Acta DiabetologicaThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2 3 4 5 6 7 8

365 records returned

G.B. Morgagni Prizes 2010Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory AnnouncementDOI 10.1007/s00592-009-0155-yAuthors Gaetano Crepaldi, The G.B. Morgagni Prizes, C.N.R. Istituto di Neuroscienze Padova, Sezione Invecchiamento, Via Giustiniani 2 35128 Padua Italy Journal Acta DiabetologicaOnline ISSN 1432-5233Print ISSN 0940-5429 Journal Volume Volume 46 Journal Issue Volume 46, Number 4 / December, 2009 (Source: Acta Diabetologica)
Source: Acta Diabetologica - November 4, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in the Palestinian populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the association of rs7903146 variant in the transcription factor 7 like 2 gene (TCF7L2) with T2DM in 333 Palestinian subjects (219 were type 2 diabetic patients and 114 normoglycemic subjects). The rs7903146 variant of TCF7L2 significantly increased T2DM risk with an allelic odds ratio of 3.34 (95% CI [1.99–5.60], P < 0.0001). No significant association was observed between TCF7L2 genotypes and covariates of age, gender and BMI or any tested metabolic trait (total cholesterol and fasting plasma glucose) in both diabetic and nondiabetic individuals (P > 0.05). Among the diabetic gr...
Source: Acta Diabetologica - November 3, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Breviscapine ameliorates cardiac dysfunction and regulates the myocardial Ca2+-cycling proteins in streptozotocin-induced diabetic ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To investigate the influence of breviscapine on the cardiac structure and function in diabetic cardiomyopathy rats as well as the expression of protein kinase C (PKC) and Ca2+-cycling proteins expression. Diabetes was induced in male Sprague–Dawley rats by a single intraperitoneal injection of streptozotocin and the control rats were injected with saline. After the induction of diabetes for 4 weeks, the animals were divided into different groups: (1) normal rats as control; (2) diabetic rats; (3) diabetic rats with administration of breviscapine (10 or 25 mg kg−1 day−2). Af...
Source: Acta Diabetologica - October 30, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Increasing evidence suggests that a restricted caloric intake extends the life span of mammals, and SIRT1 may play a key role in this process. To study the effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats, we first induced a model of type 2 diabetes in rats with a low-dose of streptozotocin. Then, the rats were fed with a normal diet, high-fat diet or 60% caloric restriction, respectively. As a result, the apoptosis ratio of islet beta cells in diabetic rats was dramatically increased compared to the control group, and mRNA and protein expr...
Source: Acta Diabetologica - October 29, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Erratum to: Variants of the adiponectin gene and type 2 diabetes in a Polish populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00592-009-0163-yAuthors Magdalena Szopa, Jagiellonian University Department of Metabolic Diseases, Medical College 15 Kopernika Street 31-501 Kraków PolandMalgorzata Malczewska-Malec, Jagiellonian University Department of Clinical Biochemistry, Medical College Kraków PolandBeata Kiec-Wilk, Jagiellonian University Department of Clinical Biochemistry, Medical College Kraków PolandJan Skupien, Jagiellonian University Department of Metabolic Diseases, Medical College 15 Kopernika Street 31-501 Kraków PolandPawel Wolkow, Jagiellonian University Department of Pharm...
Source: Acta Diabetologica - October 28, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Angiotensin-converting enzyme gene polymorphism is associated with proliferative diabetic retinopathy: a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The association of angiotensin-converting enzyme (ACE) gene polymorphism with diabetic retinopathy (DR) was investigated in many studies with conflicting results. To shed light on these inconclusive findings, a meta-analysis of all available studies relating I (insert)/D (delete) polymorphism to the risk of developing DR was conducted. This meta-analysis included genotype data on 2,342 cases with DR and 2,048 controls free of DR. Summary odds ratios were estimated. Potential sources of heterogeneity and bias were explored. Overall, in allelic genetic model, heterogeneity between studies was nonsigni...
