Advancing cancer immunotherapy through siRNA-based gene silencing for immune checkpoint blockade
Adv Drug Deliv Rev. 2024 Apr 14:115306. doi: 10.1016/j.addr.2024.115306. Online ahead of print.ABSTRACTCancer immunotherapy represents a revolutionary strategy, leveraging the patient's immune system to inhibit tumor growth and alleviate the immunosuppressive effects of the tumor microenvironment (TME). The recent emergence of immune checkpoint blockade (ICB) therapies, particularly following the first approval of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitors like ipilimumab, has led to significant growth in cancer immunotherapy. The extensive explorations on diverse immune checkpoint antibodies have broa...
Source: Advanced Drug Delivery Reviews - April 16, 2024 Category: Drugs & Pharmacology Authors: Youngjin Choi Su Hyun Seok Hong Yeol Yoon Ju Hee Ryu Ick Chan Kwon Source Type: research
A new era of targeting cystic fibrosis with non-viral delivery of genomic medicines
Adv Drug Deliv Rev. 2024 Apr 14:115305. doi: 10.1016/j.addr.2024.115305. Online ahead of print.ABSTRACTCystic fibrosis (CF) is a complex genetic respiratory disorder that necessitates innovative gene delivery strategies to address the mutations in the gene. This review delves into the promises and challenges of non-viral gene delivery for CF therapy and explores strategies to overcome these hurdles. Several emerging technologies and nucleic acid cargos for CF gene therapy are discussed. Novel formulation approaches including lipid and polymeric nanoparticles promise enhanced delivery through the CF mucus barrier, augmentin...
Source: Advanced Drug Delivery Reviews - April 16, 2024 Category: Drugs & Pharmacology Authors: Namratha Turuvekere Vittala Murthy Kseniia Vlasova Jonas Renner Antony Jozic Gaurav Sahay Source Type: research
Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery
Adv Drug Deliv Rev. 2024 Apr 9;209:115304. doi: 10.1016/j.addr.2024.115304. Online ahead of print.ABSTRACTThe lymphatic system has garnered significant attention in drug delivery research due to the advantages it offers, such as enhancing systemic exposure and enabling lymph node targeting for nanomedicines via the lymphatic delivery route. The journey of drug carriers involves transport from the administration site to the lymphatic vessels, traversing the lymph before entering the bloodstream or targeting specific lymph nodes. However, the anatomical and physiological barriers of the lymphatic system play a pivotal role i...
Source: Advanced Drug Delivery Reviews - April 10, 2024 Category: Drugs & Pharmacology Authors: Yisi Tang Bao Liu Yuting Zhang Yuling Liu Yongzhuo Huang Wufa Fan Source Type: research
Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery
Adv Drug Deliv Rev. 2024 Apr 9;209:115304. doi: 10.1016/j.addr.2024.115304. Online ahead of print.ABSTRACTThe lymphatic system has garnered significant attention in drug delivery research due to the advantages it offers, such as enhancing systemic exposure and enabling lymph node targeting for nanomedicines via the lymphatic delivery route. The journey of drug carriers involves transport from the administration site to the lymphatic vessels, traversing the lymph before entering the bloodstream or targeting specific lymph nodes. However, the anatomical and physiological barriers of the lymphatic system play a pivotal role i...
Source: Advanced Drug Delivery Reviews - April 10, 2024 Category: Drugs & Pharmacology Authors: Yisi Tang Bao Liu Yuting Zhang Yuling Liu Yongzhuo Huang Wufa Fan Source Type: research
Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery
Adv Drug Deliv Rev. 2024 Apr 9;209:115304. doi: 10.1016/j.addr.2024.115304. Online ahead of print.ABSTRACTThe lymphatic system has garnered significant attention in drug delivery research due to the advantages it offers, such as enhancing systemic exposure and enabling lymph node targeting for nanomedicines via the lymphatic delivery route. The journey of drug carriers involves transport from the administration site to the lymphatic vessels, traversing the lymph before entering the bloodstream or targeting specific lymph nodes. However, the anatomical and physiological barriers of the lymphatic system play a pivotal role i...
