AllopurinolThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you your search results in order of date.

Pages: 1 2 3 4 5 6 7 8 9

424 records returned

Update on gout and hyperuricemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There have been recent advances in the understanding of underlying mechanisms and treatment of gout and chronic hyperuricemia, making this an important time to review the current state of the disease. The goal of this article is to provide a practical review of the current standard of care as well as discuss some new developments in the management. There is an increasing prevalence of gout and hyperuricemia worldwide. Gout confers a significant individual and societal burden and is often under-treated. Appropriate diagnosis and treatment of acute gout should be followed by aggressive and goal-oriented treatment of hyperuri...
Source: International Journal of Clinical Practice - November 11, 2009 Category: Internal Medicine Authors: J. F. Baker, H. Ralph Schumacher Source Type: journals

ASN: Febuxostat Works in Gout Patients with Renal Impairment (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAN DIEGO (MedPage Today) -- In patients with gout and preexisting mild to moderate renal impairment, febuxostat (Uloric) is more effective and as safe as allopurinol, the gold standard gout treatment, researchers found. (Source: MedPage Today Meeting Coverage)
Source: MedPage Today Meeting Coverage - November 2, 2009 Category: Journals (General) Source Type: info

CorrectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The article “Febuxostat, Allopurinol Jockey for Role in Gout” (October 2009, p. 20) misrepresented the views of Dr. Naomi Schlesinger. She does not think that all gout patients with hyperuricemia and renal disease should be on febuxostat. She does not advise avoiding allopurinol altogether in patients with renal failure. We regret the error. (Source: Rheumatology News)
Source: Rheumatology News - November 1, 2009 Category: Rheumatology Tags: News Source Type: journals

Allopurinol's Top Dose May Need To Be IncreasedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PHILADELPHIA — A new study confirms what rheumatologists already know: Some patients with gout fail to achieve adequate reductions in serum urate levels with recommended levels of allopurinol. (Source: Rheumatology News)
Source: Rheumatology News - November 1, 2009 Category: Rheumatology Authors: Amy Rothman Schonfeld Tags: News Source Type: journals

Allopurinol for Angina Improves Exercise TimeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BARCELONA — Allopurinol treatment for 6 weeks significantly improved symptoms of chronic, stable angina in a randomized, placebo-controlled, crossover study of 60 patients. Allopurinol administered at labeled dosages produced three significant improvements during an exercise treadmill test, which were the study's primary end points: increased total exercise time, increased time to ST-segment depression, and increased time to angina, Dr. Awsan Noman said at the annual congress of the European Society of Cardiology. (Source: Cardiology News)
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: MITCHEL L. ZOLER Tags: Cad & Atherosclerosis Source Type: news

Allopurinol: Drug-induced hypersensitivity syndrome in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 31, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Maternal Allopurinol During Fetal Hypoxia Lowers Cord Blood Levels of the Brain Injury Marker S-100B.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 705DOI: 10.1097/01.ogx.0000361378.74763.4bAuthors: Torrance, Helen L.; Benders, Manon J.; Derks, Jan B.; Rademaker, Carin M. A.; Bos, Arie F.; Van Den Berg, Paul; Longini, Mariangela; Buonocore, Giuseppe; Venegas, Maria Elena; Baquero, Hernando; Visser, Gerard H. A.; Van Bel, Frank (Source: Obstetrical & Gynecological Survey)
Source: Obstetrical & Gynecological Survey - October 30, 2009 Category: OBGYN Tags: Abstract HTML PDF (799 K) Source Type: journals

