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Cystic Lymphangioma-like Adenomatoid Tumor of the Adrenal Gland: Case Presentation and Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adenomatoid tumors (AT) are usually found in the genital tract of both sexes. They are very rarely located in extragenital sites, and are exceedingly rare in the adrenal. AT of the adrenal gland (AT-AG) are nonfunctioning, usually discovered incidentally and confused on imaging with other more common adrenal neoplasms. The overwhelming majority occur in males. Thirty-four cases have been reported so far, more often presenting grossly as solid tumors, rarely as solid with cystic areas, and 5 cases were almost entirely cystic. At histology they can be either circumscribed or locally infiltrative, and may pose diagnostic diff...
Source: Advances in Anatomic Pathology - November 1, 2009 Category: Pathology Tags: AMR Series Source Type: journals

Colorectal Cancer Due to Deficiency in DNA Mismatch Repair Function: A ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lynch syndrome (LS) is an autosomal dominant cancer predisposition syndrome attributable to deleterious germline mutations in mismatch repair (MMR) genes. The syndrome is typified by early-onset, frequently right-sided colorectal cancers (CRCs) with characteristic histologic features and tendency for multiplicity and an increased risk for extracolonic tumors at particular sites; it accounts for 1% to 5% of CRC. Deficient mismatch repair (dMMR) function manifests as immunohistochemically detectable absence of one or more MMR proteins and microsatellite instability (MSI). Approximately 15% of sporadic, noninherited CRC are c...
Source: Advances in Anatomic Pathology - October 30, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Plasmacytoid Dendritic Cells: Physiologic Roles and Pathologic StatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Plasmacytoid dendritic cells (PDCs) have perplexed pathologists for decades, undergoing multiple adjustments in nomenclature as their lineage and functions have been characterized. Although PDCs account for less than 0.1% of peripheral blood mononuclear cells, they serve as a principal source of interferon-[alpha] and are also known as interferon-I producing cells (IPCs). Upon activation in vitro, they can differentiate into dendritic cells, and recent studies have substantiated a potential role in antigen presentation. Thus, PDCs may act as a link between innate and adaptive immunity. Normally found in small quantities in...
Source: Advances in Anatomic Pathology - October 29, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Fluorescence In Situ Hybridization in the Diagnosis of Soft Tissue Neoplasms: A ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper presents an overview of the role of fluorescence in situ hybridization (FISH) in the diagnosis of soft tissue neoplasms. Many soft tissue neoplasms harbor characteristic translocations or amplification of gene regions, which can be assessed by FISH, and can be used to assist in their diagnosis. We discuss the major morphologic categories in which FISH has come to be used including high-grade round cell sarcomas, spindle cell sarcomas, low-grade myxoid neoplasms, adipocytic neoplasms, and malignant melanocytic neoplasms on the basis of a recent review of soft tissue neoplasms which were analyzed by FISH. We also ...
Source: Advances in Anatomic Pathology - October 29, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Core Components of a Comprehensive Quality Assurance Program in Anatomic PathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this article the core components of a comprehensive quality assurance and improvement plan are outlined. Quality anatomic pathology work comes with focus on accurate, timely, and complete reports. A commitment to continuous quality improvement and a systems approach with a persistent effort helps to achieve this end. Departments should have a quality assurance and improvement plan that includes a risk assessment of real and potential problems facing the laboratory. The plan should also list the individuals responsible for carrying out the program with adequate resources, a defined timetable, and annual assessment for pr...
Source: Advances in Anatomic Pathology - October 28, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Selective Pathologies of the Head and Neck in Children: A Developmental PerspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The range of pathology seen in the head and neck region is truly amazing and to a large extent probably mirrors the complex signaling pathways and careful orchestration of events that occurs between the primordial germ layers during the development of this region. As is true in general for the entire discipline of pediatric pathology, the head and neck pathology within this age group is as diverse and different as its adult counterpart. Cases that come across the pediatric head and neck surgical pathology bench are more heavily weighted toward developmental and congenital lesions such as branchial cleft anomalies, thyroglo...
Source: Advances in Anatomic Pathology - August 31, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Benign Cartilaginous Tumors of Bone: From Morphology to Somatic and Germ-line GeneticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Benign cartilaginous tumors of bones, intrinsic to their name, are tumors forming cartilaginous matrix with a clinically benign behavior. In this group, we recognize osteochondromas, (en)chondromas, chondroblastomas, and chondromyxoid fibromas. This group includes common tumors, that is, osteochondroma and (en)chondroma as well as rare tumors such as chondroblastoma and chondromyxoid fibroma. Several benign and malignant tumors may mimic benign cartilaginous tumors of bones. We reviewed the main morphologic features and the differential diagnosis is discussed. The genetics of these tumors is intriguing ranging from single ...
Source: Advances in Anatomic Pathology - August 31, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Olfactory Neuroblastoma: A Review and UpdateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Olfactory neuroblastoma (ONB) is a malignant neuroectodermal tumor that typically occurs in the superior nasal cavity. It is a distinct entity with features that include nesting, low-grade stippled nuclei, and neurofibrillary stroma with formation of pseudorosettes. It has a distinctive immunoprofile that includes keratin negativity, neuroendocrine marker positivity, and S100 positive sustentacular cells, which surround the nests of tumor in a supportive manner. Although the typical clinicopathologic features leave little room for misinterpretation, the wide variability in this tumor may cause diagnostic difficulty. This i...
Source: Advances in Anatomic Pathology - August 31, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Board Review Series: Pathology, 4th EdEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract available (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - August 31, 2009 Category: Pathology Tags: Book Review Source Type: journals

