Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research

Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research

Structured solubility behaviour in fed simulated intestinal fluids
This study has utilised nine bioequivalent simulated fed intestinal media recipes that cover over 90% of the compositional variability of sampled fed human intestinal fluid. The solubility of 24 drugs (Acidic; furosemide, ibuprofen, indomethacin, mefenamic acid, naproxen, phenytoin, piroxicam, valsartan, zafirlukast: Basic; aprepitant, atazanavir, bromocriptine, carvedilol, dipyridamole, posaconazole, tadalafil: Neutral; acyclovir, carbamazepine, felodipine, fenofibrate, griseofulvin, itraconazole, paracetamol, probucol) has been assessed to determine if structured solubility behaviour is present. The measured solubility b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 27, 2023 Category: Drugs & Pharmacology Authors: Maria In ês Silva Ibrahim Khadra Kate Pyper Gavin W Halbert Source Type: research

Refractory drug-induced systemic small-vessel vasculitis with two varied extracutaneous manifestations: a case report and review of the literature
ConclusionsThis case highlights the role of clopidogrel and ticagrelor as possible triggering agents for systemic small-vessel vasculitis and offers an insight into novel therapeutic strategies for refractory vasculitides. Further research is needed to build on the findings of a current report. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - October 27, 2023 Category: General Medicine Source Type: research

Cancers, Vol. 15, Pages 5054: Differential Effect of Non-Steroidal Anti-Inflammatory Drugs Aspirin and Naproxen against TMPRSS2-ERG (Fusion)-Driven and Non-Fusion-Driven Prostate Cancer
Agarwal Rajesh Agarwal The consumption of the non-steroidal anti-inflammatory drug (NSAID) aspirin is associated with a significant reduction in the risk of developing TMPRSS2-ERG (fusion)-positive prostate cancer (PCa) compared to fusion-negative PCa in population-based case–control studies; however, no extensive preclinical studies have been conducted to investigate and confirm these protective benefits. Thus, the focus of this study was to determine the potential usefulness of aspirin and another NSAID, naproxen, in PCa prevention, employing preclinical models of both TMPRSS2-ERG (fusion)-driven (wi...
Source: Cancers - October 19, 2023 Category: Cancer & Oncology Authors: Komal Raina Kushal Kandhari Rama Kant Ram Raj Prasad Neha Mishra Akhilendra K. Maurya Jennifer T. Fox Shizuko Sei Robert H. Shoemaker Maarten C. Bosland Paul Maroni Chapla Agarwal Rajesh Agarwal Tags: Article Source Type: research

Molecular docking and dynamics simulation of main protease of SARS-CoV-2 with naproxen derivative
Bioinformation. 2023 Apr 30;19(4):358-361. doi: 10.6026/97320630019358. eCollection 2023.ABSTRACTNaproxen is a well-known anti-inflammatory drug that is frequently used to relieve inflammation, stiffness, and swelling. Naproxen has previously demonstrated antiviral activity, particularly against the influenza-A virus. There have been previous studies regarding naproxen effect on SARS-CoV-2 infection. Therefore, it is of interest to document the molecular docking and dynamics simulation data of main protease of SARS-CoV-2 with naproxen derivative for further consideration.PMID:37822838 | PMC:PMC10563583 | DOI:10.6026/973206...
Source: Bioinformation - October 12, 2023 Category: Bioinformatics Authors: Rageh K Hussein Mohammad Marashdeh Ahmed M El-Khayatt Source Type: research

Molecular docking and dynamics simulation of main protease of SARS-CoV-2 with naproxen derivative
Bioinformation. 2023 Apr 30;19(4):358-361. doi: 10.6026/97320630019358. eCollection 2023.ABSTRACTNaproxen is a well-known anti-inflammatory drug that is frequently used to relieve inflammation, stiffness, and swelling. Naproxen has previously demonstrated antiviral activity, particularly against the influenza-A virus. There have been previous studies regarding naproxen effect on SARS-CoV-2 infection. Therefore, it is of interest to document the molecular docking and dynamics simulation data of main protease of SARS-CoV-2 with naproxen derivative for further consideration.PMID:37822838 | PMC:PMC10563583 | DOI:10.6026/973206...
Source: Bioinformation - October 12, 2023 Category: Bioinformatics Authors: Rageh K Hussein Mohammad Marashdeh Ahmed M El-Khayatt Source Type: research

N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial
CONCLUSIONS: This study suggested that NAC might be a relevant candidate for adjunct therapy in managing acute lumbar radiculopathy. Additional clinical trials are needed to validate these findings.TRIAL REGISTRATION: The trial was registered at Clinicaltrials.gov (identifier code: IRCT2012021 5009014N381). Registration date: 2021-02-06.PMID:37779397 | DOI:10.2174/0115748871250545230919055109 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - October 2, 2023 Category: Cancer & Oncology Authors: Bijan Heidari Zeinab-Alsadat Seyedian Maryam Mehrpooya Davoud Ahmadimoghaddam Mahtabalsadat Mirjalili Masood Ghiasian Source Type: research

