Ubiquitin E3 ligases assisted technologies in protein degradation: Sharing Pathways in Neurodegenerative Disorders and Cancer
Ageing Res Rev. 2024 Mar 21:102279. doi: 10.1016/j.arr.2024.102279. Online ahead of print.ABSTRACTE3 ligases, essential components of the ubiquitin-proteasome-mediated protein degradation system, play a critical role in cellular regulation. By covalently attaching ubiquitin (Ub) molecules to target proteins, these ligases mark them for degradation, influencing various bioprocesses. With over 600 E3 ligases identified, there is a growing realization of their potential as therapeutic candidates for addressing proteinopathies in cancer and neurodegenerative disorders (NDDs). Recent research has highlighted the need to delve d...
Source: Ageing Research Reviews - March 23, 2024 Category: Genetics & Stem Cells Authors: Aastha Kaushik Somya Parashar Rashmi K Ambasta Pravir Kumar Source Type: research

Ubiquitin E3 ligases assisted technologies in protein degradation: Sharing Pathways in Neurodegenerative Disorders and Cancer
Ageing Res Rev. 2024 Mar 21:102279. doi: 10.1016/j.arr.2024.102279. Online ahead of print.ABSTRACTE3 ligases, essential components of the ubiquitin-proteasome-mediated protein degradation system, play a critical role in cellular regulation. By covalently attaching ubiquitin (Ub) molecules to target proteins, these ligases mark them for degradation, influencing various bioprocesses. With over 600 E3 ligases identified, there is a growing realization of their potential as therapeutic candidates for addressing proteinopathies in cancer and neurodegenerative disorders (NDDs). Recent research has highlighted the need to delve d...
Source: Ageing Research Reviews - March 23, 2024 Category: Genetics & Stem Cells Authors: Aastha Kaushik Somya Parashar Rashmi K Ambasta Pravir Kumar Source Type: research

Ubiquitin E3 ligases assisted technologies in protein degradation: Sharing Pathways in Neurodegenerative Disorders and Cancer
Ageing Res Rev. 2024 Mar 21:102279. doi: 10.1016/j.arr.2024.102279. Online ahead of print.ABSTRACTE3 ligases, essential components of the ubiquitin-proteasome-mediated protein degradation system, play a critical role in cellular regulation. By covalently attaching ubiquitin (Ub) molecules to target proteins, these ligases mark them for degradation, influencing various bioprocesses. With over 600 E3 ligases identified, there is a growing realization of their potential as therapeutic candidates for addressing proteinopathies in cancer and neurodegenerative disorders (NDDs). Recent research has highlighted the need to delve d...
Source: Ageing Research Reviews - March 23, 2024 Category: Genetics & Stem Cells Authors: Aastha Kaushik Somya Parashar Rashmi K Ambasta Pravir Kumar Source Type: research

Optical coherence tomography as a potential surrogate marker of dopaminergic modulation across the life span
Ageing Res Rev. 2024 Mar 20:102280. doi: 10.1016/j.arr.2024.102280. Online ahead of print.ABSTRACTThe retina has been considered a "window to the brain" and shares similar innervation by the dopaminergic system with the cortex in terms of an unequal distribution of D1 and D2 receptors. Here, we provide a comprehensive overview that Optical Coherence Tomography (OCT), a non-invasive imaging technique, which provides an "in vivo" representation of the retina, shows promise to be used as a surrogate marker of dopaminergic neuromodulation in cognition. Overall, most evidence supports reduced retinal thickness in individuals wi...
Source: Ageing Research Reviews - March 22, 2024 Category: Genetics & Stem Cells Authors: Julia Elmers Lorenza S Colzato Focke Ziemssen Tjalf Ziemssen Christian Beste Source Type: research

