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Beta2-Receptor Polymorphisms in Patients Receiving Salmeterol with or without Fluticasone Propionate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The results showed no evidence of a pharmacogenetic effect of beta-receptor variation on salmeterol response. Clinical Trials Registry information available at www.clinicaltrials.gov, i.d. NCT00102882. PMID: 19910613 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 12, 2009 Category: Respiratory Medicine Authors: Bleecker ER, Nelson HS, Kraft M, Corren J, Meyers DA, Yancey SW, Anderson WH, Emmett AH, Ortega HG Tags: Am J Respir Crit Care Med Source Type: journals

CHEST: Lower Doses Benefit Pediatric Asthma PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In children who are hospitalized with asthma, a reduced-dose steroid regimen has no effect on hospital stays, and low-dose albuterol treatment is associated with a lower risk of metabolic acidosis than high-dose treatment, according to research presented at the 75th annual international scientific assembly of the American College of Chest Physicians, held from Oct. 31 to Nov. 5 in San Diego. (Source: Modern Medicine)
Source: Modern Medicine - November 4, 2009 Category: Journals (General) Source Type: info

Impact of a Household Environmental Intervention Delivered by Lay Health Workers on Asthma Symptom Control in Urban, Disadvantaged Children With Asthma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Lay health educators effectively reduced asthma triggers and increased caregiver asthma knowledge, which resulted in reduced emergency department visits, hospitalizations, and asthma symptoms. The relationships formed between the caregivers and the lay health educators appeared to positively impact asthma outcomes in this disadvantaged population. PMID: 19890172 [PubMed - as supplied by publisher] (Source: American Journal of Public Health)
Source: American Journal of Public Health - November 1, 2009 Category: Global & Universal Authors: Bryant-Stephens T, Kurian C, Guo R, Zhao H Tags: Am J Public Health Source Type: journals

Dysphagia associated with an elevated amylase levelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 34-year-old woman with a history of gastric ulcers, GERD, and asthma presented for endoscopic evaluation of recurrent dyspepsia and 2 months of dysphagia for solids. She denied odynophagia, weight loss, early satiety, and fever. Her medications included omeprazole and albuterol. Physical examination was unremarkable. Laboratory data were pertinent only for a mildly elevated serum amylase levels of 212 U/L and 180 U/L (normal range 30-110 U/L) with normal lipase levels on consecutive phlebotomies. An EGD revealed extrinsic compression of the distal esophagus (A) and a clean-based antral ulcer; testing for Helicobacter pyl...
Source: Gastrointestinal Endoscopy - October 31, 2009 Category: Gastroenterology Authors: Joseph M. McKinley, James S. Barthel, Tawfik N. Chami Tags: At the Focal Point Source Type: journals

COMBIVENT (Ipratropium Bromide And Albuterol Sulfate) Aerosol, Metered [Boehringer Ingelheim Pharmaceuticals, Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 23, 2009 Category: Drugs & Pharmacology Source Type: organizations

IPRATROPIUM BROMIDE AND ALBUTEROL SULFATEsolution [Mylan Pharmaceuticals Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 14, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 14, 2009 Category: Drugs & Pharmacology Source Type: organizations

Central and peripheral airway sites of nitric oxide gas exchange in copd.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In COPD, there was normal NO gas exchange in both large and small airways/alveoli and only large airway NO flux was suppressed with F250/S50 but not F100/S50 despite varying extent of emphysema. Peripheral NO must be corrected for axial NO backdiffusion to avoid spurious conclusions. NCT#00568347. PMID: 19820080 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - October 8, 2009 Category: Respiratory Medicine Authors: Gelb AF, Flynn Taylor C, Krishnan A, Fraser C, Shinar CM, Schein MJ, Osann K Tags: Chest Source Type: journals