Vasomotor dysfunction in the thoracic aorta of Marfan syndrome is associated with accumulation of oxidative stress.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have described that the progression of thoracic aortic aneurysm in Marfan syndrome is accompanied with aortic vascular dysfunction. In the present study, w hypothesized that the impaired contractile function and endothelial-dependent relaxation could be resulted from oxidative stress in the thoracic aorta. Adrenergic contraction and cholinergic relaxation of thoracic aortae from mice (n=40; age=3, 6, 9months) heterozygous for FBN1 allele (Fbn1C(1039G/+)), a well-defined model of Marfan syndrome, were compared with those from control (n=40). The aortic 8-isoprostane level, an oxidative stress marker, was 32-50% great...
Source: Vascular Pharmacology - October 29, 2009 Category: Drugs & Pharmacology Authors: Yang HH, van Breemen C, Chung AW Tags: Vascul Pharmacol Source Type: journals

ACR: Allopurinol Sensitivity More Likely in Patients with Renal Problems (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PHILADELPHIA (MedPage Today) -- Hypersensitivity to the anti-uricemic drug allopurinol, often leading to acute kidney failure, is up to three times as common in patients who already suffer renal impairment, according to research presented here. (Source: MedPage Today Meeting Coverage)
Source: MedPage Today Meeting Coverage - October 28, 2009 Category: Journals (General) Source Type: info

Higher doses of allopurinol may benefit gout patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New research suggests that people with gout may benefit from taking more than the recommended dose of allopurinol, a drug that helps to lower the level of urate in the blood. (Source: Arthritis Research Campaign)
Source: Arthritis Research Campaign - October 26, 2009 Category: Rheumatology Authors: Arthritis Research Campaign (mailto:info at arc.org.uk) Source Type: news

Health News of the DayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day:Meta-analysis finds 6-13% increased risk of diabetes in those who received statin therapy http://bit.ly/3iX7vd -- Although statin therapy greatly lowers vascular risk, relationship of statins to incident diabetes remains uncertain http://bit.ly/3BFQv5 -- "Statin-Induced Diabetes" - the headline of this editorial may be a bit premature considering the available evidence http://bit.ly/15L33KDiabetes drug liraglutide contains a...
Source: Clinical Cases and Images - October 24, 2009 Category: Journals (General) Tags: Health News of the Day Source Type: info

ACR: Pump Up the Allopurinol to Prevent Gout (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PHILADELPHIA (MedPage Today) -- Going beyond the recommended dosing of allopurinol (Zyloprim) to treat patients with gout may help prevent recurrence safely, researchers contended here. (Source: MedPage Today Meeting Coverage)
Source: MedPage Today Meeting Coverage - October 23, 2009 Category: Journals (General) Source Type: info

A Case of Gingival Ulcer Thought to Be Caused by AllopurinolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Allopurinol is an oral therapeutic drug for hyperuricemia that has been used widely in clinical practice since 1963. Dermatitis develops at a frequency of 2% as an adverse drug reaction, and fever, headache, impaired glucose tolerance, and gastrointestinal disorder also occur in about 10%. A severe adverse drug reaction, allopurinol hypersensitivity syndrome, in which skin disorders, such as Stevens-Johnson syndrome and toxic epidermal necrosis, are accompanied by renal failure, hepatitis, vasculitis, and eosinophilia rarely occurs. Several cases regarding oral mucosal ulcer have been reported, but there has been no detail...
Source: Journal of Oral and Maxillofacial Surgery - October 20, 2009 Category: ENT & OMF Authors: Chu Sato, Joji Nomura, Yoshihiko Matsumura, Yoshihiro Watanabe, Kasumi Shimizu, Toshiro Tagawa Tags: Case Reports Source Type: journals

Zyloric 100mg, 300mg tablets (allopurinol) - Revised SPCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC to include updates to section 4.4 Special warnings and precautions for use and 4.8 Undesirable effects. Inclusion of Stevens-Johnson syndrome and toxic epidermal necrolysis. (Source: NeLM - SPC Changes)
Source: NeLM - SPC Changes - October 19, 2009 Category: Drugs & Pharmacology Source Type: organizations

Allopurinol: DRESS syndrome in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 19, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