Updates on brain regions and neuronal circuits of movement disorders in Parkinson's disease
Ageing Res Rev. 2023 Dec;92:102097. doi: 10.1016/j.arr.2023.102097. Epub 2023 Oct 28.ABSTRACTParkinson's disease (PD) is a progressive neurodegenerative disease with a global burden that affects more often in the elderly. The basal ganglia (BG) is believed to account for movement disorders in PD. More recently, new findings in the original regions in BG involved in motor control, as well as the new circuits or new nucleuses previously not specifically considered were explored. In the present review, we provide up-to-date information related to movement disorders and modulations in PD, especially from the perspectives of br...
Source: Ageing Research Reviews - March 21, 2024 Category: Genetics & Stem Cells Authors: Juan Wang Xiaoting Wang Hui Li Limin Shi Ning Song Junxia Xie Source Type: research

Alzheimer's Drugs APPlication for Down syndrome?
We present pertinent similarities between DS and AD in adult DS subjects, discuss challenges to target APP metabolites, and suggest that recently developed antibody treatments against Aβ may be worth investigating to treat AD in DS.PMID:38513771 | DOI:10.1016/j.arr.2024.102281 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - March 21, 2024 Category: Genetics & Stem Cells Authors: Debomoy K Lahiri Deborah K Sokol Source Type: research

Vascular Dementia: From Pathobiology to Emerging Perspectives
Ageing Res Rev. 2024 Mar 19:102278. doi: 10.1016/j.arr.2024.102278. Online ahead of print.ABSTRACTVascular dementia (VaD) is the second most common type of dementia. VaD is synonymous with ageing, and its symptoms place a significant burden on the health and wellbeing of older people. Despite the identification of a substantial number of risk factors for VaD, the pathological mechanisms underpinning this disease remain to be fully elucidated. Consequently, a biogerontological imperative exists to highlight the modifiable lifestyle factors which can mitigate against the risk of developing VaD. This review will critically ex...
Source: Ageing Research Reviews - March 21, 2024 Category: Genetics & Stem Cells Authors: Amy Elizabeth Morgan Mark Tom ás Mc Auley Source Type: research

Updates on brain regions and neuronal circuits of movement disorders in Parkinson's disease
Ageing Res Rev. 2023 Dec;92:102097. doi: 10.1016/j.arr.2023.102097. Epub 2023 Oct 28.ABSTRACTParkinson's disease (PD) is a progressive neurodegenerative disease with a global burden that affects more often in the elderly. The basal ganglia (BG) is believed to account for movement disorders in PD. More recently, new findings in the original regions in BG involved in motor control, as well as the new circuits or new nucleuses previously not specifically considered were explored. In the present review, we provide up-to-date information related to movement disorders and modulations in PD, especially from the perspectives of br...
Source: Ageing Research Reviews - March 21, 2024 Category: Genetics & Stem Cells Authors: Juan Wang Xiaoting Wang Hui Li Limin Shi Ning Song Junxia Xie Source Type: research

Alzheimer's Drugs APPlication for Down syndrome?
We present pertinent similarities between DS and AD in adult DS subjects, discuss challenges to target APP metabolites, and suggest that recently developed antibody treatments against Aβ may be worth investigating to treat AD in DS.PMID:38513771 | DOI:10.1016/j.arr.2024.102281 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - March 21, 2024 Category: Genetics & Stem Cells Authors: Debomoy K Lahiri Deborah K Sokol Source Type: research

Vascular Dementia: From Pathobiology to Emerging Perspectives
Ageing Res Rev. 2024 Mar 19:102278. doi: 10.1016/j.arr.2024.102278. Online ahead of print.ABSTRACTVascular dementia (VaD) is the second most common type of dementia. VaD is synonymous with ageing, and its symptoms place a significant burden on the health and wellbeing of older people. Despite the identification of a substantial number of risk factors for VaD, the pathological mechanisms underpinning this disease remain to be fully elucidated. Consequently, a biogerontological imperative exists to highlight the modifiable lifestyle factors which can mitigate against the risk of developing VaD. This review will critically ex...
Source: Ageing Research Reviews - March 21, 2024 Category: Genetics & Stem Cells Authors: Amy Elizabeth Morgan Mark Tom ás Mc Auley Source Type: research

