Post-translational mechanisms in psychostimulant-induced neurotransmitter efflux
Adv Pharmacol. 2024;99:1-33. doi: 10.1016/bs.apha.2023.10.003. Epub 2024 Feb 17.ABSTRACTThe availability of monoamine neurotransmitters in the brain is under the control of dopamine, norepinephrine, and serotonin transporters expressed on the plasma membrane of monoaminergic neurons. By regulating transmitter levels these proteins mediate crucial functions including cognition, attention, and reward, and dysregulation of their activity is linked to mood and psychiatric disorders of these systems. Amphetamine-based transporter substrates stimulate non-exocytotic transmitter efflux that induces psychomotor stimulation, addict...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Roxanne A Vaughan L Keith Henry James D Foster Christopher R Brown Source Type: research
The role of sex and drug use during adolescence in determining the risk for adverse consequences of amphetamines
Adv Pharmacol. 2024;99:125-144. doi: 10.1016/bs.apha.2023.09.002. Epub 2023 Oct 20.ABSTRACTUse of amphetamines during adolescence, a critical period of brain development and reorganization, may lead to particularly adverse outcomes that are long-lasting. Similarly, female users may be uniquely vulnerable to certain aspects of drug use. A recognition of the role of use during adolescence and sex on outcomes of amphetamine and methamphetamine exposure are of critical importance in understanding and treating substance use disorders. This chapter highlights what human research, which has been largely epidemiological, suggests ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Lauren K Carrica Joshua M Gulley Source Type: research
Modeling methamphetamine use disorder in mammals: Sex differences in behavioral, biochemical, and transcriptional consequences
Adv Pharmacol. 2024;99:145-168. doi: 10.1016/bs.apha.2023.08.002. Epub 2024 Feb 9.ABSTRACTMethamphetamine (METH) is the most commonly misused amphetamine-type stimulant throughout the globe. METH is very rewarding, and its misuse can lead to a diagnosis of METH use disorder (MUD). Although METH use is observed in both sexes, there are, however, reported differences in the clinical manifestations of METH use and its consequences. These observations indicate the need for more research on the long-term sex-dependent consequences of METH taking in both preclinical and clinical settings. In effect, sex is a biological variable ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Atul P Daiwile Jean Lud Cadet Source Type: research
Epigenetic inheritance of phenotypes associated with parental exposure to cocaine
Adv Pharmacol. 2024;99:169-216. doi: 10.1016/bs.apha.2023.10.004. Epub 2023 Nov 7.ABSTRACTParental exposure to drugs of abuse induces changes in the germline that can be transmitted across subsequent generations, resulting in enduring effects on gene expression and behavior. This transgenerational inheritance involves a dynamic interplay of environmental, genetic, and epigenetic factors that impact an individual's vulnerability to neuropsychiatric disorders. This chapter aims to summarize recent research into the mechanisms underlying the inheritance of gene expression and phenotypic patterns associated with exposure to dr...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Matthew T Rich Sarah E Swinford-Jackson R Christopher Pierce Source Type: research
Immunity on ice: The impact of methamphetamine on peripheral immunity
Adv Pharmacol. 2024;99:217-250. doi: 10.1016/bs.apha.2023.09.003. Epub 2023 Oct 24.ABSTRACTMethamphetamine (METH) regulation of the dopamine transporter (DAT) and central nervous system (CNS) dopamine transmission have been extensively studied. However, our understanding of how METH influences neuroimmune communication and innate and adaptive immunity is still developing. Recent studies have shed light on the bidirectional communication between the CNS and the peripheral immune system. They have established a link between CNS dopamine levels, dopamine neuronal activity, and peripheral immunity. Akin to dopamine neurons in ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Emily J Miller Habibeh Khoshbouei Source Type: research
Stimulant prodrugs: A pharmacological and clinical assessment of their role in treating ADHD and binge-eating disorder
Adv Pharmacol. 2024;99:251-286. doi: 10.1016/bs.apha.2023.10.002. Epub 2023 Oct 25.ABSTRACTIn this review, we critically evaluate the contribution of prodrugs to treating two related psychiatric disorders, attention-deficit hyperactivity disorder (ADHD) and binge-eating disorder (BED). ADHD is characterized by inattentiveness, distractibility, impulsiveness, and hyperactivity. BED is also an impulse-control disorder which leads to frequent, compulsive episodes of excessive eating (binges). Lisdexamfetamine (LDX; prodrug of d-amphetamine) is approved to treat both ADHD and BED. Serdexmethylphenidate (SDX; prodrug of d-threo...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: David J Heal Jane Gosden Sharon L Smith Source Type: research
Modafinil, an atypical CNS stimulant?
