Ibuprofen modulates tetrodotoxin-resistant persistent Na < sup > + < /sup > currents at acidic pH in rat trigeminal ganglion neurons
Eur J Pharmacol. 2023 Nov 20:176218. doi: 10.1016/j.ejphar.2023.176218. Online ahead of print.ABSTRACTNon-steroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve various symptoms such as headache, arthralgia, and dental pain. While the primary mechanism of NSAID-based pain relief is the inhibition of cyclooxygenase-2, several NSAIDs also modulate other molecular targets related to nociceptive transmission such as voltage-gated Na+ channels. In the present study, we examined the effects of NSAIDs on persistent Na+ current (INaP) mediated by tetrodotoxin-resistant (TTX-R) Na+ channels in small-to medium-sized t...
Source: European Journal of Pharmacology - November 22, 2023 Category: Drugs & Pharmacology Authors: Jin-Hwa Cho Il-Sung Jang Source Type: research

Under what conditions is the intra-articular steroid injection superior to nonsteroidal anti-inflammatory drugs for treating sacroiliac joint pain?
CONCLUSIONS: In patients with sacroiliac joint pain, sacroiliac joint injection is superior to NSAIDs in pain relief in patients with pain for more than 30 days, those with MRI-diagnosed sacroiliitis, and those who have undergone lumbar surgery.PMID:37975377 | DOI:10.26355/eurrev_202311_34331 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2023 Category: Drugs & Pharmacology Authors: H S Cine E Uysal M Demirkol E Cetin Source Type: research

Under what conditions is the intra-articular steroid injection superior to nonsteroidal anti-inflammatory drugs for treating sacroiliac joint pain?
CONCLUSIONS: In patients with sacroiliac joint pain, sacroiliac joint injection is superior to NSAIDs in pain relief in patients with pain for more than 30 days, those with MRI-diagnosed sacroiliitis, and those who have undergone lumbar surgery.PMID:37975377 | DOI:10.26355/eurrev_202311_34331 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - November 17, 2023 Category: Drugs & Pharmacology Authors: H S Cine E Uysal M Demirkol E Cetin Source Type: research

Under what conditions is the intra-articular steroid injection superior to nonsteroidal anti-inflammatory drugs for treating sacroiliac joint pain?
CONCLUSIONS: In patients with sacroiliac joint pain, sacroiliac joint injection is superior to NSAIDs in pain relief in patients with pain for more than 30 days, those with MRI-diagnosed sacroiliitis, and those who have undergone lumbar surgery.PMID:37975377 | DOI:10.26355/eurrev_202311_34331 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - November 17, 2023 Category: Drugs & Pharmacology Authors: H S Cine E Uysal M Demirkol E Cetin Source Type: research

Under what conditions is the intra-articular steroid injection superior to nonsteroidal anti-inflammatory drugs for treating sacroiliac joint pain?
CONCLUSIONS: In patients with sacroiliac joint pain, sacroiliac joint injection is superior to NSAIDs in pain relief in patients with pain for more than 30 days, those with MRI-diagnosed sacroiliitis, and those who have undergone lumbar surgery.PMID:37975377 | DOI:10.26355/eurrev_202311_34331 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - November 17, 2023 Category: Drugs & Pharmacology Authors: H S Cine E Uysal M Demirkol E Cetin Source Type: research

Differential Effect of Non-Steroidal Anti-Inflammatory Drugs Aspirin and Naproxen against < em > TMPRSS2-ERG < /em > (Fusion)-Driven and Non-Fusion-Driven Prostate Cancer
Cancers (Basel). 2023 Oct 19;15(20):5054. doi: 10.3390/cancers15205054.ABSTRACTThe consumption of the non-steroidal anti-inflammatory drug (NSAID) aspirin is associated with a significant reduction in the risk of developing TMPRSS2-ERG (fusion)-positive prostate cancer (PCa) compared to fusion-negative PCa in population-based case-control studies; however, no extensive preclinical studies have been conducted to investigate and confirm these protective benefits. Thus, the focus of this study was to determine the potential usefulness of aspirin and another NSAID, naproxen, in PCa prevention, employing preclinical models of b...
Source: Cancer Control - October 28, 2023 Category: Cancer & Oncology Authors: Komal Raina Kushal Kandhari Rama Kant Ram Raj Prasad Neha Mishra Akhilendra K Maurya Jennifer T Fox Shizuko Sei Robert H Shoemaker Maarten C Bosland Paul Maroni Chapla Agarwal Rajesh Agarwal Source Type: research

Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research