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Erratum to: Prevalence and correlates of inadequate glycaemic control: results from a nationwide survey in 6,671 adults with diabetes in Brazil.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19787292 [PubMed - as supplied by publisher]
Source: Acta Diabetol AND (h... - September 29, 2009 Category: Endocrinology Authors: Mendes AB, Fittipaldi JA, Neves RC, Ch...a AR, Moreira ED Tags: Acta Diabetol Source Type: journals

DNA damage evaluated by comet assay in Mexican patients with type 2 diabetes mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, given that general DNA damage was similar in the three groups of patients with DM2 and the control group, it is possible that these cells showed similar oxidative damage, as has been proposed previously. PMID: 19787291 [PubMed - as supplied by publisher]
Source: Acta Diabetol AND (h... - September 29, 2009 Category: Endocrinology Authors: Ibarra-Costilla E, Cerda-Flores RM, Dávila-Rodríguez MI, Samayo-Reyes A, Calzado-Flores C, Cortés-Gutiérrez EI Tags: Acta Diabetol Source Type: journals

Effect of pioglitazone on systemic inflammation is independent of metabolic control and cardiac autonomic function in patients with type 2 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this article is to investigate the relation of the anti-inflammatory effect of pioglitazone with cardiac autonomic function and metabolic control in diabetic patients. In this prospective open label trial, 36 type 2 diabetic patients (age 60 +/- 10, 20 M) without overt cardiovascular disease were randomized to add pioglitazone (30 mg) to their therapy or to continue standard therapy. C-reactive protein (CRP) serum levels, metabolic parameters and cardiac autonomic function (assessed by heart rate variability [HRV] on 24-h ECG Holter monitoring) were measured at baseline and after 3 months. Clinical and labor...
Source: Acta Diabetol AND (h... - September 29, 2009 Category: Endocrinology Authors: Nerla R, Pitocco D, Zaccardi F, Scalone G, Coviello I, Mollo R, Gh...ANDa G, Lanza GA, Crea F Tags: Acta Diabetol Source Type: journals

Excessive maternal transmission of diabetes in Japanese families with young-onset type 2 diabetes and insulin secretion defect according to clinical features.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the study is to identify the clinical characteristics of Japanese patients with young-onset type 2 diabetes (YT2D). Family history of diabetes and clinical data were collected for 30 unrelated males (from 11 to 20 years old at age of onset) and 20 females (from 10 to 20 years old at age of onset) with YT2D diagnosed at </=20 years of age. Fasting C-peptide levels were measured in all, and glucagon stimulation tests were performed twice in six of them over several years. Moreover, 858 people with type 2 diabetes (T2D) diagnosed at >20 years of age were randomly recruited in order to compare the transmis...
Source: Acta Diabetol AND (h... - September 29, 2009 Category: Endocrinology Authors: Otabe S, Nakayama h...ukutani T, Yuan X, Wada N, h...inaga T, Mitsui A, Kato T, Inada C, Tajiri Y, Yamada K Tags: Acta Diabetol Source Type: journals

The relationship between coronary artery calcification score, plasma osteoprotegerin level and arterial stiffness in asymptomatic type 2 DM.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Because T2DM increases the risk of coronary atherosclerosis and CAD and new noninvasive techniques to assess CVD risk have gained considerable popularity, it is important to know how these tools relate to each other. The aim of this study was to evaluate the relationship between the extent of coronary artery calcification measured by MDCT, plasma OPG levels, baPWV and the established cardiovascular risk factors in Korean patients with T2DM. From November 2006 to December 2007, 110 asymptomatic Korean patients with T2DM without prior evidence of CAD were assessed (mean age 57.2 years). CAC imaging was performed using a ...
Source: Acta Diabetol AND (h... - September 29, 2009 Category: Endocrinology Authors: Jung Ch...ee WY, Kim SY, Jung Jh...h...EJ, Park CY, Mok JO, Oh..., Kim Ch...ark SW, Kim SW Tags: Acta Diabetol Source Type: journals

Low serum osteoprotegerin levels in normoalbuminuric type 1 diabetes mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study is to establish whether abnormal mineral metabolism is present in patients with type 1 DM with normal renal function and in the absence of microalbuminuria. Serum levels of 1,25-dihydroxyvitamin D, osteoprotegerin (OPG) and receptor activator for nuclear factor kappa beta ligand (RANKL) and other determinants of bone metabolism were measured in 35 patients with type 1 DM and in 25 age-, sex- and ethnicity-matched healthy controls. Serum OPG (1.98 vs. 2.98 pmol/l: P = 0.001), 1,25-dihydroxyvitamin D (41.1 vs. 48.2 pmol/l: P = 0.035) and magnesium (0.84 vs. 0.89 mmol/l P = 0.029) levels were signifi...
Source: Acta Diabetol AND (h... - September 26, 2009 Category: Endocrinology Authors: Singh..., Winocour P, Summerh...s B, Viljoen A, Sivakumar G, Farrington K Tags: Acta Diabetol Source Type: journals