Adv Pharmacol. 2024;99:287-326. doi: 10.1016/bs.apha.2023.10.006. Epub 2023 Nov 22.ABSTRACTModafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Melinda Hersey Gianluigi Tanda Source Type: research
The many enigmas of nicotine
Adv Pharmacol. 2024;99:327-354. doi: 10.1016/bs.apha.2023.08.001. Epub 2023 Oct 17.ABSTRACTThis review discusses the diverse effects of nicotine on the various nicotinic acetylcholine receptors of the central and peripheral nervous system and how those effects may promote the usage and addiction to tobacco products.PMID:38467485 | DOI:10.1016/bs.apha.2023.08.001 (Source: Advances in Pharmacology)
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Roger L Papke Source Type: research
Cholesterol modulation of interactions between psychostimulants and dopamine transporters
Adv Pharmacol. 2024;99:35-59. doi: 10.1016/bs.apha.2023.09.004. Epub 2023 Oct 24.ABSTRACTThe dopamine transporter (DAT) is a key site of action for cocaine and amphetamines. Dysfunctional DAT is associated with aberrant synaptic dopamine transmission and enhanced drug-seeking and taking behavior. Studies in cultured cells and ex vivo suggest that DAT function is sensitive to membrane cholesterol content. Although it is largely unknown whether psychostimulants alter cholesterol metabolism in the brain, emerging evidence indicates that peripheral cholesterol metabolism is altered in patients with psychostimulant use disorder...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Rong Chen Source Type: research
Modulators of nicotine reward and reinforcement
Adv Pharmacol. 2024;99:355-386. doi: 10.1016/bs.apha.2023.10.005. Epub 2024 Feb 10.ABSTRACTNicotine has been well-characterized for its ability to alter neurophysiology to promote rewarding and reinforcing properties. However, several exogenous chemicals possess properties that modulate or enhance nicotine's ability to alter neurophysiology. This chapter focuses on nicotine's impact on behavior through changes in neurophysiology and several chemical entities that in-turn modulate nicotine's ability to act as a neuromodulator.PMID:38467487 | DOI:10.1016/bs.apha.2023.10.005 (Source: Advances in Pharmacology)
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Brandon J Henderson Samuel Tetteh-Quarshie Nathan A Olszewski Source Type: research
Nicotine use disorder and Neuregulin 3: Opportunities for precision medicine
Adv Pharmacol. 2024;99:387-404. doi: 10.1016/bs.apha.2023.10.001. Epub 2024 Feb 9.ABSTRACTNicotine use disorder remains a major public health emergency despite years of trumpeting the consequences of smoking. This is likely due to the complex interplay of genetics and nicotine exposure across the lifespan of these individuals. Genetics influence all aspects of life, including complex disorders such as nicotine use disorder. This review first highlights the critical neurocircuitry underlying nicotine dependence and withdrawal, and then describes the cellular signaling mechanisms involved. Finally, current genetic, genomic, ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Taylor R Elder Jill R Turner Source Type: research
The pharmacology and neurotoxicology of synthetic cathinones
Adv Pharmacol. 2024;99:61-82. doi: 10.1016/bs.apha.2023.12.001. Epub 2023 Dec 26.ABSTRACTThe synthetic cathinones are man-made compounds derived from the naturally occurring drug cathinone, which is found in the khat plant. The drugs in this pharmacological class that will be the focus of this chapter include mephedrone, MDPV, methcathinone and methylone. These drugs are colloquially known as "bath salts". This misnomer suggests that these drugs are used for health improvement or that they have legitimate medical uses. The synthetic cathinones are dangerous drugs with powerful pharmacological effects that include high abus...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Mariana Angoa-Perez Donald M Kuhn Source Type: research
Structural and functional perspectives on interactions between synthetic cathinones and monoamine transporters
In conclusion, clarification of the structural aspects of compounds which modulate potency and selectivity at monoamine transporters is critical to identify and predict potential addictive drugs. This knowledge may allow prompt allocation of resources toward drugs that represent the greatest threats after drugs are identified by forensic laboratories.PMID:38467490 | DOI:10.1016/bs.apha.2023.09.001 (Source: Advances in Pharmacology)
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Vy T Nguyen Alan C Harris Jose M Eltit Source Type: research
Post-translational mechanisms in psychostimulant-induced neurotransmitter efflux
Adv Pharmacol. 2024;99:1-33. doi: 10.1016/bs.apha.2023.10.003. Epub 2024 Feb 17.ABSTRACTThe availability of monoamine neurotransmitters in the brain is under the control of dopamine, norepinephrine, and serotonin transporters expressed on the plasma membrane of monoaminergic neurons. By regulating transmitter levels these proteins mediate crucial functions including cognition, attention, and reward, and dysregulation of their activity is linked to mood and psychiatric disorders of these systems. Amphetamine-based transporter substrates stimulate non-exocytotic transmitter efflux that induces psychomotor stimulation, addict...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Roxanne A Vaughan L Keith Henry James D Foster Christopher R Brown Source Type: research
The role of sex and drug use during adolescence in determining the risk for adverse consequences of amphetamines
Adv Pharmacol. 2024;99:125-144. doi: 10.1016/bs.apha.2023.09.002. Epub 2023 Oct 20.ABSTRACTUse of amphetamines during adolescence, a critical period of brain development and reorganization, may lead to particularly adverse outcomes that are long-lasting. Similarly, female users may be uniquely vulnerable to certain aspects of drug use. A recognition of the role of use during adolescence and sex on outcomes of amphetamine and methamphetamine exposure are of critical importance in understanding and treating substance use disorders. This chapter highlights what human research, which has been largely epidemiological, suggests ...
Source: Advances in Pharmacology - March 11, 2024 Category: Drugs & Pharmacology Authors: Lauren K Carrica Joshua M Gulley Source Type: research
