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Specialized Dementia Care UnitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract available
Source: Alzheimer Disease and Associated Disorders - July 5, 2009 Category: Geriatrics Tags: Book Reviews: PDF Only Source Type: journals

An Open-label Study of Memantine Treatment in 3 Subtypes of Frontotemporal Lobar DegenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this study were to explore the tolerability of memantine treatment in FTLD and to monitor for possible effects on behavior, cognition, and function. Forty-three individuals who met clinical criteria for FTLD [21 with frontotemporal dementia (FTD), 13 with semantic dementia (SD), and 9 with progressive nonfluent aphasia (PA)] received 26 weeks of open-label treatment with memantine at a target dose of 20 mg daily. Concurrent treatment with acetylcholinesterase inhibitors was prohibited. Cognitive and functional outcome measures included the Mini Mental State Examination, Alzheimer's Disease Assessment Scal...
Source: Alzheimer Disease and Associated Disorders - July 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Concepts, Conjectures, and Hypotheses in DementiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract available
Source: Alzheimer Disease and Associated Disorders - July 1, 2009 Category: Geriatrics Tags: Editorial Source Type: journals

Cardiorespiratory Fitness and Preserved Medial Temporal Lobe Volume in Alzheimer DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exercise and cardiorespiratory (CR) fitness may moderate age-related regional brain changes in nondemented (ND) older adults. The relationship of fitness to Alzheimer disease (AD)-related brain change is understudied, particularly in the hippocampus, which is disproportionately affected in early AD. The role of apolipoprotein E4 (apoE4) genotype in modulating this relationship is also unknown. ND (n=56) and early-stage AD patients (n=61) over the age of 65 years had magnetic resonance imaging and CR fitness assessments. Voxel-based morphometry techniques were used to identify AD-related atrophy. We analyzed the relationshi...
Source: Alzheimer Disease and Associated Disorders - July 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Computer-based Cognitive Training for Mild Cognitive Impairment: Results from a Pilot Randomized, Controlled TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We performed a pilot randomized, controlled trial of intensive, computer-based cognitive training in 47 subjects with mild cognitive impairment. The intervention group performed exercises specifically designed to improve auditory processing speed and accuracy for 100 min/d, 5 d/wk for 6 weeks; the control group performed more passive computer activities (reading, listening, visuospatial game) for similar amounts of time. Subjects had a mean age of 74 years and 60% were men; 77% successfully completed training. On our primary outcome, Repeatable Battery for Assessment of Neuropsychological Status total scores improved 0.36 ...
Source: Alzheimer Disease and Associated Disorders - July 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

[beta]-thalassemia Trait as a Protective Factor Against Alzheimer DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract available
Source: Alzheimer Disease and Associated Disorders - July 1, 2009 Category: Geriatrics Tags: Concepts, Conjectures, and Hypotheses in Dementia Source Type: journals

Parkinson Disease With Dementia: Comparing Patients With and Without Alzheimer PathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests that it is difficult to distinguish PDD+AD and PDD-AD on the basis of movement, clinical, and neuropsychologic assessment. PDD-AD and PDD+AD have similar degrees of dementia and approximately half of PDD subjects have enough AD pathology to attain a neuropathologic diagnosis of AD. PDD can develop in the absence of significant Alzheimer pathology. (C) 2009 Lippincott Williams & Wilkins, Inc.
Source: Alzheimer Disease and Associated Disorders - July 1, 2009 Category: Geriatrics Tags: Brief Reports Source Type: journals