Child asthma pumps questionedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is of value given the high prevalence of asthma and the universal use of bronchodilators in the management of asthma. These inhaled drugs are initially prescribed for use only when asthma becomes bad (i.e. as-required prescription rather than regular use), but if the condition is not controlled, secondly inhaled corticosteroids and thirdly, longer-acting bronchodilators may be prescribed. Given the widespread use of bronchodilators by both adults and children, reports on this study might potentially cause some alarm. While this concern is understandable, this is initial research and short-acting inhalers are ...
Source: NHS News Feed - October 7, 2009 Category: Consumer Health News Tags: Pregnancy/child Medication Heart/lungs Source Type: news

Influence of moisture accumulation in inline spacer on delivery of aerosol using metered-dose inhaler during mechanical ventilation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Aerosol delivery from a pMDI with spacer during mechanical ventilation was greater with a dry spacer and unchanged for the first hour after initiating heated humidification. Turning off the heated humidifier did not increase drug delivered. PMID: 19796413 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - September 30, 2009 Category: Respiratory Medicine Authors: Lin HL, Fink JB, Zhou Y, Cheng YS Tags: Respir Care Source Type: journals

Fibromuscular dysplasia of ostial left main coronary artery depicted by intravascular ultrasoundEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 32-year-old woman with no known cardiac risk factors was admitted at 12 weeks' gestation with exertional chest pain and shortness of breath. Four months prior, she noted severe exertional left-sided chest pressure. Her primary care physician had prescribed omeprazole and albuterol which did not improve her symptoms. One week prior, she developed left-sided chest pain radiating to the left arm which lasted for 20 min. An ECG obtained at the office visit that day was unremarkable. She was referred to our center for a stress echocardiogram. The treadmill stress test was stopped at 3 min after she developed chest pain. The E...
Source: Cardiovascular Revascularization Medicine - September 30, 2009 Category: Cardiology Authors: Amir H. Najafi, Zuyue Wang, Kenneth M. Kent Tags: Image of the Issue Source Type: journals

Attacking Asthma: Five steps to treat pediatric status asthmaticusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
EMS is called to the house of a 12-year-old male patient in severe respiratory distress. He has a history of asthma and is on multiple controller medicines, including Flovent, Singulair and albuterol sulfate. On arrival to the house, you find the patient seated in a tripod position. He's tachypneic and in severe distress. His mother states he developed cold symptoms yesterday and has used his albuterol inhaler multiple times today without improvement. (Source: JEMS: Journal of Emergency Medical Services)
Source: JEMS: Journal of Emergency Medical Services - September 30, 2009 Category: Emergency Medicine Authors: Mark Meredith, Jeremy Brywczynski, Corey Slovis Tags: Case of the Month Source Type: journals

Hydrofluoroalkane mandate in effect January 1, 2009: Switch from chlorofluorocarbon- to hydrofluoroalkane-propelled inhalers requires active transition.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The manufacture, sale, and distribution of chlorofluorocarbon-propelled albuterol metered-dose inhalers ceased as of December 31, 2008. Clinicians should actively transition patients to currently available hydrofluoroalkane-propelled devices, providing concise education and instruction for using the newer devices. PMID: 19781516 [PubMed - in process] (Source: Clinical Cornerstone)
Source: Clinical Cornerstone - September 30, 2009 Category: Primary Care Authors: Peters S Tags: Clin Cornerstone Source Type: journals

Proventil HFA (Albuterol Inhalation) - updated on RxListEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Proventil HFA (Albuterol Inhalation) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 30, 2009 Category: Drugs & Pharmacology Source Type: consumer

FDA Warns Consumers Not To Use Stolen Albuterol Sulfate Inhalation Solution And Ipratropium Bromide Inhalation SolutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The U.S. Food and Drug Administration advised consumers not to use certain respiratory medications purchased after Sept. 8, 2009 and manufactured by Dey L.P., a subsidiary of Mylan Inc., because the medications might have been part of a shipment being transported on a tractor-trailer stolen in Tampa, Fla., on Sept. 8, 2009. The respiratory medications, Ipratropium Bromide Inhalation Solution, 0. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 18, 2009 Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

