Alzheimer's
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On your last nerve: Researchers advance understanding of stem cells
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Researchers have identified a gene that tells embryonic stem cells in the brain when to stop producing nerve cells called neurons. The research is a significant advance in understanding the development of the nervous system, which is essential to addressing conditions such as Parkinson's disease, Alzheimer's disease and other neurological disorders. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 20, 2009 Category: Science Source Type: news
Alzheimer's Society and Bupa unite to improve lives of people with dementiaEmail this article to a colleague.
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Bupa and Alzheimer's Society have today officially marked their joint commitment to the shared goal of improving the quality of care for people living with dementia. Their partnership was marked by signing a memorandum of understanding (Source: Alzheimers Society)
Source: Alzheimers Society - November 20, 2009 Category: Geriatrics Source Type: organizations
AFFiRiS AG: Interim Analysis Of Clinical Phase I Data Triggered Decision To Move Alzheimer's Vaccine Candidate AD02 Into Clinical Phase II TestingEmail this article to a colleague.
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AFFiRiS AG will focus its Alzheimer's vaccine program on one product candidate at an unexpectedly early stage of development: the vaccine candidate AD02 is planned to enter into Phase II clinical trial early in 2010. This decision by the company immediately follows the completion of two Phase I trials with the candidates AD01 and AD02. The company based its fast decision on the first interim analysis of the secondary endpoints at the six month time point. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Alzheimer's / Dementia Source Type: news
AFFiRiS AG: Interim Analysis Of Clinical Phase I Data Triggered Decision To Move Alzheimer's Vaccine Candidate AD02 Into Clinical Phase II TestingEmail this article to a colleague.
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AFFiRiS AG will focus its Alzheimer's vaccine program on one product candidate at an unexpectedly early stage of development: the vaccine candidate AD02 is planned to enter into Phase II clinical trial early in 2010. This decision by the company immediately follows the completion of two Phase I trials with the candidates AD01 and AD02. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
Surgery Not Linked To Memory Problems In Older PatientsEmail this article to a colleague.
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For years, it has been widely assumed that older adults may experience memory loss and other cognitive problems following surgery. But a new study from researchers at Washington University School of Medicine in St. Louis questions those assumptions. In fact, the researchers were not able to detect any long-term cognitive declines attributable to surgery in a group of 575 patients they studied. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
Surgery Not Linked To Memory Problems In Older PatientsEmail this article to a colleague.
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For years, it has been widely assumed that older adults may experience memory loss and other cognitive problems following surgery. But a new study from researchers at Washington University School of Medicine in St. Louis questions those assumptions. In fact, the researchers were not able to detect any long-term cognitive declines attributable to surgery in a group of 575 patients they studied. (Source: Alzheimer's / Dementia News From Medical News Today)
Source: Alzheimer's / Dementia News From Medical News Today - November 20, 2009 Category: Geriatrics Tags: Alzheimer's / Dementia Source Type: news
Interleukin-1 Gene --511 CT Polymorphism and the Risk of Alzheimer's Disease in a Polish PopulationEmail this article to a colleague.
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Dement Geriatr Cogn Disord 2009;28:461-464 (DOI:10.1159/000259460) (Source: Karger Publishers)
Source: Karger Publishers - November 19, 2009 Category: Cancer & Oncology Source Type: journals
Study: Neuroimaging may help characterize Alzheimer's riskEmail this article to a colleague.
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Automated morphological analysis techniques (MRI, diffusion tensor imaging and neurocognitive assessments) have shown the association of apolipoprotein E (ApoE4) allele in the brain of healthy, non-demented older adults with decrease in cognition, according to a study published in this month’s Journal of Alzheimer's Disease. (Source: Health Imaging News)
Source: Health Imaging News - November 19, 2009 Category: Radiology Tags: Latest News Source Type: news
MPEP Reduces Seizure Severity in Fmr-1 KO mice over Expressing Human Abeta.Email this article to a colleague.
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Metabotropic glutamate receptor 5 (mGluR(5)) regulates the translation of amyloid precursor protein (APP) mRNA. Under resting conditions, mRNA is bound to and translationally repressed by the fragile X mental retardation protein (FMRP). Upon group 1 mGluR activation, FMRP dissociates from the mRNA and translation ensues. APP levels are elevated in the dendrites of primary neuronal cultures as well as in synaptoneurosomes (SN) prepared from embryonic and juvenile fmr-1 knockout (KO) mice, respectively. In order to study the effects of APP and its proteolytic product Abeta on Fragile X syndrome (FXS) phenotypes, we creat...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Westmark CJ, Westmark PR, Malter JS Tags: Int J Clin Exp Pathol Source Type: journals
Neuropathology of non-Alzheimer degenerative disorders.Email this article to a colleague.
