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Drug effect on EEG connectivity assessed by linear and nonlinear couplingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Quantitative analysis of human electroencephalogram (EEG) is a valuable method for evaluating psychopharmacological agents. Although the effects of different drug classes on EEG spectra are already known, interactions between brain locations remain unclear. In this work, cross mutual information function and appropriate surrogate data were applied to assess linear and nonlinear couplings between EEG signals. The main goal was to evaluate the pharmacological effects of alprazolam on brain connectivity during wakefulness in healthy volunteers using a cross-over, placebo-controlled design. Eighty-five pairs of EEG leads were ...
Source: Human Brain Mapping - November 6, 2009 Category: Neurology Authors: Joan F. Alonso, Miguel A. Mañanas, Sergio Romero, Dirk Hoyer, Jordi Riba, Manel J. Barbanoj Source Type: journals

Early onset anxiolytic efficacy after a single dose of pregabalin: double-blind, placebo- and active-comparator controlled evaluation using a dental anxiety modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate acute onset of anxiolytic activity using a dental anxiety model, 89 patients were randomised to double-blind single dose pregabalin 150 mg, alprazolam 0.5 mg or placebo 4 h before a scheduled dental procedure. A Dental Anxiety Total score >12 (moderate-to-severe) without meeting Diagnostic and Statistical Manual of Mental Disorders (Fourth edition) (DSM-IV) anxiety disorder criteria was required. Efficacy and safety, assessed 2, 2.5, 3, 3.5 and 4 h postdose, included 100 mm Visual Analogue Scale for Anxiety (VAS-Anxiety; primary outcome), 100 mm VAS-Sedation and Time-to-Onset of Action Scale (TOAS), a patien...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Nutt, D., Mandel, F., Baldinetti, F. Tags: Articles Source Type: journals

Med Sci Monit 2009; 15(11):PI55-60 "The effects of alprazolam on tinnitus: A cross-over randomized clinical trial"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that although alprazolam did not improve the THI score or sensation level of loudness significantly, it has a desirable effect on VAS. Further work is needed to determine the beneficial effects of alprazolam in distressed or depressed patients. (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 19, 2009 Category: Research Tags: Original article Source Type: journals

Alprazolam/escitalopram: Acute dyskinesia and extrapyramidal symptoms in a child: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 21, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Inadequate Dose of Opioid-agonist Medication is Related to Misuse of BenzodiazepinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The inadequate dose of OAM in opioid substitution treatment for opioid-dependent patients seems to be related to the misuse of benzodiazepines. (C) 2009 Lippincott Williams & Wilkins, Inc. (Source: Addictive Disorders & Their Treatment)
Source: Addictive Disorders & Their Treatment - August 31, 2009 Category: Addiction Tags: Original Articles Source Type: journals

Pre-medication and renal pre-conditioning: a role for alprazolam, atropine, morphine and promethazineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggested a protective effect of these pre-medication drugs on I/R injury. Although obvious studies are required, these findings may lead to effective therapies against I/R injury. (Source: Fundamental and Clinical Pharmacology)
Source: Fundamental and Clinical Pharmacology - August 16, 2009 Category: Drugs & Pharmacology Authors: Hamid Reza Pazoki-Toroudi, Marjan Ajami, Rouhollah Habibey Source Type: journals

New to forum, 3rd day on suboxone...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: jamez70 Posted: Thu Aug 13, 2009 12:22 am Diary, I have had SEVERE SEVERE anxiety in my life. Let me try to describe it. Suddenly, out of nowhere, I have a severe panic attack without any real reason (no phobia). I try to go on.. That night, I have another one. I then become afraid to sleep in my bed, because I associate it with the panic attack. Then about 8 hours later, I have another one. Then I wonder "whats wrong with me? Do I have a tumor? Did I have a stroke?".. Then they keep coming and coming. Eventually, I enter a constant state of se...
Source: Suboxone Forum - August 12, 2009 Category: Addiction Source Type: forums