Intermittent fasting and longevity: from animal models to implication for humans
Ageing Res Rev. 2024 Mar 16:102274. doi: 10.1016/j.arr.2024.102274. Online ahead of print.ABSTRACTIn recent years, intermittent fasting (IF) and its numerous modifications have been increasingly suggested as a promising therapy for age-related problems and a non-pharmacological strategy to extend lifespan. Despite the great variability in feeding schedules that we describe in the current work, underlying physiological processes are the same and include a periodic switch from glucose metabolism (generated by glycogenolysis) to fatty acids and fatty acid-derived ketones. Many of the beneficial effects of IF appear to be medi...
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Olha Strilbytska Svitlana Klishch Kenneth B Storey Alexander Koliada Oleh Lushchak Source Type: research

Worldwide cohort studies to support healthy ageing research: data availabilities and gaps
CONCLUSIONS: The comprehensive summary of data availability enables timely evidence to contribute to the United Nations Decades of Healthy Ageing goals of promoting healthy ageing for all. Highlighted gaps guide strategies for increased data collection in regions with limited cohort studies. Comprehensive data, encompassing intrinsic capacity and various sociodemographic, social, and environmental factors, is crucial for advancing our understanding of healthy ageing and its underlying pathways.PMID:38499160 | DOI:10.1016/j.arr.2024.102277 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Saman Khalatbari-Soltani Yafei Si Marielle Dominguez Tabitha Scott Fiona M Blyth Source Type: research

Amyloid-Induced Neurodegeneration: A Comprehensive Review through Aggregomics Perception of Proteins in Health and Pathology
Ageing Res Rev. 2024 Mar 16:102276. doi: 10.1016/j.arr.2024.102276. Online ahead of print.ABSTRACTAmyloidosis of protein caused by fibrillation and aggregation are some of the most exciting new edges not only in protein sciences but also in molecular medicines. The present review discusses recent advancements in the field of neurodegenerative diseases and therapeutic applications with ongoing clinical trials, featuring new areas of protein misfolding resulting in aggregation. The endogenous accretion of protein fibrils having fibrillar morphology symbolizes the beginning of neuro-disorders. Prognostic amyloidosis is promin...
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Sania Bashir Ayesha Aiman Mohammad Shahid Anis Ahmad Chaudhary Neha Sami Seemi Farhat Basir Imtaiyaz Hassan Asimul Islam Source Type: research

Intermittent fasting and longevity: from animal models to implication for humans
Ageing Res Rev. 2024 Mar 16:102274. doi: 10.1016/j.arr.2024.102274. Online ahead of print.ABSTRACTIn recent years, intermittent fasting (IF) and its numerous modifications have been increasingly suggested as a promising therapy for age-related problems and a non-pharmacological strategy to extend lifespan. Despite the great variability in feeding schedules that we describe in the current work, underlying physiological processes are the same and include a periodic switch from glucose metabolism (generated by glycogenolysis) to fatty acids and fatty acid-derived ketones. Many of the beneficial effects of IF appear to be medi...
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Olha Strilbytska Svitlana Klishch Kenneth B Storey Alexander Koliada Oleh Lushchak Source Type: research

Worldwide cohort studies to support healthy ageing research: data availabilities and gaps
CONCLUSIONS: The comprehensive summary of data availability enables timely evidence to contribute to the United Nations Decades of Healthy Ageing goals of promoting healthy ageing for all. Highlighted gaps guide strategies for increased data collection in regions with limited cohort studies. Comprehensive data, encompassing intrinsic capacity and various sociodemographic, social, and environmental factors, is crucial for advancing our understanding of healthy ageing and its underlying pathways.PMID:38499160 | DOI:10.1016/j.arr.2024.102277 (Source: Ageing Research Reviews)
Source: Ageing Research Reviews - March 18, 2024 Category: Genetics & Stem Cells Authors: Saman Khalatbari-Soltani Yafei Si Marielle Dominguez Tabitha Scott Fiona M Blyth Source Type: research