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Neurodegenerative diseases are characterized by selective and progressive loss of specific populations of neurons, which determines the clinical presentation. The same neuronal populations can be affected in a number of different disorders. Given that the clinical presentation reflects the particular population of neurons that are targets of the disease process, it is clear that for any given clinical syndrome, more than one neurodegenerative disease can account for the clinical syndrome. Because of this clinical ambiguity, for the purpose of this brief review neurodegenerative disorders are classified according to the...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Dickson DW Tags: Int J Clin Exp Pathol Source Type: journals
New Nursing Education Standards Address The Care Of People With DementiaEmail this article to a colleague.
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The NMC has been addressing many of the issues raised in the Alzheimer's society report Counting the Cost: caring for people with dementia on hospital wards as part of our review of pre-registration nursing education. Our review, which recently highlighted the need for future nurses to be educated to degree level, will help to prepare them for the challenges of caring for people with dementia. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
Free Personal Care For Older People In Their Own Home, UKEmail this article to a colleague.
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Alzheimer's Society has today welcomed the recognition of people with dementia in the Queen's speech and called for dementia to be a priority for all political parties. Responding to proposals to give people with the highest needs free personal care, Alzheimer's Society called for more detail and warned that both money and improved quality of home care was needed to make proposals a success. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
Collaboration With University Of Washington Aims To Prevent Dementia, Including Alzheimer'sEmail this article to a colleague.
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Every two years, 2,000 senior Group Health patients check in with the Adult Changes in Thought (ACT) study. The joint project between Group Health Research Institute and the University of Washington (UW) focuses on finding ways to delay or prevent dementia, including Alzheimer's disease, and declines in memory and thinking. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
Collaboration With University Of Washington Aims To Prevent Dementia, Including Alzheimer'sEmail this article to a colleague.
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Every two years, 2,000 senior Group Health patients check in with the Adult Changes in Thought (ACT) study. The joint project between Group Health Research Institute and the University of Washington (UW) focuses on finding ways to delay or prevent dementia, including Alzheimer's disease, and declines in memory and thinking. It aims to deepen understanding of how the body - especially the brain - ages. (Source: Alzheimer's / Dementia News From Medical News Today)
Source: Alzheimer's / Dementia News From Medical News Today - November 19, 2009 Category: Geriatrics Tags: Alzheimer's / Dementia Source Type: news
Free Personal Care For Older People In Their Own Home, UKEmail this article to a colleague.
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Alzheimer's Society has today welcomed the recognition of people with dementia in the Queen's speech and called for dementia to be a priority for all political parties. Responding to proposals to give people with the highest needs free personal care, Alzheimer's Society called for more detail and warned that both money and improved quality of home care was needed to make proposals a success. (Source: Alzheimer's / Dementia News From Medical News Today)
Source: Alzheimer's / Dementia News From Medical News Today - November 19, 2009 Category: Geriatrics Tags: Alzheimer's / Dementia Source Type: news
New Nursing Education Standards Address The Care Of People With DementiaEmail this article to a colleague.
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The NMC has been addressing many of the issues raised in the Alzheimer's society report Counting the Cost: caring for people with dementia on hospital wards as part of our review of pre-registration nursing education. Our review, which recently highlighted the need for future nurses to be educated to degree level, will help to prepare them for the challenges of caring for people with dementia. (Source: Alzheimer's / Dementia News From Medical News Today)
Source: Alzheimer's / Dementia News From Medical News Today - November 19, 2009 Category: Geriatrics Tags: Alzheimer's / Dementia Source Type: news
New Neuroimaging Analysis Technique Identifies Impact Of Alzheimer's Disease Gene In Healthy BrainsEmail this article to a colleague.
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Brain imaging can offer a window into risk for diseases such as Alzheimer's disease (AD). A study conducted at the University of Kansas School of Medicine demonstrated that genetic risk is expressed in the brains of even those who are healthy, but carry some risk for AD. The results of this study are published in the November 2009 issue of the Journal of Alzheimer's Disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
NC State Researchers Advance Understanding Of Stem CellsEmail this article to a colleague.