Source: Acta Diabetologica - October 28, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

The effects of telmisartan on mechanical responses of left ventricular papillary muscle in rats with streptozotocin-induced diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our data suggest that telmisartan attenuates diabetes-induced impairment of diabetic rat papillary muscles, and may thus be able to reduce cardiac complications in diabetes. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0156-xAuthors Mustafa Emre, Cukurova University Department of Biophysics, School of Medicine 01330 Adana TurkeyServet Kavak, Cukurova University Department of Biophysics, School of Medicine 01330 Adana TurkeyHakki Unlugenc, Cukurova University Department of Anesthesiology, School of Medicine Adana Turkey Journal Acta DiabetologicaOnline ISSN 1432-523...
Source: Acta Diabetologica - October 24, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Insulin resistance and impaired glucose tolerance precede the development of type 2 diabetes. In 2006, the BASF Occupational Medicine and Health Protection Department offered a diabetes screening program for 33,000 employees. 1,594 employees had their diabetes risk tested: 285 employees were at medium to high risk for diabetes type 2, according to the Finrisk score. Hundred and fifty-seven of these individuals underwent oral glucose tolerance testing: 22 were shown to have impaired glucose tolerance (IGT), and 5 had manifest diabetes. Thus, 18% of this worksite sample population were affected by IGT...
Source: Acta Diabetologica - October 24, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Diabetes and the risk of sudden cardiac death, the Atherosclerosis Risk in Communities studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined the association of type 2 diabetes with the incidence of sudden cardiac death when compared to the incidence of non-sudden cardiac death and non-fatal myocardial infarction (MI). We used data from the Atherosclerosis Risk in Communities (ARIC) study to examine the incidence of sudden and non-sudden cardiac death and non-fatal MI among persons with and without diabetes in follow-up from the baseline data collection (1987–1989) through December 31, 2001. There were 209 cases of sudden cardiac death, 119 of non-sudden cardiac death, and 739 of non-fatal MI identified in this cohort over an av...
Source: Acta Diabetologica - October 24, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Body mass index and acid phosphatase locus 1 in diabetic disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The polymorphic enzyme acid phosphatase locus 1 (ACP1) is a candidate gene for obesity disorders. The enzyme is able to dephosphorylate the insulin receptor. Our group has observed a lower plasma glucose level in diabetic subjects carrying the low activity ACP1 phenotypes A and BA, and a positive association between these genotypes and body mass index (BMI). We have now analysed the relationship between BMI and ACP1 in gestational diabetes and in women with type 1 diabetes. We have studied 106 Caucasian women with type 1 diabetes who had previously delivered a liveborn infant, 99 Caucasian women who...
Source: Acta Diabetologica - October 24, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we tested the hypothesis that the CHEK2 gene contains one or more polymorphic variants that are associated with type 2 diabetes in HyperGEN individuals. In addition, we replicated our findings in two other Family Blood Pressure Program (FBPP) populations and in the population-based Atherosclerosis Risk in Communities (ARIC) study. We genotyped 1,584 African-American and 1,531 white HyperGEN participants, 1,843 African-American and 1,569 white GENOA participants, 871 African-American and 1,009 white GenNet participants, and 4,266 African-American and 11,478 white ARIC participants for four single nucleot...
Source: Acta Diabetologica - October 24, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Clinical characteristics of patients with type 2 diabetes mellitus at the time of insulin initiation: INSTIGATE observational study in SpainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Little information is available on the management of patients with type 2 diabetes mellitus (DM2) in regular clinical practice, prior to and at the point of initiating treatment with insulin. The INSTIGATE study provides a description of the clinical profile of the patient with DM2 who begins treatment with insulin in both primary and secondary care. A total of 224 patients who had been diagnosed with DM2, were not responding to oral treatment, and began receiving insulin were included in the INSTIGATE study in Spain. Demographic data were collected, as well as data on macro- and microvascular compl...
Source: Acta Diabetologica - October 24, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Excessive maternal transmission of diabetes in Japanese families with young-onset type 2 diabetes and insulin secretion defect according to clinical featuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of the study is to identify the clinical characteristics of Japanese patients with young-onset type 2 diabetes (YT2D). Family history of diabetes and clinical data were collected for 30 unrelated males (from 11 to 20 years old at age of onset) and 20 females (from 10 to 20 years old at age of onset) with YT2D diagnosed at ≤20 years of age. Fasting C-peptide levels were measured in all, and glucagon stimulation tests were performed twice in six of them over several years. Moreover, 858 people with type 2 diabetes (T2D) diagnosed at >20 years of age were randomly recru...