Poorly Differentiated Thyroid Carcinoma: A Cytologic-histologic ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The term poorly differentiated thyroid carcinoma (PDTC) was first proposed in the 1980s, but it was not definitively recognized as a distinct pathologic entity until the most recent classification of endocrine tumors by the World Health Organization in 2004. More recently, as a result of discussions in Turin, Italy, in 2006, diagnostic criteria were made more specific by a consensus of expert thyroid pathologists. The histologic and cytologic aspects are detailed with particular attention to key features helpful in the diagnosis of PDTC, both in surgical pathology and in cytology-based studies. Histologically, insular, sol...
Source: Advances in Anatomic Pathology - August 31, 2009 Category: Pathology Tags: Review Articles Source Type: journals

The Expression and Diagnostic Utility of p63 in the Female Genital TractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
p63 plays a key role in epithelial development in various organs, being expressed in myoepithelial cells and in basal cells of stratified epithelia. In the female genital tract, p63 is expressed in the basal and parabasal cells of mature cervical, vaginal and vulval squamous epithelium, and also in cervical reserve cells at the transformation zone and in immature metaplastic and atrophic cervical squamous epithelium. In this review, the diagnostic utility of p63 immunohistochemical staining in various pathologic scenarios within the female genital tract is discussed. Cervical microglandular hyperplasia is p63 positive with...
Source: Advances in Anatomic Pathology - August 29, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Ovarian Low-grade and High-grade Serous Carcinoma: Pathogenesis, Clinicopathologic and Molecular Biologic Features, and Diagnostic ProblemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian serous carcinomas have been graded using various systems. Recently, a 2-tier system in which tumors are subdivided into low grade and high grade has been proposed. This approach is simplistic, reproducible, and based on biologic evidence indicating that both tumors develop via different pathways. Low-grade serous carcinomas exhibit low-grade nuclei with infrequent mitotic figures. They evolve from adenofibromas or borderline tumors, have frequent mutations of the KRAS, BRAF, or ERBB2 genes, and lack TP53 mutations (Type I pathway). The progression to invasive carcinoma is a slow step-wise process. Low-grade tumors ...
Source: Advances in Anatomic Pathology - August 26, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Lymphocytic Disorders of the Gastrointestinal Tract: A Review for the Practicing PathologistEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Increased numbers of intraepithelial lymphocytes (lymphocytosis) can be found in the esophagus, stomach, small intestine, and colon in a variety of clinical circumstances. This review, directed at practicing pathologists, portrays the normal resident lymphocyte population in the mucosa of each segment of the digestive tract and discusses the different situations that may result in quantitative or qualitative alterations of intraepithelial lymphocytes. Esophageal lymphocytosis has not been fully characterized and its clinical significance, if any, awaits definition. Thus, this diagnosis is presently discouraged. In the stom...
Source: Advances in Anatomic Pathology - August 26, 2009 Category: Pathology Tags: Review Articles Source Type: journals