Middle age is not associated with altered fibrinogen concentration and production in males.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Whether ageing is associated with increased fibrinogen concentration and production remains unclear. We measured fibrinogen fractional (FSR) and absolute synthesis (ASR) rates in male volunteers, of either young (mean age: 28 years, range: 22-34) or middle age (mean age: 57 years, range: 38-72), using a leucine-tracer isotope dilution technique. In the middle-age group, neither fibrinogen FSR (20.8 +/- 1.6%/day) nor ASR (1.8 +/- 0.1 g/day), or concentration (274 +/- 15 mg/dl), were different from those of the younger group (FSR: 20.2 +/- 1.4; ASR: 1.7 +/- 0.2; concentration: 265 +/- 8, respectively). Leucine Ra, an ind...
Source: Acta Diabetol AND (h... - September 23, 2009 Category: Endocrinology Authors: Tessari P, Millioni R, Vettore M, Cecch...D, Puricelli L Tags: Acta Diabetol Source Type: journals

Are measures of height and leg length related to incident diabetes mellitus? The ARIC (Atherosclerosis Risk in Communities) study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to estimate the risk of developing diabetes in relation to adult height components, namely leg length and leg length/height ratio. Data on 12,800 individuals without diabetes were obtained at the baseline examination from the ARIC cohort. Cox proportional hazard models were used to estimate hazard rate ratios of diabetes for each 5-cm difference in leg length and 1 SD difference in the leg length/height ratio. During a mean follow-up period of 7.6 years, the age-adjusted incidence per 1,000 person years of follow-up was 25.8, 24.2, 10.4, and 16.2 in African American (AA) women, AA men, white women, ...
Source: Acta Diabetol AND (h... - September 23, 2009 Category: Endocrinology Authors: Weitzman S, Wang Ch...ankow JS, Sch...t MI, Brancati FL Tags: Acta Diabetol Source Type: journals

Insulin-like growth factor binding protein: a possible marker for the metabolic syndrome?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Insulin-like growth factor (IGF) binding proteins (IGFBPs) moved on to contain both IGF high- and low-affinity binders, exerting mitogenic and metabolic actions through its complex interplay between IGF/insulin and its IGF/insulin-independent manner. Progress on the metabolic-related function of IGFBPs has been rapid in recent years. A wealth of studies in 3T3-L1 adipocytes and the transgenic mice models demonstrated that IGFBPs played important roles in the pathogenesis of obesity and insulin resistance. Studies conducted in humans demonstrated the close relation between IGFBPs and the components of the metabolic synd...
Source: Acta Diabetol AND (h... - September 22, 2009 Category: Endocrinology Authors: Ruan W, Lai M Tags: Acta Diabetol Source Type: journals

Combined use of fasting plasma glucose and glycated hemoglobin A1c in the screening of diabetes and impaired glucose tolerance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study is to assess the validity of combined use of fasting plasma glucose (FPG) and glycated hemoglobin A1c (HbA1c) as screening tests for diabetes and impaired glucose tolerance (IGT) in high-risk subjects. A total of 2,298 subjects were included. All subjects underwent a 75-g oral glucose tolerance test (OGTT) and HbA1c measurement. Receiver operating characteristic curve (ROC curve) analysis was used to examine the sensitivity and specificity of FPG and HbA1c for detecting diabetes and IGT, which was defined according to the 1999 World Health Organization (WHO) criteria. (1) Based on the ROC curve, t...
Source: Acta Diabetol AND (h... - September 17, 2009 Category: Endocrinology Authors: h..., Liu W, Ch...Y, Zh... M, Wang L, Zh...h...u P, Teng X, Dong Y, Zh...JW, Xu h...h... J, Li S, Tao T, h..., Jia Y Tags: Acta Diabetol Source Type: journals

Insulin analogs and pregnancy: an update.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is well known that good metabolic control maintained throughout pregnancy reduces maternal and fetal complications in diabetes. Before conception and throughout pregnancy, insulin therapy needs to be optimized and, in this context, the insulin analogs currently available in the market may help to achieve good metabolic control. We therefore review here what is known about the potential benefits and risks related to the use of these new insulins in pregnancy. Clinical and experimental data on insulin aspart and lispro strongly suggest that they have no adverse maternal or fetal effects during pregnancy in women with ...
Source: Acta Diabetol AND (h... - September 1, 2009 Category: Endocrinology Authors: Torlone E, Di Cianni G, Mannino D, Lapolla A Tags: Acta Diabetol Source Type: journals

Metabolic syndrome is independently associated with microalbuminuria in type 2 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19707713 [PubMed - as supplied by publisher]
Source: Acta Diabetol AND (h... - August 26, 2009 Category: Endocrinology Authors: Estegh...ti A, Rash... A, Kh...lzadeh... Ash... h...bbasi M Tags: Acta Diabetol Source Type: journals