Source: Acta Diabetologica - September 29, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

The relationship between coronary artery calcification score, plasma osteoprotegerin level and arterial stiffness in asymptomatic type 2 DMEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Because T2DM increases the risk of coronary atherosclerosis and CAD and new noninvasive techniques to assess CVD risk have gained considerable popularity, it is important to know how these tools relate to each other. The aim of this study was to evaluate the relationship between the extent of coronary artery calcification measured by MDCT, plasma OPG levels, baPWV and the established cardiovascular risk factors in Korean patients with T2DM. From November 2006 to December 2007, 110 asymptomatic Korean patients with T2DM without prior evidence of CAD were assessed (mean age 57.2 years). CAC imagi...
Source: Acta Diabetologica - September 29, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

DNA damage evaluated by comet assay in Mexican patients with type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, given that general DNA damage was similar in the three groups of patients with DM2 and the control group, it is possible that these cells showed similar oxidative damage, as has been proposed previously. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0149-9Authors Emma Ibarra-Costilla, Instituto Mexicano del Seguro Social (IMSS) Unidad de Medicina Familiar No. 46 Monterrey MexicoRicardo M. Cerda-Flores, Centro de Investigación Biomédica del Noreste, IMSS División de Genética Administración de Correos No 4. Apartado postal 20 C. P. 64720 Monterrey NL MexicoMartha I. Dá...
Source: Acta Diabetologica - September 29, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Effect of pioglitazone on systemic inflammation is independent of metabolic control and cardiac autonomic function in patients with type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this article is to investigate the relation of the anti-inflammatory effect of pioglitazone with cardiac autonomic function and metabolic control in diabetic patients. In this prospective open label trial, 36 type 2 diabetic patients (age 60 ± 10, 20 M) without overt cardiovascular disease were randomized to add pioglitazone (30 mg) to their therapy or to continue standard therapy. C-reactive protein (CRP) serum levels, metabolic parameters and cardiac autonomic function (assessed by heart rate variability [HRV] on 24-h ECG Holter monitoring) were measured at baseline...
Source: Acta Diabetologica - September 29, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Erratum to: Prevalence and correlates of inadequate glycaemic control: results from a nationwide survey in 6,671 adults with diabetes in BrazilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00592-009-0147-yAuthors Ana Beatriz Valverde Mendes, São Paulo Federal University Rua Botucatu, 740 São Paulo 04023-900 BrazilJoão Antônio Saraiva Fittipaldi, Pfizer Inc. Rua Alexandre Dumas 1860, Chácara Santo Antonio São Paulo 04717-904 BrazilRaimundo Celestino Silva Neves, Oswaldo Cruz Foundation, Brazilian Ministry of Health Gonçalo Moniz Research Center Rua Waldemar Falcão 121, Salvador Bahia 40296-710 BrazilAntônio Roberto Chacra, São Paulo Federal University Rua Botucatu, 740 São Paulo 04023-900 BrazilEdson Duarte Moreira, Oswaldo Cruz Foundatio...
Source: Acta Diabetologica - September 29, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Low serum osteoprotegerin levels in normoalbuminuric type 1 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this study is to establish whether abnormal mineral metabolism is present in patients with type 1 DM with normal renal function and in the absence of microalbuminuria. Serum levels of 1,25-dihydroxyvitamin D, osteoprotegerin (OPG) and receptor activator for nuclear factor kappa β ligand (RANKL) and other determinants of bone metabolism were measured in 35 patients with type 1 DM and in 25 age-, sex- and ethnicity-matched healthy controls. Serum OPG (1.98 vs. 2.98 pmol/l: P = 0.001), 1,25-dihydroxyvitamin D (41.1 vs. 48.2 pmol/l: P = 0.035) and magnesium (0.84...
