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Life course vaccination and healthy aging.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors notice the low vaccine coverage rate among European citizens and inventory the multiple reasons leading to the non-use of preventable infectious diseases vaccines in adults whose mortality consequences represent an important and unexpected burden of diseases. These facts are in close relation with the disruption of vaccine recommendations after the childhood vaccine program, the poor literacy knowledge concerning vaccines among the general population, but also unfortunately among physicians and other health care workers. Popular beliefs, fear of side-effects, fear of needles facilitated the constitution of ...
Source: Aging Clinical and Experimental Research - June 1, 2009 Category: Geriatrics Authors: Gusmano MK, Michel JP Tags: Aging Clin Exp Res Source Type: journals

Coalition of advocates to vaccinate of Western European citizens aged 60 years and older.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The high burden of infectious diseases in adults aged 60 years and older is disproportionate, considering that many of these diseases are vaccine-preventable. Based on careful analysis of the reasons for vaccination barriers/failures in the European population, the two European geriatric and gerontological societies (the European Union Geriatric Medicine Society [EUGMS] and the International Association of Gerontology and Geriatrics - European Region [IAGG-ER]) propose careful adaptation of current vaccine guidelines to promote preventive aspects, concerning both life threatening-diseases (influenza, pneumococcal pneum...
Source: Aging Clinical and Experimental Research - June 1, 2009 Category: Geriatrics Authors: Michel JP, Chidiac C, Grubeck-Loebenstein B, Johnson RW, Lambert PH, Maggi S, Moulias R, Nicholson K, Werner H Tags: Aging Clin Exp Res Source Type: journals

Educational vaccine tools: the French initiative.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prevention is an important but neglected issue in geriatric medicine. Vaccination plays a major role in prevention of infectious diseases, but its implementation in clinical practice is far from perfect. To improve practice, a group of French experts composed of geriatricians and infectious disease specialists prepared a set of educational material about vaccination for older subjects. The tool has been designed to be used by medical teachers to help them teach this topic to other physicians, nursing staff and students. The group first defined teaching objectives and reviewed the scientific literature on the efficacy a...
Source: Aging Clinical and Experimental Research - June 1, 2009 Category: Geriatrics Authors: Belmin J, Bourée P, Camus D, Guiso N, Jeandel C, Trivalle C, Veyssier P Tags: Aging Clin Exp Res Source Type: journals

Willingness to vaccinate and to be vaccinated in adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vaccination may be mandated by regulation, as in some national infant vaccination programs, encouraged by health authorities, as in 'Flu vaccine campaigns for adults aged 60 years and older, or linked to the informed decision of individuals. Other methods include promotion by incentives to general practitioners, and recommendations from healthcare workers. All these factors contribute to variable vaccine coverage between countries and between different age and socio-economic groups. Many other factors, including providers' patientoriented interventions and reimbursement issues play an important role in determining the ...
Source: Aging Clinical and Experimental Research - June 1, 2009 Category: Geriatrics Authors: Baeyens JP, Lang PO, Michel JP Tags: Aging Clin Exp Res Source Type: journals

Herpes Zoster and Postherpetic Neuralgia: a review of the effects of vaccination.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Herpes zoster (HZ) results from reactivation of varicella zoster virus which has been persistent but clinically latent in dorsal root and cranial nerve ganglia since primary infection, usually as a child, with varicella (chicken pox). HZ affects 20-30% of individuals during their lifetime and up to 50% of those >/=80 years old. Although serious life- or sightthreatening complications occur rarely, postherpetic neuralgia (PHN) is the most common complication. Both HZ and PHN are most common in the elderly. Declining cell-mediated immunity resulting from immune senescence appears to be the cause. Incidence of HZ is al...
Source: Aging Clinical and Experimental Research - June 1, 2009 Category: Geriatrics Authors: Johnson RW Tags: Aging Clin Exp Res Source Type: journals

Tetanus and Pertussis vaccines: their usefulness in the aging population.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immunization is a safe, effective and simple way of preventing life-threatening tetanus infection in children and adults, and is therefore recommended for all age groups in all European countries. In older persons, despite waning immunity with increasing age, the majority of vaccinees attain protective tetanus immunity under a proper vaccination schedule. Based on the scientific evidence, decennial boosters are recommended for elderly persons who have received primary tetanus vaccination in the past. Until recently, pertussis vaccination was understood as an early childhood intervention. Due to decreasing immunity, re-...
Source: Aging Clinical and Experimental Research - June 1, 2009 Category: Geriatrics Authors: Topinková E, Maresová V Tags: Aging Clin Exp Res Source Type: journals