FDA Says to Avoid Stolen Albuterol Sulfate, Ipratropium BromideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - September 17, 2009 Category: Primary Care Tags: Medical News Source Type: info

FDA Warns Consumers Not to Use Stolen Albuterol Sulfate Inhalation Solution and Ipratropium Bromide Inhalation SolutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The U.S. Food and Drug Administration today advised consumers not to use certain respiratory medications purchased after Sept. 8, 2009 and manufactured by Dey L.P., a subsidiary of Mylan Inc., because the medications might have been part of a shipment being transported on a tractor-trailer stolen in Tampa, Fla., on Sept. 8, 2009. (Source: Food and Drug Administration)
Source: Food and Drug Administration - September 17, 2009 Category: American Health Source Type: organizations

Albuterol Sulfate Inhalation Solution unit-dose vials (Dey LP brand)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two lots (35,760 cartons) stolen in Texas. Pharmacies encouraged to verify pedigree documentation for all purchases of Dey-labeled Albuterol. (Source: FDA MedWatch)
Source: FDA MedWatch - September 10, 2009 Category: American Health Source Type: organizations

Albuterol Sulfate Inhalation Solution unit-dose vials (Dey LP brand)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Audience: Pharmacists and pharmacy organizations [Posted 09/10/2009] FDA notified pharmacists that two complete Lots (9FE2 and 9G01) containing 35,760 cartons of Albuterol Sulfate Inhalation Solution, 0.083%, unit-dose vials was stolen in Texas... (Source: Drugs.com - FDA MedWatch Alerts)
Source: Drugs.com - FDA MedWatch Alerts - September 10, 2009 Category: Drugs & Pharmacology Source Type: news

Pharmacotherapy in pediatric critical illness: a prospective observational study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pharmacotherapy is an under-evaluated element of critical care medicine. In order to better understand pharmacotherapy in pediatric critical illness, we evaluated a cohort of emergency admissions to a university-affiliated pediatric intensive care unit (PICU). A prospective, observational study was performed. Eligible patients were admitted to this medical-surgical ICU for at least 24 hours. The primary outcomes were the number of drug orders written, the number of different medications ordered, and the number of drug administrations. Multiple regression analyses were used to identify factors independently associated w...
Source: Paediatric Drugs - September 4, 2009 Category: Pediatrics Authors: McDonnell C, Hum S, Frndova H, Parshuram CS Tags: Paediatr Drugs Source Type: journals

VENTOLIN (Albuterol Sulfate) Aerosol, Metered [SmithKline Beecham Corporation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 1, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 1, 2009 Category: Drugs & Pharmacology Source Type: organizations

Transition to Albuterol HFA: Are All Inhalers Interchangeable?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The prevalence of asthma in the United States is on the rise, and current asthma guidelines recommend prescribing short-acting beta agonists (albuterol) for treatment of reversible airway disease. Government regulations have imposed the transition from albuterol CFC (chlorofluorocarbon) to albuterol HFA (hydrofluroalkane). Prescribers must consider differences between CFC versus HFA inhalers, as well as variations among the available forms of albuterol HFA. Device design, increased cost for branded medication, patient preference, and a host of variables must be considered when deciding among the types of alb...
Source: The Journal for Nurse Practitioners - August 31, 2009 Category: Nursing Authors: Ashley Johnson, Bruce L. Wolf Tags: Features Source Type: journals

Measuring the Assessment and Counseling Provided with the Supply of Nonprescription Asthma Reliever Medication: A Simulated Patient Study (September).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Both patient assessment and medication counseling were suboptimal compared with recommended practice when nonprescription asthma reliever medication was supplied in the community pharmacy setting. Pharmacy and pharmacist demographic variables do not appear to affect assessment of asthma control. This research indicates the need for substantial improvements in practice in order to provide reliever medication in line with Quality Use of Medication principles of ensuring safe and effective use of medication. PMID: 19690228 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - August 17, 2009 Category: Drugs & Pharmacology Authors: Schneider CR, Everett AW, Geelhoed E, Kendall PA, Clifford RM Tags: Ann Pharmacother Source Type: journals