Source: Acta Diabetologica - September 29, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Middle age is not associated with altered fibrinogen concentration and production in malesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Whether ageing is associated with increased fibrinogen concentration and production remains unclear. We measured fibrinogen fractional (FSR) and absolute synthesis (ASR) rates in male volunteers, of either young (mean age: 28 years, range: 22–34) or middle age (mean age: 57 years, range: 38–72), using a leucine-tracer isotope dilution technique. In the middle-age group, neither fibrinogen FSR (20.8 ± 1.6%/day) nor ASR (1.8 ± 0.1 g/day), or concentration (274 ± 15 mg/dl), were different from those of the younger group (FSR: 20.2 ± 1.4; ASR: 1....
Source: Acta Diabetologica - September 24, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Are measures of height and leg length related to incident diabetes mellitus? The ARIC (Atherosclerosis Risk in Communities) studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to estimate the risk of developing diabetes in relation to adult height components, namely leg length and leg length/height ratio. Data on 12,800 individuals without diabetes were obtained at the baseline examination from the ARIC cohort. Cox proportional hazard models were used to estimate hazard rate ratios of diabetes for each 5-cm difference in leg length and 1 SD difference in the leg length/height ratio. During a mean follow-up period of 7.6 years, the age-adjusted incidence per 1,000 person years of follow-up was 25.8, 24.2, 10.4, and 16.2 in African American (AA) women, AA men, whit...
Source: Acta Diabetologica - September 24, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Insulin-like growth factor binding protein: a possible marker for the metabolic syndrome?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Insulin-like growth factor (IGF) binding proteins (IGFBPs) moved on to contain both IGF high- and low-affinity binders, exerting mitogenic and metabolic actions through its complex interplay between IGF/insulin and its IGF/insulin-independent manner. Progress on the metabolic-related function of IGFBPs has been rapid in recent years. A wealth of studies in 3T3-L1 adipocytes and the transgenic mice models demonstrated that IGFBPs played important roles in the pathogenesis of obesity and insulin resistance. Studies conducted in humans demonstrated the close relation between IGFBPs and the components o...
Source: Acta Diabetologica - September 22, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Effects of intermittent high glucose on oxidative stress in endothelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, intermittent high glucose induced more ROS in PIECs than constant high glucose, this effect seemed to be, at least in part related to the enhanced activation of NADPH oxidase. Glucose fluctuation may be involved in the development of vascular complications. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0140-5Authors Qin-Min Ge, Shanghai Jiaotong University School of Medicine Department of Endocrinology, Xinhua Hospital Shanghai 200092 ChinaYan Dong, Shanghai Jiaotong University School of Medicine Department of Endocrinology, Xinhua Hospital Shanghai 200092 ChinaHong-Mei Z...
Source: Acta Diabetologica - September 18, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Combined use of fasting plasma glucose and glycated hemoglobin A1c in the screening of diabetes and impaired glucose toleranceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this study is to assess the validity of combined use of fasting plasma glucose (FPG) and glycated hemoglobin A1c (HbA1c) as screening tests for diabetes and impaired glucose tolerance (IGT) in high-risk subjects. A total of 2,298 subjects were included. All subjects underwent a 75-g oral glucose tolerance test (OGTT) and HbA1c measurement. Receiver operating characteristic curve (ROC curve) analysis was used to examine the sensitivity and specificity of FPG and HbA1c for detecting diabetes and IGT, which was defined according to the 1999 World Health Organization (WHO) criteria. (1) Based...
Source: Acta Diabetologica - September 17, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Metabolic syndrome is independently associated with microalbuminuria in type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00592-009-0141-4Authors Alireza Esteghamati, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O. Box 13145-784 Tehran IranArmin Rashidi, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O. Box 13145-784 Tehran IranOmid Khalilzadeh, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O. Box 13145-784 Tehran IranHaleh Ashraf, Tehran University of Medical Sciences Endocrinology and Meta...
Source: Acta Diabetologica - August 25, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Computation of the excess glucose and Na deficit of hypo-osmolar hyponatremic hyperglycaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Exact computations of glucose accumulation (GA, mM) and Na anions deficit (ΔNa, mEq) can be obtained in hypo-osmolar hyponatremic hyperglycaemia (HHH), where plasma osmolality (POsm) is lower than normal. In this condition, GA − ΔNa = ∆POsm × TBW (total body water). GA is given by plasma glucose concentration (PG1) times extra-cellular volume (ECV), calculated as TBW − ICV (the known intra-cellular volume). The changes in solute content can then be computed from their concentrations. This model was verified on computer-simulated patients to whom GA...