New to forum, 3rd day on suboxone...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: tekno Posted: Tue Aug 11, 2009 4:14 am MD, Klon 3 x qd will turn into more more more. Think about this. You have the restraint to scale back your dose of suboxone, even though the 16mg a day could help with your stress. But you don't have the restraint to not take 1.5mg of klonopin qd. You are taking it as prescribed, for now. You are doing so because you "like the feeling". If you were being your stubborn self you would have told yourself, "I am not going to take these damn benzo's unless I REALLY get stressed out." Either take them prn...
Source: Suboxone Forum - August 11, 2009 Category: Addiction Source Type: forums

Alprazolam/diazepam: Dependence: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - August 10, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

another quitting story.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: fairweathered Posted: Thu Aug 06, 2009 9:41 pm Hello everybody! I justed wanted to come in and share my experiences with everyone. I used opiates for two years before going onto suboxone. Everything was going pretty well for the most part until I had some problems with the damned doctors office. They used to refill my script for me over the phone, until they changed practices and couldn't do that anymore. This was a bit of a problem as I couldn't get a follow appointment for over a week, they were less than understanding to say the least. I only had a few &q...
Source: Suboxone Forum - August 6, 2009 Category: Addiction Source Type: forums

Xanax (Alprazolam) - updated on RxListEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Xanax (Alprazolam) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - August 1, 2009 Category: Drugs & Pharmacology Source Type: consumer

Selective effects of benzodiazepines on the acquisition of conditioned taste aversion compared to attenuation of neophobia in C57BL/6 miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Introduction The effects of pre-conditioning administration of anxiolytic benzodiazepines on the acquisition of a conditioned taste aversion (CTA) and on the acquisition of attenuation of neophobia (AN) were investigated in C57BL/6 mice. Materials and methods A CTA was induced by injecting lithium chloride (LiCl; 6 mEq . kg−1) 30 min after the animal had imbibed a novel 0.5% saccharin solution. In other animals, neophobia was attenuated by a single access to the novel 0.5% saccharin solution, followed only by injection of saline. Results and discussion &nbs...
Source: Psychopharmacology - July 25, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

From lexapro to subutex, vyvanse and xanaxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: mj Posted: Wed Jul 22, 2009 2:49 am Wow, I can't imagine how that must feel to go without sleep for so long. With your addiction history it sounds like you probably would not need vyvanse since it is a stimulant. This will probably only increase your daily anxiety even more. I took Cymbalta at one time and it made me anxious so I switched to lexapro-which helped for quite a while then started making me too tired. I am weaning off of Wellbutrin now that I am on Suboxone for opiate addiction. I feel better when not taking the Wellbutrin, the suboxone alone is ...
Source: Suboxone Forum - July 22, 2009 Category: Addiction Source Type: forums

Induction ProblemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: Highways Posted: Tue Jul 21, 2009 7:54 pm Thank you to both of you who replied. In response to reply number 1, that was great advice. To answer your first question, my average daily oxy dose was about 160 mg. I am getting the subs from a doctor, but I recently relocated to a new city for a new job, and in the process of moving and all, I had to find a new doctor in my new city, so it took a little while to do, and that is why I most recently relapsed and gone back to using oxy, but now that I have found a doctor and have a new script for subs, I am planning...
Source: Suboxone Forum - July 21, 2009 Category: Addiction Source Type: forums

Induction ProblemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: Highways Posted: Tue Jul 21, 2009 7:30 am Good Day All- I have been on and off Subs for about 6 months now, and Im at the point where I am sick of going back and forth from my drug of choice(oxycontin) to suboxone, and want to just get back on the suboxone for good. My problem is the induction. I dont know if it is because I was taking so much of the painkiller or that, it just takes a couple days to stabilize, or what, but when I wake up, and wait an hour or two until withdrawl kicks in, and then take my suboxone, I feel much much better than had I taken n...
Source: Suboxone Forum - July 21, 2009 Category: Addiction Source Type: forums

From lexapro to subutex, vyvanse and xanaxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: suboxdoc Posted: Sun Jul 19, 2009 9:26 pm I have a few thoughts, and I'm not sure where to start. The insomnia is likely because of the combination of cymbalta and vyvanse. Vyvanse is a long-acting stimulant; it is by far my favorite ADD medication to prescribe, as it has a very low risk of addiction compared to other stimulants. At the same time, your psychiatrist made some very aggressive medication changes in a very short period of time. I'm not going to pass judgment on a person I don't know, but in general you might want to change only one medication at...
Source: Suboxone Forum - July 19, 2009 Category: Addiction Source Type: forums

