangYang Gong, Shuai Shi, Lan Wu, MaLing Gou, QinQin Yin, QingFa Guo, PengWei Dong, Fan Zhang, Feng Luo, Xia Zhao, YuQuan Wei, ZhiYong Qian Source Type: journals

Development of an electrospun nano-apatite/PCL composite membrane for GTR/GBR applicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrated that an electrospun membrane incorporating nAp is strong, enhances bioactivity and supports osteoblast-like cell proliferation and differentiation. The membrane system can be used as a prototype for the further development of an optimal membrane for clinical use. (Source: Acta Biomaterialia)
Source: Acta Biomaterialia - May 24, 2009 Category: Materials Science Authors: Fang Yang, Sanne K. Both, Xuechao Yang, X. Frank Walboomers, John A. Jansen Source Type: journals

Deposition and investigation of functionally graded calcium phosphate coatings on titaniumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A series of calcium phosphate coatings with graded crystallinity were deposited onto heated titanium substrates using ion beam assisted deposition. The microstructure of the coating was examined using transmission electron microscopy (TEM). The coating thickness was observed to be in a range of 594–694nm. The degree of crystallinity and microstructural grain size of the coating showed a clear decrease with increasing distance from the substrate–coating interface. Fourier transform infrared spectroscopy (FTIR) confirmed the presence of , and X-ray photoelectron spectroscopy (XPS) analysis on the coating top su...
Source: Acta Biomaterialia - May 20, 2009 Category: Materials Science Authors: Xiao Bai, Stefan Sandukas, Mark R. Appleford, Joo L. Ong, Afsaneh Rabiei Source Type: journals

Linker-free covalent attachment of the extracellular matrix protein tropoelastin to a polymer surface for directed cell spreadingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Polymers are used for the fabrication of many prosthetic implants. It is desirable for these polymers to promote biological function by promoting the adhesion, differentiation and viability of cells. Here we have used plasma immersion ion implantation (PIII) treatment of polystyrene to modify the polymer surface, and so modulate the binding of the extracellular matrix protein tropoelastin. PIII treated, but not untreated polystyrene, bound tropoelastin in a sodium dodecyl sulfate (SDS)-resistant manner, consistent with previous enzyme-binding data that demonstrated the capability of these surfaces to covalently a...
Source: Acta Biomaterialia - May 20, 2009 Category: Materials Science Authors: Daniel V. Bax, David R. McKenzie, Anthony S. Weiss, Marcela M.M. Bilek Source Type: journals

Porcine bone marrow stromal cell differentiation on heparin-adsorbed poly(e-caprolactone)–tricalcium phosphate–collagen scaffoldsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We evaluate the potential of heparin as a substrate component for the fabrication of bone tissue engineering constructs using poly(e-caprolactone)–tricalcium phosphate–collagen type I (PCL–TCP–Col) three-dimensional (3-D) scaffolds. First we explored the ability of porcine bone marrow precursor cells (MPCs) to differentiate down both the adipogenic and osteogenic pathways within 2-D culture systems, with positive results confirmed by Oil-Red-O and Alizarin Red staining, respectively. Secondly, we examined the influence of heparin on the interaction and behaviour of MPCs when seeded onto PCL–TCP–Col 3-...
Source: Acta Biomaterialia - May 20, 2009 Category: Materials Science Authors: Zhi Zhen Chum, Maria A. Woodruff, Simon M. Cool, Dietmar W. Hutmacher Source Type: journals

Designing porosity and topography of poly(1,3-trimethylene carbonate) scaffoldsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Using phase separation micromolding (PSμM) we developed porous micro-patterned sheets from amorphous poly(1,3-trimethylene carbonate) (PTMC). The use of these PTMC sheets can be advantageous in tissue engineering applications requiring highly flexible constructs. Addition of poly(ethylene oxide) (PEO) in various amounts to PTMC casting solutions provides PTMC sheets with tailored porosity and pore sizes in the range 2–20μm. The pore-forming effect of PEO during the phase separation process is evaluated and glucose transport measurements show that the pores are highly interconnected. Additionally, tailoring th...
Source: Acta Biomaterialia - May 20, 2009 Category: Materials Science Authors: Bernke J. Papenburg, Sigrid Schüller-Ravoo, Lydia A.M. Bolhuis-Versteeg, Liesbeth Hartsuiker, Dirk W. Grijpma, Jan Feijen, Matthias Wessling, Dimitrios Stamatialis Source Type: journals