A New Collaborative Online Medical EncyclopediaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract available (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - June 30, 2009 Category: Pathology Tags: Pathology and the Internet Source Type: journals

Fatal Systemic Venous Air Embolism During Endoscopic Retrograde CholangiopancreatographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on an additional such fatal case, concerning a 78-year-old male patient, who several years previously had undergone surgical gastroduodenal resection with cholecystectomy and papillotomy, and was admitted for recurrent ascending cholangitis secondary to bile duct stones. During the third endoscopic cholangioscopic procedure for removal of bile duct stones, sudden cardiopulmonary arrest occurred. Death was due to massive pulmonary air embolism. Cerebral air embolism was also found. Autopsy was performed. A spontaneous duodenobiliary fistula was found. On the basis of bench radiologic investigation (retrograde supr...
Source: Advances in Anatomic Pathology - June 30, 2009 Category: Pathology Tags: AMR Series Source Type: journals

Diagnostic Problems in Breast PathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract available (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - June 30, 2009 Category: Pathology Tags: Book Reviews Source Type: journals

Goblet or Signet Ring Cells: That is the QuestionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Goblet cell carcinoid tumor is a rare mixed endocrine-exocrine neoplasm of the appendix. It carries an intermediate biologic behavior between a classic carcinoid tumor and a conventional adenocarcinoma. There has been a general lack of clinicopathologic parameters that can be reliably used to predict the clinical course and patient outcome. A recent retrospective study of a large number of appendiceal goblet cell carcinoids has shown that these tumors can be stratified into 3 subgroups based on careful histologic analysis: typical goblet cell carcinoid (group A); adenocarcinoma ex goblet cell carcinoid, signet ring cell ty...
Source: Advances in Anatomic Pathology - June 30, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Castleman Disease: An Update on Classification and the Spectrum of Associated LesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since its initial description, researchers have expanded the spectrum of Castleman disease to include not only the classic and well-recognized hyaline-vascular type, but also the plasma cell type and multicentric types of broader histologic range, including human herpes virus-8-associated Castleman disease. These less common subtypes of Castleman disease are less familiar, and may be under-recognized. Also of practical importance, current authors are restructuring the classification of multicentric Castleman disease to accommodate the emerging pathogenic role of human herpes virus-8 and its association with the recently de...
Source: Advances in Anatomic Pathology - June 30, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Multigene Classifiers, Prognostic Factors, and Predictors of Breast Cancer Clinical OutcomeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A series of multigene classifiers, prognostic and predictive tests have recently been introduced as potentially useful adjuncts for the management of recently diagnosed breast cancer patients. These tests have used both slide-based methods including immunohistochemistry and fluorescence in situ hybridization and nonmorphology driven molecular platforms including quantitative multiplex real time polymerase chain reaction and genomic microarray profiling. In this review, a series of partially and completely commercialized multigene assays are compared with the standard breast cancer clinico-pathologic variables and biomarker...
Source: Advances in Anatomic Pathology - June 30, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Diffuse Aggressive B-cell LymphomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diffuse aggressive B-cell lymphomas comprise a relatively common and increasingly diverse group of neoplasms. Newer modalities including gene expression profiling and an increasing panel of immunohistochemical markers have contributed to greater accuracy in defining these entities. Attention is paid not only to the neoplastic cells but also to the cellular and stromal milieu in which they proliferate. These distinctions may have therapeutic implications as well, with improved outcome related to newer and sometimes targeted therapies. At the same time there is increasing understanding of the overlap, which occurs in the gre...
Source: Advances in Anatomic Pathology - June 30, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Update on Percutaneous Needle Biopsy of Nonmalignant Breast LesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Certain nonmalignant lesions encountered on percutaneous breast biopsies pose dilemmas with regard to the most appropriate clinical management subsequent to needle biopsy (ie, surgical excision vs. follow-up). These lesions include columnar cell lesions, atypical ductal hyperplasia, lobular neoplasia, papillary lesions, radial scars, fibroepithelial lesions, and mucocele-like lesions. As minimally invasive diagnostic procedures are now standard it is more important than ever to be aware of the limitations of percutaneous biopsy, particularly with regard to apparently benign lesions because of the risk that the radiological...
Source: Advances in Anatomic Pathology - June 26, 2009 Category: Pathology Tags: Review Articles Source Type: journals