Pneumococcal vaccine in the elderly: a useful but forgotten vaccine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pneumococcal disease in the elderly is a major concern emphasizing the need for prevention. The review focuses on a literature-based analysis of the efficacy ("does the vaccine works?") and/or the effectiveness ("does vaccination help older population?") of pneumococcal vaccines 14- or 23-valent (PPV23) in the elderly. In the setting of Streptococcus pneumoniae pneumonia, there is still no conclusive evidence decisively confirming the efficacy of pneumococcal vaccine against pneumococcal pneumonia in the elderly populations. However, the efficacy of pneumococcal vaccination has been demonstrated in the prevention of in...
Source: Aging Clinical and Experimental Research - June 1, 2009 Category: Geriatrics Authors: Chidiac C, Ader F Tags: Aging Clin Exp Res Source Type: journals

Influenza vaccination for healthcare workers: from a simple concept to a resistant issue?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Different strategies for the management of influenza epidemics are particularly important in elderly population. High morbidity and mortality rates are associated with influenza in the elderly, and annual vaccination against flu is considered to be the best costeffective strategy. However, its efficiency is reduced in older adults and only half of them are protected. Several studies show that vaccinating healthcare workers is an efficient way of decreasing mortality rates in nursing home residents within influenza season. National and international public health authorities recommend therefore healthcare worker vaccina...
Source: Aging Clinical and Experimental Research - June 1, 2009 Category: Geriatrics Authors: Gavazzi G Tags: Aging Clin Exp Res Source Type: journals

Overview of vaccination policies for the elderly in Western European countries.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Age-related changes in the immune system are associated with increased susceptibility to infections, greater disease severity and poorer outcomes in the elderly compared with young adults. Both influenza and pneumonia are important causes of morbidity and mortality in the elderly, and herpes zoster also represents an important disease burden in this population. Vaccinations against influenza and Streptococcus pneumoniae (pneumococcus) have been shown to reduce the incidence of influenza and invasive pneumococcal disease, respectively, in the elderly. In addition, as is the case with diphtheria/tetanus and herpes zoster...
Source: Aging Clinical and Experimental Research - June 1, 2009 Category: Geriatrics Authors: Samson SI, Mégard Y Tags: Aging Clin Exp Res Source Type: journals

Immunosenescence and vaccine failure in the elderly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An age-related decline in immune responses in the elderly results in greater susceptibility to infection and reduced responses to vaccination. This decline in immune function affects both innate and adaptive immune systems. A meeting of experts in immunology and gerontology in Paris, France, in April 2008, considered current understanding of immunosenescence and its clinical consequences. Essential features of immunosenescence include: reduced natural killer cell cytotoxicity on a per cell basis; reduced number and function of dendritic cells in blood; decreased pools of naive T and B cells; and increases in the number...
Source: Aging Clinical and Experimental Research - June 1, 2009 Category: Geriatrics Authors: Grubeck-Loebenstein B, Della Bella S, Iorio AM, Michel JP, Pawelec G, Solana R Tags: Aging Clin Exp Res Source Type: journals

Vaccinations: "not just for kids".Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19571642 [PubMed - in process]
Source: Aging Clinical and Experimental Research - June 1, 2009 Category: Geriatrics Authors: Michel JP Tags: Aging Clin Exp Res Source Type: journals

Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: High circulating AGEs and RAGE predict cardiovascular disease mortality among older community-dwelling women. AGEs are a potential target for interventions, as serum AGEs can be lowered by change in dietary pattern and pharmacological treatment. PMID: 19448391 [PubMed - in process]
Source: Aging Clinical and Experimental Research - April 1, 2009 Category: Geriatrics Authors: Semba RD, Ferrucci L, Sun K, Beck J, Dalal M, Varadhan R, Walston J, Guralnik JM, Fried LP Tags: Aging Clin Exp Res Source Type: journals