Chitosan–gelatin scaffolds for tissue engineering: Physico-chemical properties and biological response of buffalo embryonic stem cells and transfectant of GFP–buffalo embryonic stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The favorable cellular response of newly developed cell line, buffalo embryonic stem (ES) cells to three-dimensional biodegradable chitosan–gelatin composite scaffolds with regard to stem-cell-based tissue engineering is described. Chitosan–gelatin composites were characterized by a highly porous structure with interconnected pores, and the mechanical properties were significantly enhanced. Furthermore, X-ray diffraction study indicated increased amorphous content in the scaffold on the addition of gelatin to chitosan. To develop a transfectant of green fluorescence protein (GFP)–buffalo ES cell, transfecti...
Source: Acta Biomaterialia - May 19, 2009 Category: Materials Science Authors: W.W. Thein-Han, J. Saikhun, C. Pholpramoo, R.D.K. Misra, Y. Kitiyanant Source Type: journals

Effect of soft segment crystallization and hard segment physical crosslink on shape memory function in antibacterial segmented polyurethane ionomersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Shape memory polyurethane (SMPU) ionomers containing constant 75wt.% soft segment content were synthesized using poly(ε-caprolactone)diol, 4,4′-diphenylmethane diisocyanate, 1,4-butanediol and/or N,N-bis(2-hydroxyethyl)-isonicotinamide. To introduce substrate bonding antibacterial activity, pyridinium was prepared through a neutralization reaction using 1-iodooctane as neutralization agent. For the SMPU ionomer film obtained, tensile testing at 70°C and dynamic mechanical analysis suggests that, at temperatures>Tms (the melting point of soft segments), 6.72 and 29.55mol.% pyridinium within hard segments signi...
Source: Acta Biomaterialia - May 19, 2009 Category: Materials Science Authors: Y. Zhu, J. Hu, K. Yeung Source Type: journals

Influence of ECM proteins and their analogs on cells cultured on 2-D hydrogels for cardiac muscle tissue engineeringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study assessed the role of immobilized cell adhesion moieties on controlling the cellular attachment, adhesion and phenotype of cardiac muscle cells towards developing scaffolds for cardiac muscle tissue engineering. Collagen I, laminin and the cell-adhesive oligopeptide, arginine-glycine-aspartic acid (RGD) at concentrations of 0.5 and 5mM were covalently bound to flexible two-dimensional hydrogels. A robust skeletal myoblast cell line demonstrated good bioactivity for the modified hydrogels, resulting in myoblast attachment and development of an intracellular contractile network after 1 day. Primary neonatal rat ven...
Source: Acta Biomaterialia - May 18, 2009 Category: Materials Science Authors: Stephanie M. LaNasa, Stephanie J. Bryant Source Type: journals

In vitro antibacterial activity of porous TiO2–Ag composite layers against methicillin-resistant Staphylococcus aureusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The aim of this study was the synthesis of a porous TiO2-Ag composite coating and assessment of its in vitro bactericidal activity against methicillin-resistant Staphylococcus aureus. The coating was produced by plasma electrolytic oxidation of Ti–6Al–7Nb medical alloy in a calcium acetate/calcium glycerophosphate electrolyte bearing Ag nanoparticles. Following oxidation, the surface of the titanium substrate was converted into the corresponding oxide (TiO2) bearing Ca and P species from the electrolyte. In addition, Ag was detected associated with particles present in the oxide layers. The coatings revealed ...
Source: Acta Biomaterialia - May 17, 2009 Category: Materials Science Authors: Bogdan S. Necula, Lidy E. Fratila-Apachitei, Sebastian A.J. Zaat, Iulian Apachitei, Jurek Duszczyk Source Type: journals

Evaluation of the mechanical properties of rat bone under simulated microgravity using nanoindentationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Exposure to microgravity causes a decrease in bone mass and altered bone geometry due to the lack of weight-bearing forces on the skeleton. The mechanical properties of bone are due not only to the structure and geometry, but also to the tissue properties of the bone material itself. To study the effects of microgravity on bone tissue, the mechanical properties of tail suspension rat femurs were investigated. Twelve Sprague–Dawley rats were randomly divided into two groups, tail suspension (TS) and control (CON). On days 0 and 14, the bone mineral density (BMD) of the femurs was determined by Dual Energy X-ray ...
Source: Acta Biomaterialia - May 17, 2009 Category: Materials Science Authors: Lian-wen Sun, Yu-bo Fan, De-yu Li, Feng Zhao, Tian Xie, Xiao Yang, Zhang-ting Gu Source Type: journals