KRAS Mutation Testing in Colorectal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the US, colorectal cancer is the third leading cause of cancer-related death. Approximately 20% of patients present with metastatic disease, and an additional 30% to 40% develop metastasis during the course of their disease. Patients with metastatic colon cancer have a 5-year survival rate of only 11%. Although surgery is the mainstay of treatment for early stage colon cancer, adjuvant treatment is usually used in patients advanced stage disease. In particular, epidermal growth factor receptor (EGFR) inhibitor therapies have emerged as effective treatments in a subset of patients with metastatic colorectal carcinoma. Tw...
Source: Advances in Anatomic Pathology - June 25, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Ioachim's Lymph Node Pathology, 4th EdEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract available (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - May 1, 2009 Category: Pathology Tags: Book Review Source Type: journals

The Washington Manual of Surgical PathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract available (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - May 1, 2009 Category: Pathology Tags: Book Reviews Source Type: journals

Multiple Spontaneous Liver Cell Adenomas of Different Types (Liver Adenomatosis)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 1999, Nguyen et al divided focal nodular hyperplasia (FNH) in 2 groups, the classical and nonclassical. The former also included those cases of FNH with classical characteristics exhibited "on a subtle scale," whereas the latter included among others mainly the telangiectatic FNH (T-FNH) variant. Hepatocellular adenoma (HCA) was classically considered by definition a neoplasm with no ductal or ductular differentiation, but today the spectrum of HCA does include variant 3, which may have CK7+ ductules. Owing to genotypic-phenotypic correlation, T-FNH (synonymous with progressive FNH of others) is not considered yet as pa...
Source: Advances in Anatomic Pathology - May 1, 2009 Category: Pathology Tags: AMR Series Source Type: journals

Minimally Invasive Adenocarcinomas of the LungEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current World Health Organization (WHO) classification of lung adenocarcinomas includes noninvasive bronchioloalveolar carcinoma (BAC) and several patterns of invasive adenocarcinoma. The most common is a mixed subtype of adenocarcinoma. This group is very heterogenous and includes a wide spectrum of tumors ranging from adenocarcinomas with a dominant BAC growth pattern (lepidic growth) to frankly invasive adenocarcinoma with no BAC component. There is a tendency among clinicians to regard tumor as BAC if any significant amount of lepidic growth pattern within the tumor is identified. The change in WHO definition of BAC an...
Source: Advances in Anatomic Pathology - May 1, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Selected Topics in the Evaluation of Pediatric Gastrointestinal Mucosal BiopsiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The practice of pediatric gastrointestinal pathology provides specific challenges to the pathologist. Often the clinical information accompanying a biopsy specimen will read simply, "failure to thrive." Other situations, such as the evaluation of a neonate's rectal suction biopsy for Hirschsprung disease, are notorious for providing diagnostic challenges in high-pressure situations. In this review, we will discuss several commonly encountered situations in pediatric pathology: the evaluation of pediatric esophageal eosinophilia, a child who has swallowed a non food item, caustic substance, or hot liquid, the evaluation of ...
Source: Advances in Anatomic Pathology - May 1, 2009 Category: Pathology Tags: Review Articles Source Type: journals