Rate of Decline in Alzheimer Disease Measured by a Dementia Severity Rating ScaleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The DSRS provides a clinical measure of functional impairment in AD that increases about 4.48 points/y from the earliest symptomatic stage until patients become too severely impaired to return to clinic. (C) 2009 Lippincott Williams & Wilkins, Inc.
Source: Alzheimer Disease and Associated Disorders - July 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Prevention of Dementia by Intensive Vascular Care (PreDIVA): A Cluster-randomized Trial in ProgressEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this older age group, the very high percentage of elderly subjects with cardiovascular risk factors illustrates the large window of opportunity for therapies directed to lower the cardiovascular risk and potentially also the risk for dementia. (C) 2009 Lippincott Williams & Wilkins, Inc.
Source: Alzheimer Disease and Associated Disorders - July 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Higher Than Expected Progranulin Mutation Rate in a Case Series of Italian FTLD PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract available
Source: Alzheimer Disease and Associated Disorders - July 1, 2009 Category: Geriatrics Tags: Letters to the Editor Source Type: journals

Characteristics and Performance of a Modified Version of the ADCS-CGIC CIBIC+ for Mild Cognitive Impairment Clinical TrialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Change detected by the MCI-CGIC was associated with baseline clinical severity and with change in clinical ratings over 6 and 12 months, supporting the validity of a CGIC approach in MCI. The effect size of the donepezil-placebo difference was similar to that of other outcomes at 12 months. About 40% of MCI patients were judged worse and about 11% improved, consistent with clinical experience and other ratings. (C) 2009 Lippincott Williams & Wilkins, Inc.
Source: Alzheimer Disease and Associated Disorders - July 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Frontotemporal Dementia-amyotrophic Lateral Sclerosis Complex is Simulated by Neurodegeneration With Brain Iron AccumulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of late onset neurodegeneration with brain iron accumulation (NBIA) presenting as frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS). A male patient presented at age 66 with change of personality: disinhibition, emotional blunting, and socially inappropriate behavior, coupled with dysarthria, dystonia, and corticospinal tract involvement. Magnetic resonance imaging showed general cortical atrophy, iron deposits in the globus pallidus, and the "eye of the tiger" sign. Neuropsychologic performance was globally reduced, especially executive functions. Fluorodeoxyglucose positron emission...
Source: Alzheimer Disease and Associated Disorders - July 1, 2009 Category: Geriatrics Tags: Brief Reports Source Type: journals

Associations Between Microinfarcts and Other Macroscopic Vascular Findings on Neuropathologic Examination in 2 DatabasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinicians may undervalue brain microinfarcts because they are defined by neuropathology and not seen on magnetic resonance imaging (MRI). We sought to identify what neuropathologic vascular findings-likely to be evident on brain MRI during life-would predict the presence of microinfarcts. We sought associations between such findings and microinfarcts in neuropathology databases from the National Alzheimer's Coordinating Center (NACC) and the Adult Changes in Thought (ACT) study. Considering only subjects 65 years or older at death, microinfarcts were evaluated in 6189 from NACC and 219 from ACT. Despite different definiti...
Source: Alzheimer Disease and Associated Disorders - July 1, 2009 Category: Geriatrics Tags: Brief Reports Source Type: journals

Frequency and Causes of Early-onset Dementia in a Tertiary Referral Center in AthensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the distribution of patients diagnosis and differences in sex, education, dementia severity, cognitive function, and the duration of disease (from onset to referral) between the EOD (
Source: Alzheimer Disease and Associated Disorders - June 30, 2009 Category: Geriatrics Tags: Original Article: PDF Only Source Type: journals

Guidelines for Addressing Ethical and Legal Issues in Alzheimer Disease Research: A Position PaperEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract available
Source: Alzheimer Disease and Associated Disorders - June 16, 2009 Category: Geriatrics Tags: Original Article: PDF Only Source Type: journals

Determining the Competency of Alzheimer Patients to Consent to Treatment and ResearchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reports the findings of recent empirical studies of competency determination in AD, focusing on work in the areas of physician competency assessment, development of standardized assessment instruments, and neuropsychological modeling of competency loss. Future directions for research in these three areas are identified. (C) Lippincott-Raven Publishers.
Source: Alzheimer Disease and Associated Disorders - June 16, 2009 Category: Geriatrics Tags: Original Article: PDF Only Source Type: journals