Improved bone-forming functionality on diameter-controlled TiO2 nanotube surfaceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The titanium dioxide (TiO2) nanotube surface enables significantly accelerated osteoblast adhesion and exhibits strong bonding with bone. We prepared various sizes (30–100nm diameter) of titanium dioxide (TiO2) nanotubes on titanium substrates by anodization and investigated the osteoblast cellular behavior in response to these different nanotube sizes. The unique and striking result of this study is that a change in osteoblast behavior is obtained in a relatively narrow range of nanotube dimensions, with small diameter (∼30nm) nanotubes promoting the highest degree of osteoblast adhesion, while larger diamet...
Source: Acta Biomaterialia - May 17, 2009 Category: Materials Science Authors: Karla S. Brammer, Seunghan Oh, Christine J. Cobb, Lars M. Bjursten, Henri van der Heyde, Sungho Jin Source Type: journals

A quantitative in vitro method to predict the adhesion lifetime of diamond-like carbon thin films on biomedical implantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A quantitative method using Rockwell C indentation was developed to study the adhesion of diamond-like carbon (DLC) protective coatings to the CoCrMo biomedical implant alloy when immersed in phosphate-buffered saline (PBS) solution at 37°C. Two kinds of coatings with thicknesses ranging from 0.5 up to 16 microns were investigated, namely DLC and DLC/Si-DLC, where Si-DLC denotes a 90nm thick DLC interlayer containing Si. The time-dependent delamination of the coating around the indentation was quantified by means of optical investigations of the advancing crack front and calculations of the induced stress using ...
Source: Acta Biomaterialia - May 17, 2009 Category: Materials Science Authors: Claudiu Valentin Falub, Götz Thorwarth, Christian Affolter, Ulrich Müller, Cyril Voisard, Roland Hauert Source Type: journals

Electrospun nanostructured scaffolds for bone tissue engineeringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The current challenge in bone tissue engineering is to fabricate a bioartificial bone graft mimicking the extracellular matrix (ECM) with effective bone mineralization, resulting in the regeneration of fractured or diseased bones. Biocomposite polymeric nanofibers containing nanohydroxyapatite (HA) fabricated by electrospinning could be promising scaffolds for bone tissue engineering. Nanofibrous scaffolds of poly-l-lactide (PLLA, 860±110nm), PLLA/HA (845±140nm) and PLLA/collagen/HA (310±125nm) were fabricated, and the morphology, chemical and mechanical characterization of the nanofibers were evaluated using ...
Source: Acta Biomaterialia - May 17, 2009 Category: Materials Science Authors: Molamma P. Prabhakaran, J. Venugopal, S. Ramakrishna Source Type: journals

Titanium implants alter endothelial function and vasoconstriction via a protein kinase C-regulated pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study the maximal contractile responses elicited by phenylephrine in the aortas of rats 4weeks after Ti alloy implantation and in cultured rat aortas treated with a soluble form of Ti for a period of 18h were significantly decreased as compared with controls. Aortas isolated from rats with Ti alloy implants or aortas treated with a soluble form of Ti had enhanced protein expression of endothelial nitric oxide synthase (eNOS) and protein kinase C (PKC)-α and enhanced phosphorylation of extracellular signal-regulated kinase (ERK) 1/2. Treatment of human umbilical vein endothelial cells (HUVECs) with a soluble form o...
Source: Acta Biomaterialia - May 13, 2009 Category: Materials Science Authors: Rong Sen Yang, Huei Ping Tzeng, Feng Ming Ho, Chia Chi Chuang, Bo Lin Chen, Chun-Fa Huang, Ya-Wen Chen, Ruei Ming Chen, Shing Hwa Liu Source Type: journals

