Allergy
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Recommendations for assessing Patient-Reported Outcomes and Health-Related quality of life in clinical trials on allergy: a GA2LEN taskforce position paper
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The aim of this Global Allergy and Asthma European Network (GA2LEN) consensus report is to provide recommendations for patient-reported outcomes (PROs) evaluation in clinical trials for allergic diseases, which constitute a global health problem in terms of physical, psychological economic and social impact. During the last 40 years, PROs have gained large consideration and use in the scientific community, to gain a better understanding of patients' subjective assessment with respect to elements concerning their health condition. They include all health-related reports coming from the patient, without involvement or interp...
Source: Allergy - November 21, 2009 Category: Allergy & Immunology Authors: I. Baiardini, P. J. Bousquet, Z. Brzoza, G. W. Canonica, E. Compalati, A. Fiocchi, W. Fokkens, R. G. van Wijk, S. La Grutta, C. Lombardi, M. Maurer, A. M. Pinto, E. Ridolo, G. E. Senna, I. Terreehorst, A. Todo Bom, J. Bousquet, T. Zuberbier, F. Braido Source Type: journals
Matrix metalloproteinases, IL-8 and glutathione in the prognosis of workers exposed to chlorine
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Conclusion: Although no accelerated loss in FEV1 was documented in these workers exposed to chlorine, subjects with a greater fall in FEV1 were more likely to report cough and have higher levels of total glutathione at Vb. (Source: Allergy)
Source: Allergy - November 20, 2009 Category: Allergy & Immunology Authors: K. Maghni, J.-L. Malo, J. L'Archevêque, L. Castellanos, D. Gautrin Source Type: journals
Anaphylaxis to patent blue V: a case series and proposed diagnostic protocol
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Patent blue V is widely used in the identification of sentinel lymph nodes in patients with breast cancer and other malignancies. Individual case reports of allergy to patent blue V have been described in the medical literature since the 1960s. However, there is little data on clinical features and little experience of which allergy tests are appropriate or useful. We gathered all cases of patent blue V allergy that had been seen and diagnosed in the Department of Allergy, Addenbrooke's Hospital over a 3-year period. We collected clinical details of each case including skin test results. For comparison we recruited 12 heal...
Source: Allergy - November 20, 2009 Category: Allergy & Immunology Authors: R. A. Haque, A. Wagner, J. A. Whisken, S. M. Nasser, P. W. Ewan Source Type: journals
State of the art and new horizons in the diagnosis and management of egg allergy
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Egg allergy is one of the most frequent food allergies in children below the age of three. Common symptoms of egg allergy involve frequently the skin as well as the gut and in more severe cases result in anaphylaxis. Non-IgE-mediated symptoms such as in eosinophilic diseases of the gut or egg-induced enterocolitis might also be observed. Sensitization to egg white proteins can be found in young children in absence of clinical symptoms. The diagnosis of egg allergy is based on the history, IgE tests as well as standardized food challenges. Ovomucoid is the major allergen of egg, and recent advances in technology have improv...
Source: Allergy - November 13, 2009 Category: Allergy & Immunology Authors: A. H. Benhamou, J.-C. Caubet, P. A. Eigenmann, A. Nowak-Węgrzyn, C. P. Marcos, M. Reche, A. Urisu Source Type: journals
Is the prevalence of asthma declining? Systematic review of epidemiological studies
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Asthma prevalence has increased very considerably in recent decades such that it is now one of the commonest chronic disorders in the world. Recent evidence from epidemiological studies, however, suggests that the prevalence of asthma may now be declining in many parts of the world, which, if true is important for health service planning and also because this offers the possibility of generating and testing new aetiological hypotheses. Our objective was to determine whether the prevalence of asthma is declining worldwide. We undertook a systematic search of EMBASE, Medline, Web of Science and Google Scholar, for high quali...
