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Appropriate evidence-based data overviews demonstrate the diagnostic and prognostic performances of FibroTest in patients with chronic hepatitis C: authors' replyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - November 2, 2009 Category: Drugs & Pharmacology Authors: J. O. Smith, R. K. Sterling Tags: Letters to the Editors Source Type: journals

Appropriate evidence-based data overviews demonstrate the diagnostic and prognostic performances of FibroTest in patients with chronic hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - November 2, 2009 Category: Drugs & Pharmacology Authors: T. Poynard, M. Munteanu, Y. Ngo, V. Ratziu Tags: Letters to the Editors Source Type: journals

Factors associated with radiation exposure in patients with inflammatory bowel diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Diagnosis of CD, IBD-related surgery, prednisone use, first year of diagnosis and age on the upper quartile are independent predictors of increased exposure in IBD patients. Alternative investigations which do not require radiation exposure should be considered for patients at risk for increased radiation exposure. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - November 2, 2009 Category: Drugs & Pharmacology Authors: Z. LEVI, A. FRASER, R. KRONGRAD, R. HAZAZI, O. BENJAMINOV, J. MEYEROVITCH, O. B. TAL, A. CHOEN, Y. NIV, G. FRASER Tags: Original articles Source Type: journals

Systematic review: the effects of conservative and surgical treatment for obesity on gastro-oesophageal reflux diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Dietary and lifestyle intervention may improve GERD in obese patients; however, the most favourable effect is likely to be found after bariatric surgery, especially after Roux-en-Y gastric bypass. Future studies need to elucidate for which GERD patients laparoscopic adjustable gastric banding might have a beneficial effect and how they can be identified preoperatively. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - November 1, 2009 Category: Drugs & Pharmacology Authors: N. L. DE GROOT, J. S. BURGERHART, P. C. VAN DE MEEBERG, D. R. DE VRIES, A. J. P. M. SMOUT, P. D. SIERSEMA Tags: Systematic review Source Type: journals

Systematic review: endoscopic and imaging-based techniques in the assessment of portal haemodynamics and the risk of variceal bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Endoscopic and imaging-based measurements of portal haemodynamics provide an alternate means for the assessment of complications of portal hypertension. Further studies are required to validate their use in risk stratification and the evaluation of drug therapies in patients with portal hypertension. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - October 20, 2009 Category: Drugs & Pharmacology Authors: S. N. SGOUROS, K. V. VASILIADIS, S. P. PEREIRA Tags: Systematic review Source Type: journals

Generalized anxiety disorder and irritable bowel syndrome: authors' replyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - October 19, 2009 Category: Drugs & Pharmacology Authors: S. Lee, J. Wu, Y. L. Ma, A. Tsang, W.-J. Guo, J. Sung Tags: Letters to the Editors Source Type: journals

Generalized anxiety disorder and irritable bowel syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - October 19, 2009 Category: Drugs & Pharmacology Authors: A. C. Ford Tags: Letters to the Editors Source Type: journals

Review article: the modern management of portal vein thrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Role of anticoagulation in chronic portal vein thrombosis needs to be further studied. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - October 7, 2009 Category: Drugs & Pharmacology Authors: Y. CHAWLA, A. DUSEJA, R. K. DHIMAN Tags: Review article Source Type: journals

Azathioprine plus ribavirin treatment and pancytopeniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - October 5, 2009 Category: Drugs & Pharmacology Authors: M. Chaparro, M. Trapero-Marugán, R. Moreno-Otero, J. P. Gisbert Tags: Letters to the Editors Source Type: journals

Saccharomyces boulardii for treating acute gastroenteritis in children: updated meta-analysis of randomized controlled trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - October 5, 2009 Category: Drugs & Pharmacology Authors: H. Szajewska, A. Skórka Tags: Letters to the Editors Source Type: journals

Inaccurate endoscopy: a better explanation for placebo-associated endoscopic ulcers: authors' replyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - October 5, 2009 Category: Drugs & Pharmacology Authors: Y. Yuan, Y.-H. Yuan, C. Wang, R. H. Hunt Tags: Letters to the Editors Source Type: journals

Inaccurate endoscopy: a better explanation for placebo-associated endoscopic ulcersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - October 5, 2009 Category: Drugs & Pharmacology Authors: D. Y. Graham, F. K. L. Chan Tags: Letters to the Editors Source Type: journals

