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Avascular Necrosis of Bone in Leukemia and Osteonecrosis of Jaw by BisphosphonatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aseptic osteonecrosis, also known as avascular necrosis of bone or simply osteonecrosis (ON), is a disorder characterized by segmental death of 1 or more osseous sites due to a late toxicity of treatment for childhood leukemia and lymphoma. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - November 19, 2009 Category: ENT & OMF Authors: Enrico Nastro, Alessandro Allegra, Giacomo Oteri, Sebastiano Ferlito, Andrea Alonci, Giacomo Bellomo, Arianna D'Angelo, Annamaria Tolomeo, Domenico Cicciù, Francesco Saverio De Ponte, Caterina Musolino Tags: Letters to the Editor Source Type: journals

FEXOFENADINE HCL AND PSEUDOEPHEDRINE HCLtablet, Extended Release [Caremark LLC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 12, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 12, 2009 Category: Drugs & Pharmacology Source Type: organizations

Preoperative Multimodality Therapy Improves Disease-Free Survival in Patients With Carcinoma of the Rectum: NSABP R-03 [Gastrointestinal Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Preoperative chemoradiotherapy, compared with postoperative chemoradiotherapy, significantly improved DFS and showed a trend toward improved OS. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Roh, Colangelo, O'Connell, Yothers, Deutsch, Allegra, Kahlenberg, Baez-Diaz, Ursiny, Petrelli, Wolmark Tags: Chemotherapy Gastrointestinal Cancer Source Type: journals

A structure filter for the Eukaryotic Linear Motif ResourceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: New occurrences of known linear motifs require experimental validation as the bioinformatics tools currently have limited reliability. The ELM structure filter will aid users assessing candidate motifs presenting in globular structural regions. Most importantly, it will help users to decide whether to expend their valuable time and resources on experimental testing of interesting motif candidates. (Source: BMC Bioinformatics - Latest articles)
Source: BMC Bioinformatics - Latest articles - October 23, 2009 Category: Bioinformatics Authors: Allegra ViaCathryn GouldChristine GemundToby GibsonManuela Helmer-Citterich Source Type: journals

Application of antihistamines in ear, nose and throat disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was a review of the antihistamines (AH) in allergic rhinitis (AR). Most patients had comorbid ocular symptoms, asthma and anxiety. Fifty-five percent consulting for the first time were diagnosed with AR, of whom 2/3 also had conjunctivitis and 1/3 asthma. In other study 3/4 asthma patients had AR and 1/4 did not. Every five required in the preceding year a treatment in emergency departments. The routine use of antihistamines for treating otitis exudativa in children cannot be recommended. Antihistamines were the most commonly prescribed or recommended symptomatic medicines in sinusitis (1/4 of the patients). Abo...
Source: Articles of Advances in Dermatology and Allergology - TERMEDIA publishing house - October 19, 2009 Category: Dermatology Source Type: journals

Absence of the V617F JAK2 Mutation in the Lymphoid Compartment in a Patient with Essential Thrombo- cythemia and B-Chronic Lymphocytic Leukemia and in Two Relatives with Lymphoproliferative Disorders.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results seem to confirm that CLL cases are negative for JAK2(V617F) mutation in B- and T-lymphocyte populations.Presence of JAK2(V617F) mutation in subjects without myeloproliferative diseases could indicate an increased risk of a future myeloproliferative neoplasm development. PMID: 19816006 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - October 6, 2009 Category: Hematology Authors: Musolino C, Allegra A, Penna G, Centorrino R, Cuzzola M, D'Angelo A, Iacopino P, Alonci A Tags: Acta Haematol Source Type: journals

Drug interaction studies of gliquidone with fexofenadine, cetirizine, and levocetirizineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study thus supports the safe coadministration of gliquidone and H1-receptor blockers as an effective diabetic health management regimen. Content Type Journal ArticleCategory Original ResearchDOI 10.1007/s00044-009-9252-2Authors M. Saeed Arayne, University of Karachi Lab 9, Department of Chemistry Karachi 75270 PakistanNajma Sultana, University of Karachi Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy Karachi 75270 PakistanHina Shamshad, University of Karachi Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy Karachi 75270 PakistanAgha Zeeshan Mirza, University of Karachi Lab 9,...
Source: Medicinal Chemistry Research - September 30, 2009 Category: Chemistry Tags: Medicinal Chemistry Research Source Type: journals

