Advances in Protein Chemistry and Structural Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Chapter Eleven Linear Analogues of the Lipopeptide Battacin With Potent In Vitro Activity Against S. aureus
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 112 Author(s): Hugh D. Glossop, Esperanza Pearl, Gayan H. De Zoysa, Vijayalekshmi Sarojini Eight linear analogues of the lipopeptide battacin were evaluated for their antibacterial activity against the Gram-positive Staphylococcus aureus. Of this library, the enantiomeric lipopeptide analogue 9.4 exhibited nanomolar inhibitory activity (MIC=200nmol) against S. aureus. Furthermore, this lipopeptide was resilient toward degradation conditions when exposed to rat serum proteases for up to 8h. (Source: Advances in Protein Che...
Source: Advances in Protein Chemistry and Structural Biology - May 16, 2018 Category: Biochemistry Source Type: research
Chapter Ten The Structure/Function Relationship in Antimicrobial Peptides: What Can we Obtain From Structural Data?
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 112 Author(s): Marlon H. Cardoso, Karen G.N. Oshiro, Samilla B. Rezende, Elizabete S. Cândido, Octávio L. Franco Antimicrobial peptides (AMPs) have been widely isolated from most organisms in nature. This class of antimicrobials may undergo changes in their sequence for improved physicochemical properties, including charge, hydrophobicity, and hydrophobic moment. It is known that such properties may be directly associated with AMPs’ structural arrangements and, consequently, could interfere in their modes of action ...
Source: Advances in Protein Chemistry and Structural Biology - May 16, 2018 Category: Biochemistry Source Type: research
Chapter Nine Peptide Derivatives of Erythropoietin in the Treatment of Neuroinflammation and Neurodegeneration
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 112 Author(s): Ilkcan Ercan, Kemal Ugur Tufekci, Ezgi Karaca, Sermin Genc, Kursad Genc During the past 35 years, recombinant DNA technology has allowed the production of a wide range of hematopoietic and neurotrophic growth factors including erythropoietin (EPO). These have emerged as promising protein drugs in various human diseases. Accumulated evidences have recently demonstrated the neuroprotective effect of EPO in preclinical models of acute and chronic degenerative disorders. Nevertheless, tissue protective effect...
Source: Advances in Protein Chemistry and Structural Biology - May 16, 2018 Category: Biochemistry Source Type: research
Chapter Eight Protein and Peptides for Elderly Health
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 112 Author(s): Nan Shang, Chalamaiah Meram, Nandika Bandara, Jianping Wu The world is aging rapidly; thus, the management of elderly health at an advanced age poses a new research challenge. The elderly is vulnerable to not only malnutrition but also hypofunction of all organs and a variety of chronic diseases such as sarcopenia, osteoporosis, gastrointestinal dysfunction, and mental problems. As the major macronutrient, food protein plays an important role in elderly health and well-being. In this chapter, the function o...
Source: Advances in Protein Chemistry and Structural Biology - May 16, 2018 Category: Biochemistry Source Type: research
Chapter Seven In Silico Tools and Databases for Designing Peptide-Based Vaccine and Drugs
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 112 Author(s): Salman Sadullah Usmani, Rajesh Kumar, Sherry Bhalla, Vinod Kumar, Gajendra P.S. Raghava The prolonged conventional approaches of drug screening and vaccine designing prerequisite patience, vigorous effort, outrageous cost as well as additional manpower. Screening and experimentally validating thousands of molecules for a specific therapeutic property never proved to be an easy task. Similarly, traditional way of vaccination includes administration of either whole or attenuated pathogen, which raises toxic...
Source: Advances in Protein Chemistry and Structural Biology - May 16, 2018 Category: Biochemistry Source Type: research
Chapter Six Smart Cell-Penetrating Peptide-Based Techniques for Intracellular Delivery of Therapeutic Macromolecules
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 112 Author(s): Yang He, Feng Li, Yongzhuo Huang Many therapeutic macromolecules must enter cells to take their action. However, their treatment outcomes are often hampered by their poor transportation into target cells. Therefore, efficient intracellular delivery of these macromolecules is critical for improving their therapeutic efficacy. Cell-penetrating peptide (CPP)-based approaches are one of the most efficient methods for intracellular delivery of macromolecular therapeutics. Nevertheless, poor specificity is a signif...
Source: Advances in Protein Chemistry and Structural Biology - May 16, 2018 Category: Biochemistry Source Type: research
Chapter Five Chimeric Small Antibody Fragments as Strategy to Deliver Therapeutic Payloads
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 112 Author(s): Sandra Aguiar, Joana Dias, Ana M. Manuel, Roberto Russo, Pedro M.P. Gois, Frederico A. da Silva, Joao Goncalves Antibody–drug conjugates (ADCs) represent an innovative class of biopharmaceuticals, which aim at achieving a site-specific delivery of cytotoxic agents to the target cell. The use of ADCs represents a promising strategy to overcome the disadvantages of conventional pharmacotherapy of cancer or neurological diseases, based on cytotoxic or immunomodulatory agents. ADCs consist of monoclonal...
Source: Advances in Protein Chemistry and Structural Biology - May 16, 2018 Category: Biochemistry Source Type: research
Chapter Four Transglutaminase and Sialyltransferase Enzymatic Approaches for Polymer Conjugation to Proteins
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 112 Author(s): Katia Maso, Antonella Grigoletto, Gianfranco Pasut Proteins hold a central role in medicine and biology, also confirmed by the several therapeutic applications based on biologic drugs. Such therapies are of great relevance thanks to high potency and safety of proteins. Nevertheless, many proteins as therapeutics might present issues like fast kidney clearance, rapid enzymatic degradation, or immunogenicity. Such defects implicate frequent administrations or administrations at high doses of the therapeutics, t...