Contribution & The Fear of EverythingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Spiritual teacher David Deida has suggested that hidden within our biggest fear lies our greatest gift. The road to our most meaningful and powerful contribution in life often travels through the precise territory we most wish to avoid. I have found this to be true in my case, and I do not consider it to be good news; rather, by definition, I find it to be both frightening and anxiety-producing. I am by nature a somewhat socially phobic, introverted recluse who likes nothing better than staying home in my pajamas on a rainy day. It recalls when I'd be sick enough as a kid to warrant taking a legitima...
Source: Psychology Today Work Center - July 19, 2009 Category: Psychiatry & Psychology Authors: Eliezer Sobel Tags: Happiness Personality Psych Careers Psychiatry Psychotherapy Relationships Resilience Self-Help Sleep Spirituality Trauma Work anxiety Beatles butterfly effect courage dread fear God Jewish light Source Type: consumer

The Mothers Act Disease Mongering Campaign - Part IEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) The Mothers Act represents the ultimate example of disease mongering at its worst because the eight-year attempt to pass this federal legislation has evolved into profiteering never before exhibited so conspicuously.Disease mongering "is the selling of sickness that widens the boundaries of illness and grows the markets for those who sell and deliver treatments," according to Ray Moyniahan and David Henry in the April 11, 2006 paper in PLoS Med, titled, "The Fight against Disease Mongering." "It is exemplified most explicitly by many pharmaceutical industry -- funded disease-awareness campaigns -- more often ...
Source: NaturalNews.com - July 16, 2009 Category: Consumer Health Advice Source Type: news

Michael jackson a junkie?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: Euphemism Posted: Mon Jul 13, 2009 7:51 am LOL.... I was gonna say that 250mg of Xanax each day seems impossible. 2mg is a big dose. I used to use maybe 10-20mg/day and would fall asleep in all sorts of weird, inappropriate places. 250mg of Xanax per day would have definitely flat-lined MJ.... and if... by some miracle it didn't... his head would explode if he ever had to go a day without it. Also, I don't believe Dilaudid comes in a 3mg pill form. I suppose he could have been taking a 2mg + a 1mg each dose, or been using the liquid form, but most doctors w...
Source: Suboxone Forum - July 13, 2009 Category: Addiction Source Type: forums

Either way you lose.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Author: suboxdoc Posted: Sat Jul 11, 2009 11:50 pm I firmly believe that people on Suboxone are as 'clean' as anyone going to meetings and not using-- I see as much personality growth and good things with Suboxone-- if not more. That said, you are likely still in 'addict' mode. I am huge on dosing ONCE per day with Suboxone; we know that for almost everyone, 4 mg is equivalent in opiate potency to 8, 12, 16, 24, or 32 (!) mg. The company that makes Suboxone has been sending notices out every month for over a year now, telling docs to limit doses to a MAX of 16 mg-...
Source: Suboxone Forum - July 11, 2009 Category: Addiction Source Type: forums

Alprazolam prescribing in Tasmania: a two-fold intervention designed to reduce inappropriate prescribing and concomitant opiate prescription.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Education can be an effective strategy to influence prescribing behaviour of doctors. It is likely that this effect can be augmented by adoption of more stringent regulatory requirements. PMID: 19585293 [PubMed - in process] (Source: Australasian Psychiatry)
Source: Australasian Psychiatry - July 10, 2009 Category: Psychiatry Authors: Hooper S, Bruno R, Sharpe M, Tahmindjis A Tags: Australas Psychiatry Source Type: journals

Portrait of Jackson's pill consumption emergesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Singer Michael Jackson took more than 10 Xanax pills a night, asking his employees to get the prescription medicine under their names and also personally traveling to doctors' offices in other states to obtain them, said a confidential document from 2004 that CNN obtained Thursday. (Source: CNN.com - Health)
Source: CNN.com - Health - July 10, 2009 Category: Consumer Health News Source Type: news