Computation of the excess glucose and Na deficit of hypo-osmolar hyponatremic hyperglycaemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exact computations of glucose accumulation (GA, mM) and Na anions deficit (DeltaNa, mEq) can be obtained in hypo-osmolar hyponatremic hyperglycaemia (HHH), where plasma osmolality (POsm) is lower than normal. In this condition, GA - DeltaNa = POsm x TBW (total body water). GA is given by plasma glucose concentration (PG(1)) times extra-cellular volume (ECV), calculated as TBW - ICV (the known intra-cellular volume). The changes in solute content can then be computed from their concentrations. This model was verified on computer-simulated patients to whom GA was added in variable amounts, lower than those of DeltaNa sub...
Source: Acta Diabetol AND (h... - August 12, 2009 Category: Endocrinology Authors: Bartoli E, Sainagh...P, Bergamasco L, Castello L Tags: Acta Diabetol Source Type: journals

Prevalence and correlates of inadequate glycaemic control: results from a nationwide survey in 6,671 adults with diabetes in Brazil.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to estimate the prevalence of inadequate glycaemic control and its correlates in a large multicentre survey of Brazilian patients with diabetes. A cross-sectional study was conducted in a consecutive sample of patients aged 18 years or older with either type 1 or type 2 diabetes, attending health centres located in ten large cities in Brazil (response rate = 84%). Information about diabetes, current medications, complications, diet, and satisfaction with treatment were obtained by trained interviewers, using a standardized questionnaire. Glycated haemoglobin (HbA(1c)) was measured by high-performance liqui...
Source: Acta Diabetol AND (h... - August 5, 2009 Category: Endocrinology Authors: Mendes AB, Fittipaldi JA, Neves RC, Ch...a AR, Moreira ED Tags: Acta Diabetol Source Type: journals

Lower BMI cutoff for assessing the prevalence of metabolic syndrome in Thai population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article investigates the prevalence of metabolic syndrome (MS) and the benefits of lowered body mass index (BMI) cutoff point for assessing MS prevalence in a large, nationally representative population sample comprising of 15,365 Thai adults from metropolitan Bangkok who received annual checkup. Prevalence of MS was characterized using the International Diabetes Federation criteria and BMI >/=25 kg/m(2) as cutoff revealed that 26.63% of male and 14.90% of female subjects had MS and the prevalence was age dependent. Traditional BMI cutoff of >/=30 kg/m(2) underestimated MS prevalence in Thai population while BMI...
Source: Acta Diabetol AND (h... - August 1, 2009 Category: Endocrinology Authors: Worach...ch...an A, Nantasenamat C, Isarankura-Na-Ayudh...C, Pidetch..., Prach...sittikul V Tags: Acta Diabetol Source Type: journals

Maternal physical activity before and during early pregnancy as a risk factor for gestational diabetes mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to assess whether the levels of physical activity before and during early pregnancy are associated with the prevalence of gestational diabetes mellitus (GDM). The study group included 160 puerperas. Among them, 40 (25%) diagnosed as having GDM during their recent pregnancy, whereas the remaining 120 (75%) served as controls. The international physical activity questionnaire (IPAQ-Greek version) was applied twice, in an attempt to estimate the level of physical activity before and during early pregnancy. Women who were "inactive" before or during early pregnancy had odds ratio (OR) 7.9 [95% con...
Source: Acta Diabetol AND (h... - July 18, 2009 Category: Endocrinology Authors: h...zopoulou VC, Kritikos A, Papanikolaou Z, Saranti E, Vavilis D, Klonos E, Papadimas I, Goulis DG Tags: Acta Diabetol Source Type: journals

Animal insulin therapy induces a biased insulin antibody response that persists for years after introduction of human insulin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigates the parameters affecting IA frequency and binding levels in a cohort of type 1 diabetes (T1D) patients. All patients were treated with human recombinant insulin. About half of the patients had received animal insulin prior to the introduction of human recombinant insulin. We tested the IA frequency and binding level for all serum samples. IA were further analyzed for their epitope specificity comparing human and porcine insulin binding. We found that T1D patients who received animal insulin in the past show significantly higher IA binding levels as compared to patients treated exclusively with human...
Source: Acta Diabetol AND (h... - June 23, 2009 Category: Endocrinology Authors: Oak S, Ph...Th...illiam LK, h...ch..., h...e CS Tags: Acta Diabetol Source Type: journals

Is the current therapeutic armamentarium in diabetes enough to control the epidemic and its consequences? What are the current shortcomings?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The prevalence of diabetes is expected to rise together with an increase in morbidity and a reduction in life expectancy. A leading cause of death is cardiovascular disease, and hypertension and diabetes are additive risk factors for this complication. Selected treatment options should neither increase cardiovascular risk in patients with diabetes, nor increase risk of hyperglycaemia in patients with hypertension. The efficacy of present antihyperglycaemic agents is limited and new therapies, such as incretin-targeted agents, are under development. Even though most patients do not achieve glycated haemoglobin targets, ...
Source: Acta Diabetol AND (h... - June 20, 2009 Category: Endocrinology Authors: Giugliano D, StANDl E, Vilsbøll T, Betteridge J, Bonadonna R, Campbell IW, Sch...th...r Gh...taels B, Trich...ulou A, Farinaro E Tags: Acta Diabetol Source Type: journals