Source: Allergy - November 12, 2009 Category: Allergy & Immunology Authors: C. Anandan, U. Nurmatov, O. C. P. van Schayck, A. Sheikh Source Type: journals
The allergy-protective properties of Acinetobacter lwoffii F78 are imparted by its lipopolysaccharide
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Conclusion: We found evidence that the allergy-protecting effects of A. lwoffii F78 are because of the activation of a TH1-polarizing program in human dendritic cells, and that the LPS of A. lwoffii F78 is responsible for these beneficial effects. (Source: Allergy)
Source: Allergy - November 12, 2009 Category: Allergy & Immunology Authors: J. Debarry, A. Hanuszkiewicz, K. Stein, O. Holst, H. Heine Source Type: journals
Protective role of palmitoylethanolamide in contact allergic dermatitis
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Conclusions: We suggest that PEA is an endogenous protective agent against DNFB-induced keratinocyte inflammation and could be considered for therapeutic use against CAD. (Source: Allergy)
Source: Allergy - November 11, 2009 Category: Allergy & Immunology Authors: S. Petrosino, L. Cristino, M. Karsak, E. Gaffal, N. Ueda, T. Tüting, T. Bisogno, D. De Filippis, A. D'Amico, C. Saturnino, P. Orlando, A. Zimmer, T. Iuvone, V. Di Marzo Source Type: journals
The small airways and distal lung compartment in asthma and COPD: a time for reappraisal
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The involvement of small airways in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) has been debated for a long time. However, a proper definition of small airway disease is still lacking, and neither a widely accepted biomarker nor a functional parameter to assess small airway abnormalities and to explore the effect of tested compounds on small airways is available. Aiming towards increased knowledge and consensus on this topic, this perspective paper intends to (i) strengthen awareness among the scientific community on the role of small airways in asthma and COPD; (ii) examine the pros and con...
Source: Allergy - November 11, 2009 Category: Allergy & Immunology Authors: M. Contoli, J. Bousquet, L. M. Fabbri, H. Magnussen, K. F. Rabe, N. M. Siafakas, Q. Hamid, M. Kraft Source Type: journals
Extensive allergic reaction to a new wound closure device (Prineo™)
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(Source: Allergy)
Source: Allergy - November 11, 2009 Category: Allergy & Immunology Authors: K. M. Dunst, J. Auboeck, B. Zahel, B. Raffier, G. M. Huemer Source Type: journals
Atopy susceptibility and chromosome 19q13
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(Source: Allergy)
Source: Allergy - November 11, 2009 Category: Allergy & Immunology Authors: J. W. Holloway, S. J. Barton, I. Sayers Source Type: journals
Effects of nonsedative antihistamines on productivity of patients with pruritic skin diseases
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(Source: Allergy)
Source: Allergy - November 5, 2009 Category: Allergy & Immunology Authors: H. Murota, S. Kitaba, M. Tani, M. Wataya-Kaneda, I. Katayama Source Type: journals
The EuroPrevall-INCO surveys on the prevalence of food allergies in children from China, India and Russia: the study methodology
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Conclusions: This will be the first comparative study of the epidemiology of food allergies in China, India, and Russia using the same standardized methodology. The findings of these surveys will complement the data obtained from Europe and provide insights into the development of food allergy. (Source: Allergy)
Source: Allergy - November 4, 2009 Category: Allergy & Immunology Authors: G. W. K. Wong, P. A. Mahesh, L. Ogorodova, T. F. Leung, O. Fedorova, A. D. Holla, M. Fernandez-Rivas, E. N. Clare Mills, I. Kummeling, R. van Ree, M. Yazdanbakhsh, P. Burney Source Type: journals
Interleukin (IL)-31 induces pro-inflammatory cytokines in human monocytes and macrophages following stimulation with staphylococcal exotoxins
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Conclusion: IL-31 induces pro-inflammatory effects in activated human monocytes and macrophages. This may have implications for cutaneous inflammation in eczema where an over-expression of IL-31 has been described previously. Moreover, our findings provide a new link between staphylococcal colonization and the worsening of inflammation via IL-31. Further therapeutic considerations may include IL-31 as a target in AD. (Source: Allergy)