Prevalence of hepatitis B virus DNA polymerase mutations in treatment-naïve patients with chronic hepatitis BEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions No rtM204V/I or rtN236T mutations were observed in our study. Less than 1% of our patients had mutations that can be associated with primary resistance to existing anti-viral therapies for hepatitis B virus. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 24, 2009 Category: Drugs & Pharmacology Authors: M. H. NGUYEN, R. T. GARCIA, H. N. TRINH, H. A. NGUYEN, K. K. NGUYEN, L. H. NGUYEN, B. LEVITT Tags: Original articles Source Type: journals

An investigation of medication adherence to 5-aminosalicylic acid therapy in patients with ulcerative colitis, using self-report and urinary drug excretion measurementsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our observations confirm the difficulty of accurately assessing medication adherence. Nonmodifiable (younger age, South Asian ethnicity) and potentially modifiable (medication beliefs) predictors of non-adherence were identified. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 24, 2009 Category: Drugs & Pharmacology Authors: T. MOSHKOVSKA, M. A. STONE, J. CLATWORTHY, R. M. SMITH, J. BANKART, R. BAKER, J. WANG, R. HORNE, J. F. MAYBERRY Tags: Original articles Source Type: journals

Clinical trial: the efficacy and safety of routine bowel cleansing agents for elective colonoscopy in persons with spinal cord injury – a randomized prospective single-blind studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Neither OSPS alone, PEG alone nor their combination was sufficient to prepare adequately the bowel for colonoscopy in most patients with spinal cord injury. However, administration of OSPS and/or PEG appears to be safe in the spinal cord injury population, provided adequate hydration is provided. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 21, 2009 Category: Drugs & Pharmacology Authors: H. R. ANCHA, A. M. SPUNGEN, W. A. BAUMAN, A. S. ROSMAN, S. SHAW, K. K. HUNT, J. B. POST, M. GALEA, M. A. KORSTEN Tags: Clinical trial Source Type: journals

Systematic review: caspase-cleaved fragments of cytokeratin 18 – the promises and challenges of a biomarker for chronic liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Undoubtedly, the most promising application of CK18 fragments is currently in nonalcoholic fatty liver disease, and especially for distinguishing patients with nonalcoholic steatohepatitis vs. those with simple steatosis. Further investigations and technical improvements are required to cross the boundary from research to the clinical application of CK18 fragments as a marker of chronic liver disease. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 21, 2009 Category: Drugs & Pharmacology Authors: Y. YILMAZ Tags: Systematic review Source Type: journals

Review article: Helicobacter pylori-negative duodenal ulcer diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background Helicobacter pylori infection rates in duodenal ulcer (DU) patients may be lower than previously estimated.Aim To review the real prevalence of H. pylori-negative DUs and its possible causes.Methods Bibliographical searches in MEDLINE looking for the terms 'H. pylori' and 'duodenal ulcer'.Results Mean prevalence of H. pylori infection in DU disease, calculated from studies published during the last 10 years including a total of 16 080 patients, was 81%, and this figure was lower (77%) when only the last 5 years were considered. Associations with H. pylori-negative DU were: (1) False negative results of diagnosti...
Source: Alimentary Pharmacology and Therapeutics - September 16, 2009 Category: Drugs & Pharmacology Authors: J. P. GISBERT, X. CALVET Tags: Review article Source Type: journals

Tumour necrosis factor antagonists and inflammatory bowel diseases: a national practice surveyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The attitudes of French gastroenterologists generally reflect the recommendations regarding the use of anti-TNF and concomitant immunosuppressive therapy in IBD. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 15, 2009 Category: Drugs & Pharmacology Authors: A. OUSSALAH, X. ROBLIN, D. LAHARIE, J. FILIPPI, M. FLAMANT, P. FAURE, J.-M. PHELIP, M.-A. BIGARD, L. PEYRIN-BIROULET Tags: Original articles Source Type: journals