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Researchers from North Carolina State University have identified a gene that tells embryonic stem cells in the brain when to stop producing nerve cells called neurons. The research is a significant advance in understanding the development of the nervous system, which is essential to addressing conditions such as Parkinson's disease, Alzheimer's disease and other neurological disorders. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Stem Cell Research Source Type: news
NC State Researchers Advance Understanding Of Stem CellsEmail this article to a colleague.
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Researchers from North Carolina State University have identified a gene that tells embryonic stem cells in the brain when to stop producing nerve cells called neurons. The research is a significant advance in understanding the development of the nervous system, which is essential to addressing conditions such as Parkinson's disease, Alzheimer's disease and other neurological disorders. (Source: Alzheimer's / Dementia News From Medical News Today)
Source: Alzheimer's / Dementia News From Medical News Today - November 19, 2009 Category: Geriatrics Tags: Stem Cell Research Source Type: news
New Neuroimaging Analysis Technique Identifies Impact Of Alzheimer's Disease Gene In Healthy BrainsEmail this article to a colleague.
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Brain imaging can offer a window into risk for diseases such as Alzheimer's disease (AD). A study conducted at the University of Kansas School of Medicine demonstrated that genetic risk is expressed in the brains of even those who are healthy, but carry some risk for AD. The results of this study are published in the November 2009 issue of the Journal of Alzheimer's Disease. (Source: Alzheimer's / Dementia News From Medical News Today)
Source: Alzheimer's / Dementia News From Medical News Today - November 19, 2009 Category: Geriatrics Tags: Alzheimer's / Dementia Source Type: news
Review of Issue: Barriers to Hospice in Patients With AlzheimerEmail this article to a colleague.
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(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: Lippa, C. F. Tags: Articles Source Type: journals
Review: Obesity and Alzheimer's Disease: A Link Between Body Weight and Cognitive Function in Old AgeEmail this article to a colleague.
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Obesity is now a global health hazard. It not only predisposes to an array of risk factors leading to increased morbidity and mortality amongst adults but it also has a major negative impact on children’s health. The deleterious effects of obesity on cardiovascular system have now been well acknowledged. It causes insulin resistance that in turn leads to diabetes, hypertension and cardiovascular abnormalities. The vascular effects of obesity may have a role in the development of a rapidly growing disease of late life, Alzheimer’s disease. The precise mechanisms of the association between adiposity and impairmen...
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: Naderali, E. K., Ratcliffe, S. H., Dale, M. C. Tags: Articles Source Type: journals
The Effect of Multisensory Stimulation on Persons Residing in an Extended Care FacilityEmail this article to a colleague.
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Conclusion: The use of MSSE, as a non-pharmacological intervention, demonstrates the ability to decrease the number of incidences of disruptive or problematic behavior. The use of these interventions, where feasible, should be considered prior to the use of pharmacological methods. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: Ward-Smith, P., Llanque, S. M., Curran, D. Tags: Articles Source Type: journals
Progranulin and {beta}-Amyloid Distribution: A Case Report of the Brain From Preclinical PS-1 Mutation CarrierEmail this article to a colleague.
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Conclusions: This case report illustrates PGRN accumulation and Aβ aggregation in preclinical PS-1 AD case and raises the question whether this phenomenon coincides with or precedes Aβ aggregation. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: Gliebus, G., Rosso, A., Lippa, C. F. Tags: Articles Source Type: journals
Longitudinal Verbal Fluency in Normal Aging, Preclinical, and Prevalent Alzheimer's DiseaseEmail this article to a colleague.
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Conclusion: Greater longitudinal declines in category compared to letter fluency are consistent with cross-sectional studies. Steeper declines on both fluency measures distinguish preclinical AD from cognitively unimpaired individuals. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: Clark, L. J., Gatz, M., Zheng, L., Chen, Y.-L., McCleary, C., Mack, W. J. Tags: Articles Source Type: journals
The Role of Caregiver Prosody in Conversations With Persons Who Have Alzheimer's DiseaseEmail this article to a colleague.
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This study investigated whether aspects of family caregivers’ prosody (pitch and loudness) would be associated with successful or unsuccessful conversations with spouses who have Alzheimer’s disease (AD). Secondary analysis was conducted of 12 caregivers’ speech when interacting with spouses who have AD. Acoustic analyses were conducted to calculate the fundamental frequency (pitch) and intensity (loudness) of caregivers’ speech. The results showed no significant overall differences between the caregivers’ pitch or loudness in either successful or unsuccessful conversations. However, for 1 sub...
