Characterization of age-associated gene expression changes in mouse sweat glands
Aging (Albany NY). 2024 Apr 17;16. doi: 10.18632/aging.205776. Online ahead of print.ABSTRACTEvaporation of sweat on the skin surface is the major mechanism for dissipating heat in humans. The secretory capacity of sweat glands (SWGs) declines during aging, leading to heat intolerance in the elderly, but the mechanisms responsible for this decline are poorly understood. We investigated the molecular changes accompanying SWG aging in mice, where sweat tests confirmed a significant reduction of active SWGs in old mice relative to young mice. We first identified SWG-enriched mRNAs by comparing the skin transcriptome of Eda mu...
Source: Aging - April 18, 2024 Category: Biomedical Science Authors: Alexandra G Zonnefeld Chang-Yi Cui Dimitrios Tsitsipatis Yulan Piao Jinshui Fan Krystyna Mazan-Mamczarz Yutong Xue Fred E Indig Supriyo De Myriam Gorospe Source Type: research
Identification of biomarkers and immune infiltration characterization of lipid metabolism associated genes in osteoarthritis based on machine learning algorithms
Aging (Albany NY). 2024 Apr 17;16. doi: 10.18632/aging.205740. Online ahead of print.ABSTRACTOsteoarthritis (OA) is a prevalent degenerative condition commonly observed in the elderly, leading to consequential disability. Despite notable advancements made in clinical strategies for OA, its pathogenesis remains uncertain. The intricate association between OA and metabolic processes has yet to receive comprehensive exploration. In our investigation, we leveraged public databases and applied machine learning algorithms, including WGCNA, LASSO, RF, immune infiltration analysis, and pathway enrichment analysis, to scrutinize th...
Source: Aging - April 18, 2024 Category: Biomedical Science Authors: Yuanye Ma Yang Liu Dan Luo Zhu Guo Hongfei Xiang Bohua Chen Xiaolin Wu Source Type: research
Comprehensive characterization of β-alanine metabolism-related genes in HCC identified a novel prognostic signature related to clinical outcomes
In conclusion, this study uncovers β-alanine's significant role in HCC for the first time, suggesting new research targets and directions for diagnosis and treatment.PMID:38637116 | DOI:10.18632/aging.205744 (Source: Aging)
Source: Aging - April 18, 2024 Category: Biomedical Science Authors: Yi Jia Xu Chen Hui Guo Biao Zhang Bin Liu Source Type: research
Whole-transcriptome profiling reveals potential biomarkers for the reversal of thymic epithelial cell senescence by umbilical cord mesenchymal stem cells
CONCLUSION: UCMSC coculture upregulated the expression of VEGFA, activated the PI3K-AKT signaling pathway, increased the expression of CDK2 and CCNE, decreased the expression of P27, and promoted the proliferation of TECs.PMID:38637117 | DOI:10.18632/aging.205738 (Source: Aging)
Source: Aging - April 18, 2024 Category: Biomedical Science Authors: Zai-Ling Yang Chuan Tian Jie He Hang Pan Guang-Ping Ruan Jing Zhao Kai Wang Xing-Hua Pan Xiang-Qing Zhu Source Type: research
Mining and exploration of rehabilitation nursing targets for colorectal cancer
CONCLUSIONS: High MYC and NCAPG2 expression has been observed in colorectal cancer, and increased MYC and NCAPG2 expression correlates with worse prognosis.PMID:38637125 | DOI:10.18632/aging.205739 (Source: Aging)
Source: Aging - April 18, 2024 Category: Biomedical Science Authors: Ruipu Li Jie He Zhijie Ni Jie Zhang Xiaoqian Chi Chunbo Kang Zhongbo Li Xubin Li Source Type: research
ITGAM is a critical gene in ischemic stroke
CONCLUSIONS: The inflammation and immune response were identified as potential pathological mechanisms of IS by bioinformatics and experiments. In addition, ITGAM may be considered a potential therapeutic target for IS.PMID:38637126 | DOI:10.18632/aging.205729 (Source: Aging)
Source: Aging - April 18, 2024 Category: Biomedical Science Authors: Lei Hou Zhongchen Li Xiaoli Guo Jiatao Lv Zonglei Chong Yilei Xiao Liyong Zhang Zefu Li Source Type: research
The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats
This study determined whether a continuous or intermittent KD (IKD) enhanced cognitive behavior in the TgF344-AD rat model of AD. At 6 months-old, TgF344-AD and wild-type (WT) littermates were placed on a control (CD), KD, or IKD (morning CD and afternoon KD) provided as two meals per day for 2 or 6 months. Cognitive and motor behavior and circulating β-hydroxybutyrate (BHB), AD biomarkers and blood lipids were assessed. Animals on a KD diet had elevated circulating BHB, with IKD levels intermediate to CD and KD. TgF344-AD rats displayed impaired spatial learning memory in the Barnes maze at 8 and 12 months of age and imp...