[Crystal-induced activation of the inflammasome: gout and pseudogout.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Crystals in tissues lead the innate immune system to the same kind of acute response seen with pathogens. Via activation of the inflammasome, interleukin-1 (IL-1) is released, which upregulates mediators such as cyclooxygenase, tumor necrosis factor, and IL-8 and induces an acute granulocytic inflammation. Therefore, in addition to nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, and colchicine, IL-1 blockers appear to be effective. Large clinical trials have already been initiated. Such an approach could constitute a valuable alternative for patients with contraindications or insufficient response to NSAIDs. A...
Source: Zeitschrift fur Rheumatologie - October 16, 2009 Category: Rheumatology Authors: Winzer M, Tausche AK, Aringer M Tags: Z Rheumatol Source Type: journals

Allopurinol Aids Patients With Stable AnginaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BARCELONA — Allopurinol treatment for 6 weeks significantly improved symptoms of chronic, stable angina in a randomized, placebo-controlled, crossover study of 60 patients. Allopurinol administered at labeled dosages produced three significant improvements during an exercise treadmill test, which were the study's primary end points: increased total exercise time, increased time to ST segment depression, and increased time to angina, Dr. Awsan Noman said at the annual congress of the European Society of Cardiology. (Source: Family Practice News)
Source: Family Practice News - October 15, 2009 Category: Primary Care Authors: MITCHEL L. ZOLER Tags: Cardiovascular Medicine Source Type: news

Effect of allopurinol versus urate oxidase on methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Allopurinol and urate oxidase are both effective in preventing or treating hyperuricemia during remission induction therapy for lymphoid malignancies, but to the authors' knowledge, their effects on concomitant anticancer drug therapy have not been compared.The authors compared plasma methotrexate pharmacokinetics in pediatric patients with newly diagnosed acute lymphoblastic leukemia who received concomitant allopurinol (n = 20) versus those treated with nonrecombinant or recombinant urate oxidase (n = 96) during high-dose methotrexate administration before conventional remission induction therapy.The minimum plasma conce...
Source: Cancer - October 14, 2009 Category: Cancer & Oncology Authors: Kristine R. Crews, Yinmei Zhou, Jennifer L. Pauley, Scott C. Howard, Sima Jeha, Mary V. Relling, Ching-Hon Pui Source Type: journals

Drug dosage protocol for calcium oxalate stone.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to identify the most effective directed medical treatment of urinary stones. The drug dose adjustment was based on clinical, radiological, biochemical, and microscopic parameters. 444 patients with proved calcium oxalate stone disease who were getting a combination of allopurinol and pyridoxine for a minimum period of 36 months were enrolled in this prospective study. The dosage schedule of these patients was recorded. Dosage adjustment was made depending upon the various clinical, biochemical, microscopic, and radiological changes during the study period. The dosage schedules were in six cat...
Source: Urological Research - October 13, 2009 Category: Urology & Nephrology Authors: Marickar YM, Salim A Tags: Urol Res Source Type: journals

Drug dosage protocol for calcium oxalate stoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study is to identify the most effective directed medical treatment of urinary stones. The drug dose adjustment was based on clinical, radiological, biochemical, and microscopic parameters. 444 patients with proved calcium oxalate stone disease who were getting a combination of allopurinol and pyridoxine for a minimum period of 36 months were enrolled in this prospective study. The dosage schedule of these patients was recorded. Dosage adjustment was made depending upon the various clinical, biochemical, microscopic, and radiological changes during the study period. The dosage schedules were ...
Source: Urological Research - October 13, 2009 Category: Urology & Nephrology Tags: Urological Research Source Type: journals

Pharmacological interventions v no pharmacological intervention for ischaemia reperfusion injury in liver resection performed under vascular controlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Published October 2009 Summary: Elective liver surgery undertaken for a variety of reasons may require occlusion of the blood supply to the liver in order to reduce bleeding from the cut liver surface. This temporary blood supply interruption can cause liver damage for a variety of reasons. In experimental studies many drugs have shown some promise in decreasing liver damage caused by the occluded blood supply. We identified a total of 15 randomised trials evaluating 11 different pharmacological interventions (methylprednisolone, multivitamin antioxidant infusion, vitamin E infusion, amrinone, prostaglandin E1, pentoxifyll...
Source: Gastroenterology and Liver Diseases Specialist Library - Liver - October 13, 2009 Category: Gastroenterology Source Type: organizations