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: Small, J. A., Huxtable, A., Walsh, M. Tags: Articles Source Type: journals
Hospice Access for Individuals With DementiaEmail this article to a colleague.
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Involvement in a hospice program is important because it may allow individuals with dementia to delay or prevent institutionalization as well as provide psychosocial support for their families. Once used mostly by patients with a terminal cancer, now more than one half of the hospice patients have diagnoses other than cancer. Yet hospice is still underused for individuals dying with advanced dementia. We conducted a pilot study of hospice agencies to determine barriers and characteristics of dementia hospice enrollment. Using a mailed questionnaire and interview, we looked at demographics, accessibility, training, referral...
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Authors: McCarty, C. E., Volicer, L. Tags: Articles Source Type: journals
News BriefsEmail this article to a colleague.
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(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 19, 2009 Category: Geriatrics Tags: Articles Source Type: journals
Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's diseaseEmail this article to a colleague.
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Alzheimer's disease (AD) pathology is estimated to develop many years before detectable cognitive decline. Fluid and imaging biomarkers may identify people in early symptomatic and even preclinical stages, possibly when potential treatments can best preserve cognitive function. We previously reported that cerebrospinal fluid (CSF) levels of amyloid-[beta]42 (A[beta]42) serve as an excellent marker for brain amyloid as detected by the amyloid tracer, Pittsburgh compound B (PIB). Using data from 189 cognitively normal participants, we now report a positive linear relationship between CSF tau/ptau181 (primary constituents of ...
Source: EMBO Molecular Medicine - November 19, 2009 Category: Molecular Biology Authors: Anne M. Fagan, Mark A. Mintun, Aarti R. Shah, Patricia Aldea, Catherine M. Roe, Robert H. Mach, Daniel Marcus, John C. Morris, David M. Holtzman Source Type: journals
AIDS, UTI, Herpes Vaccines May Exist In 5 YearsEmail this article to a colleague.
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Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it. Many could be on the market in five years or less. Contrast that with five years ago, when so many companies had abandoned the vaccine business that half the U.S. supply of flu shots was lost because of factory contamination at one of the two manufacturers left. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 18, 2009 Category: Consumer Health News Source Type: consumer
Building a Legacy of HopeEmail this article to a colleague.
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He now is internationally recognized and renowned and in 1960, he entered the first University of Kentucky College of Medicine class. That is Dr. William R. Markesbery, who now is director of the UK Sanders-Brown Center on Aging and its Alzheimers Disease Center (ADC), Commonwealth Chair in Aging and professor of neurology, pathology, neurosurgery, and anatomy and neurobiology, UK College of Medicine. (Source: UK College of Medicine News)
Source: UK College of Medicine News - November 18, 2009 Category: Universities & Medical Training Tags: 7H000 appointment sanders brown Source Type: news
Free personal care for older people in their own homeEmail this article to a colleague.
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Alzheimer’s Society has today welcomed the recognition of people with dementia in the Queen’s speech and called for dementia to be a priority for all political parties. (Source: Alzheimers Society)
Source: Alzheimers Society - November 18, 2009 Category: Geriatrics Source Type: organizations
Vaccines on horizon for Alzheimer's, herpes, AIDSEmail this article to a colleague.
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Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it. (Source: CTV Health)
Source: CTV Health - November 18, 2009 Category: Consumer Health News Source Type: news
Vaccines on Horizon for AIDS, Alzheimer's, HerpesEmail this article to a colleague.
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From Associated Press (November 18, 2009)
MARIETTA, Pa._Malaria. Tuberculosis. Alzheimer's disease. AIDS.
Pandemic flu. Genital herpes. Urinary tract infections. Grass
allergies. Traveler's diarrhea. You name it, the pharmaceutical
industry is... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 18, 2009 Category: Pharmaceuticals Source Type: news
New Technology Drives Therapies For Older Patients, Those With Alzheimer'sEmail this article to a colleague.
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Technology advances are making life better for the elderly and those with Alzheimer's disease by allowing the older to stay in their homes and giving the ill a way to interact with society again. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
New Technology Drives Therapies For Older Patients, Those With Alzheimer'sEmail this article to a colleague.
