Acta Neurologica Scandinavica. Supplementum This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Introduction.
PMID: 26046551 [PubMed - in process] (Source: Acta Neurologica Scandinavica. Supplementum)
Source: Acta Neurologica Scandinavica. Supplementum - June 10, 2015 Category: Neurology Authors: Andersen O Tags: Acta Neurol Scand Suppl Source Type: research

Registers of multiple sclerosis in Denmark.
Abstract There are two nationwide population-based registers for multiple sclerosis (MS) in Denmark. The oldest register is The Danish Multiple Sclerosis Registry (DMSR), which is an epidemiological register for estimation of prevalence and incidence of MS and survival, and for identifying exposures earlier in life that may affect the risk of MS. This register has no systematic follow-up data except for survival. The DMSR has over the years published nationwide incidence- and prevalence data from Denmark and has been involved in a number of 'historical prospective' studies to elucidate the association betw...
Source: Acta Neurologica Scandinavica. Supplementum - June 10, 2015 Category: Neurology Authors: Koch-Henriksen N, Magyari M, Laursen B Tags: Acta Neurol Scand Suppl Source Type: research

The Swedish MS registry - clinical support tool and scientific resource.
Abstract The Swedish MS registry (SMSreg) is designed to assure quality health care for patients with multiple sclerosis (MS). It has been active since 2001 and web-based since 2004. It runs on government funding only and is used in all Swedish neurology departments. The SMSreg currently includes data on 14,500 of Sweden's estimated 17,500 prevalent patients with MS. One important function of SMSreg, to which participation is voluntary, is to serve as a tool for decision support and to provide an easy overview of the patient information needed at clinical visits. This is its core feature and explains why t...
Source: Acta Neurologica Scandinavica. Supplementum - June 10, 2015 Category: Neurology Authors: Hillert J, Stawiarz L Tags: Acta Neurol Scand Suppl Source Type: research

Role of socio-economic and reproductive factors in the risk of multiple sclerosis.
This study database included all multiple sclerosis cases (n = 1403) from the Danish MS Registry with clinical onset between 2000 and 2004 as well as 35,045 controls drawn by random from the Danish Civil Registration System and matched by sex year of birth and residential municipality at the reference year. Having newborn children reduced the risk of multiple sclerosis (MS) in women but not in men. Childbirths reduced the risk of MS by about 46% during the following 5 years. Even pregnancies terminated early had a protective effect on the risk of developing MS suggesting a temporary immunosuppression during pregnancy. O...
Source: Acta Neurologica Scandinavica. Supplementum - June 10, 2015 Category: Neurology Authors: Magyari M Tags: Acta Neurol Scand Suppl Source Type: research

The Norwegian Multiple Sclerosis Registry and Biobank.
Abstract Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system with unknown cause and various benefits from disease modifying therapies. Systematic recording of data into national MS registries is therefore needed to optimize treatment and define the pathogenesis of the disease. The Norwegian MS Registry and Biobank was established for systematic collection of clinical and epidemiological data, as well as biological samples. Data collection is based on informed consent from the individual patients and recordings by treating neurologists. All researchers have, by applicatio...
Source: Acta Neurologica Scandinavica. Supplementum - June 10, 2015 Category: Neurology Authors: Myhr KM, Grytten N, Torkildsen Ø, Wergeland S, Bø L, Aarseth JH Tags: Acta Neurol Scand Suppl Source Type: research

Time trends in the incidence and prevalence of multiple sclerosis in Norway during eight decades.
The objective of this study was to review the studies on the prevalence and incidence of MS in Norway, provide an update on the prevalence of MS in Norway, and describe the time trends in the prevalence and incidence of MS in relation to risk factors, case ascertainment, and data. We performed a systematic search on PubMed and MEDLINE up to November 2014 using the search string 'multiple sclerosis prevalence in Norway' or 'multiple sclerosis incidence in Norway'. In addition, we scrutinized the reference lists of the publications identified for relevant citations. We retrieved data on the distribution of MS in Norway on De...
Source: Acta Neurologica Scandinavica. Supplementum - June 10, 2015 Category: Neurology Authors: Grytten N, Torkildsen Ø, Myhr KM Tags: Acta Neurol Scand Suppl Source Type: research

Socio-economic factors and immigrant population studies of multiple sclerosis.
Abstract The uneven geographical distribution of multiple sclerosis (MS) and the differences in disease severity observed between different ethnic groups indicate a complex interplay between genetic and environmental risk factors involved in the disease pathogenesis. Changes in MS risk after migration suggest influence of environmental factors on disease susceptibility. Whether the risk of MS is affected by socio-economic status (SES) is still controversial. In the present review, the combined knowledge from studies of migration and SES in MS is discussed. PMID: 26046557 [PubMed - in process] (Sou...
Source: Acta Neurologica Scandinavica. Supplementum - June 10, 2015 Category: Neurology Authors: Berg-Hansen P, Celius EG Tags: Acta Neurol Scand Suppl Source Type: research

Does the changing sex ratio of multiple sclerosis give opportunities for intervention?
Abstract In several international studies, an increasing women-to-men (w/m) ratio in patients with multiple sclerosis (MS) has been reported. Such sex ratios have been analysed by year of onset or by year of birth. In a Swedish study, data from the Swedish MS register (SMSreg) were used to analyse the w/m ratio in Sweden. The sex ratio was analysed both by year of birth (8834 patients) and by year of onset (9098 patients). No increased w/m ratio was seen in this study. The age-specific sex ratio did not demonstrate any significant changes. However, a new investigation of the sex ratio in Sweden, based on d...
Source: Acta Neurologica Scandinavica. Supplementum - June 10, 2015 Category: Neurology Authors: Boström I, Landtblom AM Tags: Acta Neurol Scand Suppl Source Type: research