Source: Advanced Drug Delivery Reviews - April 10, 2024 Category: Drugs & Pharmacology Authors: Yisi Tang Bao Liu Yuting Zhang Yuling Liu Yongzhuo Huang Wufa Fan Source Type: research
Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery
Adv Drug Deliv Rev. 2024 Apr 9;209:115304. doi: 10.1016/j.addr.2024.115304. Online ahead of print.ABSTRACTThe lymphatic system has garnered significant attention in drug delivery research due to the advantages it offers, such as enhancing systemic exposure and enabling lymph node targeting for nanomedicines via the lymphatic delivery route. The journey of drug carriers involves transport from the administration site to the lymphatic vessels, traversing the lymph before entering the bloodstream or targeting specific lymph nodes. However, the anatomical and physiological barriers of the lymphatic system play a pivotal role i...
Source: Advanced Drug Delivery Reviews - April 10, 2024 Category: Drugs & Pharmacology Authors: Yisi Tang Bao Liu Yuting Zhang Yuling Liu Yongzhuo Huang Wufa Fan Source Type: research
Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery
Adv Drug Deliv Rev. 2024 Apr 9;209:115304. doi: 10.1016/j.addr.2024.115304. Online ahead of print.ABSTRACTThe lymphatic system has garnered significant attention in drug delivery research due to the advantages it offers, such as enhancing systemic exposure and enabling lymph node targeting for nanomedicines via the lymphatic delivery route. The journey of drug carriers involves transport from the administration site to the lymphatic vessels, traversing the lymph before entering the bloodstream or targeting specific lymph nodes. However, the anatomical and physiological barriers of the lymphatic system play a pivotal role i...
Source: Advanced Drug Delivery Reviews - April 10, 2024 Category: Drugs & Pharmacology Authors: Yisi Tang Bao Liu Yuting Zhang Yuling Liu Yongzhuo Huang Wufa Fan Source Type: research
Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery
Adv Drug Deliv Rev. 2024 Apr 8:115304. doi: 10.1016/j.addr.2024.115304. Online ahead of print.ABSTRACTThe lymphatic system has garnered significant attention in drug delivery research due to the advantages it offers, such as enhancing systemic exposure and enabling lymph node targeting for nanomedicines via the lymphatic delivery route. The journey of drug carriers involves transport from the administration site to the lymphatic vessels, traversing the lymph before entering the bloodstream or targeting specific lymph nodes. However, the anatomical and physiological barriers of the lymphatic system play a pivotal role in in...
Source: Advanced Drug Delivery Reviews - April 10, 2024 Category: Drugs & Pharmacology Authors: Yisi Tang Bao Liu Yuting Zhang Yuling Liu Yongzhuo Huang Wufa Fan Source Type: research
Delivery technologies for therapeutic targeting of fibronectin fibrosis in autoimmunity and applications
Adv Drug Deliv Rev. 2024 Apr 6:115303. doi: 10.1016/j.addr.2024.115303. Online ahead of print.ABSTRACTFibronectin (FN) is a critical component of extracellular matrix (ECM) contributing to various physiological processes, including tissue repair and immune response regulation. FN regulates various cellular functions such as adhesion, proliferation, migration, differentiation, and cytokine release. Alterations in FN expression, deposition, and molecular structure can profoundly impact its interaction with cells, growth factors, ECM components, and associated signaling pathways, thus influencing the progress of diseases such...
Source: Advanced Drug Delivery Reviews - April 8, 2024 Category: Drugs & Pharmacology Authors: Jacob D Bonadio Ghazal Bashiri Patrick Halligan Michael Kegel Fatima Ahmed Karin Wang Source Type: research
Delivery technologies for therapeutic targeting of fibronectin fibrosis in autoimmunity and applications
Adv Drug Deliv Rev. 2024 Apr 6:115303. doi: 10.1016/j.addr.2024.115303. Online ahead of print.ABSTRACTFibronectin (FN) is a critical component of extracellular matrix (ECM) contributing to various physiological processes, including tissue repair and immune response regulation. FN regulates various cellular functions such as adhesion, proliferation, migration, differentiation, and cytokine release. Alterations in FN expression, deposition, and molecular structure can profoundly impact its interaction with cells, growth factors, ECM components, and associated signaling pathways, thus influencing the progress of diseases such...