Mechanistic Modeling of Hepatic Transport from Cells to Whole Body: Application to Napsagatran and FexofenadineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Molecular Pharmaceutics, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - September 28, 2009 Category: Drugs & Pharmacology Tags: article Source Type: journals

Impact of OATP transporters on pharmacokineticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Membrane transporters are now recognized as important determinants of the transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a family of influx transporters expressed in various tissues important for pharmacokinetics. Of the 11 human OATP transporters, OATP1B1, OATP1B3 and OATP2B1 are expressed on the sinusoidal membrane of hepatocytes and can facilitate the liver uptake of their substrate drugs. OATP1A2 is expressed on the luminal membrane of small intestinal enterocytes and at the blood-brain barrier, potentially mediating drug transport at these sites. Several clinically used drugs have ...
Source: British Journal of Pharmacology - September 27, 2009 Category: Drugs & Pharmacology Authors: A Kalliokoski, M Niemi Source Type: journals

Exacerbation of chronic idiopathic thrombocytopenic purpura following reactivation of an occult hepatitis BEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of autoimmune thrombocytopenia associated with acute reverse seroconversion of hepatitis B in a patient who was initially hepatitis B virus surface antigen negative and hepatitis B virus surface antibody positive. The search for occult HBV infection before immunosuppressive therapy and monitoring for reactivation is today diagnostic standard and several reports have been presented in literature about HBV reactivation following immunosuppressive therapy. In our patient, reactivation of dormant HBV happened prior to any immunosuppressive therapy. The case we report offers the occasion to emphasize the i...
Source: Medical Oncology - September 22, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Possible montelukast-induced angioedema.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A patient developed angioedema four times during one month of treatment with montelukast. PMID: 19767375 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - September 22, 2009 Category: Drugs & Pharmacology Authors: Sabbagh R, Sheikh-Taha M Tags: Am J Health Syst Pharm Source Type: journals

AMRI files 2 patent-infringement lawsuitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Albany Molecular Research Inc. has filed two new patent-infringement lawsuits with regard to fexofenadine, the active ingredient in Allegra. (SNY) (RDY) (Source: bizjournals.com Health Care:Health Insurance headlines)
Source: bizjournals.com Health Care:Health Insurance headlines - September 15, 2009 Category: American Health Source Type: journals

AMRI files 2 patent-infringement lawsuitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Albany Molecular Research Inc. has filed two new patent-infringement lawsuits with regard to fexofenadine, the active ingredient in Allegra. (SNY) (RDY) (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - September 15, 2009 Category: American Health Source Type: journals

AMRI files 2 patent-infringement lawsuitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Albany Molecular Research Inc. has filed two new patent-infringement lawsuits with regard to fexofenadine, the active ingredient in Allegra. (SNY) (RDY) (Source: bizjournals.com Health Care:Industry Regulation headlines)
Source: bizjournals.com Health Care:Industry Regulation headlines - September 15, 2009 Category: American Health Source Type: journals

AMRI files 2 patent-infringement lawsuitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Albany Molecular Research Inc. has filed two new patent-infringement lawsuits with regard to fexofenadine, the active ingredient in Allegra. (SNY) (RDY) (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - September 15, 2009 Category: Pharmaceuticals Source Type: journals

AMRI files 2 patent-infringement lawsuitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Albany Molecular Research Inc. has filed two new patent-infringement lawsuits with regard to fexofenadine, the active ingredient in Allegra. (SNY) (RDY) (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - September 15, 2009 Category: Biotechnology Source Type: journals

AMRI files 2 patent-infringement lawsuitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Albany Molecular Research Inc. has filed two new patent-infringement lawsuits with regard to fexofenadine, the active ingredient in Allegra. (SNY) (RDY) (Source: bizjournals.com Health Care:Hospitals headlines)
Source: bizjournals.com Health Care:Hospitals headlines - September 15, 2009 Category: Hospital Management Source Type: journals

FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Major Pharmaceuticals]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 14, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 14, 2009 Category: Drugs & Pharmacology Source Type: organizations