Source: Acta Diabetologica - August 12, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Prevalence and correlates of inadequate glycaemic control: results from a nationwide survey in 6,671 adults with diabetes in BrazilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to estimate the prevalence of inadequate glycaemic control and its correlates in a large multicentre survey of Brazilian patients with diabetes. A cross-sectional study was conducted in a consecutive sample of patients aged 18 years or older with either type 1 or type 2 diabetes, attending health centres located in ten large cities in Brazil (response rate = 84%). Information about diabetes, current medications, complications, diet, and satisfaction with treatment were obtained by trained interviewers, using a standardized questionnaire. Glycated haemoglobin (HbA1c) was measured by high...
Source: Acta Diabetologica - August 5, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Lower BMI cutoff for assessing the prevalence of metabolic syndrome in Thai populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article investigates the prevalence of metabolic syndrome (MS) and the benefits of lowered body mass index (BMI) cutoff point for assessing MS prevalence in a large, nationally representative population sample comprising of 15,365 Thai adults from metropolitan Bangkok who received annual checkup. Prevalence of MS was characterized using the International Diabetes Federation criteria and BMI ≥25 kg/m2 as cutoff revealed that 26.63% of male and 14.90% of female subjects had MS and the prevalence was age dependent. Traditional BMI cutoff of ≥30 kg/m2 underestimated MS prevalence in Thai population while...
Source: Acta Diabetologica - July 31, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Maternal physical activity before and during early pregnancy as a risk factor for gestational diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this study was to assess whether the levels of physical activity before and during early pregnancy are associated with the prevalence of gestational diabetes mellitus (GDM). The study group included 160 puerperas. Among them, 40 (25%) diagnosed as having GDM during their recent pregnancy, whereas the remaining 120 (75%) served as controls. The international physical activity questionnaire (IPAQ-Greek version) was applied twice, in an attempt to estimate the level of physical activity before and during early pregnancy. Women who were “inactive” before or during early pregnancy had odds...
Source: Acta Diabetologica - July 18, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Insulin analogs and pregnancy: an updateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract It is well known that good metabolic control maintained throughout pregnancy reduces maternal and fetal complications in diabetes. Before conception and throughout pregnancy, insulin therapy needs to be optimized and, in this context, the insulin analogs currently available in the market may help to achieve good metabolic control. We therefore review here what is known about the potential benefits and risks related to the use of these new insulins in pregnancy. Clinical and experimental data on insulin aspart and lispro strongly suggest that they have no adverse maternal or fetal effects during preg...
Source: Acta Diabetologica - July 6, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Animal insulin therapy induces a biased insulin antibody response that persists for years after introduction of human insulinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigates the parameters affecting IA frequency and binding levels in a cohort of type 1 diabetes (T1D) patients. All patients were treated with human recombinant insulin. About half of the patients had received animal insulin prior to the introduction of human recombinant insulin. We tested the IA frequency and binding level for all serum samples. IA were further analyzed for their epitope specificity comparing human and porcine insulin binding. We found that T1D patients who received animal insulin in the past show significantly higher IA binding levels as compared to patients treated exclusively with ...
Source: Acta Diabetologica - June 23, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Is the current therapeutic armamentarium in diabetes enough to control the epidemic and its consequences? What are the current shortcomings?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The prevalence of diabetes is expected to rise together with an increase in morbidity and a reduction in life expectancy. A leading cause of death is cardiovascular disease, and hypertension and diabetes are additive risk factors for this complication. Selected treatment options should neither increase cardiovascular risk in patients with diabetes, nor increase risk of hyperglycaemia in patients with hypertension. The efficacy of present antihyperglycaemic agents is limited and new therapies, such as incretin-targeted agents, are under development. Even though most patients do not achieve glycated h...
