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High concentrations of commonly used drugs can inhibit the in vitro glucuronidation of bisphenol A and nonylphenol in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to identify and characterize the potential metabolic interactions between 14 drugs and these two endocrine disruptors. Nonylphenol and bisphenol A were co-incubated in freshly isolated rat hepatocytes with, drugs at a high concentration. Statistically significant metabolic inhibition of bisphenol A and nonylphenol biotransformation was observed with nine drugs (>50% inhibition by naproxen, salicylic acid, carbamazepine and mefenamic acid). Inhibition assays of UGT activity in rat liver microsomes revealed: 1) competitive inhibition by naproxen (K(i)(app) = 848.3 muM) and carbamazepine (K(i)(app) = 1023....
Source: Xenobiotica - November 16, 2009 Category: Research Authors: Verner MA, Magher T, Haddad S Tags: Xenobiotica Source Type: journals

Painkillers May Fight Alzheimer's DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A study in mice shows that taking Advil and Aleve could help prevent Alzheimer's disease if they are taken early enough. (Source: WDSU.com - Health)
Source: WDSU.com - Health - November 10, 2009 Category: Consumer Health News Authors: WDSU.com Source Type: news

NSAIDs Prevent Early Sign Of Alzheimer Disease In MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
If taking nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen or naproxen is to protect you from developing Alzheimer disease then you will have to start taking them at a very early age according to research in a mouse model of the disease. Emerging data indicate that an early molecular event in the development of Alzheimer disease is the induction of neuronal cell cycle events (CCEs). (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - November 10, 2009 Category: Biochemistry Tags: Alzheimer's / Dementia Source Type: news

NSAIDs Prevent Early Sign Of Alzheimer Disease In MiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
If taking nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen or naproxen is to protect you from developing Alzheimer disease then you will have to start taking them at a very early age according to research in a mouse model of the disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 10, 2009 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news

New Combination Drug Improves Gastroprotection, Adherence Compared With EC Naproxen AloneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Enteric-coated naproxen 500 mg + immediate-release esomeprazole 20 mg improves gastrointestinal symptoms, and the fixed-dose combination promotes adherence to long-term NSAID therapy. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 6, 2009 Category: Consumer Health News Tags: Gastroenterology Source Type: news

Modeling the influence of cyclodextrins on oral absorption of low solubility drugs: II. Experimental validationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A model was developed for predicting the influence of cyclodextrins (CDs) delivered as a physical mixture with drug on oral absorption. CDs are cyclic oligosaccharides which form inclusion complexes with many drugs and are often used as solubilizing agents. The purpose of this work is to compare the simulation predictions with in vitro as well as in vivo experimental results to test the model's ability to capture the influence of CD on key processes in the gastrointestinal (GI) tract environment. Dissolution and absorption kinetics of low solubility drugs (Naproxen and Nifedipine) were tested in the presence and absence of...
Source: Biotechnology and Bioengineering - November 1, 2009 Category: Biomedical Science Authors: Ece Dilber Gamsiz, Lee Miller, Avinash G. Thombre, Imran Ahmed, Rebecca Lyn Carrier Source Type: journals

Nonsteroidal anti-inflammatory drug hypersensitivity syndrome. A multicenter study. I. Clinical findings and in vitro diagnosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: BAT seems particularly indicated in patients with a clinical history of NSAID intolerance, and in whom a provocation test is not advisable for ethical, clinical, or other reasons. Clear-cut positive results can be considered as confirming a history of NSAID hypersensitivity, although negative results may not exclude it. PMID: 19862935 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)
Source: Journal of Investigational Allergology & Clinical Immunology - October 31, 2009 Category: Allergy & Immunology Authors: De Weck AL, Sanz ML, Gamboa PM, Aberer W, Blanca M, Correia S, Erdman S, Jermann JM, Kanny G, Kowalski M, Mayorga L, Medrala W, Merk A, Sturm GJ, Sainte-Laudy J, Schneider MS, Sczczeklik A, Weber JM, Wedi A Tags: J Investig Allergol Clin Immunol Source Type: journals