Multiple sclerosis and environmental factors: the role of vitamin D, parasites, and Epstein-Barr virus infection.
Abstract Pathogenic mechanisms underlying multiple sclerosis development have yet to be clearly identified, but considerable evidence indicates that autoimmunity plays an important role in the etiology of the disease. It is generally accepted that autoimmune diseases like MS arise from complex interactions between genetic susceptibility and environmental factors. Although environmental factors unequivocally influencing MS development have yet to be established, accumulating evidence singles out several candidates, including sunlight-UV exposure or vitamin D deficiency, viral infections, hygiene, and cigare...
Source: Acta Neurologica Scandinavica. Supplementum - June 10, 2015 Category: Neurology Authors: Correale J, Gaitán MI Tags: Acta Neurol Scand Suppl Source Type: research

Vitamin D and multiple sclerosis-from epidemiology to prevention.
Abstract In the present review, we discuss observational and experimental data suggesting a protective effect from sun exposure and/or vitamin D in multiple sclerosis (MS). These data include geographic variations in MS occurrence, temporal trends, genetics, biobank, and questionnaire data. We look more closely at the differentiation between general effects from UV exposure, and those of vitamin D per se, including plausible mechanisms of action. Finally, primary prevention is touched upon, and we suggest actions to be taken while awaiting the results from ongoing randomized controlled trials with vitamin ...
Source: Acta Neurologica Scandinavica. Supplementum - June 10, 2015 Category: Neurology Authors: Sundström P, Salzer J Tags: Acta Neurol Scand Suppl Source Type: research

Hormonal and gender-related immune changes in multiple sclerosis.
Abstract Similarly to many other autoimmune diseases, multiple sclerosis (MS) is more common among women than men, and its incidence among women is rising. There are also qualitative differences in the disease course between men and women, with male patients experiencing increased disease progression, brain atrophy, and cognitive impairment. During pregnancy, women with MS typically have a greatly reduced relapse rate, whereas very soon after the delivery, the disease activity returns, often even at a higher level than seen in the prepregnancy year. The reasons for the increased postpartum activity are not...
Source: Acta Neurologica Scandinavica. Supplementum - June 10, 2015 Category: Neurology Authors: Airas L Tags: Acta Neurol Scand Suppl Source Type: research

Conclusion: National incidence and risk factor assessments may become a basis for the evaluation of prevention trials - prospects from the Third Nordic MS Symposium.
Abstract This symposium started with an overview of recent incidence and prevalence data from the Scandinavian national registers and continued with a critical analysis of several alleged risk factors for MS. These risk factors are constantly changing and therefore might explain current incidence changes. In addition, they may be the subject of preventive measures. PMID: 26046562 [PubMed - in process] (Source: Acta Neurologica Scandinavica. Supplementum)
Source: Acta Neurologica Scandinavica. Supplementum - June 10, 2015 Category: Neurology Authors: Andersen O Tags: Acta Neurol Scand Suppl Source Type: research

Neurological disorders in the Global Burden of Disease 2010 study.
CONCLUSIONS: Neurological disorders are of great public health importance. This knowledge is useful in dimensioning and organizing healthcare systems and necessary when planning education of health personnel on all levels. PMID: 24588499 [PubMed - in process] (Source: Acta Neurologica Scandinavica. Supplementum)
Source: Acta Neurologica Scandinavica. Supplementum - March 9, 2014 Category: Neurology Authors: Stovner LJ, Hoff JM, Svalheim S, Gilhus NE Tags: Acta Neurol Scand Suppl Source Type: research

Clinical and genetic studies in a family with a novel mutation in the sepiapterin reductase gene.
CONCLUSIONS: A new homozygous mutation in the SPR gene was found in two sisters with dopa-responsive dystonia. This important and treatable neurotransmitter disorder must be considered in patients with a complex movement disorder with diurnal fluctuations with or without intellectual impairment. Patients with these symptoms should undergo levodopa trial, cerebrospinal fluid investigations, and genetic analyses. PMID: 24588500 [PubMed - in process] (Source: Acta Neurologica Scandinavica. Supplementum)
Source: Acta Neurologica Scandinavica. Supplementum - March 9, 2014 Category: Neurology Authors: Koht J, Rengmark A, Opladen T, Bjørnarå KA, Selberg T, Tallaksen CM, Blau N, Toft M Tags: Acta Neurol Scand Suppl Source Type: research

Dystonia - new advances in classification, genetics, pathophysiology and treatment.
Abstract Dystonia is a heterogeneous movement disorder and has been defined as 'a syndrome of sustained muscle contractions, frequently causing twisted and repetitive movements, or abnormal postures'. The classification of dystonia has developed along with increasing knowledge, and different schemes have been suggested, including age at onset, body distribution, and etiology as the main differentiating factors. A revised definition and a new classification of dystonia have now been proposed by a group of leading dystonia experts and will be referred here. The discovery of the first two gene mutations causi...
Source: Acta Neurologica Scandinavica. Supplementum - March 9, 2014 Category: Neurology Authors: Skogseid IM Tags: Acta Neurol Scand Suppl Source Type: research