Source: Allergy - November 4, 2009 Category: Allergy & Immunology Authors: S. Kasraie, M. Niebuhr, T. Werfel Source Type: journals
First case report of anaphylaxis to spirulin: identification of phycocyanin as responsible allergen
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(Source: Allergy)
Source: Allergy - November 4, 2009 Category: Allergy & Immunology Authors: M. Petrus, R. Culerrier, M. Campistron, A. Barre, P. Rougé Source Type: journals
Maculopapular eruption to rivastigmine's transdermal patch application and successful oral desensitization
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(Source: Allergy)
Source: Allergy - November 4, 2009 Category: Allergy & Immunology Authors: M. Makris, S. Koulouris, I. Koti, X. Aggelides, D. Kalogeromitros Source Type: journals
Omalizumab is effective in treating systemic mastocytosis in a nonatopic patient
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(Source: Allergy)
Source: Allergy - November 4, 2009 Category: Allergy & Immunology Authors: J. A. Douglass, K. Carroll, A. Voskamp, P. Bourke, A. Wei, R. E O'Hehir Source Type: journals
Usefulness of basophil activation test in diagnosis of occupational nonasthmatic eosinophilic bronchitis
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(Source: Allergy)
Source: Allergy - November 4, 2009 Category: Allergy & Immunology Authors: G. Pala, P. Pignatti, L. Perfetti, M. Caminati, E. Gentile, G. Moscato Source Type: journals
Asthma-related hospital admissions in an Indian megacity: role of ambient aeroallergens and inorganic pollutants
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(Source: Allergy)
Source: Allergy - November 4, 2009 Category: Allergy & Immunology Authors: D. Ghosh, P. Chakraborty, J. Gupta, A. Biswas, S. Gupta-Bhttacharya Source Type: journals
Hypersensitivity and oral tolerance in the absence of a secretory immune system
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Conclusion: Compensatory regulatory T-cell function becomes critical in pIgR-deficient mice to avoid the potentially catastrophic effects of systemic immune hyperreactivity, presumably resulting from defective secretory antibody-mediated immune exclusion of microbial components. (Source: Allergy)
Source: Allergy - November 3, 2009 Category: Allergy & Immunology Authors: M. R. Karlsson, F.-E. Johansen, H. Kahu, A. Macpherson, P. Brandtzaeg Source Type: journals
Eccrine sweat response in children with asthma
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Conclusion: Our results show that asthma is associated with a higher rate of sweating response to exercise in boys, and anti-inflammatory treatment decreases the amount of sweating. The relationship of eccrine sweating with muscarinic receptor response and methacholine hyperresponsiveness remains to be determined. (Source: Allergy)
Source: Allergy - November 3, 2009 Category: Allergy & Immunology Authors: A. Oflu, O. U. Soyer, A. Tuncer, C. Sackesen, O. Kalayci Source Type: journals
Detection of specific IgE antibodies to cefotiam-HSA conjugate by ELISA in a nurse with occupational anaphylaxis
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(Source: Allergy)
Source: Allergy - November 3, 2009 Category: Allergy & Immunology Authors: J.-E. Kim, S.-H. Kim, G.-S. Choi, Y.-M. Ye, H.-S. Park Source Type: journals
Evaluation of ash pollen sensitization pattern using proteomic approach with individual sera from allergic patients
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Conclusions: No direct correlation was evidenced between IgE profile and the degree of sensitization even though 2 spectrotypes could be distinguished. Our data contribute to a better delineation of ash pollen allergens and patterns of sensitization. (Source: Allergy)
Source: Allergy - November 3, 2009 Category: Allergy & Immunology Authors: P. Poncet, H. Senechal, G. Clement, A. Purohit, J.-P. Sutra, F.-X. Desvaux, J.-M. Wal, G. Pauli, G. Peltre, M.-L. Gougeon Source Type: journals
Efficacy of tranexamic acid in sporadic idiopathic bradykinin angioedema
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(Source: Allergy)
Source: Allergy - November 3, 2009 Category: Allergy & Immunology Authors: A. Du-Thanh, N. Raison-Peyron, C. Drouet, B. Guillot Source Type: journals