Is there a uniform basal endometrial gene expression profile during the implantation window in women who became pregnant in a subsequent ICSI cycle?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS Our data suggest that very few genes, which change their expression level during the WOI, show a quantitative homogeneous expression in endometrially-receptive patients. In conclusion, in this study only six genes showed a homogeneous expression, and are probably involved in embryo implantation mechanisms. (Source: Human Reproduction)
Source: Human Reproduction - September 13, 2009 Category: Reproduction Medicine Authors: Allegra, A., Marino, A., Coffaro, F., Lama, A., Rizza, G., Scaglione, P., Sammartano, F., Santoro, A., Volpes, A. Tags: Reproductive biology Source Type: journals

Leukotriene receptor antagonist in the treatment of childhood allergic rhinitis - a randomized placebo-controlled studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to assess the hypothesis that leukotriene receptor antagonists (LTRAs) would provide additional symptom relief in asthmatic children with persistent AR already taking regular antihistamine. The effects of 16-week treatment of LTRA in addition to fexofenadine (FEX) on persistent AR in asthmatic children were examined.Consecutive children with stable asthma and persistent AR were invited in this randomized, double-blind, placebo-controlled study. After a 2-week run-in period in which subjects were given FEX alone, they were randomly assigned to take LTRA or placebo in addition to FEX for 16 weeks, fol...
Source: Pediatric Pulmonology - September 9, 2009 Category: Respiratory Medicine Authors: Albert M. Li, Victor J. Abdullah, Chui S. Tsen, Chun T. Au, Hugh S. Lam, Hung K. So, Michael H.M. Chan, Alex W.K. Leung, Iris H.S. Chan, Christopher W.K. Lam, Pak C. Ng Source Type: journals

Bioequivalence of fexofenadine tablet formulations assessed in healthy Iranian volunteers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Based on the obtained results the two fexofenadine formulations are considered to be equivalent. PMID: 19728561 [PubMed - in process] (Source: Arzneimittel-Forschung)
Source: Arzneimittel-Forschung - September 6, 2009 Category: Drugs & Pharmacology Authors: Valizadeh H, Barghi L, Jalilian H, Islambulchilar Z, Zakeri-Milani P Tags: Arzneimittelforschung Source Type: journals

FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Major Pharmaceuticals]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 4, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 4, 2009 Category: Drugs & Pharmacology Source Type: organizations

FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Dr. Reddy'S Laboratories Limited]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 1, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 1, 2009 Category: Drugs & Pharmacology Source Type: organizations

Temperature-dependent specific transport of levofloxacin in human intestinal epithelial LS180 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It was reported previously that specific levofloxacin uptake in Caco-2 cells was inhibited by nicotine, enalapril, L-carnitine and fexofenadine. The aim of the present study was to characterize the cellular uptake of levofloxacin using another human intestinal cell line, LS180. Levofloxacin uptake in LS180 cells was temperature-dependent and optimal at neutral pH, but was Na+-independent. The rank order of inhibitory effects of the four compounds on [14C] levofloxacin uptake in LS180 cells was nicotine>enalapril>L-carnitine>fexofenadine, which is consistent with that in Caco-2 cells. The mRNA levels of OATP1A2, 1B1, 1B3 an...
Source: Biopharmaceutics and Drug Disposition - August 31, 2009 Category: Drugs & Pharmacology Authors: Shiro Fukumori, Miki Masago, Kazuya Ishida, Yuichiro Kayano, Masato Taguchi, Yukiya Hashimoto Source Type: journals

Histamine H1 receptor antagonists: Enhancement of ST segment changes (first reports with homochlorcyclizine, fexofenadine, epinastine and dexchlorpheniramine) in a patient with Brugada syndrome: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - August 17, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Long-Term Effects of Panax Ginseng on Disposition of Fexofenadine in Rats in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to explore the pharmacokinetic interaction of Panax Ginseng with fexofenadine in rats. Sprague-Dawley (SD) male rats were divided randomly into four groups: control oral and treatment oral dose groups (n = 6, respectively); control intravenous and treatment intravenous dose groups (n = 5, respectively). A single dose of fexofenadine (10 mg/kg for intravenous group rats and 100 mg/kg for oral dose group rats) was administered after 14 consecutive days of gastric gavage feeding of panax ginseng suspension (150 mg/kg/day) to treatment groups while the same volume of vehicle (1.6% ethanol) was administe...
Source: The American Journal of Chinese Medicine - August 7, 2009 Category: Complementary Medicine Authors: Zhang R, Jie J, Zhou Y, Cao Z, Li W Tags: Am J Chin Med Source Type: journals

