The association of islet autoantibodies with the neural retinal thickness and microcirculation in type 1 diabetes mellitus with no clinical evidence of diabetic retinopathy
ConclusionsIAbs are associated with neural retinal thinning and microcirculation reduction in T1DM patients before the clinical onset of diabetic retinopathy. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 26, 2024 Category: Endocrinology Source Type: research

Self-supervised category selective attention classifier network for diabetic macular edema classification
ConclusionsThe proposed SSCSAC-Net represents a significant advancement in automated DME classification. By effectively using self-supervised learning and attention mechanisms, the model offers improved accuracy in identifying DME-related features within retinal images. Its robustness and generalizability across different datasets highlight its potential for clinical applications, providing a valuable tool for clinicians in diagnosing DME effectively. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 23, 2024 Category: Endocrinology Source Type: research

Associations of muscle mass and strength with new-onset diabetes among middle-aged and older adults: evidence from the China health and retirement longitudinal study (CHARLS)
ConclusionsLower muscle strength is associated with  an increased risk of diabetes, especially in obese populations. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 20, 2024 Category: Endocrinology Source Type: research

Prevalence of new-onset diabetes mellitus after kidney transplantation: a systematic review and meta-analysis
ConclusionsThe incidence of post-kidney transplantation diabetes is substantial, necessitating early implementation of preventive and control measures to mitigate its occurrence, enhance prognosis, and optimize patients' quality of life.Clinical trial registration: PROSPERO: CRD42023465768. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 20, 2024 Category: Endocrinology Source Type: research

Neutrophil gelatinase-associated lipocalin (NGAL) levels in twin pregnancy and association with gestational diabetes
(Source: Acta Diabetologica)
Source: Acta Diabetologica - March 20, 2024 Category: Endocrinology Source Type: research

Association between stress hyperglycemia ratio with short-term and long-term mortality in critically ill patients with ischemic stroke
ConclusionsOur results suggest that stress hyperglycemia, defined by the glucose/HbA1c ratio, is associated with increased short-term and long-term mortality in patients with ischemic stroke, independent of the patient's diabetes status. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 19, 2024 Category: Endocrinology Source Type: research

Exploring time in tight range targets (TITR) in drug-naive Japanese individuals with type 2 diabetes
(Source: Acta Diabetologica)
Source: Acta Diabetologica - March 19, 2024 Category: Endocrinology Source Type: research

Longitudinal assessment of classic and 11-oxygenated androgen concentrations and their association with type 2 diabetes mellitus development: the Troms ø study
ConclusionOur results demonstrate that testosterone and 11-oxygenated androgens are associated with T2DM in men before diagnosis and may be potential biomarkers in T2DM risk assessment. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 18, 2024 Category: Endocrinology Source Type: research

Associations between continuous glucose monitoring (CGM) metrics and psycholinguistic measures: a correlational study
ConclusionsThe study highlights the relationship between CGM metrics and psychological variables derived from patients' narratives. In particular, it is possible to hypothesize a positive role of %TIR in reducing depressive feelings in individuals with diabetes, as well as a negative role of depressive feelings in achieving desirable CGM outcomes. Additionally, there is a potential role of glycemic variability, particularly hyperglycemia, in the expression of depressive and sad feelings, which has been less studied compared to the effects of hypoglycemia. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 16, 2024 Category: Endocrinology Source Type: research

Offloading systems for the treatment of neuropathic foot ulcers in patients with diabetes mellitus: a meta-analysis of randomized controlled trials for the development of the Italian guidelines for the treatment of diabetic foot syndrome
ConclusionsAny plantar offloading, compared to the absence of plantar offloading device, is associated with a higher ulcer healing rate. Total contact cast or nonremovable knee-high walker, compared to other offloading devices, is preferable. Surgical offloading for active ulcers, in combination with post-surgery offloading devices, achieves a higher ulcer healing rate when compared to other offloading devices alone. Further studies with a larger cohort of patients with diabetic neuropathic foot ulcers and extended follow-up periods are necessary. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 15, 2024 Category: Endocrinology Source Type: research

Shared and distinct genetics of pure type 1 diabetes and type 1 diabetes with celiac disease, homology in their auto-antigens and immune dysregulation states: a study from North India
ConclusionSame HLA genes provide susceptibility for both T1D and CD. Non-HLA genes CTLA4, PTPN22 and INS provide further susceptibility while different polymorphisms in PTPN22 and INS can discriminate between T1D and T1D  + CD. Epitope homology between autoantigens of two diseases further encourages the two diseases to occur together. The T1D + CD being more common in females along with co-existence of thyroid autoimmunity, and have more immune dysregulated state than T1D alone. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 14, 2024 Category: Endocrinology Source Type: research

Sleep quality in relation to perceived psychological stress in patients with type 2 diabetes and in age- and sex-matched control individuals
ConclusionSleep quality (subjective sleep quality, sleep latency) is worse in patients with type 2 diabetes than in age- and sex-matched controls. Patients with high perceived stress level have worse subjective sleep quality, higher use of sleeping medication, daytime dysfunction than patients with low perceived stress level; no significant differences in sleep quality between controls with high and low stress level. Perceived stress level in patients with type 2 diabetes is related to subjective sleep quality, sleep duration, use of sleep medication, daytime dysfunction, in age- and sex-matched controls —to daytime dysf...
Source: Acta Diabetologica - March 13, 2024 Category: Endocrinology Source Type: research

Gestational diabetes perception profiles based on attachment style: a cross-sectional study
ConclusionsThree GDM perception profiles were identified and the role of attachment styles in shaping these perceptions was confirmed. Further studies are needed to investigate whether a tailored treatment approach based on the predominant attachment style could lead to more positive GDM perceptions, improved glycemic control, and better perinatal outcomes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 13, 2024 Category: Endocrinology Source Type: research

Research progress on the association between glycemic variability index derived from CGM and cardiovascular disease complications
AbstractCurrently, glycated hemoglobin A1c (HbA1c) has been widely used to assess the glycemic control of patients with diabetes. However, HbA1c has certain limitations in describing both short-term and long-term glycemic control. To more accurately evaluate the glycemic control of diabetes patients, the continuous glucose monitoring (CGM) technology has emerged. CGM technology can provide robust data on short-term glycemic control and introduce new monitoring parameters such as time in range, time above range, and time below range as indicators of glycemic fluctuation. These indicators are used to describe the changes in ...
Source: Acta Diabetologica - March 12, 2024 Category: Endocrinology Source Type: research

Mortality of type 2 diabetes in Germany: additional insights from Gompertz models
ConclusionsDiabetes mortality for females and males aged 30  years or older in Germany in 2014 followed the Gompertz law of mortality. The survival information of the population with diabetes during a large part of the lifespan can thus be reduced to the two parameters of the Gompertz distribution. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 11, 2024 Category: Endocrinology Source Type: research