Reduced midlife physical functioning among never married and childless men: evidence from the 1946 British birth cohort study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In this representative middle-aged population, unmarried and childless men faced greater risk of poor midlife physical function, even after adjustment for confounders. These findings suggest that for men, marriage and parenthood protect against functional decline in midlife. Alternatively, physical performance may be a marker of poorer health in earlier life, which affects the chance of marriage and parenthood. PMID: 19448390 [PubMed - in process]
Source: Aging Clinical and Experimental Research - April 1, 2009 Category: Geriatrics Authors: Guralnik JM, Butterworth S, Patel K, Mishra G, Kuh D Tags: Aging Clin Exp Res Source Type: journals

Preventive home visit model targeted to specific care needs of ambulatory frail elders: preliminary report of a randomized trial design.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The design's unique elements of regular evaluation of healthcare needs for targeted individuals within the long-term care insurance context will allow new understanding of the role and effectiveness of preventive home visits. PMID: 19448389 [PubMed - in process]
Source: Aging Clinical and Experimental Research - April 1, 2009 Category: Geriatrics Authors: Kono A, Fujita T, Tsumura C, Kondo T, Kushiyama K, Rubenstein LZ Tags: Aging Clin Exp Res Source Type: journals

Understanding information on clinical trials by persons with Alzheimer's dementia. A pilot study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Patients with Alzheimer's disease of mild to moderate severity show poor understanding of the design, risks and benefits of clinical trials. Enrolment of these patients in clinical trials must be accompanied by adequate measures for patient protection. PMID: 19448388 [PubMed - in process]
Source: Aging Clinical and Experimental Research - April 1, 2009 Category: Geriatrics Authors: Porteri C, Andreatta C, Anglani L, Pucci E, Frisoni GB Tags: Aging Clin Exp Res Source Type: journals

Social network assessment in community-dwelling older persons: results from a study of three European populations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Findings suggest that living alone status and a brief measure of social network identifies distinctive at-risk groups and potential pathways for intervention. Geriatric assessment programs including both social network measures may provide useful information about potentially modifiable social network risks in older persons. PMID: 19448387 [PubMed - in process]
Source: Aging Clinical and Experimental Research - April 1, 2009 Category: Geriatrics Authors: Blozik E, Wagner JT, Gillmann G, Iliffe S, von Renteln-Kruse W, Lubben J, Beck JC, Stuck AE, Clough-Gorr KM Tags: Aging Clin Exp Res Source Type: journals

Lack of compliance of staff in an intervention study with focus on nutrition, exercise and oral care among old (65+ yrs) Danish nursing home residents.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Lack of compliance by staff rather than residents seemed to be the main problem. In order to improve compliance in future studies, more focus should be put on the effect of practical implementation on staff. Insight into these matters may give valuable information to counteract staff problems, facilitate implementation in long term, and hence improve the benefits of nutrition interventions. PMID: 19448386 [PubMed - in process]
Source: Aging Clinical and Experimental Research - April 1, 2009 Category: Geriatrics Authors: Beck AM, Damkjaer K, Tetens I Tags: Aging Clin Exp Res Source Type: journals

Effects of vascular risk factors on balance assessed by computerized posturography in the elderly.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The cumulative presence of cardiovascular risk factors may contribute to impairment of balance in the elderly. This effect may be due to subclinical damage of that part of the nervous system controlling balance. PMID: 19448385 [PubMed - in process]
Source: Aging Clinical and Experimental Research - April 1, 2009 Category: Geriatrics Authors: Di Iorio A, Abate M, Pini B, Di Nicola I, Marinelli M, Guglielmi M, Battaglini C, Abate G Tags: Aging Clin Exp Res Source Type: journals

Predictors for institutionalization and prosthetic ambulation after major lower extremity amputation during an eight-year follow-up.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The majority of amputated patients cannot return home after their first LEA. Comorbid conditions particularly influencing functional capacity also hinder ambulation with a prosthesis. PMID: 19448384 [PubMed - in process]
Source: Aging Clinical and Experimental Research - April 1, 2009 Category: Geriatrics Authors: Remes L, Isoaho R, Vahlberg T, Viitanen M, Rautava P Tags: Aging Clin Exp Res Source Type: journals