Ecological risk assessment of pharmaceuticals and endocrine disrupting compounds in Brazilian surface waters
Environ Pollut. 2023 Sep 30:122628. doi: 10.1016/j.envpol.2023.122628. Online ahead of print.ABSTRACTPharmaceuticals and endocrine disrupting compounds are organic micropollutants that can cause adverse effects at low concentrations. Their occurrence in surface waters has been reported in several countries, including Brazil, at concentrations on the order of ngL-1, while the concentrations at which toxic effects are observed are often in the range of mg.L-1 to μg.L -1, however few studies have been undertaken to characterize risks they represent in Brazilian surface waters. Thus, the objective of this study was to evaluat...
Source: Environmental Pollution - October 2, 2023 Category: Environmental Health Authors: Amanda Teixeira de Rezende Ann H Mounteer Source Type: research

N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial
CONCLUSIONS: This study suggested that NAC might be a relevant candidate for adjunct therapy in managing acute lumbar radiculopathy. Additional clinical trials are needed to validate these findings.TRIAL REGISTRATION: The trial was registered at Clinicaltrials.gov (identifier code: IRCT2012021 5009014N381). Registration date: 2021-02-06.PMID:37779397 | DOI:10.2174/0115748871250545230919055109 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - October 2, 2023 Category: Cancer & Oncology Authors: Bijan Heidari Zeinab-Alsadat Seyedian Maryam Mehrpooya Davoud Ahmadimoghaddam Mahtabalsadat Mirjalili Masood Ghiasian Source Type: research

Ecological risk assessment of pharmaceuticals and endocrine disrupting compounds in Brazilian surface waters
Environ Pollut. 2023 Sep 30:122628. doi: 10.1016/j.envpol.2023.122628. Online ahead of print.ABSTRACTPharmaceuticals and endocrine disrupting compounds are organic micropollutants that can cause adverse effects at low concentrations. Their occurrence in surface waters has been reported in several countries, including Brazil, at concentrations on the order of ngL-1, while the concentrations at which toxic effects are observed are often in the range of mg.L-1 to μg.L -1, however few studies have been undertaken to characterize risks they represent in Brazilian surface waters. Thus, the objective of this study was to evaluat...
Source: Environmental Pollution - October 2, 2023 Category: Environmental Health Authors: Amanda Teixeira de Rezende Ann H Mounteer Source Type: research

N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial
CONCLUSIONS: This study suggested that NAC might be a relevant candidate for adjunct therapy in managing acute lumbar radiculopathy. Additional clinical trials are needed to validate these findings.TRIAL REGISTRATION: The trial was registered at Clinicaltrials.gov (identifier code: IRCT2012021 5009014N381). Registration date: 2021-02-06.PMID:37779397 | DOI:10.2174/0115748871250545230919055109 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - October 2, 2023 Category: Cancer & Oncology Authors: Bijan Heidari Zeinab-Alsadat Seyedian Maryam Mehrpooya Davoud Ahmadimoghaddam Mahtabalsadat Mirjalili Masood Ghiasian Source Type: research

N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial
CONCLUSIONS: This study suggested that NAC might be a relevant candidate for adjunct therapy in managing acute lumbar radiculopathy. Additional clinical trials are needed to validate these findings.TRIAL REGISTRATION: The trial was registered at Clinicaltrials.gov (identifier code: IRCT2012021 5009014N381). Registration date: 2021-02-06.PMID:37779397 | DOI:10.2174/0115748871250545230919055109 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - October 2, 2023 Category: Cancer & Oncology Authors: Bijan Heidari Zeinab-Alsadat Seyedian Maryam Mehrpooya Davoud Ahmadimoghaddam Mahtabalsadat Mirjalili Masood Ghiasian Source Type: research

N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial
CONCLUSIONS: This study suggested that NAC might be a relevant candidate for adjunct therapy in managing acute lumbar radiculopathy. Additional clinical trials are needed to validate these findings.TRIAL REGISTRATION: The trial was registered at Clinicaltrials.gov (identifier code: IRCT2012021 5009014N381). Registration date: 2021-02-06.PMID:37779397 | DOI:10.2174/0115748871250545230919055109 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - October 2, 2023 Category: Cancer & Oncology Authors: Bijan Heidari Zeinab-Alsadat Seyedian Maryam Mehrpooya Davoud Ahmadimoghaddam Mahtabalsadat Mirjalili Masood Ghiasian Source Type: research

N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial
CONCLUSIONS: This study suggested that NAC might be a relevant candidate for adjunct therapy in managing acute lumbar radiculopathy. Additional clinical trials are needed to validate these findings.TRIAL REGISTRATION: The trial was registered at Clinicaltrials.gov (identifier code: IRCT2012021 5009014N381). Registration date: 2021-02-06.PMID:37779397 | DOI:10.2174/0115748871250545230919055109 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - October 2, 2023 Category: Cancer & Oncology Authors: Bijan Heidari Zeinab-Alsadat Seyedian Maryam Mehrpooya Davoud Ahmadimoghaddam Mahtabalsadat Mirjalili Masood Ghiasian Source Type: research