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Novel heteroplasmic mutation in the anticodon stem of mitochondrial tRNALys associated with dystonia and stroke-like episodesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] The novel A8332G heteroplasmic mutation is most likely a new cause of dystonia and stroke-like episodes due to mitochondrial encephalopathy. The synergistic effect of the G8697A, A11812G and T10463C single nucleotide polymorphisms may modify the phenotype. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 20, 2009 Category: Neurology Authors: A. Gal, K. Pentelenyi, V. Remenyi, Z. Pal, B. Csanyi, G. Tomory, I. Rasko, M. J. Molnar Source Type: journals

White matter disorders with autosomal dominant heredity: a review with personal clinical case studies and their MRI findingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] The diagnosis within the group of leukoencephalopathies thus characterized by MRI relies mainly upon clinical and genetic analysis. The differential diagnosis against treatable leukoencephalopathies is increasingly relevant. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 19, 2009 Category: Neurology Authors: C. Sundal, S. Ekholm, O. Andersen Source Type: journals

Increased cerebrospinal fluid chitotriosidase index in patients with multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] CTTS index is elevated in RRMS and SPMS. The CTTS index is related to CSF markers of inflammation or immune activation. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 19, 2009 Category: Neurology Authors: M. M. Verbeek, E. A. Notting, B. Faas, R. Claessens-Linskens, P. J. H. Jongen Source Type: journals

Multiple sclerosis in the Faroe Islands. 8. Notifiable diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] There is a temporal association of AIGE and paradysentery in the Faroe Islands with the first arrival and later marked augmentation of British forces stationed there during the war. Rises in the incidence of other diseases in 1941[ndash]1942 seem more likely a consequence of increased foreign commercial travel by Faroese at that time. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 19, 2009 Category: Neurology Authors: M. T. Wallin, A. Heltberg, J. F. Kurtzke Source Type: journals

Is there a prognostic role for C-reactive protein in ischemic stroke?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] CRP levels [ge]9 mg/l, evaluated in incident ischemic stroke within 24 h, predict a higher risk of further ischemic events and mortality. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 19, 2009 Category: Neurology Authors: G. Corso, E. Bottacchi, A. Brusa, M. Di Benedetto, G. Giardini, C. Lia, M. Reggiani, M. Veronese Morosini Source Type: journals

Mitoxantrone treatment in multiple sclerosis induces TH2-type cytokinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] Mitoxantrone treatment in MS enhances the inducibility of TH2-type cytokines, which may contribute to its beneficial effects in MS. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 19, 2009 Category: Neurology Authors: A. Vogelgesang, S. Rosenberg, S. Skrzipek, B. M. Bröker, A. Dressel Source Type: journals

Effect of cilnidipine vs losartan on cerebral blood flow in hypertensive patients with a history of ischemic stroke: a randomized controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] This trial failed to prove the non-inferiority of cilnidipine to losartan regarding global CBF change. Both the treatments, however, increase the global CBF despite BP lowering. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 19, 2009 Category: Neurology Authors: K.-S. Hong, D.-W. Kang, H.-J. Bae, Y. K. Kim, M.-K. Han, J.-M. Park, J.-H. Rha, Y.-S. Lee, J.-S. Koo, Y.-J. Cho, S. U. Kwon, S. E. Kim, S.-H. Park Source Type: journals

Intravenous recombinant tissue plasminogen activator for acute stroke in Poland: an analysis based on the Safe Implementation of Thrombolysis in Stroke (SITS) RegistryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] Because of higher mortality the study implies the need to improve the organization of thrombolysis services and provides the rationale to continue the monitoring of treatment in Poland. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 17, 2009 Category: Neurology Authors: A. Kobayashi, A. Czlonkowska, N. Ahmed, S. Romanowicz, M. Glonek, W. M. Nyka, G. Opala, N. Wahlgren Source Type: journals

The effect of statin therapy on the progression of carotid artery stenosis in relation to stenosis severityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] Treatment with statins already in early stages of ICA stenosis might delay the progression and even reverse the degree of stenosis. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 16, 2009 Category: Neurology Authors: O. Hegland, M. W. Kurz, P. S. Munk, J. P. Larsen Source Type: journals

Cerebellar apparent diffusion coefficient changes in patients with supratentorial ischemic strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] Supratentorial ischemic stroke may cause mild cerebellar vasogenic edema. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 16, 2009 Category: Neurology Authors: Y. Liu, J. Nuutinen, M. P. Laakso, J. O. Karonen, M. Könönen, E. Vanninen, J. T. Kuikka, R. L. Vanninen Source Type: journals