Physical activity and performance in older persons with musculoskeletal impairment: results of a pilot study with 9-month follow-up.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In this physically impaired sample, a 3- month exercise program, compared with unsupervised regular walking, was associated with improved performance, fitness and vitality after discharge, and to delayed physical decline in the next 6-month follow-up. PMID: 19448383 [PubMed - in process]
Source: Aging Clinical and Experimental Research - April 1, 2009 Category: Geriatrics Authors: Cecchi F, Pasquini G, Chiti M, Molino Lova R, Enock E, Nofri G, Paperini A, Conti AA, Mannoni A, Macchi C Tags: Aging Clin Exp Res Source Type: journals

Vitamin E and aerobic exercise: effects on physical performance in older adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Six months of vitamin E supplementation has no additive effect beyond that of aerobic training on indices of physical performance and body composition in older sedentary adults. PMID: 19448382 [PubMed - in process]
Source: Aging Clinical and Experimental Research - April 1, 2009 Category: Geriatrics Authors: Nalbant O, Toktaş N, Toraman NF, Ogüş C, Aydin H, Kaçar C, Ozkaya YG Tags: Aging Clin Exp Res Source Type: journals

A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Ibuprofen, if used for relatively short periods of time and although well tolerated thanks to gastroprotection, does not seem to be effective in tertiary prevention of mild-moderate AD. Our results suggest the need to examine whether differences in the response to NSAIDs exist, based on ApoE epsilon4 carrier status. PMID: 19448381 [PubMed - in process]
Source: Aging Clinical and Experimental Research - April 1, 2009 Category: Geriatrics Authors: Pasqualetti P, Bonomini C, Dal Forno G, Paulon L, Sinforiani E, Marra C, Zanetti O, Rossini PM Tags: Aging Clin Exp Res Source Type: journals

A carbohydrate-rich drink shortly before surgery affected IGF-I bioavailability after a total hip replacement. A double-blind placebo controlled study on 29 patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: A carbohydrate- rich drink given shortly before surgery increases IGF-I bioavailability post-operatively in patients undergoing a THR, but has no significant effects on body composition after 2 months in physically active people. We suggest that, if the operation is postponed for more than four hours on the same day, an additional carbohydrate drink should be given. PMID: 19448380 [PubMed - in process]
Source: Aging Clinical and Experimental Research - April 1, 2009 Category: Geriatrics Authors: Aronsson A, Al-Ani NA, Brismar K, Hedström M Tags: Aging Clin Exp Res Source Type: journals

Hypopituitarism in the elderly: two case-reports with heterogeneous presentation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe here the cases of two elderly patients who were ultimately diagnosed as having HYPO, the clinical presentations and etiologies of which were different. In the first patient, an invasive non-secreting pituitary macroadenoma causing HYPO was detected on brain morphological evaluation for head trauma secondary to falling. Glucocorticoid replacement therapy was started. Thyroid function evaluation showed hyperthyroidism (due to a known toxic multinodular goiter), which was already on treatment with methimazole; ultimately, after withdrawal of the antithyroid drug, secondary hypothyroidism occurred. The patient unde...
Source: Aging Clinical and Experimental Research - February 1, 2009 Category: Geriatrics Authors: Foppiani L, Ruelle A, Quilici P, Del Monte P Tags: Aging Clin Exp Res Source Type: journals

Predictive validity of the Identification of Seniors At Risk (ISAR) screening tool in elderly patients presenting to two Italian Emergency Departments.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: ISAR can be used as a screening test to identify Italian elderly ED patients who have an increased 6-month risk of death, LTC placement, functional decline, ED revisit, or hospitalization. PMID: 19225272 [PubMed - in process]
Source: Aging Clinical and Experimental Research - February 1, 2009 Category: Geriatrics Authors: Salvi F, Morichi V, Grilli A, Spazzafumo L, Giorgi R, Polonara S, De Tommaso G, Dessì-Fulgheri P Tags: Aging Clin Exp Res Source Type: journals

Can tactile plantar stimulation improve postural control of persons with superficial plantar sensory deficit?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These results suggest that application of tactile plantar stimulation may compensate a loss of superficial plantar sensitivity. PMID: 19225271 [PubMed - in process]
Source: Aging Clinical and Experimental Research - February 1, 2009 Category: Geriatrics Authors: Bernard-Demanze L, Vuillerme N, Ferry M, Berger L Tags: Aging Clin Exp Res Source Type: journals