Evaluation of the efficacy and safety of olopatadine and fexofenadine compared with placebo in Japanese cedar pollinosis using an environmental exposure unit.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These findings suggest that olopatadine is more effective than placebo and fexofenadine in improving nasal symptoms of Japanese cedar pollinosis. PMID: 19639726 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)
Source: Journal of Investigational Allergology & Clinical Immunology - August 1, 2009 Category: Allergy & Immunology Authors: Enomoto T, Lu HQ, Yin M, Sakoda T, Dake Y, Enomoto K, Ide T, Cheng L Tags: J Investig Allergol Clin Immunol Source Type: journals

Injury Patterns are Different for Older and Younger Patients in Equestrian AccidentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We found different patterns of injuries associated with equestrian accidents for older and younger patients. There were a statistically significant greater percentage of rib and spinal fractures for ages > 50 years. Older horseback riders may benefit from steps to prevent osteoporosis and by using chest protector vests. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - July 31, 2009 Category: Emergency Medicine Authors: J.W. Bilaniuk, A.M. Gage, J.M. Adams, B.K. Siegel, M.I. Cockburn, L.T. DiFazio, J.R. Allegra Tags: Humanities and Medicine Source Type: journals

Rise in Emergency Department Visits of Pediatric Patients for Renal Colic from 1999 to 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We found a marked increase in ED pediatric visits for renal colic over the past decade. This may reflect a real increase in the incidence of renal colic in the pediatric population or an increased use of imaging modalities for abdominal and flank pain. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - July 31, 2009 Category: Emergency Medicine Authors: N. Kairam, J.R. Allegra, B. Eskin Tags: Humanities and Medicine Source Type: journals

A Regional Study of Emergency Department Visits for Acute Exacerbation of Chronic Obstructive Pulmonary Disease, 1996–2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Similar to a previous study, we found no statistically significant change in the rate of visits to the ED for acute exacerbations of COPD or of intubation. However, contrary to that study, and despite availability of newer treatments, hospitalization rates for COPD patients in our area have increased. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - July 31, 2009 Category: Emergency Medicine Authors: O. Faig, J.R. Allegra, B. Eskin Tags: Humanities and Medicine Source Type: journals

Evaluating health-related quality of life, work ability, and disability in pulmonary arterial hypertension: an unmet need.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To our knowledge, there are no specific and validated measures of quality of life (QoL) or degree of disability for pulmonary arterial hypertension (PAH). A review of the literature shows that, with the exception of one recently designed specifically for pulmonary hypertension, QoL questionnaires used in PAH studies are generic measures. These are selected because of shared symptoms that do not necessarily correlate well with functional or physiologic measures and have not been validated for applicability in PAH. In this review, we present the available QoL tools for pulmonary artery hypertension and describe the need ...
Source: Chest - July 31, 2009 Category: Respiratory Medicine Authors: Rubenfire M, Lippo G, Bodini BD, Blasi F, Allegra L, Bossone E Tags: Chest Source Type: journals

The Anne Ford and Allegra Ford Scholarship 2009-2010 National Center for Learning Disabilities, Inc.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deadline for Submission: Postmarked December 31, 2009 The Anne Ford and Allegra Ford Scholarship is a $10,000 award given to two high schoolseniors with identified learning disabilities (LD) who will be pursuing four-yearundergraduate degrees. Eligibility and Selection Criteria The National Center for Learning Disabilities, Inc. (NCLD) is seeking applicants for the Anne Ford and AllegraFord Scholarship, which is available to students of high merit with an identified learning disability (LD). To beeligible for the Anne Ford and Allegra Ford Scholarship, an applicant must:• Have an overall grade point average (GPA) of ...
Source: ScanGrants feed - July 25, 2009 Category: Research Authors: National Center for Learning Disabilities Source Type: funding

Double Posteromedial Portals for Posterior Ankle Arthroscopy in Supine Position.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a two-portal posteromedial hindfoot procedure that allows the surgeon to reach both the posterior joint space and the extraarticular compartment of the hindfoot with the scope and instruments, regardless of diagnosis, with the patient supine. After arthroscopy on the anterior portion of the foot using standard anterior portals, the two posteromedial portals allow endoscopic inspection and management of abnormalities in this region without repositioning the patient and without any remarkable local complication. Level of Evidence: Level IV. See Guidelines for Authors for a complete description of levels of eviden...
Source: Clinical Orthopaedics and Related Research - July 22, 2009 Category: Orthopaedics Authors: Allegra F, Maffulli N Tags: Clin Orthop Relat Res Source Type: journals