[Benzodiazepine use in a sample of patients on a treatment program with opiate derivatives (PTDO).]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions; BZ-use data and their relationship to time spent on methadone are similar to those of other published studies. Despite the recommendation to use long half-life BZ in patients with substance abuse disorders, it is striking that in the case studied here the most widely prescribed type is alprazolam. PMID: 19578731 [PubMed - in process] (Source: Adicciones)
Source: Adicciones - July 8, 2009 Category: Addiction Authors: Fernández Sobrino AM, Fernández Rodríguez V, López Castro J Tags: Adicciones Source Type: journals

Obscene Drug Profits: Where They GoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) Recently, a couple of Federal Budget Analysts from Washington, DC wondered about the profits in pharmaceutical drugs and came up with some interesting figures. Turns out that to purchase the active ingredients for many drugs is often pennies, while a hundred dollar plus price tag is passed on to consumers.They found a 100 tablets of 20 mg Prozac runs the consumer about $247.47, while the active ingredients only cost $0.11. Yes, that's right. Eleven cents for all one hundred tablets. It's a 224,973 percent mark-up, a profit margin most business owners dream of - but could never get away with.Even more profitab...
Source: NaturalNews.com - July 6, 2009 Category: Consumer Health Advice Source Type: news

Health News of the DayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day.The coldest job on earth: doctor on Antarctica’s only international base http://bit.ly/18tNlVMonitoring bone mineral density in the first three years after starting treatment with bisphosphonate is unnecessary, BMJ http://is.gd/1foCWReport: Inexperienced doctors may fail to spot warning signs http://bit.ly/2dk6mMFactors associated with mortality in patients receiving methadone in primary care, BMJ: 8% people died http://bi...
Source: Clinical Cases and Images - June 29, 2009 Category: Journals (General) Tags: Health News of the Day Source Type: info

Was Michael Jackson Chemically Manipulated for Profit?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) Michael Jackson's death gives us an opportunity to reflect on the way he was treated by the media (and the public) while he was alive. Through his work, Michael Jackson went to great lengths to send a message of love to the world -- to inspire others and add joy to our lives -- and yet he was derided as a monster by the tabloid media while being humiliated by the comedy routines of late-night talk show hosts.Western culture is cruel to celebrities.Anyone in a position of notoriety is automatically deemed a fair target for outrageous accusations and slander. As somewhat of a minor celebrity (in a narrow field)...
Source: NaturalNews.com - June 29, 2009 Category: Consumer Health Advice Source Type: news

Suffering, Seeking & SanityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It's 1976, and I'm speaking to Karen, my partner at the time, bemoaning my lack of commitment to anything. All of my close friends over the years, up to and including my wife, Shari, will attest to the fact that I am a habitual bemoaner. (Be·moan: "To express grief or disappointment about something." In Yiddish, it is translated to "kvetch," which adds the elements of whining and complaining. It could be argued that, depending on my audience, I am both a bemoaner and a kvetcher.)In any event, those with the supernatural ability to see auras and animated cartoon icons appear in real life would have seen a...
Source: Psychology Today Anxiety Center - June 12, 2009 Category: Psychiatry & Psychology Authors: Eliezer Sobel Tags: Anxiety Depression Happiness Philosophy Psychiatry Self-Help Spirituality Therapy alternative therapies ancient religions animated cartoon approaches to psychology bipolar Buddhism consistent commitment endless work enlight Source Type: consumer

Caffeine augments Alprazolam induced cytotoxicity in human cell lines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Combined effects of alprazolam (Alp), a member of benzodiazepine group of drugs and caffeine on human cell lines, HeLa and THP1 were investigated in this study. Alp mediated cytotoxicity was enhanced while caffeine was present. The cell death was confirmed by observing morphological changes, LDH assay and membrane anisotropic study. Also such combined effects induced elevated level of ROS and depletion of GSH. The mechanism of cell death induced by simultaneous treatment of Alp and caffeine was associated with the calcium-mediated activation of mu-calpain, release of lysosomal protease cathepsin B, activation of PARP a...
Source: Toxicology in Vitro - May 30, 2009 Category: Toxicology Authors: Saha B, Mukherjee A, Samanta S, Saha P, Ghosh AK, Santra CR, Karmakar P Tags: Toxicol In Vitro Source Type: journals