Measuring irritable bowel syndrome patient-reported outcomes with an abdominal pain numeric rating scaleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions An abdominal pain NRS exhibits excellent validity and can be readily interpreted with a minimal clinically important difference in patients with IBS. These data support the use of the NRS in IBS clinical trials. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 12, 2009 Category: Drugs & Pharmacology Authors: B. SPIEGEL, R. BOLUS, L. A. HARRIS, S. LUCAK, B. NALIBOFF, E. ESRAILIAN, W. D. CHEY, A. LEMBO, H. KARSAN, K. TILLISCH, J. TALLEY, E. MAYER, L. CHANG Tags: Original articles Source Type: journals

Synergistic association between alcohol intake and body mass index with serum alanine and aspartate aminotransferase levels in older adults: the Rancho Bernardo StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In older men and women, the combination of obesity with alcohol is synergistic in increasing the risk of liver injury. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 8, 2009 Category: Drugs & Pharmacology Authors: R. LOOMBA, R. BETTENCOURT, E. BARRETT-CONNOR Tags: Original articles Source Type: journals

Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary careEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The GerdQ is a potentially useful tool for family practitioners and other health care professionals in diagnosing and managing GERD without initial specialist referral or endoscopy. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 7, 2009 Category: Drugs & Pharmacology Authors: R. JONES, O. JUNGHARD, J. DENT, N. VAKIL, K. HALLING, B. WERNERSSON, T. LIND Tags: Original articles Source Type: journals

Withdrawal of corticosteroids in inflammatory bowel disease patients after dependency periods ranging from 2 to 45 years: a proposed methodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Corticosteroid withdrawal using this protocol had a high success rate and durable effect and was effective in patients with long-standing (up to 45 years) dependency. As symptoms of CWS mimic symptoms of IBD disease flares, gastroenterologists may have difficulty distinguishing them, which may be a contributory factor to the frequency of corticosteroid dependency in IBD patients. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 3, 2009 Category: Drugs & Pharmacology Authors: S. J. MURPHY, L. WANG, L. A. ANDERSON, A. STEINLAUF, D. H. PRESENT, J. I. MECHANICK Tags: Original articles Source Type: journals

Endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of solid pancreatic masses: the impact on patient-management strategyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In patients with pancreatic mass and suspected malignancy, EUS-FNA provides an accurate diagnosis in approximately 80% of cases. EUS-FNA directly influences the management in two-thirds of patients. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 3, 2009 Category: Drugs & Pharmacology Authors: Y. TOUCHEFEU, M. LE RHUN, E. CORON, A. ALAMDARI, M. F. HEYMANN, J. F. MOSNIER, T. MATYSIAK, J. P. GALMICHE Tags: Original articles Source Type: journals

Safety profile of dexlansoprazole MR, a proton pump inhibitor with a novel dual delayed release formulation: global clinical trial experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Dexlansoprazole MR 30[ndash]90 mg has a safety profile comparable to that of lansoprazole. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 3, 2009 Category: Drugs & Pharmacology Authors: D. A. PEURA, D. C. METZ, A. H. DABHOLKAR, M. M. PARIS, P. YU, S. N. ATKINSON Tags: Original articles Source Type: journals

Review article: gastric electrical stimulation for gastroparesis – physiological foundations, technical aspects and clinical implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Gastric electrical stimulation is a helpful intervention in recalcitrant gastroparesis. Controlled studies and better understanding of mechanisms of action of electrical stimulation are needed to evaluate further the clinical utility of this intervention and to exploit its therapeutic potential better. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 3, 2009 Category: Drugs & Pharmacology Authors: E. SOFFER, T. ABELL, Z. LIN, A. LORINCZ, R. MCCALLUM, H. PARKMAN, S. POLICKER, T. ORDOG Tags: Review article Source Type: journals

Rotterdam score predicts early mortality in Budd-Chiari syndrome, and surgical shunting prolongs transplant-free survivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Rotterdam score is the best discrimination index for 3-month mortality in Budd[ndash]Chiari syndrome and should be used preferentially to determine treatment urgency. Surgical shunts constitute an important therapeutic modality that may help save liver grafts and prolong transplantation-free survival in a selected group of patients with Budd[ndash]Chiari syndrome. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 31, 2009 Category: Drugs & Pharmacology Authors: A. J. MONTANO-LOZA, P. TANDON, N. KNETEMAN, R. BAILEY, V. G. BAIN Tags: Original articles Source Type: journals