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Technology advances are making life better for the elderly and those with Alzheimer's disease by allowing the older to stay in their homes and giving the ill a way to interact with society again. Kaiser Health News, in collaboration with (Source: Alzheimer's / Dementia News From Medical News Today)
Source: Alzheimer's / Dementia News From Medical News Today - November 18, 2009 Category: Geriatrics Tags: Alzheimer's / Dementia Source Type: news
Analyzing Structural Brain Changes In Alzheimer's DiseaseEmail this article to a colleague.
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In a study that promises to improve diagnosis and monitoring of Alzheimer's disease, scientists at the University of California, San Diego have developed a fast and accurate method for quantifying subtle, sub-regional brain volume loss using magnetic resonance imaging (MRI). The study is published the week of November 16 in the Proceedings of the National Academy of Sciences (PNAS). (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
Analyzing Structural Brain Changes In Alzheimer's DiseaseEmail this article to a colleague.
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In a study that promises to improve diagnosis and monitoring of Alzheimer's disease, scientists at the University of California, San Diego have developed a fast and accurate method for quantifying subtle, sub-regional brain volume loss using magnetic resonance imaging (MRI). The study is published the week of November 16 in the Proceedings of the National Academy of Sciences (PNAS). (Source: Alzheimer's / Dementia News From Medical News Today)
Source: Alzheimer's / Dementia News From Medical News Today - November 18, 2009 Category: Geriatrics Tags: Alzheimer's / Dementia Source Type: news
Activity-dependent gene transcription as a long-term influence on receptor signalling.Email this article to a colleague.
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The regulation of synaptic glutamate receptor and GABA(A)R (gamma-aminobutyric acid subtype A receptor) levels is a key component of synaptic plasticity. Most forms of neuronal plasticity are associated with the induction of the transcription factor zif268 (egr1). Hence, it is predicted that zif268 may regulate transcription of genes associated with glutamate receptors and/or GABA(A)Rs. It turns out that receptor regulation by zif268 tends to be indirect. Induction of zif268 in neurons leads to altered expression of proteasome subunit and proteasome-regulatory genes, thereby changing the capacity of the neuron to degra...
Source: Biochemical Society Transactions - November 18, 2009 Category: Biochemistry Authors: McDade DM, Conway AM, James AB, Morris BJ Tags: Biochem Soc Trans Source Type: journals
Link Between Alzheimer's and Heart FailureEmail this article to a colleague.
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New evidence supports a link between Alzheimer's disease and chronic heart failure, two of the ten leading causes of death in the United States. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - November 18, 2009 Category: Consumer Health News Source Type: news
New neuroimaging analysis technique identifies impact of Alzheimer's disease gene in healthy brainsEmail this article to a colleague.
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Brain imaging can offer a window into risk for diseases such as Alzheimer's disease. A new study has demonstrated that genetic risk is expressed in the brains of even those who are healthy, but carry some risk for AD. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 18, 2009 Category: Science Source Type: news
In AβPP-over expressing cultured human muscle fibers proteasome inhibition enhances phosphorylation of AβPP751 and GSK3β activation: effects mitigated by lithium and apparently relevant to sporadic inclusion-bodyEmail this article to a colleague.
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Muscle fiber degeneration in sporadic inclusion-body myositis (s-IBM) is characterized by accumulation of multiprotein aggregates, including aggregated amyloid-[beta] (A[beta])-precursor protein 751 (A[beta]PP751), A[beta], phosphorylated tau, and other 'Alzheimer-characteristic' proteins. Proteasome inhibition is an important component of the s-IBM pathogenesis. In brains of Alzheimer's disease (AD) patients and AD transgenic-mouse models, phosphorylation of neuronal A[beta]PP695 (p-A[beta]PP) on Thr668 (equivalent to T724 of A[beta]PP751) is considered detrimental because it increases generation of cytotoxic A[beta] and ...
Source: Journal of Neurochemistry - November 18, 2009 Category: Neurology Authors: Chiara Terracciano, Anna Nogalska, W. King Engel, Valerie Askanas Source Type: journals
Tau as a potential novel therapeutic target in ischemic strokeEmail this article to a colleague.
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Stroke is associated with high mortality and major disability burdens worldwide, but there are few effective and widely available therapies. Tau plays an important role in promoting microtubule assembly and stabilizing microtubule networks with phosphorylation regulating these functions. Based on the "ischemia-reperfusion theory" of Alzheimer's disease, some previous studies have focused on the relationship of tau and Alzheimer lesions in experimental brain ischemia. Thus, we hypothesize that the alterations in phosphorylation of tau are critical to microtubule dynamics and metabolism, and contribute to the pathophysiologi...