Chimpanzee Was On Anti-Anxiety Drug XanaxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Travis the chimpanzee — whose presence in a Stamford home had been called an "accident waiting to happen" months before he attacked Charla Nash — had the anti-anxiety drug Xanax in his system, according to the state's attorney's office. It is... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - May 14, 2009 Category: American Health Source Type: news

Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Even though fear-potentiated startle may be used to translate preclinical evidence to human populations, methodological issues still hamper the application of this model to early screening of putative anxiolytic drugs. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1516-5Authors J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsN. Mol, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, He...
Source: Psychopharmacology - May 5, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Does oral alprazolam affect ventilation? A randomised, double-blind, placebo-controlled trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AbstractThe respiratory effects of benzodiazepines have been controversial. This investigation aimed to study the effects of oral alprazolam on ventilation. In a randomised, double-blind cross-over protocol, 20 healthy men ingested 1 mg of alprazolam or placebo in random order, 1 week apart. Ventilation was unobtrusively monitored by inductance plethysmography along with end-tidal PCO2 and pulse oximetry 60–160 min after drug intake. Subjects were encouraged to keep their eyes open. Mean ± SD minute ventilation 120 min after alprazolam and placebo was similar (6.21 ±&n...
Source: Journal of Psychopharmacology - April 24, 2009 Category: Psychiatry Authors: Carraro, G., Russi, E., Buechi, S, Bloch, K. Tags: Article Source Type: journals

Weight Management MythsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
All eating is emotional. The tough part is choosing which group of emotions you want to motivate your eating. That was the argument of my previous post. This one reveals myths that make the choice unnecessarily difficult.Myth #2: When I lose weight I will value myself more. Weight loss programs reinforce this message, both directly, by asking you to "Think about how you don't like looking the in the mirror," and indirectly, with their emphasis on "goals" and "rules."Oh they say, "You should accept yourself fat," and "Keep going, even if you relapse," and that sort of thing. But no amount of lip service can counteract the e...
Source: Psychology Today Food and Diet Center - March 28, 2009 Category: Nutrition Authors: Steven Stosny Tags: Anxiety Diet Happiness Health Self-Help diets weight loss weight management Source Type: consumer

Anxiety MedicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antianxiety medications help to calm and relax the anxious person and remove the troubling symptoms. There are a number of antianxiety medications currently available. The preferred medications for most anxiety disorders are the benzodiazepines such as Valium, Xanax/Zanex, and Ativan. (Source: About.com Mental Health)
Source: About.com Mental Health - March 14, 2009 Category: Psychiatry Tags: health Source Type: consumer

Medications for AnxietyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Medications for anxiety benzodiazepines clonazepam Klonopin alprazolam Xanax diazepam Valium lorazepam Ativan buspirone buspar propranolol Inderal Inderide (Source: About.com Mental Health)
Source: About.com Mental Health - March 14, 2009 Category: Psychiatry Tags: health Source Type: consumer

Virtual Reality, Psychotherapy, Show Promise in Treating PTSD Symptoms; Civilian Access to Care Remains a ConcernEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Early data from an NIMH-sponsored double-blind study of 24 war veterans shows a marked reduction in acoustic startle ─ the reflex response to sudden loud sounds ─ in those treated with virtual reality exposure therapy combined with either d-cycloserine, an antibiotic that has been shown to facilitate the extinction of fear memories; pill placebo; or the anti-anxiety medication alprazolam (Xanax). (Source: National Institute of Mental Health)
Source: National Institute of Mental Health - March 7, 2009 Category: Psychiatry Authors: National Institute of Mental Health Source Type: organizations

Xanax Side EffectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Catalogue of side effects for Xanax / Alprazolam, an antianxiety medication which may be prescribed for the treatment of bipolar disorder / manic depression and other mental disorders. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 7, 2009 Category: Psychiatry Tags: health Source Type: consumer

BenzodiazepinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Information about the benzodiazepine family of medications, generally used to treat anxiety and related conditions, including Valium, Librium, Xanax and several others. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 7, 2009 Category: Psychiatry Tags: health Source Type: consumer