Source: Acta Diabetologica - June 20, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Transcription factor 7-like 2-gene polymorphism is related to fasting C peptide in latent autoimmune diabetes in adults (LADA)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the data from this study confirmed previous results showing genetic similarities between patients with LADA and type 2 diabetes. Non-autoimmune mechanism may be related to beta cell dysfunction in patients with LADA. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00592-009-0133-4Authors Barbara Szepietowska, Yale University School of Medicine Section of Endocrinology, Department of Internal Medicine New Haven CT USADariusz Moczulski, Medical University of Lodz Department of Internal Medicine and Nephrodiabetology Lodz PolandNatalia Wawrusiewicz-Kurylonek, Medical University of Bia...
Source: Acta Diabetologica - June 17, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Continuous subcutaneous insulin infusion versus multiple daily insulin injections in type 1 diabetes: a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Continuous subcutaneous insulin infusion (CSII) is considered an option for type 1 diabetic patients unsatisfactorily controlled with multiple daily injections (MDI). Short-acting analogs are superior to regular human insulin in CSII. This meta-analysis is aimed at assessing the advantages of short-acting analog-based CSII over MDI in type 1 diabetes. Randomized clinical trials (RCTs) comparing CSII (with analogs) and MDI for at least 12 weeks in type 1 diabetic patients were retrieved, assessing between-group differences in HbA1c and incidence of hypoglycemia. A total of 11 RCTs was included i...
Source: Acta Diabetologica - June 6, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Exercise for the management of type 2 diabetes: a review of the evidenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim is to critically review the more relevant evidence on the interrelationships between exercise and metabolic outcomes. The research questions addressed in the recent specific literature with the most relevant randomized controlled trials, meta-analysis and cohort studies are presented in three domains: aerobic exercise, resistance exercise, combined aerobic and resistance exercise. From this review appear that the effects of aerobic exercise are well established, and interventions with more vigorous aerobic exercise programs resulted in greater reductions in HbA1c, greater increase in VO2max ...
Source: Acta Diabetologica - June 4, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Metabolic syndrome is independently associated with microalbuminuria in type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, MetS is independently associated with microalbuminuria in type 2 diabetes. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0131-6Authors Alireza Esteghamati, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O. Box 13145-784 Tehran IranArmin Rashidi, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O. Box 13145-784 Tehran IranOmid Khalilzedeh, Tehran University of Medical Sciences Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital P.O....
Source: Acta Diabetologica - May 29, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Exercise therapy in Type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Structured exercise is considered an important cornerstone to achieve good glycemic control and improve cardiovascular risk profile in Type 2 diabetes. Current clinical guidelines acknowledge the therapeutic strength of exercise intervention. This paper reviews the wide pathophysiological problems associated with Type 2 diabetes and discusses the benefits of exercise therapy on phenotype characteristics, glycemic control and cardiovascular risk profile in Type 2 diabetes patients. Based on the currently available literature, it is concluded that Type 2 diabetes patients should be stimulated to parti...
Source: Acta Diabetologica - May 29, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

The oxidative stress status in diabetes mellitus and diabetic nephropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this study is to assess the oxidative stress status in diabetes mellitus (DM) and diabetic nephropathy. The study group comprised 40 control subjects, 40 type 2 DM patients without complications and 37 diabetic nephropathies. Compared with control subjects, superoxide dismutase, glutathione peroxidase, catalase, vitamin C were decreased (P < 0.01). There was a significant increase in serum malondialdehyde (MDA), conjugated diene (CD), advanced oxidation protein products (AOPP), protein carbonyl (PC) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in diabetes patients when compared ...
Source: Acta Diabetologica - May 28, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Circulating vascular endothelial growth factor in the normo- and/or microalbuminuric patients with type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Relationship between serum vascular endothelial growth factor (VEGF) level and parameters of endothelial injury and/or dysfunction in patients with diabetes mellitus type 2 with or without microalbuminuria was investigated. Eighty-four diabetic patients were divided in two subgroups (42 each): normoalbuminuric (NAU) and microalbuminuric (MAU). Forty-two blood donors were in control group. Serum VEGF and plasma von Willebrand factor, soluble thrombomodulin, plasminogen activator inhibitor 1, thrombin-activatable fibrinolysis inhibitor (TAFI) and tissue plasminogen activator (t-PA) were measured using...