Warning on Stolen Albuterol Sulfate Inhalation Solution and Ipratropium Bromide Inhalation SolutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
FDA is advising consumers not to use certain respiratory medications purchased after Sept. 8, 2009 and manufactured by Dey L.P., a subsidiary of Mylan Inc., because the medications might have been part of a shipment being transported on a tractor-trailer stolen in Tampa, Fla., on Sept. 8, 2009. (Source: FDA Consumer Updates)
Source: FDA Consumer Updates - August 13, 2009 Category: Consumer Health Advice Source Type: organizations

Levalbuterol versus albuterolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Albuterol has been used for more than 40 years to treat acute asthma exacerbations as a racemic mixture of isomers: the active form, (R)-albuterol, or levalbuterol, and (S)-albuterol, classically considered inert. The single-isomer formulation, levalbuterol, has been synthesized recently and used therapeutically when the racemate is deemed less desirable. Basic investigations indicate that racemic albuterol and levalbuterol can produce effects that favor asthma remediation, including corticosteroid amplification and reduction of inflammatory mediators; in contrast, (S)-albuterol produces opposite ef...
Source: Current Allergy and Asthma Reports - August 11, 2009 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

Effects of airway obstruction on albuterol-mediated variations in the resistive and elastic properties of the respiratory system of patients with asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: In patients with asthma, increased airway obstruction results in greater reductions in R0 and Edyn after albuterol use. These reductions are greater among BR+ patients than among BR- patients. (Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - August 8, 2009 Category: Respiratory Medicine Source Type: journals

G.P.9.01 Albuterol promotes sustained improvement in motor function in spinal muscular atrophy type IIIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These 4 SMA-III patients had a variable but sustained response to oral albuterol treatment, most notably in improved ambulation. These observations may warrant a formal treatment trial. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - August 7, 2009 Category: Neurology Authors: R.S. Finkel, M.F. Benton, A.M. Glanzman Tags: 14th International Congress of the World Muscle Society Source Type: journals

VENTOLIN (Albuterol Sulfate) Aerosol, Metered [SmithKline Beecham Corporation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Aug 3, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - August 3, 2009 Category: Drugs & Pharmacology Source Type: organizations

Bronchodilator effects of exercise hyperpnea and albuterol in mild-to-moderate asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, in mild-to-moderate asthmatic individuals, hyperpnea at peak exercise was associated with a potent yet not complete bronchodilatation. During constant-load exercise, a transient bronchodilatation was followed by airway renarrowing, suggesting prevalence of constrictor over dilator effects of hyperpnea. Finally, the bronchodilator effect of hyperpnea was additive to that of albuterol. (Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - July 29, 2009 Category: Physiology Authors: Milanese, M., Saporiti, R., Bartolini, S., Pellegrino, R., Baroffio, M., Brusasco, V., Crimi, E. Tags: ARTICLES Source Type: journals

Medication Use Among ChildrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The majority of US children <12 years of age use ≥1 medication product in a given week. The preponderance of pediatric medication exposure involves over-the-counter products. (Source: PEDIATRICS)
Source: PEDIATRICS - July 26, 2009 Category: Pediatrics Authors: Vernacchio, L., Kelly, J. P., Kaufman, D. W., Mitchell, A. A. Tags: Therapeutics & Toxicology ARTICLES Source Type: journals

Evaluation of high-dose continuous nebulized levalbuterolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this issue of The Journal, Andrews et al from the University of Pennsylvania compared high-dose continuous levalbuterol to high-dose continuous racemic albuterol using equipotent doses in 81 children attending the emergency department with acute exacerbations of asthma. The adverse effects and the outcomes were similar in the two groups. Both groups were weaned from continuous bronchodilator therapy in 16-18 hours but no advantage was demonstrated for levalbuterol. It is notable that there was pharmaceutical company support for this study, although in the end the results did not benefit the company. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 22, 2009 Category: Pediatrics Authors: Robert W. Wilmott Source Type: journals