Multiple sclerosis in a family on the Faroe IslandsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] This research questions Kurtzke's theory as three of the cases do not conform to the epidemic cohorts described. Furthermore, there appears to be a higher than usual prevalence of PPMS. The high degree of heterogeneity of the HLA types carried indicates that HLA alleles do not independently explain the risk of developing MS. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 16, 2009 Category: Neurology Authors: S. Binzer, K. Imrell, M. Binzer, S. Vang, B. Rogvi-Hansen, J. Hillert, E. Stenager Source Type: journals

Idiopathic generalized epilepsies: a follow-up study in a single-centerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] Most of patients with IGEs can be successfully treated with monotherapy. Refractory seizures in some patients may be because of avoidable factors, especially in young women. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 16, 2009 Category: Neurology Authors: E. Kharazmi, M. Peltola, M. Fallah, T. Keränen, J. Peltola Source Type: journals

Comment on the Letter to the Editor by Professor ReiberEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - November 4, 2009 Category: Neurology Authors: B. Arneth Source Type: journals

Free light chains in CSF – pushing a method with biased interpretationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 31, 2009 Category: Neurology Authors: Hansotto Reiber Source Type: journals

Author's Response to Professor Reiber's second letter concerning our article: High sensitivity of free lambda and free kappa light chains for the detection of intrathecal immunoglobulin synthesis in cerebrospinal fluidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 30, 2009 Category: Neurology Authors: Borros Arneth Source Type: journals

Validity of the Danish Prostate Symptom Score questionnaire in strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] The DAN-PSS-1 questionnaire appears to be content and face valid for measuring lower urinary tract symptoms after stroke. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 19, 2009 Category: Neurology Authors: S. Tibaek, C. Dehlendorff Source Type: journals

Focal clinical and electroencephalographic features in patients with juvenile myoclonic epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] Patients with JME showed focal clinical and EEG features. These features should not be misinterpreted as indicative of partial epilepsy. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 18, 2009 Category: Neurology Authors: S. S. Jayalakshmi, B. Srinivasa Rao, S. Sailaja Source Type: journals

Circadian rhythm of stroke onset during the month of RamadanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] A significant shift of the circadian pattern of stroke onset time from the period between 6:00 a.m. and noon to that between noon and 6:00 pm has been found during the month of Ramadan. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 14, 2009 Category: Neurology Authors: A. El-Mitwalli, A. A. Zaher, E. El Menshawi Source Type: journals

Assessment of post-stroke extrapersonal neglect using a three-dimensional immersive virtual street crossing programEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] Post-stroke neglect in the extrapersonal space can be easily and safely detected and measured using our three-dimensional immersive virtual street crossing program. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 14, 2009 Category: Neurology Authors: D. Y. Kim, J. Ku, W. H. Chang, T. H. Park, J. Y. Lim, K. Han, I. Y. Kim, S. I. Kim Source Type: journals

A patients state of health (disease) is a quality which defines relevance of a molecular variation, not vice versaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 8, 2009 Category: Neurology Authors: H. Reiber Source Type: journals

Low frequency of VHL germline mutations in Norwegian patients presenting with isolated central nervous system hemangioblastomas – a population-based studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] von Hippel-Lindau disease anchored in germline mutations of the VHL gene is rare in the Norwegian population as opposed to clinical VHL disease, which appears to be relatively common in patients with apparently sporadic hemangioblastomas. There exists insufficient data regarding the natural history of patients with renal cysts, which makes it difficult to include or disregard these lesions as an entity of VHL disease. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 7, 2009 Category: Neurology Authors: P. Rønning, P. A. Andresen, J. K. Hald, K. Heimdal, D. Scheie, T. Schreiner, E. Helseth Source Type: journals

Cerebrospinal fluid outflow and intracranial pressure in hydrocephalic patients with external ventricular drainageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] The study stresses the important inter and intra-subject variability of Q'extcsf in patients with EVD. The mean Q'extcsf is lower than the reference production rate (21 ml/h), raising the question of persistent CSF absorption and/or depressed secretion. The independent changes of Q'extcsf and ICP on the short term is likely to be explained by the pressure[ndash]volume characteristics of the intracranial space. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 7, 2009 Category: Neurology Authors: O. Klein, B. Demoulin, R. T. Jean Auque, G. Audibert, C. Sainte-Rose, J.-C. Marchal, F. Marchal Source Type: journals