Effect of smoking and CYP2D6 polymorphisms on the extent of fluvoxamine–alprazolam interaction in patients with psychosomatic diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The extent of interaction between FVX and ALP may be affected by smoking, which alters the C/D ratio of FVX. Therefore, when FVX and ALP are concomitantly administered, it should be noted that non-smokers may exhibit greater drug interaction than smokers. Content Type Journal ArticleCategory Pharmacokinectics and DispositionDOI 10.1007/s00228-009-0629-4Authors Hideyo Sugahara, Kyushu University Department of Psychosomatic Medicine, Graduate School of Medical Sciences Fukuoka JapanChiharu Maebara, Kyushu University Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceuti...
Source: European Journal of Clinical Pharmacology - February 19, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Crazed Chimp Was on Xanax During Attack?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Animal experts say chimp that mauled Conn. woman was on medication. (Source: ABC News: Health)
Source: ABC News: Health - February 18, 2009 Category: Consumer Health News Source Type: news

A comparison of the effects of a subtype selective and non-selective benzodiazepine receptor agonist in two CO2 models of experimental human anxietyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our results show that zolpidem shows some anxiolytic efficacy in the 7.5% CO2 model, similar to alprazolam, and this is the first report of such an effect of zolpidem in a model of anxiety. These and other studies of benzodiazepines in clinical and volunteer studies suggest a definite role of the GABA-A receptor in CO2-induced anxiety, and it would be of interest to examine other GABA-A receptor subtype selective drugs, which are now in early phase clinical studies and are showing selective efficacy in pharmacodynamic studies. (Source: Journal of Psychopharmacology)
Source: Journal of Psychopharmacology - February 12, 2009 Category: Psychiatry Authors: Bailey, J., Papadopoulos, A, Seddon, K, Nutt, D. Tags: Article Source Type: journals

Bipolar Disorder Fact SheetEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
All of us experience changes in our moods. Some days we might feel irritable and frustrated; other days, we’re happy and excited. However, individuals with bipolar disorder experience severe mood swings that impair their daily life and negatively affect their relationships. Approximately 2.6 percent of American adults have bipolar disorder (formerly called manic depression and manic depressive disorder), according to the National Institute of Mental Health. These mood swings include “highs” (mania), when individuals feel either on top of the world or on edge, and “lows” (depression), when they feel sad and hope...
Source: Psych Central - February 6, 2009 Category: Psychiatry Authors: Margarita Tags: General Disorders Psychology Psychotherapy Medications Antidepressants Antipsychotics Bipolar Treatment Mood Stabilizers Benzodiazepines Atypical Antipsychotics Source Type: consumer

[Maximal initiative dose of simvastatin causing acute renal failure through rhabdomyolysis: risk factors, pathomechanism and therapy related to a case.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: On account of risk factors listed above this case should have been administered to low initial dose of SIM. Developing myalgia or weekness in muscles, treatment must be stopped. In a case of predisposition to RML statin therapy and dosage can only be performed under continous supervision. PMID: 19179259 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - February 1, 2009 Category: Journals (General) Authors: Deme D, Al-Hadad A, Varga T, Szántó E, Sándor K, Rakonczai E Tags: Orv Hetil Source Type: journals

Alprazolam treatment immediately after stress exposure interferes with the normal HPA-stress response and increases vulnerability to subsequent stress in an animal model of PTSD.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A brief course of alprazolam in the immediate aftermath of stress-exposure is associated with less favorable responses to additional stress-exposure later on. Alprazolam was associated with a significant attenuation of the HPA-response, suggesting a possible link between initial HPA-axis response disruption and the subsequent unfavorable outcomes. PMID: 19167197 [PubMed - as supplied by publisher] (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - January 22, 2009 Category: Psychiatry & Psychology Authors: Matar MA, Zohar J, Kaplan Z, Cohen H Tags: Eur Neuropsychopharmacol Source Type: journals

Dogs as Therapists: The Case of Actor Mickey RourkeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On January 11, 2009 Mickey Rourke won the Golden Globe Award for best actor for his performance in Darren Aronofsky's "The Wrestler." When actors give acceptance speeches for such awards it is quite common for them to thank God and their family for the win, but Mickey Rourke thanked his dogs. If it had not been for the therapeutic effects of his relationship with his dogs, Mickey Rourke might not have been alive to accept this award. In the film, "The Wrestler," Rourke plays the part of Randy "The Ram" Robinson, a professional wrestler who is now well past his prime, holding on to the remains of a once-famous career, and p...
Source: Psychology Today Depression Center - January 16, 2009 Category: Psychiatry & Psychology Authors: Stanley Coren, Ph.D. Tags: Depression Health Pets Psychotherapy Relationships Aaron Katcher acceptance speeches actor Alan Beck alan parker angel heart antidepressant antiheroes blood pressure career decisions cinema comic book series darren aronof Source Type: consumer