Establishing a standardized quality management system for the European Health Network GA2LEN*
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Conclusion: The establishment of a quality management system with joint standards of care and harmonized procedures can be achieved in an international health network and ensures quality of care. (Source: Allergy)
Source: Allergy - November 3, 2009 Category: Allergy & Immunology Authors: L. Heinzerling, G. Burbach, P. van Cauwenberge, P. Papageorgiou, K.-H. Carlsen, K. C. Lødrup Carlsen, T. Zuberbier Source Type: journals
Associations among eczema, asthma, serum immunoglobulin E and depression in adults: a population-based study
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(Source: Allergy)
Source: Allergy - November 3, 2009 Category: Allergy & Immunology Authors: Y.-W. Yang, K.-C. Tseng, Y.-H. Chen, J.-Y. Yang Source Type: journals
Childhood asthma control test (C-ACT) and nasal eosinophil inflammation in asthmatic children
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(Source: Allergy)
Source: Allergy - November 2, 2009 Category: Allergy & Immunology Authors: G. L. Piacentini, D. G. Peroni, E. Bonafiglia, I. Chinellato, A. Bodini, A. L. Boner Source Type: journals
Sustained effect of SQ-standardized grass allergy immunotherapy tablet on rhinoconjunctivitis quality of life
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Conclusion: In subjects inadequately controlled by symptomatic medications, grass AIT provided sustained and clinically relevant improvements in rhinoconjunctivitis quality of life compared to placebo. The effect increased with increasing grass pollen exposure. (Source: Allergy)
Source: Allergy - November 2, 2009 Category: Allergy & Immunology Authors: L. Frølund, S. R. Durham, M. Calderon, W. Emminger, J. S. Andersen, P. Rask, R. Dahl Source Type: journals
Changes in diet and life of children with food allergies after a negative food challenge
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(Source: Allergy)
Source: Allergy - November 2, 2009 Category: Allergy & Immunology Authors: S. Flammarion, C. Santos, D. Romero, C. Thumerelle, A. Deschildre Source Type: journals
Histamine H4 receptor antagonist ameliorates chronic allergic contact dermatitis induced by repeated challenge
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Conclusion: Because chronic allergic contact dermatitis is developed by H4 receptor stimulation, H4 receptor antagonists might represent new candidate drugs for treating chronic allergic contact dermatitis. (Source: Allergy)
Source: Allergy - November 2, 2009 Category: Allergy & Immunology Authors: M. Seike, K. Furuya, M. Omura, K. Hamada-Watanabe, A. Matsushita, H. Ohtsu Source Type: journals
Exhaled NO in asthma: still in touch or definitively out of bounds?
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(Source: Allergy)
Source: Allergy - November 2, 2009 Category: Allergy & Immunology Authors: B. Degano Source Type: journals
A child with anaphylaxis to grapes without reaction to grape seed oil
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(Source: Allergy)
Source: Allergy - November 2, 2009 Category: Allergy & Immunology Authors: F. Cardinale, M. Berardi, I. Chinellato, E. Damiani, E. Nettis Source Type: journals
Food-dependent exercise-induced anaphylaxis in the celery-mugwort-birch-spice syndrome
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(Source: Allergy)
Source: Allergy - October 27, 2009 Category: Allergy & Immunology Authors: C.-H. Baek, Y.-J. Bae, Y. S. Cho, H.-B. Moon, T.-B. Kim Source Type: journals
Food allergen labelling and consumer confusion
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(Source: Allergy)
Source: Allergy - October 26, 2009 Category: Allergy & Immunology Authors: A. Sakellariou, A. Sinaniotis, L. Damianidou, N. G. Papadopoulos, E. Vassilopoulou Source Type: journals
Genetic evidence for a role of IL33 in nasal polyposis
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Conclusion: We provide unprecedented genetic evidence suggesting a role for the IL33 pathway in the pathogenesis of NP. (Source: Allergy)
Source: Allergy - October 26, 2009 Category: Allergy & Immunology Authors: I. D. Buysschaert, V. Grulois, P. Eloy, M. Jorissen, P. Rombaux, B. Bertrand, S. Collet, S. Bobic, S. Vlaminck, P. W. Hellings, D. Lambrechts Source Type: journals