Source: Advances in Protein Chemistry and Structural Biology - May 16, 2018 Category: Biochemistry Source Type: research
Chapter Three Dynamical Behavior of Somatostatin-14 and Its Cyclic Analogues as Analyzed in Bulk and on Plasmonic Silver Nanoparticles
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 112 Author(s): Belén Hernández, Yves-Marie Coïc, Eduardo López-Tobar, Santiago Sanchez-Cortes, Bruno Baron, Fernando Pflüger, Sergei G. Kruglik, Régis Cohen, Mahmoud Ghomi Primarily known as the inhibitor of growth hormone release, the role of somatostatin in many other inhibiting activities upon binding to its five G-protein-coupled receptors has been elucidated. Because of the short half-life of somatostatin, a number of synthetic analogues were elaborated for this peptide hormone. Herein, after recallin...
Source: Advances in Protein Chemistry and Structural Biology - May 16, 2018 Category: Biochemistry Source Type: research
Chapter Two Therapeutic Monoclonal Antibodies Delivery for the Glioblastoma Treatment
Publication date: 2018 Source:Advances in Protein Chemistry and Structural Biology, Volume 112 Author(s): Flávia Sousa, Rui P. Moura, Elias Moreira, Cláudia Martins, Bruno Sarmento Glioblastoma multiforme (GBM) is the most common and challenging primary malignant brain tumor, being the median overall survival between 10 and 14 months due to its invasive characteristics. GBM treatment is mainly based on the maximal surgical resection and radiotherapy associated to chemotherapy. Monoclonal antibodies (mAbs) have been used in chemotherapy protocols for GBM treatment in order to improve immunotherapy and antian...
Source: Advances in Protein Chemistry and Structural Biology - May 16, 2018 Category: Biochemistry Source Type: research
Chapter One Rational Design of Liquid Formulations of Proteins
The objective of this review is to lay out four concepts that will guide one to obtaining a stable liquid protein formulation. Additionally, the aim will be to identify factors that are intrinsic to the stabilization of any protein, not just a particular class of proteins, such as monoclonal antibodies (Uchiyama, 2014; Wang, Singh, Zeng, King, & Nema, 2007) and to provide guidelines aiming to effect stabilization. Noting that all approaches to stabilization face validation that must be performed empirically, it is hoped that the rational strategies described here will help the formulation scientist in their daily t...
Source: Advances in Protein Chemistry and Structural Biology - May 16, 2018 Category: Biochemistry Source Type: research
The OECD Principles for (Q)SAR Models in the Context of Knowledge Discovery in Databases (KDD)
Publication date: Available online 4 May 2018 Source:Advances in Protein Chemistry and Structural Biology Author(s): Gabriela Gomez-Jimenez, Karla Gonzalez-Ponce, Durbis J. Castillo-Pazos, Abraham Madariaga-Mazon, Joaquin Barroso-Flores, Fernando Cortes-Guzman, Karina Martinez-Mayorga The steps followed in the knowledge discovery in databases (KDD) process are well documented and are widely used in different areas where exploration of data is used for decision making. In turn, while different workflows for developing quantitative structure–activity relationship (QSAR) models have been proposed, includin...
Source: Advances in Protein Chemistry and Structural Biology - May 16, 2018 Category: Biochemistry Source Type: research
Chimeric Small Antibody Fragments as Strategy to Deliver Therapeutic Payloads
Publication date: Available online 6 April 2018 Source:Advances in Protein Chemistry and Structural Biology Author(s): Sandra Aguiar, Joana Dias, Ana M. Manuel, Roberto Russo, Pedro M.P. Gois, Frederico A. da Silva, Joao Goncalves Antibody–drug conjugates (ADCs) represent an innovative class of biopharmaceuticals, which aim at achieving a site-specific delivery of cytotoxic agents to the target cell. The use of ADCs represents a promising strategy to overcome the disadvantages of conventional pharmacotherapy of cancer or neurological diseases, based on cytotoxic or immunomodulatory agents. ADCs consist ...
Source: Advances in Protein Chemistry and Structural Biology - April 7, 2018 Category: Biochemistry Source Type: research
Linear Analogues of the Lipopeptide Battacin With Potent In Vitro Activity Against S. aureus
Publication date: Available online 6 April 2018 Source:Advances in Protein Chemistry and Structural Biology Author(s): Hugh D. Glossop, Esperanza Pearl, Gayan H. De Zoysa, Vijayalekshmi Sarojini Eight linear analogues of the lipopeptide battacin were evaluated for their antibacterial activity against the Gram-positive Staphylococcus aureus. Of this library, the enantiomeric lipopeptide analogue 9.4 exhibited nanomolar inhibitory activity (MIC=200nmol) against S. aureus. Furthermore, this lipopeptide was resilient toward degradation conditions when exposed to rat serum proteases for up to 8h. (Source: Advances i...
Source: Advances in Protein Chemistry and Structural Biology - April 7, 2018 Category: Biochemistry Source Type: research
Protein and Peptides for Elderly Health
Publication date: Available online 5 April 2018 Source:Advances in Protein Chemistry and Structural Biology Author(s): Nan Shang, Chalamaiah Meram, Nandika Bandara, Jianping Wu The world is aging rapidly; thus, the management of elderly health at an advanced age poses a new research challenge. The elderly is vulnerable to not only malnutrition but also hypofunction of all organs and a variety of chronic diseases such as sarcopenia, osteoporosis, gastrointestinal dysfunction, and mental problems. As the major macronutrient, food protein plays an important role in elderly health and well-being. In this chapter, t...
Source: Advances in Protein Chemistry and Structural Biology - April 5, 2018 Category: Biochemistry Source Type: research
