Allergen-specific immunotherapy for mold allergies
AbstractMolds are ubiquitous in our environment and are considered by the population to be the most important indoor pollutant problem [1]. The current 2023 update to the AWMF mold guideline [1] is intended to allay or channel fears and provide assistance for a sensible diagnosis and treatment decision.The detection of an IgE-mediated allergy implies for allergists Allergen immunotherapy (AIT) as an established treatment option. However, compared to the well-validated AIT with pollen and house dust mites, the decision to use AIT with mold extracts must be weighed more heavily between the benefits and risks.Spores ofAlter...
Source: Allergo Journal International - April 23, 2024 Category: Allergy & Immunology Source Type: research
First report of lymphocyte transformation test positivity in a delayed allergic reaction to ticagrelor
(Source: Allergo Journal International)
Source: Allergo Journal International - April 22, 2024 Category: Allergy & Immunology Source Type: research
Toxicokinetics of aluminium —novel insights in an old adjuvant
ConclusionThe Hethey model is an important step towards prediction of Al exposure in man from various sources. For use in risk assessment of Al exposure from SCIT products further extension of the model is warranted. (Source: Allergo Journal International)
Source: Allergo Journal International - April 17, 2024 Category: Allergy & Immunology Source Type: research
Skin tests, serological IgE detection, basophil test —what is available, useful and helps to clarify a mold allergy?
AbstractThe prevalence of sensitization to molds is low in healthy people, but significant in asthmatics. As it has not yet been possible to establish a cause-and-effect relationship between the presence of mold allergens and the occurrence of allergic symptoms, there is a great deal of uncertainty. The update of the S2k guideline “Medical–clinical diagnostics for indoor mold exposure” should help to objectify the topic. Based on the recomm endations listed there for the diagnosis of suspected IgE-mediated mold allergy, this article presents the possibilities of skin tests, IgE determinations, and other in vitro ...
Source: Allergo Journal International - April 4, 2024 Category: Allergy & Immunology Source Type: research
Aspergillus-associated diseases from an infectious diseases and allergological perspective
AbstractAspergillus-associated diseases are rare and pose challenges for practitioners. Diagnosis is complex and requires rational, targeted, and multidisciplinary collaboration, as well as a high degree of expertise and an individualized approach. For the infectious diseases physician, the focus is on the question of infection or colonization. In severely immunocompromised patients, invasive aspergillosis occurs, which most frequently affects the lungs (IPA) and is characterized by in vasive, destructive growth. This acute clinical picture is associated with a high mortality rate. Chronic pulmonary aspergillosis (CPA) ...
Source: Allergo Journal International - March 22, 2024 Category: Allergy & Immunology Source Type: research
Assessment of a fast challenge test with iodinated contrast media in allergic patients with anaphylaxis
(Source: Allergo Journal International)
Source: Allergo Journal International - March 6, 2024 Category: Allergy & Immunology Source Type: research
Crowd-sourced symptom data in pollen allergy: testing a novel study approach for assessing the efficacy of food supplements
ConclusionThe study design relied on the evaluation of crowd-source symptom data alone by comparing the participants with a baseline. The participant adherence turned out lower than expected; however a trend for reduced symptoms was found and is also supported by the quality-of-life questionnaire. (Source: Allergo Journal International)
Source: Allergo Journal International - January 29, 2024 Category: Allergy & Immunology Source Type: research
Efficacy and safety of the combination nasal spray olopatadine hydrochloride-mometasone furoate in the treatment of allergic rhinitis
ConclusionIn summary, AH and INCS will remain the main groups of active ingredients in the treatment of allergic rhinitis in the future. In combination preparations such as the new combination nasal spray olopatadine hydrochloride-mometasone furoate, they are highly effective and safe, thus opening up new perspectives, especially for patients with moderate and severe allergic rhinitis from the age of 12 years. (Source: Allergo Journal International)
Source: Allergo Journal International - January 22, 2024 Category: Allergy & Immunology Source Type: research
Diagnostic gap due to missing patch test allergens —status quo and possible scenarios for mitigation
SummaryAccording to European Directive 2001/83/EC, test and therapeutic allergens are medicinal products in all Member States of the European Union. This applies equally to prick test and to patch test (PT) allergens (haptens). All test allergens commercially marketed in Germany are finished medicinal products requiring marketing authorization (MA). Currently, 211 PT substances are authorized in Germany, and an additional 59 are in an ongoing MA process and are marketable under a transitional provision until a decision on MA is made. The regulatory guidance (CMDh/399/2019) of the Co-ordination Group for Mutual Recogni...
Source: Allergo Journal International - January 12, 2024 Category: Allergy & Immunology Source Type: research
Tattoo allergy —diagnosis on a circuitous route?
DiscussionDiagnosis of tattoo allergy is challenging. The IVDK Tattoo Study 2.0 enables the identification of metals and pigments in skin samples, the preparation of individual patch test preparations with pigments, and the investigation of specific T lymphocytes in blood samples. In addition, assessment of the clinical relevance can be improved by exposure data and resu lts of laboratory diagnostics. (Source: Allergo Journal International)
Source: Allergo Journal International - December 21, 2023 Category: Allergy & Immunology Source Type: research
Evaluation of systemic inflammation markers in patients with rhinitis
ConclusionWe found that systemic circulation of inflammatory cells was significantly increased in rhinitis with/without allergy compared to the control group. This study showed that not only AR, but also NAR triggers a systemic increase of inflammation which supports the link between rhinitis and comorbid conditions such as asthma. Therefore, effective treatment may be suggested for local inflammation and its systemic manifestations. (Source: Allergo Journal International)
Source: Allergo Journal International - December 18, 2023 Category: Allergy & Immunology Source Type: research
Predictive value of the systemic immune inflammation index and systemic inflammatory response index on omalizumab drug survival in chronic spontaneous urticaria
ConclusionThis study suggests the potential utility of SIRI as a superior predictive indicator for omalizumab’s drug survival in CSU patients compared to SII. Concomitant autoimmune disease or baseline IgE levels did not significantly affect the drug’s effectiveness. (Source: Allergo Journal International)
Source: Allergo Journal International - December 12, 2023 Category: Allergy & Immunology Source Type: research
Successful desensitization to asfotase alfa in hypophosphatasia: a case report and IgE-mediated mechanism confirmation
(Source: Allergo Journal International)
Source: Allergo Journal International - December 8, 2023 Category: Allergy & Immunology Source Type: research
Contact allergy to medical devices
ConclusionWith continued development of medical devices, new contact allergens are introduced. The declaration of their ingredients is necessary for rapid diagnosis and future prevention. (Source: Allergo Journal International)
Source: Allergo Journal International - November 9, 2023 Category: Allergy & Immunology Source Type: research
Orchestration of inflammation in contact allergy by innate immune and cellular stress responses
ConclusionSkin inflammation in ACD is orchestrated by the interplay of the innate immune system and cellular stress responses. (Source: Allergo Journal International)
Source: Allergo Journal International - November 9, 2023 Category: Allergy & Immunology Source Type: research