Measurement of fexofenadine concentration in micro-sample human plasma by a rapid and sensitive LC-MS/MS employing protein precipitation: application to a clinical pharmacokinetic study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A simple, rapid and sensitive liquid chromatography/positive ion electro-spray tandem mass spectrometry method (LC-MS/MS) was developed and validated for the quantification of fexofenadine with 100 muL human plasma employing glipizide as internal standard (IS). Protein precipitation was used in the sample preparation procedure. Chromatographic separation was achieved on a reversed-phase C(18 )column (5 mum, 100 x 2.1 mm) with methanol : buffer (containing 10 mmol/L ammonium acetate and 0.1% formic acid; 70 : 30, v/v) as mobile phase. The total chromatographic runtime was approximately 3.0 min with retention time for fe...
Source: Biomedical Chromatography : BMC - July 22, 2009 Category: Biomedical Science Authors: Guo D, Zou J, Zhu Y, Lou S, Fan H, Qin Q Tags: Biomed Chromatogr Source Type: journals

[Gastrointestinal Cancer] Initial Safety Report of NSABP C-08: A Randomized Phase III Study of Modified FOLFOX6 With or Without Bevacizumab for the Adjuvant Treatment of Patients With Stage II or III Colon CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Bevacizumab with modified FOLFOX6 is well tolerated in the surgical adjuvant setting in these patients. No significant increase in GI perforation, hemorrhage, arterial or venous thrombotic events, or death with the addition of bevacizumab to modified FOLFOX6 has been observed. Follow-up for potential delayed adverse effects and efficacy is ongoing. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - July 7, 2009 Category: Cancer & Oncology Authors: Allegra, Yothers, O'Connell, Sharif, Colangelo, Lopa, Petrelli, Goldberg, Atkins, Seay, Fehrenbacher, O'Reilly, Chu, Azar, Wolmark Tags: Chemotherapy Gastrointestinal Cancer Source Type: journals

Initial Safety Report of NSABP C-08: A Randomized Phase III Study of Modified FOLFOX6 With or Without Bevacizumab for the Adjuvant Treatment of Patients With Stage II or III Colon Cancer [Gastrointestinal Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Bevacizumab with modified FOLFOX6 is well tolerated in the surgical adjuvant setting in these patients. No significant increase in GI perforation, hemorrhage, arterial or venous thrombotic events, or death with the addition of bevacizumab to modified FOLFOX6 has been observed. Follow-up for potential delayed adverse effects and efficacy is ongoing. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - July 7, 2009 Category: Cancer & Oncology Authors: Allegra, Yothers, O'Connell, Sharif, Colangelo, Lopa, Petrelli, Goldberg, Atkins, Seay, Fehrenbacher, O'Reilly, Chu, Azar, Wolmark Tags: Chemotherapy Gastrointestinal Cancer Source Type: journals

Endothelial progenitor cells: pathogenetic role and therapeutic perspectives.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bone marrow-derived, CD34+ progenitor cells have been shown to promote the repair of damaged tissues, offering promise for the treatment of hereditary and acquired human diseases. These cells in fact differentiate into endothelia, hematopoietic cells and possibly neurons, fibroblasts and muscle. CD34+ and AC133+ progenitor cells may participate in neovascularization by differentiating into endothelial cells. Circulating bone marrow-derived endothelial cells home to sites of neovascularization and stimulate healing of injured tissues but also promote restenosis, tumor growth and inflammatory disease. These cells may thu...
Source: Journal of Nephrology - June 30, 2009 Category: Urology & Nephrology Authors: Allegra A, Coppolino G, Bolignano D, Giacobbe MS, Alonci A, D'Angelo A, Bellomo G, Teti D, Loddo S, Musolino C, Buemi M Tags: J Nephrol Source Type: journals