Outcome prediction in traumatic brain injury: comparison of neurological status, CT findings, and blood levels of S100B and GFAPEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] Blood levels of S100B and GFAP indicate the severity of brain damage and are correlated with neurological prognosis after trauma. Both methods can yield additional prognostic information if combined with clinical and CCT findings. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 4, 2009 Category: Neurology Authors: M. Wiesmann, E. Steinmeier, O. Magerkurth, J. Linn, D. Gottmann, U. Missler Source Type: journals

Drug-induced confusional states: the usual suspects?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] The data suggest that diuretics by way of causing hyponatraemia are as relevant a cause of ACS as dopaminergic or anticholinergic substances. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 4, 2009 Category: Neurology Authors: A. Hufschmidt, V. Shabarin, T. Zimmer Source Type: journals

Endothelial nitric oxide synthase Glu298Asp, 4b/a, and −786T>C gene polymorphisms and the risk of ischemic strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] Genetic variation at the eNOS locus represent genetic risk factor for increased susceptibility to IS. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 4, 2009 Category: Neurology Authors: S. Saidi, S. G. Mallat, W. Y. Almawi, T. Mahjoub Source Type: journals

In vitro neurotoxic properties and excitatory aminoacids concentration in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. Relationship with the degree of certainty of disease diagnosesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] Glutamate but not aspartate CSF levels may contribute to ALS pathogenesis. However, glutamate levels may not influence the degree of diagnosis certainty or lesion extension. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 4, 2009 Category: Neurology Authors: M. L. Fiszman, K. C. Ricart, A. Latini, G. Rodríguez, R. E. P. Sica Source Type: journals

Leptin and the metabolic syndrome in patients with myotonic dystrophy type 1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] The leptin overproduction correlated with insulin resistance in DM1 patients but the significance of this finding remains unclear. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 4, 2009 Category: Neurology Authors: V. Rakocevic Stojanovic, S. Peric, D. Lavrnic, S. Popovic, T. Ille, Z. Stevic, I. Basta, S. Apostolski Source Type: journals

Mitral valve prolapse and abnormalities of haemostasis in children and adolescents with migraine with aura and other idiopathic headaches: a pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] A proportion, at least, of the MA patients showed a more complex phenotype characterized by MVP and/or positive aCL titres. The pathogenetic role of these associations is obscure and larger studies are needed to confirm the usefulness of echocardiographic and laboratory investigations in this area and to identify possible new treatment approaches that might be explored in this group of MA patients. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 4, 2009 Category: Neurology Authors: C. Termine, R. Trotti, P. Ondei, G. Gamba, N. Montani, A. Gamba, M. De Simone, E. Marni, U. Balottin Source Type: journals

Less protease-resistant PrP in a patient with sporadic CJD treated with intraventricular pentosan polysulphateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 68-year-old woman with sporadic Creutzfeldt[ndash]Jakob disease who received continuous intraventricular PPS infusion (1[ndash]120 [mu]g/kg/day) for 17 months starting 10 months after the onset of clinical symptoms. Treatment with PPS was well tolerated but was associated with a minor, transient intraventricular hemorrhage and a non-progressive collection of subdural fluid. The patient's overall survival time was well above the mean time expected for the illness but still within the normal range. Post-mortem examination revealed that the level of abnormal protease-resistant prion protein in the brain was marked...
Source: Acta Neurologica Scandinavica - October 4, 2009 Category: Neurology Authors: T. Terada, Y. Tsuboi, T. Obi, K. Doh-ura, S. Murayama, T. Kitamoto, T. Yamada, K. Mizoguchi Source Type: journals

Hyperdense middle cerebral artery sign is an ominous prognostic marker despite optimal workflowEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] Despite optimal workflow, patients with HMCAS showed poor outcome after intravenous thrombolysis. The results emphasize the urgent need for more effective revascularization therapies and neuroprotective treatment in this subgroup of stroke patients. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 4, 2009 Category: Neurology Authors: K. Abul-Kasim, M. Brizzi, J. Petersson Source Type: journals

Opinion of Belgian neurologists on antiepileptic drug treatment in 2006: Belgian study on epilepsy treatment (BESET-2)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] In end 2006, carbamazepine, valproate and oxcarbazepine were considered to be first choice drugs, whereas other newer drugs, like lamotrigine, levetiracetam and topiramate were predominantly prescribed in second line. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 4, 2009 Category: Neurology Authors: B. Legros, P. Boon, P. De Jonghe, B. Sadzot, K. Van Rijckevorsel, E. Schmedding Source Type: journals

Tactile direction discrimination and vibration detection in diabetic neuropathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] TDD seems more useful than vibration detection in examination of diabetic neuropathy. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 4, 2009 Category: Neurology Authors: L. S. Löken, L. C. Lundblad, M. Elam, H. W. Olausson Source Type: journals