Source: Acta Diabetologica - May 13, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, serum CRP level is significantly associated with obesity, especially the visceral adipose tissue, and serum leptin is another important independent factor associated with CRP in Korean type 2 diabetic patients. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0125-4Authors Jong Suk Park, Yonsei University College of Medicine Department of Internal Medicine Seoul KoreaMin Ho Cho, Yonsei University College of Medicine Department of Internal Medicine Seoul KoreaJi Sun Nam, Yonsei University College of Medicine Department of Internal Medicine Seoul KoreaChul Woo Ahn, Yonsei Unive...
Source: Acta Diabetologica - May 5, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Influence of iron metabolism indices on glycated haemoglobin but not glycated albumin levels in premenopausal womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusions, iron metabolism indices influence HbA1C levels, but not serum GA levels, in premenopausal women. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0123-6Authors Masafumi Koga, Kinki Central Hospital Department of Internal Medicine Kuruma-zuka 3-1 Itami Hyogo 664-8533 JapanHiroshi Saito, Kinki Central Hospital Department of Internal Medicine Kuruma-zuka 3-1 Itami Hyogo 664-8533 JapanMikio Mukai, Kinki Central Hospital Department of Internal Medicine Kuruma-zuka 3-1 Itami Hyogo 664-8533 JapanSoeko Matsumoto, Kinki Central Hospital Department of Clinical Laboratory Itami JapanSoj...
Source: Acta Diabetologica - April 30, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

How increased VEGF induces glomerular hyperpermeability: a potential signaling pathway of Rac1 activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Despite growing evidence for a pathogenic role of vascular endothelial growth factor (VEGF) in microvascular complications of diabetes, the underlying mechanism responsible for its detrimental effect remains unknown. In the current study, we hypothesized that some of the detrimental effects of VEGF on microvascular endothelial cells in the diabetic milieu stem from its aberrant signaling, which leads to perturbed tight junction assembly and increased endothelial permeability. Using an integrated in vitro approach, we investigated whether the effect of VEGF on endothelial cell permeability involves R...
Source: Acta Diabetologica - April 30, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Effects of high glucose and thiamine on the balance between matrix metalloproteinases and their tissue inhibitors in vascular cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We reported on reduced pericyte adhesion to high glucose-conditioned ECM and correction by thiamine. We aimed at verifying the effects of thiamine and benfotiamine on MMP-2, MMP-9 and TIMP expression and activity in human vascular cells with high glucose. In HRP, MMP-2 activity, though not expression, increased with high glucose and decreased with thiamine and benfotiamine; TIMP-1 expression increased with high glucose plus thiamine and benfotiamine; MMP-9 was not expressed. In EC, MMP-9 and MMP-2 expression and activity increased with high glucose, but thiamine and benfotiamine had no effects; TIMP-1 expression was u...
Source: Acta Diabetologica - April 30, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Analysis of the membrane fluidity of erythrocyte ghosts in diabetic, spontaneously hypertensive ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Diabetes and hypertension are closely related diseases associated with changes in membrane fluidity. Here, we measured the membrane fluidity of erythrocyte ghosts from spontaneously hypertensive rats (SHR), with or without streptozotocin (STZ)-induced diabetes, at the ages of 1, 3 and 6 months, by introducing the use of the intramolecular excimer forming dipyrenylpropane (DPyP) in this model. Type 2 diabetes mellitus (T2DM) was induced in 48-h-old, newborn male SHR by intraperitoneal injection of STZ. We found lower excimer to monomer (I e/I m) DPyP ratios in diabetic SHR than in control SHR ...
Source: Acta Diabetologica - April 30, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Glucose levels during oral glucose tolerance tests and gamma-glutamyl transpeptidase are predictors of change from normal to impaired glucose tolerance in healthy middle-aged Japanese menEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We evaluated the predictors of the development from normal to impaired glucose tolerance (IGT) in healthy middle-aged Japanese men. Forty male subjects who showed normal glucose tolerance (NGT) levels based on WHO criteria and who had undergone 75-g OGTT annually for 10 years were selected in the database of medical checkups retrospectively, and divided into two groups: those retaining NGT and those that developed IGT. Gamma-glutamyl transpeptidase (GGT) and the glucose levels at 30 and 60 min were significantly associated with the development of IGT in the Cox proportional hazard model. H...