Metabolism of ethanol to acetaldehyde and increased susceptibility to oxidative stress could play a role in the ovarian tissue cell injury promoted by alcohol drinkingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we analyzed the possibility that part of those effects were mediated through alterations of ovarian function related to ethanol oxidation to acetaldehyde occurring in situ. Biotransformation in the rat ovary cytosolic fraction was partially inhibited by allopurinol, suggesting the participation of xanthine oxidoreductase in the process. Microsomal pathway was of enzymatic nature, requiring nicotinamide adenine dinucleotide phosphate-oxidase (NADPH), sensitive to oxygen and significantly inhibited by sodium diethyldithiocarbamate, 4-methylpyrazole and diphenyleneiodonium. Aldehyde dehydrogenase activity was d...
Source: Toxicology and Industrial Health current issue - October 13, 2009 Category: Toxicology Authors: Faut, M., Rodriguez de Castro, C., Bietto, F. M, Castro, J. A, Castro, G. D Tags: Articles Source Type: journals

Seasonality and trends in the incidence and prevalence of gout in England and Wales 1994-2007 [Clinical and epidemiological research]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The incidence of gout is seasonal. This has implications for the management of patients who currently have gout, and for those who are at risk of future attacks. The decreasing trend in the incidence of acute attacks suggests that patient management is improving. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - October 12, 2009 Category: Rheumatology Authors: Elliot, A J, Cross, K W, Fleming, D M Tags: Genetics, Degenerative joint disease, Musculoskeletal syndromes Clinical and epidemiological research Source Type: journals

Seasonality and trends in the incidence and prevalence of gout in England and Wales 1994-2007Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The incidence of gout is seasonal. This has implications for the management of patients who currently have gout, and for those who are at risk of future attacks. The decreasing trend in the incidence of acute attacks suggests that patient management is improving. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - October 12, 2009 Category: Rheumatology Authors: Elliot, A J, Cross, K W, Fleming, D M Tags: Genetics, Degenerative joint disease, Musculoskeletal syndromes Clinical and epidemiological research Source Type: journals

Meta-analysis of prophylactic allopurinol use in post-endoscopic retrograde cholangiopancreatography pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A structured abstract written by CRD reviewers. The abstract was published on 7 October 2009 from an original article published in 2008. (Source: Gastroenterology and Liver Diseases Specialist Library - Pancreas)
Source: Gastroenterology and Liver Diseases Specialist Library - Pancreas - October 12, 2009 Category: Gastroenterology Source Type: organizations

Meta-analysis of prophylactic allopurinol use in post-endoscopic retrograde cholangiopancreatography pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A structured abstract written by CRD reviewers. The abstract was published on 7 October 2009 from an original article published in 2008. (Source: Gastroenterology and Liver Diseases Specialist Library - Diagnostic procedures)
Source: Gastroenterology and Liver Diseases Specialist Library - Diagnostic procedures - October 12, 2009 Category: Gastroenterology Source Type: organizations

Allopurinol-Induced DRESS Syndrome in an Adolescent PatientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A 16-year-old male patient, with a history of essential hypertension enrolled in an experimental drug protocol using allopurinol, presented to our emergency department with a 10-day history of fever. Initial laboratory evaluation revealed leukocytosis, eosinophilia, and transaminitis. After extensive work-up and exclusion of infectious and oncologic etiologies, the diagnosis of allopurinol-induced drug reaction and eosinophilia with systemic symptoms syndrome was carried out. The patient responded to administration of IV methylprednisolone, with complete resolution of symptoms and improvement of laboratory abnorm...
Source: Pediatric Dermatology - October 4, 2009 Category: Dermatology Authors: Ashvin K. Dewan, Ricardo A. Quinonez Source Type: journals