The Alzheimer's Disease Centers' Uniform Data Set (UDS): The Neuropsychologic Test BatteryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The neuropsychologic test battery from the Uniform Data Set (UDS) of the Alzheimer's Disease Centers (ADC) program of the National Institute on Aging consists of brief measures of attention, processing speed, executive function, episodic memory, and language. This paper describes development of the battery and preliminary data from the initial UDS evaluation of 3268 clinically cognitively normal men and women collected over the first 24 months of utilization. The subjects represent a sample of community-dwelling, individuals who volunteer for studies of cognitive aging. Subjects were considered "clinically cognitively norm...
Source: Alzheimer Disease and Associated Disorders - April 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Dysphagia in Patients With Dementia: Alzheimer Versus VascularEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is noteworthy because it is one of the first attempts to differentiate between the swallowing symptoms of AD and VaD patients. A further study that includes patients with more severe degree of dementia (eg, patients over clinical dementia rating 3) might delineate additional discriminating swallowing patterns between the 2 dementia groups. In addition, a follow-up study exploring various kinematic characteristics of dysphagia would address physiologic issues of swallowing disorders as related to one of the most important clinical variables, laryngeal aspiration in the 2 dementia groups. (C) 2009 Lippincott Williams & Wilkins, Inc.
Source: Alzheimer Disease and Associated Disorders - April 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Safety and Tolerability of the Rivastigmine Patch: Results of a 28-week Open-label ExtensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The primary objective of the open-label extension was to evaluate the long-term safety and tolerability of a transdermal rivastigmine patch up to 1 year, as a novel approach to treatment in Alzheimer disease. This was a 28-week extension to a 24-week, double-blind, double-dummy, placebo-controlled, and active-controlled study evaluating rivastigmine patches [9.5 mg/24 h (10 cm2) and 17.4 mg/24 h (20 cm2)] and oral capsules (3 to 6 mg twice-daily). Patients entering the extension were switched directly to 9.5 mg/24 h rivastigmine patch and increased to 17.4 mg/24 h patch, irrespective of their double-blind study treatment. ...
Source: Alzheimer Disease and Associated Disorders - April 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Prevalence and Distribution of Cognitive Impairment no Dementia (CIND) Among the Aged Population and the Analysis of Socio-demographic Characteristics: The Community-based Cross-sectional StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The epidemiology on "cognitive impairment no dementia" (CIND) and its natural history are of great importance for understanding the transition from normal aging to dementia. Epidemiologic studies of CIND, however, are limited in China. The goal of our study was to determine the prevalence and distribution of CIND in the aged population and analyze socio-demographic factors. To accomplish this, we performed cluster random sampling of 6192 people aged over 65 years in Taiyuan, a metropolitan city located in northern China. Socio-demographic factors were surveyed by self-administered questionnaires. Neuropsychologic testing c...
Source: Alzheimer Disease and Associated Disorders - April 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Racial Differences in Knowledge and Beliefs About Alzheimer DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alzheimer disease (AD) is a growing public health problem that disproportionately affects racial and ethnic minorities, including African Americans. Given that the perceptions of illness can influence response to treatment options and coping with disease burden, we examined differences between African Americans and whites with regard to their attitudes, beliefs, and knowledge about AD. A total of 301 participants (mean age=57 y; 80% female; 47% African American) were surveyed by telephone, with overrepresentation of caregivers and first-degree relatives of people with AD (62% of sample). After controlling for potentially c...
Source: Alzheimer Disease and Associated Disorders - April 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Verbal Repetition in People With Mild-to-Moderate Alzheimer Disease: A Descriptive Analysis From the VISTA Clinical TrialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Verbal repetition is a common problem, and seems especially to be provoked by upcoming events. More frequent repetitions (shorter intervals between each repetition) were associated with goal setting around this problem. (C) 2009 Lippincott Williams & Wilkins, Inc.
Source: Alzheimer Disease and Associated Disorders - April 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Quality of Life and Burden of Spouses of Alzheimer Disease PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the study was to explore, in a sample of spouses of mild-to-moderate Alzheimer disease patients, predictors of quality of life (QoL) by rating QoL and burden. The authors assessed 97 spouses in a cross-sectional study with the Schedule for the Evaluation of Individual Quality of Life (SEIQoL), Self-Rated Burden scale (SRB), self-perceived stress scale (EDIZ; Ervaren Druk door Informele Zorg/Self-Perceived Pressure from Informal Care), and Zarit Burden Interview (ZBI). Patient cognition was rated with the Mini-Mental State Examination (MMSE). Factors best predicting QoL were analyzed with multiple regressio...
Source: Alzheimer Disease and Associated Disorders - April 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Recent Trends in Alzheimer Disease Mortality in the United States, 1999 to 2004Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have analyzed US Alzheimer disease (AD) mortality rates from 1999 to 2004, after 10th International Classification of Disease (ICD) revision coding made AD death certificate reporting more accurate. Age-standardized rates were calculated by year, age, sex, race, ethnicity, education, marital status, and geography. AD mortality increased 31% from 1999 to 2004. AD rates were higher in the northwest and the southeast. Stroke mortality shows a similar pattern; the correlation in state rates between stroke and AD is 0.79. Female AD mortality was 28% higher than male mortality. Whites had 56% higher rates than non-whites, and...
Source: Alzheimer Disease and Associated Disorders - April 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