The Discovery of Common Recurrent Transmembrane Protease Serine 2 (TMPRSS2)-Erythroblastosis Virus E26 Transforming Sequence (ETS) Gene Fusions in Prostate Cancer: Significance and Clinical ImplicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recurrent gene fusions and chromosomal rearrangements were previously thought to be the primary oncogenic mechanism of hematological malignancies and sarcomas. The recent discovery of recurrent gene fusions in a majority of prostate cancers represents a paradigm shift in understanding the molecular mechanisms of one of the most prevalent epithelial malignancies, with important clinical and biologic implications. The prostate cancer gene fusions that have been identified so far are characterized by 5'-genomic regulatory elements, most notably the androgen-controlled prostate specific gene, transmembrane protease serine 2, f...
Source: Advances in Anatomic Pathology - May 1, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Diagnosing Gastroesophageal Reflux Disease: The Pathologist's PerspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gastroesophageal reflux disease (GERD) is a common disease frequently encountered by surgical pathologists. Although the pathogenesis and clinical features of the disease have been studied for years, many unanswered questions remain. Typical clinical symptoms along with the endoscopic findings, pH monitoring, and biopsies, all support the diagnosis. However, these tests may yield conflicting findings, and at present there is no gold standard for the diagnosis of GERD. In patients with normal or nearly normal endoscopic findings (nonerosive reflux disease), the major diagnostic burden lies with the histology. The histologic...
Source: Advances in Anatomic Pathology - May 1, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Merkel Cell Carcinoma: ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Merkel cell carcinoma (MCC) is synonymous with primary cutaneous neuroendocrine carcinoma. It tends to affects elderly whites, but there is also an increased incidence among immunosuppressed patients. The recent identification of a novel polyomavirus associated with the tumor has stimulated renewed interest in its pathogenesis. MCC tends to show classic histologic features of a neuroendocrine carcinoma and is often positive for CK20, but nonclassic cytologic findings and unusual immunophenotypes may be observed and can lead to a diagnostic confusion. MCC needs to be distinguished from other primary cutaneous tumors with a ...
Source: Advances in Anatomic Pathology - May 1, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Calretinin: Diagnostic Utility in the Female Genital TractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The utility of calretinin was first described in the diagnosis of mesothelioma. In the female genital tract, calretinin was initially reported in Wolffian remnants and related lesions and later used in the diagnosis of sex cord stromal tumors of the ovary, endometrial stromal tumors with sex cord-like differentiation, and uterine tumors resembling sex cord tumors of the ovary. This review discusses calretinin expression in normal tissues of the female genital tract and highlights its potential utility in the diagnosis of these subsets of neoplasms with emphasis to tumors that may constitute a problem in their differential ...
Source: Advances in Anatomic Pathology - March 1, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Glypican-3: A Novel Diagnostic Marker for Hepatocellular Carcinoma and MoreEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the current information on the application of GPC3 immunostaining in surgical pathology and cytology. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - March 1, 2009 Category: Pathology Tags: New Antibody/Techniques Source Type: journals

Pathology and the Internet: Henry Stewart TalksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract available (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - March 1, 2009 Category: Pathology Tags: Pathology and the Internet Source Type: journals