Merck Never Believed In Naproxen Protection, Shareholders ClaimEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
WASHINGTON, D.C. - Merck & Co. Inc. misled investors by claiming to believe the generic painkiller naproxen had prevented cardiovascular problems in a study, the representative of class asserting shareholder claims in an Oct. 19 brief before the U.S. Supreme Court, when the company had no proof for the "naproxen theory" and knew much earlier that Vioxx contributed to heart attacks and strokes (Merck & Co., Inc., et al. v. Richard Reynolds, et al., No. 08-905, U.S. Sup.; See August 2009, Page 10). Full story on lexis.com (Source: LexisNexis® Mealey's™ Arthritis Drugs Legal News)
Source: LexisNexis® Mealey's™ Arthritis Drugs Legal News - October 29, 2009 Category: Medical Law Source Type: info

Infusions of albumin increase free fraction of naproxen in healthy volunteers: a randomized crossover studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In vitro and in vivo studies have indicated that stabilizers present in pharmaceutical-grade albumin influence the albumin-binding capacity for highly protein-bound drugs. However, the half-life of the stabilizers and the quantitative effect have been difficult to determine. A randomized crossover study including six healthy volunteers was performed. The study subjects received 750 mg of oral naproxen 2 h before the study. They were randomized to receive either 100 ml of 20% albumin or 100 ml of Ringer's acetate solution intravenously. Frequent blood samples were obtained. The experiment was repeated 4 weeks later with the...
Source: Acta Anaesthesiologica Scandinavica - October 29, 2009 Category: Anesthesiology Authors: P. A. REINE, U. E. KONGSGAARD, A. ANDERSEN, A.-K. THØGERSEN, H. OLSEN Source Type: journals

Logical Therapeutics Announces Positive Results Of LT-NS001 Vs. Naproxen Clinical StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Logical Therapeutics, Inc., a Waltham, MA-based biopharmaceutical company announced the positive results of a Phase I/II clinical trial evaluating the gastrointestinal (GI) safety of its investigational drug LT-NS001, the first of a new class of bio-activated prodrugs being developed for the chronic treatment of arthritic conditions. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 28, 2009 Category: Consumer Health News Tags: GastroIntestinal / Gastroenterology Source Type: news

Logical Therapeutics Announces Positive Results of LT-NS001 vs. Naproxen Clinical StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bio-activated Prodrug Demonstrates Significant Reduction in Incidence of GI Ulcers and Erosions SAN DIEGO - October 27, 2009 - Logical Therapeutics, Inc., a Waltham, MA-based biopharmaceutical company announced today the positive results of a... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - October 27, 2009 Category: Pharmaceuticals Source Type: clinical trials

Can l(+)-lactate be used as a marker of experimentally induced inflammation in rats?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our results suggest that lactate may be useful as an additional biomarker of inflammatory processes, especially for monitoring the non-cox-inhibitor sensitive cascade. Content Type Journal ArticleCategory Original Research PaperDOI 10.1007/s00011-009-0107-6Authors Anja Finn, AstraZeneca R&D Södertälje Disease Biology, Local Discovery Research Area CNS and Pain Control 151 85 Södertälje SwedenSandra Claudine Oerther, AstraZeneca R&D Södertälje Disease Biology, Local Discovery Research Area CNS and Pain Control 151 85 Södertälje Sweden Journal Inflammation ResearchOnline ISSN 14...
Source: Inflammation Research - October 27, 2009 Category: Research Tags: Inflammation Research Source Type: journals

ACG: Low-Dose Naproxen Increases Ulcer Risk (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAN DIEGO (MedPage Today) -- Even at low doses, naproxen (Aleve, Anaprox, Naprosyn, Naprelan) may increase the risk of upper gastrointestinal complications, researchers said. (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - October 26, 2009 Category: Gastroenterology Source Type: news