Relationship of a lifelong physical workload with physical function and low back pain in retired women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Lifelong heavy WRPL and high BMI seem to be risk factors for worse LBP and mobility in retired women. Mobility seems to be especially affected by these risk factors, and should be further investigated for prevention purposes. PMID: 19225270 [PubMed - in process]
Source: Aging Clinical and Experimental Research - February 1, 2009 Category: Geriatrics Authors: Gnudi S, Sitta E, Gnudi F, Pignotti E Tags: Aging Clin Exp Res Source Type: journals

Effects of computer training and internet usage on cognitive abilities in older adults: a randomized controlled study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Learning to use a computer and the internet does not benefit healthy, communitydwelling older adults with respect to many domains of cognitive functions. The implications of these findings for future studies that use cognitive challenge to counteract usual cognitive aging are discussed. PMID: 19225269 [PubMed - in process]
Source: Aging Clinical and Experimental Research - February 1, 2009 Category: Geriatrics Authors: Slegers K, van Boxtel M, Jolles J Tags: Aging Clin Exp Res Source Type: journals

Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The results of this study suggest that melatonin administration significantly improves sleep and behavioral disorders in the elderly and facilitates discontinuation of therapy with conventional hypnotic drugs. PMID: 19225268 [PubMed - in process]
Source: Aging Clinical and Experimental Research - February 1, 2009 Category: Geriatrics Authors: Garzón C, Guerrero JM, Aramburu O, Guzmán T Tags: Aging Clin Exp Res Source Type: journals

Prevalence and characteristics associated with self-reported gall bladder disease in Mexican American elders: results from the Hispanic Established Populations for Epidemiologic Studies in the Elderly (H-EPESE).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Age is not protective in the prevalence of GBD in elder Mexican Americans. Persistent underlying genetics and dietary habits most likely attribute to this consistent high percentage, even in the elderly. PMID: 19225267 [PubMed - in process]
Source: Aging Clinical and Experimental Research - February 1, 2009 Category: Geriatrics Authors: Escobar V, Oakes SL, Wood R, Becho J, Markides K, Espino DV Tags: Aging Clin Exp Res Source Type: journals

Bone mineral density and risk of fractures in aging, obese post-menopausal women with type 2 diabetes. The GIUMO Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In obese postmenopausal Caucasian women, type 2 DM produces an increase in BMD of the lumbar spine without changes in BMD of the proximal femur or in QUS measurements of the heel. The prevalence of vertebral, hip and non-vertebral fractures did not increase in type 2 DM. PMID: 19225266 [PubMed - in process]
Source: Aging Clinical and Experimental Research - February 1, 2009 Category: Geriatrics Authors: Sosa M, Saavedra P, Jódar E, Lozano-Tonkin C, Quesada JM, Torrijos A, Pérez-Cano R, Nogués X, Díaz-Curiel M, Moro MJ, Gómez C, Mosquera J, Alegre J, Olmos J, Muñoz-Torres M, Guañabens N, Del Pino J, Hawkins F, Tags: Aging Clin Exp Res Source Type: journals

Is the aging heart similar to the diabetic heart? Evaluation of LV function of the aging heart with Tissue Doppler Imaging.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The rise in IRT in the aging healthy heart is dependent on diastolic LV dysfunction consequent upon the formation of Advanced Glycosilation End-product (AGE) crosslinks with connectival proteins of interstitial myocardial tissue. Agerelated increase in oxidative stress also modifies some interstitial compounds, favoring hardening of ventricular walls. These changes are similar to those happening in the diabetic heart, and TDI seems to be able to define non-invasively which phase of the cardiac cycle is impaired. PMID: 19225265 [PubMed - in process]
Source: Aging Clinical and Experimental Research - February 1, 2009 Category: Geriatrics Authors: Cacciapuoti F, Marfella R, Paolisso G, Cacciapuoti F Tags: Aging Clin Exp Res Source Type: journals

Cardioprotective effect of EGb 761 on myocardial ultrastructure of young and old rat heart and antioxidant status during acute hypoxia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Better hypoxia tolerance is demonstrated by the young myocardium, and an obvious hypoxia-protective effect of EGb 761 in both age groups. PMID: 19225264 [PubMed - in process]
Source: Aging Clinical and Experimental Research - February 1, 2009 Category: Geriatrics Authors: Mozet C, Martin R, Welt K, Fitzl G Tags: Aging Clin Exp Res Source Type: journals