Pathologic Features and Biologic Importance of Colorectal Serrated PolypsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Serrated polyps of the large intestine comprise a heterogeneous group of mucosal lesions that includes nondysplastic polyps, such as hyperplastic polyps and sessile serrated polyps, and polyps that show overt cytologic dysplasia, namely serrated adenomas and mixed hyperplastic/adenomatous polyps. These polyps have received increased recognition over the past 2 decades, as emerging evidence suggests that a subset may be precursors to colorectal carcinomas that lack chromosomal instability. Several investigators have proposed the concept of the "serrated neoplastic pathway" according to which nondysplastic serrated lesions d...
Source: Advances in Anatomic Pathology - March 1, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Utility of Diagnostic and Prognostic Markers in Urothelial Carcinoma of the BladderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Urothelial carcinoma (UCC) of the bladder demonstrates diverse morphologic features, often leading to diagnostic challenges in the discrimination between UCC and benign mimickers of neoplasia, and between primary UCC and secondary neoplasms involving the bladder. In situ lesions also provide diagnostic difficulty in some instances, most prominently in the distinction between normal, reactive urothelium and flat urothelial carcinoma in situ. The use of ancillary techniques, including panels of immunohistochemical markers, in distinguishing these entities has aided not only in the diagnosis of UCC, but has also provided insi...
Source: Advances in Anatomic Pathology - March 1, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Carcinomas of the Upper Aerodigestive Tract With Rearrangement of the Nuclear Protein of the Testis (NUT) Gene (NUT Midline Carcinomas)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This manuscript reviews carcinomas of the upper aerodigestive tract associated with genetic rearrangements of the nuclear protein of the testis (NUT) gene, also known as NUT midline carcinomas. The literature is reviewed regarding all reported cases of NUT midline carcinomas and the clinicopathologic features are discussed. Our current understanding of the molecular pathogenesis of the disease is also discussed, along with the differential diagnosis for undifferentiated or poorly differentiated malignancy of the upper aerodigestive tract. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - March 1, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Erratum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 134DOI: 10.1097/PAP.0b013e31819ec9fd (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - February 22, 2009 Category: Pathology Tags: HTML PDF (50 K) Source Type: journals

Mario A. Luna, MD 1935-2008.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 133DOI: 10.1097/PAP.0b013e318199799dAuthors: Batsakis, John G. MD *; Ayala, Alberto MD +; El Naggar, Adel K. MD, PhD * (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - February 22, 2009 Category: Pathology Tags: HTML PDF (84 K) Source Type: journals

Urologic Pathology 3rd Ed.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 132DOI: 10.1097/PAP.0b013e3181992440Authors: Renshaw, Andrew MD (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - February 22, 2009 Category: Pathology Tags: HTML PDF (198 K) Source Type: journals

Pathology and the Internet: Henry Stewart Talks.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 130DOI: 10.1097/PAP.0b013e3181992469Authors: Wheeler, Darren MD (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - February 22, 2009 Category: Pathology Tags: HTML PDF (199 K) Source Type: journals

Glypican-3: A Novel Diagnostic Marker for Hepatocellular Carcinoma and More.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 125DOI: 10.1097/PAP.0b013e3181992455Authors: Kandil, Dina H. MD; Cooper, Kumarasen MBChB, DPhil, FRCPath (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - February 22, 2009 Category: Pathology Tags: Abstract HTML PDF (293 K) Source Type: journals

Calretinin: Diagnostic Utility in the Female Genital Tract.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 118DOI: 10.1097/PAP.0b013e31819923ceAuthors: Portugal, Raquel MD; Oliva, Esther MD (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - February 22, 2009 Category: Pathology Tags: Abstract HTML PDF (409 K) Source Type: journals

Seeking Beyond Rejection: An Update on the Differential Diagnosis and a Practical Approach to Liver Allograft Biopsy Interpretation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 97DOI: 10.1097/PAP.0b013e31819946aaAuthors: Gao, Zu-hua MD, PhD, FRCPC (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - February 22, 2009 Category: Pathology Tags: Abstract HTML PDF (1.105 M) Source Type: journals