Uncomplicated peptic ulcer in the UK: trends from 1997 to 2005Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion A reduction in H. pylori-related peptic ulcers, changing patterns in NSAID use and increasing PPI use may have contributed to a decline in uncomplicated peptic ulcer incidence in the UK. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 25, 2009 Category: Drugs & Pharmacology Authors: S. CAI, L. A. GARCÍA RODRÍGUEZ, E. L. MASSÓ-GONZÁLEZ, S. HERNÁNDEZ-DÍAZ Tags: Original articles Source Type: journals

A single dose of intravenous esomeprazole decreases gastric secretion in healthy volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background Data suggest that esomeprazole decreases gastric secretion.Aims To assess the effect of a single i.v. esomeprazole dose on gastric secretion volume 3 h after drug administration, as a primary endpoint, and to evaluate, as secondary endpoints, the reduction 1 and 5 h after dosing; time when the gastric pH was (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 20, 2009 Category: Drugs & Pharmacology Authors: C. NICHITA, A. E.-W. ABDOU, P. MAERTEN, M. HERRANZ, N. MOURET, C. THALMANN, P. F. MICHETTI, G. DORTA Tags: Original articles Source Type: journals

Clinical trial: the impact of cyclooxygenase inhibitors on gastrointestinal recovery after major surgery – a randomized double blind controlled trial of celecoxib or diclofenac vs. placeboEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Perioperative low dose celecoxib, but not diclofenac, markedly reduced the development of paralytic ileus following major abdominal surgery, but did not accelerate early recovery of bowel function. This was independent of narcotic use and had no increase in post-operative complications. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 19, 2009 Category: Drugs & Pharmacology Authors: D. A. WATTCHOW, D. DE FONTGALLAND, P. A. BAMPTON, P. L. LEACH, K. MCLAUGHLIN, M. COSTA Tags: Clinical trial Source Type: journals

Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The pathogenesis of NSAID-induced peptic ulcers is complex and multifactorial. Recent advances in cellular and molecular biology have highlighted the importance of various prostaglandin-independent mechanisms. Pharmacogenetic studies may provide further insights into the pathogenetic mechanisms of NSAID-induced ulcers and help identify patients at increased risk. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 18, 2009 Category: Drugs & Pharmacology Authors: C. MUSUMBA, D. M. PRITCHARD, M. PIRMOHAMED Tags: Review article Source Type: journals

Factors influencing long-term changes in mental health after interferon-alpha treatment of chronic hepatitis CEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Pre-existing psychiatric risk factors increase the chance for a long-term improvement and reduce the risk for a long-term worsening of mental health after antiviral treatment of chronic hepatitis C with IFN-[alpha]. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 17, 2009 Category: Drugs & Pharmacology Authors: F. SCHMIDT, G. JANSSEN, G. MARTIN, R. LORENZ, K. LOESCHKE, M. SOYKA, C. FOLWACZNY, M. SCHAEFER Tags: Original articles Source Type: journals

Clinical trial: a nutritional supplement Viusid, in combination with diet and exercise, in patients with nonalcoholic fatty liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our results indicate that treatment with diet and exercise leads to a notable improvement in the histological features of NAFLD; however, the administration of Viusid intensifies the improvements of histological findings, especially of steatosis and inflammation. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 17, 2009 Category: Drugs & Pharmacology Authors: E. VILAR GOMEZ, A. RODRIGUEZ DE MIRANDA, B. GRA ORAMAS, E. ARUS SOLER, R. LLANIO NAVARRO, L. CALZADILLA BERTOT, A. YASELLS GARCIA, M. DEL ROSARIO ABREU VAZQUEZ Tags: Clinical trial Source Type: journals

5-hydroxytryptamine signalling in irritable bowel syndrome with diarrhoea: effects of gender and menstrual statusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Similar to IBS-D women with high P/O levels, IBS-D men also have raised PDP 5-HT concentrations. 5-HT concentration normalizes at menses in IBS-D women, suggesting a shift in the mechanisms responsible for abnormal 5-HT signalling in these patients. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 17, 2009 Category: Drugs & Pharmacology Authors: L. A. HOUGHTON, H. BROWN, W. ATKINSON, J. MORRIS, C. FELL, P. J. WHORWELL, S. LOCKHART, B. KEEVIL Tags: Original articles Source Type: journals