Febuxostat, Allopurinol Jockey for Role in GoutEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Estimates of how many patients with gout should be treated with febuxostat range from just 5% to millions, according to experts interviewed for this article. What is not debatable 6 months after febuxostat went on the U.S. market is that it's clearly the second-line agent behind allopurinol, those same experts agreed. Allopurinol retains the top spot because of its substantially larger and longer track record and its dramatically lower cost. (Source: Family Practice News)
Source: Family Practice News - September 30, 2009 Category: Primary Care Authors: MITCHEL L. ZOLER Tags: Musculoskeletal Disorders Source Type: news

Febuxostat, Allopurinol Jockey for Role in Gout: Allopurinol remains the first-line agent in gout treatment, despite issues of kidney clearance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Estimates of how many patients with gout should be treated with febuxostat range from just 5% to millions, according to experts interviewed for this article. What is not debatable 6 months after febuxostat went on the U.S. market is that it's clearly the second-line agent behind allopurinol, the experts agreed. Allopurinol retains the top spot because of its substantially larger and longer track record and its dramatically lower cost. (Source: Rheumatology News)
Source: Rheumatology News - September 30, 2009 Category: Rheumatology Authors: MITCHEL L. ZOLER Source Type: journals

The effects of lowering uric acid levels using allopurinol on markers of metabolic syndrome in end-stage renal disease patients: a pilot study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Novel findings of our study suggest that lowering uric acid in ESRD patients may help to reduce the risk of cardiovascular disease in this population. It should be noted than an increase in triglycerides may mitigate the reduction in risk. PMID: 19819789 [PubMed - in process] (Source: Anadolu Kardiyol Der...)
Source: Anadolu Kardiyol Der... - September 30, 2009 Category: Cardiology Authors: Shelmadine B, Bowden RG, Wilson RL, Beavers D, Hartman J Tags: Anadolu Kardiyol Derg Source Type: journals

Immunotherapy with the saponin enriched-Leishmune((R)) vaccine versus immunochemotherapy in dogs with natural canine visceral leishmaniasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Leishmune((R)), the first licensed vaccine for prophylaxis against canine visceral leishmaniasis (CVL) and is also immunotherapeutic when used with double saponin adjuvant concentration. The Leishmune((R)) therapeutic vaccine was assessed for immunotherapy (IT) in 31 infected dogs and for immunochemotherapy (ICT) in combination with allopurinol or amphotericinB/allopurinol, in 35 dogs. Compared to infected untreated control dogs, at month 3, both treatments increased the proportion of dogs showing intradermal response to Leishmania antigen to a similar extent (from 8 to 67%, in the IT and to 76%, in the ICT groups), an...
Source: Vaccine - September 29, 2009 Category: Allergy & Immunology Authors: Borja-Cabrera GP, Santos FN, Santos FB, Trivellato FA, Kawasaki JK, Costa AC, Castro T, Nogueira FS, Moreira MA, Luvizotto MC, Palatnik M, Palatnik-de-Sousa CB Tags: Vaccine Source Type: journals

Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fructose consumption has been recently related to an epidemic of metabolic syndrome, and hyperuricemia plays a pathogenic role in fructose-induced metabolic syndrome. Fructose-fed rats showed hyperuricemia and renal dysfunction with reductions of the urinary uric acid/creatinine ratio and fractional excretion of uric acid (FEur), as well as other features of metabolic syndrome. Lowering serum uric acid levels with allopurinol, rutin, and quercetin increased the urinary uric acid/creatinine ratio and FEur and attenuated other fructose-induced metabolic abnormalities in rats, demonstrating that hyperuricemia contributed to t...
Source: AJP: Renal Physiology - September 27, 2009 Category: Urology & Nephrology Authors: Hu, Q.-H., Wang, C., Li, J.-M., Zhang, D.-M., Kong, L.-D. Tags: ARTICLES Source Type: journals