Naproxen/turmeric: Peptic ulcers: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 26, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

NAPROXEN SODIUMtablet [AvKARE, Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 23, 2009 Category: Drugs & Pharmacology Source Type: organizations

Missouri Town Requires Prescriptions for Cold, Allergy MedicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Union, Mo., just became the second town in the U.S. to pass a law that requires a prescription to buy (formerly) over-the-counter cold and allergy medicines such as Sudafed, Aleve Cold & Sinus and Claritin D, which contain the methamphetamine ingredient pseudoephedrine. (Source: Alcohol, Tobacco and Other Drugs News)
Source: Alcohol, Tobacco and Other Drugs News - October 22, 2009 Category: Addiction Source Type: news

Degradation and adsorption of selected pharmaceuticals and personal care products (PPCPs) in agricultural soils.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, adsorption and degradation of six selected PPCPs, including clofibric acid, ibuprofen, naproxen, triclosan, diclofenac and bisphenol A have been investigated in the laboratory using four US agricultural soils associated with reclaimed wastewater reuse. Adsorption test using a batch equilibrium method demonstrated that adsorption of all tested chemicals in soils could be well described with Freundlich equation, and their adsorption affinity on soil followed the order of triclosan>bisphenol A>clofibric acid>naproxen>diclofenac>ibuprofen. Retardation factor (R(F)) suggested that ibuprofen had pot...
Source: Chemosphere - October 21, 2009 Category: Chemistry Authors: Xu J, Wu L, Chang AC Tags: Chemosphere Source Type: journals

NAPRELAN (Naproxen Sodium) Tablet, Film Coated, Extended Release NAPRELAN (Naproxen Sodium) Kit [Victory Pharma, Inc. ]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

Amlodipine/colchicine/naproxen sodium: Suicide attempt: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 19, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Proteomic analysis in NSAIDs-Treated primary cardiomyocytes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we tried to identify proteins responding to the cellular toxicity in NSAIDs-treated primarily cultured cardiomyocytes using 2-D proteomic analysis. We used seven different NSAIDs (celecoxib, rofecoxib, valdecoxib, diclofenac, naproxen, ibuprofen, meloxicam) possessing each different degree of cardiovascular risk. Overall protein spots were similar in all NSAIDs-treated cells although numbers of decreased proteins were about 2-fold higher in celecoxib or rofecoxib-treated cells than in cells incubated with other NSAIDs. Many stress-related proteins, cardiac muscle movement proteins and proteins involving in m...
Source: Journal of Proteomics - October 19, 2009 Category: Biochemistry Authors: Baek SM, Ahn JS, Noh HS, Park J, Kang SS, Kim DR Tags: J Proteomics Source Type: journals

AstraZeneca Submits Marketing Authorisation Application to European Union for VimovoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
LONDON, Oct. 16, 2009-AstraZeneca and POZEN Inc. today announced that they have submitted a Marketing Authorisation Application (MAA) in the European Union via the Decentralised Procedure (DCP) for VIMOVO™ (enteric-coated naproxen/immediate... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 16, 2009 Category: Pharmaceuticals Source Type: news

Single dose oral flurbiprofen for acute postoperative pain in adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Flurbiprofen is a non-selective non-steroidal anti-inflammatory drug (NSAID), related to ibuprofen and naproxen, used to treat acute and chronic painful conditions. There is no systematic review of its use in acute postoperative pain. Objectives To assess efficacy, duration of action, and associated adverse events of single dose oral flurbiprofen in acute postoperative pain in adults. Search strategy We searched Cochrane CENTRAL, MEDLINE, EMBASE and the Oxford Pain Relief Database for studies to January 2009. Select...
Source: NeLM - Surgery - October 14, 2009 Category: Surgery Source Type: organizations