Azur Pharma Announces the Licensing of Niravam, Parcopa, Kemstro and Fluxid From UCBEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two Marketed CNS Products With U.S. Revenues of $20 Million Two FDA Approved but Unlaunched Products DUBLIN, Ireland, January 9 (HSMN NewsFeed) -- Azur Pharma Limited ("Azur Pharma") today announced that it licensed the exclusive U.S. market... Biopharmaceuticals, LicensingAzur Pharma, UCB, Niravam, Parcopa, Kemstro, Fluxid (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - January 9, 2009 Category: Pharmaceuticals Source Type: news

Freebies, FarewellEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It seems there will be no more Zyprexa pen-knives, Prozac mugs, or Zoloft soap dispensers. Drug companies have agreed to a moratorium on free branded goodies for doctors.I have the sense of having lived through a full cycle of a public health political movement. When I started medical school, one of our first student meetings concerned free stethoscopes. A pharmaceutical house supplied them. Some politically aware classmates believed that to accept these gifts corrupted doctors. The solution was to gather the instruments in bulk and send them to a less well-stocked Latin American country - my memory is Nicaragua, but I'm h...
Source: Psychology Today Depression Center - January 8, 2009 Category: Psychiatry & Psychology Authors: Peter D. Kramer Tags: Depression big pharma classmates clozaril dermatologists flash drives handfuls latin american country medical meeting meeting hall paperweights pen knives pharmaceutical houses prozac psychiatric medications psychiatry psyc Source Type: consumer

ALPRAZOLAM XR (Alprazolam) Tablet, Extended Release [Greenstone LLC]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Jan 5, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - January 5, 2009 Category: Drugs & Pharmacology Source Type: organizations

Panic disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New evidence; conclusions changed for: CBT versus drug treatments Existing evidence re-evaluated, and reporting in benefits section further enhanced with additional detail. Existing categorisation changed. 'CBT versus antidepressants (unclear which more effective, but weak evidence that effects of CBT may last longer than those of antidepressants)' categorised as Unknown effectiveness. CBT plus drug treatments versus drugs alone One systematic review (search date 2005) added which includes a meta-analysis for short- and long-term results.Benefits and harms data enhanced. Categori...
Source: Clinical Evidence - December 16, 2008 Category: Journals (General) Source Type: journals

Analytical study proving alprazolam degradation to its main impurity triazolaminoquinoleine through Maillard reaction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Triazolaminoquinoleine is rapidly formed in formulations of alprazolam tablets in presence of excipients, and its generation is speeded up with increasing temperature and humidity. The present paper deals with detailed quantitative and qualitative studies into the nonactive constituents of the formulation in order to determine the excipient (or the mixture) responsible for the degradation. Our studies have demonstrated that reducing carbohydrate excipients play a fundamental role in the generation of triazolaminoquinoleine, with lactose as the main one responsible, through a Maillard reaction. In order to demonstrate t...
Source: Analytical and Bioanalytical Chemistry - December 10, 2008 Category: Chemistry Authors: Huidobro AL, Barbas C Tags: Anal Bioanal Chem Source Type: journals

Contribution of α1 subunit-containing γ-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These experiments demonstrate dose-dependent motor impairment in squirrel monkeys using quantitative behavioral observation techniques. Altogether, these findings suggest a lack of a prominent role for α1 subunit-containing receptors in the alteration of hind-limb flexion, a putative measure of myorelaxation, induced by BZ-type drugs in monkeys. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-008-1401-7Authors Stephanie C. Licata, McLean Hospital/Harvard Medical School Belmont MA USADonna M. Platt, Harvard Medical School New England Primate Research Center On...
Source: Psychopharmacology - November 25, 2008 Category: Psychiatry Tags: Psychopharmacology Source Type: journals