Antioxidant therapy in the management of acute, chronic and post-ERCP pancreatitis: a systematic review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the present data do not support a benefit of antioxidant therapy alone or in combination with conventional therapy in the management of AP, CP or PEP. Further double blind, randomized, placebo-controlled clinical trials with large sample size need to be conducted. PMID: 19777606 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 26, 2009 Category: Gastroenterology Authors: Mohseni Salehi Monfared SS, Vahidi H, Abdolghaffari AH, Nikfar S, Abdollahi M Tags: World J Gastroenterol Source Type: journals

Gout Drug May Lower Blood PressureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A study shows allopurinol helps fight hypertension for people on a high-sugar diet. WebMD Health News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 24, 2009 Category: Consumer Health News Tags: Cardiology Source Type: news

AHA/HBP: Fructose Linked to Hypertension, Metabolic EffectEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In adult men, the metabolic effects of high fructose intake may be mitigated by the uric acid-lowering effects of allopurinol, according to research presented this week at the American Heart Association's 63rd High Blood Pressure Research Conference, held from Sept. 23 to 26 in Chicago. (Source: Modern Medicine)
Source: Modern Medicine - September 23, 2009 Category: Journals (General) Source Type: info

Allopurinol Lowers Fructose-Triggered Hypertension (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A diet high in fructose can increase uric acid levels, but allopurinol may help lower the resulting high blood pressure, researchers say. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - September 23, 2009 Category: Cardiology Source Type: news

Allopurinol/imatinib: Stevens-Johnson syndrome in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 21, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

What Are Some Common Presentations for Inborn Errors of Metabolism?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion Each inborn errors of metabolism (IEM) by itself is often rare but taken as a whole, IEM are common. IEM often present in the newborn or infancy periods but can present at any time including adulthood. The genetic defect often causes a problem in the catabolism or synthesis of carbohydrates, fats, or proteins. The defect causes a blockage in the metabolic pathway with intermediate molecules accumulating (often toxic accumulations) before the blockage and metabolites after the blockage being scarce (inadequate energy production/utilization). Diet and stresses including surgery, trauma, and illness often can trigg...
Source: PediatricEducation.org - September 14, 2009 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: info

Secreted phospholipase A2-IIA modulates key regulators of proliferation on astrocytoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we used human astrocytoma 1321N1 cells to investigate the key molecules mediating sPLA2-IIA-induced cell proliferation. We found that sPLA2-IIA promoted reactive oxygen species (ROS) accumulation, which was abrogated in the presence of allopurinol and DPI, but not by rotenone, discarding mitochondria as a ROS source. In addition, sPLA2-IIA triggered Ras and Raf-1 activation, with kinetics that paralleled ERK phosphorylation, and co-immunoprecipitation assays indicated an association between Ras, Raf-1 and ERK. Additionally, Akt, p70 ribosomal protein S6 kinase, and S6 ribosomal protein were also phosphorylat...
Source: Journal of Neurochemistry - September 7, 2009 Category: Neurology Authors: Rubén Martín, Marita Hernández, Elvira Ibeas, Lucia Fuentes, Veronica Salicio, Mercedes Arnés, María Luisa Nieto Source Type: journals

Preservation of cardiac contractility after long-term therapy with oxypurinol in post-ischemic heart failure in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we tested the sustainability of this enhanced contraction associated with decreased oxidative damage over an extended time. Mice were divided into three groups: sham-operated control, myocardial infarction-heart failure (MI-HF), and oxypurinol-treated heart failure (Oxy-HF). After 9 -11months, echocardiography showed that mice treated with oxypurinol (1mM in drinking water) had significantly higher left ventricle fractional contraction and fractional wall thickening during systole than did mice in the MI-HF group (left ventricle fractional contraction: 28.4+/-2.2% vs. 19.9+/-2.3%, P<0.05; left ventricle f...
Source: European Journal of Pharmacology - September 4, 2009 Category: Drugs & Pharmacology Authors: Tan Z, Dai T, Zhong X, Tian Y, Leppo MK, Gao WD Tags: Eur J Pharmacol Source Type: journals