Asthma morbidity among inner-city adolescents receiving guidelines-based therapy: Role of predictors in the setting of high adherenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our findings demonstrate that the usual predictors of future disease activity have little predictive power when applied to a highly adherent population with persistent asthma that is receiving guidelines-based care. Thus, new predictors need to be identified that will be able to measure the continued fluctuation of disease that persists in highly adherent, well-treated populations such as the one studied. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - July 16, 2009 Category: Allergy & Immunology Authors: Rebecca S. Gruchalla, Hugh A. Sampson, Elizabeth Matsui, Gloria David, Peter J. Gergen, Agustin Calatroni, Mark Brown, Andrew H. Liu, Gordon R. Bloomberg, James F. Chmiel, Rajesh Kumar, Carin Lamm, Ernestine Smartt, Christine A. Sorkness, Suzanne F. Stein Tags: Asthma and lower airway disease Source Type: journals

The effects of racemic albuterol versus levalbuterol in very low birth weight infantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bronchodilators have been used in premature infants. Levalbuterol (LEV) an R-isomer of Albuterol has fewer hemodynamic side effects than Racemic Albuterol (RAC) in adults and children. In a retrospective study we sought to investigate the effects of LEV (0.31 mg) versus RAC (1.25 mg) in very low-birth weight infants (VLBW) who were treated with a beta-2 agonist for [ge]2 weeks. Medical records (between January 2001 and December 2006) were reviewed for patients' demographics, medications use, hemodynamic and respiratory parameters, hypokalemia and hyperglycemia. Among 811 VLBW infants who were admitted to our NICU, 16 infan...
Source: Pediatric Pulmonology - July 12, 2009 Category: Respiratory Medicine Authors: Maroun J. Mhanna, Jigisha S. Patel, Swati Patel, Robert Cohn Source Type: journals

IPRATROPIUM BROMIDE AND ALBUTEROL SULFATEsolution [Nephron Pharmaceuticals Corporation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Jul 8, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - July 8, 2009 Category: Drugs & Pharmacology Source Type: organizations

Dobutamine stress test and beta-agonist - a potential concern for nuclear cardiology testing: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Beta-agonists pre-treatment with dobutamine stress testing may induce coronary spasm in association with chest pain and ST elevation. Clinicians and nuclear cardiologist should be aware of this potential side effect of beta-agonists treatment with dobutamine stress testing, particularly since dobutamine stress testing in nuclear cardiology is done in patient with chronic obstructive lung disease. (Source: Cases Journal)
Source: Cases Journal - June 30, 2009 Category: Journals (General) Source Type: journals

Albuterol Found Ineffective in Acute Lung InjuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAN FRANCISCO — A placebo-controlled clinical trial of albuterol in acute lung injury was terminated after the first interim analysis showed that the beta-2 agonist was no better than placebo. (Source: Hospitalist News)
Source: Hospitalist News - June 30, 2009 Category: Hospital Management Authors: ROBERT FINN Tags: Pulmonary Medicine Source Type: journals

Montelukast induced acute hepatocellular liver injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Harugeri A, Parthasarathi G, Sharma J, D'Souza G A, Ramesh MJournal of Postgraduate Medicine 2009 55(2):141-142A 46-year-old male with uncontrolled asthma on inhaled albuterol and formoterol with budesonide was commenced on montelukast. He developed abdominal pain and jaundice 48 days after initiating montelukast therapy. His liver tests showed an increase in serum total bilirubin, conjugated bilirubin, aspartate aminotranferase, alanine aminotranferase, and alkaline phosphatase. The patient was evaluated for possible non-drug related liver injury. Montelukast was discontinued suspecting montelukast induced hepatoce...
Source: Journal of Postgraduate Medicine - June 25, 2009 Category: Internal Medicine Source Type: journals

Albuterol Often Used Incorrectly for Children's Asthma Flare-UpsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - June 18, 2009 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology Source Type: info

Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
African Americans are disproportionately affected by asthma. Social and economic factors play a role in this disparity, but there is evidence that genetic factors may also influence the development of asthma and response to therapy in African American children. Our hypothesis is that variations in asthma related genes contribute to the observed asthma disparities by influencing the response to asthma-specific therapy. In order to test this hypothesis, we characterized the clinical response to asthma-specific therapy in 107 African American children who presented to the emergency room in status asthmaticus, with a primary o...
Source: Pediatric Pulmonology - June 9, 2009 Category: Respiratory Medicine Authors: Paul E. Moore, Kelli K. Ryckman, Scott M. Williams, Neal Patel, Marshall L. Summar, James R. Sheller Source Type: journals

Home use of albuterol for asthma exacerbationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - June 7, 2009 Category: Allergy & Immunology Authors: Garbutt, Jane M.Freiner, DonnaHighstein, Gabrielle R.Nelson, Kyle A.Smith, Sharon R.Strunk, Robert C. Tags: ORIGINAL ARTICLES: INTERVENTIONS Source Type: journals

Effects of Formoterol on Contraction and Ca2+ Signaling of Mouse Airway Smooth Muscle Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Formoterol, a long-acting ss2-receptor agonist, is used to relieve bronchial constriction. However, formoterol is often a racemic formulation and contains both (R,R)- and (S,S)-enantiomers. Because the activity of each isomer is poorly defined, the mechanisms by which formoterol relaxes smooth muscle cells (SMC) of intrapulmonary airways are not well understood. Consequently, we compared the effects of (S,S)-, (R,R)- and racemic formoterol, as well as (R)-albuterol, on the contraction and Ca(2+) signaling of airway SMCs in mouse lung slices with phase-contrast and confocal microscopy. Small airways were contracted with...
Source: American Journal of Respiratory Cell and Molecular Biology - June 5, 2009 Category: Molecular Biology Authors: Delmotte P, Sanderson MJ Tags: Am J Respir Cell Mol Biol Source Type: journals

Indiana U. Research At The American College Of Sports Medicine ConferenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CAFFEINE SHOWN AS EFFECTIVE AT REDUCING EXERCISE-INDUCED ASTHMA SYMPTOMS AS AN ALBUTEROL INHALER An Indiana University study found that the ingestion of caffeine within an hour of exercise can reduce the symptoms of exercise induced asthma (EIA). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 1, 2009 Category: Consumer Health News Tags: Sports Medicine / Fitness Source Type: news

Pharmacogenomics of Acute Asthma: The β2-Adrenergic Receptor Gene as a Model for Future TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Asthma is a complex heterozygous multifactorial condition with variability in clinical features and response to treatment, likely related to interactions between genetics and environmental exposures. Pharmacogenomic research seeks to identify and elucidate relationships between genetic variation and therapeutic response. Multiple studies have examined genetic variation in the β2-adrenergic receptor gene and association with asthma phenotypes. Results suggest that single-nucleotide polymorphisms in this gene are associated with greater bronchodilation acutely after albuterol, worse pulmonary function over time with daily a...
Source: Clinical Pediatric Emergency Medicine - June 1, 2009 Category: Emergency Medicine Authors: Kyle A. Nelson Source Type: journals

Outbreak of Burkholderia cepacia bacteremia in immunocompetent children caused by contaminated nebulized sulbutamol in Saudi ArabiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: From early spring 2003 through May 2004, hospitals across Saudi Arabia and the Gulf Cooperation Council States experienced outbreaks of Burkholderia cepacia nosocomial infections secondary to the use of contaminated multidose albuterol nebulization solutions that were manufactured and distributed in the Gulf Region. After an exhaustive investigation, the National Guard's Department of Infection Prevention and Control identified the cause of the outbreak, and triggered a regional recall of the contaminated product in April 2004 after which there were no further cases. The National Guard Hospital outbreak inv...
Source: American Journal of Infection Control - June 1, 2009 Category: Infectious Diseases Authors: Ziad A. Memish, Gwen Stephens, Hanan H. Balkhy, Gwen Cunningham, Christine Francis, Greg Poff, On behalf of the Saudi National Guard Infection Prevention and Control Group Tags: Letters to the Editor Source Type: journals