ApolipoproteinE epsilon 4 allele is not associated with disease course and severity in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] Although plausible, the association between APOE and MS course (particularly with BMS defined by including cognitive preservation) and disease severity remains controversial. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 4, 2009 Category: Neurology Authors: E. Portaccio, V. Zipoli, B. Goretti, B. Hakiki, B. Nacmias, G. Siracusa, S. Sorbi, M. P. Amato Source Type: journals

Evaluation of multiple sclerosis diagnostic criteria in Suzhou, China – risk of under-diagnosis in a low prevalence areaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] Under-diagnosis of MS could be one of the explanations for the low prevalence of MS in China. Compared to the Poser criteria, the McDonald criteria had a higher sensitivity for the diagnosis of MS. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 4, 2009 Category: Neurology Authors: X.-J. Cheng, Q. Cheng, L.-Z. Xu, H.-Q. Zhao, Z. Zhao, W. Wang, G.-X. Jiang, S. Fredrikson Source Type: journals

Serum heme oxygenase-1 levels are increased in Parkinson's disease but not in Alzheimer's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] The increase of serum HO-1 levels in PD patients could indicate a systemic antioxidant reaction related to a chronic oxidative stress state in PD brain. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - September 23, 2009 Category: Neurology Authors: I. Mateo, J. Infante, P. Sánchez-Juan, I. García-Gorostiaga, E. Rodríguez-Rodríguez, J. L. Vázquez-Higuera, J. Berciano, O. Combarros Source Type: journals

The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] AQT processing speed, ADAS-Cog, and MMSE measures proved stable during the second 6 months of treatment with AChEI. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - September 23, 2009 Category: Neurology Authors: E. H. Wiig, P. Annas, H. Basun, N. Andreasen, L. Lannfelt, H. Zetterberg, K. Blennow, L. Minthon Source Type: journals

Anal sphincter EMG in the diagnosis of parkinsonian syndromesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] Abnormal EMG of the EAS is strongly suggestive of atypical parkinsonism and the pathophysiology may be different in patients with MSA and PSP. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - September 23, 2009 Category: Neurology Authors: K. Winge, P. Jennum, A. Lokkegaard, L. Werdelin Source Type: journals

Hematopoietic stem cell transplantation in multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rogojan C, Frederiksen JL. Hematopoietic stem cell transplantation in multiple sclerosis.Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2009.01168.x.© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Intensive immunosuppresion followed by hematopoietic stem cell transplantation (HSCT) has been suggested as potential treatment in severe forms of multiple sclerosis (MS). Since 1995 ca. 400 patients have been treated with HSCT. Stabilization or improvement occurred in almost 70% of cases at least for 3 years post-transplant. Magnetic resonance revealed the capacity of autologous HSCT to suppress or markedly re...
Source: Acta Neurologica Scandinavica - September 23, 2009 Category: Neurology Authors: C. Rogojan, J. L. Frederiksen Source Type: journals

Levetiracetam monotherapy for childhood occipital epilepsy of gastautEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion [ndash] Monotherapy with LEV was effective and well tolerated in patients with COE-G. Nevertheless, prospective, large, long-term double-blind studies are needed to confirm these findings. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - September 14, 2009 Category: Neurology Authors: A. Verrotti, P. Parisi, G. Loiacono, A. Mohn, S. Grosso, P. Balestri, E. Tozzi, P. Iannetti, F. Chiarelli, P. Curatolo Source Type: journals

Is there a need for long-term follow-up in chronic idiopathic polyneuropathy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] Patients with CIP and GBS seem to develop persistent impairment on long-term functional status and well-being, more clearly in CIP, reflecting the importance of long-term follow-up in further disease management. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - September 10, 2009 Category: Neurology Authors: T. Rudolph, J. P. Larsen, E. Farbu Source Type: journals

The combinations of TNFα–308 and IL-6 –174 or IL-10 –1082 genes polymorphisms suggest an association with susceptibility to sporadic late-onset Alzheimer's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] Our results suggest that TNF[alpha] and IL-10 promoter polymorphism might be a risk factor for AD. The combined effects of TNF[alpha][ndash]308, IL-6 [ndash]174 and IL-10 [ndash]1082 variant alleles may be more decisive to induce functional differences and modify the risk for AD. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - September 9, 2009 Category: Neurology Authors: P. Vural, S. Değirmencioğlu, H. Parıldar-Karpuzoğlu, S. Doğru-Abbasoğlu, H. A. Hanagasi, B. Karadağ, H. Gürvit, M. Emre, M. Uysal Source Type: journals