Transcription factor 7-like 2-gene polymorphism is related to fasting C peptide in latent autoimmune diabetes in adults (LADA).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the data from this study confirmed previous results showing genetic similarities between patients with LADA and type 2 diabetes. Non-autoimmune mechanism may be related to beta cell dysfunction in patients with LADA. PMID: 19533015 [PubMed - as supplied by publisher]
Source: Acta Diabetol AND (h... - June 17, 2009 Category: Endocrinology Authors: Szepietowska B, Moczulski D, Wawrusiewicz-Kurylonek N, Grzeszczak W, Gorska M, Szelach...ka M Tags: Acta Diabetol Source Type: journals

Continuous subcutaneous insulin infusion versus multiple daily insulin injections in type 1 diabetes: a meta-analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Continuous subcutaneous insulin infusion (CSII) is considered an option for type 1 diabetic patients unsatisfactorily controlled with multiple daily injections (MDI). Short-acting analogs are superior to regular human insulin in CSII. This meta-analysis is aimed at assessing the advantages of short-acting analog-based CSII over MDI in type 1 diabetes. Randomized clinical trials (RCTs) comparing CSII (with analogs) and MDI for at least 12 weeks in type 1 diabetic patients were retrieved, assessing between-group differences in HbA1c and incidence of hypoglycemia. A total of 11 RCTs was included in the analysis. CSII was ...
Source: Acta Diabetol AND (h... - June 6, 2009 Category: Endocrinology Authors: Monami M, Lamanna C, March...ni N, Mannucci E Tags: Acta Diabetol Source Type: journals

Exercise for the management of type 2 diabetes: a review of the evidence.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim is to critically review the more relevant evidence on the interrelationships between exercise and metabolic outcomes. The research questions addressed in the recent specific literature with the most relevant randomized controlled trials, meta-analysis and cohort studies are presented in three domains: aerobic exercise, resistance exercise, combined aerobic and resistance exercise. From this review appear that the effects of aerobic exercise are well established, and interventions with more vigorous aerobic exercise programs resulted in greater reductions in HbA(1c), greater increase in VO(2max) and greater incr...
Source: Acta Diabetol AND (h... - June 3, 2009 Category: Endocrinology Authors: Zanuso S, Jimenez A, Pugliese G, Corigliano G, Balducci S Tags: Acta Diabetol Source Type: journals

Exercise therapy in Type 2 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Structured exercise is considered an important cornerstone to achieve good glycemic control and improve cardiovascular risk profile in Type 2 diabetes. Current clinical guidelines acknowledge the therapeutic strength of exercise intervention. This paper reviews the wide pathophysiological problems associated with Type 2 diabetes and discusses the benefits of exercise therapy on phenotype characteristics, glycemic control and cardiovascular risk profile in Type 2 diabetes patients. Based on the currently available literature, it is concluded that Type 2 diabetes patients should be stimulated to participate in specifical...
Source: Acta Diabetol AND (h... - May 29, 2009 Category: Endocrinology Authors: Praet SF, van Loon LJ Tags: Acta Diabetol Source Type: journals

Metabolic syndrome is independently associated with microalbuminuria in type 2 diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, MetS is independently associated with microalbuminuria in type 2 diabetes. PMID: 19479185 [PubMed - as supplied by publisher]
Source: Acta Diabetol AND (h... - May 29, 2009 Category: Endocrinology Authors: Estegh...ti A, Rash... A, Kh...lzedeh... Ash... h...bbasi M Tags: Acta Diabetol Source Type: journals

The oxidative stress status in diabetes mellitus and diabetic nephropathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study is to assess the oxidative stress status in diabetes mellitus (DM) and diabetic nephropathy. The study group comprised 40 control subjects, 40 type 2 DM patients without complications and 37 diabetic nephropathies. Compared with control subjects, superoxide dismutase, glutathione peroxidase, catalase, vitamin C were decreased (P < 0.01). There was a significant increase in serum malondialdehyde (MDA), conjugated diene (CD), advanced oxidation protein products (AOPP), protein carbonyl (PC) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in diabetes patients when compared with normal subjects (P < 0....
Source: Acta Diabetol AND (h... - May 28, 2009 Category: Endocrinology Authors: Pan h...Zh... L, Guo MY, Sui h...i h...u Wh...u NQ, Liang Mh...h... D Tags: Acta Diabetol Source Type: journals

Circulating vascular endothelial growth factor in the normo- and/or microalbuminuric patients with type 2 diabetes mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Relationship between serum vascular endothelial growth factor (VEGF) level and parameters of endothelial injury and/or dysfunction in patients with diabetes mellitus type 2 with or without microalbuminuria was investigated. Eighty-four diabetic patients were divided in two subgroups (42 each): normoalbuminuric (NAU) and microalbuminuric (MAU). Forty-two blood donors were in control group. Serum VEGF and plasma von Willebrand factor, soluble thrombomodulin, plasminogen activator inhibitor 1, thrombin-activatable fibrinolysis inhibitor (TAFI) and tissue plasminogen activator (t-PA) were measured using enzyme-linked immun...
Source: Acta Diabetol AND (h... - May 13, 2009 Category: Endocrinology Authors: Kubisz P, Ch...#xFD; P, Staško J, Galajda P, h...ý P, Vyšeh...ský R, Mokáň M Tags: Acta Diabetol Source Type: journals

Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, serum CRP level is significantly associated with obesity, especially the visceral adipose tissue, and serum leptin is another important independent factor associated with CRP in Korean type 2 diabetic patients. PMID: 19415164 [PubMed - as supplied by publisher]
Source: Acta Diabetol AND (h... - May 5, 2009 Category: Endocrinology Authors: Park JS, Ch...h...am JS, Ah...W, Ch...S, Lee EJ, Lim SK, Kim KR, Lee HC Tags: Acta Diabetol Source Type: journals

Analysis of the membrane fluidity of erythrocyte ghosts in diabetic, spontaneously hypertensive rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diabetes and hypertension are closely related diseases associated with changes in membrane fluidity. Here, we measured the membrane fluidity of erythrocyte ghosts from spontaneously hypertensive rats (SHR), with or without streptozotocin (STZ)-induced diabetes, at the ages of 1, 3 and 6 months, by introducing the use of the intramolecular excimer forming dipyrenylpropane (DPyP) in this model. Type 2 diabetes mellitus (T2DM) was induced in 48-h-old, newborn male SHR by intraperitoneal injection of STZ. We found lower excimer to monomer (I (e)/I (m)) DPyP ratios in diabetic SHR than in control SHR at 3 and 6 months old, ...
Source: Acta Diabetol AND (h... - April 29, 2009 Category: Endocrinology Authors: Pérez-h...ández Ih...vendaño-Flores YS, Mejía-Zepeda R Tags: Acta Diabetol Source Type: journals

How increased VEGF induces glomerular hyperpermeability: a potential signaling pathway of Rac1 activation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite growing evidence for a pathogenic role of vascular endothelial growth factor (VEGF) in microvascular complications of diabetes, the underlying mechanism responsible for its detrimental effect remains unknown. In the current study, we hypothesized that some of the detrimental effects of VEGF on microvascular endothelial cells in the diabetic milieu stem from its aberrant signaling, which leads to perturbed tight junction assembly and increased endothelial permeability. Using an integrated in vitro approach, we investigated whether the effect of VEGF on endothelial cell permeability involves Rac1 GTPase activatio...
Source: Acta Diabetol AND (h... - April 29, 2009 Category: Endocrinology Authors: Peng h...ang C, Ye ZC, Ch...YR, Zh... J, Ch...ZJ, Yu XQ, Lou TQ Tags: Acta Diabetol Source Type: journals

Influence of iron metabolism indices on glycated haemoglobin but not glycated albumin levels in premenopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusions, iron metabolism indices influence HbA(1C) levels, but not serum GA levels, in premenopausal women. PMID: 19404566 [PubMed - as supplied by publisher]
Source: Acta Diabetol AND (h... - April 29, 2009 Category: Endocrinology Authors: Koga M, Saito h...ukai M, Matsumoto S, Kasayama S Tags: Acta Diabetol Source Type: journals

Effects of high glucose and thiamine on the balance between matrix metalloproteinases and their tissue inhibitors in vascular cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We reported on reduced pericyte adhesion to high glucose-conditioned ECM and correction by thiamine. We aimed at verifying the effects of thiamine and benfotiamine on MMP-2, MMP-9 and TIMP expression and activity in human vascular cells with high glucose. In HRP, MMP-2 activity, though not expression, increased with high glucose and decreased with thiamine and benfotiamine; TIMP-1 expression increased with high glucose plus thiamine and benfotiamine; MMP-9 was not expressed. In EC, MMP-9 and MMP-2 expression and activity increased with high glucose, but thiamine and benfotiamine had no effects; TIMP-1 expression was unchan...
Source: Acta Diabetol AND (h... - April 29, 2009 Category: Endocrinology Authors: Tarallo S, Beltramo E, Berrone E, Dentelli P, Porta M Tags: Acta Diabetol Source Type: journals

Glucose levels during oral glucose tolerance tests and gamma-glutamyl transpeptidase are predictors of change from normal to impaired glucose tolerance in healthy middle-aged Japanese men.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We evaluated the predictors of the development from normal to impaired glucose tolerance (IGT) in healthy middle-aged Japanese men. Forty male subjects who showed normal glucose tolerance (NGT) levels based on WHO criteria and who had undergone 75-g OGTT annually for 10 years were selected in the database of medical checkups retrospectively, and divided into two groups: those retaining NGT and those that developed IGT. Gamma-glutamyl transpeptidase (GGT) and the glucose levels at 30 and 60 min were significantly associated with the development of IGT in the Cox proportional hazard model. However, other clinical charact...
Source: Acta Diabetol AND (h... - April 24, 2009 Category: Endocrinology Authors: Watanabe K, Oba K, Suzuki T, Okuyama Y, Ouch..., Suzuki K, Oh...h..., h...imoto M, Igari Y, Nakano H Tags: Acta Diabetol Source Type: journals

