Clinical characteristics of BRAT1-related disease: a systematic literature review
ConclusionsThis is the first comprehensive systematic review to present quantitative data about clinical characteristics of BRAT1-related disease, which helps doctors to recognize and diagnose it easier. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 12, 2024 Category: Neurology Source Type: research
Cavitating leukodystrophy in a case of mitochondrial complex III deficiency due to LYRM7 mutation
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 9, 2024 Category: Neurology Source Type: research
Danger in plain sight: determining who is at highest risk for cefepime induced neurotoxicity and its associated morbidity and mortality
AbstractCefepime is a fourth-generation cephalosporin that is widely used to treat sepsis but is associated with a potentially dangerous neurotoxicity syndrome, cefepime-induced neurotoxicity (CIN). As a result, patients treated with cefepime may be at higher risk for morbidity, including seizures, and mortality. Though the recent ACORN trial concluded that cefepime does not increase the risk of mortality, most of these patients were not critically ill or elderly, two of the most at risk populations for CIN. Further, diagnosis may be difficult in the critical care setting as patients may have multiple reasons for encephalo...
Source: Acta Neurologica Belgica - April 8, 2024 Category: Neurology Source Type: research
A case report of cladribine ‐induced IgG4-associated liver injury
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 8, 2024 Category: Neurology Source Type: research
Danger in plain sight: determining who is at highest risk for cefepime induced neurotoxicity and its associated morbidity and mortality
AbstractCefepime is a fourth-generation cephalosporin that is widely used to treat sepsis but is associated with a potentially dangerous neurotoxicity syndrome, cefepime-induced neurotoxicity (CIN). As a result, patients treated with cefepime may be at higher risk for morbidity, including seizures, and mortality. Though the recent ACORN trial concluded that cefepime does not increase the risk of mortality, most of these patients were not critically ill or elderly, two of the most at risk populations for CIN. Further, diagnosis may be difficult in the critical care setting as patients may have multiple reasons for encephalo...
Source: Acta Neurologica Belgica - April 8, 2024 Category: Neurology Source Type: research
A case report of cladribine ‐induced IgG4-associated liver injury
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 8, 2024 Category: Neurology Source Type: research
Investigations into the anatomical location, physiological function, clinical implications, and significance of the nucleus of Perlia
ConclusionsThe study of the NP holds clinical implications for understanding the neural mechanisms underlying the irregularities in the pupillary light reflex, such as anisocoria or abnormal responses to light, diagnosis, and treatment of neurological disorders like Horner ’s syndrome, and management of eye movement disorders including one-and-a-half syndrome, vertical gaze palsy, skew deviation and ptosis. The current study also highlighted the limitations of previous studies, including variations in the reported prevalence of the NP, limitations of the histologica l techniques, and inconsistent findings across human an...
Source: Acta Neurologica Belgica - April 7, 2024 Category: Neurology Source Type: research
Headache and cerebral venous sinus thrombosis as a first presentation of mixed connective tissue disease: a rare case and literature review
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 7, 2024 Category: Neurology Source Type: research
Investigations into the anatomical location, physiological function, clinical implications, and significance of the nucleus of Perlia
ConclusionsThe study of the NP holds clinical implications for understanding the neural mechanisms underlying the irregularities in the pupillary light reflex, such as anisocoria or abnormal responses to light, diagnosis, and treatment of neurological disorders like Horner ’s syndrome, and management of eye movement disorders including one-and-a-half syndrome, vertical gaze palsy, skew deviation and ptosis. The current study also highlighted the limitations of previous studies, including variations in the reported prevalence of the NP, limitations of the histologica l techniques, and inconsistent findings across human an...
Source: Acta Neurologica Belgica - April 7, 2024 Category: Neurology Source Type: research
Headache and cerebral venous sinus thrombosis as a first presentation of mixed connective tissue disease: a rare case and literature review
(Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 7, 2024 Category: Neurology Source Type: research
Dalfampridine in the treatment of primary fatigue in patients with multiple sclerosis: a randomized clinical trail
ConclusionThe present study revealed a positive short-term effect of extended-release fampridine on MFIS in PwMS. However, this effect was not significantly superior to the placebo. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 6, 2024 Category: Neurology Source Type: research
Sex differences in Parkinson ’s disease-related non motor symptoms: a focus on sleep problems
AbstractParkinson ’s disease (PD) symptomatology differs between females and males, yet the contribution of sex on sleep problems needs further analysis. Here, we aimed to investigate sex-specific patterns in the relationship between sleep problems, assessed using the Parkinson’s disease sleep scale (PDSS-2), non motor symptoms (NMS), measured by the NMS scale (NMSS), and health-related quality of life (HR-QoL), evaluated by the Parkinson’s disease questionnaire (PDQ-39), in a large cohort of PD patients. One-hundred-fifty-four PD patients were included in the study. Female PD patients (n = 62) exhibi ted a highe...
Source: Acta Neurologica Belgica - April 4, 2024 Category: Neurology Source Type: research
Quantifying abnormal writing kinematics in writer ’s cramp using a novel software platform
ConclusionsUsing the LEKH platform, the kinematic profile of patients with WC could be differentiated from healthy controls. Studies in larger samples will be needed to derive statistical models that can differentiate the flexion and extension types of WC which can help in muscle selection and to quantify the effects of treatment. (Source: Acta Neurologica Belgica)
Source: Acta Neurologica Belgica - April 4, 2024 Category: Neurology Source Type: research