Allopurinol: a necessary evil.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19787189 [PubMed - in process] (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - August 31, 2009 Category: Journals (General) Authors: Lim AY, Teng GG Tags: Singapore Med J Source Type: journals

Antral ulcers induced by alendronate, a nitrogen-containing biphophonate, in rat stomachs - prophylactic effect of rebamipide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We demonstrated the development of antral ulcers induced in rats by alendronate and investigated the pathogenic factors involved in this model. Animals fasted for 18 h were given alendronate p.o., and then re-fed normally and killed on various days up to 7 days later. Alendronate caused non-hemorrhagic damage in both the corpus and antrum of fasted rats, but after refeeding for 3 days the lesions in the corpus healed completely, while those in the antrum developed into large ulcers with increased vascular permeability. The development of antral ulcers was accompanied by an increase in MPO activity and lipid peroxidatio...
Source: J Physiol Pharmacol - August 31, 2009 Category: Drugs & Pharmacology Authors: Ohashi Y, Aihara E, Takasuka H, Takahashi K, Takeuchi K Tags: J Physiol Pharmacol Source Type: journals

Allopurinol: Toxic epidermal necrolysis in a child: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - August 24, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Allopurinol/paclitaxel: First report of gout with paclitaxel and first report of an interaction between allopurinol and paclitaxel?: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - August 24, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Combination of Captopril and Allopurinol Retards Fructose-Induced Metabolic Syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A high fructose diet can induce metabolic syndrome even in the setting of caloric restriction. Captopril and allopurinol synergistically reduce features of the metabolic syndrome, especially hypertension, insulin resistance and dyslipidemia. Combination allopurinol and ACE inhibitor therapy might provide a superior means to prevent diabetes and cardiovascular disease. PMID: 19696478 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 20, 2009 Category: Urology & Nephrology Authors: Roncal CA, Reungjui S, Sánchez-Lozada LG, Mu W, Sautin YY, Nakagawa T, Johnson RJ Tags: Am J Nephrol Source Type: journals

Exercise Activation of Muscle Peroxisome Proliferator-activated Receptor gamma Co-activator 1 alpha Signaling is Redox Sensitive.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of the present study were (1) to investigate whether PGC-1alpha pathway could be activated by a single bout of anaerobic exercise in rats, wherein a main portion of ROS was generated via the cytosolic xanthine oxidase (XO); and (2) to examine whether allopurinol (ALP), a specific XO inhibitor, would attenuate PGC-1alpha expression and signaling due to decreased ROS generation. Female Sprague-Dawley rats were randomly divided into three groups: (1) subjected to sprinting on treadmill at 35 m/min, 15% grade for 3 min followed by 3 min slow running at 15 m/min, 0% grade, repeated until exhaustion (88 +/-4 min; ...
Source: Free Radical Biology and Medicine - August 13, 2009 Category: Biology Authors: Kang C, O'Moore KM, Dickman JR, Ji LL Tags: Free Radic Biol Med Source Type: journals

Meta-analysis - allopurinol in the prevention of postendoscopic retrograde cholangiopancreatography pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A structured abstract written by CRD reviewers. The abstract was published on 15 July 2009 from an original article published in 2008. (Source: Gastroenterology and Liver Diseases Specialist Library - Diagnostic procedures)
Source: Gastroenterology and Liver Diseases Specialist Library - Diagnostic procedures - August 11, 2009 Category: Gastroenterology Source Type: organizations

Meta-analysis - allopurinol in the prevention of postendoscopic retrograde cholangiopancreatography pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A structured abstract written by CRD reviewers. The abstract was published on 15 July 2009 from an original article published in 2008. (Source: Gastroenterology and Liver Diseases Specialist Library - Pancreas)
Source: Gastroenterology and Liver Diseases Specialist Library - Pancreas - August 11, 2009 Category: Gastroenterology Source Type: organizations