A novel second-order standard addition analytical method based on data processing with multidimensional partial least-squares and residual bilinearization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report discusses a modified second-order standard addition method, in which the test data matrix is subtracted from the standard addition matrices, and quantitation proceeds via the classical external calibration procedure. It is shown that this novel data processing method allows one to apply not only parallel factor analysis (PARAFAC) and multivariate curve resolution-alternating least-squares (MCR-ALS), but also the recently introduced and more flexible partial least-squares (PLS) models coupled to residual bilinearization (RBL). In particular, the multidimensional variant N-PLS/RBL is shown to produce the best ana...
Source: Analytica Chimica Acta - October 1, 2009 Category: Chemistry Authors: Lozano VA, Ibañez GA, Olivieri AC Tags: Anal Chim Acta Source Type: journals

Nanosizing of poorly water soluble compounds using rotation/revolution mixer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, nanoparticles of various poorly water soluble compounds were prepared by wet milling that was carried out using a rotation/revolution mixer and zirconia balls. To be compared with Beads mill, rotation/revolution mixer has superior in very quick process (5 min) and needs very few amounts of zirconia balls (2.4 g) for pulverizing drugs to nanometer range. Phenytoin, indomethacin, nifedipine, danazol, and naproxen were selected as the standard poorly water soluble compounds. Various parameters of the rotation/revolution mixer were studied to decide the optimal pulverization conditions for the production of nano...
Source: Chemical and Pharmaceutical Bulletin - September 30, 2009 Category: Drugs & Pharmacology Authors: Takatsuka T, Endo T, Jianguo Y, Yuminoki K, Hashimoto N Tags: Chem Pharm Bull (Tokyo) Source Type: journals

PPIs to Prevent NSAID-Induced GI UlcersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DR. EBBERT and DR. TANGALOS are with the Mayo Clinic in Rochester, Minn. They have no conflict of interest to report. A 57-year-old man with a history of coronary artery disease and severe degenerative joint disease status post right shoulder rotator cuff tear repair, right total knee arthroscopy, left knee meniscal tear repair, and three spinal fusions presents to you for pain management issues. He is on long-term narcotics with oxycodone. He presented 3 months earlier to the emergency department (ED) with dysphagia and odynophagia. His hemoglobin level was normal, and he denied gastrointestinal bleeding. At the time of ...
Source: Rheumatology News - September 30, 2009 Category: Rheumatology Authors: JON O. EBBERT, ERIC G. TANGALOS Source Type: journals

Hyperkalemia-Induced ParalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 60-year-old man who experienced paralysis presumably due to hyperkalemia. He presented to the emergency department with severe weakness in all extremities. The patient's serum potassium concentration was greater than 8 mEq/L and his serum creatinine concentration was 7 mg/dl. Findings on electrocardiography were abnormal. Of note, his drug therapy included lisinopril and naproxen. After treatment for hyperkalemia, the patient's symptoms resolved; however, he was admitted for further workup for renal failure. The patient was discharged after approximately 1 week with a diagnosis of end-stage renal disease. Use...
Source: Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy - September 29, 2009 Category: Drugs & Pharmacology Authors: Nikita S WilsonJoanna Q HudsonZachary CoxTabitha KingChristopher K Finch Source Type: journals

Quantitative estimation of naproxen in tablets using ibuprofen sodium as hydrotropic agentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Maheshwari R K, Wanare G, Chahar Nitika, Joshi Prajakta, Nayak NishiIndian Journal of Pharmaceutical Sciences 2009 71(3):335-337In the present investigation 0.5 M ibuprofen sodium solution has been used as hydrotropic solubilizing agent for naproxen, a poorly water-soluble drug and in it there was more than 350 fold enhancement in the solubility of naproxen as compared to the solubility in distilled water. Therefore, this hydrotropic solution was employed to extract out the drug from its tablet dosage form for quantitative estimation by titrimetry. The naproxen has been successfully analyzed in tablets. The results of anal...
Source: Indian Journal of Pharmaceutical Sciences - September 25, 2009 Category: Drugs & Pharmacology Authors: Maheshwari R K, Wanare G, Chahar Nitika, Joshi Prajakta, Nayak Nishi Source Type: journals