Source: Acta Diabetologica - April 24, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Association of homozygous SDF-1 3′A genotype with proliferative diabetic retinopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Stromal cell-derived factor 1 (SDF-1) is involved in the development of experimental proliferative retinopathy. Since little data are available on the genetic predisposition or on biomarkers predicting the development of proliferative retinopathy, we assessed the distribution of the SDF-1 3′A genotype in 130 diabetic patients with retinopathy. In patients with proliferative retinopathy, the frequency of the homozygous SDF-1 3′A genotype was significantly higher than in patients with non-proliferative retinopathy (10.9% of PDR vs. 0 of NPDR, P = 0.01). This association was confirmed whe...
Source: Acta Diabetologica - April 21, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Lack of association between TNF 238 G/A polymorphism and type 2 diabetes: a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this meta-analysis was to determine the nature of the association between TNF 238 G/A polymorphism and the risk for T2D. We searched databases updated on January 2009 for all publications on the association between this variation and T2D. Data on genotypes and the numbers of cases and controls were assessed using Review Manager 4.2. Meta-analysis of the overall and specific populations was conducted, and odds ratios (OR) and 95% confidence intervals (95% CI) were calculated in the fixed-effect model. I 2 statistic was calculated to examine heterogeneity, and publication bias was evaluated...
Source: Acta Diabetologica - April 15, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Early microvascular complications of prediabetes in mice with impaired glucose tolerance and dyslipidemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Microvascular complications are an important cause of morbidity in diabetic patients and can be detected in a significant number of patients at the time of diabetes diagnosis. However, little is known about the alterations in the microvasculature previous to the clinical manifestation of diabetes mellitus type 2. To obtain more insights into the early microvascular deterioration resulting from prediabetes, morphological and functional microvascular parameters were monitored using intravital fluorescence microscopy through a dorsal skin-fold chamber preparation in the uncoupling promotor-driven dipht...
Source: Acta Diabetologica - April 15, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

TAQIB and I405V polymorphisms of CETP are moderately associated with obesity risk in the Chinese adult populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, less common alleles of TAQIB and I405V appear to be modestly associated with obesity risk in an adult Chinese population. Adjustments for HDL levels completely (TAQIB) or partially (I405V) abolished the observed association. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00592-009-0117-4Authors Xiaoyang Ruan, Beijing Hypertension League Institute Laboratory of Human Genetics Beijing ChinaLina Ma, Beijing Hypertension League Institute Laboratory of Human Genetics Beijing ChinaShuyu Wang, Beijing Hypertension League Institute Laboratory of Human Genetics Beijing ChinaKlaus Lindpaintne...
Source: Acta Diabetologica - April 10, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Beneficial effects of astragalus polysaccharides treatment on cardiac chymase activities and cardiomyopathy in diabetic hamstersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the effects of APS treatment on cardiac function, myocardial collagen expression, cardiac ultrastructure, cardiac matrix metalloproteinase (MMP) activity, levels of plasma glycosylated serum protein (GSP), and myocardial enzymes, and the expression of Ang II, chymase, and angiotensin-converting enzyme (ACE) in the diabetic hamster myocardium. Diabetes was induced by a single injection of streptozotocin (60 mg/kg ip). The experimental groups consisted of normal control (n = 15), diabetic (n = 15), insulin-treated diabetic (n = 15, NPH 1–2 U/day ip)...
Source: Acta Diabetologica - April 7, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals

Hyperglycaemia in critical illness is a risk factor for later development of type II diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Hyperglycaemia caused by stress and inflammation is common during critical illness. We hypothesised that a latent glucose metabolism disturbance contributes to development of hyperglycaemia and that those patients have increased risk for diabetes. We included patients with sepsis, acute coronary syndrome and acute heart failure with no history of impaired glucose metabolism and divided them in the hyperglycaemia group (glucose ≥ 7.8 mmol/l) and normoglycaemia group. Patients were followed for 5 years. Follow-up was completed for 115 patients in the normoglycaemia group, of whic...
Source: Acta Diabetologica - April 2, 2009 Category: Endocrinology Tags: Acta Diabetologica Source Type: journals