Clinical trial: efficacy and safety of dexlansoprazole MR 60 and 90 mg in healed erosive oesophagitis – maintenance of healing and symptom reliefEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Dexlansoprazole MR effectively maintained healed erosive oesophagitis and symptom relief compared with placebo, and was well tolerated. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 13, 2009 Category: Drugs & Pharmacology Authors: C. W. HOWDEN, L. M. LARSEN, M. C. PEREZ, R. PALMER, S. N. ATKINSON Tags: Clinical trial Source Type: journals

Effects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Oral 5 mg bisacodyl accelerates ascending colon in the unprepared colon in healthy adults; this action may contribute to the drug's efficacy in constipation. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 11, 2009 Category: Drugs & Pharmacology Authors: N. MANABE, F. CREMONINI, M. CAMILLERI, W. J. SANDBORN, D. D. BURTON Tags: Original articles Source Type: journals

Clinical trial: ulcerative colitis maintenance treatment with 5-ASA: a 1-year, randomized multicentre study comparing MMX® with Asacol®Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Once-daily 5-ASA-MMX is similarly effective with a comparable safety profile to Asacol administered twice daily, for the maintenance treatment of ulcerative colitis. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 11, 2009 Category: Drugs & Pharmacology Authors: C. PRANTERA, A. KOHN, M. CAMPIERI, R. CAPRILLI, M. COTTONE, F. PALLONE, V. SAVARINO, G. C. STURNIOLO, M. VECCHI, A. ARDIA, S. BELLINVIA Tags: Clinical trial Source Type: journals

Review article: visceral hypersensitivity in irritable bowel syndrome: molecular mechanisms and therapeutic agentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion It is anticipated that with advancing molecular understanding of the basis of visceral hypersensitivity, the next decade will see accelerated development of new molecules for treatment of functional bowel diseases. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - August 4, 2009 Category: Drugs & Pharmacology Authors: A. AKBAR, J. R. F. WALTERS, S. GHOSH Tags: Review article Source Type: journals

The GABAB receptor agonist AZD9343 inhibits transient lower oesophageal sphincter relaxations and acid reflux in healthy volunteers: a phase I studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Like baclofen, AZD9343 dose-dependently decreases the number of TLESRs and acid reflux episodes, increases LES pressure and reduces swallowing, extending the concept that GABAB agonists are potent reflux inhibitors. However, discovery of analogues with an improved side effect profile is warranted. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 23, 2009 Category: Drugs & Pharmacology Authors: H. BEAUMONT, A. SMOUT, M. AANEN, H. RYDHOLM, A. LEI, A. LEHMANN, M. RUTH, G. BOECKXSTAENS Tags: Original articles Source Type: journals

Prospective study of the effects of concomitant medications on thiopurine metabolism in inflammatory bowel diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our data suggest the absence of significant interactions between thiopurines and 5-ASA. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 23, 2009 Category: Drugs & Pharmacology Authors: M. DAPERNO, R. SOSTEGNI, R. CANAPARO, L. SERPE, A. LAVAGNA, L. CROCELLÀ, F. CASTAGNO, A. VERNETTO, C. RIGAZIO, E. ERCOLE, S. D'ANTICO, A. PERA, G. ZARA, R. ROCCA Tags: Original articles Source Type: journals

High therapy adherence but substantial limitations to daily activities amongst members of the Dutch inflammatory bowel disease patients' organization: a patient empowerment studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This population-based study shows high therapy adherence, but low functional status in Dutch CCUVN-related IBD-patients. The high adherence rate in this present study could be an effect of CCUVN membership. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 22, 2009 Category: Drugs & Pharmacology Authors: J. E. BAARS, Z. ZELINKOVA, P. B. F. MENSINK, T. MARKUS, C. W. N. LOOMAN, E. J. KUIPERS, C. J. VAN DER WOUDE Tags: Original articles Source Type: journals

Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardiiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The multiple anti-inflammatory mechanisms exerted by S. boulardii provide molecular explanations supporting its effectiveness in intestinal inflammatory states. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 22, 2009 Category: Drugs & Pharmacology Authors: C. POTHOULAKIS Tags: Review article Source Type: journals