A Unique Presentation of Complex Regional Pain Syndrome Type I Treated with a Continuous Sciatic Peripheral Nerve Block and Parenteral Ketamine Infusion: A Case ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. This case suggests therapeutic benefit from aggressive treatment of both the peripheral and central components of CRPS. (Source: Pain Medicine)
Source: Pain Medicine - September 8, 2009 Category: Anesthesiology Authors: Adam Everett, Brian Mclean, Anthony Plunkett, Chester Buckenmaier Source Type: journals

Effects of the Cyclooxygenase Inhibiting Nitric Oxide Donator Naproxcinod Versus Naproxen on Systemic Blood Pressure in Patients With Osteoarthritis†Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Traditional nonsteroidal anti-inflammatory drugs are associated with the destabilization of blood pressure (BP) control, particularly in hypertensive patients treated with blockers of the renin-angiotensin system. To assess the potential impact of nitric oxide donation, the effects of naproxcinod with naproxen and placebo on changes in BP were compared in a randomized clinical trial of 916 patients with osteoarthritis after 13 weeks of therapy. In addition, the effects of naproxcinod versus naproxen and placebo on systolic BP in patients with hypertension treated with renin-angiotensin system blockers were evaluated. Napro...
Source: The American Journal of Cardiology - September 7, 2009 Category: Cardiology Authors: William B. White, Thomas J. Schnitzer, Rosanna Fleming, Brigitte Duquesroix, Maarten Beekman Tags: Systemic Hypertension Source Type: journals

Engineering and validation of a novel lipid thin film for biomembrane modeling in lipophilicity determination of drugs and xenobioticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The lipid film signifies a biomimetic artificial biological interface capable of both hydrophobic and specific electrostatic interactions. It captures the hydrophilic-lipophilic balance (HLB) in the determination of lipophilicity of molecules unlike the pure hydrocarbon film of the prior art. The potentials and performance of the bio-device gives the promise of its utility as a predictive analytic tool for early-stage drug discovery science. (Source: Journal of Biological Engineering)
Source: Journal of Biological Engineering - September 6, 2009 Category: Biotechnology Authors: Sunday IdowuMorenikeji AdeyemoUdochi Ogbonna Source Type: journals

POZEN Announces FDA Acceptance Of NDA For VIMOVO™Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
POZEN Inc. (NASDAQ:POZN), announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) for VIMOVO™ (enteric-coated naproxen / immediate release esomeprazole magnesium, formerly know as PN 400). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 2, 2009 Category: Consumer Health News Tags: Arthritis / Rheumatology Source Type: news

NAPROXEN TABLETS Tablet [Dr. Reddy'S Laboratories Limited]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 2, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 2, 2009 Category: Drugs & Pharmacology Source Type: organizations

Pozen Announces FDA Acceptance of NDA For VimovoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CHAPEL HILL, N.C.--(BUSINESS WIRE)--Aug 31, 2009 - POZEN Inc. today announced that the U.S. Food and Drug Administration (FDA) has accepted the New Drug Application (NDA) for Vimovo (enteric-coated naproxen / immediate release esomeprazole... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - September 1, 2009 Category: Drugs & Pharmacology Source Type: news

The use of selective cyclooxygenase-2 inhibitors and the risk of acute myocardial infarction in Saskatchewan, CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study showed a modest increased risk of AMI/CHD with various traditional NSAIDs and COX-2 inhibitors. Confidence intervals of estimated ORs included the null value for most comparisons. The study confirmed that the differentiation between traditional NSAIDs and COX-2 inhibitors is not a reliable tool for predicting cardiovascular risk associated with NSAIDs. Copyright © 2009 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - August 28, 2009 Category: Drugs & Pharmacology Authors: Cristina Varas-Lorenzo, Jordi Castellsague, Mary Rose Stang, Susana Perez-Gutthann, Jaume Aguado, Luis Alberto García Rodriguez Source Type: journals