Source: Journal of Cellular Biochemistry - November 18, 2009 Category: Biochemistry Authors: Guo-Qing Zheng, Xiu-Min Wang, Yan Wang, Xiao-Tong Wang Source Type: journals
NHS Choices assessment: Quality of dementia care in hospitalsEmail this article to a colleague.
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Source: NHS Choices
Area: News
A report commissioned by the Alzheimer's Society has concluded that there is 'unacceptable variation in the quality of dementia care provided on general wards in hospitals across England, Wales and Northern Ireland'.
The report - 'Counting the Cost' - is based on the findings of a survey involving 1,291 carers, 657 nursing staff and 479 nurse/ward managers from general wards in hospitals across England, Wales and Northern Ireland. People who agreed to take part completed questionnaires on the quality of care given to people with dementia.
One of the main findings ...
Source: NeLM - Mental Health - November 18, 2009 Category: Psychiatry Source Type: organizations
Vaccines for AIDS, Alzheimer's, herpes on the horizonEmail this article to a colleague.
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Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it.
Many could be on the market in... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - November 18, 2009 Category: American Health Source Type: news
The choroid plexus response to a repeated peripheral inflammatory stimulusEmail this article to a colleague.
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Conclusions:
These observations contribute to a better understanding of the brain response to peripheral inflammation and pave the way to study their impact on the progression of several disorders of the central nervous system in which inflammation is known to be implicated. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - November 18, 2009 Category: Neuroscience Authors: Fernanda MarquesJoao SousaGiovanni CoppolaDaniel GeschwindNuno SousaJoana PalhaMargarida Correia-Neves Source Type: journals
Presenilin transgenic mice as models of Alzheimer's disease.Email this article to a colleague.
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Mutations in presenilin-1 (PS1) and presenilin-2 (PS2) cause familial Alzheimer's disease (FAD). Presenilins influence multiple molecular pathways and are best known for their role in the gamma-secretase cleavage of type I transmembrane proteins including the amyloid precursor protein (APP). PS1 and PS2 FAD mutant transgenic mice have been generated using a variety of promoters. PS1-associated FAD mutations have also been knocked into the endogenous mouse gene. PS FAD mutant mice consistently show elevations of Abeta42 with little if any effect on Abeta40. When crossed with plaque forming APP FAD mutant lines, the PS1 ...
Source: Brain Structure and Function - November 18, 2009 Category: Neuroscience Authors: Elder GA, Gama Sosa MA, De Gasperi R, Dickstein DL, Hof PR Tags: Brain Struct Funct Source Type: journals
CSF phospho-tau is independent of age, cognitive status and gender of neurological patientsEmail this article to a colleague.
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Abstract CSF phospho-tau (p-tau181) levels have shown good diagnostic utility in differential diagnosis of Alzheimer disease (AD). Unlike total-tau (t-tau),
age related changes of this promising biomarker are sparsely studied. The aim of the study was to determine whether p-tau181 is dependent on age, cognitive status or gender in patients with different neurological diseases who underwent diagnostic
lumbar puncture and who had no clinical evidence of neurodegenerative diseases. CSF levels of p-tau181 and total-tau (t-tau) of 46 neurologic patients (age range 22–89 years; 22 male, 24 female) were a...
Source: Journal of Neurology - November 17, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals
Clock Test Deficits Are Associated With Semantic Memory Impairment in Alzheimer DiseaseEmail this article to a colleague.
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Based on previous findings, we hypothesized that Clock Test deficits in patients with Alzheimer disease (AD) are associated primarily with the impairment of semantic memory regarding the appearance and functionality of a clock. To scrutinize this hypothesis, we developed a Clock Questionnaire that examined the semantic knowledge of the concept of a ‘‘Clock’’ and correlated scores from the questionnaire with performance in Clock Drawing, Clock Setting, and Clock Reading by healthy control participants and patients with mild cognitive impairment, early AD, and progressed AD. The Rey-Osterrieth-Complex...
Source: Journal of Geriatric Psychiatry and Neurology - November 17, 2009 Category: Genetics & Stem Cells Authors: Leyhe, T., Saur, R., Eschweiler, Gerhard. W., Milian, M. Tags: Articles Source Type: journals