Determining the negative predictive value of provocation tests with beta-lactams
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Conclusion: Although the negative predictive value of drug provocation tests may not be 100%, none of the false negative patients experienced a life-threatening reaction. This should reassure doctors who might hesitate to prescribe beta-lactams, even in patients with negative allergic work-ups. (Source: Allergy)
Source: Allergy - October 26, 2009 Category: Allergy & Immunology Authors: P. Demoly, A. Romano, C. Botelho, L. Bousquet-Rouanet, F. Gaeta, R. Silva, G. Rumi, J. Rodrigues Cernadas, P. J. Bousquet Source Type: journals
Major mite allergen Der f 1 concentration is reduced in buildings with improved energy performance
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Conclusions: Major mite allergen Der f 1 preferentially accumulates in buildings not specifically designed for low energy use, reaching levels at risk for sensitization. We hypothesize that controlled mechanical ventilation present in all audited LEB may favour lower air humidity and hence lower mite growth and allergen concentration, while preserving optimal perceived comfort. (Source: Allergy)
Source: Allergy - October 26, 2009 Category: Allergy & Immunology Authors: F. Spertini, M. Berney, F. Foradini, C.-A. Roulet Source Type: journals
The CONSORT statement checklist in allergen-specific immunotherapy: a GA2LEN paper
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The methodology of randomized clinical trials is essential for the critical assessment and registration of therapeutic interventions. The CONSORT (Consolidated Standards of Reporting Trials) statement was developed to alleviate the problems arising from the inadequate reporting of randomized controlled trials. The present article reflects on the items that we believe should be included in the CONSORT checklist in the context of conducting and reporting trials in allergen-specific immunotherapy. Only randomized, blinded (in particular blinding of patients, health care providers, and outcome assessors), placebo-controlled Ph...
Source: Allergy - October 26, 2009 Category: Allergy & Immunology Authors: P. J. Bousquet, J. Brozek, C. Bachert, T. Bieber, S. Bonini, P. Burney, M. Calderon, G. W. Canonica, E. Compalati, J. P. Daures, L. Delgado, P. Demoly, R. Dahl, S. R. Durham, M. L. Kowalski, H. J. Malling, H. Merk, N. Papadopoulos, G. Passalacqua, Source Type: journals
Comparison of the efficacy and safety of bilastine 20 mg vs levocetirizine 5 mg for the treatment of chronic idiopathic urticaria: a multi-centre, double-blind, randomized, placebo-controlled study
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Conclusions: Bilastine 20 mg is a novel effective and safe treatment option for the management of CU. (Source: Allergy)
Source: Allergy - October 23, 2009 Category: Allergy & Immunology Authors: T. Zuberbier, A. Oanta, E. Bogacka, I. Medina, F. Wesel, P. Uhl, I. Antépara, I. Jáuregui, R. Valiente Source Type: journals
Alternaria sensitization and allergic rhinitis with or without asthma in the French Six Cities study
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Conclusion: In our population-based sample of children, we found a link between Alternaria sensitization and allergic rhinitis, independently of asthma, which is compatible with the mechanisms of deposition of Alternaria in the upper airways. (Source: Allergy)
Source: Allergy - October 22, 2009 Category: Allergy & Immunology Authors: Z. A. Randriamanantany, I. Annesi-Maesano, D. Moreau, C. Raherison, D. Charpin, C. Kopferschmitt, F. Lavaud, A. Taytard, F. De Blay, D. Caillaud Source Type: journals
Sublingual immunotherapy: adherence based on timing and monitoring control visits
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(Source: Allergy)
Source: Allergy - October 21, 2009 Category: Allergy & Immunology Authors: D. Vita, L. Caminiti, P. Ruggeri, G. B. Pajno Source Type: journals
Development, validity and reliability of the food allergy independent measure (FAIM)
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Conclusions: Food allergy independent measures were developed for children, adolescents and adults and were shown to be valid, relevant and reliable. This supports the suitability of the FAIMs for evaluating construct validity. (Source: Allergy)