Body mass index and phenotype in subjects with mild-to-moderate persistent asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Increased BMI is not associated with clinically significant worsening of impairment in subjects with mild-to-moderate persistent asthma. There is a modest association between increased BMI and reduced therapeutic effect of ICS-containing regimens in this patient population. Prospective studies evaluating the effect of being overweight or obese on treatment response in asthma are warranted. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - June 1, 2009 Category: Allergy & Immunology Authors: E. Rand Sutherland, Erik B. Lehman, Mihaela Teodorescu, Michael E. Wechsler, National Heart, Lung, and Blood Institute's Asthma Clinical Research Network Tags: Asthma and lower airway disease Source Type: journals

Augmentation of bronchodilator responsiveness by leukotriene modifiers in Puerto Rican and Mexican children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Among children with persistent asthma, use of leukotriene modifiers is associated with augmented bronchodilator responsiveness to albuterol in Puerto Ricans, but not Mexican Americans. This ethnic-specific, drug-drug interaction highlights the need for the further understanding of asthma pharmacogenetics among children from different ethnic groups to improve asthma outcomes. PMID: 19558011 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 31, 2009 Category: Allergy & Immunology Authors: Tcheurekdjian H, Thyne SM, Williams LK, Via M, Rodriguez-Santana JR, Rodriguez-Cintron W, Avila PC, Burchard EG Tags: Ann Allergy Asthma Immunol Source Type: journals

Home use of albuterol for asthma exacerbations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Caregivers reported that they would use albuterol to treat their child's worsening asthma symptoms, but many described inappropriate use. Detailed evaluation of proper albuterol use at home may provide insight into how health care professionals can better educate and support parents in their management of acute exacerbations and more effective use of AAPs. PMID: 19558010 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 31, 2009 Category: Allergy & Immunology Authors: Garbutt JM, Freiner D, Highstein GR, Nelson KA, Smith SR, Strunk RC Tags: Ann Allergy Asthma Immunol Source Type: journals

Combivent (Ipratropium Bromide and Albuterol Sulfate) - updated on RxListEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Combivent (Ipratropium Bromide and Albuterol Sulfate) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 26, 2009 Category: Drugs & Pharmacology Source Type: consumer

High-Dose Continuous Nebulized Levalbuterol for Pediatric Status Asthmaticus: A Randomized TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Substituting high-dose continuous LEV for RAC did not reduce the time on continuous therapy and had similar adverse effects in children who had failed initial treatment with RAC. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 21, 2009 Category: Pediatrics Authors: Timothy Andrews, Erin McGintee, Manoj K. Mittal, Lisa Tyler, Amber Chew, Xuemei Zhang, Nicholas Pawlowski, Joseph J. Zorc Tags: Original Articles Source Type: journals

Cellular coupling of potassium channels with β2 adrenoceptors in mediating myometrial relaxation in buffaloes (Bubalus bubalis)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Choudhury, S., Garg, S. K., Singh, T. U., Mishra, S. K. Cellular coupling of potassium channels with [beta]2 adrenoceptors in mediating myometrial relaxation in buffaloes (Bubalus bubalis). J. vet. Pharmacol. Therap. doi: 10.1111/j.1365-2885.2009.01084.x. Present study unravels the functional presence of potassium channels and their involvement in mediating [beta]2 adrenoceptors-induced myometrial relaxation in buffalo myometrium. Isolated myometrial preparations exhibited rhythmic spontaneity with regular pattern of amplitude and frequency. Levcromakalim produced concentration-dependent inhibitory effect on myometrial spo...
Source: Journal of Veterinary Pharmacology and Therapeutics - May 13, 2009 Category: Veterinary Research Authors: S. CHOUDHURY, S. K. GARG, T. U. SINGH, S. K. MISHRA Source Type: journals