Prevalence and impact of primary dysmenorrhea among Mexican high school studentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The prevalence of dysmenorrhea was high in our sample. The condition caused short-term school absences and the students commonly addressed it by self-medicating. (Source: International Journal of Gynaecology and Obstetrics)
Source: International Journal of Gynaecology and Obstetrics - August 28, 2009 Category: OBGYN Authors: Mario I. Ortiz, Eduardo Rangel-Flores, Lourdes C. Carrillo-Alarcón, Humberto A. Veras-Godoy Tags: Clinical articles Source Type: journals

A patient with osteoarthritis and cardiovascular disease presenting with bilateral hip pain: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The addition of a proton pump inhibitor to nonsteroidal anti-inflammatory drug therapy can reduce the risk of peptic ulcer bleeding by (equal to or greater than) 80%, making the incidence of gastropathy the same as with cyclooxygenase-2-specific inhibitors. The fact that naproxen is not associated with an increased risk of acute myocardial infarction made it an appropriate choice for this patient. (Source: Cases Journal)
Source: Cases Journal - August 23, 2009 Category: Journals (General) Source Type: journals

Removal of antibiotics and non-steroidal anti-inflammatory drugs by extended sludge age biological process.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Removal of four antibiotics (sulfamethoxazole, sulfadimethoxine, sulfamethazine and trimethoprim) and four non-steroidal anti-inflammatory drugs (acetaminophen, ibuprofen, ketoprofen and naproxen) using extended sludge age biological process was investigated. The sludge age of the biological system was greater than 200d. Hydraulic retention time of 12h was maintained throughout the experiment. The extended sludge age biological process is able to treat pharmaceuticals with good and steady removal efficiencies: 64-93% removal for antibiotics over 1-5mugL(-1) influent concentrations and 94% to complete removal for acetam...
Source: Chemosphere - August 20, 2009 Category: Chemistry Authors: Yu TH, Lin AY, Lateef SK, Lin CF, Yang PY Tags: Chemosphere Source Type: journals

A conditional sequential sampling procedure for drug safety surveillanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We propose a practical group sequential method, a conditional sequential sampling procedure, to test if a drug of interest (D) leads to an elevated risk for an adverse event E compared with a comparison drug C. The method is designed for prospective drug safety surveillance studies, in which, for each considered drug, a summary table with the exposed person-times and the associated numbers of adverse events summed by strata defined by several potential confounders, is collected and updated periodically using the health plans' administrative claims data. This new approach can be applied to test for elevated relative risk wh...
Source: Statistics in Medicine - August 17, 2009 Category: Statistics Authors: Lingling Li Source Type: journals

Role of aromatic amino acid tryptophan UVA-photoproducts in the determination of drug photosensitization mechanism: a comparison between methylene blue and naproxenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alfio Catalfo, Giuseppina Bracchitta, Guido De Guidi (Paper from Photochem. Photobiol. Sci.) Alfio Catalfo, Photochem. Photobiol. Sci., 2009, DOI: 10.1039/b9PP00028c To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Photochem. Photobiol. Sci. latest articles)
Source: RSC - Photochem. Photobiol. Sci. latest articles - August 16, 2009 Category: Chemistry Authors: Alfio CatalfoGiuseppina Bracchitta Guido De Guidi Source Type: journals

Effects of Liquisolid Formulations on Dissolution of Naproxen.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to evaluate the effects of different formulation variables, i.e. type of non-volatile liquid vehicles and drug concentrations, on drug dissolution rates. The liquisolid tablets were formulated with three different liquid vehicles, namely Cremophor((R)) EL (polyoxyl 35 castor oil), Synperonic((R)) PE/L61 (poloxamer 181, polyoxyethylene-polyoxypropylene copolymer) and poly ethylene glycol 400 (PEG400) at two drug concentrations, 20%w/w and 40%w/w. Avicel((R)) PH102 was used as a carrier material, Cab-o-sil((R)) M-5 as a coating material and maize starch as a disintegrant. The empirical method as intro...
Source: European Journal of Pharmaceutics and Biopharmaceutics - August 9, 2009 Category: Drugs & Pharmacology Authors: Tiong N, Elkordy AA Tags: Eur J Pharm Biopharm Source Type: journals

