Enhancement of peroxymonosulfate activation by humic acid-modified sludge biochar: Role of singlet oxygen and electron transfer pathway
Chemosphere. 2023 Apr 12:138690. doi: 10.1016/j.chemosphere.2023.138690. Online ahead of print.ABSTRACTSludge biochar (SBC) modified by humic acid (HA) was used to activate peroxymonosulfate (PMS) for degrading naproxen (NPX). HA-modified biochar (SBC-50HA) boosted the catalytic performance of SBC for PMS activation. The SBC-50HA/PMS system had good reusability and structural stability, and was unaffected by complex water bodies. The results of Fourier transform infrared (FTIR) and X-ray diffraction spectroscopy (XPS) indicated that graphitic carbon (CC), graphitic N, and C-O on SBC-50HA played a vital part on the removal ...
Source: Chemosphere - April 14, 2023 Category: Chemistry Authors: Shasha Li Meng Li Haozhan Zheng Xiaorong Xiong Huiyuan Deng Yintao Shi Dongsheng Xia Source Type: research
Enhancement of peroxymonosulfate activation by humic acid-modified sludge biochar: Role of singlet oxygen and electron transfer pathway
Chemosphere. 2023 Apr 13;329:138690. doi: 10.1016/j.chemosphere.2023.138690. Online ahead of print.ABSTRACTSludge biochar (SBC) modified by humic acid (HA) was used to activate peroxymonosulfate (PMS) for degrading naproxen (NPX). HA-modified biochar (SBC-50HA) boosted the catalytic performance of SBC for PMS activation. The SBC-50HA/PMS system had good reusability and structural stability, and was unaffected by complex water bodies. The results of Fourier transform infrared (FTIR) and X-ray diffraction spectroscopy (XPS) indicated that graphitic carbon (CC), graphitic N, and C-O on SBC-50HA played a vital part on the remo...
Source: Chemosphere - April 14, 2023 Category: Chemistry Authors: Shasha Li Meng Li Haozhan Zheng Xiaorong Xiong Huiyuan Deng Yintao Shi Dongsheng Xia Source Type: research
Enhancement of peroxymonosulfate activation by humic acid-modified sludge biochar: Role of singlet oxygen and electron transfer pathway
Chemosphere. 2023 Apr 13;329:138690. doi: 10.1016/j.chemosphere.2023.138690. Online ahead of print.ABSTRACTSludge biochar (SBC) modified by humic acid (HA) was used to activate peroxymonosulfate (PMS) for degrading naproxen (NPX). HA-modified biochar (SBC-50HA) boosted the catalytic performance of SBC for PMS activation. The SBC-50HA/PMS system had good reusability and structural stability, and was unaffected by complex water bodies. The results of Fourier transform infrared (FTIR) and X-ray diffraction spectroscopy (XPS) indicated that graphitic carbon (CC), graphitic N, and C-O on SBC-50HA played a vital part on the remo...
Source: Chemosphere - April 14, 2023 Category: Chemistry Authors: Shasha Li Meng Li Haozhan Zheng Xiaorong Xiong Huiyuan Deng Yintao Shi Dongsheng Xia Source Type: research
Molecules, Vol. 28, Pages 3421: Novel Vulgarin Derivatives: Chemical Transformation, In Silico and In Vitro Studies
Orabi
Vulgarin, an eudesmanolide sesquiterpene isolated from Artemisia judaica, was refluxed with iodine to produce two derivatives (1 and 2), which were purified and spectroscopically identified as naproxen methyl ester analogs. The reaction mechanism by which 1 and 2 were formed is explained using a sigmatropic reaction with a 1,3 shift. The scaffold hopping via lactone ring opening enabled the new derivatives of vulgarin (1 and 2) to fit well inside the COX-2 active site with ΔG of −7.73 and −7.58 kcal/mol, respectively, which was better than that of naproxen (&Delta...
Source: Molecules - April 13, 2023 Category: Chemistry Authors: Hanan G. Sary Mohammed A. Khedr Khaled Y. Orabi Tags: Article Source Type: research
Palladium-catalyzed remote < em > meta < /em > -C-H olefination of cinnamates
Chem Commun (Camb). 2023 Apr 12. doi: 10.1039/d3cc00289f. Online ahead of print.ABSTRACTThe palladium-catalyzed remote meta-C-H olefination of geometrically challenging substituted cinnamates using a nitrile directing group derived from 2-cyanobenzoic acid has been described. This new protocol is applicable to various olefin coupling partners and provides the corresponding meta-olefinated products in very good yields and with high selectivity. In addition, using this methodology, a variety of acrylates with tethered bioactive molecules, such as naphthoquinone, methyl salicylate, paracetamol, thymol, sesamol, chalcone, napr...