Review article: nuclear receptors and liver disease – current understanding and new therapeutic implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The use of various nuclear receptor ligands in liver diseases is a promising approach that can benefit many patients suffering from these devastating diseases. However, we are far from a full understanding of the molecular mechanisms by which these receptors work. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 22, 2009 Category: Drugs & Pharmacology Authors: D. A. H. ELFAKI, E. BJORNSSON, K. D. LINDOR Tags: Review article Source Type: journals

Systematic review: the short-term and long-term efficacy of adalimumab following discontinuation of infliximabEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Current RCT and OLC evidence suggest that adalimumab is an efficacious therapy for CD patients who discontinue infliximab. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 21, 2009 Category: Drugs & Pharmacology Authors: C. MA, R. PANACCIONE, S. J. HEITMAN, S. M. DEVLIN, S. GHOSH, G. G. KAPLAN Tags: Systematic review Source Type: journals

Systematic review: adherence to a gluten-free diet in adult patients with coeliac diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The existing evidence for factors associated with non-adherence to a gluten-free diet is of variable quality. Further and more rigorous research is needed to characterize those individuals most likely to be non-adherent to assist them better with their treatment. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 20, 2009 Category: Drugs & Pharmacology Authors: N. J. HALL, G. RUBIN, A. CHARNOCK Tags: Systematic review Source Type: journals

Diverticular disease hospital admissions are increasing, with poor outcomes in the elderly and emergency admissionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Diverticular disease admissions increased over the course of the study. Patients of increasing age, admitted as emergency and significant comorbidity should be identified, allowing management modification to optimize outcomes. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 20, 2009 Category: Drugs & Pharmacology Authors: S. JEYARAJAH, O. FAIZ, A. BOTTLE, P. AYLIN, I. BJARNASON, P. P. TEKKIS, S. PAPAGRIGORIADIS Tags: Original articles Source Type: journals

CorrigendumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 19, 2009 Category: Drugs & Pharmacology Tags: Corrigendum Source Type: journals

Recent incidence trends and sociodemographic features of oesophageal and gastric cancer types in an English regionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background Oesophageal and gastric cancers comprise various common tumour types with possible different aetiology and historically different incidence trends.Aim To enhance and update evidence about the descriptive epidemiology of oesophageal and gastric cancers.Methods Population-based information from the East of England was available on 16 319 (65% male) incident cases of oesophago-gastric cancer (ICD-10 C150[ndash]169) diagnosed during 1995[ndash]2006. Age-standardized incidence trends by gender and deprivation groups and sex ratios were compared for four different tumour types [oesophageal squamous cell carcinoma (OSC...
Source: Alimentary Pharmacology and Therapeutics - July 17, 2009 Category: Drugs & Pharmacology Authors: C. GAJPERIA, J. M. BARBIERE, D. GREENBERG, K. WRIGHT, G. LYRATZOPOULOS Tags: Original articles Source Type: journals

Renal function and cardiovascular risk profile after conversion from ciclosporin to tacrolimus: prospective study in 80 liver transplant recipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Conversion from CS to TAC has been shown to improve the cardiovascular risk profile and may retard further decline of renal function after liver transplantation. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 17, 2009 Category: Drugs & Pharmacology Authors: S. BECKEBAUM, C. KLEIN, J. VARGHESE, G. C. SOTIROPOULOS, F. SANER, K. SCHMITZ, G. GERKEN, A. PAUL, V. R. CICINNATI Tags: Original articles Source Type: journals

Ascites improves upon plus serum sodium model for end-stage liver disease (MELD) for predicting mortality in patients with advanced liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The incorporation of radiographic ascites significantly improves upon MELDNa for predicting 1-year mortality. The presence of ascites may help identify patients at increased risk for mortality, not otherwise captured by either MELD or MELDNa. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 12, 2009 Category: Drugs & Pharmacology Authors: M. SOMSOUK, J. GUY, S. W. BIGGINS, E. VITTINGHOFF, M. A. KOHN, J. M. INADOMI Tags: Original articles Source Type: journals

Fentanyl vs. pethidine as sedation for gastrointestinal endoscopy: Author's reply to Hayee et al.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - July 9, 2009 Category: Drugs & Pharmacology Authors: D. J. Robertson Tags: Letters to the Editors Source Type: journals