High-throughput, Fully Automated Volumetry for Prediction of MMSE and CDR Decline in Mild Cognitive ImpairmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined whether measures of hippocampus, amygdala, and temporal horn volume predict clinical decline over the following 6-month period in patients with mild cognitive impairment (MCI). Fully automated volume measurements were performed in 269 MCI patients. Baseline volumes of the hippocampus, amygdala, and temporal horn were evaluated as predictors of change in Mini-mental State Examination and Clinical Dementia Rating Sum of Boxes over a 6-month interval. Fully automated measurements of baseline hippocampus and amygdala volumes correlated with baseline delayed recall scores. Patients with smaller baseline volu...
Source: Alzheimer Disease and Associated Disorders - April 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

The Effect of APOE-[varepsilon]4 on Dementia is Mediated by Alzheimer NeuropathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The degree to which the association of [varepsilon]4 with dementia is mediated by AD lesions in comparison with vascular lesions is controversial. The present study was undertaken to determine the roles of Alzheimer disease (AD) and vascular pathology in mediating the effect of apolipoprotein E (APOE)-[varepsilon]4 alleles on dementia. Clinicopathologic correlations were studied in 267 Catholic sisters participating in the Nun Study. The extent to which AD and vascular pathologies mediated the effect of APOE-[varepsilon]4 on dementia was investigated using multiple logistic regression. Adjusted for age at death and educati...
Source: Alzheimer Disease and Associated Disorders - April 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

The Spanish Translation and Adaptation of the Uniform Data Set of the National Institute on Aging Alzheimer's Disease CentersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers from Alzheimer's Disease Centers (ADCs) across the United States with expertise in the assessment of Spanish-speaking elderly collaborated to create the official Spanish version of measures in the Uniform Data Set of the National Institute on Aging Alzheimer's Disease Center Program. The present article describes this project, whose primary goal was to create Spanish instruments with cultural and linguistic equivalence to the English versions. The resulting Spanish versions make provisions for variations among Spanish-speaking groups in the United States of different nationalities, socio-cultural, linguistic, a...
Source: Alzheimer Disease and Associated Disorders - April 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Informant-based Dementia Screening in a Population-based Sample of African AmericansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: An informant-based screening tool for dementia may be useful in population-based studies of minority populations. Objective: Investigate the feasibility of screening for very mild dementia in a community sample of African Americans using an informant-based screening tool (AD8). Design: Cohort study. Participants: One hundred forty-seven persons from the African American Health (AAH) project were screened for dementia; 61 of 93 who were invited had follow-up clinical assessments for dementia diagnosis. Measurements: The AD8, Mini-Mental State Examination, Short Blessed Test, Brief Instrument for Dementia Detecti...
Source: Alzheimer Disease and Associated Disorders - April 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