Source: Chemical Communications - April 12, 2023 Category: Chemistry Authors: Manickam Bakthadoss Mir Ashiq Hussain Tadiparthi Thirupathi Reddy Source Type: research
Palladium-catalyzed remote < em > meta < /em > -C-H olefination of cinnamates
Chem Commun (Camb). 2023 Apr 12. doi: 10.1039/d3cc00289f. Online ahead of print.ABSTRACTThe palladium-catalyzed remote meta-C-H olefination of geometrically challenging substituted cinnamates using a nitrile directing group derived from 2-cyanobenzoic acid has been described. This new protocol is applicable to various olefin coupling partners and provides the corresponding meta-olefinated products in very good yields and with high selectivity. In addition, using this methodology, a variety of acrylates with tethered bioactive molecules, such as naphthoquinone, methyl salicylate, paracetamol, thymol, sesamol, chalcone, napr...
Source: Chemical Communications - April 12, 2023 Category: Chemistry Authors: Manickam Bakthadoss Mir Ashiq Hussain Tadiparthi Thirupathi Reddy Source Type: research
Molecules, Vol. 28, Pages 3416: Identification of Novel Cyclooxygenase-1 Selective Inhibitors of Thiadiazole-Based Scaffold as Potent Anti-Inflammatory Agents with Safety Gastric and Cytotoxic Profile
hahzad Chohan
Ioannis Vizirianakis
Aliki Papadimitriou-Tsantarliotou
Athina Geronikaki
Major obstacles faced by the use of nonsteroidal anti-inflammatory drugs (NSAID) are their gastrointestinal toxicity induced by non-selective inhibition of both cyclooxygenases (COX) 1 and 2 and their cardiotoxicity associated with a certain class of COX-2 selective inhibitors. Recent studies have demonstrated that selective COX-1 and COX-2 inhibition generates compounds with no gastric damage. The aim of the current study is to develop novel anti-inflammatory agents with a better gastric profile. In our previous paper, we inve...
Source: Molecules - April 12, 2023 Category: Chemistry Authors: Michelyne Haroun Maria Fesatidou Anthi Petrou Christophe Tratrat Panagiotis Zagaliotis Antonis Gavalas Katharigatta N. Venugopala Hafedh Kochkar Promise M. Emeka Nancy S. Younis Dalia Ahmed Elmaghraby Mervt M. Almostafa Muhammad Shahzad Chohan Ioannis Viz Tags: Article Source Type: research
Molecules, Vol. 28, Pages 3395: Naproxen-Derived New Compound Inhibits the NF- & kappa;B, MAPK and PI3K/Akt Signaling Pathways Synergistically with Resveratrol in RAW264.7 Cells
Molecules, Vol. 28, Pages 3395: Naproxen-Derived New Compound Inhibits the NF-κB, MAPK and PI3K/Akt Signaling Pathways Synergistically with Resveratrol in RAW264.7 Cells
Molecules doi: 10.3390/molecules28083395
Authors:
Yi Ou
Zonglin You
Min Yao
Yingfan Cao
Xiu Xue
Min Chen
Rihui Wu
Lishe Gan
Dongli Li
Panpan Wu
Xuetao Xu
Wingleung Wong
Vincent Kam Wai Wong
Wenfeng Liu
Jiming Ye
Jingwei Jin
Naproxen is widely used for anti-inflammatory treatment but it can lead to serious side effects. To improve the anti-inflammatory activity and safety, a novel naproxen derivative containin...
Source: Molecules - April 12, 2023 Category: Chemistry Authors: Yi Ou Zonglin You Min Yao Yingfan Cao Xiu Xue Min Chen Rihui Wu Lishe Gan Dongli Li Panpan Wu Xuetao Xu Wingleung Wong Vincent Kam Wai Wong Wenfeng Liu Jiming Ye Jingwei Jin Tags: Article Source Type: research
Design, synthesis, biochemical and in silico characterization of novel naphthalene-thiourea conjugates as potential and selective inhibitors of alkaline phosphatase
AbstractNaphthalene ring is present in a number of FDA-approved, commercially available medications, including naphyrone, terbinafine, propranolol, naproxen, duloxetine, lasofoxetine, and bedaquiline. By reacting newly obtained 1-naphthoyl isothiocyanate with properly modified anilines, a library of ten novel naphthalene-thiourea conjugates (5a –5j) were produced with good to exceptional yields and high purity. The newly synthesized compounds were observed for their potential to inhibit alkaline phosphatase (ALP) and scavenge free radicals. All of the investigated compounds displayed a more powerful inhibitory profile th...
Source: Medicinal Chemistry Research - April 10, 2023 Category: Chemistry Source Type: research
Towards the Development of Dual Hypouricemic and Anti-inflammatory Candidates: Design, Synthesis, Stability Studies and Biological Evaluation of Some Mutual Ester Prodrugs of Febuxostat-NSAIDs
Bioorg Chem. 2023 Mar 31;135:106502. doi: 10.1016/j.bioorg.2023.106502. Online ahead of print.ABSTRACTTreatment of gout involves two basic approaches: reducing the serum uric acid mainly by xanthine oxidase inhibitors (XOIs) and alleviating the intensity of the accompanying acute arthritic inflammation using non-steroidal anti-inflammatory drugs (NSAIDs). Febuxostat (FEB) is the first non-purine XOI approved for the treatment of hyperuricemia and gout. The present study aims at combining the hypouricemic effect of FEB and the anti-inflammatory (AI) properties of NSAIDs in a single entity by adopting the "mutual prodrug" ap...