Parkinson's disease and hospital admissions: frequencies, diagnoses and costsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] Hospitalization in PD does not induce incremental costs. The diagnoses causing hospital admissions were different in patients with PD as compared with controls. Our results indicate that cancer and vascular diseases might be less common in patients with PD than in the general population. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - September 9, 2009 Category: Neurology Authors: C. Vossius, O. B. Nilsen, J. P. Larsen Source Type: journals

A novel mutation in the mitochondrial tRNA for tryptophan causing a late-onset mitochondrial encephalomyopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with a late-onset mitochondrial encephalomyopathy caused by a novel G > C transition in mtDNA at position 5556 in the gene encoding the tRNA for tryptophan (MTTW).Aims [ndash] To investigate the cause of disease and assess the pathogenicity of this new mutation.Methods [ndash] Clinical, histopathological and gene sequencing studies. Quantification of the mutation was performed in different tissues from the patient and two relatives and in single muscle fibres.Results [ndash] The mutation was heteroplasmic, segregated in biochemically affected muscle fibres and was absent in blood. The level of mutation ...
Source: Acta Neurologica Scandinavica - September 9, 2009 Category: Neurology Authors: P. S. Sanaker, H. L. Nakkestad, E. Downham, L. A. Bindoff Source Type: journals

CTLA4 exon 1 and promoter polymorphisms in patients with multiple sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] After Bonferroni correction, the results provide preliminary evidence that CTLA4 genetic variation at [minus]1661 locus may render Iranian individuals to be more susceptible to MS, whereas harboring TACA haplotype might be protective. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - September 7, 2009 Category: Neurology Authors: G. Yousefipour, N. Erfani, M. Momtahan, H. Moghaddasi, A. Ghaderi Source Type: journals

Intracranial tumor surgery in patients >70 years of age: is clinical practice worthwhile or futile?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] Surgery for intracranial tumors in selected elderly patients is worthwhile, not futile. Age alone should not be used as a selection criterion for treatment. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - September 7, 2009 Category: Neurology Authors: S. G. Rogne, A. Konglund, T. R. Meling, D. Scheie, T. B. Johannesen, P. Rønning, E. Helseth Source Type: journals

Parvalbumin-, calbindin-, and calretinin-immunoreactive hippocampal interneuron density in autismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigates the density of subsets of hippocampal interneurons, immunostained with the calcium binding proteins, calbindin (CB), calretinin (CR) and parvalbumin (PV) to determine whether specific subpopulations of interneurons are impacted in autism.Materials and methods [ndash] Unbiased stereological techniques were used to quantify the neuronal density of these immunoreactive subpopulations of gamma-aminobutyric acid-ergic (GABAergic) interneurons analyzed in the CA and subicular fields in postmortem brain material obtained from five autistic and five age-, gender- and postmortem interval-matched control case...
Source: Acta Neurologica Scandinavica - August 30, 2009 Category: Neurology Authors: Y. A. Lawrence, T. L. Kemper, M. L. Bauman, G. J. Blatt Source Type: journals

Long-term effect of repetitive transcranial magnetic stimulation on motor function recovery after acute ischemic strokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion [ndash] These results confirm that real rTMS over motor cortex can enhance and maintain recovery and may be a useful add on therapy in treatment of acute stroke patients. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - August 11, 2009 Category: Neurology Authors: E. M. Khedr, A. E. Etraby, M. Hemeda, A. M. Nasef, A. A. E. Razek Source Type: journals

Long-term outcome after surgery for Chiari I malformationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] More than three-quarters of the patients still considered their situation improved at long-term follow-up after surgery. These results support surgical intervention in symptomatic Chiari I patients. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - June 11, 2009 Category: Neurology Authors: M. Tisell, J. Wallskog, M. Linde Source Type: journals

Changes in ability, perceived difficulty and use of assistive devices in everyday life: a 4-year follow-up study in people with late effects of polioEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] Over 4 years, more persons perceived difficulties and the use of assistive devices increased. This is might reflect adaptation and acknowledgement of problems previously ignored. Time is a factor in integrating knowledge and adaptation. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - June 10, 2009 Category: Neurology Authors: A.-L. Thorén-Jönsson, C. Willén, K. S. Sunnerhagen Source Type: journals

Association between human herpesvirus 6 and occurrence of multiple sclerosis among Jordanian patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] Although these results indicate lack of apparent association between HHV-6 to MS among Jordanian patients, heterogeneity related to genetic polymorphism as well as geographical distribution of the disease and of pathogens may be of significance. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - June 10, 2009 Category: Neurology Authors: M. Ahram, A. El-Omar, Y. Baho, M. A. Lubad Source Type: journals