The Validity of the Rowland Universal Dementia Assessment Scale (RUDAS) in a Multicultural Cohort of Community-dwelling Older Persons With Early DementiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The 6-item Rowland Universal Dementia Assessment Scale (RUDAS) is a simple, portable multicultural scale for detecting dementia. Items address executive function, praxis, gnosis, recent memory, and category fluency. It can be directly translated to other languages, without the need to change the structure or the format of any item. The RUDAS was administered to 151 consecutive, consenting, culturally diverse community-dwelling subjects of mean age 77 years, 72% of whom had an informant. Subjects were recruited from various clinics and healthcare programs. All were evaluated for cognitive impairment in a blinded manner by e...
Source: Alzheimer Disease and Associated Disorders - April 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Increased Atherogenic Lipoproteins are Associated With Cognitive Impairment: Effects of Statins and Subclinical Atherosclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 11DOI: 10.1097/WAD.0b013e3181850188Authors: Carlsson, Cynthia M. MD, MS * +; Nondahl, David M. MS ++; Klein, Barbara E. K. MD, MPH ++; McBride, Patrick E. MD, MPH, FACC [S]; Sager, Mark A. MD *; Schubert, Carla R. MS ++; Klein, Ronald MD, MPH ++; Cruickshanks, Karen J. PhD ++ [//]
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

Use of Statins and Risk of Hospitalization With Dementia: A Danish Population-based Case-control Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 18DOI: 10.1097/WAD.0b013e318180f55bAuthors: Horsdal, Henriette Thisted MSc * +; Olesen, Anne Vingard MSc ++ [S]; Gasse, Christiane Dr.rer.medic * [//]; Sorensen, Henrik Toft MD, DMSc * [P]; Green, Robert C. MD, MPH [P]; Johnsen, Soren Paaske MD, PhD *
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

Older Americans' Risk-benefit Preferences for Modifying the Course of Alzheimer Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 23DOI: 10.1097/WAD.0b013e318181e4c7Authors: Hauber, A. Brett PhD *; Johnson, F. Reed PhD *; Fillit, Howard MD +; Mohamed, Ateesha F. MA *; Leibman, Christopher PharmD, MS ++; Arrighi, H. Michael PhD ++; Grundman, Michael MD ++; Townsend, Raymond J. PharmD ++
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

What Belgian Neurologists and Neuropsychiatrists Tell Their Patients With Alzheimer Disease and Why: A National Survey.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 33DOI: 10.1097/WAD.0b013e31817d5e4cAuthors: Tarek, Meriem Essabiri MD; Segers, Kurt MD; Van Nechel, Christian MD
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

Validation of the Modified Telephone Interview for Cognitive Status in Amnestic Mild Cognitive Impairment and Intact Elders.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 38DOI: 10.1097/WAD.0b013e3181802c54Authors: Duff, Kevin PhD; Beglinger, Leigh J. PhD; Adams, William H. BA
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

The "Portable" CDR: Translating the Clinical Dementia Rating Interview into a PDA Format.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 44DOI: 10.1097/WAD.0b013e31817634a0Authors: Galvin, James E. MD, MPH *; Meuser, Thomas M. PhD * +; Coats, Mary A. MSN *; Bakal, Donald A. PhD ++ [S]; Morris, John C. MD *
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

A New Scale Measuring Psychologic Impact of Genetic Susceptibility Testing for Alzheimer Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 50DOI: 10.1097/WAD.0b013e318188429eAuthors: Chung, Winston W. BA *; Chen, Clara A. MHS +; Cupples, L. Adrienne PhD ++ [S]; Roberts, J. Scott PhD [//]; Hiraki, Susan C. MS *; Nair, Anil K. MD *; Green, Robert C. MD, MPH * [S] [P]; Stern, Robert A. PhD *
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