Source: Advanced Drug Delivery Reviews - April 8, 2024 Category: Drugs & Pharmacology Authors: Jacob D Bonadio Ghazal Bashiri Patrick Halligan Michael Kegel Fatima Ahmed Karin Wang Source Type: research
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics
Adv Drug Deliv Rev. 2024 Apr 3;208:115302. doi: 10.1016/j.addr.2024.115302. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a significant global health challenge. Consequently, the development of innovative therapeutic strategies to enhance CVDs treatment is imperative. RNA-based therapies, encompassing non-coding RNAs, mRNA, aptamers, and CRISPR/Cas9 technology, have emerged as promising tools for addressing CVDs. However, inherent challenges associated with RNA, such as poor cellular uptake, susceptibility to RNase degradation, and capture by the reticulo...
Source: Advanced Drug Delivery Reviews - April 4, 2024 Category: Drugs & Pharmacology Authors: Paula Gil-Cabrerizo Teresa Simon-Yarza Elisa Garbayo Mar ía J Blanco Prieto Source Type: research
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics
Adv Drug Deliv Rev. 2024 Apr 3;208:115302. doi: 10.1016/j.addr.2024.115302. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a significant global health challenge. Consequently, the development of innovative therapeutic strategies to enhance CVDs treatment is imperative. RNA-based therapies, encompassing non-coding RNAs, mRNA, aptamers, and CRISPR/Cas9 technology, have emerged as promising tools for addressing CVDs. However, inherent challenges associated with RNA, such as poor cellular uptake, susceptibility to RNase degradation, and capture by the reticulo...
Source: Advanced Drug Delivery Reviews - April 4, 2024 Category: Drugs & Pharmacology Authors: Paula Gil-Cabrerizo Teresa Simon-Yarza Elisa Garbayo Mar ía J Blanco Prieto Source Type: research
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics
Adv Drug Deliv Rev. 2024 Apr 2:115302. doi: 10.1016/j.addr.2024.115302. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a significant global health challenge. Consequently, the development of innovative therapeutic strategies to enhance CVDs treatment is imperative. RNA-based therapies, encompassing non-coding RNAs, mRNA, aptamers, and CRISPR/Cas9 technology, have emerged as promising tools for addressing CVDs. However, inherent challenges associated with RNA, such as poor cellular uptake, susceptibility to RNase degradation, and capture by the reticuloendo...
Source: Advanced Drug Delivery Reviews - April 4, 2024 Category: Drugs & Pharmacology Authors: Paula Gil-Cabrerizo Teresa Simon-Yarza Elisa Garbayo Mar ía J Blanco Prieto Source Type: research
Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics
Adv Drug Deliv Rev. 2024 Apr 2:115302. doi: 10.1016/j.addr.2024.115302. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a significant global health challenge. Consequently, the development of innovative therapeutic strategies to enhance CVDs treatment is imperative. RNA-based therapies, encompassing non-coding RNAs, mRNA, aptamers, and CRISPR/Cas9 technology, have emerged as promising tools for addressing CVDs. However, inherent challenges associated with RNA, such as poor cellular uptake, susceptibility to RNase degradation, and capture by the reticuloendo...
Source: Advanced Drug Delivery Reviews - April 4, 2024 Category: Drugs & Pharmacology Authors: Paula Gil-Cabrerizo Teresa Simon-Yarza Elisa Garbayo Mar ía J Blanco Prieto Source Type: research
Towards more tolerable subcutaneous administration: Review of contributing factors for improving combination product design
Adv Drug Deliv Rev. 2024 Apr 1:115301. doi: 10.1016/j.addr.2024.115301. Online ahead of print.ABSTRACTSubcutaneous (SC) injections can be associated with local pain and discomfort that is subjective and may affect treatment adherence and overall patient experience. With innovations increasingly focused on finding ways to deliver higher doses and volumes (≥2 mL), there is a need to better understand the multiple intertwined factors that influence pain upon SC injection. As a priority for the SC Drug Development & Delivery Consortium, this manuscript provides a comprehensive review of known attributes from published li...
Source: Advanced Drug Delivery Reviews - April 3, 2024 Category: Drugs & Pharmacology Authors: Neil Mathias Sylvain Huille Marie Picci Robert P Mahoney Ronald J Pettis Brian Case Bernhard Helk David Kang Ronak Shah Junchi Ma Deep Bhattacharya Yogita Krishnamachari Dany Doucet Nathalie Maksimovikj Sahab Babaee Patrick Garidel Reza Esfandiary Rajesh Source Type: research