Proteolytic enzyme activity as a result of aging.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Analysis of combined proteolytic activity indicates that age-dependent patterning of blood serine protease enzyme activity may be related to age-related diseases. PMID: 19225263 [PubMed - in process]
Source: Aging Clinical and Experimental Research - February 1, 2009 Category: Geriatrics Authors: Paczek L, Michalska W, Bartlomiejczyk I Tags: Aging Clin Exp Res Source Type: journals

Partial androgen deficiency, depression and testosterone treatment in aging men.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides a critical review of the literature on depressive symptoms of partial androgen deficiency (PADAM) and their treatment with Testosterone (T). PADAM in aging males is responsible for a variety of behavioral symptoms, such as weakness, decreased libido and erectile dysfunction, lower psychological vitality, depressive mood, anxiety, insomnia, difficulty in concentrating, and memory impairment. The psychological and behavioural aspects of PADAM may overlap with signs and symptoms of major depression. Evidence of the relationship between androgen deficiency and male depression comes from studies that have as...
Source: Aging Clinical and Experimental Research - February 1, 2009 Category: Geriatrics Authors: Amore M, Scarlatti F, Quarta AL, Tagariello P Tags: Aging Clin Exp Res Source Type: journals

Hepatotoxicity after intravenous amiodarone.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe here the case of an elderly woman (77 years of age) who was hospitalized for acute atrial fibrillation, abdominal pain, and dyspnea. In the Emergency Department, treatment with intravenous amiodarone was begun. The following day, the patient developed acute liver damage; improved liver function occurred following the withdrawal of amiodarone. Complete recovery of liver function was documented after three weeks. Unfortunately, the patient died from a severe infectious disease, with multiple organ failure. PMID: 19179845 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Cataldi A, Gonella D, Robutti N, Siri M, Buonocore S, Odetti P Tags: Aging Clin Exp Res Source Type: journals

Depressive symptomatology and fracture risk in community-dwelling older men and women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In this large, community cohort, depressive symptomatology did not predict five-year risk of clinical fracture. Further research is needed to determine if individuals with major depressive disorder (MDD) are at higher fracture risk and whether neuroendocrine or hormonal dysregulation might contribute to such risk in MDD. PMID: 19179844 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Whitson HE, Sanders L, Pieper CF, Gold DT, Papaioannou A, Richards JB, Adachi JD, Lyles KW, Tags: Aging Clin Exp Res Source Type: journals

Attention and aging.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study demonstrates an agerelated reduction in attentive efficiency but, notably, this decline does not involve all components of attention. Subjects over 60 years of age show progressive slowing in processing of complex tasks and a reduced capacity to inhibit irrelevant stimuli. PMID: 19179843 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Commodari E, Guarnera M Tags: Aging Clin Exp Res Source Type: journals

Aging and prospective memory: the role of working memory and monitoring processes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These results suggest that even low-demanding prospective memory tasks are resource-consuming in old age, and that working memory efficiency, affected by the aging process, plays a crucial role in the successful accomplishment of PM actions. PMID: 19179842 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Bisiacchi PS, Tarantino V, Ciccola A Tags: Aging Clin Exp Res Source Type: journals

Association of cognitive impairment, activity limitation with latent traits in the GHQ-12 in the older elderly. The Bambui Health and Aging Study (BHAS).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The three-factor solution proposed by Graetz seems to be the best fit also for people over 75 years old. Further studies are needed to understand the conceptual and practical relevance of these underlying factors, particularly loss of confidence in the elderly population. PMID: 19179841 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Castro-Costa E, Uchoa E, Firmo JO, Lima-Costa MF, Prince M Tags: Aging Clin Exp Res Source Type: journals

The effects of interdisciplinary outpatient geriatrics on the use, costs and quality of health services in the fee-for-service environment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Interdisciplinary outpatient geriatric care in a FFS setting has the potential to avert hospital admissions for ambulatory care sensitive conditions and to reduce Medicare payments for hospital, skilled nursing facility, and home health care services. PMID: 19179840 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Famadas JC, Frick KD, Haydar ZR, Nicewander D, Ballard D, Boult C Tags: Aging Clin Exp Res Source Type: journals