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Jennifer M Rutkowsky Zabrisky Roland Anthony Valenzuela An B Nguyen Heui Hye Park Natalie Six Ilknur Dursun Kyoungmi Kim Pamela J Lein Jon J Ramsey Source Type: research
The coupling between healthspan and lifespan in < em > Caenorhabditis < /em > depends on complex interactions between compound intervention and genetic background
In this study, thermotolerance, but not oxidative stress or swimming ability, correlates with lifespan. Notably, some compounds exert strong impact on some health measures without an equally strong impact on lifespan. Our results demonstrate the importance of assessing health and lifespan across genetic backgrounds in the effort to identify reproducible anti-aging interventions, with data underscoring how personalized treatments might be required to optimize health benefits.PMID:38613792 | DOI:10.18632/aging.205743 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Stephen A Banse E Grace Jackson Christine A Sedore Brian Onken David Hall Anna Coleman-Hulbert Phu Huynh Theo Garrett Erik Johnson Girish Harinath Delaney Inman Suzhen Guo Mackenzie Morshead Jian Xue Ron Falkowski Esteban Chen Christopher Herrera Allie J Source Type: research
NXPH4 can be used as a biomarker for pan-cancer and promotes colon cancer progression
Aging (Albany NY). 2024 Apr 12;16. doi: 10.18632/aging.205648. Online ahead of print.ABSTRACTNXPH4 promotes cancer proliferation and invasion. However, its specific role and mechanism in cancer remain unclear. Transcriptome and clinical data for pan-cancer were derived from the TCGA database. K-M survival curve and univariate Cox were used for prognostic analysis. CIBERSORT and TIMER algorithms were employed to calculate immune cell infiltration. Gene set enrichment analysis (GSEA) was employed for investigating the function of NXPH4. Western blot verified differential expression of NXPH4 in colon cancer. Functional assays...
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Zhipeng Zhang Pengfei Wang Siwen Chen Dezhi Xiang Jinzhen Chen Wanchang Huang Xiao Liu Tongwen Yi Dawei Wang Yunfei Pu Longfu He Hao Zhang Source Type: research
Machine learning for identifying tumor stemness genes and developing prognostic model in gastric cancer
Aging (Albany NY). 2024 Apr 12;16. doi: 10.18632/aging.205715. Online ahead of print.ABSTRACTGastric cancer presents a formidable challenge, marked by its debilitating nature and often dire prognosis. Emerging evidence underscores the pivotal role of tumor stem cells in exacerbating treatment resistance and fueling disease recurrence in gastric cancer. Thus, the identification of genes contributing to tumor stemness assumes paramount importance. Employing a comprehensive approach encompassing ssGSEA, WGCNA, and various machine learning algorithms, this study endeavors to delineate tumor stemness key genes (TSKGs). Subseque...
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Guo-Xing Li Yun-Peng Chen You-Yang Hu Wen-Jing Zhao Yun-Yan Lu Fu-Jian Wan Zhi-Jun Wu Xiang-Qian Wang Qi-Ying Yu Source Type: research
Garlic oil supplementation blocks inflammatory pyroptosis-related acute lung injury by suppressing the NF- κB/NLRP3 signaling pathway via H < sub > 2 < /sub > S generation
This study aimed to investigate the protective effects of garlic oil (GO) supplementation on lipopolysaccharide (LPS)-induced ALI models. Hematoxylin and eosin staining, pathology scores, lung myeloperoxidase (MPO) activity measurement, lung wet/dry (W/D) ratio detection, and bronchoalveolar lavage fluid (BALF) analysis were performed to investigate ALI histopathology. Real-time polymerase chain reaction, western blotting, and enzyme-linked immunosorbent assay were conducted to evaluate the expression levels of inflammatory factors, nuclear factor-κB (NF-κB), NLRP3, pyroptosis-related proteins, and H2S-producing enzymes....
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Tursunay Dilxat Qiang Shi Xiaofan Chen Xuxin Liu Source Type: research
Age and aging process alter the gut microbes
CONCLUSIONS: The individuals in different ages have characteristic gut microbes. The changes in community structure of gut microbes may be related to age-induced diseases.PMID:38613799 | DOI:10.18632/aging.205728 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Qu Zhanbo Zhuang Jing Han Shugao Wu Yinhang Chu Jian Yu Xiang Zhao Feimin Liu Jian Wu Xinyue Wu Wei Han Shuwen Source Type: research
PROS1 is a crucial gene in the macrophage efferocytosis of diabetic foot ulcers: a concerted analytical approach through the prisms of computer analysis
CONCLUSIONS: PROS1 was identified and validated as a biomarker for DFU. This finding has the potential to provide a target for macrophage clearance of DFU.PMID:38613800 | DOI:10.18632/aging.205732 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Hongshuo Shi Zhicheng Zhang Xin Yuan Guobin Liu Weijing Fan Wenbo Wang Source Type: research
Compound sophora decoction alleviates ulcerative colitis by regulating macrophage polarization through cGAS inhibition: network pharmacology and experimental validation
CONCLUSION: We concluded that CSD alleviated DSS-induced UC by inhibiting cGAS, thus regulating macrophage polarization.PMID:38613801 | DOI:10.18632/aging.205734 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Fei Gao Shuangjiao Deng Yujin Liu Pengcheng Wu Lifen Huang Feng Zhu Chunzhu Wei Yuyi Yuan Yang Gui Yushi Tian Heng Fan Hui Wu Source Type: research
Identification of a robust biomarker LAPTM4A for glioma based on comprehensive computational biology and experimental verification
CONCLUSIONS: In conclusion, our study identifies LATPM4A as a promising biomarker for prognosis and immune characteristics in glioma.PMID:38613802 | DOI:10.18632/aging.205736 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Yongqi Ding Yike Jiang Hong Zeng Minqin Zhou Xuanrui Zhou Zichuan Yu Jingying Pan Xitong Geng Yanting Zhu Hao Zheng Shuhan Huang Yiyang Gong Huabin Huang Chengfeng Xiong Da Huang Source Type: research