Source: Bioorganic Chemistry - April 8, 2023 Category: Chemistry Authors: Aya Y Rashad Hoda G Daabees Mohamed Elagawany Mohamed Shahin Ahmed E Abdel Moneim Sherif A F Rostom Source Type: research
Anti-Balamuthia mandrillaris and anti-Naegleria fowleri effects of drugs conjugated with various nanostructures
Arch Microbiol. 2023 Apr 5;205(5):170. doi: 10.1007/s00203-023-03518-8.ABSTRACTBalamuthia mandrillaris and Naegleria fowleri are protist pathogens that can cause fatal infections. Despite mortality rate of > 90%, there is no effective therapy. Treatment remains problematic involving repurposed drugs, e.g., azoles, amphotericin B and miltefosine but requires early diagnosis. In addition to drug discovery, modifying existing drugs using nanotechnology offers promise in the development of therapeutic interventions against these parasitic infections. Herein, various drugs conjugated with nanoparticles were developed and eva...
Source: Archives of Microbiology - April 5, 2023 Category: Microbiology Authors: Ruqaiyyah Siddiqui Anania Boghossian Saif S Alqassim Muhammad Kawish Jasra Gul Tooba Jabri Muhammad Raza Shah Naveed Ahmed Khan Source Type: research
Anti-Balamuthia mandrillaris and anti-Naegleria fowleri effects of drugs conjugated with various nanostructures
Arch Microbiol. 2023 Apr 5;205(5):170. doi: 10.1007/s00203-023-03518-8.ABSTRACTBalamuthia mandrillaris and Naegleria fowleri are protist pathogens that can cause fatal infections. Despite mortality rate of > 90%, there is no effective therapy. Treatment remains problematic involving repurposed drugs, e.g., azoles, amphotericin B and miltefosine but requires early diagnosis. In addition to drug discovery, modifying existing drugs using nanotechnology offers promise in the development of therapeutic interventions against these parasitic infections. Herein, various drugs conjugated with nanoparticles were developed and eva...
Source: Archives of Microbiology - April 5, 2023 Category: Microbiology Authors: Ruqaiyyah Siddiqui Anania Boghossian Saif S Alqassim Muhammad Kawish Jasra Gul Tooba Jabri Muhammad Raza Shah Naveed Ahmed Khan Source Type: research
Preparation and chromatographic performance of chiral peptide-based stationary phases for enantiomeric separation
This study presents the development of three new chiral stationary phases. They are based on silica modified with peptides containing phenylalanine and proline. Successful analyses and characterizations were conducted using Fourier transform infrared spectra, elemental analysis, and thermogravimetric analysis. After this, the enantioselective performance of the three chiral peptide-based columns was evaluated. The evaluation used 11 racemic compounds under normal-phase high performance liquid chromatography mode. Optimized enantiomeric separation conditions were established. Under these conditions, the enantiomers of flurb...
Source: Chirality - March 23, 2023 Category: Molecular Biology Authors: Zhengyue Ma Panpan Shang Delu Liu Yangyang Nie Yanli Liu Xinyuan Guo Benben Wei Ligai Bai Xiaoqiang Qiao Source Type: research
Dissemination of nonsteroidal anti-inflammatory drugs (NSAIDs) and metabolites from wastewater treatment plant to soils and agricultural crops via real-scale different agronomic practices
Environ Res. 2023 Mar 21:115731. doi: 10.1016/j.envres.2023.115731. Online ahead of print.ABSTRACTOne of the most consumed pharmaceutical subgroups across the world is nonsteroidal anti-inflammatory drugs (NSAIDs). However, the dissemination of these compounds to the natural environments through agronomic practices is a serious global problem. The hypothesis of this study is to reveal the transition of selected NSAIDs, paracetamol (PAR), diclofenac (DCF), ibuprofen (IBU), and naproxen (NAP) together with six main metabolites, detected in raw/treated wastewater (RWW/TWW) and sewage sludge generated in an urban wastewater tr...
Source: Environmental Research - March 23, 2023 Category: Environmental Health Authors: Taylan Dolu Bilgehan Nas Source Type: research
Preparation and chromatographic performance of chiral peptide-based stationary phases for enantiomeric separation
This study presents the development of three new chiral stationary phases. They are based on silica modified with peptides containing phenylalanine and proline. Successful analyses and characterizations were conducted using Fourier transform infrared spectra, elemental analysis, and thermogravimetric analysis. After this, the enantioselective performance of the three chiral peptide-based columns was evaluated. The evaluation used 11 racemic compounds under normal-phase high performance liquid chromatography mode. Optimized enantiomeric separation conditions were established. Under these conditions, the enantiomers of flurb...
Source: Chirality - March 23, 2023 Category: Molecular Biology Authors: Zhengyue Ma Panpan Shang Delu Liu Yangyang Nie Yanli Liu Xinyuan Guo Benben Wei Ligai Bai Xiaoqiang Qiao Source Type: research