Healthcare costs for people aged 65+ two years prior to their receiving long-term municipal care.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: A share of 13% had higher healthcare costs throughout the two years. Those involved were more often younger, men, married, and diagnosed with circulatory diseases, cancer, or injuries. Those older people at risk of high healthcare costs should benefit from systematic clinical assessments and more proactive and integrated care, to prevent escalating costs in the period preceding long-term municipal care and services. PMID: 19179839 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Kristensson J, Hallberg IR, Lundborg P Tags: Aging Clin Exp Res Source Type: journals

Peripheral arterial disease, diabetes and postural balance among elderly Finns: a population-based study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Individuals over 65 years of age with severe PAD showed increased balance impairment, a known risk factor for falls and disability in aged people. Diabetes affected balance somewhat less than PAD, but there was no formal evidence of the synergetic effect of the two diseases. Additional studies are indicated to reveal the possible effect of proper treatment of PAD and diabetes, combined with suitable training interventions on slowing down the progression of balance impairment. PMID: 19179838 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Suominen V, Salenius J, Sainio P, Reunanen A, Rantanen T Tags: Aging Clin Exp Res Source Type: journals

Admission profile is predictive of outcome in acute hospital care.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Evidence predictive of discharge and one-year outcomes in older acute hospital medical care patients seems to be visible from the beginning of the hospital stay. In order to increase the efficient use of health care services and quality of care, systematic standardized and streamlined assessment should be performed during the admission process. PMID: 19179837 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Jónsson PV, Noro A, Finne-Soveri H, Jensdóttir AB, Ljunggren G, Bucht G, Grue EV, Björnson J, Jonsén E, Schroll M Tags: Aging Clin Exp Res Source Type: journals

Common drug switching during long-term antiresorptive treatment: experience of four osteoporosis centers in Poland (2001-2005).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In almost 60% of the persistent patients, at least one switch of antiosteoporotic treatment occurred in the nearly 2- year observation period. The most frequent reasons for drug switching were adverse reactions, the high price of the drug, and ineffective treatment. PMID: 19179836 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Franek E, Tałałaj M, Wichrowska H, Czerwienska B, Filip R, Safranow K, Marcinowska-Suchowierska E, Wiecek A Tags: Aging Clin Exp Res Source Type: journals

The role of vitamin E in reversing bone loss.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Overall, the findings of the present study suggest that supplemental doses of vitamin E do not increase BMD values in male rat model of osteoporosis. However, human studies are needed to confirm the population findings indicating that individuals with higher vitamin E intake have higher bone mass. PMID: 19179835 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Chai SC, Wei CI, Brummel-Smith K, Arjmandi BH Tags: Aging Clin Exp Res Source Type: journals

Use of cereal fiber to facilitate adherence to a human caloric restriction program.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: A high fiber cereal intake may facilitate CR in humans self-selecting their own food; longer-term intervention studies are needed to confirm these findings. PMID: 19179834 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Gilhooly CH, Krupa Das S, Golden JK, McCrory MA, Rochon J, Delany JP, Freed AM, Fuss PJ, Dallal GE, Saltzman E, Roberts SB Tags: Aging Clin Exp Res Source Type: journals

Serum albumin level interferes with the effect of Donepezil in Alzheimer's disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our preliminary data suggest that serum albumin level should be monitored to evaluate the clinical efficacy of ChEIs therapy. PMID: 19179833 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Rozzini L, Vicini Chilovi B, Bertoletti E, Ghianda D, Conti M, Trabucchi M, Padovani A Tags: Aging Clin Exp Res Source Type: journals

Interaction of age and specific saliva component output on caries.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Changes in submandibular/ sublingual salivary component output during aging are correlated with high caries prevalence. These changes in saliva components over age may represent caries risk indicators. PMID: 19179832 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Mungia R, Cano SM, Johnson DA, Dang H, Brown JP Tags: Aging Clin Exp Res Source Type: journals

Reliability of equations to estimate glomerular filtration rate in the very old.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The clinical usefulness of formulas commonly used to estimate CrCl was limited, regardless of subjects' characteristics. PMID: 19179831 [PubMed - in process]
Source: Aging Clinical and Experimental Research - December 1, 2008 Category: Geriatrics Authors: Pedone C, Semeraro R, Chiurco D, D'Andria F, Gigante M, Coppola A, Corsonello A, Antonelli-Incalzi R Tags: Aging Clin Exp Res Source Type: journals