Source: Allergy - October 20, 2009 Category: Allergy & Immunology Authors: J. L. van der Velde, B. M. J. Flokstra-de Blok, B. J. Vlieg-Boerstra, J. N. G. Oude Elberink, A. DunnGalvin, J. O'B. Hourihane, E. J. Duiverman, A. E. J. Dubois Source Type: journals
Usefulness of basophil activation tests for the diagnosis of IgE-mediated allergy to quinolones
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(Source: Allergy)
Source: Allergy - October 19, 2009 Category: Allergy & Immunology Authors: B. Ben Said, F. Berard, J. Bienvenu, J.-F. Nicolas, A. Rozieres Source Type: journals
Dietary patterns and adult asthma: population-based case–control study
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Conclusions: Overall there were no clear relations between dietary patterns and adult asthma; associations in nonsupplement users and whites require confirmation. The finding for chronic bronchitis was unexpected and also requires replication. (Source: Allergy)
Source: Allergy - October 19, 2009 Category: Allergy & Immunology Authors: I. Bakolis, R. Hooper, R. L. Thompson, S. O. Shaheen Source Type: journals
Allergen provocation increases TH2-cytokines and FOXP3 expression in the asthmatic lung
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Conclusion: Despite an increase in CD4+CD25bright cells expressing high levels of FOXP3 in response to bronchial allergen provocation, asthmatic patients exhibit enhanced levels of Th2 cytokines in the lung, which may indicate an inability among infiltrating cells to suppress Th2 responses. (Source: Allergy)
Source: Allergy - October 19, 2009 Category: Allergy & Immunology Authors: S. Thunberg, G. Gafvelin, M. Nord, R. Grönneberg, J. Grunewald, A. Eklund, M. van Hage Source Type: journals
A case–control study of vitamin D status and asthma in adults
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(Source: Allergy)
Source: Allergy - October 19, 2009 Category: Allergy & Immunology Authors: G. Devereux, A. Wilson, A. Avenell, G. McNeill, W. D. Fraser Source Type: journals
Multicentre trial evaluating alveolar NO fraction as a marker of asthma control and severity
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Conclusion: Alveolar and exhaled NO fractions are not indexes of control or severity in asthmatic children and adults under treatment. (Source: Allergy)
Source: Allergy - October 19, 2009 Category: Allergy & Immunology Authors: B. Mahut, L. Trinquart, M. Le Bourgeois, M.-H. Becquemin, N. Beydon, F. Aubourg, M. Jala, B. Bidaud-Chevalier, A.-T. Dinh-Xuan, O. Randrianarivelo, A. Denjean, J. de Blic, C. Delclaux Source Type: journals
Coagulation/fibrinolysis and inflammation markers are associated with disease activity in patients with chronic urticaria
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Conclusions: The measurement of plasma FDP, d-dimer and serum CRP may be useful for the assessment of disease activity of CU. (Source: Allergy)
Source: Allergy - October 19, 2009 Category: Allergy & Immunology Authors: S. Takahagi, S. Mihara, K. Iwamoto, S. Morioke, T. Okabe, Y. Kameyoshi, M. Hide Source Type: journals
Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure
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Conclusions: FLG mutations are associated both with atopic and nonatopic eczema starting in the first year of life. FLG mutations combined with eczema in the first year of life are associated with a later development of asthma and hay fever, a clear example of the atopic march. We confirm that cat exposure enhances the effect of a FLG mutation on the development of eczema and sensitization. (Source: Allergy)
Source: Allergy - October 14, 2009 Category: Allergy & Immunology Authors: M. L. A. Schuttelaar, M. Kerkhof, M. F. Jonkman, G. H. Koppelman, B. Brunekreef, J. C. de Jongste, A. Wijga, W. H. I. McLean, D. S. Postma Source Type: journals
Methylprednisolone-induced anaphylaxis: diagnosis by skin test and basophil activation test
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(Source: Allergy)
Source: Allergy - October 14, 2009 Category: Allergy & Immunology Authors: B. Ben Said, V. Leray, J. F. Nicolas, A. Rozieres, F. Berard Source Type: journals
Anaphylaxis to argan oil
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(Source: Allergy)
Source: Allergy - October 14, 2009 Category: Allergy & Immunology Authors: C. Astier, Y. El Alaoui Benchad, D.-A. Moneret-Vautrin, B. E. Bihain, G. Kanny Source Type: journals