Mechanical and in vitro biological performances of hydroxyapatite–carbon nanotube composite coatings deposited on Ti by aerosol depositionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Hydroxyapatite (HA)–carbon nanotube (CNT) composite coatings on Ti plate, produced by aerosol deposition using HA–CNT powders, were developed for biomedical applications. For the deposition process HA–CNT powder mixtures with CNT contents of 1 and 3wt.% were used. Dense coatings with a thickness of 5μm were fabricated, irrespective of the content of CNTs. No pores or microcracks were observed in the coatings. The coatings had good adhesion to the substrate, exhibiting a high adhesion strength, ranging from 27.3 to 29.0MPa. Microstructural observation using field-emission gun scanning electron microscopy an...
Source: Acta Biomaterialia - May 13, 2009 Category: Materials Science Authors: Byung-Dong Hahn, Jung-Min Lee, Dong-Soo Park, Jong-Jin Choi, Jungho Ryu, Woon-Ha Yoon, Byoung-Kuk Lee, Du-Sik Shin, Hyoun-Ee Kim Source Type: journals

Photopatterned collagen–hyaluronic acid interpenetrating polymer network hydrogelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: To engineer complex tissues, it is necessary to create hybrid scaffolds with micropatterned structural and biomechanical properties, which can closely mimic the intricate body tissues. The current report describes the synthesis of a novel photocrosslinkable interpenetrating polymeric network (IPN) of collagen and hyaluronic acid (HA) with precisely controlled structural and biomechanical properties. Both collagen and HA are present in crosslinked form in IPNs, and the two networks are entangled with each other. IPNs were also compared with semi-IPNs (SIPN), in which only collagen was in network form and HA chains...
Source: Acta Biomaterialia - May 13, 2009 Category: Materials Science Authors: Shalu Suri, Christine E. Schmidt Source Type: journals

Fluorescent mesoporous silica nanotubes incorporating CdS quantum dots for controlled release of ibuprofenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Mesoporous silica nanotubes (MSNTs) and amine-functionalized MSNTs (NH2-MSNTs) have been successfully synthesized via a sol–gel route using needle-like CaCO3 nanoparticles as inorganic templates and post-modification with 3-aminopropyltriethoxysilane. Subsequently, the preformed nanotubes were functionalized with blue fluorescent CdS quantum dots, as demonstrated by transmission electron microscopy and confocal laser scanning microscopy. The morphology and microstructure of the produced materials were characterized by scanning electron microscopy and N2 adsorption–desorption measurements. A comparative study ...
Source: Acta Biomaterialia - May 12, 2009 Category: Materials Science Authors: Yun-Jie Yang, Xia Tao, Qian Hou, Jian-Feng Chen Source Type: journals

Nanohydroxyapatite/poly(ester urethane) scaffold for bone tissue engineeringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the preparation of hydroxyapatite nanoparticles (nHA)/poly(ester urethane) composite scaffolds using a salt-leaching-phase inverse process is reported. The dispersion of nHA microaggregates in the polymer matrix were imaged by microcomputed X-ray tomography, allowing a study of the effect of the nHA mass fraction and process parameters on the inorganic phase dispersion, and ultimately the optimization of the preparation method. How the composite scaffold’s geometry and mechanical properties change with the nHA mass fraction and the process parameters were assessed. Increasing the amount of nHA particles in...
Source: Acta Biomaterialia - May 12, 2009 Category: Materials Science Authors: C.I.R. Boissard, P.-E. Bourban, A.E. Tami, M. Alini, D. Eglin Source Type: journals

Sonochemically prepared BSA microspheres containing Gemcitabine, and their potential application in renal cancer therapeuticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report demonstrates the formation and characterization of sonochemically prepared bovine serum albumin (BSA)–Gemzar (Gemcitabine) microspheres and shows their increased anticancer activity compared to pristine Gemzar. The amount of loaded Gemzar was determined by light absorption measurements. The BSA–Gemzar composite was analyzed and characterized by optical microscopy and scanning electron microscopy. The release kinetics of Gemzar from the proteinaceous microspheres was tested. The BSA–Gemzar composite was examined for its anticancer activity (in vitro) in renal cancer cells (RCC, 786-O cells) using [3H]thymi...
Source: Acta Biomaterialia - May 12, 2009 Category: Materials Science Authors: Olga Grinberg, Aharon Gedanken, Chitta Ranjan Patra, Sujata Patra, Priyabrata Mukherjee, Debabrata Mukhopadhyay Source Type: journals