Pharmacokinetic drug interaction between fexofenadine and fluvastatin mediated by organic anion-transporting polypeptides in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to examine the transporter-mediated drug interaction between fexofenadine and fluvastatin in rats. Compared to the control group given fluvastatin alone, the concurrent use of fexofenadine (10 or 20mg/kg) prior to the oral administration of fluvastatin (5mg/kg) decreased the systemic exposure of fluvastatin by 17-51% in rats. Consequently, the bioavailability of oral fluvastatin was significantly lower (p<0.05) in the presence of fexofenadine compared to that from the control group. Furthermore, the intravenous pharmacokinetics of fluvastatin (2mg/kg) was significantly altered by the pretreatment with f...
Source: European Journal of Pharmaceutical Sciences - June 27, 2009 Category: Drugs & Pharmacology Authors: Qiang F, Lee BJ, Lee W, Han HK Tags: Eur J Pharm Sci Source Type: journals

Regenerative Medicine: does Erythropoietin have a role?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Regenerative Medicine, a recent new medical domain, aims to develop new therapies through the stimulation of natural regenerative processes also in human beings. In this field, Erythropoietin (EPO) represents a significant subject of research. Several studies allow the assertion that EPO, in different concentrations, has protective effects mainly on the central nervous system, cardiovascular system and renal tissue. This action is carried out through one of few regenerative activities of human beings: angiogenesis. This mechanism, which involves endothelial stem cells and VEGF (Vascular Endothelial Growth Factor), has ...
Source: Current Pharmaceutical Design - June 27, 2009 Category: Drugs & Pharmacology Authors: Buemi M, Lacquaniti A, Maricchiolo G, Bolignano D, Campo S, Cernaro V, Sturiale A, Grasso G, Buemi A, Allegra A, Donato V, Genovese L Tags: Curr Pharm Des Source Type: journals

Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Expert Opinion on Drug Metabolism & Toxicology , July 2009, Vol. 5, No. 7, Pages 813-822. (Source: Expert Opinion: Expert Opinion on Drug Metabolism & Toxicology: Table of Contents)
Source: Expert Opinion: Expert Opinion on Drug Metabolism & Toxicology: Table of Contents - June 23, 2009 Category: Drugs & Pharmacology Tags: article Source Type: journals

Suppression of histamine- and allergen-induced skin reactions: comparison of first- and second-generation antihistamines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These results indicate that hydroxyzine is more effective than nsAHs when given as recommended in suppressing histamine-induced or allergic skin reactions. Our results suggest that higher doses of nsAHs than those currently recommended are required for the treatment of skin responses to obtain antihistaminic and antiallergic effects that are equivalent to those of fgAHs. PMID: 19558008 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 31, 2009 Category: Allergy & Immunology Authors: dos Santos RV, Magerl M, Mlynek A, Lima HC Tags: Ann Allergy Asthma Immunol Source Type: journals

JAK2-Positive Latent Essential Thrombocythemia and Splanchnic Vein Thrombosis: The Role of Bone Marrow Biopsy for the Diagnosis of Myeloproliferative Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In these patients with SVT, the detection of JAK2(V617F) mutation is diagnostic for masked MPD as could be documented by bone marrow histopathology. The presence of JAK2(V617F) mutation should be considered per se a prothrombotic state for cerebral, coronary and peripheral microvascular disturbances and for SVT but not for deep vein thrombosis. Anticoagulation is the treatment of choice for all SVT and proper treatment of the MPD is recommended in patients with SVT associated with the JAK2(V617F) mutation. PMID: 19478480 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - May 28, 2009 Category: Hematology Authors: Allegra A, Alonci A, Penna G, D'Angelo A, Rizzotti P, Granata A, Musolino C Tags: Acta Haematol Source Type: journals

Fluticasone furoate nasal spray is more effective than fexofenadine for nighttime symptoms of seasonal allergyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Allergy and Asthma Proceedings)
Source: Allergy and Asthma Proceedings - May 25, 2009 Category: Allergy & Immunology Authors: Andrews, Charles P.Martin, Bruce G.Jacobs, Robert L.Mohar, Dale E.Diaz, Joseph D.Amar, Niran J.Kaiser, Harold B.Vandewalker, Mark L.Bernstein, JonathanToler, William T.Prillaman, Barbara A.Dalal, Anand A.Lee, Laurie A.Philpot, Edward E. Tags: Original Articles Source Type: journals