Regional Myo-inositol Concentration in Mild Cognitive Impairment Using 1H Magnetic Resonance Spectroscopic Imaging.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 57DOI: 10.1097/WAD.0b013e3181875434Authors: Siger, Malgorzata MD, PhD * +; Schuff, Norbert PhD *; Zhu, Xiaoping MD, PhD *; Miller, Bruce L. MD ++; Weiner, Michael W. MD *
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

Apolipoprotein E e4 Allele is Associated With More Rapid Motor Decline in Older Persons.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 63DOI: 10.1097/WAD.0b013e31818877b5Authors: Buchman, Aron S. MD * +; Boyle, Patricia A. PhD * ++; Wilson, Robert S. PhD * + ++; Beck, Todd L. MS [S]; Kelly, Jeremiah F. MD * [//]; Bennett, David A. MD * +
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

Activities of Daily Living in Behavioral Variant Frontotemporal Dementia: Differences in Caregiver and Performance-based Assessments.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 70DOI: 10.1097/WAD.0b013e318182d293Authors: Mioshi, Eneida MSc, OTR * +; Kipps, Christopher M. FRACP ++ [S]; Hodges, John R. FMedSci * + ++
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

Difficulties in Detecting Behavioral Symptoms of Frontotemporal Lobar Degeneration Across Cultures.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 77DOI: 10.1097/WAD.0b013e318182d874Authors: Papatriantafyllou, John D. MD *; Viskontas, Indre V. PhD +; Papageorgiou, Sokratis G. MD ++; Miller, Bruce L. MD +; Pavlic, Danijela BA +; Bingol, Ayse MD [S]; Yener, Gorsev MD, PhD [//]
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

Correlating DWI MRI With Pathologic and Other Features of Jakob-Creutzfeldt Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 82DOI: 10.1097/WAD.0b013e31818323efAuthors: Geschwind, Michael D. MD, PhD *; Potter, Christopher A. BA *; Sattavat, Mamta MS +; Garcia, Paul A. MD *; Rosen, Howard J. MD *; Miller, Bruce L. MD * ++; DeArmond, Stephen J. MD, PhD + ++
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

Expression of Apoptosis-related Proteins and of mRNA for Dopaminergic Receptors in Peripheral Blood Mononuclear Cells From Patients With Alzheimer Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 88DOI: 10.1097/WAD.0b013e318184807dAuthors: Cosentino, Marco MD, PhD *; Colombo, Cristina BcS, PhD *; Mauri, Marco MD +; Ferrari, Marco BcS *; Corbetta, Simona MD +; Marino, Franca BcS *; Bono, Giorgio MD +; Lecchini, Sergio MD *
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

Cardiovascular Risk Factors and Incident Alzheimer Disease: A Systematic Review of the Literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 1DOI: 10.1097/WAD.0b013e318187541cAuthors: Purnell, Christianna BA * +; Gao, Sujuan PhD ++; Callahan, Christopher M. MD * + ++; Hendrie, Hugh C. MB, ChB, DSc * + [S]
Source: Alzheimer Disease and Associated Disorders - March 2, 2009 Category: Geriatrics Tags: Abstract Source Type: journals

Cardiovascular Risk Factors and Incident Alzheimer Disease: A Systematic Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this review, the evidence that single clinically defined cardiovascular risk factors are significantly associated with incident AD is inconsistent at best. The strength of the association of cardiovascular risk factors and AD can be influenced greatly by changing the parameters of measurement of risk factors and by identifying interactions between the factors. (C) 2009 Lippincott Williams & Wilkins, Inc.
Source: Alzheimer Disease and Associated Disorders - January 1, 2009 Category: Geriatrics Tags: Review Article Source Type: journals