Association of homozygous SDF-1 3'A genotype with proliferative diabetic retinopathy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stromal cell-derived factor 1 (SDF-1) is involved in the development of experimental proliferative retinopathy. Since little data are available on the genetic predisposition or on biomarkers predicting the development of proliferative retinopathy, we assessed the distribution of the SDF-1 3'A genotype in 130 diabetic patients with retinopathy. In patients with proliferative retinopathy, the frequency of the homozygous SDF-1 3'A genotype was significantly higher than in patients with non-proliferative retinopathy (10.9% of PDR vs. 0 of NPDR, P = 0.01). This association was confirmed when type 2 diabetes patients were an...
Source: Acta Diabetol AND (h... - April 21, 2009 Category: Endocrinology Authors: Djuric Z, Sh...i V, Rudofsky G, Morcos M, Li h...ammes h...Nawroth..., Bierh... A, h...ert PM, Jonas JB Tags: Acta Diabetol Source Type: journals

Early microvascular complications of prediabetes in mice with impaired glucose tolerance and dyslipidemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Microvascular complications are an important cause of morbidity in diabetic patients and can be detected in a significant number of patients at the time of diabetes diagnosis. However, little is known about the alterations in the microvasculature previous to the clinical manifestation of diabetes mellitus type 2. To obtain more insights into the early microvascular deterioration resulting from prediabetes, morphological and functional microvascular parameters were monitored using intravital fluorescence microscopy through a dorsal skin-fold chamber preparation in the uncoupling promotor-driven diphtheria toxin A chain ...
Source: Acta Diabetol AND (h... - April 15, 2009 Category: Endocrinology Authors: Sch...er C, Biermann T, Sch...der M, Fuh...p I, Niemeier A, Rüth...W, Algenstaedt P, h...en-Algenstaedt N Tags: Acta Diabetol Source Type: journals

Lack of association between TNF 238 G/A polymorphism and type 2 diabetes: a meta-analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this meta-analysis was to determine the nature of the association between TNF 238 G/A polymorphism and the risk for T2D. We searched databases updated on January 2009 for all publications on the association between this variation and T2D. Data on genotypes and the numbers of cases and controls were assessed using Review Manager 4.2. Meta-analysis of the overall and specific populations was conducted, and odds ratios (OR) and 95% confidence intervals (95% CI) were calculated in the fixed-effect model. I (2) statistic was calculated to examine heterogeneity, and publication bias was evaluated by Egger test. Th...
Source: Acta Diabetol AND (h... - April 15, 2009 Category: Endocrinology Authors: Feng R, Li Y, Zh...D, Wang C, Niu Y, Sun C Tags: Acta Diabetol Source Type: journals

TAQIB and I405V polymorphisms of CETP are moderately associated with obesity risk in the Chinese adult population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, less common alleles of TAQIB and I405V appear to be modestly associated with obesity risk in an adult Chinese population. Adjustments for HDL levels completely (TAQIB) or partially (I405V) abolished the observed association. PMID: 19360375 [PubMed - as supplied by publisher]
Source: Acta Diabetol AND (h... - April 10, 2009 Category: Endocrinology Authors: Ruan X, Ma L, Wang S, Lindpaintner K, Liu X, Wang B, Peng Z, Ma X, Ch... M, Zh... J, Liu L, Wang X Tags: Acta Diabetol Source Type: journals

Beneficial effects of astragalus polysaccharides treatment on cardiac chymase activities and cardiomyopathy in diabetic hamsters.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the effects of APS treatment on cardiac function, myocardial collagen expression, cardiac ultrastructure, cardiac matrix metalloproteinase (MMP) activity, levels of plasma glycosylated serum protein (GSP), and myocardial enzymes, and the expression of Ang II, chymase, and angiotensin-converting enzyme (ACE) in the diabetic hamster myocardium. Diabetes was induced by a single injection of streptozotocin (60 mg/kg ip). The experimental groups consisted of normal control (n = 15), diabetic (n = 15), insulin-treated diabetic (n = 15, NPH 1-2 U/day ip), and APS-treated diabetic (n = 30, APS 1-2 g/...
Source: Acta Diabetol AND (h... - April 7, 2009 Category: Endocrinology Authors: Ch...W, Yu Mh...i YM, Ch...WJ, Xia YP Tags: Acta Diabetol Source Type: journals

Hyperglycaemia in critical illness is a risk factor for later development of type II diabetes mellitus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hyperglycaemia caused by stress and inflammation is common during critical illness. We hypothesised that a latent glucose metabolism disturbance contributes to development of hyperglycaemia and that those patients have increased risk for diabetes. We included patients with sepsis, acute coronary syndrome and acute heart failure with no history of impaired glucose metabolism and divided them in the hyperglycaemia group (glucose >/= 7.8 mmol/l) and normoglycaemia group. Patients were followed for 5 years. Follow-up was completed for 115 patients in the normoglycaemia group, of which 4 (3.5%) developed type 2 diabetes....
Source: Acta Diabetol AND (h... - April 2, 2009 Category: Endocrinology Authors: Gornik I, Vujaklija A, Lukić E, Madžarac G, Gašparović V Tags: Acta Diabetol Source Type: journals

Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was to determine whether the damage was correlated with expression of the SARS coronavirus receptor, angiotensin converting enzyme 2 (ACE2), in different organs, especially in the endocrine tissues of the pancreas, and to elucidate the pathogenesis of glucose intolerance in SARS patients. The effect of clinical variables on survival was estimated in 135 SARS patients who died, 385 hospitalized SARS patients who survived, and 19 patients with non-SARS pneumonia. A total of 39 SARS patients who had no previous diabetes and received no steroid treatment were compared to 39 matched healthy siblings during a 3-year f...
Source: Acta Diabetol AND (h... - March 31, 2009 Category: Endocrinology Authors: Yang JK, Lin SS, Ji XJ, Guo LM Tags: Acta Diabetol Source Type: journals

Association of obesity with diabetic retinopathy: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SN-DREAMS Report no. 8).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the study was to report the prevalence of obesity indices in individuals with diabetes and find out their association with diabetic retinopathy in the urban Indian population. Subjects (n = 1,414) were recruited from Sankara Nethralaya Diabetic Retinopathy Epidemiology And Molecular Genetics Study (SN-DREAMS-I), a cross-sectional study between 2003 and 2006. Anthropometric measurements were carried out, and all patients' fundi were photographed using 45 degrees four-field stereoscopic digital photography. The diagnosis of diabetic retinopathy was based on the modified Klein classification. Generalized obesit...
Source: Acta Diabetol AND (h... - March 27, 2009 Category: Endocrinology Authors: Raman R, Rani PK, Gnanamoorth..., Sudh...RR, Kumaramanikavel G, Sh...a T Tags: Acta Diabetol Source Type: journals

Secondary diabetes associated with principal endocrinopathies: the impact of new treatment modalities.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The secondary occurrence of type 2 diabetes with various hormonal diseases (e.g. pituitary, adrenal and/or thyroid diseases) is a recurrent observation. Indeed, impaired glucose tolerance (IGT) and overt diabetes mellitus are frequently associated with acromegaly and hypercortisolism (Cushing syndrome). The increased cardiovascular morbidity and mortality associated with acromegaly and Cushing syndrome may partly be a consequence of increased insulin resistance that normally accompanies hormone excess. Acromegalic patients are insulin resistant, both in the liver and in the periphery, displaying hyperinsulinemia and in...
Source: Acta Diabetol AND (h... - March 26, 2009 Category: Endocrinology Authors: Resmini E, Minuto F, Colao A, Ferone D Tags: Acta Diabetol Source Type: journals

Insulin dose adjustment when changing from multiple daily injections to continuous subcutaneous insulin infusion in the pediatric age group.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study is to determine the proper initial dose adjustment when switching from multiple daily injections to continuous subcutaneous insulin infusion for type-1 diabetic pediatric patients. Our hypothesis is that the insulin adjustment varies depending on the pubertal status and the previous long-acting insulin used. Charts of 60 patients were reviewed. Data regarding insulin dose, type of insulin administrated, HbA1c, BMI, severe hypoglycemia and DKA events were collected during the previous year and after 6 weeks of pump therapy. In the prepubertal patients the reduction was 19% (26% if the previous insu...
Source: Acta Diabetol AND (h... - March 25, 2009 Category: Endocrinology Authors: Colino E, Alvarez MA, Carcavilla A, Alonso M, Ros P, Barrio R Tags: Acta Diabetol Source Type: journals

Prevalence of asthmatic symptoms in Lebanese patients with type 1 diabetes and their unaffected siblings compared to age-matched controls.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with type 1 diabetes (a TH1 disease) have been reported to be at a lower risk of developing asthma (a TH2 disease). Both diseases are affected by environmental and genetic factors. Our objective is to examine this relationship in Lebanon, a Middle-Eastern country, where no previous similar studies are available. This is a cross-sectional observational study conducted at the Chronic Care Center, a referral medical center for type 1 diabetics. Patients with type 1 diabetes aged 6-39 years old, their unaffected siblings and age-matched control completed the International Primary Care Airways Group asthma screenin...
Source: Acta Diabetol AND (h... - March 25, 2009 Category: Endocrinology Authors: Taleb N, Bou Kh...l P, Zantout MS, Zalloua P, Azar ST Tags: Acta Diabetol Source Type: journals

Letter to the Editor re: the Letter to the Editor by Dr. David Samuel Henry Bell, MD regarding "The risk of developing coronary artery disease or congestive heart failure, and overall mortality, in type 2 diabetic patients receiving rosiglitazone, pioglitazone, metformin, or sulfonylureas: a retrospective analysis"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19306084 [PubMed - as supplied by publisher]
Source: Acta Diabetol AND (h... - March 22, 2009 Category: Endocrinology Authors: Zimmerman RS, Pantalone KM Tags: Acta Diabetol Source Type: journals