Why turmeric could be the spice of lifeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eating high-fat curries may not be as bad for us as we thought - at least, not if we lace them with turmeric. Scientists at Boston's Tufts University found that mice fed a high-fat diet that contained curcumin, a component of turmeric, put on less weight. This puts the spice in that magic group of foods with health-giving properties - along with garlic, ginger and fish oils.Like ginger, turmeric is a rhizome, a horizontal stem of a plant that grows underground. Generally speaking, it is prized more for its colour than its flavour: turmeric is the oldest natural food dye in the world, and is now seen in ingredients lists as...
Source: Guardian Unlimited Science - May 20, 2009 Category: Science Authors: Allegra McEvedy Tags: Food & drink Spicy recipes Health wellbeing Life and style The Guardian News Source Type: news

Phase III C-08 Study Of Avastin In Early-Stage Colon Cancer Did Not Meet Primary EndpointEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genentech, Inc. announced that a Phase III study of Avastin ?? (bevacizumab) plus chemotherapy following surgery in patients with early-stage (adjuvant) colon cancer (NSABP C-08) did not meet its primary endpoint of reducing the risk of cancer returning (improvement in disease-free survival). Results are from a planned final analysis of the study. This is the first trial of Avastin in early-stage cancer and results do not affect approved indications in advanced (metastatic) disease. Safety findings were consistent with those presented from this study at the 2008 American Society of Clinical Oncology (ASCO) annual meeting (...
Source: Cancercompass News: Colorectal Cancer - May 8, 2009 Category: Cancer & Oncology Source Type: news

A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In the studies reviewed, desloratadine, fexofenadine, and levocetirizine were effective in relieving the nasal congestion associated with AR compared with placebo. This effect began as early as day 2 and was consistent and progressive throughout treatment. Desloratadine, fexofenadine, and levocetirizine are appropriate options for the treatment of nasal congestion in patients with AR. PMID: 19539095 [PubMed - in process] (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - April 30, 2009 Category: Drugs & Pharmacology Authors: Bachert C Tags: Clin Ther Source Type: journals

Fexofenadine hydrochloride enhances the efficacy of contact immunotherapy for extensive alopecia areata: Retrospective analysis of 121 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To study the effect of fexofenadine on extensive alopecia areata (AA), we evaluated retrospectively 121 patients with AA having alopecia in more than 50% of the scalp and followed them for at least 6 months. Patients were treated by immunotherapy using diphenylcyclopropenone or squaric acid dibutylester with or without oral fexofenadine. The regrowth score was estimated as decrease of Severity of Alopecia Tool (SALT) score. In AA with atopic background (atopic AA), the mean regrowth score of the fexofenadine group was 1.333 (n = 33) and that of the control 0.471 (n = 34). The fexofenadine group showed significantly better ...
Source: The Journal of Dermatology - April 28, 2009 Category: Dermatology Authors: Shigeki INUI, Takeshi NAKAJIMA, Naoyuki TODA, Satoshi ITAMI Tags: Original Articles Source Type: journals

Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Nelfinavir induced methadone clearance by increasing renal clearance, and more so by stereoselectively increasing hepatic metabolism, extraction and clearance. Induction occurred despite 50% inhibition of hepatic CYP3A4/5 activity and more than 75% inhibition of first-pass CYP3A4/5 activity, suggesting little or no role for CYP3A in clinical methadone disposition. Nelfinavir may alter methadone pharmacodynamics, increasing clinical effects. (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - April 20, 2009 Category: Addiction Authors: Evan D. Kharasch, Alysa Walker, Dale Whittington, Christine Hoffer, Pamela Sheffels Bedynek Tags: Full length reports Source Type: journals

[ASCO SPECIAL ARTICLES] American Society of Clinical Oncology Provisional Clinical Opinion: Testing for KRAS Gene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti-Epidermal Growth Factor Receptor Monoclonal Antibody TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose An American Society of Clinical Oncology (ASCO) provisional clinical opinion (PCO), offers timely clinical direction to ASCO's oncologists following publication or presentation of potentially practice-changing data from major studies. This PCO addresses the utility of KRAS gene mutation testing in patients with metastatic colorectal carcinoma to predict response to anti–epidermal growth factor receptor (anti-EGFR) monoclonal antibody (MoAb) therapy with cetuximab or panitumumab (see Note). Clinical Context Recent results from phase II and III clinical trials demonstrate that patients with metastatic colorect...
Source: Journal of Clinical Oncology - April 16, 2009 Category: Cancer & Oncology Authors: Allegra, Jessup, Somerfield, Hamilton, Hammond, Hayes, McAllister, Morton, Schilsky Tags: ASCO SPECIAL ARTICLES Source Type: journals