Increased Atherogenic Lipoproteins are Associated With Cognitive Impairment: Effects of Statins and Subclinical AtherosclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hypercholesterolemia increases the risk for dementia. Some studies suggest that statins may protect cognition, but findings are conflicting. Unmeasured confounders, including high-density lipoprotein (HDL) cholesterol or subclinical atherosclerosis, may have influenced prior study outcomes. In older adults participating in a population-based cohort study (n=1711, aged 65 to 97 y), we investigated the relationships of total and HDL cholesterol levels, statin use, and carotid intima-media thickness with the prevalence of cognitive impairment. In adjusted models, participants in the highest quartile of non-HDL (total-HDL) cho...
Source: Alzheimer Disease and Associated Disorders - January 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

Expression of Apoptosis-related Proteins and of mRNA for Dopaminergic Receptors in Peripheral Blood Mononuclear Cells From Patients With Alzheimer DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we found no evidence that PBMC from AD patients may express apoptosis-related proteins or DR mRNA to any different extent in comparison to cells from healthy subjects. These findings do not necessarily imply that immune cells cannot be exploited as biomarkers in AD (and in other central nervous system disorders). Future studies, however, should take into account the inherent complexity of the immune network. (C) 2009 Lippincott Williams & Wilkins, Inc.
Source: Alzheimer Disease and Associated Disorders - January 1, 2009 Category: Geriatrics Tags: Brief Report Source Type: journals

The "Portable" CDR: Translating the Clinical Dementia Rating Interview into a PDA FormatEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Clinical Dementia Rating (CDR) is a common rating system used in clinical trials and longitudinal research projects to rate the presence and severity of cognitive problems in Alzheimer disease and related disorders. The interview process requires training and can be time-consuming. Here, we describe the validity, reliability, and discriminative ability of a computer-generated CDR using a personal digital assistant format. This project used clinical data from 138 archival and live evaluations (patient and informant interviews) collected for research purposes at Washington University to develop and test a software-based ...
Source: Alzheimer Disease and Associated Disorders - January 1, 2009 Category: Geriatrics Tags: Original Articles Source Type: journals

The Metric Properties of Zarit Caregiver Burden Scale: Validation Study of a Chinese Version.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 321DOI: 10.1097/WAD.0b013e3181902334Authors: Wang, Gang MD, PhD *; Cheng, Qi MD, PhD * +; Wang, Ying MD *; Deng, Yu-lei MD *; Ren, Ru-jing MD, PhD *; Xu, Wei MD *; Zeng, Jie MD *; Bai, Li MD *; Chen, Sheng-di MD, PhD *
Source: Alzheimer Disease and Associated Disorders - December 3, 2008 Category: Geriatrics Tags: Abstract HTML PDF (109 K) Source Type: journals

Overlap in Frontotemporal Atrophy Between Normal Aging and Patients With Frontotemporal Dementias.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 327DOI: 10.1097/WAD.0b013e31818026c4Authors: Chow, Tiffany W. MD * + ++; Binns, Malcolm A. PhD +; Freedman, Morris MD, FRCPC * +; Stuss, Donald T. PhD * + [S]; Ramirez, Joel MA [S]; Scott, Chris J. M. BScH [S]; Black, Sandra MD, FRCPC * + [S]
Source: Alzheimer Disease and Associated Disorders - December 3, 2008 Category: Geriatrics Tags: Abstract HTML PDF (870 K) Source Type: journals

Effects of Hypertension and Hypercholesterolemia on Cognitive Functioning in Patients With Alzheimer Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 336DOI: 10.1097/WAD.0b013e318188e80dAuthors: Goldstein, Felicia C. PhD *; Ashley, Angela V. MD *; Endeshaw, Yohannes W. MD +; Hanfelt, John PhD ++; Lah, James J. MD, PhD *; Levey, Allan I. MD, PhD *
Source: Alzheimer Disease and Associated Disorders - December 3, 2008 Category: Geriatrics Tags: Abstract HTML PDF (115 K) Source Type: journals