Carcinomas of the Upper Aerodigestive Tract With Rearrangement of the Nuclear Protein of the Testis (NUT) Gene (NUT Midline Carcinomas).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 92DOI: 10.1097/PAP.0b013e31819923e4Authors: Stelow, Edward B. MD *; French, Christopher A. MD + (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - February 22, 2009 Category: Pathology Tags: Abstract HTML PDF (434 K) Source Type: journals

Pathologic Features and Biologic Importance of Colorectal Serrated Polyps.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 79DOI: 10.1097/PAP.0b013e31819923b3Authors: Vakiani, Efsevia MD, PhD *; Yantiss, Rhonda K. MD + (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - February 22, 2009 Category: Pathology Tags: Abstract HTML PDF (1.471 M) Source Type: journals

Utility of Diagnostic and Prognostic Markers in Urothelial Carcinoma of the Bladder.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 67DOI: 10.1097/PAP.0b013e318199f89eAuthors: Coleman, Joshua F. MD; Hansel, Donna E. MD, PhD (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - February 22, 2009 Category: Pathology Tags: Abstract HTML PDF (821 K) Source Type: journals

Lupus Mastitis: A Clinicopathologic Review and Addition of a CaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lupus mastitis (LM) is a rare presentation of lupus erythematosus profundus or lupus panniculitis, an unusual and rare clinical variant of lupus erythematosus itself in which the inflammatory reaction occurs primarily in the deep subcutaneous adipose. Although not required for diagnosis, essentially all cases of LM present with systemic or discoid lupus. The etiology is uncertain. Histologically it is defined by a lymphocytic lobular panniculitis and a characteristic hyaline sclerosis of the adipose tissue. Treatment is primarily medical due to exacerbation of disease by surgical intervention. A high index of suspicion, an...
Source: Advances in Anatomic Pathology - January 1, 2009 Category: Pathology Tags: Review Articles Source Type: journals

The Expanding Family of Glioneuronal TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Three new entities have been recently added to the group of glioneuronal tumors in the most recent update of the World Health Organization classification of tumors of the central nervous system: papillary glioneuronal tumor, rosetted glioneuronal tumor with neuropil-like islands, and rosette-forming glioneuronal tumor of the fourth ventricle. These tumors are relatively infrequent lesions, and because of that, they can be challenging to diagnose for the practicing pathologist. In this article, we summarize the clinical and pathologic findings of these new lesions. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: Advan...
Source: Advances in Anatomic Pathology - January 1, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Molecular Alterations in Hereditary and Sporadic Thyroid and Parathyroid DiseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thyroid and parathyroid diseases are fairly common and can be either hereditary or sporadic in nature. Tumors and tumor-like processes account for the majority of surgical pathology specimens in both of these endocrine organs. Molecular alterations are well known to occur in both the hereditary and the sporadic settings, and include alterations in tumor suppressor genes and oncogenes. The genetic pathways of tumors of parathyroid and thyroid are beginning to be well understood and are proving to be useful diagnostic, prognostic, and potential therapeutic targets. The molecular alterations in parathyroid and thyroid tumors ...
Source: Advances in Anatomic Pathology - January 1, 2009 Category: Pathology Tags: Review Articles Source Type: journals

Epstein-Barr Virus in Lymphoproliferative Processes: An Update for the Diagnostic PathologistEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Epstein-Barr virus is an orally transmitted herpesvirus that is widespread in human populations and exhibits marked B-cell tropism. It is associated with more human neoplasms than any other known virus, and its role in the pathogenesis of such neoplasms has been the subject of intense investigation. This review presents an overview and update of the biology of Epstein-Barr virus and the diagnostic features of lymphoproliferative disorders associated with this intriguing human pathogen. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: Advances in Anatomic Pathology)
Source: Advances in Anatomic Pathology - January 1, 2009 Category: Pathology Tags: Review Articles Source Type: journals