Effects of Non-Steroidal Anti-Inflammatory Drugs on Abeta Deposition in Abeta(1-42) Transgenic C. elegans.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although epidemiological studies have shown that long-term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer's disease (AD), the mechanism(s) by which NSAIDs reduce the risk of AD remain to be determined. As C. elegans possess neither inflammatory cells nor the arachidonate cascade, we could evaluate the effects of NSAIDs on amyloid beta (Abeta) deposition in the absence of immune cells using Abeta-transgenic C. elegans. For this purpose, we established a strain of Abeta-transgenic C. elegans in which thioflavin S-reactive deposits are reproducibly detectable by confocal micros...
Source: Brain Research - August 6, 2009 Category: Neurology Authors: Morita M, Osoda K, Yamazaki M, Shirai F, Matsuoka N, Arakawa H, Nishimura S Tags: Brain Res Source Type: journals

Non-aspirin NSAIDs, cyclooxygenase-2 inhibitors and risk for cardiovascular events-stroke, acute myocardial infarction, and death from coronary heart diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To determine if certain non-steroidal anti-inflammatory drugs (NSAIDs) are associated with increased risk of cardiovascular events: acute myocardial infarction (AMI), stroke, and death from coronary heart disease (CHD).We conducted a retrospective cohort study of Tennessee Medicaid enrollees aged 35-94 years between 1 January 1999 and 31 December 2005. Eligible persons were non-institutionalized, had continuous enrollment, and had no serious illness prior to cohort entry. Exposure to celecoxib, rofecoxib, valdecoxib, ibuprofen, naproxen, diclofenac, and indomethacin was studied. The outcome was hospitalization for AMI, str...
Source: Pharmacoepidemiology and Drug Safety - July 27, 2009 Category: Drugs & Pharmacology Authors: Christianne L. Roumie, Neesha N. Choma, Lisa Kaltenbach, Edward F. Mitchel, Jr, Patrick G. Arbogast, Marie R. Griffin Source Type: journals

Doxycycline/levofloxacin/naproxen: Fatal hepatitis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - July 26, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Naproxen: Pustular eruption in a child: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - July 19, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Naproxen: Pustular eruption in a child: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 22 (Source: Reactions Weekly)
Source: Reactions Weekly - July 18, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Naproxen May Help Prevent Alzheimer'sEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Naproxen May Help Prevent Alzheimer'sCategory: Health NewsCreated: 7/17/2009Last Editorial Review: 7/17/2009 (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - July 17, 2009 Category: Cardiology Source Type: consumer

Naproxen May Help Prevent Alzheimer'sEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Naproxen May Help Prevent Alzheimer'sCategory: Health NewsCreated: 7/17/2009Last Editorial Review: 7/17/2009 (Source: MedicineNet Cholesterol General)
Source: MedicineNet Cholesterol General - July 17, 2009 Category: Cardiology Source Type: consumer

Naproxen May Help Prevent Alzheimer'sEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Naproxen May Help Prevent Alzheimer'sCategory: Health NewsCreated: 7/17/2009Last Editorial Review: 7/17/2009 (Source: MedicineNet Senior Health General)
Source: MedicineNet Senior Health General - July 17, 2009 Category: Geriatrics Source Type: consumer

Naproxen May Help Prevent Alzheimer'sEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Naproxen May Help Prevent Alzheimer'sCategory: Health NewsCreated: 7/17/2009Last Editorial Review: 7/17/2009 (Source: MedicineNet Alzheimer)
Source: MedicineNet Alzheimer - July 17, 2009 Category: Geriatrics Source Type: consumer