Pantalone et al.: The risk of developing coronary artery disease or congestive heart failure, and overall mortality, in type 2 diabetic patients receiving rosiglitazone, pioglitazone, metformin, or sulfonylureas: a retrospective analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19300899 [PubMed - as supplied by publisher]
Source: Acta Diabetol AND (h... - March 20, 2009 Category: Endocrinology Authors: Bell DS Tags: Acta Diabetol Source Type: journals

Universal versus selective screening for the detection, control and prognosis of gestational diabetes mellitus in Argentina.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, all non-hyperglycaemic 24-28-week pregnant women should be tested for GDM, although particular attention must be paid to MG women with risk factors. PMID: 19300898 [PubMed - as supplied by publisher]
Source: Acta Diabetol AND (h... - March 20, 2009 Category: Endocrinology Authors: McCarth...D, Curciarello R, Castiglione N, Tayeldín MF, Costa D, Arnol V, Prospitti A, Aliano A, Arch... D, Graieb A, Torres MJ, Etch...rry SB, Apezteguía MC Tags: Acta Diabetol Source Type: journals

Failure to metformin and insulin secretagogue monotherapy: an observational cohort study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, insulin secretagogues are associated with increased failure rate in comparison with metformin. This difference could be due to detrimental effect of secretagogues, rather than to a beneficial action of metformin. PMID: 19290462 [PubMed - as supplied by publisher]
Source: Acta Diabetol AND (h... - March 17, 2009 Category: Endocrinology Authors: Pala L, Monami M, Lamanna C, Cresci B, Colombi C, Bardini G, Sposato J, March...ni N, Rotella CM, Mannucci E Tags: Acta Diabetol Source Type: journals

Newly detected glucose disturbance is associated with a high prevalence of diastolic dysfunction: double risk for the development of heart failure?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diastolic dysfunction is associated with a high rate of morbidity and mortality and has a high prevalence in patients with diabetes. Aim of the study was to investigate the prevalence of diastolic dysfunction in patients with newly detected glucose metabolism disorder (GMD) submitted for coronary angiography. Oral glucose tolerance test, echocardiography, and tissue Doppler imaging were performed in patients referred to coronary angiography. Prevalence of diastolic dysfunction was 97, 88, and 74% in the known diabetes, newly detected diabetes, and new diagnosed impaired glucose toleranc group, respectively. This is hig...
Source: Acta Diabetol AND (h... - March 11, 2009 Category: Endocrinology Authors: Füth... Dinh... Bansemir L, Ziegler G, Bufe A, Wolfertz J, Sch...old T, Lankisch M Tags: Acta Diabetol Source Type: journals

Intellectual ability in early adulthood and type 2 diabetes in later life.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study is to assess whether intellectual ability in young adult men predicts the development of type 2 diabetes in later life. 641 men participating in the Helsinki Birth Cohort Study were administered a 2-h (75 g) oral glucose tolerance test at a mean age of 61 years. Intellectual ability was assessed during compulsory military service at a mean age of 20 years. Associations were explored using linear and logistic regression models. Intellectual ability in young adulthood did not predict glucose tolerance at age 61 years. However, educational attainment was associated with the prevalence of type 2 diabe...
Source: Acta Diabetol AND (h... - March 7, 2009 Category: Endocrinology Authors: Paile-h...#xE4;rinen M, Kajantie E, Räikkönen K, h...iksson M, Leskinen JT, Laaksonen I, Forsén T, Eriksson JG Tags: Acta Diabetol Source Type: journals

The geospatial relation between UV solar radiation and type 1 diabetes in Newfoundland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigates the geospatial association between average daily ultraviolet B (UVB) irradiance and T1DM across the province of Newfoundland (NL), Canada. NL has one of the highest documented incidences of T1DM worldwide. A complete list of patients diagnosed (1987-2005) with T1DM in the province of Newfoundland and Labrador (NL) was constructed using multiple sources. All places of habitation at diagnosis were ascertained. Ecological analysis using Bayesian estimation was performed employing both NASA UVB data and latitude. Correlation of T1DM to both UVB irradiation and latitude was measured. A statistically sign...
Source: Acta Diabetol AND (h... - February 24, 2009 Category: Endocrinology Authors: Sloka S, Grant M, Newh... LA Tags: Acta Diabetol Source Type: journals

Relationship between white blood cell count and components of metabolic syndrome among young adolescents.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion BMI was positively correlated with WBCC in young adolescent females and males. Thus, BMI is the most important component of MetS in this age group. In addition, TG levels in males and FPG in females were significantly related to WBCC. These findings could be regarded an early indication for the future development of full-blown MetS or cardiovascular diseases. PMID: 19238313 [PubMed - as supplied by publisher]
Source: Acta Diabetol AND (h... - February 24, 2009 Category: Endocrinology Authors: Wu CZ, h...o FC, Lin JD, Su CC, Wang KS, Ch...M, Lee Lh...ang K, h... TL, Pei D Tags: Acta Diabetol Source Type: journals

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